FUKUSHI Junichi 福士純一

… Alternative Names

福士純一フクシジュンイチ

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Researcher Number	40444806
Affiliation (Current)	2025: 独立行政法人国立病院機構九州医療センター(臨床研究センター), その他部局等, 整形外科・リウマチ科担当部長
Affiliation (based on the past Project Information) *help	2025: 独立行政法人国立病院機構九州医療センター(臨床研究センター), その他部局等, 整形外科・リウマチ科担当部長 2020 – 2023: 独立行政法人国立病院機構九州医療センター(臨床研究センター), その他部局等, 整形外科・リウマチ科担当部長 2017: 九州大学, 医学研究院, 准教授 2016: 九州大学, 大学病院, 講師 2007 – 2016: Kyushu University, 大学病院, 助教
Review Section/Research Field	Principal Investigator Orthopaedic surgery / Basic Section 56020:Orthopedics-related Except Principal Investigator Orthopaedic surgery
Keywords	Principal Investigator 骨溶解症 / 骨破壊 / MMP2 / MT1-MMP / MMP-2 / コラーゲン代謝 / 骨・関節破壊 / MMP２ / 骨破壞 / 関節病学 … More Except Principal Investigator … More 薬剤反応性 / マイクロアレイ / トランスレーショナルリサーチ / 癌 / 血管 / 骨・軟部腫瘍学 / 臨床応用 / 分子標的治療 / 骨転移 / 腫瘍随伴マクロファージ / Vascular endothelial growth factor (VEGF) basic Fibroblast growth factor (bFGF) / 血管新生 / 破骨細胞 / 腫瘍性骨破壊 Less

MMP2/MT1-MMP活性化障害による骨・関節破壊の機序の解明Principal Investigator
- Principal Investigator
  
  福士純一
- Project Period (FY)
  2025 – 2029
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  National Hospital Organization, Kyushu Medical Center (Clinical Institute)
コラーゲン代謝障害による骨・関節破壊の分子機序の解明Principal Investigator
- Principal Investigator
  
  福士純一
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  National Hospital Organization, Kyushu Medical Center (Clinical Institute)
The mechanism of bone/joint destruction by impaired MMP2/MT1-MMPPrincipal Investigator
- Principal Investigator
  
  Fukushi Jun-ichi
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Kyushu University
悪性骨軟部腫瘍における薬剤耐性獲得機構の解明
- Principal Investigator
  
  岩本幸英
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Kyushu University
The effects of mutated MMP2 on bone and jointPrincipal Investigator
- Principal Investigator
  
  FUKUSHI Jun-ichi
- Project Period (FY)
  2010 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Kyushu University
Analysis of correlation of angiogeneis and osteoclastogenesis/osteoclastic bone resorption in tumore-induced destruction of bone
- Principal Investigator
  
  IWAMOTO Yukihide
- Project Period (FY)
  2007 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Kyushu University
Mechanisms of osteolysis associated with MMP2 mutationPrincipal Investigator
- Principal Investigator
  
  FUKUSHI Jun-ichi
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Kyushu University

All 2015 2013 2010 2009 Other

All Journal Article Presentation

[Journal Article] Tumour-associated macrophages correlate with poor prognosis in myxoid liposarcoma and promote cell motility and invasion via the HB-EGF-EGFR-PI3K/Akt pathways2015
- Author(s)
  Nabeshima Y., Matsumoto Y., Iwamoto Y., et al
- Journal Title
  
  British J Cancer
  
  Volume: NA Issue: 3 Pages: 1-9
- DOI
  10.1038/bjc.2014.637
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-23592192, KAKENHI-PROJECT-25293088, KAKENHI-PROJECT-25293325, KAKENHI-PROJECT-15K10449, KAKENHI-PROJECT-24791574, KAKENHI-PROJECT-26713046
[Journal Article] Cadherin-11 regulates the metastasis of Ewing sarcoma cells to bone.2015
- Author(s)
  Hatano M, Matsumoto Y, Fukushi J, Matsunobu T, Endo M, Okada S, Iura K, Kamura S, Fujiwara T, Iida K, Fujiwara Y, Nabeshima A, Yokoyama N, Fukushima S, Oda Y, Iwamoto Y.
- Journal Title
  
  Clin Exp Metastasis.
  
  Volume: 32 Issue: 6 Pages: 579-591
- DOI
  10.1007/s10585-015-9729-y
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10449, KAKENHI-PROJECT-24791574, KAKENHI-PROJECT-25293088, KAKENHI-PROJECT-25293325, KAKENHI-PROJECT-25713053, KAKENHI-PROJECT-26713046
[Journal Article] Y-box binding protein-1 regulates cell proliferation and is associated with clinical outcomes of osteosarcoma.2013
- Author(s)
  Fujiwara-Okada Y, Matsumoto Y, Fukushi J, Setsu N, Matsuura S, Kamura S, Fujiwara T, Iida K, Hatano M, Nabeshima A, Yamada H, Ono M, Oda Y, Iwamoto Y.
- Journal Title
  
  Br J Cancer
  
  Volume: 108 Issue: 4 Pages: 836-847
- DOI
  10.1038/bjc.2012.579
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592192, KAKENHI-PROJECT-25293325
[Journal Article] miR-125b develops chemoresistance in Ewing sarcoma/primitive neuroectodermal tumor.2013
- Author(s)
  Iida K
- Journal Title
  
  Cancer Cell International
  
  Volume: 13 Issue: 1 Pages: 21-21
- DOI
  10.1186/1475-2867-13-21
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390107, KAKENHI-PROJECT-23592192, KAKENHI-PROJECT-25293325
[Journal Article] 進行骨肉腫例に対するsecond-line chemotherapyと新規薬剤療法の開発-現状と展望2010
- Author(s)
  松本嘉寛, 福士純一, 岩本幸英
- Journal Title
  
  整形外科
  
  Volume: 61(8) Pages: 815-20
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390397
[Journal Article] Role of the VEGF-Flt-1-FAK pathway in the pathogenesis of osteoclastic bone destruction of giant cell tumors of bone2010
- Author(s)
  Matsumoto Y, Fukushi J, Sakamoto A, Iwamoto Y, et al.
- Journal Title
  
  J Orthop Surg Res
  
  Volume: 5(1) Pages: 85-85
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390397
[Journal Article] Basic fibroblast growth factor in the bone microenvironment enhances cell motility and invasion of Ewing's sarcoma family of tumours by activating the FGFR1-PI3K-Rac1 pathway.2010
- Author(s)
  Kamura S, Matsumoto Y, Fukushi J, Iwamoto Y, et al.
- Journal Title
  
  Br J Cancer 103(3)
  
  Pages: 370-381
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390397
[Journal Article] Role of the VEGF-Flt-1-FAK pathway in the pathogenesis of osteoclastic bone destruction of giant cell tumors of bone.2010
- Author(s)
  Matsumoto Y, Fukushi J, Sakamoto A, Iwamoto Y, et al.
- Journal Title
  
  J Orthop Surg Res 5(1)
  
  Pages: 85-85
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390397
[Journal Article] Basic fibroblast growth factor in the bone microenvironment enhances cell motility and invasion of Ewing's sarcoma family of tumours by activating the FGFR1-PI3K-Rac1 pathway2010
- Author(s)
  Kamura S, Matsumoto Y, Fukushi J, Iwamoto Y, et al.
- Journal Title
  
  Br J Cancer
  
  Volume: 103(3) Pages: 370-81
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390397
[Journal Article] CCAAT/enhancer binding protein beta mediates expression of matrix metalloproteinase 13 in human articular chondrocytes in inflammatory arthritis.2009
- Author(s)
  Hayashida M, Fukushi J, Iwamoto Y, et al.
- Journal Title
  
  Arthritis Rheum 60(3)
  
  Pages: 708-716
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390397
[Journal Article] CCAAT/enhancer binding protein beta mediates expression of matrix metalloproteinase 13 in human articular chondrocytes in inflammatory arthritis.2009
- Author(s)
  Hayashida M, Fukushi J, Iwamoto Y, et al.:
- Journal Title
  
  Arthritis Rheum, 60(3) :
  
  Pages: 708-16
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390397
[Presentation] 悪性末梢神経鞘腫の薬剤耐性機序の検討2015
- Author(s)
  福島　俊, 松本嘉寛, 福士純一, 播广谷勝三, 岩本幸英
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場（愛知）
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-25293325
[Presentation] 粘液型脂肪肉腫の臨床成績と温熱放射線療法の有用性および腫瘍体積縮小に関与する組織学的因子の検討2015
- Author(s)
  横山信彦, 松延知哉, 福島　俊, 鍋島　央, 畑野美穂子, 藤原悠子, 飯田圭一郎, 遠藤　誠, 松本嘉寛, 福士純一, 播广谷勝三, 井浦国生, 小田義直, 岩本幸英
- Organizer
  第48回日本整形外科学会骨・軟部腫瘍学術集会
- Place of Presentation
  サンポートホール高松、かがわ国際会議場（香川）
- Year and Date
  2015-07-09
- Data Source
  KAKENHI-PROJECT-25293325
[Presentation] 悪性末梢神経鞘腫の薬剤耐性機序の検討2015
- Author(s)
  福島　俊, 鍋島　央, 松本嘉寛, 横山信彦, 畑野美穂子, 遠藤　誠, 松延知哉, 福士純一, 播广谷勝三, 岩本幸英
- Organizer
  第48回日本整形外科学会骨・軟部腫瘍学術集会
- Place of Presentation
  サンポートホール高松、かがわ国際会議場（香川）
- Year and Date
  2015-07-09
- Data Source
  KAKENHI-PROJECT-25293325
[Presentation] 粘液型脂肪肉腫の臨床成績と温熱放射線療法の有用性および腫瘍体積縮小に関与する組織学的因子の検討2015
- Author(s)
  横山信彦, 松延知哉, 福島　俊, 鍋島　央, 畑野美穂子, 藤原悠子, 飯田圭一郎, 遠藤　誠, 松本嘉寛, 福士純一, 播广谷勝三, 井浦国生, 小田義直, 岩本幸英
- Organizer
  第53回日本癌治療学会学術集会
- Place of Presentation
  国立京都国際会館（京都）
- Year and Date
  2015-10-29
- Data Source
  KAKENHI-PROJECT-25293325
[Presentation] 滑膜肉腫細胞株におけるアドリアマイシン耐性株およびパゾパニブ耐性株の樹立と耐性メカニズムの検討2015
- Author(s)
  横山信彦, 松延知哉, 福島　俊, 鍋島　央, 畑野美穂子, 遠藤　誠, 松本嘉寛, 福士純一, 播广谷勝三, 岩本幸英
- Organizer
  第48回日本整形外科学会骨・軟部腫瘍学術集会
- Place of Presentation
  サンポートホール高松、かがわ国際会議場（香川）
- Year and Date
  2015-07-09
- Data Source
  KAKENHI-PROJECT-25293325
[Presentation] Ewing 肉腫におけるcadherin-11の発現は骨転移を促進する2015
- Author(s)
  畑野美穂子, 松本嘉寛, 福士純一, 松延知哉, 遠藤　誠, 岡田誠司, 井浦国生, 嘉村　聡, 藤原稔史, 飯田圭一郎, 藤原悠子, 鍋島　央, 横山信彦, 福島　俊, 小田義直, 岩本幸英
- Organizer
  第48回日本整形外科学会骨・軟部腫瘍学術集会
- Place of Presentation
  サンポートホール高松、かがわ国際会議場（香川）
- Year and Date
  2015-07-09
- Data Source
  KAKENHI-PROJECT-25293325
[Presentation] Ewing肉腫におけるcadherin-11の発現と臨床成績の相関2013
- Author(s)
  畑野美穂子、松本嘉寛、福士純一、播广谷勝三、松延知哉、飯田圭一郎、藤原悠子、鍋島央、横山信彦、小田義直、岩本幸英
- Organizer
  第86回日本整形外科学会学術総会
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-25293325
[Presentation] 粘液型脂肪肉腫の長期臨床成績と温熱放射線療法の有用性の検討2013
- Author(s)
  横山信彦、松延知哉、鍋島央、畑野美穂子、藤原悠子、飯田圭一郎、松本嘉寛、福士純一、播广谷勝三、岩本幸英
- Organizer
  第86回日本整形外科学会学術総会
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-25293325
[Presentation] 膝関節周囲に発生した骨巨細胞腫の術後成績の検討2013
- Author(s)
  横山信彦、松延知哉、福士純一、松本嘉寛、播广谷勝三、飯田圭一郎、藤原悠子、畑野美穂子、鍋島央、岩本幸英
- Organizer
  第46回日本整形外科骨･軟部腫瘍学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-25293325
[Presentation] 脂肪肉腫における腫瘍関連マクロファージの役割の検討2013
- Author(s)
  鍋島央、松本嘉寛、福士純一、飯田圭一郎、藤原悠子、畑野美穂子、横山信彦、松延知哉、播广谷勝三、岩本幸英
- Organizer
  第46回日本整形外科骨･軟部腫瘍学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-25293325
[Presentation] miR-125bはEwing肉腫の多剤薬剤耐性に関与する2013
- Author(s)
  飯田圭一郎、福士純一、松本嘉寛、松延知哉、畑野美穂子、鍋島央、横山信彦、岩本幸英
- Organizer
  第28回日本整形外科基礎学術集会
- Place of Presentation
  千葉
- Data Source
  KAKENHI-PROJECT-25293325
[Presentation] Basic Fibroblast Growth Factor Invasive and Metastatic Phenotypeof Ewing's Sarcoma Cells by Stimulating the Cell Migration2010
- Author(s)
  Kamura S, Matsumoto Y, Fukushi J, Iwamoto Y, et al.
- Organizer
  56th Annual Meeting of the Orthopaedic Research Society
- Place of Presentation
  New Orleans, Louisiana
- Data Source
  KAKENHI-PROJECT-19390397
[Presentation] Basic fibroblast growth factorによるEwing肉腫細胞の転移・浸潤能亢進メカニズムの解明2010
- Author(s)
  嘉村聡志, 松本嘉寛, 福士純一, 岩本幸英, 他
- Organizer
  第43回日本整形外科学会骨・軟部腫瘍学術集会
- Place of Presentation
  京王プラザホテル(東京)
- Data Source
  KAKENHI-PROJECT-19390397
[Presentation] Ewing肉腫におけるtumor associated macrophage(TAM)の役割2010
- Author(s)
  藤原稔史, 福士純一, 松本嘉寛, 岩本幸英, 他
- Organizer
  第43回日本整形外科学会骨・軟部腫瘍学術集会
- Place of Presentation
  京王プラザホテル(東京)
- Data Source
  KAKENHI-PROJECT-19390397
[Presentation] Ewing's Sarcoma Cells Induce Osteoclastic Differentiation of Tumor-Associated Macrophage2010
- Author(s)
  Fujiwara T, Fukushi J, Matsumoto Y, Iwamoto Y, et al.
- Organizer
  56th Annual Meeting of the Orthopaedic Research Society
- Place of Presentation
  New Orleans, Louisiana
- Data Source
  KAKENHI-PROJECT-19390397
[Presentation] ユーイング肉腫における腫瘍関連マクロファージの役割2010
- Author(s)
  藤原稔史, 福士純一, 松本嘉寛, 岩本幸英, 他
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  大阪国際会議場,リーガロイヤルホテル(大阪)
- Data Source
  KAKENHI-PROJECT-19390397
[Presentation] 粘液型脂肪肉腫においてマクロファーシの浸潤は予後不良因子である
- Author(s)
  鍋島央, 松本嘉寛, 福士純一, 井浦国生, 飯田圭一郎, 播广谷勝三, 小田義直, 岩本幸英
- Organizer
  第 73回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-25293325
[Presentation] 粘液型脂肪肉腫においてマクロファージの浸潤は予後不良因子である
- Author(s)
  鍋島央, 松本嘉寛, 福士純一, 松延知哉, 井浦国生, 小田義直, 畑野美穂子, 播广谷勝三, 岩本幸英
- Organizer
  第46回日本結合組織学会学術大会&第61回マトリックス研究会大会合同学術集会
- Place of Presentation
  名古屋
- Year and Date
  2014-06-05 – 2014-06-07
- Data Source
  KAKENHI-PROJECT-25293325
[Presentation] 膝関節周囲に発生した骨巨細胞腫の術後成績の検討
- Author(s)
  横山信彦, 松延知哉, 福士純一, 松本嘉寛, 播广谷勝三, 飯田圭一郎, 藤原悠子, 畑野美穂子, 鍋島央, 福島俊, 岩本幸英
- Organizer
  第52回日本癌治療学会
- Place of Presentation
  横浜
- Year and Date
  2014-08-28 – 2014-08-30
- Data Source
  KAKENHI-PROJECT-25293325
[Presentation] マクロファージはEGFRを介して脂肪肉腫の細胞運動能・浸潤能を促進する
- Author(s)
  鍋島央, 松本嘉寛, 福士純一, 松延知哉, 藤原稔史, 飯田圭一郎, 藤原悠子, 畑野美穂子, 横山信彦, 播广谷勝三, 岩本幸英
- Organizer
  第47回日本整形外科学会骨・軟部腫瘍学術集会
- Place of Presentation
  大阪
- Year and Date
  2014-07-17 – 2014-07-18
- Data Source
  KAKENHI-PROJECT-25293325
[Presentation] 当科におけるデスモイド型線維腫症の治療成績と今後の展望
- Author(s)
  福島俊, 横山信彦, 鍋島央, 畑野美穂子, 遠藤誠, 松延知哉, 福士純一, 松本嘉寛, 播广谷勝三, 小田義直, 岩本幸英
- Organizer
  第47回日本整形外科学会骨・軟部腫瘍学術集会
- Place of Presentation
  大阪
- Year and Date
  2014-07-17 – 2014-07-18
- Data Source
  KAKENHI-PROJECT-25293325
[Presentation] 骨腫瘍が鑑別診断となったfocal periphyseal edema(FOPE)の4例
- Author(s)
  横山信彦, 松延知哉, 松本嘉寛, 播广谷勝三, 遠藤誠, 福士純一, 福島俊, 鍋島央, 畑野美穂子, 岡崎賢, 岩本幸英
- Organizer
  第47回日本整形外科学会骨・軟部腫瘍学術集会
- Place of Presentation
  大阪
- Year and Date
  2014-07-17 – 2014-07-18
- Data Source
  KAKENHI-PROJECT-25293325

1. MATSUMOTO Yoshihiro (10346794)

# of Collaborated Projects: 3 results

# of Collaborated Products: 30 results
2. IWAMOTO Yukihide (00213322)

# of Collaborated Projects: 2 results

# of Collaborated Products: 29 results
3. ODA Yoshinao (70291515)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
4. TSUNEYOSHI Masazumi (20091259)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. SAKAMOTO Akio (40335964)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
6. 山田久方 (20363369)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 松延知哉 (20543416)

# of Collaborated Projects: 1 results

# of Collaborated Products: 15 results
8. 岡田誠司 (30448435)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. 松本和

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

FUKUSHI Junichi 福士 純一

福士 純一 フクシ ジュンイチ

Research Projects

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MMP2/MT1-MMP活性化障害による骨・関節破壊の機序の解明Principal Investigator

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コラーゲン代謝障害による骨・関節破壊の分子機序の解明Principal Investigator

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The mechanism of bone/joint destruction by impaired MMP2/MT1-MMPPrincipal Investigator

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悪性骨軟部腫瘍における薬剤耐性獲得機構の解明

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The effects of mutated MMP2 on bone and jointPrincipal Investigator

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Analysis of correlation of angiogeneis and osteoclastogenesis/osteoclastic bone resorption in tumore-induced destruction of bone

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Mechanisms of osteolysis associated with MMP2 mutationPrincipal Investigator

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[Journal Article] Tumour-associated macrophages correlate with poor prognosis in myxoid liposarcoma and promote cell motility and invasion via the HB-EGF-EGFR-PI3K/Akt pathways2015

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[Journal Article] Cadherin-11 regulates the metastasis of Ewing sarcoma cells to bone.2015

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[Journal Article] Y-box binding protein-1 regulates cell proliferation and is associated with clinical outcomes of osteosarcoma.2013

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[Journal Article] miR-125b develops chemoresistance in Ewing sarcoma/primitive neuroectodermal tumor.2013

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[Journal Article] 進行骨肉腫例に対するsecond-line chemotherapyと新規薬剤療法の開発-現状と展望2010

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[Journal Article] Role of the VEGF-Flt-1-FAK pathway in the pathogenesis of osteoclastic bone destruction of giant cell tumors of bone2010

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[Journal Article] Basic fibroblast growth factor in the bone microenvironment enhances cell motility and invasion of Ewing's sarcoma family of tumours by activating the FGFR1-PI3K-Rac1 pathway.2010

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[Journal Article] Role of the VEGF-Flt-1-FAK pathway in the pathogenesis of osteoclastic bone destruction of giant cell tumors of bone.2010

FUKUSHI Junichi 福士純一

福士純一フクシジュンイチ

[Presentation] Ewing 肉腫におけるcadherin-11の発現は骨転移を促進する2015