YAMANE Shoji 山根昌治

Researcher Number	40419148
Affiliation (based on the past Project Information) *help	2008: 独立行政法人国立病院機構(相模原病院臨床研究センター), 病態総合研究部, 特別研究員 2007: 独立行政法人国立病院機構(相模原病院臨床研究センター), 診断・治療研究部, 研究室長 2007: Clinical Research Center, National Hospital Organization Sagamihara Hospital, Division of Pathomechanisms, PhD, Group Manager 2006: 独立行政法人国立病院機構(相模原病院臨床研究センター), 診断治療研究部, 研究部長
Review Section/Research Field	Except Principal Investigator Orthopaedic surgery
Keywords	Except Principal Investigator 変形性関節症 / インテグリン / Osteoarthritis / Cartilage tissue engineering / Integrin / Dedifferentiation / Chondrocte / ERK / 再生医学 / 脱分化 … More / 軟骨細胞 / 腫瘍破死因子 / 関節リウマチ / 切断酵素 / 腫瘍壊死因子 / 異化反応 / ファイブロネクチン Less

軟骨基質の異化の包括的な制御による変形性関節症の進行抑制に関する基礎的研究
- Principal Investigator
  
  FUKUI Naoshi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Clinical Research Center for Allergy and Rheumatology, National Hospital Organization, Sagamihara National Hospital
Investigation for the mechanism of shedding for tumor necrosis factor-α and its pathological significance in rheumatoid arthritis
- Principal Investigator
  
  HIKITA Atuhiko
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Clinical Research Center for Allergy and Rheumatology, National Hospital Organization, Sagamihara National Hospital
An exploratory research for prevention of chondrocyte dedifferentiation and treatment for osteoarthritis through the regulation of integrin actitivy
- Principal Investigator
  
  FUKUI Naoshi
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Clinical Research Center for Allergy and Rheumatology, National Hospital Organization, Sagamihara National Hospital

All 2008 2007 2006 Other

All Journal Article Presentation

[Journal Article] Regional differences in chondrocyte metabolism in osteoarthritis. A detailed analysis by laser capture microdissection2008
- Author(s)
  Fukui N, Ikeda Y, Ohnuki T, Tanaka S, Yamane S, Suzuki R, Sandell LJ, Ochi T.
- Journal Title
  
  Arthritis Rheum 58
  
  Pages: 154-163
- Data Source
  KAKENHI-PROJECT-19791052
[Journal Article] LIGHT Induces Cell Proliferation and Inflammatory Responses of Rheumatoid Arthritis Synovial Fibroblasts via Lymphotoxin beta Receptor.2008
- Author(s)
  Ishida S, Yamane S, Ochi T, Nakano S, Mori T, Juji T, Fukui N, Itoh T, Suzuki R.
- Journal Title
  
  J Rheumatol. Jun ; 35(6)
  
  Pages: 960-968
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390424
[Journal Article] Regional differences in chondrocyte metabolism in osteoarthritis. A detailed analysis by laser capture microdissection.2008
- Author(s)
  Fukui N, Ikeda Y, Ohnuki T, Tanaka N, Hikita A, Mitomi H, Mori T, Juji T, Katsuragawa Y, Yamamoto S, Sawabe M, Yamane S, Suzuki R, Sandell LJ, Ochi T.
- Journal Title
  
  Arthritis Rheum 58
  
  Pages: 154-163
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390424
[Journal Article] TNF-alpha induces the expression of BMP-2 through transcriptional and post-transcriptional regulatory mechanisms2006
- Author(s)
  Fukui N, Ikeda Y, Ohnuki T, Tanaka N, Hikita A, Mitomi H, Mori T, Juji T, Katsuragawa Y, Yamamoto S, Sawabe M, Yamane S, Suzuki R, Sandell LJ, Ochi T.
- Journal Title
  
  J Biol Chem 281
  
  Pages: 27229-41
- Data Source
  KAKENHI-PROJECT-19791052
[Journal Article] TNF-α induces the expression of BMP-2 through transcriptional and post-transcriptional regulatory mechanisms.2006
- Author(s)
  Fukui N, Ikeda T, Ohnuki T, Tanaka S, Yamane S, Suzuki R, Sandell LT, Ochi T.
- Journal Title
  
  J Biol Chem 281
  
  Pages: 27229-41
- Data Source
  KAKENHI-PROJECT-18390424
[Journal Article] Involvement of a disintegrin and metalloproteinase 10 and 17 in shedding of tumor necrosis factor-α
- Author(s)
  Hikita A, Tanaka N, Yamane S, Ikeda Y, Furukawa H, Tohma S, Suzuki R, Tanaka S, Mitomi H, Fukui N.
- Journal Title
  
  Biochem Cell Biol (in press)
- Data Source
  KAKENHI-PROJECT-19791052
[Journal Article] Proinflammatory role of amphiregulin, an epidermal growth factor family member whose expression is augmented in rheumatoid arthritis patients
- Author(s)
  Yamane S, Fukui N, ほか (14名中11番目)
- Journal Title
  
  Journal of inflammation (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19659394
[Journal Article] Involvement of a disintegrin and metalloproteinase 10 and 17 in shedding of tumor necrosis factor-α
- Author(s)
  Atsuhiko Hikita, Nobuho Tanaka, Shoji Yamane, Yasuko Ikeda, Hiroshi Furukawa, Shigeto Tohma, Ryuji Suzuki, Sakae Tanaka, Hiroyuki Mitomi and Naoshi Fukui
- Journal Title
  
  Biochemistry and Cell Biology (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19791052
[Journal Article] The interaction of monocytes with rheumatoid synovial cells is a key step in LIGHT-mediated inflammatory bone destruction
- Author(s)
  Ishida, S, Yamane S, Nakano S, Yanagimoto T, et al.
- Journal Title
  
  Immunology (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19659394
[Journal Article] Proinflammatory role of amphiregulin, an epidermal growth factor family member whose expression is augmented in rheumatoid arthritis patients.
- Author(s)
  Yamane S, Ishida S, Hanamoto Y, Kumagai K, Masuda R, Tanaka K, Shiobara N, Yamane N, Mori T, Juji T, Fukui N, Itoh T, Ochi T, Suzuki R.
- Journal Title
  
  J Inflamm (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390424
[Journal Article] Proinflammatory role of amphiregulin, an epidermal growth factor family member whose expression is augmented in rheumatoid arthritis patients.
- Author(s)
  Yamane S, Fukui N, et. al.(14名中11番目)
- Journal Title
  
  J Inflamm (in press)
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390424
[Journal Article] Proinflammatory role of amphiregulin, an epidermal growth factor family member whose expression is augmented in rheumatoid arthritis patients
- Author(s)
  Yamane S, Fukui N, ほか (14名中11番目)
- Journal Title
  
  Journal of inflammation (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390424
[Presentation] ヒト変性性関節症罹患軟骨におけるanabolic factorの探索2008
- Author(s)
  福井尚志、池田泰子、大貫俊幸、田中信帆、石田暁、山根昌治、疋田温彦、桂川陽三、山本精三、宮本恵成、鈴木隆二
- Organizer
  第21回日本軟骨代謝学会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-19791052
[Presentation] Identification of possible regulatory molecules for chondrocyte anabolism in osteoarthritic cartilage.2007
- Author(s)
  Fukui N, Ikeda Y, Ohnuki T, Tanaka N, Ishida S, Yamane S, Mitomi H, Hikita A, Yamamoto S, Katsuragawa Y, Suzuki R.
- Organizer
  2007 World Congress on Osteoarthritis.
- Place of Presentation
  Ft. Lauderdale, FL. USA.
- Data Source
  KAKENHI-PROJECT-19659394
[Presentation] Identification of possible regulatory molecules for chondrocyte anabolism in osteoarthritic cartilage2007
- Author(s)
  Fukui N, Ikeda Y, Ohnuki T, Tanaka N, Ishida S, Yamane S, Mitomi H, Hikita A, Yamamoto S, Katsuragawa Y, Suzuki R.
- Organizer
  2007 World Congress on Osteoarthritis
- Place of Presentation
  Lauderdale, FL, USA
- Data Source
  KAKENHI-PROJECT-19791052
[Presentation] Identification of possible regulatory molecules for chondrocyte anabolism in osteoarthritic cartilage.2007
- Author(s)
  Fukui N, Ikeda Y, Ohnuki T, Tanaka N, Ishida S, Yamane S, Mitomi H, Hikita A, Yamamoto S, Katsuragawa Y, Suzuki R.
- Organizer
  2007 World Congress on Osteoarthritis. Ft.
- Place of Presentation
  Lauderdale, FL, USA.
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390424
[Presentation] Identification of possible regulatory molecules for chondrocyte anabolism in osteoarthritic cartilage.2007
- Author(s)
  Fukui N, Ikeda Y, Ohnuki T, Tanaka N, Ishida S, Yamane S, Mitomi H, Hikita A, Yamamoto S, Katsuragawa Y, Suzuki R.
- Organizer
  2007 World Congress on Osteoarthritis.
- Place of Presentation
  Ft. Lauderdale, FL, USA.
- Data Source
  KAKENHI-PROJECT-18390424
[Presentation] Integrin αvβ5 may be responsible for the suppression of cartilage matrix genes and formation of cytoskeletons during dedifferentiation in the monolayer cultured adult human articular chondrocytes2006
- Author(s)
  Fukui N, Ikeda Y, Ohnuki T, Tanaka N, Hikita A, Yamane S, Suzuki R, Ochi T, Katsuragawa Y, Yamamoto S.
- Organizer
  2006 World Congress on Osteoarthritis
- Place of Presentation
  Prague, Czech Republic.
- Data Source
  KAKENHI-PROJECT-19791052

1. FUKUI Naoshi (10251258)

# of Collaborated Projects: 3 results

# of Collaborated Products: 17 results
2. SUZUKI Ryuji (70373470)

# of Collaborated Projects: 3 results

# of Collaborated Products: 14 results
3. HIKITA Atuhiko (60443397)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
4. TANAKA Nobuho (60530920)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
5. FURUKAWA Hiroshi (00372293)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
6. TOUMA Shigeto (50207528)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
7. MITOMI Hiroyuki (90181940)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
8. MASUDA Riako (10416050)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. IKEDA Yasuko

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results

YAMANE Shoji 山根 昌治

Research Projects

Research Products

Co-Researchers

軟骨基質の異化の包括的な制御による変形性関節症の進行抑制に関する基礎的研究

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Investigation for the mechanism of shedding for tumor necrosis factor-α and its pathological significance in rheumatoid arthritis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

An exploratory research for prevention of chondrocyte dedifferentiation and treatment for osteoarthritis through the regulation of integrin actitivy

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Regional differences in chondrocyte metabolism in osteoarthritis. A detailed analysis by laser capture microdissection2008

Author(s)

Journal Title

Data Source

[Journal Article] LIGHT Induces Cell Proliferation and Inflammatory Responses of Rheumatoid Arthritis Synovial Fibroblasts via Lymphotoxin beta Receptor.2008

Author(s)

Journal Title

Description

Data Source

[Journal Article] Regional differences in chondrocyte metabolism in osteoarthritis. A detailed analysis by laser capture microdissection.2008

Author(s)

Journal Title

Description

Data Source

[Journal Article] TNF-alpha induces the expression of BMP-2 through transcriptional and post-transcriptional regulatory mechanisms2006

Author(s)

Journal Title

Data Source

[Journal Article] TNF-α induces the expression of BMP-2 through transcriptional and post-transcriptional regulatory mechanisms.2006

Author(s)

Journal Title

Data Source

[Journal Article] Involvement of a disintegrin and metalloproteinase 10 and 17 in shedding of tumor necrosis factor-α

Author(s)

Journal Title

Data Source

[Journal Article] Proinflammatory role of amphiregulin, an epidermal growth factor family member whose expression is augmented in rheumatoid arthritis patients

Author(s)

Journal Title

Data Source

[Journal Article] Involvement of a disintegrin and metalloproteinase 10 and 17 in shedding of tumor necrosis factor-α

Author(s)

Journal Title

Data Source

[Journal Article] The interaction of monocytes with rheumatoid synovial cells is a key step in LIGHT-mediated inflammatory bone destruction

Author(s)

Journal Title

Data Source

[Journal Article] Proinflammatory role of amphiregulin, an epidermal growth factor family member whose expression is augmented in rheumatoid arthritis patients.

Author(s)

Journal Title

Description

Data Source

[Journal Article] Proinflammatory role of amphiregulin, an epidermal growth factor family member whose expression is augmented in rheumatoid arthritis patients.

Author(s)

Journal Title

Description

Data Source

[Journal Article] Proinflammatory role of amphiregulin, an epidermal growth factor family member whose expression is augmented in rheumatoid arthritis patients

Author(s)

Journal Title

Data Source

[Presentation] ヒト変性性関節症罹患軟骨におけるanabolic factorの探索2008

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] Identification of possible regulatory molecules for chondrocyte anabolism in osteoarthritic cartilage.2007

YAMANE Shoji 山根昌治