Toko Haruhiro 東口治弘

Researcher Number	40436358
Other IDs
Affiliation (Current)	2025: 東京大学, 医学部附属病院, 届出研究員
Affiliation (based on the past Project Information) *help	2021 – 2023: 東京大学, 医学部附属病院, 届出研究員 2018 – 2020: 東京大学, 医学部附属病院, 特任准教授 2016 – 2017: 東京大学, 医学部附属病院, 特任助教 2014 – 2015: 東京大学, 医学部附属病院, 助教
Review Section/Research Field	Principal Investigator Basic Section 53020:Cardiology-related / Basic Section 59040:Nutrition science and health science-related / Cardiovascular medicine Except Principal Investigator Cardiovascular medicine / Basic Section 53020:Cardiology-related / General pharmacology
Keywords	Principal Investigator 心機能 / 炎症 / 脂肪酸代謝 / 心筋梗塞 / Lipin / 脂肪滴 / 脂質代謝 / 心疾患予防食 / 高脂質低炭水化物食 / ステアリン酸 … More / PPARalpha / 動物性脂質 / 植物性脂質 / 高脂質食 / 食事療法 / 食事組成 / 心不全 / 心肥大 / 高脂肪低炭水化物食 … More Except Principal Investigator 心不全 / CXCR7 / リモデリング / 心筋梗塞 / 循環器内科学 / 分子心臓病学 / イメージング解析 / 遺伝子発現 / 心筋細胞 / 精密医療 / バイオインフォマティクス / イメージング / シングルセルRNA-seq / 時空間的遺伝子発現 / シングルセルRNA-seq解析 / 心筋細胞不均一性 / シングルセル生物学 / 不均一性 / シングルセル解析 / 心不全治療薬 / ハイスループットスクリーニング / 選択的阻害剤 / NFAT / 細胞・組織 / 循環器・高血圧 / シグナル伝達 / CXCR7遺伝子欠損マウス Less

脂肪滴形成促進による高脂質食の心保護作用の解明；Lipin1の機能解析Principal Investigator
- Principal Investigator
  
  東口治弘
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  The University of Tokyo
Beta-arrestin-biased agonism of CXCR7 affects post-infarct cardiac remodeling.
- Principal Investigator
  
  Harada Mutsuo
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  The University of Tokyo
The preventive effects of high fat diets for heart diseasesPrincipal Investigator
- Principal Investigator
  
  TOKO HARUHIRO
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  The University of Tokyo
Screening for selective NFATc4 inhibitors to develop a drug of heart failure
- Principal Investigator
  
  Kumagai Hidetoshi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  The University of Tokyo
Cardiomyocyte heterogeneity in heart failure
- Principal Investigator
  
  Komuro Issei
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  The University of Tokyo
The role of CXCR7 in failing heart
- Principal Investigator
  
  Harada Mutsuo
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  The University of Tokyo
The effect of high-fat low-carbon diet on cardiac function and metabolismPrincipal Investigator
- Principal Investigator
  
  Toko Haruhiro
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  The University of Tokyo

All 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014

All Journal Article Presentation

[Journal Article] Low-carbohydrate diets containing plant-derived fat but not animal-derived fat ameliorate heart failure2023
- Author(s)
  Bujo Satoshi、Toko Haruhiro、Ito Kaoru、Koyama Satoshi、Ishizuka Masato、Umei Masahiko、Yanagisawa-Murakami Haruka、Guo Jiaxi、Zhai Bowen、Zhao Chunxia、Kishikawa Risa、Takeda Norifumi、Tsushima Kensuke、Ikeda Yuichi、Takimoto Eiki、Morita Hiroyuki、Harada Mutsuo、Komuro Issei
- Journal Title
  
  Scientific Reports
  
  Volume: 13 Issue: 1 Pages: 3987-3987
- DOI
  10.1038/s41598-023-30821-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08174, KAKENHI-PROJECT-22K16096, KAKENHI-PROJECT-21H02919
[Journal Article] CXCR7 ameliorates myocardial infarction as a β arrestin-biased receptor2021
- Author(s)
  Ishizuka et al.
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 3426-3426
- DOI
  10.1038/s41598-021-83022-5
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08510, KAKENHI-PROJECT-19K11662, KAKENHI-PROJECT-19K17587, KAKENHI-PROJECT-19H03649, KAKENHI-PROJECT-19J13042, KAKENHI-PROJECT-19K17667
[Journal Article] Three-Dimensional Visualization of Hypoxia-Induced Pulmonary Vascular Remodeling in Mice2021
- Author(s)
  Fujiwara Takayuki、Takeda Norifumi、Hara Hironori、Ishii Satoshi、Numata Genri、Tokiwa Hiroyuki、Maemura Sonoko、Suzuki Takaaki、Takiguchi Hiroshi、Kubota Yoshiaki、Seo Kinya、Sakata Asuka、Nomura Seitaro、Hatano Masaru、Ueda Kazutaka、Komuro Issei
- Journal Title
  
  Circulation
  
  Volume: 144 Issue: 17 Pages: 1452-1455
- DOI
  10.1161/circulationaha.121.056219
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08096, KAKENHI-PROJECT-19K11662, KAKENHI-PROJECT-21H04821, KAKENHI-PROJECT-21K16110, KAKENHI-PROJECT-21H05045, KAKENHI-PROJECT-19H03649, KAKENHI-PROJECT-21K08023, KAKENHI-PROJECT-21H02908
[Journal Article] Omega-3 fatty acid prevents the development of heart failure by changing fatty acid composition in the heart2020
- Author(s)
  Toko Haruhiro、Morita Hiroyuki、Katakura Masanori、Hashimoto Michio、Ko Toshiyuki、Bujo Satoshi、Adachi Yusuke、Ueda Kazutaka、Murakami Haruka、Ishizuka Masato、Guo Jiaxi、Zhao Chunxia、Fujiwara Takayuki、Hara Hironori、Takeda Norifumi、Takimoto Eiki、Shido Osamu、Harada Mutsuo、Komuro Issei
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 15553-15553
- DOI
  10.1038/s41598-020-72686-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K11662, KAKENHI-PROJECT-19K17587, KAKENHI-PROJECT-19K17667
[Journal Article] Estrogen Receptor-α Non-Nuclear Signaling Confers Cardioprotection and?Is?Essential to cGMP-PDE5 Inhibition?Efficacy2020
- Author(s)
  Fukuma Nobuaki、Takimoto Eiki、Ueda Kazutaka、Liu Pangyen、Tajima Miyu、Otsu Yu、Kariya Taro、Harada Mutsuo、Toko Haruhiro、Koga Kaori、Blanton Robert M.、Karas Richard H.、Komuro Issei
- Journal Title
  
  JACC: Basic to Translational Science
  
  Volume: 5 Issue: 3 Pages: 282-295
- DOI
  10.1016/j.jacbts.2019.12.009
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K11662, KAKENHI-PROJECT-17H01560, KAKENHI-PROJECT-18K08096
[Journal Article] Cardiac dopamine D1 receptor triggers ventricular arrhythmia in chronic heart failure2020
- Author(s)
  Yamaguchi Toshihiro、Sumida Tomokazu S.、Nomura Seitaro、Satoh Masahiro、Higo Tomoaki、Ito Masamichi、Ko Toshiyuki、Fujita Kanna、Sweet Mary E.、Sanbe Atsushi、Yoshimi Kenji、Manabe Ichiro、Sasaoka Toshikuni、Taylor Matthew R. G.、Toko Haruhiro、Takimoto Eiki、Naito Atsuhiko T.、Komuro Issei
- Journal Title
  
  Nature Communications
  
  Volume: 11 Issue: 1 Pages: 4364-4364
- DOI
  10.1038/s41467-020-18128-x
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K11662, KAKENHI-PROJECT-19K17587, KAKENHI-PROJECT-18H02540, KAKENHI-PROJECT-19H03649, KAKENHI-PROJECT-19H03662, KAKENHI-PROJECT-18K15881
[Journal Article] Inhibition of transforming growth factor-β signaling in myeloid cells ameliorates aortic aneurysmal formation in Marfan syndrome2020
- Author(s)
  Hara Hironori、Maemura Sonoko、Fujiwara Takayuki、Takeda Norifumi、Ishii Satoshi、Yagi Hiroki、Suzuki Takaaki、Harada Mutsuo、Toko Haruhiro、Kanaya Tsubasa、Ijichi Hideaki、Moses Harold L.、Takimoto Eiki、Morita Hiroyuki、Akazawa Hiroshi、Komuro Issei
- Journal Title
  
  PLOS ONE
  
  Volume: 15 Issue: 11 Pages: e0239908-e0239908
- DOI
  10.1371/journal.pone.0239908
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08484, KAKENHI-PROJECT-19K11662, KAKENHI-PROJECT-18K08097, KAKENHI-PROJECT-19K17667
[Journal Article] Overview of the 83<sup>rd</sup> Annual Scientific Meeting of the Japanese Circulation Society　― Renaissance of Cardiology for the Creation of Future Medicine ―2019
- Author(s)
  Akazawa H, Toko H, Harada M, Ueda K, Kodera S, Kiyosue A, Fujiu K, Hatano M, Daimon M, Ando J, Takimoto E, Morita H, Komuro I
- Journal Title
  
  Circ J
  
  Volume: 83 Issue: 9 Pages: 1829-1835
- DOI
  10.1253/circj.CJ-19-0587
- NAID
  130007695023
- ISSN
  1346-9843, 1347-4820
- Year and Date
  2019-08-23
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08097, KAKENHI-PROJECT-17H01560, KAKENHI-PROJECT-18K08096
[Journal Article] Short-Term and Long-Term Efficacy of Drug-Coated Balloon for In-Stent Restenosis in Hemodialysis Patients with Coronary Artery Disease2019
- Author(s)
  Kiriyama H, Kodera S
- Journal Title
  
  Int. Heart J.
  
  Volume: 60 Issue: 5 Pages: 1070-1076
- DOI
  10.1536/ihj.18-533
- NAID
  130007719014
- ISSN
  1349-2365, 1349-3299
- Year and Date
  2019-09-27
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K10479, KAKENHI-PROJECT-19K11662
[Journal Article] High-throughput single-molecule RNA imaging analysis reveals heterogeneous responses of cardiomyocytes to hemodynamic overload2019
- Author(s)
  Satoh M、Nomura S、Harada M、Yamaguchi T、Ko T、Sumida T、Toko H、Naito AT.、Takeda N、Tobita T、Fujita T、Ito M、Fujita K、Ishizuka M、Kariya T、Akazawa H、Kobayashi Y、Morita H、Takimoto E、Aburatani H、Komuro I
- Journal Title
  
  Journal of Molecular and Cellular Cardiology
  
  Volume: 128 Pages: 77-89
- DOI
  10.1016/j.yjmcc.2018.12.018
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06566, KAKENHI-PROJECT-17H01560, KAKENHI-PROJECT-19H03649, KAKENHI-PROJECT-18K08097
[Journal Article] Endothelial Cell?Derived Angiocrines Elicit Physiological Cardiomyocyte Hypertrophy2019
- Author(s)
  Ueda Kazutaka、Toko Haruhiro、Komuro Issei
- Journal Title
  
  Circulation
  
  Volume: 139 Issue: 22 Pages: 2585-2587
- DOI
  10.1161/circulationaha.119.040632
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K11662, KAKENHI-PROJECT-17H01560, KAKENHI-PROJECT-18K08096
[Journal Article] Genetic basis of cardiomyopathy and the genotypes involved in prognosis and left ventricular reverse remodeling2018
- Author(s)
  Tobita T, Nomura S, Fujita T, Morita H, Asano Y, Onoue K, Ito M, Imai Y, Suzuki A, Ko T, Satoh M, Fujita K, Naito AT, Furutani Y, Toko H, Harada M, Amiya E, Hatano M, Takimoto E, Shiga T, Nakanishi T, Sakata Y, Ono M, Saito Y, Takashima S, Hagiwara N, Aburatani H, Komuro I.
- Journal Title
  
  Sci Rep
  
  Volume: 8 Issue: 1 Pages: 20114-20119
- DOI
  10.1038/s41598-018-20114-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09129, KAKENHI-PROJECT-15H04806, KAKENHI-PROJECT-15H04820, KAKENHI-PROJECT-17H04061, KAKENHI-PROJECT-17J00085, KAKENHI-PROJECT-17J05937, KAKENHI-PROJECT-15K21388, KAKENHI-PROJECT-17H06566, KAKENHI-PROJECT-17H01560, KAKENHI-PROJECT-15K09139
[Journal Article] Discovery of a Small Molecule to Increase Cardiomyocytes and Protect the Heart After Ischemic Injury2018
- Author(s)
  Hara H, Takeda N, Kondo M, Kubota M, Saito T, Maruyama J, Fujiwara T, Maemura S, Ito M, Naito AT, Harada M, Toko H, Nomura S, Kumagai H, Ikeda Y, Ueno H, Takimoto E, Akazawa H, Morita H, Aburatani H, Hata Y, Uchiyama M, Komuro I.
- Journal Title
  
  JACC: Basic to Translational Science
  
  Volume: 3 Issue: 5 Pages: 639-653
- DOI
  10.1016/j.jacbts.2018.07.005
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08585, KAKENHI-PROJECT-18K06571, KAKENHI-PUBLICLY-18H05105, KAKENHI-PROJECT-17J05193, KAKENHI-PROJECT-17K19673, KAKENHI-PROJECT-17K15987, KAKENHI-PROJECT-19K07948, KAKENHI-PROJECT-18K08097
[Journal Article] Cardiomyocyte gene programs encoding morphological and functional signatures in cardiac hypertrophy and failure.2018
- Author(s)
  Nomura S, Satoh M, Fujita T, Higo T, Sumida T, Ko T, Yamaguchi T, Tobita T, Naito AT, Ito M, Fujita K, Harada M, Toko H, Kobayashi Y, Ito K, Takimoto E, Akazawa H, Morita H, Aburatani H, Komuro I.
- Journal Title
  
  Nat Commun.
  
  Volume: 9 Issue: 1 Pages: 4435-4435
- DOI
  10.1038/s41467-018-06639-7
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H01560, KAKENHI-PROJECT-16H04726, KAKENHI-PROJECT-17H04061, KAKENHI-PROJECT-17H06566, KAKENHI-PROJECT-18K08097
[Journal Article] Distinct variants affecting differential splicing of TGFBR1 exon 5 cause either Loeys?Dietz syndrome or multiple self-healing squamous epithelioma2018
- Author(s)
  Fujiwara Takayuki、Takeda Norifumi、Hara Hironori、Morita Hiroyuki、Kishihara Jun、Inuzuka Ryo、Yagi Hiroki、Maemura Sonoko、Toko Haruhiro、Harada Mutsuo、Ikeda Yuichi、Kumagai Hidetoshi、Nomura Seitaro、Takimoto Eiki、Akazawa Hiroshi、Ako Junya、Komuro Issei
- Journal Title
  
  European Journal of Human Genetics
  
  Volume: 26 Issue: 8 Pages: 1151-1158
- DOI
  10.1038/s41431-018-0127-1
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08585, KAKENHI-PROJECT-17J05193, KAKENHI-PROJECT-16K10059, KAKENHI-PROJECT-17K19673, KAKENHI-PROJECT-18K08097
[Journal Article] Prostaglandin E2 Signaling as a Target of Anti-Cardiac Fibrosis in Heart Failure Treatment2017
- Author(s)
  Harada M, Takeda N, Toko H.
- Journal Title
  
  Int. Heart J.
  
  Volume: 58 Issue: 1 Pages: 3-4
- DOI
  10.1536/ihj.16-614
- NAID
  130005330498
- ISSN
  1349-2365, 1349-3299
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461124, KAKENHI-PROJECT-15K09132, KAKENHI-PROJECT-16K09492
[Journal Article] Dysbiosis and compositional alterations with aging in the gut microbiota of patients with heart failure.2017
- Author(s)
  Kamo T, Akazawa H, Suda W, Saga-Kamo A, Shimizu Y, Yagi H, Liu Q, Nomura S, Naito AT, Takeda N, Harada M, Toko H, Kumagai H, Ikeda Y, Takimoto E, Suzuki JI, Honda K, Morita H, Hattori M, Komuro I.
- Journal Title
  
  PLoS One.
  
  Volume: 12 Issue: 3 Pages: 0174099-0174099
- DOI
  10.1371/journal.pone.0174099
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26253049, KAKENHI-PROJECT-26460333, KAKENHI-PROJECT-26461124, KAKENHI-PROJECT-15K19371, KAKENHI-PROJECT-15K09132, KAKENHI-PROJECT-17K08585, KAKENHI-PROJECT-17K19673, KAKENHI-PROJECT-17K15989, KAKENHI-PROJECT-15H04806, KAKENHI-PROJECT-16K15199, KAKENHI-PROJECT-17H01560
[Journal Article] Identification of MYLK3 mutations in familial dilated cardiomyopathy2017
- Author(s)
  Tobita Takashige、Nomura Seitaro、Morita Hiroyuki、Ko Toshiyuki、Fujita Takanori、Toko Haruhiro、Uto Kenta、Hagiwara Nobuhisa、Aburatani Hiroyuki、Komuro Issei
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Issue: 1 Pages: 17495-17495
- DOI
  10.1038/s41598-017-17769-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H04806, KAKENHI-PROJECT-17H04061, KAKENHI-PROJECT-17J00085, KAKENHI-PROJECT-17J05937, KAKENHI-PROJECT-16K15199, KAKENHI-PROJECT-17H01560
[Journal Article] Pathophysiology and Management of Cardiovascular Manifestations in Marfan and Loeys–Dietz Syndromes2016
- Author(s)
  Takeda N, Yagi H, Hara H, Fujiwara T, Fujita D, Nawata K, Inuzuka R, Taniguchi Y, Harada M, Toko H, Akazawa H, Komuro I.
- Journal Title
  
  Int. Heart J.
  
  Volume: 57 Issue: 3 Pages: 271-277
- DOI
  10.1536/ihj.16-094
- NAID
  130005153709
- ISSN
  1349-2365, 1349-3299
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15J00378, KAKENHI-PROJECT-26461124, KAKENHI-PROJECT-15K09132
[Journal Article] Does Mechanical Stress Regulate the Angiogenic Profile of Endothelial Progenitor Cells?2016
- Author(s)
  Harada M, Toko H.
- Journal Title
  
  Int Heart J
  
  Volume: 57 Pages: 268-268
- NAID
  130005153710
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09492
[Journal Article] S100A4 protects the myocardium against ischemic stress.2016
- Author(s)
  Doroudgar S, Quijada P, Konstandin M, Ilves K, Broughton K, Khalafalla FG, Casillas A, Nguyen K, Gude N, Toko H, Ornelas L, Thuerauf DJ, Glembotski CC, Sussman MA, Volkers M.
- Journal Title
  
  J Mol Cell Cardiol.
  
  Volume: 100 Pages: 54-63
- DOI
  10.1016/j.yjmcc.2016.10.001
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461124
[Journal Article] Does Mechanical Stress Regulate the Angiogenic Profile of Endothelial Progenitor Cells?2016
- Author(s)
  Harada M, Toko H.
- Journal Title
  
  Int. Heart J.
  
  Volume: 57 Issue: 3 Pages: 268-270
- DOI
  10.1536/ihj.16-168
- NAID
  130005153710
- ISSN
  1349-2365, 1349-3299
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26461124
[Journal Article] Deletion of low molecular weight protein tyrosine phosphatase (Acp1) protects against stress-induced cardiomyopathy.2015
- Author(s)
  Wade F, Quijada P, Al-Haffar KM, Awad SM, Kunhi M, Toko H, Marashly Q, Belhaj K, Zahid I, Al-Mohanna F, Stanford SM, Alvarez R, Liu Y, Colak D, Jordan MC, Roos KP, Assiri A, Al-Habeeb W, Sussman M, Bottini N, Poizat C.
- Journal Title
  
  J Pathol
  
  Volume: 237 Issue: 4 Pages: 482-94
- DOI
  10.1002/path.4594
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461124
[Journal Article] Notch activation enhances lineage commitment and protective signaling in cardiac progenitor cells.2015
- Author(s)
  Gude N, Joyo E, Toko H, Quijada P, Villanueva M, Hariharan N, Sacchi V, Truffa S, Joyo A, Voelkers M, Alvarez R, Sussman MA.
- Journal Title
  
  Basic Res Cardiol
  
  Volume: 110 Issue: 3
- DOI
  10.1007/s00395-015-0488-3
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461124
[Journal Article] Monitoring beta-arrestin recruitment via beta-lactamase enzyme fragment complementation: purification of peptide E as a low-affinity ligand for mammalian bombesin receptors2015
- Author(s)
  Ikeda Y*, Kumagai H*, Okazaki H, Fujishiro M, Motozawa Y, Nomura S, Takeda N, Toko H, Takimoto E, Akazawa H, Morita H, Suzuki J, Yamazaki T, Komuro I, Yanagisawa M (co-first author)
- Journal Title
  
  PLoS One
  
  Volume: 10 Issue: 6 Pages: e0127445-e0127445
- DOI
  10.1371/journal.pone.0127445
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26460333, KAKENHI-PROJECT-26461124, KAKENHI-PROJECT-15K19371, KAKENHI-PROJECT-26253049, KAKENHI-PROJECT-15H04806, KAKENHI-PROJECT-15K15047, KAKENHI-PROJECT-26670395
[Journal Article] Quantitative measurement of GPCR endocytosis via pulse-chase covalent labeling2015
- Author(s)
  Kumagai H, Ikeda Y, Motozawa Y, Fujishiro M, Okamura T, Fujio K, Okazaki H, Nomura S, Takeda N, Harada M, Toko H, Takimoto E, Akazawa H, Morita H, Suzuki J, Yamazaki T, Yamamoto K, Komuro I, Yanagisawa M
- Journal Title
  
  PLoS One
  
  Volume: 10 Issue: 5 Pages: e0129394-e0129394
- DOI
  10.1371/journal.pone.0129394
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26460333, KAKENHI-PROJECT-26461124, KAKENHI-PROJECT-15K19371, KAKENHI-PROJECT-26253049, KAKENHI-PROJECT-15H04806, KAKENHI-PROJECT-15K15047, KAKENHI-PROJECT-26670395
[Journal Article] Cardiac progenitor cells engineered with βARKct have enhanced β-adrenergic tolerance2014
- Author(s)
  Khan M, Mohsin S, Toko H, Alkatib M, Nguyen J, Truffa S, Gude N, Chuprun K, Tilley DG, Koch WJ, Sussman MA
- Journal Title
  
  Mol Ther
  
  Volume: 22 Issue: 1 Pages: 178-185
- DOI
  10.1038/mt.2013.200
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26461124
[Journal Article] Metabolic dysfunction consistent with premature aging results from deletion of Pim kinases2014
- Author(s)
  Din S, Konstandin MH, Johnson B, Emathinger J, Volkers M, Toko H, Collins B, Ormachea L, Samse K, Kubli DA, De La Torre A, Kraft AS, Gustafsson AB, Kelly DP, Sussman MA.
- Journal Title
  
  Circ Res
  
  Volume: 115 Issue: 3 Pages: 376-387
- DOI
  10.1161/circresaha.115.304441
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26461124
[Journal Article] Differential regulation of cellular senescence and differentiation by prolyl isomerase Pin1 in cardiac progenitor cells2014
- Author(s)
  Toko H, Hariharan N, Konstandin MH, Ormachea L, McGregor M, Gude NA, Sundararaman B, Joyo E, Joyo AY, Collins B, Din S, Mohsin S, Uchida T, Sussman MA
- Journal Title
  
  J Biol Chem
  
  Volume: 289 Issue: 9 Pages: 5348-5356
- DOI
  10.1074/jbc.m113.526442
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26461124
[Presentation] Lipin1 Protects the Heart against Ischemic Damage through Regulating Lipid Metabolism in Myocardium2023
- Author(s)
  Guo J, Ueda K, Toko H, Harada M, Bujo S, Ishizuka M, Adachi A, Hashimoto M, Komuro I.
- Organizer
  Annual Scientific Meeting of Japanese Circulation Society
- Data Source
  KAKENHI-PROJECT-22K08174
[Presentation] Plant-based Low Carbohydrate Diet Mitigates the Progression of Experimental Murine Abdominal Aortic Aneurysm2022
- Author(s)
  翟博文、東口治弘、趙春霞、武城怜史、石塚理人、郭嘉熙、岸川理紗、安達裕助、大谷明、橋本昌樹、上田和孝、原田睦生、小室一成
- Organizer
  第86回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-19K11662
[Presentation] Lipin1, a Regulator of Lipid Homeostasis, Protects Heart against Ischemic Injury.2022
- Author(s)
  Guo J, Toko H, Harada M, Ishizuka M, Adachi A, Bujo S, Otani A, Hashimoto M, Kishikawa R, Zhai B, Ueda K, Komuro I.
- Organizer
  Annual Scientific Meeting of Japanese Circulation Society
- Data Source
  KAKENHI-PROJECT-22K08174
[Presentation] Lipin1 prevents ischemic heart disease by regulating lipid homeostasis.2022
- Author(s)
  Guo J, Ueda K, Bujo S, Ishizuka M, Adachi A, Hashimoto M, Harada M, Toko H, Komuro I.
- Organizer
  日本循環器学会基礎研究フォーラム(BCVR)
- Data Source
  KAKENHI-PROJECT-22K08174
[Presentation] Lipin1, a regulator of lipid homeostasis, protects heart against ischemic injury2022
- Author(s)
  Jiaxi Guo, Haruhiro Toko, Kazutaka Ueda, Masato Ishizuka, Yusuke Adachi, Satoshi Bujo, Akira Otani, MasakiHasimoto, Risa Kishikawa, Bowen Zhai, Mutsuo Harada, Issei Komuro
- Organizer
  第86回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-19K11662
[Presentation] Lipin1 protects against ischemic heart diseases by regulating lipid homeostasis.2022
- Author(s)
  Guo J, Toko H, Harada M, Ishizuka M, Adachi A, Bujo S, Otani A, Hashimoto M, Sowa H, Kishikawa R, Zhai B, Ueda K, Komuro I.
- Organizer
  日本心不全学会学術集会
- Data Source
  KAKENHI-PROJECT-22K08174
[Presentation] 高植物性脂質低炭水化物食は転写因子PPARαを活性化し心保護に働く2021
- Author(s)
  武城怜史、東口治弘、伊藤薫、石塚理人、梅井正彦、郭嘉熙、翟博文、岸川理紗、原田睦生、小室一成
- Organizer
  第25回日本心血管内分泌代謝学会学術総会
- Data Source
  KAKENHI-PROJECT-19K11662
[Presentation] 高植物性脂質食は転写因子PPARα活性化により心不全を抑制する -脂質組成が心不全に与える影響の機序解明-2021
- Author(s)
  武城怜史、東口治弘、伊藤薫、石塚理人、梅井正彦、岸川理紗、原田睦生、小室一成
- Organizer
  第262回日本循環器学会関東甲信越地方会
- Data Source
  KAKENHI-PROJECT-19K11662
[Presentation] Cardioprotective Effects of Plant-derived Fat in Low Carbohydrate Diet on the Progression of Heart Failure2019
- Author(s)
  Satoshi Bujo, Haruhiro Toko, Mutsuo Harada, Jiaxi Guo, Masato Ishizuka, Haruka Yanagisawa, Issei Komuro
- Organizer
  BCVS (Basic Cardiovascular Sciences) Scientific Sessions
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K11662
[Presentation] 低炭水化物高脂質食による血管障害後血管リモデリングへの影響2019
- Author(s)
  柳沢遙香、東口治弘、郭嘉熙、武城怜史、石塚理人、原田睦生、小室一成
- Organizer
  第73回　日本栄養・食糧学会大会
- Data Source
  KAKENHI-PROJECT-19K11662
[Presentation] Opposing effects of fat sources in low carbohydrate diet on the progression of heart failure2019
- Author(s)
  Satoshi Bujo, Haruhiro Toko, Mutsuo Harada, Jiaxi Guo, Masato Ishizuka, Haruka Yanagisawa, Issei Komuro
- Organizer
  ISHR (International Society for Heart Research)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K11662
[Presentation] 低炭水化物高脂質食が心肥大・心不全に及ぼす影響2019
- Author(s)
  武城怜史、東口治弘、郭嘉熙、柳沢遙香、石塚理人、原田睦生、小室一成
- Organizer
  第73回　日本栄養・食糧学会大会
- Data Source
  KAKENHI-PROJECT-19K11662
[Presentation] The effects of low-carbohydrate high-fat diet on vascular remodeling2019
- Author(s)
  Haruka Yanagisawa-Murakami, Haruhiro Toko, Masato Ishizuka, Mutsuo Harada, Jiaxi Guo, Satoshi Bujo, Issei Komuro
- Organizer
  BCVS (Basic Cardiovascular Sciences) Scientific Sessions
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K11662
[Presentation] 低炭水化物高脂肪食は拡張型心筋症の心機能低下を抑制する2016
- Author(s)
  東口治弘
- Organizer
  日本心筋症研究会
- Place of Presentation
  まつもと市民芸術館（長野県松本市）
- Data Source
  KAKENHI-PROJECT-26461124

1. Harada Mutsuo (90431642)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
2. Kumagai Hidetoshi (20281008)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
3. 池田祐一 (10744419)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
4. Komuro Issei (30260483)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
5. 野村征太郎 (10722118)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
6. 波多野将 (20456130)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. KO Toshiyuki

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
8. MURAKAMI Haruka

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. ISHIZUKA Masato

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. HAGIWARA nobuhisa

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. SHIGA tsuyoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 内藤篤彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 佐藤加代子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 鈴木敦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 佐藤真洋

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 柳沢正史

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
17. 森田啓行

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 武田憲文

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 上田和孝

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Toko Haruhiro 東口 治弘

Research Projects

Research Products

Co-Researchers

脂肪滴形成促進による高脂質食の心保護作用の解明；Lipin1の機能解析Principal Investigator

Principal Investigator

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Beta-arrestin-biased agonism of CXCR7 affects post-infarct cardiac remodeling.

Principal Investigator

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The preventive effects of high fat diets for heart diseasesPrincipal Investigator

Principal Investigator

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Review Section

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Screening for selective NFATc4 inhibitors to develop a drug of heart failure

Principal Investigator

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Cardiomyocyte heterogeneity in heart failure

Principal Investigator

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The role of CXCR7 in failing heart

Principal Investigator

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The effect of high-fat low-carbon diet on cardiac function and metabolismPrincipal Investigator

Principal Investigator

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Research Institution

[Journal Article] Low-carbohydrate diets containing plant-derived fat but not animal-derived fat ameliorate heart failure2023

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[Journal Article] CXCR7 ameliorates myocardial infarction as a β arrestin-biased receptor2021

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[Journal Article] Three-Dimensional Visualization of Hypoxia-Induced Pulmonary Vascular Remodeling in Mice2021

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[Journal Article] Omega-3 fatty acid prevents the development of heart failure by changing fatty acid composition in the heart2020

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[Journal Article] Estrogen Receptor-α Non-Nuclear Signaling Confers Cardioprotection and?Is?Essential to cGMP-PDE5 Inhibition?Efficacy2020

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[Journal Article] Cardiac dopamine D1 receptor triggers ventricular arrhythmia in chronic heart failure2020

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[Journal Article] Inhibition of transforming growth factor-β signaling in myeloid cells ameliorates aortic aneurysmal formation in Marfan syndrome2020

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DOI

Toko Haruhiro 東口治弘

[Journal Article] Overview of the 83<sup>rd</sup> Annual Scientific Meeting of the Japanese Circulation Society　― Renaissance of Cardiology for the Creation of Future Medicine ―2019