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MORISHIMA TATSUYA  森嶋 達也

… Alternative Names

Morishima Tatsuya  森嶋 達也

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Researcher Number 40421375
Other IDs
  • ORCIDhttps://orcid.org/0000-0003-3876-3217
Affiliation (Current) 2025: 熊本大学, 国際先端医学研究機構, 特任講師
Affiliation (based on the past Project Information) *help 2022 – 2023: 熊本大学, 国際先端医学研究機構, 特任講師
2019 – 2021: 熊本大学, 国際先端医学研究機構, 特任助教
Review Section/Research Field
Principal Investigator
Basic Section 54010:Hematology and medical oncology-related
Except Principal Investigator
Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
Keywords
Principal Investigator
抗炎症薬 / ドラッグ・リポジショニング / 脂肪酸代謝 / 薬剤耐性 / IDH遺伝子変異 / 急性骨髄性白血病 / T-ALL / タンパク質アセチル化 / 造血幹細胞 / 代謝 … More / Sirtuin / NAMPT / NAD+ / LMO2 / アセチル化 / 白血病 … More
Except Principal Investigator
赤血球造血 Less
  • Research Projects

    (3 results)
  • Research Products

    (31 results)
  • Co-Researchers

    (3 People)
  •  tRNA修飾異常を起点とした赤血球プロテオスタシスの破綻

    • Principal Investigator
      滝澤 仁
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
    • Research Institution
      Kumamoto University
  •  Elucidation of leukemia clone survival mechanism via lipid metabolic adaptationPrincipal Investigator

    • Principal Investigator
      Morishima Tatsuya
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 54010:Hematology and medical oncology-related
    • Research Institution
      Kumamoto University
  •  Development of novel therapy for leukemia targeting metabolism-dependent protein modificationPrincipal Investigator

    • Principal Investigator
      Morishima Tatsuya
    • Project Period (FY)
      2019 – 2020
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 54010:Hematology and medical oncology-related
    • Research Institution
      Kumamoto University

All 2024 2023 2022 2021 2020 2019

All Journal Article Presentation

  • [Journal Article] GPRC5C drives branched-chain amino acid metabolism in leukemogenesis2023

    • Author(s)
      Zhang YW, ... , Morishima T, ... , Cabezas-Wallscheid N.
    • Journal Title

      Blood Advances

      Volume: 7 Issue: 24 Pages: 7525-7538

    • DOI

      10.1182/bloodadvances.2023010460

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K08397
  • [Journal Article] Humanized mouse models with endogenously developed human natural killer cells for in?vivo immunogenicity testing of HLA class I-edited iPSC-derived cells2023

    • Author(s)
      Flahou Charlotte、Morishima Tatsuya、Higashi Natsumi、Hayashi Yoshikazu、Xu Huaigeng、Wang Bo、Zhang Chaoqi、Ninomiya Atsushi、Qiu Wei-Yin、Yuzuriha Akinori、Suzuki Daisuke、Nakamura Sou、Manz Markus、Kaneko Shin、Hotta Akitsu、Takizawa Hitoshi、Eto Koji、Sugimoto Naoshi
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 662 Pages: 76-83

    • DOI

      10.1016/j.bbrc.2023.04.067

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K18299, KAKENHI-PROJECT-21K08397, KAKENHI-PROJECT-21K08413, KAKENHI-PROJECT-21H05047
  • [Journal Article] Akkermansia muciniphila induces slow extramedullary hematopoiesis via cooperative IL‐1R/TLR signals2023

    • Author(s)
      Wang Yuxin、Morishima Tatsuya、Sezaki Maiko、Sato Ryo、Nakato Gaku、Fukuda Shinji、Kobiyama Kouji、Ishii Ken J、Li Yuhua、Takizawa Hitoshi
    • Journal Title

      EMBO reports

      Volume: 24 Issue: 12

    • DOI

      10.15252/embr.202357485

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K08397
  • [Journal Article] Phospholipid metabolic adaptation promotes survival of IDH2 mutant acute myeloid leukemia cells2023

    • Author(s)
      Morishima Tatsuya、Takahashi Koichi、Chin Desmond Wai Loon、Wang Yuxin、Tokunaga Kenji、Arima Yuichiro、Matsuoka Masao、Suda Toshio、Takizawa Hitoshi
    • Journal Title

      Cancer Science

      Volume: 115 Issue: 1 Pages: 197-210

    • DOI

      10.1111/cas.15994

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K08397
  • [Journal Article] Unique molecular and functional features of extramedullary hematopoietic stem and progenitor cell reservoirs in humans.2022

    • Author(s)
      Mende N, Bastos HP, Santoro A, Mahbubani KT, Ciaurro V, Calderbank EF, Quiroga Londono M, Sham K, Mantica G, Morishima T, Mitchell E, Lidonnici MR, Meier-Abt F, Hayler D, Jardine L, Curd A, Haniffa M, Ferrari G, Takizawa H, Wilson NK, Gottgens B, Saeb-Parsy K, Frontini M, Laurenti E.
    • Journal Title

      Blood

      Volume: - Issue: 23 Pages: 3387-3401

    • DOI

      10.1182/blood.2021013450

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K08397
  • [Journal Article] Hematopoietic stem and progenitor cells integrate microbial signals to promote post‐inflammation gut tissue repair2022

    • Author(s)
      Sezaki Maiko、Hayashi Yoshikazu、Nakato Gaku、Wang Yuxin、Nakata Sayuri、Biswas Subinoy、Morishima Tatsuya、Fakruddin Md、Moon Jieun、Ahn Soyeon、Kim Pilhan、Miyamoto Yuji、Baba Hideo、Fukuda Shinji、Takizawa Hitoshi
    • Journal Title

      The EMBO Journal

      Volume: 41 Issue: 22

    • DOI

      10.15252/embj.2022110712

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K08397, KAKENHI-PROJECT-20K17381
  • [Journal Article] Fit-For-All iPSC-Derived Cell Therapies and Their Evaluation in Humanized Mice With NK Cell Immunity.2021

    • Author(s)
      Flahou C, Morishima T, Takizawa H, Sugimoto N.
    • Journal Title

      Front Immunol

      Volume: 12 Pages: 662360-662360

    • DOI

      10.3389/fimmu.2021.662360

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K08397, KAKENHI-PROJECT-21K08413
  • [Journal Article] NAMPT/SIRT2-mediated inhibition of the p53-p21 signaling pathway is indispensable for maintenance and hematopoietic differentiation of human iPS cells2021

    • Author(s)
      Xu Yun、Nasri Masoud、Dannenmann Benjamin、Mir Perihan、Zahabi Azadeh、Welte Karl、Morishima Tatsuya*#、Skokowa Julia*#. (*corresponding authors; #equally contribution)
    • Journal Title

      Stem Cell Research & Therapy

      Volume: 12 Issue: 1

    • DOI

      10.1186/s13287-021-02144-9

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K17833
  • [Journal Article] iPSC modeling of stage-specific leukemogenesis reveals BAALC as a key oncogene in severe congenital neutropenia.2021

    • Author(s)
      Dannenmann B, Klimiankou M, Oswald B, Solovyeva A, Mardan J, Nasri M, Ritter M, Zahabi A, Arreba-Tutusaus P, Mir P, Stein F, Kandabarau S, Lachmann N, Moritz T, Morishima T, Konantz M, Lengerke C, Ripperger T, Steinemann D, Erlacher M, Niemeyer CM, Zeidler C, Welte K, Skokowa J.
    • Journal Title

      Cell Stem Cell

      Volume: 28(5) Issue: 5 Pages: 906-922

    • DOI

      10.1016/j.stem.2021.03.023

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K08397
  • [Journal Article] Genetic fingerprint defines hematopoietic stem cell pool size and function.2020

    • Author(s)
      Morishima T*, Takizawa H*.(*corresponding authors)
    • Journal Title

      Haematologica

      Volume: 105(3) Issue: 3 Pages: 526-528

    • DOI

      10.3324/haematol.2019.241299

    • Open Access
    • Data Source
      KAKENHI-PROJECT-19K17833
  • [Journal Article] LMO2 activation by deacetylation is indispensable for hematopoiesis and T-ALL leukemogenesis.2019

    • Author(s)
      Morishima T*, Krahl AC, Nasri M, Xu Y, Aghaallaei N, Findik B, Klimiankou M, Ritter M, Hartmann MD, Gloeckner CJ, Stefanczyk S, Lindner C, Oswald B, Bernhard R, Haehnel K, Hermanutz-Klein U, Ebinger M, Handgretinger R, Casadei N, Welte K, Andre M, Mueller P, Bajoghli B, Skokowa J*. (*corresponding authors)
    • Journal Title

      Blood

      Volume: 134(14) Issue: 14 Pages: 1159-1175

    • DOI

      10.1182/blood.2019000095

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K17833
  • [Presentation] Establishing a novel culture system for lymphoid-biased human HSC induction.2024

    • Author(s)
      Wang Y, Morishima T, Khalilnezhad A, Suda T, Takizawa H.
    • Organizer
      The Keystone Hematopoiesis
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K08397
  • [Presentation] Mitochondrial translation regulates fetal erythropoiesis through regulation of iron homeostasis.2024

    • Author(s)
      Morishima T, Fakruddin M, Masuda T, Wang Y, Schoonenberg VAC, Butter F, Arima Y, Akaike T, Tomizawa K, Wei FY, Suda T, Takizawa H.
    • Organizer
      The Keystone Hematopoiesis
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K08397
  • [Presentation] tRNA 修飾による造血制御2024

    • Author(s)
      森嶋 達也
    • Organizer
      遺伝研研究会「エピトランスクリプトーム制御の分子機構と生理機能」
    • Invited
    • Data Source
      KAKENHI-PROJECT-21K08397
  • [Presentation] ミトコンドリアtRNA修飾による赤血球分化制御2023

    • Author(s)
      森嶋 達也
    • Organizer
      赤血球研究シンポジウム-基礎から応用へ-
    • Invited
    • Data Source
      KAKENHI-PROJECT-21K08397
  • [Presentation] Erythroid differentiation is mediated by mitochondrial translation and its regulation of iron homeostasis.2023

    • Author(s)
      Morishima T, Fakruddin M, Masuda T, Wang Y, Schoonenberg VAC, Butter F, Arima Y, Tomizawa K, Wei FY, Suda T, Takizawa H.
    • Organizer
      Lund Stem Cell Center 20th Anniversary Conference.
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K08397
  • [Presentation] Terminal erythroid differentiation is mediated by mitochondrial translation through regulation of iron homeostasis2023

    • Author(s)
      Tatsuya Morishima, Md. Fakruddin, Takeshi Masuda, Yuxin Wang, Vivien A. C. Schoonenberg, Falk Butter, Yuichiro Arima, Kazuhito Tomizawa, Fan-Yan Wei, Toshio Suda, Hitoshi Takizawa
    • Organizer
      第20回幹細胞シンポジウム
    • Data Source
      KAKENHI-PROJECT-21K08397
  • [Presentation] Terminal erythroid differentiation is regulated by mitochondrial translation via maintenance of iron homeostasis2022

    • Author(s)
      Tatsuya Morishima, Md. Fakruddin, Takeshi Masuda, Yuxin Wang, Vivien A. C. Schoonenberg, Falk Butter, Yuichiro Arima, Kazuhito Tomizawa, Fan-Yan Wei, Toshio Suda, Hitoshi Takizawa
    • Organizer
      The 64th ASH Annual Meeting and Exposition
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K19548
  • [Presentation] Mitochondrial tRNA modification regulates erythroid differentiation via maintenance of intracellular iron homeostasis2022

    • Author(s)
      Tatsuya Morishima, Md. Fakruddin, Takeshi Masuda, Yuxin Wang, Vivien A. C. Schoonenberg, Falk Butter, Yuichiro Arima, Kazuhito Tomizawa, Fan-Yan Wei, Toshio Suda, Hitoshi Takizawa
    • Organizer
      The 51st Annual Scientific Meeting of International Society for Experimental Hematology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K08397
  • [Presentation] ミトコンドリアtRNA修飾による細胞内鉄動態を介した赤血球分化制御2022

    • Author(s)
      森嶋 達也、Md. Fakruddin、増田 豪、Yuxin Wang、Vivien A. C. Schoonenberg、Falk Butter、有馬 勇一郎、富澤 一仁、Fan-Yan Wei、須田 年生、滝澤 仁
    • Organizer
      第84回日本血液学会学術集会
    • Data Source
      KAKENHI-PROJECT-21K08397
  • [Presentation] Oncometabolite-independent anti-apoptotic feature via phospholipid metabolic adaptation in IDH2 mutant AML cells2022

    • Author(s)
      Tatsuya Morishima, Koichi Takahashi, Desmond Wai Loon Chin, Kenji Tokunaga, Yuichiro Arima, Masao Matsuoka, Toshio Suda, Hitoshi Takizawa
    • Organizer
      The 64th ASH Annual Meeting and Exposition
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K08397
  • [Presentation] Mitochondrial tRNA modification regulates erythroid differentiation by maintaining iron homeostasis2022

    • Author(s)
      Tatsuya Morishima, Md. Fakruddin, Takeshi Masuda, Yuxin Wang, Vivien A. C. Schoonenberg, Falk Butter, Yuichiro Arima, Kazuhito Tomizawa, Fan-Yan Wei, Toshio Suda, Hitoshi Takizawa
    • Organizer
      The 84th Annual Meeting of Japanese Society of Hematology
    • Data Source
      KAKENHI-PROJECT-22K19548
  • [Presentation] Mitochondrial tRNA modification regulates terminal erythroid differentiation2022

    • Author(s)
      Tatsuya Morishima
    • Organizer
      The 5th KU-KAIST Joint Symposium
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K08397
  • [Presentation] Terminal erythroid differentiation is regulated by mitochondrial translation via maintenance of iron homeostasis2022

    • Author(s)
      Tatsuya Morishima, Md. Fakruddin, Takeshi Masuda, Yuxin Wang, Vivien A. C. Schoonenberg, Falk Butter, Yuichiro Arima, Kazuhito Tomizawa, Fan-Yan Wei, Toshio Suda, Hitoshi Takizawa
    • Organizer
      The 64th ASH Annual Meeting and Exposition
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K08397
  • [Presentation] 脂肪酸代謝適応を介したIDH2変異AML細胞のアポトーシス耐性獲得2021

    • Author(s)
      森嶋 達也, 高橋 康一, Desmond Chin, 徳永 賢治, 松岡 雅雄, 須田 年生, 滝澤 仁
    • Organizer
      第83回日本血液学会学術集会
    • Data Source
      KAKENHI-PROJECT-21K08397
  • [Presentation] Taurine modification of mitochondrial tRNAs regulates fetal erythropoiesis via ER stress response2021

    • Author(s)
      Tatsuya Morishima, Md. Fakruddin, Takeshi Masuda, Vivien Schoonenberg, Falk Butter, Yuichiro Arima, Kenichi Tsujita, Fan-Yan Wei, Hitoshi Takizawa
    • Organizer
      第44回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-21K08397
  • [Presentation] 脂質代謝適応獲得によるIDH変異白血病の生存メカニズムの解明2021

    • Author(s)
      森嶋 達也, Desmond Chin, 高橋 康一,徳永 賢治, 松岡 雅雄, 須田 年生, 滝澤 仁
    • Organizer
      第25回造血器腫瘍研究会
    • Data Source
      KAKENHI-PROJECT-19K17833
  • [Presentation] Phospholipid metabolism adaptation induces drug resistance in IDH mutant AML cells2021

    • Author(s)
      Tatsuya Morishima, Koichi Takahashi, Desmond Chin, Kenji Tokunaga, Masao Matsuoka, Toshio Suda, Hitoshi Takizawa
    • Organizer
      第18回幹細胞シンポジウム
    • Data Source
      KAKENHI-PROJECT-21K08397
  • [Presentation] アラキドン酸低下を介したIDH関連オンコメタボライト非依存性AML細胞増殖2020

    • Author(s)
      森嶋 達也, Desmond Chin, 高橋 康一, 有田 誠,徳永 賢治, 松岡 雅雄, 須田 年生, 滝澤 仁
    • Organizer
      第82回日本血液学会学術集会
    • Data Source
      KAKENHI-PROJECT-19K17833
  • [Presentation] 正常および悪性造血における代謝制御の解析2019

    • Author(s)
      森嶋達也 高橋康一, 徳永賢治, 松岡雅雄, 須田年生, 滝澤仁
    • Organizer
      第81回日本血液学会学術集会
    • Data Source
      KAKENHI-PROJECT-19K17833
  • [Presentation] LMO2 activation by NAMPT-NAD+-SIRT2 pathway mediated deacetylation is indispensable for early hematopoiesis and T-ALL leukemogenesis2019

    • Author(s)
      Morishima T, Krahl AC, Xu Y, Aghaallaei N, Nasri M, Klimiankou M, Ritter M, Hartmann MD, Findik B, Stefanczyk S, Lindner C, Oswald B, Bernhard R, Haehnel K, Hermanutz-Klein U, Kanz L, Bajoghli B, Andre M, Mueller P, Welte K, Skokowa J
    • Organizer
      第17回幹細胞シンポジウム
    • Data Source
      KAKENHI-PROJECT-19K17833
  • 1.  滝澤 仁 (10630866)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 2.  増田 豪 (70383940)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 3.  江藤 浩之
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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