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Okazawa Makoto  岡澤 慎

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… Alternative Names

Makoto Okazawa  岡澤 慎

岡澤 慎  オカザワ マコト

OKAZAWA Makoto  岡澤 慎

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Researcher Number 40414130
Affiliation (Current) 2025: 国立研究開発法人国立循環器病研究センター, 研究所, 室長
Affiliation (based on the past Project Information) *help 2022 – 2023: 国立研究開発法人国立循環器病研究センター, 研究所, 室長
2019 – 2020: 国立研究開発法人国立循環器病研究センター, 研究所, 室長
2017: 国立研究開発法人国立循環器病研究センター, 研究所, 室長
2014: (公財)大阪バイオサイエンス研究所, システムズ生物学部門, 研究員
2013 – 2014: 独立行政法人国立循環器病研究センター, 研究所, 室長 … More
2012: 公益財団法人大阪バイオサイエンス研究所, その他部局等, 研究員
2011 – 2012: 公益財団法人大阪バイオサイエンス研究所, システムズ生物学部門, 研究員
2011: 財団法人 大阪バイオサイエンス研究所, システムズ生物学部門, 研究員
2011: 財団法人大阪バイオサイエンス研究所, システムズ生物学部門, 研究員
2009 – 2010: Osaka Bioscience Institute, システムズ生物学部門, 研究員
2009: 財団法人大阪バイオサイエンス研究所, システムズ生物学部門, 研究員
2008: システムズ, 生物学部門, 研究員
2007: Osaka Bioscience Institute, システムズ生物学部門, 研究員
2005 – 2006: (財)大阪バイオサイエンス研究所, システムズ生物学部門, 研究員 Less
Review Section/Research Field
Principal Investigator
General medical chemistry / Basic Section 53020:Cardiology-related / Cardiovascular medicine / Biological Sciences
Except Principal Investigator
Basic Section 53020:Cardiology-related / Neuroscience in general / Biological Sciences
Keywords
Principal Investigator
静止膜電位 / 小脳顆粒細胞 / 肺動脈性肺高血圧症 / 肺高血圧症 / カルシウムシグナル / 遺伝子発現 / 膜電位 / 転写因子 / 神経成熟 / シグナル伝達 … More / パッチクランプ法 / 神経発達 / 炎症 / インターロイキンー6 / 芳香族炭化水素受容体 / 芳香族環状炭化水素受容体 / 組織特異的遺伝子欠損マウス / アリルハイドロカーボン受容体 / 免疫学 / 循環器・高血圧 / TrkB / カルシウム / 神経分化 … More
Except Principal Investigator
神経回路 / 運動記憶 / 小脳 / 分子メカニズム / 環境要因 / 芳香族炭化水素受容体 / 転写因子 / 肺動脈性肺高血圧症 / マスター転写因子 / 蛋白燐酸化 / 運動制御 / マスター転写遺伝子 / 細胞内シグナル / 神経成熟 / 運動 / 記憶 / 神経ネットワーク / 基底核 / 神経伝達 / 発達 / 薬物依存 / 報酬・忌避記憶 / 大脳基底核 Less
  • Research Projects

    (10 results)
  • Research Products

    (35 results)
  • Co-Researchers

    (9 People)
  •  肺動脈性肺高血圧症における芳香族炭化水素受容体とIL-6シグナルのクロストークの解明Principal Investigator

    • Principal Investigator
      岡澤 慎
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53020:Cardiology-related
    • Research Institution
      National Cardiovascular Center Research Institute
  •  芳香族炭化水素受容体の発現・活性化に着目した肺動脈性肺高血圧症の病態形成機序解明

    • Principal Investigator
      水島 沙織
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53020:Cardiology-related
    • Research Institution
      National Cardiovascular Center Research Institute
  •  Investigation of the pathogenesis of pulmonary arterial hypertension using tissue-specific Ahr knockout micePrincipal Investigator

    • Principal Investigator
      Okazawa Makoto
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53020:Cardiology-related
    • Research Institution
      National Cardiovascular Center Research Institute
  •  Investigation of the pathogenesis of pulmonary hypertension through inflammatory signaling by TrkB in bronchial epithelial cellsPrincipal Investigator

    • Principal Investigator
      Makoto Okazawa
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Cardiovascular medicine
    • Research Institution
      National Cardiovascular Center Research Institute
  •  膜電位分極化による細胞分化の制御機構の研究Principal Investigator

    • Principal Investigator
      岡澤 慎
    • Project Period (FY)
      2013 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      National Cardiovascular Center Research Institute
  •  Activity-dependent calcium signaling plays a role in development and maturation of cerebellar granule cellsPrincipal Investigator

    • Principal Investigator
      OKAZAWA Makoto
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      General medical chemistry
    • Research Institution
      National Cardiovascular Center Research Institute
      Osaka Bioscience Institute
  •  Molecular studies of motor learning and maturation of the cerebellar network

    • Principal Investigator
      NAKANISHI Shigetada
    • Project Period (FY)
      2010 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (S)
    • Research Field
      Neuroscience in general
    • Research Institution
      Osaka Bioscience Institute
  •  Molecular mechanisms of neuronal development and maturation regulated by alteration of membrane potential using cerebellar granule cellsPrincipal Investigator

    • Principal Investigator
      OKAZAWA Makoto
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      General medical chemistry
    • Research Institution
      公益財団法人大阪バイオサイエンス研究所
      Osaka Bioscience Institute
  •  生後発達期における小脳顆粒細胞の電気的性質変化が神経回路形成に果たす役割Principal Investigator

    • Principal Investigator
      岡澤 慎
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      General medical chemistry
    • Research Institution
      Osaka Bioscience Institute
  •  Studies on molecular mechanisms that control development and function of the neural network

    • Principal Investigator
      NAKANISHI Shigetada
    • Project Period (FY)
      2005 – 2009
    • Research Category
      Grant-in-Aid for Specially Promoted Research
    • Review Section
      Biological Sciences
    • Research Institution
      Osaka Bioscience Institute

All 2012 2011 2010 2009 2008 2006 Other

All Journal Article Presentation

  • [Journal Article] Gene regulation via excitation and BDNF is mediated by induction and phosphorylation of the Etv1 transcription factor in cerebellar granule cells2012

    • Author(s)
      Abe, H., Okazawa, M. & Nakanishi, S.
    • Journal Title

      Proc.Natl.Acad.Sci.USA

      Volume: 109 Issue: 22 Pages: 8734-8739

    • DOI

      10.1073/pnas.1206418109

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22220005, KAKENHI-PROJECT-24790300, KAKENHI-PLANNED-23120011
  • [Journal Article] Gene regulation via excitation and BDNF is mediated by induction and phosphorylation of Etv1 nuclear factor in cerebellar granule cells2012

    • Author(s)
      Abe, H., Okazawa, M., Nakanishi, S.
    • Journal Title

      Proc.Natl.Acad.Sci.USA

      Pages: 8734-8739

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22220005
  • [Journal Article] The Etv1/Er81 transcription factor orchestrates activity-dependent gene regulation in the terminal maturation program of cerebellar granule cells2011

    • Author(s)
      H.Abe, M.Okazawa, S.Nakanishi
    • Journal Title

      PNAS

      Volume: 108 Pages: 12-497

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790294
  • [Journal Article] The Etv1/Er81 transcription factor orchestrates activity-dependent gene regulation in the terminal maturation program of cerebellar granule cells2011

    • Author(s)
      Abe, H., Okazawa, M., Nakanishi, S.
    • Journal Title

      Proc.Natl.Acad.Sci.USA

      Volume: 108 Issue: 30 Pages: 12497-12502

    • DOI

      10.1073/pnas.1109940108

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22220005, KAKENHI-PLANNED-23120011
  • [Journal Article] The Etv1/Er81 transcription factor orchestrates activity-dependent gene regulation in the terminal maturation program of cerebellar granule cells2011

    • Author(s)
      Abe H, Okazawa M, Nakanishi S
    • Journal Title

      Proc Natl Acad Sci USA

      Volume: 108 Pages: 12497-12502

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790294
  • [Journal Article] Protein kinase G dynamically modulates TASK1-mediated leak K+currents in cholinergic neurons of the basal forebrain2010

    • Author(s)
      Toyoda H, Saito M, Okazawa M, Hirao K, Sato H, Abe H, Takada K, Funabiki K, Takada M, Kaneko T, Kang Y
    • Journal Title

      J Neurosci

      Volume: 30 Pages: 5677-5689

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790294
  • [Journal Article] Protein Kinase G Dynamically Modulates TASK1-Mediated Leak K^+ Currents in Cholinergic Neurons of the Basal Forebrain2010

    • Author(s)
      Hiroki Toyoda, Mitsuru Saito, Makoto Okazawa et.al.
    • Journal Title

      Journal of Neuroscience Vol 30

      Pages: 5677-5689

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790294
  • [Journal Article] Protein Kinase G Dynamically Modulates TASK1-Mediated Leak K^+ Currents in Cholinergic Neurons of the Basal Forebrain2010

    • Author(s)
      H.Toyoda, M.Saito, M.Okazawa, K.Hirano, H.Sato, H.Abe, K.Takada, K.Funabiki, M.Takada, T.Kaneko, Y.Kang
    • Journal Title

      J.Neurosci.

      Volume: 30 Pages: 5677-5689

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790294
  • [Journal Article] Role of calcineur in signaling in membrane potential-regulated maturation of cerebellar granule cells2009

    • Author(s)
      Okazawa, M., et al.
    • Journal Title

      J. Neurosci 29

      Pages: 2938-2947

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17002016
  • [Journal Article] Abnormal Behavior in a Chromosome- Engineered Mouse Model for Human 15q11-13 Duplication Seen in Autism2009

    • Author(s)
      Jin Nakatani, …, Makoto Okazawa et.al.
    • Journal Title

      Cell Vol 137

      Pages: 1235-1246

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790294
  • [Journal Article] Abnormal behavior in a chromosome-engineered mouse model for human 15q11-13 duplication seen in autism2009

    • Author(s)
      Nakatani J, Tamada K, Hatanaka F, Ise S, Ohta H, Inoue K, Tomonaga S, Watanabe Y, Chung YJ, Banerjee R, Iwamoto K, Kato T, Okazawa M, Yamauchi K, Tanda K, Takao K, Miyakawa T, Bradley A, Takumi T
    • Journal Title

      Cell

      Volume: 137 Pages: 1235-1246

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790294
  • [Journal Article] Role of calcineurin signaling in membrane potential-regulated maturation of cerebellar granule cells2009

    • Author(s)
      Okazawa, M., Abe, H., Katsukawa, M., Iijima, K., Kiwada, T., Nakanishi, S.
    • Journal Title

      J. Neurosci. 29

      Pages: 2938-2947

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17002016
  • [Journal Article] Role of calcineurin signaling in membrane potential-regulated Maturation of cerebellar granule cells2009

    • Author(s)
      Okazawa, M.et al.
    • Journal Title

      J.Neurosci. 29

      Pages: 2939-2947

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17002016
  • [Journal Article] Dual regulation of NR2B and NR2C expression by NMDA receptor activation in mouse cerebellar granule cell cultures2008

    • Author(s)
      Iijima, K., Abe, H., Okazawa, M., Moriyoshi, K., Nakanishi, S.
    • Journal Title

      Proc. Natl. Acad. Sci. U.S.A. 105

      Pages: 12010-12015

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17002016
  • [Journal Article] Membrane potential-regulated Ca^<2+> signaling in development and maturation of cerebellar granule cells2006

    • Author(s)
      Nakanishi, S, Okazawa, M.
    • Journal Title

      Journal of Physiology 575

      Pages: 389-395

    • Data Source
      KAKENHI-PROJECT-17002016
  • [Journal Article] Membrane potential-regulated Ca^<2+> signaling in developmental and maturation of mammalian cerebellar granule cells2006

    • Author(s)
      Nakanishi S., Okazawa M.
    • Journal Title

      Journal of Physiology 575・2

      Pages: 389-395

    • Data Source
      KAKENHI-PROJECT-18790209
  • [Journal Article] Membrane potential-regulated Ca2+ signaling in development and maturation of cerebellar granule cells2006

    • Author(s)
      Nakanishi, S., Okazawa, M.
    • Journal Title

      J. Physiol. 575

      Pages: 389-395

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17002016
  • [Presentation] The Etv1/Er81 transcription factor regulates activity-dependent gene expression in the terminal maturation program of cerebellar granule cells2011

    • Author(s)
      H.Abe, M.Okazawa, S.Nakanishi
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2011-12-13
    • Data Source
      KAKENHI-PROJECT-21790294
  • [Presentation] Bidirectional regulation of TASK1 channels expressed in HEK cells by modulation of PKG2011

    • Author(s)
      豊田博紀,齋藤充,岡澤慎,平尾圭子,佐藤元,阿部遙,高田健治,船曳和雄,高田昌彦,金子武嗣,姜英男
    • Organizer
      第88回日本生理学会大会
    • Place of Presentation
      横浜
    • Year and Date
      2011-03-28
    • Data Source
      KAKENHI-PROJECT-21790294
  • [Presentation] The Etv1/Er81 transcription factor regulates activity-dependent gene expression in the terminal maturation program of cerebellar granule cells2011

    • Author(s)
      Abe H, Okazawa M, Nakanishi S
    • Organizer
      第34回日本分子生物学会年回
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2011-12-13
    • Data Source
      KAKENHI-PROJECT-21790294
  • [Presentation] (PKG) bidirectionally modulates TASK1 currents in PKG-loaded HEK 293 cells2010

    • Author(s)
      Toyoda H., Saito M., Okazawa M., Hirao K., Sato H., Abe H., Takada K., Funabiki K., Takada M., Kaneko T., Y. K Protein kinase G
    • Organizer
      Neuroscience the Society for Neuroscience's 40th Annual Meeting
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2010-11-15
    • Data Source
      KAKENHI-PROJECT-21790294
  • [Presentation] Mechanism of subunit switching from NR2B to NR2C in mouse cerebellar ganule cell cultures2009

    • Author(s)
      Kouichirou Iijima, Haruka Abe, Makoto Okazawa et.al.
    • Organizer
      第39回北米神経科学学会年会(Neuroscience 2009, SfN's 39th annual meeting)
    • Place of Presentation
      McCormick Place(Chicago, Illinois, USA)
    • Year and Date
      2009-10-20
    • Data Source
      KAKENHI-PROJECT-21790294
  • [Presentation] Mechanism of subunit switching from NR2B to NR2C in mouse cerebellar granule cell cultures2009

    • Author(s)
      Iijima K, Abe H, Okazawa M, Moriyoshi K, Nakanishi S
    • Organizer
      第39回北米神経科学学会年会(Neuroscience 2009, SfN's 39th annual meeting)
    • Place of Presentation
      McCormick Place(Chicago, Illinois, USA)
    • Year and Date
      2009-10-20
    • Data Source
      KAKENHI-PROJECT-21790294
  • [Presentation] Mechanism of subunit switching from NR2B to NR2C in mouse cerebellar granule cell cultures2009

    • Author(s)
      Iijima K, Abe H, Okazawa M, Moriyoshi K, Nakanishi S
    • Organizer
      第32回日本神経科学会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Year and Date
      2009-09-17
    • Data Source
      KAKENHI-PROJECT-21790294
  • [Presentation] Membrane potential-regulated calcineurin signaling in maturation of cerebellar granule cells2009

    • Author(s)
      Okazawa M, Abe H, Kiwada T, Katsukawa M, Nakanishi S
    • Organizer
      第39回北米神経科学学会年会(Neuroscience 2009, SfN's 39th annual meeting)
    • Place of Presentation
      McCormick Place(Chicago, Illinois, USA)
    • Year and Date
      2009-10-19
    • Data Source
      KAKENHI-PROJECT-21790294
  • [Presentation] Membrane potential-regulated maturation of cerebellar granule cells2009

    • Author(s)
      Makoto Okazawa et.al.
    • Organizer
      第32回日本神経科学大会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Year and Date
      2009-09-16
    • Data Source
      KAKENHI-PROJECT-21790294
  • [Presentation] A pivotal role of calcineurin signaling in membrane potential-regulated terminal maturation of cerebellar granule cells2009

    • Author(s)
      Makoto Okazawa et.al.
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2009-12-10
    • Data Source
      KAKENHI-PROJECT-21790294
  • [Presentation] Membrane potential-regulated calcineurin signaling in maturation of cerebellar grapule cells2009

    • Author(s)
      Makoto Okazawa et.al.
    • Organizer
      第39回北米神経科学学会年会(Neuroscience 2009, SfN's 39th annual meeting)
    • Place of Presentation
      McCormick Place(Chicago, Illinois, USA)
    • Year and Date
      2009-10-19
    • Data Source
      KAKENHI-PROJECT-21790294
  • [Presentation] A pivotal role of calcineurin signaling in membrane potential-regulated terminal maturation of cerebellar granule cells2009

    • Author(s)
      Okazawa M, Abe H, Kiwada T, Katsukawa M, Nakanishi S
    • Organizer
      第32回日本分子生物学会年回
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2009-12-10
    • Data Source
      KAKENHI-PROJECT-21790294
  • [Presentation] Membrane potential-regulated maturation of cerebellar granule cells2009

    • Author(s)
      Okazawa M, Abe H, Kiwada T, Katsukawa M, Nakanishi S
    • Organizer
      第32回日本神経科学会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Year and Date
      2009-09-16
    • Data Source
      KAKENHI-PROJECT-21790294
  • [Presentation] Mechanism of subunit switching from NR2B to NR2C in mouse cerebellar granule cell cultures2009

    • Author(s)
      Kouichirou Iijima, Haruka Abe, Makoto Okazawa et.al.
    • Organizer
      第32回日本神経科学大会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Year and Date
      2009-09-17
    • Data Source
      KAKENHI-PROJECT-21790294
  • [Presentation] LOX-1 遺伝子欠損SHRSPの作製とその形質の予備的解析

    • Author(s)
      垣野明美、李 蕾、池末昌弘、中野厚史、藤田佳子、岡澤 慎、真下知士、沢村達也
    • Organizer
      第50回高血圧関連疾患モデル学会学術総会
    • Place of Presentation
      和歌山
    • Year and Date
      2014-12-05 – 2014-12-06
    • Data Source
      KAKENHI-PROJECT-24790300
  • [Presentation] LOX-1 遺伝子欠損SHRSPの作製とその形質の予備的解析

    • Author(s)
      垣野明美、李 蕾、池末昌弘、中野厚史、藤田佳子、岡澤 慎、真下知士、沢村達也
    • Organizer
      第50回高血圧関連疾患モデル学会学術総会
    • Place of Presentation
      和歌山
    • Year and Date
      2014-12-05 – 2014-12-06
    • Data Source
      KAKENHI-PUBLICLY-25118731
  • [Presentation] cGMP依存性蛋白キナーゼによるTASK電流の調節

    • Author(s)
      齋藤充、田中千恵、古谷和春、岡澤慎、豊田博紀、佐藤元、倉智嘉久、姜英男
    • Organizer
      第37会日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-11 – 2014-09-13
    • Data Source
      KAKENHI-PUBLICLY-25118731
  • [Presentation] cGMP依存性蛋白キナーゼによるTASK電流の調節

    • Author(s)
      齋藤充、田中千恵、古谷和春、岡澤慎、豊田博紀、佐藤元、倉智嘉久、姜英男
    • Organizer
      第37会日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-11 – 2014-09-13
    • Data Source
      KAKENHI-PROJECT-24790300
  • 1.  中岡 良和 (90393214)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 2.  NAKANISHI Shigetada (20089105)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 7 results
  • 3.  YAWATA Satoshi (90455246)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 4.  KIWADA Tatsuto (50414131)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 5.  HIKIDA Takatoshi (70421378)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  DOI Tomokazu (20435564)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  FUNABIKI Kazuo (00301234)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  WADA Norio (90525958)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  水島 沙織 (90910620)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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