KAWAI Nobuhiko 川合暢彦

Researcher Number	40437588
Other IDs
Affiliation (based on the past Project Information) *help	2018 – 2019: 徳島大学, 大学院医歯薬学研究部(歯学域), 講師 2017: 徳島大学, 大学院医歯薬学研究部(歯学系), 講師 2016: 徳島大学, 大学院医歯薬学研究部(歯学系), 助教 2015: 徳島大学, 大学院医歯薬学研究部, 助教 2012 – 2014: 徳島大学, ヘルスバイオサイエンス研究部, 助教 … More 2009 – 2011: 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 助教 2008: Hiroshima University, 大学院・医歯薬学総合研究科, 助教 2007: Hiroshima University, 病院, 歯科診療医 Less
Review Section/Research Field	Principal Investigator Orthodontic/Pediatric dentistry / Orthodontics/Pediatric dentistry Except Principal Investigator Orthodontic/Pediatric dentistry / Orthodontics/Pediatric dentistry
Keywords	Principal Investigator 機能性ペプチド / Cbl-b / ユビキチン-プロテアソーム経路 / IGF-1シグナル / 骨格筋萎縮 / ユビキチンン-プロテアソーム経路 / 筋電図 / 咀嚼筋 / 蛋白質 / シグナル伝達 … More / 歯学 / RNA干渉 / マイオスタチン / 筋ジストロフィー / リモデリング / 下顎骨 / 咀嚼 … More Except Principal Investigator siRNA / 瘢痕形成 / Smad3 / 口蓋粘膜 / 創傷治癒 / リポソーム / 骨格筋 / RNAi / Smad3拮抗薬 / 歯科矯正学 Less

ユビキチン-プロテアソーム系制御による廃用性筋萎縮抑制法の開発Principal Investigator
- Principal Investigator
  
  川合暢彦
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthodontics/Pediatric dentistry
- Research Institution
  The University of Tokushima
Development of the treatment of the skeletal muscle atrophy through the IGF-1 signaling in the growth periodPrincipal Investigator
- Principal Investigator
  
  KAWAI Nobuhiko
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthodontics/Pediatric dentistry
- Research Institution
  The University of Tokushima
Development study of the nucleic acid innovative drug development for the chronic amyotrophy-related disease
- Principal Investigator
  
  KINOUCHI Nao
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthodontics/Pediatric dentistry
- Research Institution
  The University of Tokushima
Development of the inhibition of skeletal muscle atrophy with anti-ubiquitination oligopeptidePrincipal Investigator
- Principal Investigator
  
  KAWAI Nobuhiko
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Orthodontic/Pediatric dentistry
- Research Institution
  The University of Tokushima
口蓋形成術後の瘢痕形成抑制を目指した次世代RNA医薬品の開発
- Principal Investigator
  
  内田玲子
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthodontic/Pediatric dentistry
- Research Institution
  The University of Tokushima
The mechanism of the myofunctional recovery using RNA interference aiming at the treatment of the skeletal muscle disorderPrincipal Investigator
- Principal Investigator
  
  KAWAI Nobuhiko
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Orthodontic/Pediatric dentistry
- Research Institution
  The University of Tokushima
Novel therapy to prevent scar formation in wound healing via TGF-β/Smad3 signaling pathway
- Principal Investigator
  
  TANAKA Eiji
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthodontic/Pediatric dentistry
- Research Institution
  The University of Tokushima
食物の物性により異なる咀嚼性刺激が顎骨および咀嚼筋の成長発育に及ぼす影響Principal Investigator
- Principal Investigator
  
  川合暢彦
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (Start-up)
- Research Field
  
  Orthodontic/Pediatric dentistry
- Research Institution
  Hiroshima University

All 2019 2018 2017 2016 2015 2013 2011 2010 2008 Other

All Journal Article Presentation

[Journal Article] Effects of gum chewing exercise on maximum bite force according to facial morphology.2018
- Author(s)
  Manami Shirai, Nobuhiko Kawai, Natsuko Hichijo, Masahiko Watanabe, Hiroyo Mori, Silvia Naomi Mitsui, Akihiro Yasue, Eiji Tanaka
- Journal Title
  
  Clinical and Experimental Dental Research
  
  Volume: 4 Issue: 2 Pages: 48-51
- DOI
  10.1002/cre2.102
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K11938, KAKENHI-PROJECT-16H07016
[Journal Article] Effects of Co-Transfection with Myostatin-Targeting siRNA and ActRIIB-Fc Fusion Protein on Skeletal Muscle Growth2017
- Author(s)
  Bayarsaikhan O, Kawai N, Mori H, Kinouchi N, Nikawa T, Tanaka E
- Journal Title
  
  Journal of Oral Health and Biosciences
  
  Volume: 印刷中
- NAID
  130007053969
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26463095
[Journal Article] Co-administration of myostatin-targeting siRNA and ActRIIB-Fc fusion protein increases masseter muscle mass and fiber size2017
- Author(s)
  Bayarsaikhan O, Kawai N, Mori H, Kinouchi N, Nikawa T, Tanaka E
- Journal Title
  
  Journal of Nutritional Science and Vitaminology
  
  Volume: 印刷中
- NAID
  130007314434
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26463095
[Journal Article] Prevention of skeletal muscle atrophy in vitro using anti-ubiquitination oligopeptide carried by atelocollagen2015
- Author(s)
  Kawai N, Hirasaka K, Maeda T, Haruna M, Shiota C, Ochi A, Abe T, Kohno S, Ohno A, Teshima-Kondo S Mori H, Tanaka E, Nikawa T
- Journal Title
  
  Biochim Biophys Acta Molecular Cell Research
  
  Volume: 1853 Issue: 5 Pages: 873-880
- DOI
  10.1016/j.bbamcr.2015.01.024
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24390355, KAKENHI-PROJECT-26350148, KAKENHI-PROJECT-26463095, KAKENHI-PROJECT-15H04931
[Journal Article] Effects of Decreased Occlusal Loading during Growth on the Mandibular Bone Characteristics2015
- Author(s)
  Hichijo N, Tanaka E, Kawai N, van Ruijven LJ, Langenbach GE
- Journal Title
  
  PLoS One
  
  Volume: 10
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26463095
[Journal Article] Flavones Inhibit LPS-Induced Atrogin-1/MAFbx Expression in Mouse C2C12 Skeletal Myotubes2015
- Author(s)
  Shiota C, Abe T, Kawai N, Ohno A, Teshima-Kondo S, Mori H, Terao J, Tanaka E, Nikawa T
- Journal Title
  
  J Nutr Sci Vitaminol (Tokyo)
  
  Volume: 61 Issue: 2 Pages: 188-194
- DOI
  10.3177/jnsv.61.188
- NAID
  130005074121
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26463095, KAKENHI-PROJECT-15H04960
[Journal Article] Changes in activity and structure of jaw muscles in Parkinson's disease model rats2013
- Author(s)
  Nakamura S, Kawai N, Ohnuki Y, Saeki Y, Korfage JA, Langenbach GE, Kitayama T, Watanabe M, Sano R, Tanne K, Tanaka E
- Journal Title
  
  Journal of Oral Rehabilitation
  
  Volume: 40 Issue: 3 Pages: 205-213
- DOI
  10.1111/joor.12030
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24792289
[Journal Article] Local Applications of Myostatin-siRNA with Atelocollagen Increse Skeletal Muscle Mass and Recovery of Muscle Function2013
- Author(s)
  Kawakami E, Kawai N, Kinouchi N, Mori H, Ohsawa Y, Ishimaru N, Sunada Y, Noji S, Tanaka E
- Journal Title
  
  PLoS One
  
  Volume: 8 Issue: 5 Pages: e64719-e64719
- DOI
  10.1371/journal.pone.0064719
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591281, KAKENHI-PROJECT-24792289
[Journal Article] Adaptation of rat jaw muscle fibers in postnatal development with a different food consistency : an immunohistochemical and electromyographic study2010
- Author(s)
  Kawai N, Sano R, Korfage JAM, Nakamura S, Kinouchi N, Kawakami E, Tanne K, Langenbach GEJ, Tanaka E.
- Journal Title
  
  Journal of Anatomy
  
  Volume: 216 Issue: 6 Pages: 717-723
- DOI
  10.1111/j.1469-7580.2010.01235.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22792055
[Journal Article] Adaptation of rat jaw muscle fibers in postnatal development with a different food consistency : an immunohistochemical and electromyographic study.2010
- Author(s)
  Nobuhiko Kawai, et al
- Journal Title
  
  Journal of Anatomy
  
  Volume: 216 Pages: 717-723
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22792055
[Journal Article] Jaw-muscle activity changes after the induction of osteoarthrosis in the temporomandibular joint by mechanical loading.2008
- Author(s)
  Nobuhiko Kawai
- Journal Title
  
  Journal of Orofacial Pain 22
  
  Pages: 153-162
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19890138
[Presentation] 顎矯正手術後の咀嚼訓練の実践2019
- Author(s)
  川合暢彦
- Organizer
  第29回特定非営利活動法人日本顎変形症学会総会・学術大会公
- Data Source
  KAKENHI-PROJECT-17K11938
[Presentation] 外科的矯正治療と矯正単独治療を行った骨格性下顎前突症患者の顎口腔機能評価2018
- Author(s)
  渡邊正彦, 川合暢彦, 白井愛実, 七條なつ子, 三井なおみ, 泰江章博, 田中栄二
- Organizer
  第61回中・四国矯正歯科学会大会
- Data Source
  KAKENHI-PROJECT-17K11938
[Presentation] 顎変形症患者への顎矯正手術後のリハビリテーション2017
- Author(s)
  川合暢彦
- Organizer
  第27回日本顎変形症学会総会・学術大会
- Data Source
  KAKENHI-PROJECT-17K11938
[Presentation] 抗ユビキチン化ペプチドによる骨格筋萎縮抑制2016
- Author(s)
  川合暢彦, 二川健, 田中栄二
- Organizer
  第4回骨格筋生物学研究会
- Place of Presentation
  長野県松本市：松本大学
- Year and Date
  2016-03-04
- Data Source
  KAKENHI-PROJECT-26463095
[Presentation] 骨格筋萎縮におけるユビキチンリガーゼCbl-bの役割2015
- Author(s)
  川合暢彦
- Organizer
  「筋ジストロフィー関連疾患の基盤的診断・治療開発研究」(26-8) 西野班班会議
- Place of Presentation
  東京都小平市：国立精神・神経医療研究センター
- Year and Date
  2015-12-06
- Data Source
  KAKENHI-PROJECT-26463095
[Presentation] 抗ユビキチン化ペプチドによる骨格筋萎縮抑制法の開発2013
- Author(s)
  川合暢彦, 平坂勝也, 七條なつ子, 塩田智子, 森博世, 木内奈央, 二川健, 田中栄二
- Organizer
  第72回日本矯正歯科学会大会
- Place of Presentation
  キッセイ文化ホール (長野県)
- Data Source
  KAKENHI-PROJECT-24792289
[Presentation] アテロコラーゲンを担体とした抗ユビキチン化ペプチドによる骨格筋萎縮抑制2013
- Author(s)
  川合暢彦, 平坂勝也, 塩田智子, 越智ありさ, 安倍知紀, 真板綾子, 近藤茂忠, 田中栄二 , 二川健
- Organizer
  日本宇宙生物科学会・第27回大会
- Place of Presentation
  茨城県. つくば市
- Data Source
  KAKENHI-PROJECT-24792289
[Presentation] 抗ユビキチン化ペプチドによる骨格筋萎縮抑制法の開発2013
- Author(s)
  川合暢彦, 平坂勝也, 七條なつ子, 塩田智子, 森博世, 木内奈央, 二川健, 田中栄二
- Organizer
  第72回日本矯正歯科学会大会
- Place of Presentation
  長野県. 松本市
- Data Source
  KAKENHI-PROJECT-24792289
[Presentation] アテロコラーゲンを担体とした抗ユビキチン化ペプチドによる骨格筋萎縮抑制2013
- Author(s)
  川合暢彦, 平坂勝也, 塩田智子, 越智ありさ, 安倍知紀, 真板綾子, 近藤茂忠, 田中栄二 , 二川健
- Organizer
  日本宇宙生物科学会・第27回大会
- Place of Presentation
  筑波大学 (茨城県)
- Data Source
  KAKENHI-PROJECT-24792289
[Presentation] 筋ジストロフィーモデルマウスにおけるRNA干渉を用いた咀嚼筋機能の回復2011
- Author(s)
  川合暢彦
- Organizer
  日本顎口腔機能学会
- Place of Presentation
  兵庫医療大学(兵庫県)
- Year and Date
  2011-10-22
- Data Source
  KAKENHI-PROJECT-22792055
[Presentation] 筋ジストロフィーモデルマウスにおけるRNA干渉を用いた咀嚼筋機能の回復2011
- Author(s)
  川合暢彦, 川上恵美, 中村彩花, 木内奈央, 田中栄二
- Organizer
  第47回日本顎口腔機能学会学術大会,兵庫医療大学神戸キャンパス
- Place of Presentation
  神戸
- Year and Date
  2011-10-22
- Data Source
  KAKENHI-PROJECT-22792055
[Presentation] Influences of the mastication on the development of jaw muscles in rats. International Joint Symposium on Oral Science : The University of Tokushima, Universitas Gadjah Mada2010
- Author(s)
  Kawai N.
- Organizer
  Niigata University, The Patra Bali
- Place of Presentation
  Bali, Indonesia
- Year and Date
  2010-12-17
- Data Source
  KAKENHI-PROJECT-22792055
[Presentation] Influences of the mastication on the development of jaw muscles in rats2010
- Author(s)
  Nobuhiko Kawai
- Organizer
  International Joint Symposium on Oral Science
- Place of Presentation
  Bali, Indonesia
- Year and Date
  2010-12-17
- Data Source
  KAKENHI-PROJECT-22792055
[Presentation] 特殊加工コラーゲンを単体としたマイオスタチンsiRNA投与による骨格筋量調節法の研究2010
- Author(s)
  川上恵実, 木内奈央, 足立太郎, 中村彩花, 川合暢彦, 田中栄二, 野地澄晴
- Organizer
  第69回日本矯正歯科学会大会,パシフィコ横浜
- Place of Presentation
  横浜市
- Year and Date
  2010-09-27
- Data Source
  KAKENHI-PROJECT-22792055
[Presentation] アテロコラーゲンを担体とした抗ユビキチン化ペプチドによる骨格筋萎縮抑制法の開発
- Author(s)
  川合暢彦ほか
- Organizer
  第73回日本矯正歯科学会大会
- Place of Presentation
  幕張メッセ・千葉県千葉市
- Year and Date
  2014-10-20 – 2014-10-22
- Data Source
  KAKENHI-PROJECT-26463095
[Presentation] The inhibition of skeletal muscle atrophy with anti-ubiquitination oligopeptide
- Author(s)
  Kawai N et al
- Organizer
  7th IADR/PER Congress
- Place of Presentation
  Dubrovnik, Croatia
- Year and Date
  2014-09-10 – 2014-09-13
- Data Source
  KAKENHI-PROJECT-26463095

1. TANAKA Eiji (40273693)

# of Collaborated Projects: 5 results

# of Collaborated Products: 7 results
2. KINOUCHI Nao (30457329)

# of Collaborated Projects: 4 results

# of Collaborated Products: 2 results
3. 二川健 (20263824)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
4. HIASA Masahiro (90511337)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. TOMITA Yuko (70380095)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 内田玲子 (60380094)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 泰江章博 (80380046)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 堀内信也 (70263861)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 桂智子 (70579002)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. NOJI Sumihare

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. MORI Hiroyo

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
12. HIRASAKA Katsuya

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. OHSAWA Yutaka

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 大沢裕

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 砂田芳秀

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KAWAI Nobuhiko 川合 暢彦

Research Projects

Research Products

Co-Researchers

ユビキチン-プロテアソーム系制御による廃用性筋萎縮抑制法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of the treatment of the skeletal muscle atrophy through the IGF-1 signaling in the growth periodPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development study of the nucleic acid innovative drug development for the chronic amyotrophy-related disease

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of the inhibition of skeletal muscle atrophy with anti-ubiquitination oligopeptidePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

口蓋形成術後の瘢痕形成抑制を目指した次世代RNA医薬品の開発

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The mechanism of the myofunctional recovery using RNA interference aiming at the treatment of the skeletal muscle disorderPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Novel therapy to prevent scar formation in wound healing via TGF-β/Smad3 signaling pathway

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

食物の物性により異なる咀嚼性刺激が顎骨および咀嚼筋の成長発育に及ぼす影響Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Effects of gum chewing exercise on maximum bite force according to facial morphology.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Effects of Co-Transfection with Myostatin-Targeting siRNA and ActRIIB-Fc Fusion Protein on Skeletal Muscle Growth2017

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Co-administration of myostatin-targeting siRNA and ActRIIB-Fc fusion protein increases masseter muscle mass and fiber size2017

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Prevention of skeletal muscle atrophy in vitro using anti-ubiquitination oligopeptide carried by atelocollagen2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Effects of Decreased Occlusal Loading during Growth on the Mandibular Bone Characteristics2015

Author(s)

Journal Title

Data Source

[Journal Article] Flavones Inhibit LPS-Induced Atrogin-1/MAFbx Expression in Mouse C2C12 Skeletal Myotubes2015

Author(s)

Journal Title

DOI

KAWAI Nobuhiko 川合暢彦