Kumagai Keigo 熊谷圭悟

… Alternative Names

熊谷圭悟クマガイケイゴ

KUMAGAI Keigo 熊谷圭悟

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Researcher Number	40443105
Other IDs
Affiliation (Current)	2025: 国立健康危機管理研究機構, 国立感染症研究所細胞科学部, 主任研究員
Affiliation (based on the past Project Information) *help	2018 – 2023: 国立感染症研究所, 細胞化学部, 主任研究官 2016: 国立感染症研究所, 細胞化学部, 主任研究官 2015: 国立感染症研究所, 細胞化学部, 主任研究員 2011 – 2014: 国立感染症研究所, 細胞化学部, 主任研究官 2009: 感染研・細胞化学部, 研究員 2008 – 2009: National Institute of Infectious Diseases, 細胞化学部, 研究員
Review Section/Research Field	Principal Investigator Biological pharmacy / Basic Section 47030:Pharmaceutical hygiene and biochemistry-related Except Principal Investigator Environmental and hygienic pharmacy / Functional biochemistry / Structural biochemistry
Keywords	Principal Investigator セラミド / スフィンゴミエリン / クラミジアトラコマティス / 阻害剤 / 細胞内寄生細菌 / スフィンゴミエリン合成酵素 / クラミジア・トラコマティス / クラミジア / 脂質輸送 / リン酸化 … More / FFATモチーフ / CERT / 抗菌薬 / 基質特異性 / 代謝標識 / 抗クラミジア薬 / 封入体 / メンブレンコンタクトサイト / VAP / 脂質 … More Except Principal Investigator 脂質輸送 / セラミド / クラミジア / HeLa細胞 / ゲノム編集 / 脂質 / リン酸化 / 生体膜 / スフィンゴ脂質 / ゴルジ体 / 小胞体 / スフィンゴミエリン / プレスクトリン相同ドメイン / クラミジア菌 / 性感染症 / ゲノム / ワクチン細胞基材 / Vero細胞 / 細胞内寄生 / 感染症 / ホスホイノシチド / プレクストリン相同ドメイン / 輸送 / タンパク質リン酸化 / 輸送タンパク質 / 膜輸送 / FFATモチーフ / 多重リン酸化 / キナーゼ / 阻害剤 Less

クラミジアのスフィンゴミエリン合成酵素の性状解析を基盤とした抗クラミジア薬の創生Principal Investigator
- Principal Investigator
  
  熊谷圭悟
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  National Institute of Infectious Diseases
Elucidation and functional analysis of the flow from host cell ceramide to Chlamydial sphingomyelin.Principal Investigator
- Principal Investigator
  
  Kumagai Keigo
- Project Period (FY)
  2018 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  National Institute of Infectious Diseases
Research of the regulatory mechanism of CERT-VAP interaction, from the causing factors to the caused effects.Principal Investigator
- Principal Investigator
  
  KUMAGAI KEIGO
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  National Institute of Infectious Diseases
Molecular strategy for the prevention of Chlamydia hijacking of a host lipid transport system
- Principal Investigator
  
  HANADA KENTARO
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Environmental and hygienic pharmacy
- Research Institution
  National Institute of Infectious Diseases
The regulatory mechanism for the CERT-VAP interactionPrincipal Investigator
- Principal Investigator
  
  KUMAGAI Keigo
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  National Institute of Infectious Diseases
Regulatory mechanism of intracellular trafficking of ceramide
- Principal Investigator
  
  HANADA KENTARO
- Project Period (FY)
  2010 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  National Institute of Infectious Diseases
The mechanism of dephosphorylation of CERT by the reduction of raftcomponentsPrincipal Investigator
- Principal Investigator
  
  熊谷圭悟
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  National Institute of Infectious Diseases
Determination of phosphorylation sites of the ceramide transport protein CERT, and a role of the phosphorylation
- Principal Investigator
  
  HANADA Kentaro
- Project Period (FY)
  2006 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  National Institute of Infectious Diseases

All 2023 2022 2020 2019 2018 2015 2014 2012 2010 2009 2008 2007 2006 Other

All Journal Article Presentation Book

[Book] セラミド研究の新展開2019
- Author(s)
  熊谷　圭悟
- Total Pages
  10
- Publisher
  食品化学新聞社
- ISBN
  9784916143358
- Data Source
  KAKENHI-PROJECT-18K06649
[Book] 医学のあゆみ2014
- Author(s)
  熊谷圭悟、花田賢太郎
- Total Pages
  7
- Publisher
  医歯薬出版株式会社
- Data Source
  KAKENHI-PROJECT-25460086
[Journal Article] ATG9A supports Chlamydia trachomatis infection via autophagy-independent mechanisms2023
- Author(s)
  Michitaka Suzuki, Tomoko Funakoshi, Keigo Kumagai, Masaaki Komatsu, Satoshi Waguri
- Journal Title
  
  Microbiology Spectrum
  
  Volume: 11(5) Issue: 5
- DOI
  10.1128/spectrum.02774-23
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06626, KAKENHI-ORGANIZER-19H05705, KAKENHI-PLANNED-19H05706, KAKENHI-PROJECT-21H04771, KAKENHI-PROJECT-23K27351
[Journal Article] Natural Ligand-Mimetic and Nonmimetic Inhibitors of the Ceramide Transport Protein CERT2022
- Author(s)
  Kentaro Hanada, Shota Sakai, Keigo Kumagai
- Journal Title
  
  Internal Journal of Molecular Sciences
  
  Volume: 23 Issue: 4 Pages: 2098-2098
- DOI
  10.3390/ijms23042098
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06649, KAKENHI-PLANNED-17H06417
[Journal Article] Chlamydial Infection-Dependent Synthesis of Sphingomyelin as a Novel Anti-Chlamydial Target of Ceramide Mimetic Compounds2022
- Author(s)
  Keigo Kumagai, Shota Sakai, Masaharu Ueno, Michiyo Kataoka, Shu Kobayashi, Kentaro Hanada
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 23 Issue: 23 Pages: 14697-14697
- DOI
  10.3390/ijms232314697
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06626, KAKENHI-PROJECT-18K06649, KAKENHI-PLANNED-17H06417
[Journal Article] Chlamydia trachomatis‐infected human cells convert ceramide to sphingomyelin without sphingomyelin synthases 1 and 22019
- Author(s)
  Tachida Yuriko、Kumagai Keigo、Sakai Shota、Ando Shuji、Yamaji Toshiyuki、Hanada Kentaro
- Journal Title
  
  FEBS Letters
  
  Volume: 594 Issue: 3 Pages: 519-529
- DOI
  10.1002/1873-3468.13632
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K07357, KAKENHI-PROJECT-18K06649, KAKENHI-ORGANIZER-17H06413, KAKENHI-PLANNED-17H06417
[Journal Article] Structure, functions and regulation of CERT, a lipid‐transfer protein for the delivery of ceramide at the ER?Golgi membrane contact sites2019
- Author(s)
  Kumagai Keigo、Hanada Kentaro
- Journal Title
  
  FEBS Letters
  
  Volume: 593 Issue: 17 Pages: 2366-2377
- DOI
  10.1002/1873-3468.13511
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06649, KAKENHI-ORGANIZER-17H06413, KAKENHI-PLANNED-17H06417
[Journal Article] Both the N- and C- terminal regions of the Chlamydial inclusion protein D (IncD) are required for interaction with the pleckstrin homology domain of the ceramide transport protein CERT2018
- Author(s)
  Kumagai Keigo、Elwell Cherilyn A.、Ando Shuji、Engel Joanne N.、Hanada Kentaro
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 505 Issue: 4 Pages: 1070-1076
- DOI
  10.1016/j.bbrc.2018.09.168
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06649, KAKENHI-PLANNED-17H06417
[Journal Article] Phosphoinositide binding by the PH domain in ceramide transfer protein (CERT) is inhibited by hyperphosphorylation of an adjacent serine-repeat motif2018
- Author(s)
  Sugiki Toshihiko、Egawa Daichi、Kumagai Keigo、Kojima Chojiro、Fujiwara Toshimichi、Takeuchi Koh、Shimada Ichio、Hanada Kentaro、Takahashi Hideo
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 293 Issue: 28 Pages: 11206-11217
- DOI
  10.1074/jbc.ra118.002465
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06649, KAKENHI-PUBLICLY-17H05836, KAKENHI-PUBLICLY-17H05873, KAKENHI-PLANNED-17H06417, KAKENHI-PUBLICLY-18H04626, KAKENHI-PROJECT-18H02393, KAKENHI-PROJECT-17H06097, KAKENHI-PROJECT-17H03641
[Journal Article] 効率的な細胞内セラミド輸送の仕組みとその制御2014
- Author(s)
  熊谷圭悟、花田賢太郎
- Journal Title
  
  医学の歩み
  
  Volume: 243 Pages: 1125-1131
- Data Source
  KAKENHI-PROJECT-25670065
[Journal Article] 効率的な細胞内セラミド輸送の仕組みとその制御2014
- Author(s)
  熊谷圭悟, 花田賢太郎
- Journal Title
  
  医学の歩み
  
  Volume: 248 Pages: 1125-1131
- Data Source
  KAKENHI-PROJECT-22370054
[Journal Article] Phosphoregulation of CERT at serine 315 in the interaction with VAMP-associated protein (VAP) for inter-organelle trafficking of ceramide in mammalian cells2014
- Author(s)
  Kumagai K, Kawano-Kawada M, and Hanada K
- Journal Title
  
  J Biol Chem
  
  Volume: 289 Issue: 15 Pages: 10748-10760
- DOI
  10.1074/jbc.m113.528380
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22370054, KAKENHI-PROJECT-25460086, KAKENHI-PROJECT-25670065
[Journal Article] Reconstitution assay system for ceramide transport with semi-intact cells2012
- Author(s)
  Kumagai K, Nishijima M, and Hanada K
- Journal Title
  
  Methods Cell Biol
  
  Volume: 108 Pages: 117-129
- DOI
  10.1016/b978-0-12-386487-1.00006-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22370054, KAKENHI-PROJECT-23790118
[Journal Article] Structural basis for the Golgi association by the pleckstrin homology domain of the ceramide trafficking protein (CERT)2012
- Author(s)
  Sugiki T, Takeuchi K, Yamaji T, Takano T, Tokunaga Y, Kumagai K, Hanada K, Takahashi H, and Shimada I
- Journal Title
  
  J Biol Chem
  
  Volume: 287 Issue: 40 Pages: 33706-33718
- DOI
  10.1074/jbc.m112.367730
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22370054, KAKENHI-PROJECT-23770164, KAKENHI-PROJECT-23790064, KAKENHI-PROJECT-23790118, KAKENHI-PROJECT-24370048, KAKENHI-PROJECT-24890263, KAKENHI-PUBLICLY-23107735, KAKENHI-PUBLICLY-24102524
[Journal Article] Crystal structures of the CERT START domain with inhibitors provide insights into the mechanism of ceramide transfer2010
- Author(s)
  Kudo N, Kumagai K, Matsubara R, Kobayashi S, Hanada K, Wakatsuki S, and Kato R
- Journal Title
  
  J Mol Biol
  
  Volume: 396 Issue: 2 Pages: 245-251
- DOI
  10.1016/j.jmb.2009.12.029
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22370054
[Journal Article] Crystal structures of the CERT START domain with inhibitors provide insights in to the mechanism of ceramide transfer.2010
- Author(s)
  Kudo N, Kumagai K, Matsubara R, Kobayashi S, Hanada K, Wakatsuki S, Kato R.
- Journal Title
  
  J Mol Biol 396(2)
  
  Pages: 245-51
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790092
[Journal Article] Crystal structures of the CERT START domain with inhibitors provide insights into the mechanism of ceramide transfer.2010
- Author(s)
  Kudo N, Kumagai K, Matsubara R, Kobayashi S, Hanada K, Wakatsuki S, Kato R.
- Journal Title
  
  J Mol Biol 396(2)
  
  Pages: 245-51
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790092
[Journal Article] Casein kinase Iγ2 down-regulates trafficking of ceramide in the synthesis of sphingomyelin2009
- Author(s)
  N. Tomishige, K. Kumagai, J. Kusuda, M. Nishijima and K. Hanada
- Journal Title
  
  Mol. Biol. Cell 20
  
  Pages: 348-357
- Data Source
  KAKENHI-PROJECT-18370049
[Journal Article] CERT-mediated trafficking of ceramide.2009
- Author(s)
  Kentaro Hanada, Keigo Kumagai, Nario Tomishige, Toshiyuki Yamaji
- Journal Title
  
  Biochim. Biophys. Acta 1791
  
  Pages: 684-691
- Data Source
  KAKENHI-PROJECT-18370049
[Journal Article] CERT-mediated trafficking of ceramide.2009
- Author(s)
  Hanada K, Kumagai K, Tomishige N, Yamaji T
- Journal Title
  
  Biochim Biophys Acta (未定)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790092
[Journal Article] Casein kinase Iγ2 down-regulates trafficking of ceramide in the synthesis of sphingomyelin.2009
- Author(s)
  Nario Tomishige, Keigo Kumagai, Jun Kusuda, Masahiro Nishijima, Kentaro Hanada
- Journal Title
  
  Mol. Biol. Cell 20
  
  Pages: 348-357
- Data Source
  KAKENHI-PROJECT-18370049
[Journal Article] Protein phosphatase 2C is an endoplasmic reticulum integral membrane protein that dephosphorylates the ceramide transport protein CERT to enhance its association with organelle membranes2008
- Author(s)
  S. Saito, H. Matsui, M. Kawano, K. Kumagai, N. Tomishige, K. Hanada, S. Echigo, S. Tamura and T. Kobayashi
- Journal Title
  
  J. Biol. Chem 283
  
  Pages: 6584-6593
- Data Source
  KAKENHI-PROJECT-18370049
[Journal Article] Structural basis for specific lipid recognition by CERT responsible for nonvesicular trafficking of ceramide.2008
- Author(s)
  Norio Kudo, Keigo Kumagai, Nario Tomishige, Toshiyuki Yamaji, Soichi Wakatsuki, Masahiro Nishijima, Kentaro Hanada, Ryuichi Kato
- Journal Title
  
  Proc. Natl. Acad. Sci. USA 105
  
  Pages: 488-493
- Data Source
  KAKENHI-PROJECT-18370049
[Journal Article] Structural basis for specific lipid recognition by CERT responsible for nonvesicular trafficking of ceramide2008
- Author(s)
  N. Kudo, K. Kumagai, N. Tomishige, T. Yamaji, S. Wakatsuki, M. Nishijima, K. Hanada and R. Kato
- Journal Title
  
  Proc. Natl. Acad. Sci. USA 105
  
  Pages: 488-493
- Data Source
  KAKENHI-PROJECT-18370049
[Journal Article] Casein kinase I{gamma}2 down-regulates trafficking of ceramide in the synthesis of sphingomyelin.2008
- Author(s)
  Tomishige N, Kumagai K, Kusuda J, Nishijima M, Hanada K.
- Journal Title
  
  Mol Biol Cell 20
  
  Pages: 348-57
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790092
[Journal Article] Two sphingolipid transfer proteins, CERT and FAPP2 : their roles in sphingolipid metabolism.2008
- Author(s)
  Yamaji T, Kumagai K, Tomishige N, Hanada K.
- Journal Title
  
  IUBMB Life 60
  
  Pages: 511-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790092
[Journal Article] Interorganelle trafficking of ceramide is regulated by phosphorylation-dependent cooperativity between the PH and START domains of CERT2007
- Author(s)
  Keigo Kumagai
- Journal Title
  
  The Journal of Biological Chemistry 282
  
  Pages: 17758-17766
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18370049
[Journal Article] CERT and intracellular trafficking of ceramide.2007
- Author(s)
  Kentaro Hanada, Keigo Kumagai, Nario Tomishige, Miyuki Kawano
- Journal Title
  
  Biochim. Biophys. Acta 1771
  
  Pages: 644-653
- Data Source
  KAKENHI-PROJECT-18370049
[Journal Article] Inter-organelle trafficking of ceramide is regulated by phosphorylation-dependent co-operativity between the PH and START domains of CERT2007
- Author(s)
  K. Kumagai, M. Kawano, F. Shinkai-Ouchi, M. Nishijima and K. Hanada
- Journal Title
  
  J. Biol. Chem 282
  
  Pages: 17758-17766
- Data Source
  KAKENHI-PROJECT-18370049
[Journal Article] Inter-organelle trafficking of ceramide is regulated by phosphorylation-dependent co-operativity between the PH and START domains of CERT.2007
- Author(s)
  Keigo Kumagai, Miyuki Kawano, Fumiko Shinkai-Ouchi, Masahiro Nishijima, Kentaro Hanada
- Journal Title
  
  J. Biol. Chem. 282
  
  Pages: 17758-17766
- Data Source
  KAKENHI-PROJECT-18370049
[Journal Article] Efficient trafficking of ceramide from the endoplasmic reticulum to the Golgi apparatus requires a VAMP-associated protein-interacting FFAT motif of CERT2006
- Author(s)
  M. Kawano, K. Kumagai, M. Nishijima and K. Hanada
- Journal Title
  
  J. Biol. Chem 281
  
  Pages: 30279-30288
- Data Source
  KAKENHI-PROJECT-18370049
[Journal Article] Efficient trafficking of ceramide from the endoplasmic reticulum to the Golgi apparatus requires a VAMP-associated protein-interacting FFAT motif of CERT.2006
- Author(s)
  Miyuki Kawano, Keigo Kumagai, Masahiro Nishijima, Kentaro Hanada
- Journal Title
  
  J. Biol. Chem. 281
  
  Pages: 30279-30288
- Data Source
  KAKENHI-PROJECT-18370049
[Presentation] 高浸透圧ストレスにより誘導されるリン酸化を介したセラミド輸送タンパク質CERTの小胞体への局在化亢進に関する解析2022
- Author(s)
  島崎健太朗, 熊谷圭悟, 酒井祥太, 山地俊之, 花田賢太郎
- Organizer
  第95回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-18K06649
[Presentation] 高浸透圧ストレスにより誘導されるリン酸化を介したセラミド輸送タンパク質CERTの小胞体への局在化亢進に関する解析2022
- Author(s)
  島崎健太朗, 熊谷圭悟, 酒井祥太, 山地俊之, 花田賢太郎
- Organizer
  第95回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-22K06626
[Presentation] 宿主細胞からクラミジア・トラコマティスへのセラミドフローを担う分子機構2022
- Author(s)
  熊谷圭悟、杉木俊彦、児嶋長次郎、花田賢太郎
- Organizer
  第94回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-18K06649
[Presentation] 偏性細胞内寄生細菌クラミジア・トラコマティスによる宿主セラミドの獲得機構2020
- Author(s)
  熊谷圭悟
- Organizer
  第93回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-18K06649
[Presentation] CERT阻害剤HPA-12の立体異性体が示す抗クラミジア活性とその作用機序2020
- Author(s)
  熊谷圭悟
- Organizer
  第13回セラミド研究会
- Data Source
  KAKENHI-PROJECT-18K06649
[Presentation] セラミド輸送タンパク質CERTと細胞内寄生細菌クラミジア封入体膜タンパク質IncDとの会合機序2019
- Author(s)
  花田賢太郎、熊谷圭悟、杉木俊彦、新家粧子、小林直宏、江川大地、藤原敏道、児嶋長次郎
- Organizer
  第61回日本脂質生化学会
- Data Source
  KAKENHI-PROJECT-18K06649
[Presentation] Structural basis for the specific association between the Chlamydia trachomatis inclusion membrane protein IncD and the PH domain of the ceramide transport protein CERT.2019
- Author(s)
  Toshihiko Sugiki, Keigo Kumagai, Shoko Shinya, Naohiro Kobayashi, Daichi Egawa, Toshimichi Fujiwara, Kentaro Hanada, Chojiro Kojima
- Organizer
  60th ICBL
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06649
[Presentation] クラミジア封入体膜蛋白質IncDが脂質輸送蛋白質CERTに選択的に結合する分子機構の溶液NMR解析2019
- Author(s)
  杉木俊彦、熊谷圭悟、新家粧子、小林直宏、藤原敏道、花田賢太郎、児嶋長次郎
- Organizer
  第42回分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18K06649
[Presentation] クラミジアのエフェクタータンパク質IncDと宿主細胞由来のセラミド輸送タンパク質CERTのPHドメインとの結合にはIncDのN末領域とC末領域が必要である2019
- Author(s)
  熊谷圭悟、花田賢太郎
- Organizer
  第３回オルガネラゾーン研究会
- Data Source
  KAKENHI-PROJECT-18K06649
[Presentation] Chlamydia trachomatis requires host ceramide-transport protein CERT but not sphingomyelin synthases for the infection and proliferation in HeLa cells2019
- Author(s)
  Keigo Kumagai, Yuriko Tachida, Shota Sakai, Toshiyuki Yamaji, Kentaro Hanada
- Organizer
  9th CBRS
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06649
[Presentation] Chlamydia trachomatis requires host ceramide-transport protein CERT but not sphingomyelin synthases for the infection and proliferation in HeLa cells.2019
- Author(s)
  Keigo Kumagai, Yuriko Tachida, Shota Sakai, Toshiyuki Yamaji, Kentaro Hanada
- Organizer
  60th ICBL
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06649
[Presentation] 宿主細胞のスフィンゴミエリン合成酵素は Chlamydia trachomatis の細胞内寄生に必須ではない2018
- Author(s)
  熊谷圭悟、立田由里子、酒井祥太、山地俊之、花田賢太郎
- Organizer
  第36回クラミジア研究会
- Data Source
  KAKENHI-PROJECT-18K06649
[Presentation] 宿主因子CERTがChlamydia trachomatis感染に果たす役割2015
- Author(s)
  熊谷圭悟、山地俊之、山本章嗣、安藤秀二、花田賢太郎
- Organizer
  第33回クラミジア研究会
- Place of Presentation
  岡山大学鹿田キャンパス
- Year and Date
  2015-10-24
- Data Source
  KAKENHI-PROJECT-25460086
[Presentation] クラミジア・トラコマティスによってハイジャックされる宿主セラミド輸送機構2015
- Author(s)
  熊谷圭悟、山地俊之、山本章嗣、花田賢太郎
- Organizer
  BMB 2015
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25460086
[Presentation] Structural basis for the recognition of phosphatidylinositol 4-monophosphate by the pleckstrin homology domain of the ceramide trafficking protein CERT2012
- Author(s)
  Kentaro Hanada, Toshihiko Sugiki, Koh Takeuchi, Yuji Tokunaga, Hiroaki Terasawa, Keigo Kumagai, Toshiyuki Yamaji, Hideo Takahashi, and Ichio Shimada
- Organizer
  第85回日本生化学会大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-22370054
[Presentation] セラミド輸送タンパク質CERTと小胞体膜タンパク質VAPとの相互作用制御2012
- Author(s)
  熊谷圭悟
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  福岡県福岡市
- Year and Date
  2012-12-16
- Data Source
  KAKENHI-PROJECT-23790118
[Presentation] セラミド輸送タンパク質CERT とVAP との相互作用制御2012
- Author(s)
  熊谷圭悟, 花田賢太郎
- Organizer
  第85回日本生化学会大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-22370054
[Presentation] Structural basis for the preferential recognition of phosphatidylinositol 4-monophosphate by the pleckstrin homology domain of the ceramide trafficking protein CERT2012
- Author(s)
  Hanada K, Sugiki T, Takeuchi K, Tokunaga, Y, Terasawa, H, Kumagai, K, Yamaji, T, Takahashi, H, Shimada, I
- Organizer
  2012 ASBMB Special Symposium, Frontiers in Lipid Biology
- Place of Presentation
  Banff, Canada
- Data Source
  KAKENHI-PROJECT-22370054
[Presentation] Crystal structures of the CERT START domain in complex with lipid substrates and specific inhibitors provide insights into the molecular mechanisms of ceramide transfer2010
- Author(s)
  Kudo N, Kumagai K, Matsubara R, Kobayashi S, Wakatsuki S, Hanada, K, and Kato, R
- Organizer
  The 27th Naito Conference on Membrane Dynamics and Lipid Biology [I]
- Place of Presentation
  Sapporo
- Data Source
  KAKENHI-PROJECT-22370054
[Presentation] セラミド輸送タンパク質CERTのリン酸化による機能制御
- Author(s)
  熊谷圭悟、花田賢太郎
- Organizer
  第56回日本脂質生化学会大会
- Place of Presentation
  東大阪市
- Year and Date
  2015-06-06 – 2015-06-07
- Data Source
  KAKENHI-PROJECT-25670065
[Presentation] CERT-VAP間の相互作用調節を介したセラミド輸送の制御
- Author(s)
  花田賢太郎、熊谷圭悟
- Organizer
  第9回スフィンゴテラピー研究会
- Place of Presentation
  加賀市
- Year and Date
  2014-07-18 – 2014-07-19
- Data Source
  KAKENHI-PROJECT-25670065
[Presentation] セラミド輸送タンパク質CERTと小胞体膜タンパク質VAPとの相互作用制御
- Author(s)
  熊谷圭悟
- Organizer
  第85回　日本生化学大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23790118
[Presentation] CERT-VAP間の相互作用調節を介したセラミド輸送の制御
- Author(s)
  熊谷圭悟，花田賢太郎
- Organizer
  第56回脂質生化学会
- Place of Presentation
  大阪府
- Year and Date
  2014-06-06 – 2014-06-07
- Data Source
  KAKENHI-PROJECT-25460086
[Presentation] CERT-VAP間の相互作用調節を介したセラミド輸送の制御
- Author(s)
  花田賢太郎，熊谷圭悟
- Organizer
  第9回スフィンゴテラピー研究会
- Place of Presentation
  Seoul
- Year and Date
  2014-07-18 – 2014-07-19
- Data Source
  KAKENHI-PROJECT-25460086

1. HANADA Kentaro (30192701)

# of Collaborated Projects: 5 results

# of Collaborated Products: 28 results
2. YAMAJI Toshiyuki (50332309)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
3. TOMISHIGE Nario (10435711)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
4. KAWANO Miyuki (10454498)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
5. SAITO Kyoko (70235034)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. SUGIKI Toshihiko (70635698)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Kumagai Keigo 熊谷 圭悟

熊谷 圭悟 クマガイ ケイゴ

KUMAGAI Keigo 熊谷 圭悟

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クラミジアのスフィンゴミエリン合成酵素の性状解析を基盤とした抗クラミジア薬の創生Principal Investigator

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Elucidation and functional analysis of the flow from host cell ceramide to Chlamydial sphingomyelin.Principal Investigator

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Research of the regulatory mechanism of CERT-VAP interaction, from the causing factors to the caused effects.Principal Investigator

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Molecular strategy for the prevention of Chlamydia hijacking of a host lipid transport system

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The regulatory mechanism for the CERT-VAP interactionPrincipal Investigator

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Regulatory mechanism of intracellular trafficking of ceramide

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The mechanism of dephosphorylation of CERT by the reduction of raftcomponentsPrincipal Investigator

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Determination of phosphorylation sites of the ceramide transport protein CERT, and a role of the phosphorylation

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[Book] セラミド研究の新展開2019

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[Book] 医学のあゆみ2014

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[Journal Article] ATG9A supports Chlamydia trachomatis infection via autophagy-independent mechanisms2023

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[Journal Article] Natural Ligand-Mimetic and Nonmimetic Inhibitors of the Ceramide Transport Protein CERT2022

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[Journal Article] Chlamydial Infection-Dependent Synthesis of Sphingomyelin as a Novel Anti-Chlamydial Target of Ceramide Mimetic Compounds2022

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Kumagai Keigo 熊谷圭悟

熊谷圭悟クマガイケイゴ

KUMAGAI Keigo 熊谷圭悟