Fukuda Tomohiko 福田友彦

… Alternative Names

FUKUDA Tomohiko 福田友彦

福田友彦フクダトモヒコ

Less

Researcher Number	40433510
Other IDs
Affiliation (Current)	2025: 東北医科薬科大学, 薬学部, 准教授
Affiliation (based on the past Project Information) *help	2016 – 2024: 東北医科薬科大学, 薬学部, 准教授 2015: 東京大学, 大学院医学系研究科生殖・発達・加齢医学, 大学院生 2012 – 2014: 東北薬科大学, 薬学部, 准教授 2009 – 2011: 東北薬科大学, 薬学部, 講師 2006 – 2007: 東北薬科大学, 薬学部, 講師
Review Section/Research Field	Principal Investigator Biological pharmacy / Basic Section 47030:Pharmaceutical hygiene and biochemistry-related / Medical pharmacy Except Principal Investigator Basic Section 43030:Functional biochemistry-related / Medium-sized Section 49:Pathology, infection/immunology, and related fields / Tumor therapeutics / Obstetrics and gynecology / Medical genome science / Functional biochemistry
Keywords	Principal Investigator Fut8 / 糖鎖 / 神経炎症 / α1,6フコシル化 / ミクログリア / α1,6フコース / 薬学 / 糖転移酵素 / うつ / コアフコシル化 … More / IL-6 / N-型糖鎖 / 神経科学 / AMPA受容体 / ニューロン-グリア相互作用 / アストロサイト / モデルマウス / 神経疾患 / モデルマウ / 神経疾患ス / α1,6 フコース / AMPA 受容体 / 膜タンパク質 / フコース / 蛋白質 / ノックアウトマウス / 行動異常 / 生化学 / 生体分子 / 酵素 / 癌 … More Except Principal Investigator 糖鎖 / 糖転移酵素 / シグナル伝達 / N-型糖鎖 / N型糖鎖 / コアフコース / 細胞増殖 / Fut8 / インテグリン / 細胞移動 / GnT-III / 細胞接着 / 膜受容体 / がん薬剤耐性 / GnTーIII / 薬剤耐性 / 炎症 / 免疫グロブリンG / IgG / シグナル / UDP-GlcNAc輸送体 / O-GlcNAc / 細胞接着分子 / 受容体 / 細胞内シグナル / 細胞膜受容体 / がん / 分子メカニズム解明 / 抗酸化ストレス / 子宮体癌治療 / YM155 / サバイビン / SIRT6 / 子宮体癌 / Fut8欠損マウス / 肝がん / 増殖因子受容体 / 肝再生 / liver regeneration / α1,6フコース / カデニン / カドヘリン / GnT-V / TGF-β / E-カドヘリン / 細胞間接着 / EMT / N-結合型糖鎖 / 細胞接着因子 / E-cadherin / integrin / cell adhesion / N-glycosylation Less

Preventive effect of L-fucose administration on the onset of depression and its mechanismPrincipal Investigator
- Principal Investigator
  
  福田友彦
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Tohoku Medical and Pharmaceutical University
Analysis of underlying molecular mechanism for the regulation of chemoresistance by GnT-III
- Principal Investigator
  
  顧建国
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43030:Functional biochemistry-related
- Research Institution
  Tohoku Medical and Pharmaceutical University
Elucidation of molecular mechanism for IgG levels regulated by L-fucose
- Principal Investigator
  
  顧建国
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 49:Pathology, infection/immunology, and related fields
- Research Institution
  Tohoku Medical and Pharmaceutical University
Elucidation of neuroinflammation and brain function control mechanism by alpha1,6 fucosePrincipal Investigator
- Principal Investigator
  
  Fukuda Tomohiko
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Tohoku Medical and Pharmaceutical University
Functions of glycosylation in integrin-mediated outside-in and inside-out signaling
- Principal Investigator
  
  Gu Jianguo
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43030:Functional biochemistry-related
- Research Institution
  Tohoku Medical and Pharmaceutical University
Role of alpha1,6-fucosyltransferase Fut8 in neuron-glia interactionsPrincipal Investigator
- Principal Investigator
  
  Fukuda Tomohiko
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Tohoku Medical and Pharmaceutical University
Anticancer effects based on core fucose
- Principal Investigator
  
  GU Jianguo
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Tumor therapeutics
- Research Institution
  Tohoku Medical and Pharmaceutical University
The role of SIRT6 protein in gynecologic cancer.
- Principal Investigator
  
  Miyamoto Yuichiro
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Research Institute for Clinical Oncology, Saitama Cancer Center
Functional analysis of alpha1,6-fucosyltransferase deficient mice and underlying molecular mechanismPrincipal Investigator
- Principal Investigator
  
  FUKUDA Tomohiko
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Tohoku Pharmaceutical University
Liver regeneration is dependent on sugar chain
- Principal Investigator
  
  GU Jianguo
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Medical genome science
- Research Institution
  Tohoku Pharmaceutical University
脳神経系におけるα1,6フコース構造の役割Principal Investigator
- Principal Investigator
  
  福田友彦
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Tohoku Pharmaceutical University
Change of oligosaccharides in cell adhesion, and its roles
- Principal Investigator
  
  GU Jianguo
- Project Period (FY)
  2009 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  Tohoku Pharmaceutical University
N-結合型糖鎖によるラミニン-5の機能制御Principal Investigator
- Principal Investigator
  
  福田友彦
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (Start-up)
- Research Field
  
  Medical pharmacy
- Research Institution
  Tohoku Pharmaceutical University

[Book] Glycosignals in Cancer (Significance of FUT8 in Pancreatic Cancers and Others)2023
- Author(s)
  Koichi Furukawa and Minoru Fukuda (Liang, C., Wanli Song, W. and Gu, J.)
- Total Pages
  238
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-19H03184
[Book] Glycosignals in Cancer (Significance of FUT8 in Pancreatic Cancers and Others)2023
- Author(s)
  Koichi Furukawa and Minoru Fukuda (Liang, C., Wanli Song, W. and Gu, J.)
- Total Pages
  238
- Publisher
  Springer
- ISBN
  9789811977329
- Data Source
  KAKENHI-PROJECT-22K19443
[Book] α1,6-Fucosyltransferase 欠損マウスに見られた統合失調症様行動とその解析実験医学2013
- Author(s)
  顧建国, 谷口直之, 福田友彦
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-21370059
[Book] α1, 6-Fucosyltransferase欠損マウスに見られた統合失調症様行動とその解析, 実験医学2013
- Author(s)
  顧建国, 谷口直之, 福田友彦
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-23651196
[Book] α1,6-Fucosyltransferase欠損マウスに見られた統合失調症様行動とその解析2013
- Author(s)
  顧建国、谷口直之、福田友彦
- Total Pages
  6
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-21370059
[Book] α1,6-Fucosyltransferase欠損マウスに見られた統合失調症様行動とその解析2013
- Author(s)
  顧建国、谷口直之、福田友彦
- Total Pages
  6
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-23651196
[Book] 生物機能モデルと新しいリソース・リサーチツール2011
- Author(s)
  福田友彦
- Publisher
  株式会社エル・アイ・シー
- Data Source
  KAKENHI-PROJECT-22590071
[Book] 脳212011
- Author(s)
  福田友彦
- Publisher
  株式会社金芳堂
- Data Source
  KAKENHI-PROJECT-22590071
[Book] 『脳21-糖鎖と神経疾患』α1,6フコース欠損マウスと統合失調症様行動2011
- Author(s)
  福田友彦、谷口直之、顧建国
- Total Pages
  6
- Publisher
  金芳堂
- Data Source
  KAKENHI-PROJECT-21370059
[Book] 『モデル動物利用マニュアル』フコース転移酵素8(Fut8)2011
- Author(s)
  福田友彦、小林聡、顧建国、谷口直之
- Total Pages
  8
- Publisher
  エル・アイ・シ社
- Data Source
  KAKENHI-PROJECT-21370059
[Journal Article] Core fucosylation regulates the ovarian response via FSH receptor during follicular development2024
- Author(s)
  Wang Tiantong、Zhang Zhiwei、Qu Changduo、Song Wanli、Li Ming、Shao Xiaoguang、Fukuda Tomohiko、Gu Jianguo、Taniguchi Naoyuki、Li Wenzhe
- Journal Title
  
  Journal of Advanced Research
  
  Volume: XX Pages: 1-16
- DOI
  10.1016/j.jare.2024.01.025
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19443, KAKENHI-PROJECT-23K06734, KAKENHI-PROJECT-23K27133
[Journal Article] Exogenous l-fucose attenuates neuroinflammation induced by lipopolysaccharide2024
- Author(s)
  Xu Xing、Fukuda Tomohiko、Takai Jun、Morii Sayaka、Sun Yuhan、Liu Jianwei、Ohno Shiho、Isaji Tomoya、Yamaguchi Yoshiki、Nakano Miyako、Moriguchi Takashi、Gu Jianguo
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 300 Issue: 1 Pages: 105513-105513
- DOI
  10.1016/j.jbc.2023.105513
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19443, KAKENHI-PROJECT-22K06615, KAKENHI-PROJECT-22K06913, KAKENHI-PROJECT-21K06547, KAKENHI-PROJECT-23K27133
[Journal Article] BRCC36 associates with FLT3‐ITD to regulate its protein stability and intracellular signaling in acute myeloid leukemia2024
- Author(s)
  Liu Jianwei、Isaji Tomoya、Komatsu Sachiko、Sun Yuhan、Xu Xing、Fukuda Tomohiko、Fujimura Tsutomu、Takahashi Shinichiro、Gu Jianguo
- Journal Title
  
  Cancer Science
  
  Volume: 115 Issue: 4 Pages: 1196-1208
- DOI
  10.1111/cas.16090
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19443, KAKENHI-PROJECT-21K07346, KAKENHI-PROJECT-22K06615, KAKENHI-PROJECT-23K27133
[Journal Article] Expression of GnT-III decreases chemoresistance via negatively regulating P-glycoprotein expression: Involvement of the TNFR2-NF-κB signaling pathway2023
- Author(s)
  Song Wanli、Liang Caixia、Sun Yuhan、Morii Sayaka、Yomogida Shin、Isaji Tomoya、Fukuda Tomohiko、Hang Qinglei、Hara Akiyoshi、Nakano Miyako、Gu Jianguo
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 299 Issue: 4 Pages: 103051-103051
- DOI
  10.1016/j.jbc.2023.103051
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06547, KAKENHI-PROJECT-22K06615, KAKENHI-PROJECT-22K19443, KAKENHI-PROJECT-19H03184, KAKENHI-PROJECT-23K27133
[Journal Article] Focal-adhesion kinase regulates the sialylation of N-glycans via the PI4KIIα-PI4P pathway2023
- Author(s)
  Sun Yuhan、Isaji Tomoya、Oyama Yoshiyuki、Xu Xing、Liu Jianwei、Hanamatsu Hisatoshi、Yokota Ikuko、Miura Nobuaki、Furukawa Jun-ichi、Fukuda Tomohiko、Gu Jianguo
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 299 Issue: 8 Pages: 105051-105051
- DOI
  10.1016/j.jbc.2023.105051
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19443, KAKENHI-PROJECT-22K06615, KAKENHI-PROJECT-23K24759, KAKENHI-PROJECT-23K27133
[Journal Article] A highly specific antibody against the core fucose of the N-glycan in IgG identifies the pulmonary diseases and its regulation by CCL22023
- Author(s)
  Kanto Noriko、Ohkawa Yuki、Kitano Masato、Maeda Kento、Shiida Masafumi、Ono Tatsuya、Ota Fumi、Kizuka Yasuhiko、Kunimasa Kei、Nishino Kazumi、Mukai Mikio、Seike Masahiro、Azuma Arata、Harada Yoichiro、Fukuda Tomohiko、Gu Jianguo、Taniguchi Naoyuki
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 299 Issue: 12 Pages: 105365-105365
- DOI
  10.1016/j.jbc.2023.105365
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19443, KAKENHI-PROJECT-23K06420, KAKENHI-PROJECT-23K06734, KAKENHI-PROJECT-23K27133
[Journal Article] The ulcerative colitis-associated gene FUT8 regulates the quantity and quality of secreted mucins2022
- Author(s)
  Cantero-Recasens Gerard、Burballa Carla、Ohkawa Yuki、Fukuda Tomohiko、Harada Yoichiro、Curwin Amy J.、Brouwers Nathalie、Thun Gian A.、Gu Jianguo、Gut Ivo、Taniguchi Naoyuki、Malhotra Vivek、IBD Character Consortium
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 119 Issue: 43 Pages: 1-12
- DOI
  10.1073/pnas.2205277119
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06547, KAKENHI-PROJECT-22K19443, KAKENHI-PROJECT-19H03184, KAKENHI-PROJECT-20K07629
[Journal Article] α-1,6-Fucosyltransferase Is Essential for Myogenesis in Zebrafish2022
- Author(s)
  Hayashiji Nozomi、Kawahara Genri、Xu Xing、Fukuda Tomohiko、Kerever Aurelien、Gu Jianguo、Hayashi Yukiko K.、Arikawa-Hirasawa Eri
- Journal Title
  
  Cells
  
  Volume: 12 Issue: 1 Pages: 144-144
- DOI
  10.3390/cells12010144
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06547, KAKENHI-PROJECT-22K19443, KAKENHI-PROJECT-19H03184, KAKENHI-PROJECT-20K08089, KAKENHI-PROJECT-18K15130, KAKENHI-PROJECT-20H03594
[Journal Article] O-GlcNAcylation Regulates β1,4-GlcNAc-branched N-glycan Biosynthesis Via the OGT/SLC35A3/GnT-IV Axis.2022
- Author(s)
  Song, W., Isaji, T., Nakano, M., Liang C., Fukuda, T.and Gu, J.
- Journal Title
  
  FASEB J.
  
  Volume: 36 Issue: 2 Pages: 210-210
- DOI
  10.1096/fj.202101520r
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-20H04909, KAKENHI-PROJECT-19H02922, KAKENHI-PROJECT-19H03184, KAKENHI-WRAPUP-22H04899
[Journal Article] α1,6-Fucosyltransferase contributes to cell migration and proliferation as well as to cancer stemness features in pancreatic carcinoma.2021
- Author(s)
  Caixia Liang, Tomohiko Fukuda, Tomoya Isaji, Chengwei Duan, Wanli Song, Yuqin Wang, Jianguo Gu
- Journal Title
  
  Biochimica et biophysica acta. General subjects
  
  Volume: 1865 Issue: 6 Pages: 129870-129870
- DOI
  10.1016/j.bbagen.2021.129870
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-20H04909, KAKENHI-PROJECT-19H03184, KAKENHI-PROJECT-19K07049
[Journal Article] Deficiency of core fucosylation activates cellular signaling dependent on FLT3 expression in a Ba/F3 cell system2020
- Author(s)
  Duan Chengwei、Fukuda Tomohiko、Isaji Tomoya、Qi Feng、Yang Jie、Wang Yuqin、Takahashi Shinichiro、Gu Jianguo
- Journal Title
  
  The FASEB Journal
  
  Volume: 34 Issue: 2 Pages: 3239-3252
- DOI
  10.1096/fj.201902313rr
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07049, KAKENHI-PUBLICLY-18H04868, KAKENHI-PROJECT-19H03184, KAKENHI-PROJECT-17K09019
[Journal Article] Identification of the minimal N-glycosylation on integrin α5β1 required for its inhibitory effect on EGFR signaling and cell proliferation2020
- Author(s)
  Hou Sicong、Hang Qinglei、Isaji Tomoya、Fukuda Tomohiko、Gu Jianguo
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 523 Issue: 1 Pages: 226-232
- DOI
  10.1016/j.bbrc.2019.11.188
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07049, KAKENHI-PUBLICLY-18H04868, KAKENHI-PROJECT-19H03184
[Journal Article] Loss of core fucosylation enhances the anticancer activity of cytotoxic T lymphocytes by increasing PD-1 degradation.2020
- Author(s)
  Nianzhu Zhang, Ming Li, Xing Xu, Yingshu Zhang, Yancheng Liu, Meng Zhao, Peng Li, Jun Chen, Tomohiko Fukuda, Jianguo Gu, Xun Jin, Wenzhe Li.
- Journal Title
  
  European journal of immunology
  
  Volume: 50 Issue: 11 Pages: 1820-1833
- DOI
  10.1002/eji.202048543
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-20H04909, KAKENHI-PROJECT-19H03184
[Journal Article] EpCAM associates with integrin and regulates cell adhesion in cancer cells2020
- Author(s)
  Yang Jie、Isaji Tomoya、Zhang Guowei、Qi Feng、Duan Chengwei、Fukuda Tomohiko、Gu Jianguo
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 522 Issue: 4 Pages: 903-909
- DOI
  10.1016/j.bbrc.2019.11.152
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07049, KAKENHI-PUBLICLY-18H04868, KAKENHI-PROJECT-19H03184
[Journal Article] ST3GAL3, ST3GAL4, and ST3GAL6 differ in their regulation of biological functions via the specificities for the α2,3‐sialylation of target proteins2020
- Author(s)
  Qi Feng、Isaji Tomoya、Duan Chengwei、Yang Jie、Wang Yuqin、Fukuda Tomohiko、Gu Jianguo
- Journal Title
  
  The FASEB Journal
  
  Volume: 34 Issue: 1 Pages: 881-897
- DOI
  10.1096/fj.201901793r
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07049, KAKENHI-PUBLICLY-18H04868, KAKENHI-PROJECT-19H03184
[Journal Article] Core Fucosylation of Intestinal Epithelial Cells Protects Against Salmonella Typhi Infection via Up-Regulating the Biological Antagonism of Intestinal Microbiota.2020
- Author(s)
  Sijia Hao, Qingjie Fan, Yaqiang Bai, Hui Fang, Jiaorui Zhou, Tomohiko Fukuda, Jianguo Gu, Ming Li, Wenzhe Li.
- Journal Title
  
  Frontiers in microbiology
  
  Volume: 11
- DOI
  10.3389/fmicb.2020.01097
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-20H04909, KAKENHI-PROJECT-19H03184
[Journal Article] Deficiency of α1,6-fucosyltransferase promotes neuroinflammation by increasing the sensitivity of glial cells to inflammatory mediators2019
- Author(s)
  Lu Xu、Zhang Dongmei、Shoji Hayato、Duan Chengwei、Zhang Guowei、Isaji Tomoya、Wang Yuqin、Fukuda Tomohiko、Gu Jianguo
- Journal Title
  
  Biochimica et Biophysica Acta (BBA) - General Subjects
  
  Volume: 1863 Issue: 3 Pages: 598-608
- DOI
  10.1016/j.bbagen.2018.12.008
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-18H04868, KAKENHI-PROJECT-15H04354, KAKENHI-PROJECT-17K08284
[Journal Article] N-Glycoform-dependent interactions of megalin with its ligands.2017
- Author(s)
  Hirano M, Totani K, Fukuda T, Gu J, Suzuki A
- Journal Title
  
  Biochim Biophys Acta
  
  Volume: 1861 Issue: 1 Pages: 3106-3118
- DOI
  10.1016/j.bbagen.2016.10.015
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K14408
[Journal Article] A key regulator of cell adhesion: Identification and characterization of important N-glycosylation sites on integrin α5 for cell migration.2017
- Author(s)
  Hang, Q., Isaji, T., Hou, S., Wang, Y., Fukuda, T. and Gu, J.
- Journal Title
  
  Mol. Cell. Biol.
  
  Volume: 37 Issue: 9
- DOI
  10.1128/mcb.00558-16
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04354, KAKENHI-PROJECT-15K14408
[Journal Article] Expression of N-acetylglucosaminyltransferase III suppresses α2,3 sialylation and its distinctive functions in cell migration are attributed to α2,6 sialylation levels.2016
- Author(s)
  Lu, J., Isaji, T., Im, S., Fukuda, T., Kameyama, A. and Gu, J.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 291 Issue: 11 Pages: 5708-20
- DOI
  10.1074/jbc.m115.712836
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K14408, KAKENHI-PROJECT-15H04354
[Journal Article] N-Glycosylation of integrin α5 acts as a switch for EGFR-mediated complex formation of integrin α5β1 to α6β4.2016
- Author(s)
  Hang, Q., Isaji, T., Hou, S., Zhou, Y., Fukuda, T. and Gu, J.
- Journal Title
  
  Sci. Rep.
  
  Volume: 10 Issue: 1 Pages: 1-15
- DOI
  10.1038/srep33507
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15H04354, KAKENHI-PROJECT-25461164, KAKENHI-PROJECT-15K14408
[Journal Article] Importance of membrane-proximal N-glycosylation on integrin β1 in its activation and complex formation.2016
- Author(s)
  Hou S, Hang Q, Isaji T, Lu J, Fukuda T, Gu J.
- Journal Title
  
  FASEB J.
  
  Volume: 30 Pages: 4120-4131
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K14408
[Journal Article] Putative tumor suppression function of SIRT6 in endometrial cancer.2015
- Author(s)
  Fukuda T, Wada-Hiraike O, Oda K, Tanikawa M, Makii C, Inaba K, Miyasaka A, Miyamoto Y, Yano T, Maeda D, Sasaki T, Kawana K, Fukayama M, Osuga Y, Fujii T.
- Journal Title
  
  FEBS Lett
  
  Volume: 589 Issue: 17 Pages: 2274-2281
- DOI
  10.1016/j.febslet.2015.06.043
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10704, KAKENHI-PROJECT-26462515, KAKENHI-PROJECT-26861348
[Journal Article] HAND2-mediated proteolysis negatively regulates the function of estrogen receptor α.2015
- Author(s)
  Fukuda T, Shirane A, Wada-Hiraike O, Oda K, Tanikawa M, Sakuabashi A, Hirano M, Fu H, Morita Y, Miyamoto Y, Inaba K, Kawana K, Osuga Y, Fujii T.
- Journal Title
  
  Mol Med Rep.
  
  Volume: 12(4) Pages: 5538-44
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26861348
[Journal Article] CCAR2 negatively regulates nuclear receptor LXRα by competing with SIRT1 deacetylase.2015
- Author(s)
  Sakurabashi A, Wada-Hiraike O, Hirano M, Fu H, Isono W, Fukuda T, Morita Y, Tanikawa M, Miyamoto Y, Oda K, Kawana K, Osuga Y, Fujii T.
- Journal Title
  
  J Steroid Biochem Mol Biol.
  
  Volume: 149 Pages: 80-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26861348
[Journal Article] Integrin α5 Suppresses the Phosphorylation of Epidermal Growth Factor Receptor and Its Cellular Signaling of Cell Proliferation via N-Glycosylation2015
- Author(s)
  Hang Q, Isaji T, Hou S, Im S, Fukuda T, Gu J.
- Journal Title
  
  J Biol Chem
  
  Volume: 290 Issue: 49 Pages: 29345-60
- DOI
  10.1074/jbc.m115.682229
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461164, KAKENHI-PROJECT-15K14408, KAKENHI-PROJECT-15H04354
[Journal Article] Loss of α1,6-fucosyltransferase decreased hippocampal long-term potentiation: implications for core fucosylation in the regulation of AMPA receptor heteromerization and cellular signaling.2015
- Author(s)
  Gu, W., Fukuda, T., Isaji, T., Hang, Q., Lee, H., Sakai, S., Morise, J., Mitoma, J., Higashi, H., Taniguchi, N., Yawo, H., Oka, S. and Gu, J.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 290 Issue: 28 Pages: 17566-75
- DOI
  10.1074/jbc.m114.579938
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K14408, KAKENHI-PROJECT-15K15025, KAKENHI-PUBLICLY-15H01413, KAKENHI-PLANNED-23110006, KAKENHI-PROJECT-25250001, KAKENHI-PROJECT-15H04354, KAKENHI-PROJECT-15H04700, KAKENHI-PROJECT-26291021
[Journal Article] Loss of α1,6-fucosyltransferase decreased hippocampal long-term potentiation: implication of core fucosylation in the regulation of AMPA receptor heteromerization and cellular signaling2015
- Author(s)
  Wei Gu, Tomohiko Fukuda, Tomoya Isaji, Qinglei Hang, Ho-hsun Lee, Seiichiro Sakai, Jyoji Morise, Junya Mitoma, Hideyoshi Higashi, Naoyuki Taniguchi, Hiromu Yawo, Shogo Oka, Jianguo Gu
- Journal Title
  
  J Biol Chem.
  
  Volume: in　press
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24590087
[Journal Article] An oncogenic protein Golgi phosphoprotein 3 up-regulates cell migration via sialylation2014
- Author(s)
  Isaji, T., Im, S., Gu, W., Wang, Y., Hang, H., Lu, J., Fukuda, T., Hashii, N., Takakura, D., Kawasaki, N., Miyoshi, H. and Gu, J.
- Journal Title
  
  J Biol. Chem
  
  Volume: (in press)
- Data Source
  KAKENHI-PROJECT-21370059
[Journal Article] α1,6-Fucosylation regulates neurite formation via the activin/phospho-Smad2 pathway in PC12 cells: the implicated dual effects of Fut8 for TGF-β/activin-mediated signaling.2013
- Author(s)
  Gu, W., Fukuda, T., Isaji, T., Hashimoto, H., Wang., Y and Gu, J.
- Journal Title
  
  FASEB J
  
  Volume: 27 Issue: 10 Pages: 3947-3958
- DOI
  10.1096/fj.12-225805
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21370059, KAKENHI-PROJECT-23651196, KAKENHI-PUBLICLY-24110513, KAKENHI-PROJECT-24570169, KAKENHI-PROJECT-24590087
[Journal Article] α1, 6-Fucosylation regulates neurite formation via the activin/phospho-Smad2 pathway in PC12 cells : the implicated dual effects of Fut8 for TGF-β/activin-mediated signaling2013
- Author(s)
  Gu, W., Fukuda, T., Isaji, T., Hashimoto, H., Wang., Y and Gu, J.
- Journal Title
  
  FASEB J
  
  Volume: 27 Pages: 3947-3958
- Data Source
  KAKENHI-PROJECT-21370059
[Journal Article] α1, 6-Fucosylation regulates neurite formation via the activin/phospho-Smad2 pathway in PC12 cells : the implicated dual effects of Fut8 for TGF-β/activin-mediated signaling2013
- Author(s)
  Gu, W., Fukuda, T., Isaji, T., Hashimoto, H., Wang., Y and Gu, J
- Journal Title
  
  FASEB J
  
  Volume: 27 Pages: 3947-3958
- Data Source
  KAKENHI-PROJECT-23651196
[Journal Article] Potential roles of N-glycosylation in cell adhesion.2012
- Author(s)
  Gu, J., et al
- Journal Title
  
  Glycoconj J
  
  Volume: 29 Issue: 8-9 Pages: 599-607
- DOI
  10.1007/s10719-012-9386-1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21370059, KAKENHI-PROJECT-23651196, KAKENHI-PROJECT-23790373, KAKENHI-PROJECT-24570169, KAKENHI-PROJECT-24590087, KAKENHI-PUBLICLY-24110513
[Journal Article] Roles of N-acetylglucosaminyltransferase III in epithelial-to-mesenchymal transition induced by transforming growth factor β1 (TGF-β1) in epithelial cell lines.2012
- Author(s)
  Xu Q, Isaji T, Lu Y, Gu W, Kondo M, Fukuda T, Du Y, Gu J.
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 286 Issue: 20 Pages: 16563-74
- DOI
  10.1074/jbc.m111.262154
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590087
[Journal Article] Basement membrane assembly of the integrin α8β1 ligand nephronectin requires Fraser syndrome-associated proteins.2012
- Author(s)
  Kiyozumi D, Takeichi M, Nakano I, Sato Y, Fukuda T, Sekiguchi K.
- Journal Title
  
  The Journal of Cell Biology
  
  Volume: 197 Issue: 5 Pages: 677-89
- DOI
  10.1083/jcb.201203065
- NAID
  120006626430
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590087, KAKENHI-PLANNED-22122006
[Journal Article] Roles of N-acetylglucosaminyltransferase III in epithelial-to-mesenchymal transition induced by TGF-β1 in epithelial cell lines2012
- Author(s)
  Xu, Q., Isaji, T., Lu, Y., Gu, W., Kondo, M., Fukuda, T., Du, Y. and Gu, J.
- Journal Title
  
  J Biol Chem
  
  Volume: 287 Pages: 16563-74
- Data Source
  KAKENHI-PROJECT-21370059
[Journal Article] α1, 6-Fucosyltransferase-deficient mice exhibit multiple behavioral abnormalities associated with a schizophrenia-like phenotype : importance of the balance between the dopamine and serotonin systems2011
- Author(s)
  Fukuda, T., Hashimoto, H., Okayasu, N., Kameyama, A., Onogi, H., Nakagawasai, O, Nakazawa, T., Kurosawa, T., Hao, Y., Isaji, T., Tadano, T., Narimatsu, H., Taniguchi, N. and Gu, J.
- Journal Title
  
  J. Biol. Chem
  
  Volume: 286 Pages: 18434-43
- Data Source
  KAKENHI-PROJECT-21370059
[Journal Article] α1,6-Fucosyltransferase-deficient mice exhibit multiple behavioral abnormalities associated with a schizophrenia-like phenotype : importance of the balance between the dopamine and serotonin systems2011
- Author(s)
  Fukuda, T., et al
- Journal Title
  
  J.Biol.Chem.
  
  Volume: 286 Pages: 18434-43
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21370059
[Journal Article] α1,6-Fucosyltransferase-deficient mice exhibit multiple behavioral abnormalities associated with a schizophrenia-like phenotype: importance of the balance between the dopamine and serotonin systems.2011
- Author(s)
  Fukuda, T., et al
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 286 Pages: 18434-43
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23651196
[Journal Article] Wnt/β-catenin Signaling Down-regulates N-Acetylglucosaminyltransferase III Expression : The implication of two mutually exclusive pathways for regulation2011
- Author(s)
  Xu, Q., Akama, R., Isaji, T., Lu, Y., Hashimoto, H., Kariya, Y., Fukuda, T., Du, Y., and Gu, J.
- Journal Title
  
  J. Biol. Chem
  
  Volume: 286 Pages: 4310-8
- Data Source
  KAKENHI-PROJECT-21370059
[Journal Article] alpha 1,6-Fucosyltransferase-deficient Mice Exhibit Multiple Behavioral Abnormalities Associated with a Schizophrenia-like Phenotype2011
- Author(s)
  Tomohiko Fukuda, Hirokazu Hashimoto, Natsumi Okayasu, Akihiko Kameyama, Hiroshi Onogi, Osamu Nakagawasai, Takahiro Nakazawa, Tomoyo Kurosawa, Yan Hao, Tomoya Isaji, Takeshi Tadano, Hisashi Narimatsu
- Journal Title
  
  THE JOURNAL OF BIOLOGICAL CHEMISTRY
  
  Volume: 286 Issue: 21 Pages: 18434-18443
- DOI
  10.1074/jbc.m110.172536
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590071, KAKENHI-PROJECT-22770130
[Journal Article] An N-glycosylation site on the beta-propeller domain of the integrin alpha5 subunit plays key roles in both its function and site-specific modification by beta1, 4-N-acetylglucosaminyltransferase III2009
- Author(s)
  Sato, Y., Isaji, T., Tajiri, M., Yoshida-Yamamoto, S., Yoshinaka, T., Somehara, T., Fukuda, T., Wada, Y. and Gu, J.
- Journal Title
  
  J. Biol. Chem
  
  Volume: 284 Pages: 11873-81
- Data Source
  KAKENHI-PROJECT-21370059
[Journal Article] N-glycosylation of the I-like domain of beta1 integrin is essential for beta1 integrin expression and biological function : Identification of the minimal N-glycosylation requirement for alpha 5beta 12009
- Author(s)
  Isaji, T., Sato, Y., Fukuda, T. and Gu, J.
- Journal Title
  
  J. Biol. Chem
  
  Volume: 284 Pages: 12207-16
- Data Source
  KAKENHI-PROJECT-21370059
[Journal Article] Loss of α1,6-fucosyltransferase inhibits chemical-induced hepatocellular carcinoma and tumorigenesis by down-regulating several cell signaling pathways
- Author(s)
  Yuqin Wang, Tomohiko Fukuda, Tomoya Isaji, Jishun Lu, Sanghun Im, Qinglei Hang, Wei Gu, Sicong Hou, Kazuaki Ohtsubo, Jianguo Gu
- Journal Title
  
  The FASEB Journal
  
  Volume: 29 Issue: 8 Pages: 3217-3227
- DOI
  10.1096/fj.15-270710
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26430118, KAKENHI-PROJECT-15K14408, KAKENHI-PROJECT-15H04354
[Presentation] L-フコース投与によるLPS誘発性脳内炎症抑制とその機序2024
- Author(s)
  福田友彦、徐興、高井淳、森井爽、孫鈺涵、劉健偉、大野詩歩、伊左治知弥、山口芳樹、中の三弥子、森口尚、顧建国
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-21K06547
[Presentation] L-fucose投与によるLPS誘発性脳内炎症抑制とその機序2024
- Author(s)
  福田友彦, 徐興, 高井淳, 伊左治知弥, 山口芳樹, 中ノ三弥子, 森口尚, 顧建国
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-23K27133
[Presentation] 脱ユビキチン酵素BRCC36を標的とした急性骨髄性白血病治療の可能性2024
- Author(s)
  伊左治知弥, 劉建偉, 小松祥子, 福田友彦,藤村務, 高橋伸一郎, 顧建国
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-23K27133
[Presentation] がん薬剤耐性におけるN型糖鎖の変化とその意義2023
- Author(s)
  宋万里、梁彩霞、孫鈺涵、森井彩、蓬田伸、伊左治知弥、福田友彦、原明義、中の三弥子, 顧　建国
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-22K19443
[Presentation] The expression of GnT-III decreases chemoresistance via negatively　regulating P-glycoprotein expression in K562 cells2023
- Author(s)
  孫鈺涵，伊左治知弥，福田友彦，顧建国
- Organizer
  日本生化学会東北支部第89回例会
- Data Source
  KAKENHI-PROJECT-23K27133
[Presentation] L-フコース投与による脳内炎症抑制とその機序2023
- Author(s)
  福田友彦，徐興，高井淳，森井爽，孫鈺涵，劉健偉，伊左治知弥，中の三弥子，森口尚，顧建国
- Organizer
  第６２回日本薬学会東北支部大会
- Data Source
  KAKENHI-PROJECT-21K06547
[Presentation] Exogenous L-Fucose attenuates neuroinflammation induced by lipopolysaccharide in Fut8 heterozygous knockout mouse2023
- Author(s)
  徐興, 福田友彦, 高井淳, 中ノ三弥子, 森口尚, 顧建国
- Organizer
  第96回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-22K19443
[Presentation] がん薬剤耐性におけるN型糖鎖の変化とその意義2023
- Author(s)
  宋万里、梁彩霞、孫鈺涵、森井彩、蓬田伸、伊左治知弥、福田友彦、原明義、中の三弥子, 顧　建国
- Organizer
  日本薬学会第１４３年会
- Data Source
  KAKENHI-PROJECT-19H03184
[Presentation] Fut8ヘテロ欠損マウスへのL-フコース投与によるLPS 誘発性神経炎症抑制とその機序2023
- Author(s)
  福田友彦，徐興, 高井淳，森井爽，孫鈺涵，劉健偉，伊左治知弥，中の三弥子，森口尚，顧建国
- Organizer
  第42回日本糖質学会年会
- Data Source
  KAKENHI-PROJECT-21K06547
[Presentation] BRCC36とFLT3-ITDの相互作用による蛋白質の安定性と細胞内シグナルへの影響2023
- Author(s)
  伊左治　知弥、劉健偉，段程偉，小松祥子，福田友彦，藤村務，髙橋伸一郎，顧建国
- Organizer
  第42回日本糖質学会年会
- Data Source
  KAKENHI-PROJECT-22K19443
[Presentation] Exogenous L-Fucose attenuates neuroinflammation induced by lipopolysaccharide in Fut8 heterozygous knockout mouse2023
- Author(s)
  徐興, 福田友彦, 高井淳, 中ノ三弥子, 森口尚, 顧建国
- Organizer
  第96回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-23K27133
[Presentation] Alteration in N‐Glycans in Cancer Drug Resistance: A New Function of GnT-III2023
- Author(s)
  Jianguo Gu, Tomoya Isaji and Tomohiko Fukuda
- Organizer
  International symposium on glycoconjugates (Glyco26)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19443
[Presentation] Alteration in N‐Glycans in Cancer Drug Resistance2023
- Author(s)
  Jianguo Gu, Tomoya Isaji and Tomohiko Fukuda
- Organizer
  International symposium on glycoconjugates (Glyco26)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K27133
[Presentation] A novel molecular mechanism for sialylation regulated through the integrin-FAK-PI4K-GOLPH3-sialytransferase axis2022
- Author(s)
  Yuhan Sun, Tomoya Isaji, Tomohiko Fukuda and Jianguo Gu
- Organizer
  The 29th FAOBMB & 2022 CSBMB
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03184
[Presentation] インテグリン-FAK-PI4K軸を介したN-型糖鎖のシアリル化制御2022
- Author(s)
  伊左治　知弥、孫　鈺涵、福田　友彦、顧　建国
- Organizer
  第41回日本糖質学会
- Data Source
  KAKENHI-PROJECT-19H03184
[Presentation] A novel regulatory mechanism for sialylation via the integrin-FAK-PI4K-GOLPH3-ST axis2022
- Author(s)
  Yuhan Sun, Tomoya Isaji, Tomohiko Fukuda and Jianguo Gu
- Organizer
  Sialoglyco2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19443
[Presentation] 接着斑キナーゼはPI4KIIα-PI4P経路を介してシアリル化N-型糖鎖を制御する2022
- Author(s)
  伊左治　知弥、孫　鈺涵、福田　友彦、顧　建国
- Organizer
  第95回日本生化学会
- Data Source
  KAKENHI-PROJECT-19H03184
[Presentation] 糖ヌクレオチド輸送体（SLC35 ファミリー）を介した O-GlcNAc 修飾と N-型糖鎖生合成の関連性について2022
- Author(s)
  関川諒, 宋万里, 伊左治知弥, 福田友彦, 顧建国
- Organizer
  第16回東北糖鎖研究会
- Data Source
  KAKENHI-PROJECT-22K19443
[Presentation] 糖ヌクレオチド輸送体（SLC35 ファミリー）を介した O-GlcNAc 修飾と N-型糖鎖生合成の関連性について2022
- Author(s)
  関川諒, 宋万里, 伊左治知弥, 福田友彦, 顧建国
- Organizer
  第16回東北糖鎖研究会
- Data Source
  KAKENHI-PROJECT-19H03184
[Presentation] UDP-GlcNAc を共通ドナー基質とする O-GlcNAc、ヒアルロン酸と N型糖鎖間の相互作用に関して2022
- Author(s)
  小野拓朗, 黒田喜幸, 伊左治知弥, 福田友彦, 顧建国
- Organizer
  第16回東北糖鎖研究会
- Data Source
  KAKENHI-PROJECT-19H03184
[Presentation] 接着斑キナーゼはPI4KIIα-PI4P経路を介してシアリル化N-型糖鎖を制御する2022
- Author(s)
  伊左治　知弥、孫　鈺涵、福田　友彦、顧　建国
- Organizer
  第95回日本生化学会
- Data Source
  KAKENHI-PROJECT-22K19443
[Presentation] OGTはOGT/SLC35A3/GnT-IV軸を介してβ1,4-GlcNAc分岐型 N型糖鎖の生合成を制御する2022
- Author(s)
  宋万里, 伊左治知弥, 中の三弥子, 福田友彦, 顧建国
- Organizer
  第16回東北糖鎖研究会
- Data Source
  KAKENHI-PROJECT-19H03184
[Presentation] A novel molecular mechanism for sialylation regulated through the integrin-FAK-PI4K-GOLPH3-sialytransferase axis2022
- Author(s)
  Yuhan Sun, Tomoya Isaji, Tomohiko Fukuda and Jianguo Gu
- Organizer
  The 29th FAOBMB & 2022 CSBMB
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19443
[Presentation] A novel regulatory mechanism for sialylation via the integrin-FAK-PI4K-GOLPH3-ST axis2022
- Author(s)
  Yuhan Sun, Tomoya Isaji, Tomohiko Fukuda and Jianguo Gu
- Organizer
  Sialoglyco2022
- Data Source
  KAKENHI-PROJECT-19H03184
[Presentation] Focal adhesion kinaseのO-GlcNAc修飾による細胞機能の制御2021
- Author(s)
  伊左治知弥, 大山嘉順, 孫玉涵, 福田友彦, 黒田喜幸, 顧建国
- Organizer
  第94回日本生化学会
- Data Source
  KAKENHI-PROJECT-19H03184
[Presentation] Focal adhesion kinase (FAK)のO-GlcNAc 修飾による細胞接着斑の形成と細胞機能の制御2021
- Author(s)
  伊左治知弥, 大山嘉順, 孫玉涵, 福田友彦, 黒田喜幸, 顧建国
- Organizer
  第40回日本糖質学会年会
- Data Source
  KAKENHI-PROJECT-19H03184
[Presentation] O-GlcNAcylation Regulates β1,4-GlcNAc-branched N-glycan Biosynthesis Via the OGT/SLC35A3/GnT-IV Axis2021
- Author(s)
  宋万里, 伊左治知弥, 中の三弥子, 福田友彦, 黒田喜幸, 顧建国
- Organizer
  第40回日本糖質学会年会
- Data Source
  KAKENHI-PROJECT-19H03184
[Presentation] O-GlcNAcylation regulates β1,4-GlcNAc-branched N-glycan biosynthesis via the OGT/SLC35A3/GnT-IV Axis2021
- Author(s)
  宋万里, 伊左治知弥, 中の三弥子, 福田友彦, 黒田喜幸, 顧建国
- Organizer
  第94回日本生化学会
- Data Source
  KAKENHI-PROJECT-19H03184
[Presentation] 膵がん細胞のがん幹細胞性の獲得と細胞移動・増殖におけるFUT8の役割2021
- Author(s)
  梁彩霞, 福田友彦, 伊左治知弥, 黒田喜幸, 顧建国
- Organizer
  第15回東北糖鎖研究会
- Data Source
  KAKENHI-PROJECT-19H03184
[Presentation] O-GlcNAcylation Regulates β1,4-GlcNAc-branched N-glycan Biosynthesis Via the OGT/SLC35A3/GnT-IV Axis2021
- Author(s)
  宋万里, 伊左治知弥, 中の三弥子, 福田友彦, 黒田喜幸, 顧建国
- Organizer
  第15回東北糖鎖研究会
- Data Source
  KAKENHI-PROJECT-19H03184
[Presentation] 糖鎖による膜受容体の選別輸送ゾーンの特異性とその制御機構の解明2020
- Author(s)
  顧建国,　福田友彦,　伊左治知弥
- Organizer
  第２回オルガネラゾーン研究会
- Data Source
  KAKENHI-PROJECT-19H03184
[Presentation] FUT8の発現は膵がん細胞の移動・増殖・がん幹細胞性に重要な役割を果たす。2020
- Author(s)
  梁彩霞, 福田友彦, 伊左治知弥, 顧建国
- Organizer
  第14回東北糖鎖研究会
- Data Source
  KAKENHI-PROJECT-19H03184
[Presentation] 糖鎖修飾阻害薬の急性前骨髄球性白血病細胞のレチノイン酸分化誘導に及ぼす影響に関する解析2020
- Author(s)
  沖津庸子,　福田友彦,顧建国,　髙橋伸一郎
- Organizer
  第67回日本臨床検査医学会
- Data Source
  KAKENHI-PROJECT-19H03184
[Presentation] Deficiency of core fucosylation activates FLT3 signaling via induction of dimeric formation2020
- Author(s)
  Chengwei Duan, Tomohiko Fukuda, Tomoya Isaji, Shinichiro Takahashia and Jianguo Gu
- Organizer
  12th International Symposium on Glycosyltransferases
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03184
[Presentation] インテグリンとFLT3受容体における糖鎖機能と制御機構2020
- Author(s)
  顧建国,　伊左治知弥,　福田友彦
- Organizer
  第93回日本生化学会
- Data Source
  KAKENHI-PROJECT-19H03184
[Presentation] 接着斑キナーゼ(FAK)のO-GlcNAc修飾による細胞機能への影響2020
- Author(s)
  大山嘉順, 伊左治知弥, 福田友彦, 顧建国
- Organizer
  第14回東北糖鎖研究会
- Data Source
  KAKENHI-PROJECT-19H03184
[Presentation] 膵がん細胞の遊走・増殖・がん幹細胞的性質保持におけるFUT8発現の重要性2020
- Author(s)
  福田友彦, 梁彩霞, 伊左治知弥, 顧建国
- Organizer
  第39回日本糖質学会年会
- Data Source
  KAKENHI-PROJECT-19H03184
[Presentation] FLT3を介したシグナル伝達におけるコアフコシル化の重要性2020
- Author(s)
  段程偉, 福田友彦, 伊左治知弥, 髙橋伸一郎, 顧建国
- Organizer
  第14回東北糖鎖研究会
- Data Source
  KAKENHI-PROJECT-19H03184
[Presentation] コアフコースによるグリア細胞過活性化の抑制2019
- Author(s)
  福田友彦, 庄子隼人, 陸需, 張冬梅, 伊左治知弥, 顧建国
- Organizer
  92回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-17K08284
[Presentation] 糖鎖修飾によるインテグリンの選別輸送ゾーンの制御について2019
- Author(s)
  顧建国, 伊左治知弥, 福田友彦, 戸島拓郎, 中野明彦
- Organizer
  第3回オルガネラゾーン研究会
- Data Source
  KAKENHI-PROJECT-19H03184
[Presentation] 細胞内外の糖鎖発現とインテグリン機能とその制御2019
- Author(s)
  顧建国，伊左治知弥，福田友彦
- Organizer
  第38回日本糖質学会年会
- Data Source
  KAKENHI-PROJECT-19H03184
[Presentation] α1,6フコシルトランスフェラーゼ(Fut8)欠損によるグリア細胞の活性化2019
- Author(s)
  福田友彦，庄子隼人，陸需，張冬梅，伊左治知弥，顧建国
- Organizer
  第38回日本糖質学会年会
- Data Source
  KAKENHI-PROJECT-17K08284
[Presentation] PI4KIIαとインテグリンα3β1の複合体形成による癌細胞におけるN-型糖鎖の調節2019
- Author(s)
  伊左治知弥, ニンショウフン, 亀山昭彦, 福田友彦, 顧建国
- Organizer
  第92回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-19H03184
[Presentation] コアフコースによるグリア細胞過活性化の抑制2019
- Author(s)
  福田友彦, 庄子隼人, 陸需, 張冬梅, 伊左治知弥, 顧建国
- Organizer
  第92回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-19H03184
[Presentation] α1,6フコシルトランスフェラーゼ(Fut8)欠損によるグリア細胞の活性化2019
- Author(s)
  福田友彦、庄子隼人、陸需、張冬梅、伊左治知弥、顧建国
- Organizer
  第38回日本糖質学会年会
- Data Source
  KAKENHI-PROJECT-19H03184
[Presentation] Roles of α1,6-fucosyltion in glial cells2018
- Author(s)
  福田友彦・陸需・庄子隼人・張冬梅・伊左治知弥・顧建国
- Organizer
  第９１回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-17K08284
[Presentation] Functional analysis of N-glycosylation in neuroninflammation2017
- Author(s)
  張冬梅、福田友彦、顧建国
- Organizer
  第２１回アジア地域招聘研究者研究発表会
- Place of Presentation
  野村コンファレンスプラザ日本橋YUITO(東京都中央区）
- Data Source
  KAKENHI-PROJECT-15K14408
[Presentation] N-glycosylation on Integrin α5 define active integrin α5β1 internalization to regulate cell migration2016
- Author(s)
  杭慶雷、伊左治知弥、侯思聡、福田友彦、顧建国
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台国際センター（宮城県仙台市）
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-15K14408
[Presentation] The importance of N-glycosylation on integrin β1 in its activation and complex formation2016
- Author(s)
  侯思聡、伊左治知弥、杭慶雷、福田友彦、顧建国
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台国際センター（宮城県仙台市）
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-15K14408
[Presentation] N-glycosylation on Integrin α5 serve as an on/off switch to regulate EGFR signaling2016
- Author(s)
  杭慶雷、伊左治知弥、侯思聡、福田友彦、顧建国
- Organizer
  日本生化学会東北支部
- Place of Presentation
  弘前大学（青森県弘前市）
- Year and Date
  2016-05-21
- Data Source
  KAKENHI-PROJECT-15K14408
[Presentation] PIKIIαによるインテグリンα3β1の制御とンN-型糖鎖調節2016
- Author(s)
  伊左治　知弥、任翔フン、福田　友彦、顧　建国
- Organizer
  第３５回日本糖質学会年会
- Place of Presentation
  高知文化プラザかるぽーと（高知県高知市）
- Year and Date
  2016-09-01
- Data Source
  KAKENHI-PROJECT-15K14408
[Presentation] Fut8の機能解析：肝臓および脳神経組織におけるコアフコースの重要性2015
- Author(s)
  福田友彦、王玉琴、伊左治知弥、顧建国
- Organizer
  第９回東北糖鎖研究会•東北薬科大学分子生体膜研究所シンポジウム
- Place of Presentation
  東北医科薬科大学（宮城県仙台市）
- Year and Date
  2015-09-04
- Data Source
  KAKENHI-PROJECT-15K14408
[Presentation] 肝がんおよび肝再生におけるコアフコースの機能2015
- Author(s)
  福田　友彦、顧　建国
- Organizer
  第38回日本分子生物学会年会、第88回日本生化学会大会合同大会
- Place of Presentation
  神戸国際会議場（兵庫県神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15K14408
[Presentation] HAND2 could serve as a tumor suppressor by inhibiting the transactivation function of ERα in endometrial carcinoma2015
- Author(s)
  Tomohiko Fukuda, Osamu Wada-Hiraike, Katsutoshi Oda, Akira Shirane, Michihiro Tanikawa, Ayako Sakuabashi, Mana Hirano, Yuichiro Miyamoto, Kenbun Sone, Kanako Inaba, Kei Kawana, Yutaka Osuga, and Tomoyuki Fujii
- Organizer
  第67回日本産科婦人科学会学術講演会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2015-04-09
- Data Source
  KAKENHI-PROJECT-26861348
[Presentation] Mice lacking fucosyltransferase 8 exhibit abnormal behavioral abnormalities associated with a schizophrenia-like phenotype2013
- Author(s)
  Fukuda T., Gu W., Isaji T., Taniguchi n. Gu J.
- Organizer
  Glycoconjugates-22(GLYCO-22)
- Place of Presentation
  Dalian
- Data Source
  KAKENHI-PROJECT-24590087
[Presentation] 肝臓がん形成および肝再生におけるα1,6フコシル化の重要性2013
- Author(s)
  王玉琴、福田友彦、顧威、伊左治知弥、三善英知、顧建国
- Organizer
  第７回東北糖鎖研究会
- Place of Presentation
  新潟
- Data Source
  KAKENHI-PROJECT-23651196
[Presentation] 肝臓がん形成および肝再生におけるα1, 6 フコシル化の重要性2013
- Author(s)
  王玉琴, 福田友彦, 顧威, 伊左治知弥, 三善英知, 顧建国
- Organizer
  第7回東北糖鎖研究会
- Place of Presentation
  新潟
- Data Source
  KAKENHI-PROJECT-23651196
[Presentation] α1,6 フコース転移酵素Fut8 欠損による海馬機能の変化2012
- Author(s)
  福田友彦、顧威、橋本弘和、酒井誠一郎、王玉琴、伊左治知弥、八尾寛、東秀好、顧建国
- Organizer
  第31回日本糖質学会年
- Place of Presentation
  鹿児島
- Data Source
  KAKENHI-PROJECT-24590087
[Presentation] 脳神経における α1,6 フコースの機能解析2012
- Author(s)
  福田友彦, 顧威, 伊左治知弥, 王玉琴, 顧建国
- Organizer
  第4回東北糖鎖研究会
- Place of Presentation
  青森
- Data Source
  KAKENHI-PROJECT-24590087
[Presentation] インテグリンに付加された糖鎖の意義について2011
- Author(s)
  伊左治知弥, 陸瑩瑩, 福田友彦, 顧建国
- Organizer
  第77回日本生化学会東北支部会
- Place of Presentation
  東北大学
- Data Source
  KAKENHI-PROJECT-21370059
[Presentation] インテグリンα3鎖に付加されたN-結合型糖鎖の多機能性2011
- Author(s)
  陸瑩瑩、伊左治知弥、福田友彦、顧建国
- Organizer
  第８４回日本生化学会
- Place of Presentation
  京都国際会議場
- Data Source
  KAKENHI-PROJECT-23651196
[Presentation] Fut8欠損マウスにみられる統合失調症様行動と脳内神経伝達物質バランスの変化2011
- Author(s)
  福田友彦、伊左治知弥、顧建国
- Organizer
  第30回日本糖質学会年会
- Place of Presentation
  長岡
- Data Source
  KAKENHI-PROJECT-21370059
[Presentation] α1,6フコース転移酵素(Fut8)欠損マウスにみられる統合失調症様行動2011
- Author(s)
  福田友彦
- Organizer
  第131回日本薬学会年会
- Place of Presentation
  グランシップ・ツインメッセ静岡(静岡)
- Year and Date
  2011-03-31
- Data Source
  KAKENHI-PROJECT-22590071
[Presentation] GOLPH3 によるインテグリンβ1の糖鎖付加および機能制御2011
- Author(s)
  伊左治知弥、近藤円、福田友彦、顧建国
- Organizer
  第８４回日本生化学会
- Place of Presentation
  京都国際会議場
- Data Source
  KAKENHI-PROJECT-23651196
[Presentation] Fut8欠損マウスに認められた統合失調症様行動と脳内神経伝達物質バランスの変化2011
- Author(s)
  福田友彦, 橋本弘和, 岡安夏実, 亀山昭彦, 小野木弘志, 中川西修, 中澤孝浩, 伊左治知弥, 只野武, 成松久, 谷口直之, 顧建国
- Organizer
  第30回日本糖質学会年会
- Place of Presentation
  長岡リリックホール(新潟県)
- Data Source
  KAKENHI-PROJECT-22590071
[Presentation] 癌遺伝子GOLPH3によるインテグリンbeta1の糖鎖変化とその機能調節2011
- Author(s)
  近藤円、伊左治知弥、福田友彦、顧建国
- Organizer
  第5回東北糖鎖研究会
- Place of Presentation
  東北大学
- Data Source
  KAKENHI-PROJECT-21370059
[Presentation] インテグリンα3鎖に付加されたN-結合型糖鎖の多機能性2011
- Author(s)
  陸瑩瑩、伊左治知弥、福田友彦、顧建国
- Organizer
  第84回日本生化学会
- Place of Presentation
  京都国際会議場
- Data Source
  KAKENHI-PROJECT-21370059
[Presentation] 癌遺伝子GOLPH3によるインテグリンbeta1の糖鎖変化とその機能調節2011
- Author(s)
  近藤円、伊左治知弥、福田友彦、顧建国
- Organizer
  第５回東北糖鎖研究会
- Place of Presentation
  東北大学
- Data Source
  KAKENHI-PROJECT-23651196
[Presentation] インテグリンに付加された糖鎖の意義について2011
- Author(s)
  伊左治知弥、陸瑩瑩、福田友彦、顧建国
- Organizer
  第77回日本生化学会　東北支部会
- Place of Presentation
  東北大学
- Data Source
  KAKENHI-PROJECT-23651196
[Presentation] GOLPH3によるインテグリンβ1の糖鎖付加および機能制御2011
- Author(s)
  伊左治知弥、近藤円、福田友彦、顧建国
- Organizer
  第84回日本生化学会
- Place of Presentation
  京都国際会議場
- Data Source
  KAKENHI-PROJECT-21370059
[Presentation] Fut8欠損マウスにみられる統合失調症様行動と脳内神経伝達物質バランスの変化2011
- Author(s)
  福田友彦、伊左治知弥、顧建国
- Organizer
  第３０回日本糖質学会年会
- Place of Presentation
  長岡
- Data Source
  KAKENHI-PROJECT-23651196
[Presentation] インテグリンα5β1に付加されたN-結合型糖鎖による機能制御2010
- Author(s)
  伊左治知弥、川村千尋、陸螢螢、福田友彦、顧建国
- Organizer
  第49回日本薬学会東北支部大会
- Place of Presentation
  奥羽大学
- Year and Date
  2010-10-24
- Data Source
  KAKENHI-PROJECT-21370059
[Presentation] インテグリンの機能を制御するN-結合型糖鎖2010
- Author(s)
  伊左治知弥、川村千尋、陸蛍蛍、福田友彦、顧建国
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  大阪
- Year and Date
  2010-09-22
- Data Source
  KAKENHI-PROJECT-21370059
[Presentation] GOLPH3によるインテグリンβ1の糖鎖付加及び機能制御2010
- Author(s)
  我妻孝則、伊左治知弥、福田友彦、顧建国
- Organizer
  第4回東北糖鎖研究会
- Place of Presentation
  福島
- Year and Date
  2010-12-04
- Data Source
  KAKENHI-PROJECT-21370059
[Presentation] Fut8 knockdownによるPC12細胞の機能変化2010
- Author(s)
  橋本弘和、福田友彦、岡安夏美、許青松、伊左治知弥、顧建国
- Organizer
  第4回東北糖鎖研究会
- Place of Presentation
  福島
- Year and Date
  2010-12-04
- Data Source
  KAKENHI-PROJECT-21370059
[Presentation] インテグリンα3鎖に付加されたN-結合型糖鎖の重要性2010
- Author(s)
  陸螢螢、伊左治知弥、福田友彦、顧建国
- Organizer
  第4回東北糖鎖研究会
- Place of Presentation
  福島
- Year and Date
  2010-12-04
- Data Source
  KAKENHI-PROJECT-21370059
[Presentation] Wnt/β-catenin Signaling Down-regulates N-Acetylglucosaminyltransferase III Expression : Implication of Two Mutually Exclusive Pathways For the Regulation2010
- Author(s)
  許青松、伊左治知弥、陸蛍蛍、橋本弘和、福田友彦、顧建国
- Organizer
  第83回日本生化学会大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-21370059
[Presentation] インテグリンα5鎖のN-結合型糖鎖付加と細胞内シグナル伝達との関連性2010
- Author(s)
  川村千尋、伊左治知弥、福田友彦、顧建国
- Organizer
  第4回東北糖鎖研究会
- Place of Presentation
  福島
- Year and Date
  2010-12-04
- Data Source
  KAKENHI-PROJECT-21370059
[Presentation] インテグリンの機能を制御するN-結合型糖鎖2010
- Author(s)
  伊左治知弥, 川村千尋, 陸蛍蛍, 福田友彦, 顧建国
- Organizer
  第69回日本癌学会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-21370059
[Presentation] al, 6フコース転移酵素(Fut8)欠損マウスにおける統合失調症様行動2009
- Author(s)
  福田友彦、顧建国
- Organizer
  第75回日本生化学会東北支部会
- Place of Presentation
  東北大学
- Year and Date
  2009-05-09
- Data Source
  KAKENHI-PROJECT-21370059
[Presentation] Impairment of hippocampal long-term potentiation and enhanced AMPA receptor complexes formation in alpha 1,6-fucosyltransferase-deficient mice
- Author(s)
  Tomohiko Fukuda, Wei Gu, Tomoya Isaji, Seiichiro Sakai, Jyoji Morise, Hideyoshi Higashi, Naoyuki Taniguchi, Hiromu Yawo, Shogo Oka Jianguo Gu
- Organizer
  9th International Symposium on Glycosyltransferases
- Place of Presentation
  Porto, Portugal
- Year and Date
  2014-06-18 – 2014-06-21
- Data Source
  KAKENHI-PROJECT-24590087
[Presentation] Functional analysis of α1,6-fucosyltransferase deficient mice and underlying molecular mechanism
- Author(s)
  福田友彦、顧建国
- Organizer
  第57回日本神経化学会
- Place of Presentation
  奈良県文化会館・奈良県新公会堂(奈良県奈良市)
- Year and Date
  2014-09-29 – 2014-10-01
- Data Source
  KAKENHI-PROJECT-24590087

1. GU Jianguo (40260369)

# of Collaborated Projects: 7 results

# of Collaborated Products: 103 results
2. ISAJI Tomoya (80433514)

# of Collaborated Projects: 3 results

# of Collaborated Products: 58 results
3. 高橋伸一郎 (40375069)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
4. Miyamoto Yuichiro (70634955)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
5. 苅谷慶喜 (00458217)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. 中の三弥子 (40397724)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
7. 下平秀樹 (70373214)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 山口芳樹 (90323451)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. 亀岡淳一 (30261621)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. SAKURABASHI Ayako

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
11. HIRAIKE Osamu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. OHTSUBO Kazuaki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Fukuda Tomohiko 福田 友彦

FUKUDA Tomohiko 福田 友彦

福田 友彦 フクダ トモヒコ

Research Projects

Research Products

Co-Researchers

Preventive effect of L-fucose administration on the onset of depression and its mechanismPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of underlying molecular mechanism for the regulation of chemoresistance by GnT-III

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of molecular mechanism for IgG levels regulated by L-fucose

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of neuroinflammation and brain function control mechanism by alpha1,6 fucosePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Functions of glycosylation in integrin-mediated outside-in and inside-out signaling

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Role of alpha1,6-fucosyltransferase Fut8 in neuron-glia interactionsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Anticancer effects based on core fucose

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The role of SIRT6 protein in gynecologic cancer.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Functional analysis of alpha1,6-fucosyltransferase deficient mice and underlying molecular mechanismPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Liver regeneration is dependent on sugar chain

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

脳神経系におけるα1,6フコース構造の役割Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Change of oligosaccharides in cell adhesion, and its roles

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

N-結合型糖鎖によるラミニン-5の機能制御Principal Investigator

Principal Investigator

Fukuda Tomohiko 福田友彦

FUKUDA Tomohiko 福田友彦

福田友彦フクダトモヒコ

[Book] α1,6-Fucosyltransferase 欠損マウスに見られた統合失調症様行動とその解析実験医学2013