KAWAI Tomoko 河合智子

… Alternative Names

TOMOKO Kawai 河合智子

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Researcher Number	40423404
Other IDs
Affiliation (Current)	2025: 国立研究開発法人国立成育医療研究センター, 周産期病態研究部, 室長
Affiliation (based on the past Project Information) *help	2016 – 2024: 国立研究開発法人国立成育医療研究センター, 周産期病態研究部, 室長 2015: 国立研究開発法人国立成育医療研究センター, その他部局等, 研究員 2013 – 2014: 独立行政法人国立成育医療研究センター, その他部局等, 研究員 2013: 独立行政法人国立成育医療研究センター, 周産期病態研究部, 研究員 2012: 独立行政法人国立成育医療研究センター, 周産期病態研究部, 共同研究員 … More 2010: National Institute of Health and Nutrition, 研究員 2009: The University of Tokushima, 大学院・ヘルスバイオソイエンス研究部, 講師 2008 – 2009: The University of Tokushima, 大学院・ヘルスバイオサイエンス研究部, 講師 2007: The University of Tokushima, 大学院・ヘルスパイオサイエンス研究部, 講師 2006: 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 助手 Less
Review Section/Research Field	Principal Investigator Basic Section 59040:Nutrition science and health science-related / Eating habits / Gastroenterology / Obstetrics and gynecology / Metabolomics Except Principal Investigator Basic Section 53050:Dermatology-related / Basic Section 52050:Embryonic medicine and pediatrics-related / Basic Section 56040:Obstetrics and gynecology-related / Gastroenterology
Keywords	Principal Investigator 出生体重 / 胎児発育 / 胎盤 / DNAメチル化 / エピゲノム / 臍帯血エピゲノム / 胎児期環境 / 胎児期栄養環境 / 臍帯血 / 妊娠期体重増加量 … More / 胎児エピゲノム / 子宮内栄養環境 / 栄養 / ヒト胎盤 / 細胞増殖 / 選択的スプライシング / ストレス応答 / 転写後調節 / エピアレル / 胎児環境 / 栄養摂取 / 子宮内環境 / 胎盤エピゲノム / 臍帯血DNAメチル化 / 周産期環境 / DNAメチル化変化 / 胎児期栄養 / エピトランスクリプトーム / RNAメチル化 / 周産期 / エピジェネティックス / 上部消化管学(食道、胃、十二指腸) / RNA結合タンパク質 / 発現制御 / ストレス … More Except Principal Investigator エピゲノム / 遺伝子 / 角層バリア / 小児 / アトピー性皮膚炎 / エピゲノム変異 / エピゲノム多型 / DOHaD / 生殖補助医療 / DoHaD / インスリン感受性 / インスリン抵抗性 / 網羅的解析 / メチル化 / 臍帯血DNA / 糖代謝異常 / エピジェネティクス / DOHaD仮説 / 新生児低血糖 / エピゲノム変化 / 臍帯血メチル化 / 妊娠糖尿病 / VEGF / 悪性化 / 機能性RNA / 大腸がん Less

エピゲノム変異不均一性を指標にした初期胚・胎児期環境のエピゲノムへの影響評価
- Principal Investigator
  
  秦健一郎
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Gunma University
Analysis of stratum corneum barrier and genes for stratification of pediatric atopic dermatitis patients
- Principal Investigator
  
  吉田和恵
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53050:Dermatology-related
- Research Institution
  National Center for Child Health and Development
Assessment of fetal nutritional environmentPrincipal Investigator
- Principal Investigator
  
  河合智子
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  National Center for Child Health and Development
Epigenetic changes in neonates born to Japanese mothers with gestational diabetes
- Principal Investigator
  
  Miyakoshi Kei
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Keio University
The effects of in-uterine environment on infant health other than birth weightPrincipal Investigator
- Principal Investigator
  
  Kawai Tomoko
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  National Center for Child Health and Development
Research for the effects of fetal nutritional environment on epigenetic regulationPrincipal Investigator
- Principal Investigator
  
  Tomoko Kawai
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Eating habits
- Research Institution
  National Center for Child Health and Development
Identification of diet contents regulating RNA methylation and those effects on fetal growthPrincipal Investigator
- Principal Investigator
  
  Kawai Tomoko
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Eating habits
- Research Institution
  National Center for Child Health and Development
The mechanism of aberrant gene expressions in adulthood caused by fetal and neonatal nutrition status.Principal Investigator
- Principal Investigator
  
  TOMOKO Kawai
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  National Research Institute for Child Health and Development
インスリン受容体基質が膵β細胞増殖に果たす役割の解明Principal Investigator
- Principal Investigator
  
  河合智子
- Project Period (FY)
  2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Metabolomics
- Research Institution
  National Institute of Health and Nutrition
VEGFmRNAに内在された新たな大腸がん進展機構
- Principal Investigator
  
  増田清士
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokushima
Elucidation of function of tra2 beta alternative splicing mRNA isoformPrincipal Investigator
- Principal Investigator
  
  KAWAI Tomoko
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokushima
Tra2bトランスレーションバリアントによる胃粘膜細胞ストレス応答の分子機構Principal Investigator
- Principal Investigator
  
  河合智子
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokushima

All 2023 2022 2021 2019 2018 2017 2016 2015 2013 2009

All Journal Article Presentation Book

[Book] ヒューマンインターフェースのための計測と制御、第4章ストレス応答の分子機構2009
- Author(s)
  河合智子
- Total Pages
  15
- Publisher
  シーエムシー出版
- Data Source
  KAKENHI-PROJECT-20790497
[Journal Article] DNA methylation analysis of cord blood samples in neonates born to gestational diabetes mothers diagnosed before 24 gestational weeks.2022
- Author(s)
  Kasuga Y, Kawai T, Miyakoshi K, Hori A, Tamagawa M, Hasegawa K, Ikenoue S, Ochiai D, Saisho Y, Hida M, Tanaka M, Hata K
- Journal Title
  
  BMJ Open Diabetes Res Care.
  
  Volume: 10 Issue: 1 Pages: e002539-e002539
- DOI
  10.1136/bmjdrc-2021-002539
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K11735
[Journal Article] Identification of epigenetic memory candidates associated with gestational age at birth through analysis of methylome and transcriptional data2021
- Author(s)
  Kashima Kohei, Kawai Tomoko, 共同筆頭著者、他22名
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 3381-3381
- DOI
  10.1038/s41598-021-83016-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K11735, KAKENHI-PROJECT-17K08689, KAKENHI-PROJECT-20K16916
[Journal Article] Epigenetic Changes in Neonates Born to Mothers With Gestational Diabetes Mellitus May Be Associated With Neonatal Hypoglycaemia2021
- Author(s)
  Kasuga Yoshifumi、Kawai Tomoko、Miyakoshi Kei、Saisho Yoshifumi、Tamagawa Masumi、Hasegawa Keita、Ikenoue Satoru、Ochiai Daigo、Hida Mariko、Tanaka Mamoru、Hata Kenichiro
- Journal Title
  
  Frontiers in Endocrinology
  
  Volume: 12 Pages: 690648-690648
- DOI
  10.3389/fendo.2021.690648
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09761, KAKENHI-PROJECT-19K11735
[Journal Article] Lists of HumanMethylation450 BeadChip probes with nucleotide-variant information obtained from the Phase 3 data of the 1000 Genomes Project.2015
- Author(s)
  Okamura K, Kawai T, Hata K, Nakabayashi K.
- Journal Title
  
  Genomics data
  
  Volume: 7 Pages: 67-9
- DOI
  10.1016/j.gdata.2015.11.023
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26560076, KAKENHI-PROJECT-16K07137
[Journal Article] DNA methylation analysis of human myoblasts during in vitro myogenic differentiation: de novo methylation of promoters of muscle-related genes and its involvement in transcriptional down-regulation2015
- Author(s)
  Miyata K, Miyata T, Nakabayashi K, Okamura K, Naito M, Kawai T, Takada S, Kato K, Miyamoto S, Hata K, Asahara H
- Journal Title
  
  Hum. Mol. Genet.
  
  Volume: 24 Issue: 2 Pages: 410-423
- DOI
  10.1093/hmg/ddu457
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23770273, KAKENHI-PROJECT-25460409, KAKENHI-PROJECT-26560076, KAKENHI-ORGANIZER-26113001, KAKENHI-PLANNED-26113008, KAKENHI-PROJECT-15H02560
[Journal Article] Increased epigenetic alterations at the promoters of transcriptional regulators following inadequate maternal gestational weight gain.2015
- Author(s)
  Kawai T, Yamada T, Abe K, Okamura K, Kamura H, Akaishi R, Minakami H, Nakabayashi K, Hata K.
- Journal Title
  
  Scientific reports
  
  Volume: 5 Issue: 1 Pages: 14224-14224
- DOI
  10.1038/srep14224
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26560076
[Journal Article] Gene expression profiling of white adipose tissue reveals paternal transmission of proneness to obesity.2015
- Author(s)
  Morita S, Nakabayashi K, Kawai T, Hayashi K, Horii T, Kimura M, Kamei Y, Ogawa Y, Hata K, Hatada I
- Journal Title
  
  Sci. Rep.
  
  Volume: 6 Issue: 1 Pages: 21693-21693
- DOI
  10.1038/srep21693
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25460409, KAKENHI-PROJECT-26560076, KAKENHI-PROJECT-15K14432, KAKENHI-PROJECT-25292076, KAKENHI-PROJECT-16H04926, KAKENHI-PROJECT-15K12669, KAKENHI-PROJECT-16K07194
[Journal Article] Oxidative stress-induced alternative splicing of transformer 2beta (SFRS10) and CD44 pre-mRNAs in gastric epithelial cells2009
- Author(s)
  Takeo K, Kawai T, Nishida K, Masuda K, Teshima-Kondo S, Tanahashi T, Rokutan K
- Journal Title
  
  American Journal of Physiology. Cell Physiology Vol.297,No.2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790497
[Presentation] ARTにより出生した児で認められるDNAメチル化変化2023
- Author(s)
  河合智子、関戸雄貴、堀川玲子、秦健一郎
- Organizer
  第11回日本DOHaD学会学術集会
- Data Source
  KAKENHI-PROJECT-22K11793
[Presentation] 数10年単位の栄養学2022
- Author(s)
  河合智子
- Organizer
  日本時間栄養学会
- Invited
- Data Source
  KAKENHI-PROJECT-19K11735
[Presentation] 出生児に観察されるエピジェネティック多型およびその確立に関連する胎児期環境因子の同定2021
- Author(s)
  加藤　友花、河合　智子、堀　あすか、鹿嶋　晃平、春日　義史、堀川　玲子、秦　健一郎
- Organizer
  第10回日本DOHaD学会学術集会
- Data Source
  KAKENHI-PROJECT-19K11735
[Presentation] 周産期環境が倹約型体質獲得に及ぼす影響の機構解明2021
- Author(s)
  河合　智子、鹿嶋　晃平、春日　義史、加藤　友花、秦　健一郎
- Organizer
  第10回日本DOHaD学会学術集会
- Data Source
  KAKENHI-PROJECT-19K11735
[Presentation] Identification of epigenetic changes at birth in human that perinatal environment factors associate2021
- Author(s)
  Tomoko Kawai, Tomoka Kato, Kohei Kashima, Yoshifumi Kasuga, Kei Miyakoshi, Reiko Horikawa, Kenichiro Hata
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K11735
[Presentation] Well-controlled gestational diabetes eliminates DNA methylation changes in cord blood cells associated with hyperglycemia and metabolic disorders in neonates.2019
- Author(s)
  Kasuga Y, Kawai T, Miyakoshi K, Tanaka M, Hata K
- Organizer
  DOHaD 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09761
[Presentation] The correlation between epigenetic change and neonatal plasma glucose level in maternal gestational diabetes offspring2019
- Author(s)
  Kasuga Y, Kawai T, Miyakoshi K, Hata K, Tanaka M
- Organizer
  RCOG World Congress 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09761
[Presentation] 妊娠前の母親のBMIが児のエピゲノムに遺残する可能性の検討2019
- Author(s)
  河合智子、鹿嶋晃平、春日義史、宮越　敬、田中　守、高橋尚人、秦健一郎
- Organizer
  第8回日本DOHaD学会学術集会
- Data Source
  KAKENHI-PROJECT-19K11735
[Presentation] 胎児期栄養環境と関連するエピジェネティック制御2018
- Author(s)
  河合智子、春日義史、宮越敬、田中守、秦健一郎
- Organizer
  日本栄養・食糧学会
- Data Source
  KAKENHI-PROJECT-16K00898
[Presentation] 胎児期栄養環境と関連するエピジェネティック制御2018
- Author(s)
  河合　智子、春日　義史、宮越　敬、田中　守、秦　健一郎
- Organizer
  第72回日本栄養・食糧学会大会
- Data Source
  KAKENHI-PROJECT-16K00898
[Presentation] The placental epi-transcriptome： post-transcriptional m6A modification at 5' UTR may relate fetal growth2017
- Author(s)
  Kosuke Taniguchi, Tomoko Kawai, Nakabayashi Kazuhiko, Kohji Okamura, Jo Kitawaki, Haruhiko Sago, Kenichiro Hata
- Organizer
  国際胎盤学会　IFPA
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K00898
[Presentation] 子宮内環境とエピゲノム状態の変化2017
- Author(s)
  河合智子
- Organizer
  日本赤ちゃん学会
- Invited
- Data Source
  KAKENHI-PROJECT-16K00898
[Presentation] Placental epigenome vary in relation to inadequate gestational weight gain2016
- Author(s)
  Tomoko Kawai, Takahiro Yamada, Kosei Abe, Kohji Okamura, Hiromi Kamura, Rina Akaishi, Hisanori Minakami, Kazuhiko Nakabayashi, Kenichiro Hata
- Organizer
  The 13th International Congress of Human Genetics
- Place of Presentation
  京都　国立京都国際会館
- Year and Date
  2016-04-05
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26560076
[Presentation] 早産児およびSGA児における臍帯血・生後末梢血検体を用いた網羅的メチル化解析2016
- Author(s)
  鹿嶋晃平、河合智子、西村力、嘉村浩美、土田晋也、永松健、藤井知行、大森意策、清水光政、兵藤博信、久具宏司、水口雅、中林一彦、秦健一郎、高橋尚人
- Organizer
  第5回日本DOHaD研究会学術集会
- Place of Presentation
  国立成育医療研究センター
- Year and Date
  2016-07-23
- Data Source
  KAKENHI-PROJECT-16K00898
[Presentation] Inadequate Maternal Gestational Weight Gain Increased Epigenetic Alterations at the Promoters of Transcriptional Regulators in Placenta2016
- Author(s)
  Tomoko Kawai, Takahiro Yamada, Kosei Abe, Kohji Okamura, Hiromi Kamura, Rina Akaishi, Hisanori Minakami, Kazuhiko Nakabayashi, & Kenichiro Hata
- Organizer
  The 13th International Congress of Human Genetics
- Place of Presentation
  国立京都国際会館
- Year and Date
  2016-04-03
- Data Source
  KAKENHI-PROJECT-16K00898
[Presentation] Epitranscriptome of human placental tissue.2016
- Author(s)
  Taniguchi K, Kawai T, Okamura K, Ogata H, Ohashi M, Nakabayashi K, Hata K
- Organizer
  RNA 2016
- Place of Presentation
  京都国際会館
- Year and Date
  2016-06-30
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26560076
[Presentation] 妊娠中の体重増加量と胎盤エピゲノム変化2015
- Author(s)
  河合智子、山田崇弘、安部晃生、岡村浩司、嘉村浩美、赤石理奈、水上尚典、中林一彦、秦健一郎
- Organizer
  日本人類遺伝学会
- Place of Presentation
  東京　京王プラザホテル
- Year and Date
  2015-10-16
- Data Source
  KAKENHI-PROJECT-26560076
[Presentation] 妊娠期体重変化量と胎盤ゲノムDNAのエピジェネティック調節2013
- Author(s)
  河合智子
- Organizer
  日本DOHaD研究会
- Place of Presentation
  厚生労働省戸山研究庁舎
- Data Source
  KAKENHI-PROJECT-24890299
[Presentation] 妊娠期エネルギー摂取量と胎盤ゲノムDNAエピジェネティック変化2013
- Author(s)
  河合智子
- Organizer
  日本栄養改善学会
- Place of Presentation
  神戸国際会議場
- Data Source
  KAKENHI-PROJECT-24890299

1. 秦健一郎 (60360335)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
2. Miyakoshi Kei (70265883)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
3. 増田清士 (00457318)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 六反一仁 (10230898)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 近藤茂忠 (40304513)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 田嶋敦 (10396864)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 荒田尚子 (70214723)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 吉田和恵 (70383776)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. Taniguchi Kosuke

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
10. 岡村浩司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 中林一彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KAWAI Tomoko 河合 智子

TOMOKO Kawai 河合 智子

Research Projects

Research Products

Co-Researchers

エピゲノム変異不均一性を指標にした初期胚・胎児期環境のエピゲノムへの影響評価

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of stratum corneum barrier and genes for stratification of pediatric atopic dermatitis patients

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Assessment of fetal nutritional environmentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Epigenetic changes in neonates born to Japanese mothers with gestational diabetes

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The effects of in-uterine environment on infant health other than birth weightPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Research for the effects of fetal nutritional environment on epigenetic regulationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification of diet contents regulating RNA methylation and those effects on fetal growthPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The mechanism of aberrant gene expressions in adulthood caused by fetal and neonatal nutrition status.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

インスリン受容体基質が膵β細胞増殖に果たす役割の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

VEGFmRNAに内在された新たな大腸がん進展機構

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of function of tra2 beta alternative splicing mRNA isoformPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Tra2bトランスレーションバリアントによる胃粘膜細胞ストレス応答の分子機構Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] ヒューマンインターフェースのための計測と制御、第4章ストレス応答の分子機構2009

Author(s)

Total Pages

KAWAI Tomoko 河合智子

TOMOKO Kawai 河合智子