Horimoto Yoshiya 堀本義哉

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HORIMOTO Yoshiya 堀本義哉

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Researcher Number	40424246
Other IDs
Affiliation (Current)	2025: 東京医科大学, 医学部, 准教授 2025: 順天堂大学, 医学部, 客員准教授
Affiliation (based on the past Project Information) *help	2023: 順天堂大学, 医学部, 客員准教授 2013 – 2023: 順天堂大学, 医学部, 准教授 2015: 順天堂大学, 医学部, 講師 2013 – 2015: 順天堂大学, 医学部, 助教 2012: 順天堂大学, 医学研究科, 助教
Review Section/Research Field	Principal Investigator Basic Section 55010:General surgery and pediatric surgery-related / General surgery Except Principal Investigator General surgery / Basic Section 53020:Cardiology-related / Basic Section 55010:General surgery and pediatric surgery-related / Basic Section 50020:Tumor diagnostics and therapeutics-related / Basic Section 43030:Functional biochemistry-related / Basic Section 90140:Medical technology assessment-related / Laboratory medicine / Tumor biology / Radiation science / Tumor biology
Keywords	Principal Investigator HER2 / 転移 / 上皮間葉移行 / 浸潤 / 非浸潤性乳癌 / 内分泌療法 / 腫瘍免疫 / 免疫モニタリング / 乳癌 Except Principal Investigator 乳癌 … More / 薬剤耐性 / 上皮間葉移行 / 癌内線維芽細胞 / 転移 / ＣＡＦｓ / CAFｓ / 癌転移 / 癌微小環境 / 乳がん / 心不全 / 化学療法関連心機能障害 / がん治療関連心機能障害 / トラスツズマブ / アンスラサイクリン / 腫瘍循環器学 / Monoclonal antibody / Targeted Treatment / LAR type / Basal 2 type / Triple negative / lectin / chemotherapy / carbohydrate / glycoprotein / Breast cancer / トリプルネガティブ乳がん / TNBC / NGLY1 / 臨床病理学的評価 / ゲノム情報 / 遺伝子発現解析 / ゲノム解析 / 遺伝子解析 / 遺伝カウンセリング / 疾患レジストリー / 遺伝性乳癌 / 稀少がん / 男性乳がん / レジストリー / 希少癌 / BRCA1/2 / VUS / 遺伝性乳癌卵巣がん症候群 / 男性乳癌 / 薬物治療抵抗性 / ＥＲ：ＨＥＲ２ / 薬物療法抵抗性 / ＥＲ陽性ＨＥＲ陽性 / ERシグナル亢進 / ハーセプチン耐性 / クロストーク / ER陽性HER2陽性乳癌 / 血中循環癌細胞 / リンパ球 / トリプルネガティブ乳癌 / 腫瘍浸潤リンパ球 / 乳腺髄様癌 / PDX model / 高度免疫不全マウス / ＰＤＸモデル / 患者乳癌 / PDXｓ / 放射線治療 / 細胞浸潤能 / 細胞遊走能 / 生物学的効果比 / 放射線感受性 / 重粒子線治療 / 炭素イオン線 / 浸潤・転移 / 癌浸潤・転移 / 細胞接着 Less

Role of CD44 bearing TJA-II binding glycans in therapy-resistant subset of triple negative breast cancer
- Principal Investigator
  
  入村達郎
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Juntendo University
トリプルネガティブ乳癌に対する新規治療抗体の樹立
- Principal Investigator
  
  水谷奈津子
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  Kyorin University
心筋ストレインと新規バイオマーカーによるがん治療関連心機能障害の予防と早期診断
- Principal Investigator
  
  宮崎彩記子
- Project Period (FY)
  2022 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Juntendo University
The importance of NGLY1 on the chemoresistance of triple negative breast cancer
- Principal Investigator
  
  Fujihira Haruhiko
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43030:Functional biochemistry-related
- Research Institution
  Institute of Physical and Chemical Research
Database development of male breast cancer in Japan
- Principal Investigator
  
  SAITO MITSUE
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 90140:Medical technology assessment-related
- Research Institution
  Juntendo University
Elucidation of the mrchanism of invasion in ductal carcinoma in situPrincipal Investigator
- Principal Investigator
  
  Horimoto Yoshiya
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  Juntendo University
Isolation and functional analysis of blood circulating breast cancer cells by improved telome scan
- Principal Investigator
  
  Shimizu Hideo
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  Juntendo University
To clarify the role of tumor infiltrate lymphocytes in mammary medullary carcinoma
- Principal Investigator
  
  ARAKAWA Atsushi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Juntendo University
Prediction of therapeutic effect by immunomonitoring during breast cancer treatmentPrincipal Investigator
- Principal Investigator
  
  Horimoto Yoshiya
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  Juntendo University
Elucidation of the interaction between crosstalk between ER and HER2 and drug resistance mechanism in breast cancer
- Principal Investigator
  
  TOKUDA Emi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General surgery
- Research Institution
  Juntendo University
Basic Research for Carbon-Ion Radiotherapy for Breast Cancer
- Principal Investigator
  
  Karasawa Kumiko
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  Tokyo Women's Medical University
  National Institute of Radiological Sciences
Establishment of breast PDX mouse models with high metastatic potential
- Principal Investigator
  
  orimo akira
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Tumor biology
- Research Institution
  Juntendo University
Dissecting molecular mechanisms mediating human breast cancer metastasis
- Principal Investigator
  
  orimo akira
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Tumor biology
- Research Institution
  Juntendo University

All 2024 2022 2021 2019 2017 2015 2014 2013 2012 Other

All Journal Article Presentation

[Journal Article] Glycosylation profiles of breast cancer cells may represent clonal variations of multiple organ metastases2024
- Author(s)
  Horimoto Yoshiya、Hlaing May Thinzar、Saeki Harumi、Denda-Nagai Kaori、Ishii-Schrade Katrin、Fujihira Haruhiko、Abe Masaaki、Noji Miki、Shichino Shigeyuki、Saito Mitsue、Irimura Tatsuro
- Journal Title
  
  Clinical & Experimental Metastasis
  
  Volume: 41 Issue: 3 Pages: 267-270
- DOI
  10.1007/s10585-023-10253-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07163, KAKENHI-PROJECT-23K06241, KAKENHI-PROJECT-21K06092, KAKENHI-PLANNED-22H05064
[Journal Article] Glycans unique to the relapse-prone subset within triple-negative breast cancer as revealed by lectin array-based analysis of surgical specimens2021
- Author(s)
  Sakata-Matsuzawa Madoka、Denda-Nagai Kaori、Fujihira Haruhiko、Noji Miki、Ishii-Schrade Katrin Beate、Matsuda Atsushi、Kuno Atsushi、Okazaki Misato、Nakai Katsuya、Horimoto Yoshiya、Saito Mitsue、Irimura Tatsuro
- Journal Title
  
  PLOS ONE
  
  Volume: 16 Issue: 5 Pages: e0250747-e0250747
- DOI
  10.1371/journal.pone.0250747
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07163, KAKENHI-PROJECT-21K06092
[Journal Article] Estrogen receptor-positive ductal carcinoma in situ frequently overexpresses HER2 protein without gene amplification.2019
- Author(s)
  Horimoto Y, Terao T, Tsutsumi Y, Tanabe M, Mogushi K, Hlaing MT, Sasaki R, Saeki H, Okazaki M, Sonoue H, Arakawa A, Saito M.
- Journal Title
  
  Am J Surg Pathol
  
  Volume: 43(9) Issue: 9 Pages: 1221-1228
- DOI
  10.1097/pas.0000000000001300
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10652, KAKENHI-PROJECT-18K06198, KAKENHI-PROJECT-18K08798, KAKENHI-PROJECT-18K16287
[Journal Article] 乳癌の炭素イオン線感受性に関する研究2015
- Author(s)
  唐澤久美子、藤田真由美、荘司好美、堀本義哉、今井高志
- Journal Title
  
  平成28年度HIMAC共同研究利用研究報告書
  
  Volume: １ Pages: 1-2
- Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25461935
[Journal Article] 乳癌における上皮間葉転換 -治療標的としての臨床応用の可能性-2015
- Author(s)
  猪狩史江、堀本義哉、吉田悠子、徳田恵美、清水秀穂、田辺真彦、齊藤光江
- Journal Title
  
  乳癌の臨床
  
  Volume: 30 Pages: 229-236
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K10069
[Journal Article] Ki67 expression and the effect of neo-adjuvant chemotherapy on luminal HER2-negative breast cancer.2014
- Author(s)
  Horimoto Y1, Arakawa A, Tanabe M, Sonoue H, Igari F, Senuma K, Tokuda E, Shimizu H, Kosaka T, Saito M.
- Journal Title
  
  BMC cancer
  
  Volume: 550 Issue: 1
- DOI
  10.1186/1471-2407-14-550
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26861055
[Journal Article] Biological effectiveness of carbon-ion radiation on various human breast cancer cell lines.2014
- Author(s)
  Karasawa K, Fujita M, Shoji Y, Horimoto Y, Inoue T, Imai T
- Journal Title
  
  Journal of Cell Science & Therapy
  
  Volume: 5（5） Issue: 05 Pages: 1-5
- DOI
  10.4172/2157-7013.1000180
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25461935
[Journal Article] Carcinoma-associated fibroblasts (CAFs) are a promising therapeutic target.2013
- Author(s)
  Togo, S.*, Polanska, Y., Horimoto, Y and Orimo, A
- Journal Title
  
  Cancers,
  
  Volume: 5, Pages: 149-169
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25640069
[Journal Article] Carcinoma-associated fibroblasts (CAFs) are a promising therapeutic target.2013
- Author(s)
  Togo, S.*, Polanska, Y., Horimoto, Y and Orimo, A
- Journal Title
  
  Cancers
  
  Volume: 5 Pages: 149-169
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24300332
[Journal Article] Emerging roles of the tumour-associated stroma in promoting tumour metastasis.,2012
- Author(s)
  Horimoto, Y., Takahashi, T., Polanska, Y. and Orimo, A.
- Journal Title
  
  Cell adhesion and migration,
  
  Volume: 6 Pages: 193-202
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24300332
[Presentation] トリプルネガティブ乳がんの薬剤耐性とNGLY1の関連性2022
- Author(s)
  藤平陽彦、堀本義哉、鈴木匡
- Organizer
  第95回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-21K06092
[Presentation] トリプルネガティブ乳がんにおけるNGLY1の役割2021
- Author(s)
  藤平陽彦、堀本義哉、鈴木匡
- Organizer
  第94回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-21K06092
[Presentation] トリプルネガティブ乳がんにおけるNGLY1の役割2021
- Author(s)
  藤平陽彦、堀本義哉、鈴木匡
- Organizer
  第40回日本糖質学会年会
- Data Source
  KAKENHI-PROJECT-21K06092
[Presentation] 当院における男性乳癌レジストリー構築2021
- Author(s)
  齊藤光江、堀本義哉
- Organizer
  日本臨床外科学会
- Data Source
  KAKENHI-PROJECT-19K12869
[Presentation] Circulating tumour cell analysis to predict efficacy of Eribulin for metastatic breast cancer patients2017
- Author(s)
  Yoshiya Horimoto
- Organizer
  The International Consensus Conference for Advanced Breast Cancer
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10069
[Presentation] Biological effectiveness of carbon-ion radiation on various human breast cancer cell lines, 15th International Congress of Radiation Research2015
- Author(s)
  Karasawa K, Fujita M, Yoshimi S, Horimoto Y, Imai T
- Organizer
  15th International Congress of Radiation Research
- Place of Presentation
  京都国際会館　京都市左京区
- Year and Date
  2015-05-26
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461935
[Presentation] 乳癌の化学療法効果におけるエストロゲンレセプター蛋白の発現と活性による評価の検討2015
- Author(s)
  徳田恵美，清水秀穂，堀本義哉，田辺真彦，三浦佳代，齊籐光江，林　慎一，山口ゆり
- Organizer
  第16回ホルモンと癌研究会
- Place of Presentation
  岐阜　朝日大学村上記念病院
- Year and Date
  2015-07-10
- Data Source
  KAKENHI-PROJECT-26861055
[Presentation] Carcinoma-associated fibroblasts confer metastatic abilities into apposed human mammary carcinoma cells2013
- Author(s)
  Akira Orimo, Yasuhiko Ito, Urszula M Polanska, Kazuyoshi Takeda, Ko Okumura, Okio Hino and Yoshiya Horimoto.
- Organizer
  第7２回日本癌学会学術総会
- Place of Presentation
  横浜
- Invited
- Data Source
  KAKENHI-PROJECT-25640069
[Presentation] A Study of Carbon-ion Radiosensitivity
- Author(s)
  Karasaawa K, Fujita M, Shoji Y, Horimoto Y, Inoue T, Imai T
- Organizer
  第73回日本医学放射線学会総会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-04-10 – 2014-04-13
- Data Source
  KAKENHI-PROJECT-25461935
[Presentation] Triple positive乳癌におけるERとHER2の発現分布についての検討
- Author(s)
  魚森　俊喬、堀本　義哉、齊藤　光江、中井　克也、清水　秀穂、田辺　真彦、徳田　恵美、毛利かの子、荒川　敦
- Organizer
  第２２回日本乳癌学会　学術総会
- Place of Presentation
  大阪国際会議場
- Year and Date
  2014-07-10 – 2014-07-12
- Data Source
  KAKENHI-PROJECT-26861055
[Presentation] 乳癌の化学療法効果予測におけるエストロゲンレセプター発現の意義の検討
- Author(s)
  徳田　恵美、高橋　由佳、堀本　義哉、清水　秀穂、田辺　真彦、中井　克也、齊藤　光江、清野　祐子、山口　ゆり、林　慎一
- Organizer
  第２２回日本乳癌学会　学術総会
- Place of Presentation
  大阪国際会議場
- Year and Date
  2014-07-10 – 2014-07-12
- Data Source
  KAKENHI-PROJECT-26861055

1. SAITO Mitsue (30205679)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. orimo akira (70275866)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
3. TOKUDA Emi (70621960)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
4. ARAKAWA Atsushi (70245695)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
5. 北野滋久 (60402682)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. Karasawa Kumiko (60214574)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
7. IMAI Takashi (50183009)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
8. FUJITA Mayumi (80580331)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
9. Shimizu Hideo (50424247)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
10. Fujihira Haruhiko (50721057)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
11. 小坂泰二郎 (40398681)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 十合晋作 (80365634)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 小見山博光 (30348982)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 江口英孝 (00260232)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 新井正美 (20232027)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 入村達郎 (80092146)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 伝田香里 (00313122)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 水谷奈津子 (10850076)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 松岡周二 (20286743)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 宮崎彩記子 (60407319)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 荻田学 (10794133)

# of Collaborated Projects: 1 results

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22. 鍵山暢之 (20722010)

# of Collaborated Projects: 1 results

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23. 宮崎哲朗 (30600473)

# of Collaborated Projects: 1 results

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24. 尾関理恵 (60801991)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. MOGUSHI Kaoru

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
26. 傅田香里

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Horimoto Yoshiya 堀本 義哉

HORIMOTO Yoshiya 堀本 義哉

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Elucidation of the mrchanism of invasion in ductal carcinoma in situPrincipal Investigator

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Prediction of therapeutic effect by immunomonitoring during breast cancer treatmentPrincipal Investigator

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[Journal Article] Glycosylation profiles of breast cancer cells may represent clonal variations of multiple organ metastases2024

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[Journal Article] Glycans unique to the relapse-prone subset within triple-negative breast cancer as revealed by lectin array-based analysis of surgical specimens2021

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Horimoto Yoshiya 堀本義哉

HORIMOTO Yoshiya 堀本義哉