Yoshimoto Noriko 吉本則子

Researcher Number	40432736
Other IDs
Affiliation (Current)	2025: 山口大学, 大学院創成科学研究科, 准教授
Affiliation (based on the past Project Information) *help	2025: 山口大学, 大学院創成科学研究科, 准教授 2017 – 2023: 山口大学, 大学院創成科学研究科, 准教授 2017: 山口大学, 大学院創成科学研究科, 助教 2017: 山口大学, 自然科学研究科, 准教授 2016: 山口大学, 創成科学研究科, 助教 2014 – 2015: 山口大学, 医学(系)研究科(研究院), 助教
Review Section/Research Field	Principal Investigator Basic Section 27040:Biofunction and bioprocess engineering-related / Biofunction/Bioprocess
Keywords	Principal Investigator chromatography / PEGylation / イオン交換クロマトグラフィー / monolith / PEG / antibody / クロマトグラフィー / モノリス / PEG化タンパク質 / 疎水クロマトグラフィー … More / antibody drug conjugate / protein Lクロマトグラフィー / 疎水性クロマトグラフィー / 抗体薬物複合体 / PEG化DNA / 蛍光法 / ハイブリダイゼーション / DNA / クロマトグラフィー分離 / オリゴ核酸 / sequential process / solid phase reaction / 結合様式 / 吸着反応 / グラフト型ポリマーリガンド / アフニティークロマトグラフィー / クロマトグラフィープロセス / 連続式反応分離システム / 断片化抗体 / digestion / protein L chromatography / protein A chromatography / fragmented antibodies / continuous fragmentation / バイオリアクター / 固相反応 / リフォールディング / 変性 / PEGylated protein / 異性体分離 Less

夾雑カゼインミセルを吸着制御因子とする生乳エクソソームの高度精製操作Principal Investigator
- Principal Investigator
  
  吉本則子
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 27040:Biofunction and bioprocess engineering-related
- Research Institution
  Yamaguchi University
Chromatographic Process for the Steric Selective Synthesis and Separation of Antibody-Drug Conjugates on a Solid-Liquid InterfacePrincipal Investigator
- Principal Investigator
  
  Yoshimoto Noriko
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 27040:Biofunction and bioprocess engineering-related
- Research Institution
  Yamaguchi University
Development of sequential and reaction process with monolithic column module for small antibodies PEGylationPrincipal Investigator
- Principal Investigator
  
  Yoshimoto Noriko
- Project Period (FY)
  2018 – 2023
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research)
- Research Field
  
  Biofunction/Bioprocess
- Research Institution
  Yamaguchi University
Characterization and purification of oligonucleotides-polymer conjugates with higher-order structurePrincipal Investigator
- Principal Investigator
  
  Yoshimoto Noriko
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 27040:Biofunction and bioprocess engineering-related
- Research Institution
  Yamaguchi University
Surface modification of monolithic pore for solid phaseprotein PEGylation based on its mass transferPrincipal Investigator
- Principal Investigator
  
  YOSHIMOTO Noriko
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biofunction/Bioprocess
- Research Institution
  Yamaguchi University
Development of separation process for PEGylated positional isoforms based on the intrinsic interaction with specific structure on the solid-liquid interfacePrincipal Investigator
- Principal Investigator
  
  Yoshimoto Noriko
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biofunction/Bioprocess
- Research Institution
  Yamaguchi University

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014

All Journal Article Presentation

[Journal Article] Continuous Protein Modification and Separation Process with Chromatography2022
- Author(s)
  Yoshimoto Noriko
- Journal Title
  
  Japan Journal of Food Engineering
  
  Volume: 23 Issue: 1 Pages: 1-12
- DOI
  10.11301/jsfe.21601
- ISSN
  1345-7942, 1884-5924
- Year and Date
  2022-03-15
- Language
  Japanese
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K04793, KAKENHI-PROJECT-17KK0116
[Journal Article] Retention and diffusion characteristics of oligonucleotides in a solid phase with polymer grafted anion-exchanger2020
- Author(s)
  Chyi-ShinChen, Joao C.Simoes-Cardoso, Yuka Ikezuki, Daichi Tanaka, Noriko Yoshimoto, ShuichiYamamoto
- Journal Title
  
  Journal of chromatography A
  
  Volume: 1629 Pages: 1-7
- DOI
  10.1016/j.chroma.2020.461495
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K04854
[Journal Article] Methods for Measuring Molecular Diffusion Coefficients of Large Proteins and Bio-nanopartilces2017
- Author(s)
  濱地　正嵩、吉本　則子、山本　修一
- Journal Title
  
  Japan Journal of Food Engineering
  
  Volume: 18 Issue: 4 Pages: 187-191
- DOI
  10.11301/jsfe.17499
- NAID
  130006292653
- ISSN
  1345-7942, 1884-5924
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K18301
[Journal Article] Monolith disk chromatography separates PEGylated protein positional isoforms within minutes at low pressure2015
- Author(s)
  Yu Isakari, Ales Podgornik, Noriko Yoshimoto, Shuichi Yamamoto
- Journal Title
  
  Biotechnology Journal
  
  Volume: 11 Issue: 1 Pages: 100-106
- DOI
  10.1002/biot.201500294
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-14J01383, KAKENHI-PROJECT-26820363
[Presentation] クロマトグラフィーにおける抗体薬物複合体の保持溶出特性の解析2024
- Author(s)
  岩本望美、吉本則子
- Organizer
  化学工学会第89年会
- Data Source
  KAKENHI-PROJECT-21K04793
[Presentation] Antibody fragmentation and purification process using chromatography2024
- Author(s)
  吉本則子、国沢樹、窪田京平、三和諒太、Podgornik Ales
- Organizer
  化学工学会　第89年会
- Data Source
  KAKENHI-PROJECT-17KK0116
[Presentation] 抗体タンパク質の安定性を考慮した高温での断片化操作2023
- Author(s)
  国沢樹、吉本則子
- Organizer
  化学工学会第54回秋季大会
- Data Source
  KAKENHI-PROJECT-17KK0116
[Presentation] 断片化抗体のクロマトグラフィー分離操作2023
- Author(s)
  窪田京平、三和諒太、吉本則子
- Organizer
  「第45年会」・「膜シンポジウム2023」合同大会
- Data Source
  KAKENHI-PROJECT-17KK0116
[Presentation] 抗体薬物複合体の疎水クロマトグラフィー分離におけるリガンド種の影響2023
- Author(s)
  森田俊哉、吉本則子
- Organizer
  「第45年会」・「膜シンポジウム2023」合同大会プログラム
- Data Source
  KAKENHI-PROJECT-21K04793
[Presentation] 断片化抗体を用いたPEG化Fabの合成と分離2022
- Author(s)
  平岡　恋奈、吉本則子
- Organizer
  第24回化学工学会学生発表会
- Data Source
  KAKENHI-PROJECT-17KK0116
[Presentation] PEGリンカー鎖長が抗体薬物複合体のクロマト分離に与える影響2022
- Author(s)
  森田　俊哉、吉本則子
- Organizer
  日本食品工学会第23回（2022年度）年次大会（岡山）
- Data Source
  KAKENHI-PROJECT-21K04793
[Presentation] 抗体薬物複合体の分離に及ぼすPEGリンカー鎖長の影響2022
- Author(s)
  森田　俊哉、吉本　則子
- Organizer
  化学工学会第87年会
- Data Source
  KAKENHI-PROJECT-21K04793
[Presentation] イオン交換クロマトグラフィーを用いたペプチド修飾アルブミンの分離2022
- Author(s)
  濵中　誠司、吉本　則子
- Organizer
  化学工学会第87年会
- Data Source
  KAKENHI-PROJECT-21K04793
[Presentation] 固定化パパイン担体を用いた連続式IgG断片化-精製操作の検討2022
- Author(s)
  国沢　樹、吉本　則子
- Organizer
  化学工学会第87回年会
- Data Source
  KAKENHI-PROJECT-17KK0116
[Presentation] フロー式IgG抗体断片化反応に及ぼす温度の影響2022
- Author(s)
  国沢　樹、吉本　則子
- Organizer
  日本食品工学会第23回（2022年度）年次大会（岡山）
- Data Source
  KAKENHI-PROJECT-17KK0116
[Presentation] 抗体タンパク質のprotein A固定化クロマト担体における吸着現象の熱力学的解析2021
- Author(s)
  吉井秀和, 吉本　則子
- Organizer
  第23回化学工学会学生発表会
- Data Source
  KAKENHI-PROJECT-17KK0116
[Presentation] グラフト型ポリマー鎖を導入したモノリス型シリカカラムの評価2021
- Author(s)
  吉村裕輔, 吉本則子
- Organizer
  第23回化学工学会学生発表会
- Data Source
  KAKENHI-PROJECT-18K04854
[Presentation] 疎水性相互作用クロマトグラフィーにおける抗体薬物複合体溶出挙動のモデル解析2021
- Author(s)
  吉村　裕輔、吉本　則子
- Organizer
  分離技術会年会2021
- Data Source
  KAKENHI-PROJECT-21K04793
[Presentation] モノリスクロマトグラフィーによる修飾オリゴ核酸の構造解析2020
- Author(s)
  田中大智・Joao Cardoso・吉本則子・山本修一
- Organizer
  化学工学会第85年会
- Data Source
  KAKENHI-PROJECT-18K04854
[Presentation] Thermodynamic analysis of bovine serum albumin adsorption onto grafted ion exchange ligands2019
- Author(s)
  Nanako HOSHINO, Joao SIMOES-CARDOSO, Noriko YOSHIMOTO, Shuichi YAMAMOTO
- Organizer
  18th Asian Pacific Confederation of Chemical Engineering 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17KK0116
[Presentation] Analysis of PEGylated DNAs Retention in Electrostatic Interaction Chromatography2019
- Author(s)
  Noriko YOSHIMOTO, Yoshiatsu ONO, Shuichi YAMAMOTO
- Organizer
  18th Asian Pacific Confederation of Chemical Engineering Congress (APCChE 2019)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K04854
[Presentation] Control of protein PEGylation reaction on the solid phase2018
- Author(s)
  Yoshimoto Noriko, Kishi Yuhi, Ales Podgornik, Shuichi Yamamoto
- Organizer
  化学工学会第83年会
- Invited
- Data Source
  KAKENHI-PROJECT-16K18301
[Presentation] 2本鎖PEG修飾DNAの作製とイオン交換クロマトグラフィー保持特性の解析2018
- Author(s)
  尾野慈厚・吉本則子・山本修一
- Organizer
  化学工学会第50回秋季大会
- Data Source
  KAKENHI-PROJECT-18K04854
[Presentation] イオン交換クロマトグラフィーのオリゴDNA保持溶出挙動に及ぼすPEG修飾の影響2017
- Author(s)
  吉本則子,尾野慈厚,岸雄飛,山本修一
- Organizer
  化学工学会第82年会
- Place of Presentation
  芝浦工業大学(東京都江東区)
- Year and Date
  2017-03-08
- Data Source
  KAKENHI-PROJECT-16K18301
[Presentation] モノリスイオン交換クロマトグラフィーにおけるPEG化タンパク質異性体の分離機構2016
- Author(s)
  吉本　則子
- Organizer
  化学工学会第81年会
- Place of Presentation
  関西大学千里山キャンパス（大阪府、吹田市）
- Year and Date
  2016-03-14
- Data Source
  KAKENHI-PROJECT-26820363
[Presentation] ミニチュア化モノリスディスクの調製とその特性評価2016
- Author(s)
  荒川侑弥, 吉本則子,山本修一
- Organizer
  化学工学会中国四国支部大会2016
- Place of Presentation
  山口大学工学部(山口県宇部市)
- Year and Date
  2016-12-10
- Data Source
  KAKENHI-PROJECT-16K18301
[Presentation] 連続型タンパク質の固相PEG化反応プロセスの構築2016
- Author(s)
  岸雄飛,吉本則子,山本修一
- Organizer
  化学工学会中国四国支部大会2016
- Place of Presentation
  山口大学工学部(山口県宇部市)
- Year and Date
  2016-12-10
- Data Source
  KAKENHI-PROJECT-16K18301
[Presentation] Optimization of monomer separation processes by electrostatic-interaction chromatography2015
- Author(s)
  Shuichi Yamamoto , Noriko Yoshimoto , Yu Isakari , Ales Podgornik
- Organizer
  249th ACS National Meeting & Exposition
- Place of Presentation
  USA, Atlanta
- Year and Date
  2015-03-22
- Data Source
  KAKENHI-PROJECT-26820363
[Presentation] Analysis of chromatographic separation for PEGylated proteins on the basis of their diffusion behaviours in porous particle2014
- Author(s)
  Yu Isakari, Noriko Yoshimoto, Shuichi Yamamoto
- Organizer
  2nd International Symposium on Multiscale Multiphase Process Engineering (MMPE2)
- Place of Presentation
  Germany, Hamburg
- Year and Date
  2014-09-15
- Data Source
  KAKENHI-PROJECT-26820363
[Presentation] On-Column (solid-phase) Pegylation and Separation of Pegylated Proteins2014
- Author(s)
  Yu Isakari, Noriko Yoshimoto, Shuichi Yamamoto and Ales Podgornik
- Organizer
  14AIChE Annual meeting
- Place of Presentation
  USA, Atlanta
- Year and Date
  2014-11-18
- Data Source
  KAKENHI-PROJECT-26820363
[Presentation] Predicting the Efficiency of Capture Chromatography of Proteins2014
- Author(s)
  Noriko Yoshimoto, Yu Isakari, and Shuichi Yamamoto
- Organizer
  ICSST14
- Place of Presentation
  奈良県、奈良市、奈良県新公会堂
- Year and Date
  2014-10-31
- Data Source
  KAKENHI-PROJECT-26820363
[Presentation] Diffusion Coefficients of DNAs and Pegylated Proteins for Estimating the Performance of Chromatography2014
- Author(s)
  Masataka Hamachi, Yu Isakari, Noriko Yoshimoto, Shuichi Yamamoto and Ales Podgornik
- Organizer
  14AIChE Annual meeting
- Place of Presentation
  USA, Atlanta
- Year and Date
  2014-11-18
- Data Source
  KAKENHI-PROJECT-26820363

1. YAMAMOTO Shuichi (80144921)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
2. PODGORNIK Ales

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results

Yoshimoto Noriko 吉本 則子

Research Projects

Research Products

Co-Researchers

夾雑カゼインミセルを吸着制御因子とする生乳エクソソームの高度精製操作Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Chromatographic Process for the Steric Selective Synthesis and Separation of Antibody-Drug Conjugates on a Solid-Liquid InterfacePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of sequential and reaction process with monolithic column module for small antibodies PEGylationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Characterization and purification of oligonucleotides-polymer conjugates with higher-order structurePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Surface modification of monolithic pore for solid phaseprotein PEGylation based on its mass transferPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of separation process for PEGylated positional isoforms based on the intrinsic interaction with specific structure on the solid-liquid interfacePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Continuous Protein Modification and Separation Process with Chromatography2022

Author(s)

Journal Title

DOI

ISSN

Year and Date

Language

Data Source

[Journal Article] Retention and diffusion characteristics of oligonucleotides in a solid phase with polymer grafted anion-exchanger2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Methods for Measuring Molecular Diffusion Coefficients of Large Proteins and Bio-nanopartilces2017

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Monolith disk chromatography separates PEGylated protein positional isoforms within minutes at low pressure2015

Author(s)

Journal Title

DOI

Data Source

[Presentation] クロマトグラフィーにおける抗体薬物複合体の保持溶出特性の解析2024

Author(s)

Organizer

Data Source

[Presentation] Antibody fragmentation and purification process using chromatography2024

Author(s)

Organizer

Data Source

[Presentation] 抗体タンパク質の安定性を考慮した高温での断片化操作2023

Author(s)

Organizer

Data Source

[Presentation] 断片化抗体のクロマトグラフィー分離操作2023

Author(s)

Yoshimoto Noriko 吉本則子

[Presentation] 抗体タンパク質のprotein A固定化クロマト担体における吸着現象の熱力学的解析2021

[Presentation] 疎水性相互作用クロマトグラフィーにおける抗体薬物複合体溶出挙動のモデル解析2021

[Presentation] モノリスクロマトグラフィーによる修飾オリゴ核酸の構造解析2020