TOYOMURA Takao 豊村隆男

Researcher Number	40425137
Other IDs
Affiliation (Current)	2025: 就実大学, 薬学部, 准教授
Affiliation (based on the past Project Information) *help	2022 – 2024: 就実大学, 薬学部, 准教授 2015 – 2021: 就実大学, 薬学部, 講師 2013 – 2014: 就実大学, 薬学部, 助教
Review Section/Research Field	Except Principal Investigator Basic Section 47060:Clinical pharmacy-related / Applied pharmacology
Keywords	Except Principal Investigator 炎症 / サイトカイン / 組織リモデリング / 相互作用 / DAMPs / ダメージ関連分子パターン / AGEs / 終末糖化産物 / HMGB1 / 分子標的 … More / リボソームタンパク質 / LPS / 自然免疫 / 医療薬学 / 慢性炎症 / 再生 Less

炎症性疾患の新規治療標的としてのDAMPsインタラクトームの解明
- Principal Investigator
  
  渡邊政博
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Shujitsu University
内因性ＡＧＥをコアとする組織リモデリング病態の増悪化機序解明と根治的治療法の開発
- Principal Investigator
  
  森秀治
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Shujitsu University
Elucidation of the mechanism of tissue remodeling exacerbated by endogenous AGEs and the development of novel targeted therapy
- Principal Investigator
  
  MORI Shuji
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Shujitsu University
Identification of inflammation suppressive DAMPs and their pathophysiological significance in inflammatory diseases
- Principal Investigator
  
  WATANABE Masahiro
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Shujitsu University
Study of the pathophysiological significance of endogenous AGE as an exacerbating factor for tissue remodeling, and the development of novel targeted therapy
- Principal Investigator
  
  MORI Shuji
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Shujitsu University
Roles of AGEs as exacerbation factor in pathogenesis of tissue remodeling and the development of novel targeted therapy
- Principal Investigator
  
  MORI Shuji
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied pharmacology
- Research Institution
  Shujitsu University
Elucidating the molecular bases and pathophysiological significances of the extracellular inflammasome which drives chronic inflammation
- Principal Investigator
  
  Watanabe Masahiro
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Applied pharmacology
- Research Institution
  Shujitsu University
Pathophysiological role of AGEs as exacerbation factor in tissue remodeling and molecular targeted therapy
- Principal Investigator
  
  MORI Shuji
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied pharmacology
- Research Institution
  Shujitsu University

All 2023 2022 2021 2017 2016 2015 2014 Other

All Journal Article Presentation

[Journal Article] Cationic ribosomal proteins can inhibit pro‐inflammatory action stimulated by LPS+HMGB1 and are hindered by advanced glycation end products2023
- Author(s)
  Watanabe Masahiro、Toyomura Takao、Wake Hidenori、Nishinaka Takashi、Hatipoglu Omer Faruk、Takahashi Hideo、Nishibori Masahiro、Mori Shuji
- Journal Title
  
  Biotechnology and Applied Biochemistry
  
  Volume: 71 Issue: 2 Pages: 264-271
- DOI
  10.1002/bab.2538
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K06588, KAKENHI-PROJECT-21K06657, KAKENHI-PROJECT-21K06701, KAKENHI-PROJECT-21K15354
[Journal Article] Glycolaldehyde-derived advanced glycation end products promote macrophage proliferation via the JAK-STAT signaling pathway2023
- Author(s)
  Toyomura Takao、Watanabe Masahiro、Wake Hidenori、Nishinaka Takashi、Hatipoglu Omer Faruk、Takahashi Hideo、Nishibori Masahiro、Mori Shuji
- Journal Title
  
  Molecular Biology Reports
  
  Volume: 50 Issue: 7 Pages: 5849-5858
- DOI
  10.1007/s11033-023-08509-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K10465, KAKENHI-PROJECT-21K06588, KAKENHI-PROJECT-21K06657, KAKENHI-PROJECT-21K06701
[Journal Article] Nordihydroguaiaretic acid inhibits glyoxalase I, and causes the accumulation of methylglyoxal followed by cell-growth inhibition2022
- Author(s)
  Watanabe Masahiro、Toyomura Takao、Ikegami Ryo、Suwaki Yui、Sada Minami、Wake Hidenori、Nishinaka Takashi、Hatipoglu Omer Faruk、Takahashi Hideo、Nishibori Masahiro、Mori Shuji
- Journal Title
  
  Molecular Biology Reports
  
  Volume: 49 Issue: 11 Pages: 10499-10507
- DOI
  10.1007/s11033-022-07929-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06588, KAKENHI-PROJECT-21K06701, KAKENHI-PROJECT-21K15354
[Journal Article] Identification of ribosomal protein L9 as a novel regulator of proinflammatory damage-associated molecular pattern molecules2022
- Author(s)
  Watanabe Masahiro、Toyomura Takao、Wake Hidenori、Nishinaka Takashi、Hatipoglu Omer Faruk、Takahashi Hideo、Nishibori Masahiro、Mori Shuji
- Journal Title
  
  Molecular Biology Reports
  
  Volume: 49 Issue: 4 Pages: 2831-2838
- DOI
  10.1007/s11033-021-07096-0
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06588, KAKENHI-PROJECT-21K06701, KAKENHI-PROJECT-21K15354
[Journal Article] Advanced glycation end products attenuate the function of tumor necrosis factor-like weak inducer of apoptosis to regulate the inflammatory response2017
- Author(s)
  Watanabe M, Toyomura T, Wake H, Liu K, Teshigawara K, Takahashi H, Nishibori M, Mori S
- Journal Title
  
  Molecular and Cellular Biochemistry
  
  Volume: 印刷中 Issue: 1-2 Pages: 153-162
- DOI
  10.1007/s11010-017-3045-6
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15H06785, KAKENHI-PROJECT-15K08605, KAKENHI-PROJECT-16K08232, KAKENHI-PROJECT-16K08909, KAKENHI-PROJECT-15K08253
[Presentation] 終末糖化産物AGEs共存化でのサイトカインによるTNF-a分泌の誘導効果2023
- Author(s)
  豊村隆男　他
- Organizer
  第96回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-21K06657
[Presentation] 抑制性DAMPsとしてのリボソーム構成分子RPL9の同定2022
- Author(s)
  渡邊政博，豊村隆男，和氣秀徳，西中崇，ハティポールオメルファルク，高橋英夫，西堀正洋，森　秀治
- Organizer
  第141回日本薬理学会近畿部会
- Data Source
  KAKENHI-PROJECT-21K06701
[Presentation] 新規AGEs結合分子AGE-BP2がDAMPsの作用に与える影響の解析2021
- Author(s)
  渡邊政博，豊村隆男，和氣秀徳，西中崇，逢坂大樹，王登莉，高橋英夫，西堀正洋，森秀治
- Organizer
  第139回日本薬理学会近畿部会
- Data Source
  KAKENHI-PROJECT-21K06701
[Presentation] 破骨細胞分化抑制因子としてのSHIL004の機能解析2017
- Author(s)
  豊村隆男　他
- Organizer
  ConBio2017（第90回日本分子生物学会，第90回日本生化学会合同大会）
- Data Source
  KAKENHI-PROJECT-15K08605
[Presentation] AGEs 共存による Damps 関連サイトカイン類の機能変化2016
- Author(s)
  渡邊政博，豊村隆男，和氣秀徳，劉克約，勅使川原匡，高橋英夫，西堀正洋，森秀治
- Organizer
  日本薬学会第136年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-15H06785
[Presentation] AGEsとTNF関連サイトカインとの相互作用部位の解析2016
- Author(s)
  渡邊政博，豊村隆男，和氣秀徳，劉克約，勅使川原匡，高橋英夫，西堀正洋，森秀治
- Organizer
  第26回創薬・薬理フォーラム
- Place of Presentation
  岡山大学医学部（岡山県岡山市）
- Data Source
  KAKENHI-PROJECT-15H06785
[Presentation] Damps関連サイトカインの機能に対するAGEsの影響2016
- Author(s)
  渡邊政博，豊村隆男，和氣秀徳，劉克約，勅使川原匡，高橋英夫，西堀正洋，森秀治
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台国際センター／東北大学川内北キャンパス（宮城県仙台市）
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-15H06785
[Presentation] 非炎症分子SHILsはサイトカインとともに破骨細胞分化を調節する2016
- Author(s)
  豊村隆男　他
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（横浜市）
- Year and Date
  2016-12-02
- Data Source
  KAKENHI-PROJECT-15K08605
[Presentation] 破骨細胞分化ステージ特異的な非炎症性物質SHIL001及びSHIL002の効果2015
- Author(s)
  豊村隆男
- Organizer
  第38回日本分子生物学会・第88回日本生化学会合同大会
- Place of Presentation
  神戸国際会議場（神戸市）
- Year and Date
  2015-12-02
- Data Source
  KAKENHI-PROJECT-15K08605
[Presentation] HMGB1と相互作用するサイトカインに対するAGEsの影響2015
- Author(s)
  渡邊政博，豊村隆男，和氣秀徳，劉克約，勅使川原匡，高橋英夫，西堀正洋，森秀治
- Organizer
  BMB2015 第38回日本分子生物学会，第88回日本生化学会合同大会
- Place of Presentation
  神戸ポートアイランド（神戸ポートピアホテル，神戸国際会議場，神戸国際展示場，神戸商工会議所）（兵庫県神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15H06785
[Presentation] HMGB1結合因子によるAGEs-RAGE結合阻害解析2014
- Author(s)
  森　秀治，和氣秀徳，劉克約，勅使川原匡，高橋英夫，西堀正洋，豊村隆男
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  国立京都国際会館（京都）
- Year and Date
  2014-10-16
- Data Source
  KAKENHI-PROJECT-24590672
[Presentation] HMGB1結合因子の網羅的アレイ探索と機能調節2014
- Author(s)
  森　秀治，和氣秀徳，劉克約，勅使川原匡，高橋英夫，西堀正洋，豊村隆男
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（横浜）
- Year and Date
  2014-11-25
- Data Source
  KAKENHI-PROJECT-24590672
[Presentation] AGEs結合親和性に基づいたAGEs遮断ペプチドの同定2014
- Author(s)
  横山隆太，豊村隆男，和氣秀徳，勅使川原匡，劉克約，高橋英夫，西堀正洋，森　秀治
- Organizer
  第125回日本薬理学会近畿部会
- Place of Presentation
  岡山コンベンションセンター（岡山）
- Year and Date
  2014-06-20
- Data Source
  KAKENHI-PROJECT-24590672
[Presentation] 非炎症性物質の長期曝露に伴うマクロファージの炎症応答変化
- Author(s)
  豊村隆男
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡国際会議場（福岡市）
- Data Source
  KAKENHI-PROJECT-24590672

1. MORI Shuji (50220009)

# of Collaborated Projects: 8 results

# of Collaborated Products: 10 results
2. Watanabe Masahiro (10758246)

# of Collaborated Projects: 7 results

# of Collaborated Products: 7 results
3. GOMITA Yutaka (00088709)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. WAKE Hidenori

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
5. 高橋英夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
6. 西中崇

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
7. ハティポールオメル・ファルク

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results

TOYOMURA Takao 豊村 隆男

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[Journal Article] Cationic ribosomal proteins can inhibit pro‐inflammatory action stimulated by LPS+HMGB1 and are hindered by advanced glycation end products2023

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[Journal Article] Glycolaldehyde-derived advanced glycation end products promote macrophage proliferation via the JAK-STAT signaling pathway2023

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[Journal Article] Nordihydroguaiaretic acid inhibits glyoxalase I, and causes the accumulation of methylglyoxal followed by cell-growth inhibition2022

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[Journal Article] Identification of ribosomal protein L9 as a novel regulator of proinflammatory damage-associated molecular pattern molecules2022

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[Journal Article] Advanced glycation end products attenuate the function of tumor necrosis factor-like weak inducer of apoptosis to regulate the inflammatory response2017

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[Presentation] 終末糖化産物AGEs共存化でのサイトカインによるTNF-a分泌の誘導効果2023

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[Presentation] 抑制性DAMPsとしてのリボソーム構成分子RPL9の同定2022

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[Presentation] 新規AGEs結合分子AGE-BP2がDAMPsの作用に与える影響の解析2021

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TOYOMURA Takao 豊村隆男