Shimizu Takatsune 清水孝恒

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SHIMIZU Takatsune 清水孝恒

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Researcher Number	40407101
Other IDs
Affiliation (Current)	2025: 星薬科大学, 薬学部, 准教授
Affiliation (based on the past Project Information) *help	2012 – 2024: 星薬科大学, 薬学部, 准教授 2011: 慶應義塾大学, 医学部, 特任助教 2008 – 2010: Keio University, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 50010:Tumor biology-related / Tumor biology / Tumor biology / Experimental pathology
Keywords	Principal Investigator 骨肉腫 / 転移巣 / 治療抵抗性 / 腫瘍免疫 / がん微小環境 / 癌微小環境 / 腫瘍 / 血管新生 / 代謝 / 転移 … More / autophagy / drug resistance / dormancy / osteosarcoma / 微小環境 / 環境 / 癌 Less

Elucidation of molecular mechanisms involved in the exhaustion of immune system in osteosarcomaPrincipal Investigator
- Principal Investigator
  
  清水孝恒
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Hoshi University
Elucidation of molecular mechanisms involved in the regulation of tumor immunity in osteosarcomaPrincipal Investigator
- Principal Investigator
  
  Shimizu Takatsune
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Hoshi University
Development of novel therapeutic approaches based on the elucidation of disease specific metabolism in osteosarcomaPrincipal Investigator
- Principal Investigator
  
  Shimizu Takatsune
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Hoshi University
Investigation of the molecular mechanisms underlying therapeutic resistance in osteosarcoma metastasisPrincipal Investigator
- Principal Investigator
  
  SHIMIZU TAKATSUNE
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor biology
- Research Institution
  Hoshi University
Investigation and conquest of the therapeutic resistant dormancy in osteosarcoma mediated by insulin-like growth factor (IGF) signalingPrincipal Investigator
- Principal Investigator
  
  SHIMIZU TAKATSUNE
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor biology
- Research Institution
  Hoshi University
Investigation of the roles of tumor environment in osteosarcomaPrincipal Investigator
- Principal Investigator
  
  SHIMIZU Takatsune
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor biology
- Research Institution
  Keio University
Establishment and analysis of mouse tumor models from multipotent bone marrow stromal cells overexpressing c-MYCPrincipal Investigator
- Principal Investigator
  
  SHIMIZU Takatsune
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Experimental pathology
- Research Institution
  Keio University

[Book] 統合分子薬理学vol.2 がんと緩和の分子レベル治療2022
- Author(s)
  成田年、加藤良規、清水孝恒、鳥越一宏
- Total Pages
  327
- Publisher
  京都廣川書店
- Data Source
  KAKENHI-PROJECT-21K07134
[Book] 分子病態薬理学Ⅲ2017
- Author(s)
  成田年、加藤良規、清水孝恒、鳥越一宏
- Total Pages
  326
- Publisher
  京都廣川書店
- ISBN
  9784909197160
- Data Source
  KAKENHI-PROJECT-15K06845
[Book] 実験医学増刊号　がん微小環境と標的治療2015
- Author(s)
  清水孝恒
- Total Pages
  207
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-24501320
[Book] モデル動物利用マニュアル　疾患モデルの作成と利用　がん2012
- Author(s)
  清水孝恒、佐谷秀行
- Total Pages
  633
- Publisher
  LIFE-SCIENCE INFORMATION CENTER
- Data Source
  KAKENHI-PROJECT-24501320
[Book] がん幹細胞研究の動向と治療標的としての将来性.最新医学(特集:がん幹細胞と支持細胞を標的とする薬剤の開発)2011
- Author(s)
  清水孝恒, 吉田剛, 佐谷秀行
- Data Source
  KAKENHI-PROJECT-22700887
[Book] 最新医学2011
- Author(s)
  清水孝恒、吉田剛、佐谷秀行
- Total Pages
  6
- Publisher
  最新医学社
- Data Source
  KAKENHI-PROJECT-22700887
[Journal Article] Single?agent nintedanib suppresses metastatic osteosarcoma growth by inhibiting tumor vascular formation2024
- Author(s)
  Shimizu Takatsune、Sagara Atsunobu、Fukuchi Yumi、Muto Akihiro
- Journal Title
  
  Oncology Letters
  
  Volume: 27 Issue: 3 Pages: 1-11
- DOI
  10.3892/ol.2024.14254
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07134, KAKENHI-PROJECT-22H04922
[Journal Article] Keratinocyte-Derived Cytokine in the Hippocampus Disrupts Extinction of Conditioned Fear Memory in Tumor-Bearing Mice2024
- Author(s)
  Ikeda Hiroko、Yamagishi Aimi、Yonemochi Naomi、Yamamoto Shogo、Shimizu Takatsune、Muto Akihiro、Waddington John L.、Kamei Junzo
- Journal Title
  
  Molecular Neurobiology
  
  Volume: in press Issue: 9 Pages: 6454-6468
- DOI
  10.1007/s12035-024-03992-1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K07134
[Journal Article] Cancer aggravation due to persistent pain signals with the increased expression of pain-related mediators in sensory neurons of tumor-bearing mice2023
- Author(s)
  Tanaka Kenichi、Kondo Takashige、Narita Michiko、Muta Takeru、Yoshida Sara、Sato Daisuke、Suda Yukari、Hamada Yusuke、Shimizu Takatsune、Kuzumaki Naoko、Narita Minoru
- Journal Title
  
  Molecular Brain
  
  Volume: 16 Issue: 1 Pages: 1-11
- DOI
  10.1186/s13041-023-01001-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07134
[Journal Article] Potential risk of driving performance under combined conditions of taking second-generation antihistamines and attending calls using a hands-free function2023
- Author(s)
  Sagara Atsunobu、Nagahama Akihito、Aki Hayato、Yoshimura Hiroki、Hiraide Makoto、Shimizu Takatsune、Sano Motohiko、Yumoto Tetsuro、Hosoe Tomoo、Tanaka Kenji
- Journal Title
  
  Traffic Injury Prevention
  
  Volume: 25 Issue: 1 Pages: 36-40
- DOI
  10.1080/15389588.2023.2265002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K07134
[Journal Article] Depletion of R270C Mutant p53 in Osteosarcoma Attenuates Cell Growth but Does Not Prevent Invasion and Metastasis In Vivo2022
- Author(s)
  Shimizu Takatsune、Sugihara Eiji、Takeshima Hideyuki、Nobusue Hiroyuki、Yamaguchi Rui、Yamaguchi-Iwai Sayaka、Fukuchi Yumi、Ushijima Toshikazu、Muto Akihiro、Saya Hideyuki
- Journal Title
  
  Cells
  
  Volume: 11 Issue: 22 Pages: 3614-3614
- DOI
  10.3390/cells11223614
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07131, KAKENHI-PROJECT-21K07134, KAKENHI-PROJECT-22K07179, KAKENHI-PROJECT-22H04922, KAKENHI-PROJECT-20H00518
[Journal Article] MEK inhibition preferentially suppresses anchorage‐independent growth in osteosarcoma cells and decreases tumors in vivo2021
- Author(s)
  Shimizu Takatsune、Kimura Kiyomi、Sugihara Eiji、Yamaguchi‐Iwai Sayaka、Nobusue Hiroyuki、Sampetrean Oltea、Otsuki Yuji、Fukuchi Yumi、Saitoh Kaori、Kato Keiko、Soga Tomoyoshi、Muto Akihiro、Saya Hideyuki
- Journal Title
  
  Journal of Orthopaedic Research
  
  Volume: - Issue: 12 Pages: 2732-2743
- DOI
  10.1002/jor.25023
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07243, KAKENHI-PROJECT-18K07247, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-20H00518, KAKENHI-PROJECT-21K07131
[Journal Article] The Inhibitor of Apoptosis Protein Livin Confers Resistance to Fas-Mediated Immune Cytotoxicity in Refractory Lymphoma2020
- Author(s)
  Sugihara Eiji、Hashimoto Norisato、Osuka Satoru、Shimizu Takatsune、Ueno Sayaka、Okazaki Shogo、Yaguchi Tomonori、Kawakami Yutaka、Kosaki Kenjiro、Sato Taka-Aki、Okamoto Shinichiro、Saya Hideyuki
- Journal Title
  
  Cancer Research
  
  Volume: 80 Issue: 20 Pages: 4439-4450
- DOI
  10.1158/0008-5472.can-19-3993
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K16315, KAKENHI-PROJECT-19K24054, KAKENHI-PROJECT-20H00518, KAKENHI-PROJECT-18K07224, KAKENHI-PROJECT-18K07247
[Journal Article] Rock inhibition suppresses osteosarcoma tumorigenesis by inducing terminal adipocyte differentiation in chemoresistant stemlike cells2019
- Author(s)
  1.Takahashi N, Nobusue H, Shimizu T, Sugihara E, Yamaguchi-Iwai S, Onishi N, Kunitomi H, Kuroda T, Saya H
- Journal Title
  
  Cancer Research
  
  Volume: in press Issue: 12 Pages: 3088-3099
- DOI
  10.1158/0008-5472.can-18-2693
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07247, KAKENHI-PROJECT-16J40108, KAKENHI-PROJECT-18K07224, KAKENHI-PROJECT-19K07696, KAKENHI-PROJECT-17H01401, KAKENHI-PROJECT-17H04355, KAKENHI-PROJECT-16H06276
[Journal Article] Activation of ventral tegmental area dopaminergic neurons reverses pathological allodynia resulting from nerve injury or bone cancer2018
- Author(s)
  Watanabe Moe、Narita Michiko、Hamada Yusuke、Yamashita Akira、Tamura Hideki、Ikegami Daigo、Kondo Takashige、Shinzato Tatsuto、Shimizu Takatsune、Fukuchi Yumi、Muto Akihiro、Okano Hideyuki、Yamanaka Akihiro、Tawfik Vivianne L、Kuzumaki Naoko、Navratilova Edita、Porreca Frank、Narita Minoru
- Journal Title
  
  Molecular Pain
  
  Volume: 14 Pages: 1-10
- DOI
  10.1177/1744806918756406
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K14936, KAKENHI-PROJECT-26293346, KAKENHI-PUBLICLY-16H01271, KAKENHI-PUBLICLY-17H05563, KAKENHI-PROJECT-15K06845, KAKENHI-PROJECT-18K07247
[Journal Article] Simvastatin-Induced Apoptosis in Osteosarcoma Cells: A Key Role of RhoA-AMPK/p38 MAPK Signaling in Antitumor Activity.2017
- Author(s)
  Kamel WA, Sugihara E, Nobusue H, Yamaguchi-Iwai S, Onishi N, Maki K, Fukuchi Y, Matsuo K, Muto A, Saya H, Shimizu T.
- Journal Title
  
  Molecular Cancer Therapeutics
  
  Volume: 16 Issue: 1 Pages: 182-192
- DOI
  10.1158/1535-7163.mct-16-0499
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16J40108, KAKENHI-PROJECT-15K06840, KAKENHI-PROJECT-15K06845, KAKENHI-PROJECT-16K07125
[Journal Article] ：Calcitriol exerts an anti-tumor effect in osteosarcoma by inducing the endoplasmic reticulum stress response.2017
- Author(s)
  Shimizu T, Kamel WA, Yamaguchi-Iwai S, Fukuchi Y, Muto A, Saya H.
- Journal Title
  
  Cancer Science
  
  Volume: 108 Issue: 9 Pages: 1793-1802
- DOI
  10.1111/cas.13304
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H01401, KAKENHI-PROJECT-16J40108, KAKENHI-PROJECT-15K06845
[Journal Article] Synergistic antiproliferative effect of imatinib and adriamycin in platelet-derived growth factor receptor-expressing osteosarcoma cells.2015
- Author(s)
  Yamaguchi SI, Ueki A, Sugihara E, Onishi N, Yaguchi T, Kawakami Y, Horiuchi K, Morioka H, Matsumoto M, Nakamura M, Muto A, Toyama Y, Saya H, Shimizu T.
- Journal Title
  
  Cancer Sci.
  
  Volume: 106 Issue: 7 Pages: 875-882
- DOI
  10.1111/cas.12686
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K06840, KAKENHI-PROJECT-15K06845, KAKENHI-PROJECT-15K20161, KAKENHI-PROJECT-26221005
[Journal Article] IGF2 Preserves Osteosarcoma Cell Survival by Creating an Autophagic State of Dormancy That Protects Cells against Chemotherapeutic Stress2014
- Author(s)
  Shimizu T, Sugihara E, Yamaguchi-Iwai S, Tamaki S, Koyama Y, Kamel W, Ueki A, Ishikawa T, Chiyoda T, Osuka S, Onishi N, Ikeda H, Kamei J, Matsuo K, Fukuchi Y, Nagai T, Toguchida J, Toyama Y, Muto A, Saya H
- Journal Title
  
  Cancer Res
  
  Volume: 74 Issue: 22 Pages: 6531-6541
- DOI
  10.1158/0008-5472.can-14-0914
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-13J06657, KAKENHI-ORGANIZER-22130001, KAKENHI-PLANNED-22130007, KAKENHI-PROJECT-24390353, KAKENHI-PROJECT-24501320, KAKENHI-PROJECT-25830088, KAKENHI-PROJECT-25860245, KAKENHI-PROJECT-26830082
[Journal Article] Regulation of MKL1 via actin cytoskeleton dynamics drives adipocyte differentiation.2014
- Author(s)
  Nobusue H
- Journal Title
  
  Nat Commun
  
  Volume: 5 Issue: 1 Pages: 3368-3368
- DOI
  10.1038/ncomms4368
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-22130001, KAKENHI-PLANNED-22130002, KAKENHI-PLANNED-22130007, KAKENHI-PROJECT-24501320, KAKENHI-PROJECT-25253069, KAKENHI-PROJECT-25830088, KAKENHI-PROJECT-25860245
[Journal Article] Glycan profiling of gestational choriocarcinoma using a lectin microarray2014
- Author(s)
  Kobayashi Y, Masuda K, Banno K, Kobayashi N, Umene K, Nogami Y, Tsuji K, Ueki A, Nomura H, Sato K, Tominaga E, Shimizu T, Saya H, Aoki D
- Journal Title
  
  Oncology Reports
  
  Volume: 31 Issue: 3 Pages: 1121-1131
- DOI
  10.3892/or.2014.2979
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24501320, KAKENHI-PROJECT-24592530
[Journal Article] IGF1 receptor signaling regulates adaptive radioprotection in glioma stemcells2013
- Author(s)
  Osuka S. Sampetrean O, Shimizu T, Saga l, Onishi N, Sugihara E, Okubo J, Fujita S, Takano S, Matsumura A, Saya H
- Journal Title
  
  Stem Cells
  
  Volume: 31 Issue: 4 Pages: 627-640
- DOI
  10.1002/stem.1328
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J00382, KAKENHI-PROJECT-13J06657, KAKENHI-PROJECT-22249055, KAKENHI-PROJECT-23790376, KAKENHI-PROJECT-24501320, KAKENHI-PROJECT-24659645, KAKENHI-PROJECT-25830088, KAKENHI-PROJECT-25860245
[Journal Article] TNFα promotes osteosarcoma progression by maintaining tumor cells in an undifferentiated state.2013
- Author(s)
  Mori T
- Journal Title
  
  Oncogene
  
  Volume: Epub ahead of print Issue: 33 Pages: 4236-4241
- DOI
  10.1038/onc.2013.545
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-22130001, KAKENHI-PLANNED-22130007, KAKENHI-PROJECT-24390359, KAKENHI-PROJECT-24501320, KAKENHI-PROJECT-24592244, KAKENHI-PROJECT-25861341
[Journal Article] Twist2 functions as a tumor suppressor in murine osteosarcoma cells.2013
- Author(s)
  Ishikawa T, Shimizu T, Ueki A, Yamaguchi S, Onishi N, Sugihara E, Kuninaka S, Miyamoto T, Morioka H, Nakayama R, Kobayashi E, Toyama Y, Mabuchi Y, Matsuzaki Y, Yamaguchi R, Miyano S and Saya H
- Journal Title
  
  Cancer Sci
  
  Volume: (in press) Issue: 7 Pages: 880-888
- DOI
  10.1111/cas.12163
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790376, KAKENHI-PROJECT-24390359, KAKENHI-PROJECT-24501320, KAKENHI-PROJECT-24590360, KAKENHI-PROJECT-24592244, KAKENHI-PROJECT-24659789, KAKENHI-PROJECT-25830088, KAKENHI-PROJECT-25860245
[Journal Article] LATS1/WARTS phosphorylates MYPT1 to counteract PLK1 and regulate mammalian mitotic progression2012
- Author(s)
  Chiyoda, T.
- Journal Title
  
  J Cell Biol
  
  Volume: 197 Issue: 5 Pages: 625-41
- DOI
  10.1083/jcb.201110110
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20227006, KAKENHI-PROJECT-24241062, KAKENHI-PROJECT-24501320, KAKENHI-PROJECT-24590360, KAKENHI-PROJECT-24659017, KAKENHI-PUBLICLY-23134507, KAKENHI-PUBLICLY-24116513
[Journal Article] Fibroblast growth factor-2 (Fgf2) is an important factor that maintains cellular immaturity and contributes to aggressiveness of osteosarcoma2012
- Author(s)
  Shimizu T, et al
- Journal Title
  
  Molecular Cancer Research
  
  Volume: 10 Pages: 454-468
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22700887
[Journal Article] Fibroblast growth factor-2 is an important factor that maintains cellular immaturity and contributes to aggressiveness of osteosarcoma2012
- Author(s)
  Shimizu T, Ishikawa T, Iwai S, Ueki A, Sugihara E, Onishi N, Kuninaka S, Miyamoto T, Toyama Y, Ijiri H, Mori H, Matsuzaki Y, Yaguchi T, Nishio H, Kawakami Y, Ikeda Y, Saya H
- Journal Title
  
  Mol. Cancer Res.
  
  Volume: 10 Pages: 454-468
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22700887
[Journal Article] Up-regulation of imp3 confers in vivo tumorigenicity on murine osteosarcoma cells.2012
- Author(s)
  Ueki A, Shimizu T, Masuda K, Yamaguchi SI, Ishikawa T, Sugihara E, Onishi N, Kuninaka S, Miyoshi K, Muto A, Toyama Y, Banno K, Aoki D, Saya H.
- Journal Title
  
  PLoS One
  
  Volume: 7(11) Issue: 11 Pages: e50621-e50621
- DOI
  10.1371/journal.pone.0050621
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790376, KAKENHI-PROJECT-24501320, KAKENHI-PLANNED-22130007
[Journal Article] Establishment of a choriocarcinoma model from immortalized normal extravillous trophoblast cells transduced with HRASV122011
- Author(s)
  Kobayashi Y, Shimizu T, Naoe H, Ueki A, Ishizawa J, Chiyoda T, Onishi N, Sugihara E, Nagano O, Banno K, Kuninaka S, Aoki D, Saya H
- Journal Title
  
  Am. J. Pathol
  
  Volume: 179 Pages: 1471-82
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22700887
[Journal Article] Ink4a and Arf are crucial factors in the determination of the cell of origin and the therapeutic sensitivity of Myc-induced mouse lymphoid tumor2011
- Author(s)
  Sugihara E, Shimizu T, et al
- Journal Title
  
  Oncogene
  
  Volume: (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22700887
[Journal Article] Establishment of a choriocarcinoma model from immortalized normal extravillous trophoblast cells transduced with HRASV122011
- Author(s)
  Kobayashi Y, Shimizu T, et al
- Journal Title
  
  American Journal of Pathology
  
  Volume: 179 Pages: 1471-1482
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22700887
[Journal Article] c-MYC overexpression with loss of Ink4a/Arf transforms bone marrow stromal cells into osteosarcoma accompanied by loss of adipogenesis2010
- Author(s)
  Takatsune Shimizu, et al.
- Journal Title
  
  Oncogene
  
  Volume: 29 Pages: 5687-5699
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22700887
[Journal Article] c-MYC overexpression with loss of Ink4a/Arf transforms bone marrow stromal cells into osteosarcoma accompanied by loss of adipogenesis2010
- Author(s)
  Shimizu T, Ishikawa T, Sugihara E, Kuninaka S, Miyamoto T, Mabuchi Y, Matsuzaki Y, Tsunoda T, Miya F, Morioka H, Nakayama R, Kobayashi E, Toyama Y, Kawai A, Ichikawa H, Hasegawa T, Okada S, Ito T, Ikeda Y, Suda T, Saya H
- Journal Title
  
  Oncogene
  
  Volume: 29 Pages: 5687-99
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22700887
[Journal Article] M-Csf inhibition selectively targets pathological angiogenesis and lymphangiogenesis2009
- Author(s)
  Kubota Y, Takubo K, Shimizu T, Ohno H, Kishi K, Shibuya M, Saya H, Suda T.
- Journal Title
  
  J. Exp. Med. 206
  
  Pages: 1089-1102
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790310
[Patent] 骨腫瘍の治療剤及び骨腫瘍等の治療のためのチャネル薬の評価方法2020
- Inventor(s)
  今泉祐治、清水孝恒、佐谷秀行、他総7名
- Industrial Property Rights Holder
  今泉祐治、清水孝恒、佐谷秀行、他総7名
- Industrial Property Rights Type
  特許
- Filing Date
  2020
- Data Source
  KAKENHI-PROJECT-18K07247
[Presentation] 線維化抑制薬ニンテダニブは骨肉腫の生体内進展を抑制する2024
- Author(s)
  清水孝恒、市川紗衣、市川穂菜美、福地由美、武藤章弘
- Organizer
  日本薬学会第１４４年会
- Data Source
  KAKENHI-PROJECT-21K07134
[Presentation] 転写調節因子MKL1は間質細胞からがん関連線維芽細胞への転換を制御する2023
- Author(s)
  上瀧萌、國富晴子、清水孝恒、サンペトラオルテア、植野さやか、佐谷秀行、信末博行
- Organizer
  第８２回日本癌学会学術総会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07134
[Presentation] ROCK阻害薬ファスジルは治療抵抗性骨肉腫細胞において化学療法による抗腫瘍効果を高める2023
- Author(s)
  信末博行、清水孝恒、上瀧萌、住吉清香、近藤由佳、山田勢至、塚本徹哉、佐谷秀行
- Organizer
  第８２回日本癌学会学術総会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07134
[Presentation] ニンテダニブは骨肉腫の原発巣と転移巣の形成を抑制する2023
- Author(s)
  清水孝恒、市川紗衣、市川穂菜美、唐鎌理子、高橋佑果、滝澤史織、飛田朱里、武藤章弘
- Organizer
  第８２回日本癌学会学術総会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07134
[Presentation] R270C型のp53変異体は転写活性を失うも、骨肉腫の生体内進展には寄与しない2022
- Author(s)
  清水孝恒、杉原英志、信末博行、山口さやか、武藤章弘、佐谷秀行
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K07134
[Presentation] 骨肉腫悪性化の分子基盤探索と薬物治療開発2022
- Author(s)
  清水孝恒
- Organizer
  ２０２１年度　先端モデル動物支援プラットフォーム成果発表会
- Invited
- Data Source
  KAKENHI-PROJECT-21K07134
[Presentation] Investigation of therapeutic potential of MEK inhibition in osteosarcoma2021
- Author(s)
  木村聖美, 杉原英志, 山口さやか, 信末博行, サンペトラオルテア, 大槻雄二, 武藤章弘, 佐谷秀行, 清水孝恒
- Organizer
  第８０回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K07134
[Presentation] 骨肉腫腫瘍免疫の解析、新規免疫療法開発のための解析モデル基盤形成2021
- Author(s)
  清水孝恒、木村聖美、杉原英志、信末博行、武藤章弘、佐谷秀行
- Organizer
  第８０回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K07134
[Presentation] 骨肉腫に対するMEK阻害療法の検証2021
- Author(s)
  清水孝恒、木村聖美、武藤章弘、佐谷秀行
- Organizer
  第53回　日本臨床分子形態学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-21K07134
[Presentation] Trametinib preferentially suppresses anchorage-independent growth in osteosarcoma cells and exerts anti-tumor activity2020
- Author(s)
  清水孝恒、木村聖美、杉原英治、山口さやか、信末博行、武藤章弘、佐谷秀行
- Organizer
  第７９回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K07247
[Presentation] MEK阻害薬trametinibは骨肉腫細胞にapoptosisを誘導し抗腫瘍効果を示す2020
- Author(s)
  清水孝恒、木村聖美、武藤章弘、佐谷秀行
- Organizer
  第52回日本臨床分子形態学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-18K07247
[Presentation] Benzaldehydeは腫瘍細胞における14-3-3ζの高発現を介してAMPK活性を亢進させる。2019
- Author(s)
  齋藤潤、大西伸幸、杉原英志、清水孝恒、木村聖美、小池直義、サンペトラ　オルテア、岡崎章悟、信末博行、笠間隆志、佐谷秀行
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K07247
[Presentation] 骨肉腫難治例の治療抵抗性分子機構の解明と新規治療法開発にむけた基礎的検討2019
- Author(s)
  清水孝恒、武藤章弘、佐谷秀行
- Organizer
  第13回日本緩和医療薬学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-18K07247
[Presentation] 骨肉腫のインスリンシグナルによる形態変化と治療抵抗性獲得2018
- Author(s)
  清水孝恒，武藤章弘，佐谷秀行
- Organizer
  第50回日本臨床分子形態学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-18K07247
[Presentation] サバイビン阻害薬は小胞体ストレスを誘導し、骨肉腫に対しin vitro，in vivoで抗腫瘍効果を示す2018
- Author(s)
  木村聖美，杉原英志，信末博行，山口さやか，武藤章弘，佐谷秀行，清水孝恒
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K07247
[Presentation] LivinはFas発現回復によるリンパ腫抑制バリアに対する抵抗性を付与する2017
- Author(s)
  杉原英志、橋本典諭、大須賀覚、植野さやか、清水孝恒、佐谷秀行
- Organizer
  第76回　日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-15K06845
[Presentation] マウス骨肉腫幹細胞と疾患克服への挑戦2017
- Author(s)
  清水孝恒
- Organizer
  日本薬学会東海支部特別講演会
- Place of Presentation
  名古屋
- Invited
- Data Source
  KAKENHI-PROJECT-15K06845
[Presentation] カルシトリオールは小胞体ストレス反応を誘導することにより骨肉腫に抗腫瘍効果を示す2017
- Author(s)
  清水孝恒、山口さやか、武藤章弘、佐谷秀行
- Organizer
  第76回　日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-15K06845
[Presentation] Novel therapeutic approach with statins for lethal osteosarcoma2016
- Author(s)
  槇健太、清水孝恒、福地由美、武藤章弘
- Organizer
  第89回日本薬理学会年会
- Place of Presentation
  横浜
- Year and Date
  2016-03-09
- Data Source
  KAKENHI-PROJECT-15K06845
[Presentation] スタチン系薬剤はメバロン酸合成経路を阻害し、AMPK、p38MAPKの活性化を介して骨肉腫に抗腫瘍効果を発揮する2016
- Author(s)
  カメル・ワリード、杉原英志、山口さやか、信末博行、大西伸幸、武藤章弘、佐谷秀行、清水孝恒
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-15K06845
[Presentation] Statins induce apoptosis in osteosarcoma cells by activation of Ampk and p38 via suppression of mevalonate pathway2016
- Author(s)
  Kamel AW, Sugihara E, Yamaguchi S, Nobusue H, Maki K, Muto A, Saya H, Shimizu T
- Organizer
  American Association for Cancer Research Annual Meeting 2016
- Place of Presentation
  New Orleans, USA
- Year and Date
  2016-04-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06845
[Presentation] イマチニブとアドリアマイシンの併用は、PDGFR を発現する骨肉腫に対し、相乗的な抗腫瘍効果を呈する2015
- Author(s)
  山口さやか、杉原英志、大西伸幸、菊田一貴、堀内圭輔、森岡秀夫、佐谷秀行、清水孝恒
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-15K06845
[Presentation] ROCK 阻害剤は骨肉腫幹細胞の脂肪細胞への終末分化を誘導する2015
- Author(s)
  高橋信博、信末博行、清水孝恒、大西伸幸、杉原英志、佐谷秀行
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-15K06845
[Presentation] 新規B 細胞リンパ腫モデルを用いたリンパ腫発症及び維持におけるFas の抑制制御2015
- Author(s)
  杉原英志、橋本典諭、植野さやか、清水孝恒、佐谷秀行
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-15K06845
[Presentation] アクチン細胞骨格動態に基づく脂肪分化制御による骨肉腫幹細胞の治療戦略2015
- Author(s)
  信末博行、大西伸幸、清水孝恒、杉原英志、沖嘉尚、千代田達幸、高橋信博、赤司浩一、加野浩一郎、佐谷秀行
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-15K06845
[Presentation] インスリンシグナルによる骨肉腫休眠状態は微小残存病変につながる2013
- Author(s)
  清水孝恒、石川智樹、山口さやか、杉原英志、植木有紗、大西伸幸、國仲慎治、武藤章弘、安積彩香、大久保智啓、佐谷秀行
- Organizer
  第７２回日本癌学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24501320
[Presentation] Characterization and conquest of mouse osteosarcoma stem cells2013
- Author(s)
  Takatsune Shimizu, Akihiro Muto, Hideyuki Saya
- Organizer
  第３６回日本分子生物学会年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-24501320
[Presentation] Multifunctional roles of Fibroblast growth factor-2(Fgf2) in the histopathology of murine osteosarcoma2011
- Author(s)
  清水孝恒
- Organizer
  第70回日本癌学会学術集会
- Place of Presentation
  名古屋
- Year and Date
  2011-10-04
- Data Source
  KAKENHI-PROJECT-22700887
[Presentation] Multifunctional roles of Fibroblast growth factor-2 (Fgf2) in the histopat hology of murine osteosarcoma2011
- Author(s)
  清水孝恒
- Organizer
  第70回日本癌学会学術集会
- Place of Presentation
  名古屋国際会議場(愛知県)
- Year and Date
  2011-10-04
- Data Source
  KAKENHI-PROJECT-22700887
[Presentation] Mesenchymal differentiation potentials modified osteosarcoma stem cell activities2010
- Author(s)
  清水孝恒
- Organizer
  第101回アメリカ癌学会
- Place of Presentation
  Walter E.ワシントンコンベンションセンター
- Year and Date
  2010-04-22
- Data Source
  KAKENHI-PROJECT-22700887
[Presentation] Mesenchymal differentiation potentials modify osteosarcoma stem cell activities2010
- Author(s)
  清水孝恒
- Organizer
  American Association for cancer research 101^<st> Annual meeting 2010
- Place of Presentation
  Washington, U. S. A.
- Year and Date
  2010-04-21
- Data Source
  KAKENHI-PROJECT-22700887
[Presentation] Mesenchymal differentiation potentials modify osteosarcoma stem cell activities2010
- Author(s)
  清水孝恒
- Organizer
  101th Annual Meeting of American Association of Cancer Research
- Place of Presentation
  Washington
- Year and Date
  2010-04-21
- Data Source
  KAKENHI-PROJECT-20790310
[Presentation] Establishment and application of mouse osteosarcoma stem cells2009
- Author(s)
  清水孝恒
- Organizer
  第68回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2009-10-02
- Data Source
  KAKENHI-PROJECT-20790310
[Presentation] Establishment of osteosarcoma stem cell from bone marrow stromal cells2008
- Author(s)
  清水孝恒
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2008-10-28
- Data Source
  KAKENHI-PROJECT-20790310
[Presentation] Establisment of osteosarcoma stem cell from bone marrow stromal cells2008
- Author(s)
  清水孝恒
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2008-10-28
- Data Source
  KAKENHI-PROJECT-20790310
[Presentation] インスリン様増殖因子シグナルは骨肉腫細胞に治療抵抗性休眠状態を誘導する
- Author(s)
  清水孝恒
- Organizer
  第2回がんと代謝研究会
- Place of Presentation
  東京
- Year and Date
  2014-07-10 – 2014-07-11
- Invited
- Data Source
  KAKENHI-PROJECT-24501320
[Presentation] Molecular mechanism of in vivo tumorigenesis
- Author(s)
  Takatsune Shimizu
- Organizer
  The 11th Korea-Japan-Germany Joint Symposium on Cancer and Aging
- Place of Presentation
  Gyeongju, Korea
- Data Source
  KAKENHI-PROJECT-24501320
[Presentation] マウス骨肉腫幹細胞の樹立とその特徴
- Author(s)
  清水孝恒、佐谷秀行
- Organizer
  第１０回日本臨床腫瘍学会学術集会
- Place of Presentation
  大阪
- Invited
- Data Source
  KAKENHI-PROJECT-24501320
[Presentation] マウス骨肉腫幹細胞の同定と克服への挑戦
- Author(s)
  清水孝恒、武藤章弘、佐谷秀行
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Invited
- Data Source
  KAKENHI-PROJECT-24501320

1. SAYA Hideyuki

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
2. SOGA Tomoyoshi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. Yamanaka Akihiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 杉原英志

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
5. 信末博行

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
6. 岡崎章悟

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 森正樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 山下哲

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Shimizu Takatsune 清水 孝恒

SHIMIZU Takatsune 清水 孝恒

Research Projects

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Co-Researchers

Elucidation of molecular mechanisms involved in the exhaustion of immune system in osteosarcomaPrincipal Investigator

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Elucidation of molecular mechanisms involved in the regulation of tumor immunity in osteosarcomaPrincipal Investigator

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Development of novel therapeutic approaches based on the elucidation of disease specific metabolism in osteosarcomaPrincipal Investigator

Principal Investigator

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Investigation of the molecular mechanisms underlying therapeutic resistance in osteosarcoma metastasisPrincipal Investigator

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Investigation and conquest of the therapeutic resistant dormancy in osteosarcoma mediated by insulin-like growth factor (IGF) signalingPrincipal Investigator

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Investigation of the roles of tumor environment in osteosarcomaPrincipal Investigator

Principal Investigator

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Establishment and analysis of mouse tumor models from multipotent bone marrow stromal cells overexpressing c-MYCPrincipal Investigator

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[Book] 統合分子薬理学vol.2 がんと緩和の分子レベル治療2022

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[Book] 分子病態薬理学Ⅲ2017

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[Book] 実験医学増刊号 がん微小環境と標的治療2015

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[Book] モデル動物利用マニュアル 疾患モデルの作成と利用 がん2012

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[Book] がん幹細胞研究の動向と治療標的としての将来性.最新医学(特集:がん幹細胞と支持細胞を標的とする薬剤の開発)2011

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[Book] 最新医学2011

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[Journal Article] Single?agent nintedanib suppresses metastatic osteosarcoma growth by inhibiting tumor vascular formation2024

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DOI

Shimizu Takatsune 清水孝恒

SHIMIZU Takatsune 清水孝恒

[Book] 実験医学増刊号　がん微小環境と標的治療2015

[Book] モデル動物利用マニュアル　疾患モデルの作成と利用　がん2012