Mitsunaga Makoto 光永眞人

… Alternative Names

光永眞人ミツナガマコト

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Researcher Number	40433990
Other IDs
Affiliation (Current)	2025: 東京慈恵会医科大学, 医学部, 講師
Affiliation (based on the past Project Information) *help	2025: 東京慈恵会医科大学, 医学部, 講師 2015 – 2023: 東京慈恵会医科大学, 医学部, 講師 2014: 東京慈恵会医科大学, 医学部, 助教 2009: 慈恵医大, 医学部, 助教 2008: Jikei University School of Medicine, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 90110:Biomedical engineering-related / Medium-sized Section 90:Biomedical engineering and related fields / Tumor therapeutics / Infectious disease medicine / Gastroenterology Except Principal Investigator Infectious disease medicine
Keywords	Principal Investigator 近赤外光 / 分子標的薬 / 分子イメージング / 抗体療法 / がん / precision medicine / 抗体 / 血管新生 / 新生血管 / リポソーム … More / 蛍光プローブ / 癌 / 光線免疫療法 / 細菌感染症 / 薬剤耐性菌 / 黄色ブドウ球菌 / 感染症 / インターフェロンガンマ / 腫瘍抗原 / 細胞傷害性T細胞 / 樹状細胞 … More Except Principal Investigator 光線免疫療法 / 感染症治療学 / 光免疫療法 / 近赤外光 / 分子標的薬 / 薬剤耐性菌 Less

光反応型エンジニアド分子標的薬による新規病態制御法の開発Principal Investigator
- Principal Investigator
  
  光永眞人
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 90110:Biomedical engineering-related
- Research Institution
  Jikei University School of Medicine
機能性高分子化合物による新規プレシジョンメカノセラピーの開発Principal Investigator
- Principal Investigator
  
  光永眞人
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 90:Biomedical engineering and related fields
- Research Institution
  Jikei University School of Medicine
Development of a theranostic system for abnormal angiogenesisPrincipal Investigator
- Principal Investigator
  
  光永眞人
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 90110:Biomedical engineering-related
- Research Institution
  Jikei University School of Medicine
Nanotheranostic system for cancer with human safety energy devicePrincipal Investigator
- Principal Investigator
  
  Mitsunaga Makoto
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 90110:Biomedical engineering-related
- Research Institution
  Jikei University School of Medicine
Antibody-selective elimination of drug-resistant pathogens with near-infrared light
- Principal Investigator
  
  ITO KIMIHIRO
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Infectious disease medicine
- Research Institution
  Jikei University School of Medicine
Development of bacteria-targeted photoimmunotherapyPrincipal Investigator
- Principal Investigator
  
  Mitsunaga Makoto
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Infectious disease medicine
- Research Institution
  Jikei University School of Medicine
Development of molecular-specific cancer theranostics utilizing near-infrared light and monoclonal antibodyPrincipal Investigator
- Principal Investigator
  
  Mitsunaga Makoto
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Tumor therapeutics
- Research Institution
  Jikei University School of Medicine
光線力学療法を併用した新規樹状細胞癌ワクチン療法の開発Principal Investigator
- Principal Investigator
  
  光永眞人
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Jikei University School of Medicine

All 2020 2019 2018 2017 2016 2015 2008

All Journal Article Presentation Patent

[Journal Article] Cancer neovasculature-targeted near-infrared photoimmunotherapy (NIR-PIT) for gastric cancer: different mechanisms of phototoxicity compared to cell membrane-targeted NIR-PIT2020
- Author(s)
  Takashi Nishimura, Makoto Mitsunaga, Kimihiro Ito, Hisataka Kobayashi, Masayuki Saruta
- Journal Title
  
  Gastric Cancer
  
  Volume: 23 Issue: 1 Pages: 82-94
- DOI
  10.1007/s10120-019-00988-y
- NAID
  40022121454
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H03523
[Journal Article] Photoimmunotherapy targeting biliary‐pancreatic cancer with humanized anti‐TROP2 antibody2019
- Author(s)
  Takashi Nishimura, Makoto Mitsunaga, Ryoichi Sawada, Masayuki Saruta, Hisataka Kobayashi, Noriko Matsumoto, Toru Kanke, Hiroyuki Yanai, Koji Nakamura
- Journal Title
  
  Cancer Medicine
  
  Volume: 8 Issue: 18 Pages: 7781-7792
- DOI
  10.1002/cam4.2658
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H03523
[Journal Article] Near-Infrared Photochemoimmunotherapy by Photoactivatable Bifunctional Antibody－Drug Conjugates Targeting Human Epidermal Growth Factor Receptor 2 Positive Cancer2017
- Author(s)
  Ito K, Mitsunaga M, Nishimura T, Saruta M, Iwamoto T, Kobayashi H, Tajiri H
- Journal Title
  
  Bioconjugate Chemistry
  
  Volume: 印刷中 Issue: 5 Pages: 1458-1469
- DOI
  10.1021/acs.bioconjchem.7b00144
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26710010
[Journal Article] Combination photoimmunotherapy with monoclonal antibodies recognizing different epitopes of human epidermal growth factor receptor 2: an assessment of phototherapeutic effect based on fluorescence molecular imaging.2016
- Author(s)
  Ito K, Mitsunaga M, Nishimura T, Kobayashi H, Tajiri H.
- Journal Title
  
  Oncotarget
  
  Volume: 7 Issue: 12 Pages: 14143-52
- DOI
  10.18632/oncotarget.7490
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26710010
[Journal Article] Molecular targeted photoimmunotherapy for HER2-positive human gastric cancer in combination with chemotherapy results in improved treatment outcomes through different cytotoxic mechanisms.2016
- Author(s)
  Ito K, Mitsunaga M, Arihiro S, Saruta M, Matsuoka M, Kobayashi H, Tajiri H.
- Journal Title
  
  BMC Cancer
  
  Volume: 16 Issue: 1 Pages: 37-37
- DOI
  10.1186/s12885-016-2072-0
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26710010
[Journal Article] In vitro generation of cytotoxic and regulatory T cells by fusions of human dendritic cells and hepatocellular carcinoma cells2008
- Author(s)
  Koido S, Mitsunaga M, et.al.
- Journal Title
  
  J Transl Med 6
  
  Pages: 51-51
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790512
[Patent] 血管を標的とする抗体と光増感剤とのコンジュゲート2018
- Inventor(s)
  光永眞人
- Industrial Property Rights Holder
  東京慈恵会医科大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2018-042803
- Filing Date
  2018
- Data Source
  KAKENHI-PROJECT-26710010
[Presentation] 内視鏡分子イメージングから光免疫療法へ -theranostics 最前線-2020
- Author(s)
  光永眞人、小林久隆
- Organizer
  第58回日本癌治療学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-18H03523
[Presentation] がん光免疫療法を基盤とした新たな抗感染療法の開発2020
- Author(s)
  光永眞人、小林久隆
- Organizer
  第94回日本細菌学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-18H03523
[Presentation] 消化器悪性腫瘍に対する光免疫療法の利活用へ向けた臨床前検討2019
- Author(s)
  光永眞人、西村尚、伊藤公博
- Organizer
  日本レーザー医学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-18H03523
[Presentation] In vivo molecular theranostics for biliary-pancreatic cancer using near-infrared photoimmunotherapy2019
- Author(s)
  Makoto Mitsunaga, Takashi Nishimura
- Organizer
  World Molecular Imaging Congress 2019
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H03523
[Presentation] TROP2-targeted photoimmunotherapy in experimental human pancreatic cancer2019
- Author(s)
  Takashi Nishimura, Makoto Mitsunaga
- Organizer
  AACR Annual Meeting 2019
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H03523
[Presentation] In vivo biliary-pancreatic cancer-targeted photoimmunotherapy using humanized anti-TROP2 monoclonal antibody2019
- Author(s)
  Takashi Nishimura, Makoto Mitsunaga
- Organizer
  日本癌学会総会
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H03523
[Presentation] 蛍光プローブを用いた消化器がん分子イメージングと分子標的特異的がん近赤外光線治療2018
- Author(s)
  光永眞人、伊藤公博、西村尚
- Organizer
  日本消化器関連学会週間　JDDW2018
- Invited
- Data Source
  KAKENHI-PROJECT-18H03523
[Presentation] 光免疫療法　　研究開発から実用化まで2018
- Author(s)
  光永眞人
- Organizer
  第7回日本免疫・細胞治療学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-18H03523
[Presentation] Vascular endothelial growth factor receptor 2 targeted near-infrared photoimmunotherapy (NIR-PIT); different mechanism of phototoxicity compared to cell membrane targeted NIR-PIT2018
- Author(s)
  Takashi Nishimura, Kimihiro Ito, Makoto Mitsunaga
- Organizer
  AACR Annual Meeting 2018
- Invited
- Data Source
  KAKENHI-PROJECT-18H03523
[Presentation] Near-infrared molecular imaging guided photochemoimmunotherapy by bifunctional antibody-drug conjugates targeting HER2-positive cancer cells2017
- Author(s)
  Makoto Mitsunaga, Kimihiro Ito, Takashi Nishimura
- Organizer
  World Molecular Imaging Congress 2017
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26710010
[Presentation] 多機能抗体薬物複合体を用いたHER2特異的近赤外光線療法2017
- Author(s)
  伊藤公博、光永眞人
- Organizer
  日本癌学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-26710010
[Presentation] HER2-targeted near-infrared photoimmunotherapy based on fluorescence molecular imaging in experimental animal model2016
- Author(s)
  Mitsunaga M
- Organizer
  日本癌学会総会
- Place of Presentation
  横浜
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26710010
[Presentation] Strategies to enhance a treatment effect of HER2-targeted theranostic photoimmunotherapy in experimental human gastric cancer2016
- Author(s)
  Mitsunaga M, Ito K, Nishimura T, Tajiri H
- Organizer
  Digestive Disease Week 2016
- Place of Presentation
  アメリカ、サンディエゴ
- Year and Date
  2016-05-21
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26710010
[Presentation] Molecular Targeted Theranostic Photoimmunochemotherapy for HER2- Positive Human Gastric Cancer in Mice2015
- Author(s)
  Kimihiro Ito, Makoto Mitsunaga, Seiji Arihiro, Masayuki Saruta, Mika Matsuoka, Hisao Tajiri
- Organizer
  Digestive Disease Week 2015
- Place of Presentation
  アメリカ、ワシントン
- Year and Date
  2015-05-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26710010
[Presentation] 蛍光分子イメージングをガイドとした光線治療法の開発2015
- Author(s)
  光永眞人、伊藤公博、西村尚、田尻久雄
- Organizer
  第100回日本消化器内視鏡学会関東地方会
- Place of Presentation
  東京
- Year and Date
  2015-06-13
- Data Source
  KAKENHI-PROJECT-26710010
[Presentation] 蛍光法によるセンチネルリンパ節検出からセンチネルリンパ節微小転移検出を目指して2015
- Author(s)
  光永眞人、小林久隆
- Organizer
  第17回SNNS研究会学術集会
- Place of Presentation
  横浜
- Year and Date
  2015-11-13
- Data Source
  KAKENHI-PROJECT-26710010
[Presentation] 蛍光プローブを用いた内視鏡分子イメージングの現状と今後の可能性2015
- Author(s)
  光永眞人、炭山和毅、小林雅邦、伊藤公博、西村尚、岩崎哲良ほか
- Organizer
  第100回日本消化器内視鏡学会関東地方会
- Place of Presentation
  東京
- Year and Date
  2015-06-14
- Data Source
  KAKENHI-PROJECT-26710010
[Presentation] Molecular targeted theranostic photoimmunotherapy combining two types of monoclonal antibodies targeting different epitopes of HER2: enhanced phototherapeutic effect based on fluorescence molecular imaging2015
- Author(s)
  Kimihiro Ito, Makoto Mitsunaga, Seiji Arihiro, Masayuki Saruta, Mika Matsuoka, Hisao Tajiri
- Organizer
  World Molecular Imaging Congress 2015
- Place of Presentation
  アメリカ、ホノルル
- Year and Date
  2015-09-02
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26710010
[Presentation] Optical sentinel node biopsy for gastric cancer with fluorescent tracer and cancer-specific monoclonal antibody in vivo2008
- Author(s)
  Mitsunaga M, et.al.
- Organizer
  Digestive Disease Week (DDW)
- Place of Presentation
  San Diego
- Year and Date
  2008-05-20
- Data Source
  KAKENHI-PROJECT-20790512

1. ITO KIMIHIRO (60794336)

# of Collaborated Projects: 3 results

# of Collaborated Products: 10 results
2. IWASE Tadayuki (80385294)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. NISHIMURA TAKASHI

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results

Mitsunaga Makoto 光永 眞人

光永 眞人 ミツナガ マコト

Research Projects

Research Products

Co-Researchers

光反応型エンジニアド分子標的薬による新規病態制御法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

機能性高分子化合物による新規プレシジョンメカノセラピーの開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a theranostic system for abnormal angiogenesisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Nanotheranostic system for cancer with human safety energy devicePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Antibody-selective elimination of drug-resistant pathogens with near-infrared light

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of bacteria-targeted photoimmunotherapyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of molecular-specific cancer theranostics utilizing near-infrared light and monoclonal antibodyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

光線力学療法を併用した新規樹状細胞癌ワクチン療法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Cancer neovasculature-targeted near-infrared photoimmunotherapy (NIR-PIT) for gastric cancer: different mechanisms of phototoxicity compared to cell membrane-targeted NIR-PIT2020

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Photoimmunotherapy targeting biliary‐pancreatic cancer with humanized anti‐TROP2 antibody2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Near-Infrared Photochemoimmunotherapy by Photoactivatable Bifunctional Antibody－Drug Conjugates Targeting Human Epidermal Growth Factor Receptor 2 Positive Cancer2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Combination photoimmunotherapy with monoclonal antibodies recognizing different epitopes of human epidermal growth factor receptor 2: an assessment of phototherapeutic effect based on fluorescence molecular imaging.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Molecular targeted photoimmunotherapy for HER2-positive human gastric cancer in combination with chemotherapy results in improved treatment outcomes through different cytotoxic mechanisms.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] In vitro generation of cytotoxic and regulatory T cells by fusions of human dendritic cells and hepatocellular carcinoma cells2008

Mitsunaga Makoto 光永眞人

光永眞人ミツナガマコト

[Presentation] 光免疫療法　　研究開発から実用化まで2018