Higuchi Chikahisa 樋口周久

… Alternative Names

樋口周久ヒグチチカヒサ

HIGUCHI Chikahisa 樋口周久

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Researcher Number	40432421
Affiliation (Current)	2025: 地方独立行政法人大阪府立病院機構大阪母子医療センター(研究所), その他部局等, 整形外科・主任部長
Affiliation (based on the past Project Information) *help	2018 – 2020: 地方独立行政法人大阪府立病院機構大阪母子医療センター(研究所), その他部局等, 整形外科・主任部長 2015: 地方独立行政法人大阪府立病院機構大阪府立母子保健総合医療センター(研究所), その他部局等, その他 2009 – 2014: Osaka University, 保健センター, 助教 2012 – 2013: 大阪大学, 学内共同利用施設等, 助教 2012: 大阪大学, 医学系研究科, 助教
Review Section/Research Field	Principal Investigator Orthopaedic surgery Except Principal Investigator Orthopaedic surgery / Basic Section 56020:Orthopedics-related
Keywords	Principal Investigator MAPK / 炎症シグナル / MEK2 / MEK1 / MEK5 / CRP / Btk / osteoblast / Src kinase / noggin … More / MEK5-Eｒｋ５ / Schwann細胞 / Mek5-Erk5 / Noggin / Schwannoma / 神経組織 / Unc5 / Netrin / 骨芽細胞分化 … More Except Principal Investigator 成長軟骨帯 / 変形矯正 / 成長軟骨帯損傷 / 間葉系幹細胞 / 滑膜由来間葉系幹細胞 / 再生 / 内反変形 / 内反 / Animal Origin Free / 角度変形 / 成長軟骨損傷 / 3次元培養 / 骨性架橋 / ハプログループ / ミトコンドリアDNA / 臼蓋形成不全症 / ミトコンドリアDNAパプログループ / ミトコンドリアDNAハプログループ / 臼蓋形成不全 / 自己由来スキャフォールド / 膝半月板 / 再生治療 / フィブリンクロット / 半月板再生 / 自己由来材料 / 四肢機能再建学 / 早期成長軟骨帯閉鎖 / 3次元間葉系細胞由来組織 / 早期骨端線閉鎖 / 成長軟骨帯再生 / 3次元人工組織 / 間葉系細胞 / 骨橋 / iPS細胞 / 無血清培地 / 骨芽細胞分化 / 悪性骨腫瘍 / 化学療法 / 骨再生医療 Less

Costal cartilage regeneration study using 3D cultured cell transplantation for clinical application
- Principal Investigator
  
  Ostuki Dai
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Osaka University
Investigation of the relationship between bone formation and inflammatory signalingPrincipal Investigator
- Principal Investigator
  
  Higuchi Chikahisa
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Research Institute, Osaka Medical Center for Maternal and Child Health
  Osaka University
Investigation of relationship between hip dysplasia and mitochondrial DNA haplotype
- Principal Investigator
  
  Sugano Nobuhiko
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Osaka University
Optimization of Regeneration Technique for Large Bone Defect
- Principal Investigator
  
  MYOUI Akira
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Osaka University
Regeneration of growth plate using mesenchymal stem cells
- Principal Investigator
  
  YOSHIKAWA Hideki
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Osaka University
Induction of differentiation to musculoskeletal tissue with autologous blood-derived scaffold and application to regenerative medicine
- Principal Investigator
  
  KITA Keisuke
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Osaka University
Investigation of new relations between neural and skeletal tissuesPrincipal Investigator
- Principal Investigator
  
  HIGUCHI Chikahisa
- Project Period (FY)
  2009 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Osaka University

All 2015 2013 2012 2011

All Journal Article Presentation

[Journal Article] Hyaluronan inhibits BMP-induced osteoblast differentiation.2015
- Author(s)
  Kaneko K, Higuchi C, Kunugiza Y, Yoshida K, Sakai T, Yoshikawa H, Nakata K.
- Journal Title
  
  FEBS Lett.
  
  Volume: 589 Issue: 4 Pages: 447-454
- DOI
  10.1016/j.febslet.2014.12.031
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25462369
[Journal Article] MEK5 suppresses osteoblastic differentiation.2015
- Author(s)
  Kaneshiro S, Otsuki D, Yoshida K, Yoshikawa H, Higuchi C.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 463 Issue: 3 Pages: 241-247
- DOI
  10.1016/j.bbrc.2015.05.035
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25462369, KAKENHI-PROJECT-26293336
[Journal Article] Bruton tyrosine kinase (Btk) suppresses osteoblastic differentiation.2015
- Author(s)
  Kaneshiro S, Ebina K, Shi K, Yoshida K, Otsuki D, Yoshikawa H, Higuchi C.
- Journal Title
  
  J Bone Miner Metab.
  
  Volume: 33 Issue: 5 Pages: 486-495
- DOI
  10.1007/s00774-014-0612-8
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25462369, KAKENHI-PROJECT-26861189
[Journal Article] Treatment of partial growth arrest using an in vitro-generated scaffold-free tissue-engineered construct derived from rabbit synovial mesenchymal stem cells2012
- Author(s)
  Yoshida K, Higuchi C, Nakura A, Nakamura N, Yoshikawa H
- Journal Title
  
  J Pediatr Orthop
  
  Volume: 32(3) Issue: 3 Pages: 314-21
- DOI
  10.1097/bpo.0b013e31824afee3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659721
[Journal Article] Hip joint pigmented villonodular synovitis in a young girl : a case report2012
- Author(s)
  Higuchi C, Ohno I, Yoshikawa H
- Journal Title
  
  Journal of Pediatric Orthopaedics B
  
  Volume: 21(4) Issue: 4 Pages: 335-8
- DOI
  10.1097/bpb.0b013e3283524bdf
- ISSN
  1060-152X
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659721
[Presentation] 陳旧性坐骨結節骨折に対して手術加療を施行した1例2013
- Author(s)
  藤本初月、樋口周久、吉田清志、吉川秀樹
- Organizer
  第121回中部日本整形外科災害外科学会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-23659721
[Presentation] Bruton's tyrosine kinase suppresses the osteoblast differentiation2013
- Author(s)
  Shoichi Kaneshiro, Chikahisa Higuchi, Kousuke Ebina, Kenrin Shi, Hideki Yoshikawa
- Organizer
  2nd Joint Meeting of the International Bone and Mineral Society and The Japanese Society for Bone and Mineral Research
- Place of Presentation
  Kobe, Japan
- Data Source
  KAKENHI-PROJECT-25462369
[Presentation] Correction of knee deformity following physeal arrest with the aid of a three-dimensional computer system2013
- Author(s)
  樋口周久、吉田清志、村瀬剛、吉川秀樹
- Organizer
  9^<th> Asia Pacific Orthopaedic Association Paediatric Section
- Place of Presentation
  クチン・マレーシア
- Data Source
  KAKENHI-PROJECT-23659721
[Presentation] 間葉系幹細胞由来三次元人工組織（TEC)による成長軟骨修復2013
- Author(s)
  樋口周久、吉田清志、吉川秀樹
- Organizer
  第24回日本小児整形外科学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23659721
[Presentation] 間葉系幹細胞由来三次元人工組織(TEC)による成長軟骨修復2013
- Author(s)
  樋口周久、吉田清志、中村憲正、吉川秀樹
- Organizer
  第24回日本小児整形外科学会
- Place of Presentation
  横浜市
- Year and Date
  2013-11-08
- Data Source
  KAKENHI-PROJECT-23659721
[Presentation] Correction of knee deformity following physeal arrest with the aid of a three-dimensional computer system.2013
- Author(s)
  Higuchi C, Yoshida K, Murase T, Yoshikawa H.
- Organizer
  9th Asia Pacific Orthopaedic Association Paediatric Section Congress
- Place of Presentation
  Kuching, Malaysia
- Data Source
  KAKENHI-PROJECT-23659721
[Presentation] Treatment of growth arrest using an in vitro generated scaffold-free tissue engineered construct(TEC) derived from synovial mesenchymal stem cells2013
- Author(s)
  吉田清志、樋口周久、中村憲正、吉川秀樹
- Organizer
  International Society of Limb Salvage 17^<th> General Meeting
- Place of Presentation
  ボローニャ・イタリア
- Data Source
  KAKENHI-PROJECT-23659721
[Presentation] Correction of severe knee deformity following physeal arrest with the aid of a three-dimensional computer system and external fixator2012
- Author(s)
  吉田清志、樋口周久、村瀬剛、吉川秀樹
- Organizer
  2^<nd> World Congress on External Fixation and Bone Reconstruction
- Place of Presentation
  サルバドール・ブラジル
- Data Source
  KAKENHI-PROJECT-23659721
[Presentation] Percutaneous Epiphysiodesis Using Transphyseal Screw (PETS)を用いて変形矯正した片肢性骨端異形成症の1例2011
- Author(s)
  樋口周久、吉田清志、吉川秀樹
- Organizer
  第26回日本小児整形外科学会
- Place of Presentation
  京都市
- Year and Date
  2011-12-08
- Data Source
  KAKENHI-PROJECT-23659721
[Presentation] 片側肥大症による脚長差に対しスクリューを用いた経皮的成長抑制術を施行した1例2011
- Author(s)
  樋口周久、吉田清志、吉川秀樹
- Organizer
  第117回中部日本整形外科災害外科学会
- Place of Presentation
  宇部市
- Year and Date
  2011-10-28
- Data Source
  KAKENHI-PROJECT-23659721
[Presentation] Netrin-1 の骨芽細胞分化に対する影響2011
- Author(s)
  金子恵子、樋口周久、吉田清志、吉川秀樹
- Organizer
  第26回日本整形外科基礎学術集会
- Place of Presentation
  前橋市
- Year and Date
  2011-10-20
- Data Source
  KAKENHI-PROJECT-21591943
[Presentation] Netrin-1 inhibits the osteoblastic differentiation2011
- Author(s)
  Keiko Kneko, Chikahisa Higuchi
- Organizer
  第25回SICOT
- Place of Presentation
  prague
- Data Source
  KAKENHI-PROJECT-21591943
[Presentation] Netrin-1 suppresses osteoblastic differentiation.2011
- Author(s)
  金子恵子、樋口周久、吉田清志、吉川秀樹
- Organizer
  第25回 SICOT(Societe Internationale de Chirurgie Orthopedique et de Traumatologie) Triennial World Congress
- Place of Presentation
  プラハ・チェコ共和国
- Data Source
  KAKENHI-PROJECT-21591943
[Presentation] Netrin-1 の骨芽細胞分化に対する影響2011
- Author(s)
  金子恵子、樋口周久、吉田清志、吉川秀樹
- Organizer
  第29回日本骨代謝学会
- Place of Presentation
  大阪市
- Year and Date
  2011-07-28
- Data Source
  KAKENHI-PROJECT-21591943

1. MYOUI Akira (10263261)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. YOSHIKAWA Hideki (60191558)

# of Collaborated Projects: 2 results

# of Collaborated Products: 11 results
3. TANAKA Hiroyuki (00432542)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. NAKA Norifumi (90601964)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. OKAMOTO Mina (50457008)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. HONDA Hirotsugu (90624213)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. HASHIMOTO Nobuyuki (50324752)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. TAKENAKA Satoshi (00588379)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. KITA Keisuke (30588869)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. NAKATA Ken (00283747)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. MAE Tatsuo (10569734)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. NAKAMURA Norimasa (50273719)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. Sugano Nobuhiko (70273620)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. Ostuki Dai (40770681)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 吉田清志 (50645570)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Higuchi Chikahisa 樋口 周久

樋口 周久 ヒグチ チカヒサ

HIGUCHI Chikahisa 樋口 周久

Research Projects

Research Products

Co-Researchers

Costal cartilage regeneration study using 3D cultured cell transplantation for clinical application

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigation of the relationship between bone formation and inflammatory signalingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Investigation of relationship between hip dysplasia and mitochondrial DNA haplotype

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Optimization of Regeneration Technique for Large Bone Defect

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Regeneration of growth plate using mesenchymal stem cells

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Induction of differentiation to musculoskeletal tissue with autologous blood-derived scaffold and application to regenerative medicine

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Investigation of new relations between neural and skeletal tissuesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Hyaluronan inhibits BMP-induced osteoblast differentiation.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] MEK5 suppresses osteoblastic differentiation.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Bruton tyrosine kinase (Btk) suppresses osteoblastic differentiation.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Treatment of partial growth arrest using an in vitro-generated scaffold-free tissue-engineered construct derived from rabbit synovial mesenchymal stem cells2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Hip joint pigmented villonodular synovitis in a young girl : a case report2012

Author(s)

Journal Title

DOI

ISSN

Data Source

[Presentation] 陳旧性坐骨結節骨折に対して手術加療を施行した1例2013

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] Bruton's tyrosine kinase suppresses the osteoblast differentiation2013

Higuchi Chikahisa 樋口周久

樋口周久ヒグチチカヒサ

HIGUCHI Chikahisa 樋口周久