Mori Tsuyoshi 森剛志

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MORI Tsuyoshi 森剛志

森剛志モリツヨシ

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Researcher Number	40426565
Other IDs
Affiliation (Current)	2025: 宮崎大学, 医学部, 助教
Affiliation (based on the past Project Information) *help	2016 – 2023: 宮崎大学, 医学部, 助教 2014 – 2016: 長崎大学, 医歯薬学総合研究科(医学系), 助教 2012: 徳島大学, 疾患酵素学研究センター, 助教
Review Section/Research Field	Principal Investigator Infectious disease medicine / Basic Section 52020:Neurology-related / Basic Section 52010:General internal medicine-related / Neurology Except Principal Investigator Neurology
Keywords	Principal Investigator QUIC法 / 孤発性CJD / プリオン病 / プリオン高感度検出法 / プリオン検出法 / クロイツフェルト・ヤコブ病 / パネルRT-QUIC法 Except Principal Investigator クロイツフェルト・ヤコプ病(CJD) / 髄液 / ゲルストマン・ストロイスラー・シャインカー病 … More / クロイツフェルト・ヤコブ病 / 髄液検査 / 臨床症状 / 診断法 / プリオン病 Less

脳・脊髄液以外の検体からの微量異常型プリオン蛋白検出法の開発Principal Investigator
- Principal Investigator
  
  森剛志
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  University of Miyazaki
Development of an early diagnosis of Creutzfeldt-Jakob disease using easily collected specimensPrincipal Investigator
- Principal Investigator
  
  MORI Tsuyoshi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  University of Miyazaki
Establishment of a method for diagnosing subtypes of Creutzfeldt-Jakob diseasePrincipal Investigator
- Principal Investigator
  
  MORI Tsuyoshi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Infectious disease medicine
- Research Institution
  University of Miyazaki
Establishments of diagnosis for patients' CSF in humanprion disease and novel prion clinical research through field work
- Principal Investigator
  
  SATOH Katsuya
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurology
- Research Institution
  Nagasaki University
Development of useful method in differential diagnosis of Creutzfeldt-Jakob diseasesPrincipal Investigator
- Principal Investigator
  
  MORI Tsuyoshi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Infectious disease medicine
- Research Institution
  University of Miyazaki
  Nagasaki University
プリオン蛋白過剰発現が誘導するオートファジーのメカニズム解明Principal Investigator
- Principal Investigator
  
  森剛志
- Project Period (FY)
  2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurology
- Research Institution
  The University of Tokushima

All 2022 2021 2020 2019 2018 2017 2016 2015

All Journal Article Presentation

[Journal Article] Pentosan polysulfate induces low-level persistent prion infection keeping measurable seeding activity without PrP-res detection in Fukuoka-1 infected cell cultures2022
- Author(s)
  Takatsuki H, Imamura M, Mori T, Atarashi R.
- Journal Title
  
  Sci Rep.
  
  Volume: － Issue: 1 Pages: 7923-7923
- DOI
  10.1038/s41598-022-12049-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02721, KAKENHI-PROJECT-21K05938, KAKENHI-PROJECT-21K07277, KAKENHI-PROJECT-20K07807
[Journal Article] Spontaneous generation of distinct prion variants with recombinant prion protein from a baculovirus-insect cell expression system2022
- Author(s)
  Imamura M, Tabeta N, Iwamaru Y, Takatsuki H, Mori T, Atarashi R.
- Journal Title
  
  Biochem Biophys Res Commun .
  
  Volume: 613 Pages: 67-72
- DOI
  10.1016/j.bbrc.2022.04.137
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02721, KAKENHI-PROJECT-21K05938, KAKENHI-PROJECT-20K07807
[Journal Article] Ethanolamine Is a New Anti-Prion Compound2021
- Author(s)
  Uchiyama Keiji、Hara Hideyuki、Chida Junji、Pasiana Agriani Dini、Imamura Morikazu、Mori Tsuyoshi、Takatsuki Hanae、Atarashi Ryuichiro、Sakaguchi Suehiro
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 22 Issue: 21 Pages: 11742-11742
- DOI
  10.3390/ijms222111742
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08930, KAKENHI-PROJECT-19H03548, KAKENHI-PROJECT-20K07807, KAKENHI-PROJECT-21K07462
[Journal Article] Discrimination between L-type and C-type bovine spongiform encephalopathy by the strain-specific reactions of real-time quaking-induced conversion2020
- Author(s)
  Ubagai Kaori、Fukuda Shigeo、Mori Tsuyoshi、Takatsuki Hanae、Taguchi Yuzuru、Kageyama Soichi、Nishida Noriyuki、Atarashi Ryuichiro
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 526 Issue: 4 Pages: 1049-1053
- DOI
  10.1016/j.bbrc.2020.03.183
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10022, KAKENHI-PROJECT-20K07807, KAKENHI-PROJECT-19K22600
[Journal Article] Administration of FK506 from Late Stage of Disease Prolongs Survival of Human Prion-Inoculated Mice2020
- Author(s)
  Takehiro Nakagaki, Daisuke Ishibashi, Tsuyoshi Mori, Yukiko Miyazaki, Hanae Takatsuki, Hiroya Tange, Yuzuru Taguchi, Katsuya Satoh, Ryuichiro Atarashi, Noriyuki Nishida
- Journal Title
  
  Neurotherapeutics
  
  Volume: 17(4) Issue: 4 Pages: 1850-1860
- DOI
  10.1007/s13311-020-00870-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07844, KAKENHI-PROJECT-20K07807, KAKENHI-PROJECT-19K22600, KAKENHI-PROJECT-17K09759, KAKENHI-PROJECT-20H04285
[Journal Article] Type I interferon protects neurons from prions in in vivo models2019
- Author(s)
  Ishibashi Daisuke、Homma Takujiro、Nakagaki Takehiro、Fuse Takayuki、Sano Kazunori、Satoh Katsuya、Mori Tsuyoshi、Atarashi Ryuichiro、Nishida Noriyuki
- Journal Title
  
  Brain
  
  Volume: 142 Issue: 4 Pages: 1035-1050
- DOI
  10.1093/brain/awz016
- NAID
  120006987735
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10022, KAKENHI-PROJECT-17K09759, KAKENHI-PROJECT-19K07844, KAKENHI-PROJECT-17K16126
[Journal Article] Age of donor of human mesenchymal stem cells affects structural and functional recovery after cell therapy following ischaemic stroke2017
- Author(s)
  Yamaguchi Susumu、Horie Nobutaka、Satoh Katsuya、Ishikawa Takeshi、Mori Tsuyoshi、Maeda Hajime、Fukuda Yuhtaka、Ishizaka Shunsuke、Hiu Takeshi、Morofuji Yoichi、Izumo Tsuyoshi、Nishida Noriyuki、Matsuo Takayuki
- Journal Title
  
  Journal of Cerebral Blood Flow & Metabolism
  
  Volume: 印刷中 Issue: 7 Pages: 1199-1212
- DOI
  10.1177/0271678x17731964
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K00397, KAKENHI-PROJECT-17K10022, KAKENHI-PROJECT-17K10840, KAKENHI-PROJECT-15KK0349, KAKENHI-PROJECT-16H05840
[Journal Article] A direct assessment of human prion adhered to steel wire using real-time quaking-induced conversion.2016
- Author(s)
  Mori T, Atarashi R, Furukawa K, Takatsuki H, Satoh K, Sano K, Nakagaki T, Ishibashi D, Ichimiya K, Hamada M, Nakayama T, Nishida N.
- Journal Title
  
  Sci Rep.
  
  Volume: 6 Issue: 1 Pages: 24993-24993
- DOI
  10.1038/srep24993
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H04269, KAKENHI-PROJECT-26305030, KAKENHI-PROJECT-26461507, KAKENHI-PROJECT-16K07042
[Journal Article] Sequential Washing with Electrolyzed Alkaline and Acidic Water Effectively Removes Pathogens from Metal Surfaces.2016
- Author(s)
  Nakano Y, Akamatsu N, Mori T, Sano K, Satoh K, Nagayasu T, Miyoshi Y, Sugio T, Sakai H, Sakae E, Ichimiya K, Hamada M, Nakayama T, Fujita Y, Yanagihara K, Nishida N. Sequential
- Journal Title
  
  PLoS One
  
  Volume: 11(5) Issue: 5 Pages: e0156058-e0156058
- DOI
  10.1371/journal.pone.0156058
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26305030, KAKENHI-PROJECT-26461507
[Journal Article] Prion-Seeding Activity Is widely Distributed in Tissues of Sporadic Creutzfeldt-Jakob Disease Patients.2016
- Author(s)
  Takatsuki H, Fuse T, Nakagaki T, Mori T, Mihara B, Takao M, Iwasaki Y, Yoshida M, Murayama S, Atarashi R, Nishida N, Satoh K.
- Journal Title
  
  EBioMedicine.
  
  Volume: 12 Pages: 150-155
- DOI
  10.1016/j.ebiom.2016.08.033
- NAID
  120006987618
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H04269, KAKENHI-PROJECT-26430060, KAKENHI-PROJECT-26461507, KAKENHI-PROJECT-15K08369, KAKENHI-PROJECT-16K18384
[Journal Article] Prion-Seeding Activity Is widely Distributed in Tissues of Sporadic Creutzfeldt-Jakob Disease Patients.2016
- Author(s)
  Takatsuki H, Fuse T, Nakagaki T, Mori T, Mihara B, Takao M, Iwasaki Y, Yoshida M, Murayama S, Atarashi R, Nishida N, Satoh K.
- Journal Title
  
  EBioMedicine
  
  Volume: 12 Pages: 150-155
- NAID
  120006987618
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26305030
[Journal Article] Ubiquitin-specific protease 14 modulates degradation of cellular prion protein.2015
- Author(s)
  Homma T, Ishibashi D, Nakagaki T, Fuse T, Mori T, Satoh K, Atarashi R, Nishida N.
- Journal Title
  
  Sci Rep.
  
  Volume: 5 Issue: 1 Pages: 11028-11028
- DOI
  10.1038/srep11028
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H04269, KAKENHI-PROJECT-26860671, KAKENHI-PROJECT-26305030
[Journal Article] Rapid and Quantitative Assay of Amyloid-Seeding Activity in Human Brains Affected with Prion Diseases.2015
- Author(s)
  Takatsuki H, Satoh K, Sano K, Fuse T, Nakagaki T, Mori T, Ishibashi D, Mihara B, Takao M, Iwasaki Y, Yoshida M, Atarashi R, Nishida N.
- Journal Title
  
  PLoS One
  
  Volume: 10 Issue: 6 Pages: 0126930-0126930
- DOI
  10.1371/journal.pone.0126930
- NAID
  120006986998
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08369, KAKENHI-PROJECT-26430060, KAKENHI-PROJECT-15H04269, KAKENHI-PROJECT-25461514, KAKENHI-PROJECT-26860671, KAKENHI-PROJECT-26305030
[Presentation] ヒトグリオーマ細胞におけるプリオン感染動態の解析2021
- Author(s)
  森剛志、今村守一、髙月英恵、井口洋美、大野美奈子、新竜一郎
- Organizer
  第６８回に本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-20K07807
[Presentation] Isolation of hidden minor prion conformers from classical scrapie isolates in advanced protein misfolding cyclic amplification in the presence of arginine ethyl ester2019
- Author(s)
  Imamura M, Miyazawa K, Matsuura Y, Iwamaru Y, Kitamoto T, Mohri S, Takatsuki H, Mori T, Atarashi R
- Organizer
  APPS2019
- Data Source
  KAKENHI-PROJECT-17K10022
[Presentation] Comparison of RT-QUIC reactions using various recombinant prion protein2019
- Author(s)
  Mori T, Imamura M, Takatsuki H, Iguchi H, Ohno M, Atarashi R
- Organizer
  The 67th Annual Meeting of the Japanese Society for Virology
- Data Source
  KAKENHI-PROJECT-17K10022
[Presentation] Pentosan polysulfate induces latent prion infection in Fukuoka-1 strain-infected cells2019
- Author(s)
  Takatsuki H, Mori T, Imamura M, Atarashi R
- Organizer
  APPS2019
- Data Source
  KAKENHI-PROJECT-17K10022
[Presentation] Simultaneous addition of digitonin, heparin and arginine ethyl ester improves in vitro amplification of PrPSc derived from various prion strains.2018
- Author(s)
  Imamura M, Tabeta N, Matsuura Y, Iwamaru Y, Kitamoto T, Ma J, Mohri S, Murayama Y, Takatsuki H, Mori T, Atarashi R
- Organizer
  APPS2018
- Data Source
  KAKENHI-PROJECT-17K10022
[Presentation] Highly sensitive detection of PrPSc derived from various prion strains by simultaneous addition of digitonin, heparin and arginine ethyl ester to protein misfolding cyclic amplification.2018
- Author(s)
  Imamura M, Tabeta N, Matsuura Y, Iwamaru Y, Kitamoto T, Ma J, Mohri S, Murayama Y, Takatsuki H, Mori T, Atarashi R
- Organizer
  Prion 2018
- Data Source
  KAKENHI-PROJECT-17K10022
[Presentation] Spontaneously-generated baculovirus-derived abnormal recombinant prion protein has infectivity.（自発的生成した異常型バキュロウイルス由来組換えプリオン蛋白質は感染性を有する）2017
- Author(s)
  Imamura M, Tabeta N, Iwamaru Y, Yokoyama T, Murayama Y, Mori T, Takatsuki H, Atarashi R
- Organizer
  第65回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-17K10022
[Presentation] Wire-QuIC reaction can detect abnormal human prion seeds from contaminated stainless steel-wire2016
- Author(s)
  Tsuyoshi Mori, Ryuichiro Atarashi, Katsuya Satoh, Daisuke Ishibashi, Takehiro Nakagaki, Noriyuki Nishida
- Organizer
  The 64th Annual Meeting of the Japanese Society for Virology
- Place of Presentation
  札幌コンベンションセンター
- Year and Date
  2016-10-23
- Data Source
  KAKENHI-PROJECT-26461507
[Presentation] "Wire-QuIC": a new detection system of human prion2016
- Author(s)
  Tsuyoshi Mori, Ryuichiro Atarashi, Hanae Takatsuki, Katsuya Satoh, Takehiro Nakagaki, Daisuke Ishibashi, Noriyuki Nishida
- Organizer
  PRION 2016 TOKYO
- Place of Presentation
  Hitotsubashi Hall, National Center of Sciences Building
- Year and Date
  2016-05-10
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461507
[Presentation] Analysis of biomarkers and RT-QUIC method of CSF in prion disease’ patients2015
- Author(s)
  Katsuya Satoh，Ryuichiro Atarashi，Hanae Takatuki，Tsuyoshi Mori，
- Organizer
  第56回日本神経学会学術大会
- Place of Presentation
  朱鷺メッセ (新潟コンベンションセンター)（新潟県）
- Year and Date
  2015-05-20
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26305030

1. SATOH Katsuya (70398147)

# of Collaborated Projects: 5 results

# of Collaborated Products: 6 results
2. ATARASHI Ryuichiro (90452846)

# of Collaborated Projects: 2 results

# of Collaborated Products: 9 results
3. ISHIKAWA Takeshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. IWAMARU Yoshifumi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. CHIDA Junji

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. ISHIBASHI Ishibashi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 岩崎靖

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Mori Tsuyoshi 森 剛志

MORI Tsuyoshi 森 剛志

森 剛志 モリ ツヨシ

Research Projects

Research Products

Co-Researchers

脳・脊髄液以外の検体からの微量異常型プリオン蛋白検出法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of an early diagnosis of Creutzfeldt-Jakob disease using easily collected specimensPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Establishment of a method for diagnosing subtypes of Creutzfeldt-Jakob diseasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Establishments of diagnosis for patients' CSF in humanprion disease and novel prion clinical research through field work

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of useful method in differential diagnosis of Creutzfeldt-Jakob diseasesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

プリオン蛋白過剰発現が誘導するオートファジーのメカニズム解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Pentosan polysulfate induces low-level persistent prion infection keeping measurable seeding activity without PrP-res detection in Fukuoka-1 infected cell cultures2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Spontaneous generation of distinct prion variants with recombinant prion protein from a baculovirus-insect cell expression system2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Ethanolamine Is a New Anti-Prion Compound2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Discrimination between L-type and C-type bovine spongiform encephalopathy by the strain-specific reactions of real-time quaking-induced conversion2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Administration of FK506 from Late Stage of Disease Prolongs Survival of Human Prion-Inoculated Mice2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Type I interferon protects neurons from prions in in vivo models2019

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Age of donor of human mesenchymal stem cells affects structural and functional recovery after cell therapy following ischaemic stroke2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A direct assessment of human prion adhered to steel wire using real-time quaking-induced conversion.2016

Author(s)

Mori Tsuyoshi 森剛志

MORI Tsuyoshi 森剛志

森剛志モリツヨシ