Egawa Kiyoshi 江川潔

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EGAWA Kiyoshi 江川潔

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Researcher Number	40450829
Other IDs	https://orcid.org/0000-0001-8224-7012
Affiliation (Current)	2025: 北海道大学, 大学病院, 講師
Affiliation (based on the past Project Information) *help	2025: 北海道大学, 大学病院, 講師 2017 – 2023: 北海道大学, 医学研究院, 助教 2016: 北海道大学, 医学研究科, 助教 2015: 北海道大学, 大学病院, 医員 2011: 浜松医科大学, 医学部, 特任研究員
Review Section/Research Field	Principal Investigator Basic Section 52050:Embryonic medicine and pediatrics-related / Pediatrics Except Principal Investigator Basic Section 48020:Physiology-related / Complex systems / Embryonic/Neonatal medicine
Keywords	Principal Investigator GABA / アンジェルマン症候群 / GABA持続抑制 / 自閉症スペクトラム / GABA作動性抑制 / 脳波異常 / 知的発達症 / てんかん / GABA受容体 / 難治てんかん … More / ドラベ症候群 / GABA抑制 / 発達障害 / 精神運動発達遅滞 / 遺伝性てんかん / GABA作動性持続抑制 / 自閉症モデル / GABAシナプス伝達 / 自閉症 / 小脳失調 … More Except Principal Investigator GABA / タウリン / 神経回路 / クロライド / カルシウム / 神経ネットワーク / クロライドイオン / 光イメージング / 生物時計 / 塩素イオン / 概日リズム / 神経細胞 / イメージング / 視交叉上核 / 概日時計 / 膜電流振動 / ノイズ / Ca2＋振動 / NKCC1 / KCC2 / Cｌ－ / てんかん / γ振動 / Ca2+振動 / Cl- / 発達障害 / 母体ストレス / 細胞移動 / 大脳皮質 / 皮質板細胞 / クロライドホメオスタシス Less

遺伝性自閉スペクトラム症における肥満の病態生理－疾患モデルマウスによる解明Principal Investigator
- Principal Investigator
  
  江川潔
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Hokkaido University
ドラベ症候群におけるα2サブユニット選択的GABA(A)受容体賦活薬の有効性検証Principal Investigator
- Principal Investigator
  
  江川潔
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Hokkaido University
Why is the circadian rhythm center composed of GABAergic neurons?
- Principal Investigator
  
  Enoki Ryosuke
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 48020:Physiology-related
- Research Institution
  National Institutes of Natural Sciences
Pathophysiological impact of diverse deregulation of tonic inhibition in Angelman syndromePrincipal Investigator
- Principal Investigator
  
  Egawa Kiyoshi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Hokkaido University
Mechanisms and therapeutic strategy for cognitive dysfunction in Angelman syndromePrincipal Investigator
- Principal Investigator
  
  EGAWA Kiyoshi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Hokkaido University
Modal shifts in cellular and network oscillations
- Principal Investigator
  
  FUKUDA Atsuo
- Project Period (FY)
  2015 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  Hamamatsu University School of Medicine
Perturbation of developmental Cl^-homeodynamics may underlie fetal and neonatal brain disorders
- Principal Investigator
  
  FUKUDA Atsuo
- Project Period (FY)
  2011
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Embryonic/Neonatal medicine
- Research Institution
  Hamamatsu University School of Medicine
アンジェルマン症候群モデルマウスにおける小脳機能障害の電気生理学的検討Principal Investigator
- Principal Investigator
  
  江川潔
- Project Period (FY)
  2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pediatrics
- Research Institution
  Hamamatsu University School of Medicine

All 2023 2022 2021 2019 2018 2017 2016 2012 2011

All Journal Article Presentation

[Journal Article] Imbalanced expression of cation-chloride cotransporters as potential therapeutic target in an Angelman syndrome model mouse.2023
- Author(s)
  Egawa K#, Watanabe M#(#contributed equally to this work), Shiraishi H, Sato D, Takahashi Y, Nishio S , Fukuda A.
- Journal Title
  
  Scientific Reports
  
  Volume: 13: 5685 Issue: 1 Pages: 5685-5685
- DOI
  10.1038/s41598-023-32376-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K06924, KAKENHI-PUBLICLY-21H05687, KAKENHI-PROJECT-21H02661, KAKENHI-PROJECT-18H02777, KAKENHI-PROJECT-23K05999, KAKENHI-PROJECT-21K07788, KAKENHI-PROJECT-19H01091
[Journal Article] Therapeutic effects of KRM-II-81, positive allosteric modulator for α2/3 subunit containing GABAA receptors, in a mouse model of Dravet syndrome2023
- Author(s)
  Nakakubo Sachiko、Hiramatsu Yasuyoshi、Goto Takeru、Kimura Syuhei、Narugami Masashi、Nakajima Midori、Ueda Yuki、Shiraishi Hideaki、Manabe Atsushi、Sharmin Dishary、Cook James M.、Egawa Kiyoshi
- Journal Title
  
  Frontiers in Pharmacology
  
  Volume: 14
- DOI
  10.3389/fphar.2023.1273633
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07930
[Journal Article] Short-latency somatosensory-evoked potentials demonstrate cortical dysfunction in patients with Angelman syndrome2021
- Author(s)
  Egawa Kiyoshi、Saitoh Shinji、Asahina Naoko、Shiraishi Hideaki
- Journal Title
  
  eNeurologicalSci
  
  Volume: 22 Pages: 100298-100298
- DOI
  10.1016/j.ensci.2020.100298
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02777
[Journal Article] Efficacy of perampanel for epileptic seizures and daily behavior in a patient with Leigh syndrome: A case report2021
- Author(s)
  Kimura Shuhei、Shiraishi Hideaki、Egawa Kiyoshi、Uchida Masaya、Ueno Michihiko
- Journal Title
  
  Brain and Development
  
  Volume: 43 Issue: 1 Pages: 157-159
- DOI
  10.1016/j.braindev.2020.07.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02777
[Journal Article] GABA from vasopressin neurons regulates the time at which suprachiasmatic nucleus molecular clocks enable circadian behavior2021
- Author(s)
  Maejima Takashi、Tsuno Yusuke、Miyazaki Shota、Tsuneoka Yousuke、Hasegawa Emi、Islam Md Tarikul、Enoki Ryosuke、Nakamura Takahiro J.、Mieda Michihiro
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 118 Issue: 6 Pages: 1-18
- DOI
  10.1073/pnas.2010168118
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07259, KAKENHI-PROJECT-20K21498, KAKENHI-PROJECT-17H04022, KAKENHI-PROJECT-19H03399, KAKENHI-PROJECT-20H03425, KAKENHI-PROJECT-17K08561, KAKENHI-PROJECT-18K06509, KAKENHI-PROJECT-18K06519, KAKENHI-PROJECT-19K06360, KAKENHI-PLANNED-20H05769, KAKENHI-PROJECT-20H05669, KAKENHI-ORGANIZER-15H05935, KAKENHI-WRAPUP-20H05615
[Journal Article] Flurothyl-induced seizure paradigm revealed higher seizure susceptibility in middle-aged Angelman syndrome mouse model2021
- Author(s)
  Egawa Kiyoshi、Nakakubo Sachiko、Kimura Shuhei、Goto Takeru、Manabe Atsushi、Shiraishi Hideaki
- Journal Title
  
  Brain and Development
  
  Volume: 43 Issue: 4 Pages: 515-520
- DOI
  10.1016/j.braindev.2020.12.011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02777
[Journal Article] Variance in the pathophysiological impact of the hemizygosity of gamma-aminobutyric acid type A receptor subunit genes between Prader-Willi syndrome and Angelman syndrome2021
- Author(s)
  Egawa Kiyoshi、Saitoh Shinji、Asahina Naoko、Shiraishi Hideaki
- Journal Title
  
  Brain and Development
  
  Volume: 43 Issue: 4 Pages: 521-527
- DOI
  10.1016/j.braindev.2020.12.014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02777
[Journal Article] Diverse Actions of Astrocytes in GABAergic Signaling.2019
- Author(s)
  Masaru Ishibashi, Kiyoshi Egawa, Atsuo Fukuda
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 20(12) Issue: 12 Pages: 1-18
- DOI
  10.3390/ijms20122964
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07284, KAKENHI-ORGANIZER-15H05871, KAKENHI-PLANNED-15H05872, KAKENHI-PROJECT-17H04025, KAKENHI-INTERNATIONAL-15K21731, KAKENHI-PROJECT-19H01091
[Journal Article] Long-term follow up of an adult with alternating hemiplegia of childhood and a p.Gly755Ser mutation in the ATP1A3 gene2018
- Author(s)
  Ito Tomoshiro、Narugami Masashi、Egawa Kiyoshi、Yamamoto Hiroyuki、Asahina Naoko、Kohsaka Shinobu、Ishii Atsushi、Hirose Shinichi、Shiraishi Hideaki
- Journal Title
  
  Brain Dev.
  
  Volume: 40 Issue: 3 Pages: 226-228
- DOI
  10.1016/j.braindev.2017.11.007
- NAID
  120006559004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K10072, KAKENHI-INTERNATIONAL-15K21731, KAKENHI-ORGANIZER-15H05871, KAKENHI-PROJECT-15H02548, KAKENHI-PROJECT-18H02777, KAKENHI-PROJECT-16K15532
[Journal Article] Chloride Dysregulation, Seizures, and Cerebral Edema: A Relationship with Therapeutic Potential2017
- Author(s)
  Joseph Glykys, Volodymyr Dzhala, Kiyoshi Egawa, Kristopher T. Kahle, Eric Delpire, Kevin Staley
- Journal Title
  
  Trends in Neuroscience
  
  Volume: 40 Issue: 5 Pages: 276-294
- DOI
  10.1016/j.tins.2017.03.006
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-INTERNATIONAL-15K21731, KAKENHI-ORGANIZER-15H05871, KAKENHI-PROJECT-15K09611
[Presentation] Therapeutic effects of KRM-II-81, positive allosteric modulator for α2/3 subunit containing GABAA receptor, in mice model of Dravet syndrome.2023
- Author(s)
  江川潔
- Organizer
  FENS Regional Meeting 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07930
[Presentation] Dravet症候群マウスにおけるα2/3サブユニット選択的GABAA受容体賦活薬の効果2022
- Author(s)
  中久保佐千子(研究協力者）、江川潔
- Organizer
  第28回日本てんかん学会北海道地方会
- Data Source
  KAKENHI-PROJECT-22K07930
[Presentation] Imbalanced Tonic Inhibition Between the Cortex and Thalamus Causes Epileptiform Activity in Mice Model of Angelman Syndrome.2019
- Author(s)
  Egawa K, Shiraishi H, Savic M, Li G, Cook J.
- Organizer
  American Epilepsy Society, 63th Scientific meeting,
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02777
[Presentation] Electrophysiological properties of excitatory or inhibitory neurons derived from induced pluripotent stem cells (iPSC) in Angelman syndrome.2019
- Author(s)
  Kiyoshi Egawa, Yoshihiro Hirata, Mitsuru Ishikawa, Hideaki Siraishi, Shinji Saito, Yukitoshi Takahasi, Hironobu Okuno, Hideyuki Okano
- Organizer
  The 20th Annual Meeting of Infantile Seizure Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02777
[Presentation] 遺伝性てんかん・発達障害動物モデルにおける認知機能評価の難しさ ―アンジェルマン症候群モデルマウスにおける経験―2019
- Author(s)
  江川潔
- Organizer
  第５３回日本てんかん学会総会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02777
[Presentation] Pathophysiological impact of diverse dysregulation of tonic inhibition in Angelman syndrome2019
- Author(s)
  Kiyoshi Egawa and Atuo Fukuda
- Organizer
  The 9th Federation of Asian and Oceanian Physiological Societies Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02777
[Presentation] アンジェルマン症候群患者由来iPS細胞より誘導された興奮性／抑制性神経細胞の機能解析2018
- Author(s)
  平田快洋、石川充、白石秀明、佐藤大介、斎藤伸治、高橋幸利、奥野博庸、岡野栄之、江川潔
- Organizer
  第41回日本神経科学学会
- Data Source
  KAKENHI-PROJECT-18H02777
[Presentation] アンジェルマン症候群患者iPS細胞由来ニューロンの電気生理学的検討2018
- Author(s)
  江川潔、平田快洋、白石秀明、佐藤大介、齋藤伸治、高橋幸利、奥野博庸、石川充、岡野栄之
- Organizer
  第60回日本小児神経学会
- Data Source
  KAKENHI-PROJECT-18H02777
[Presentation] Deregulated tonic inhibition in the hippocampus of mice model of Angelman syndrome2017
- Author(s)
  江川潔　河野修
- Organizer
  １４ｔｈAsian and Oceanian Congress of Child Neurology
- Place of Presentation
  ヒルトン福岡シーホーク（福岡県福岡市）
- Year and Date
  2017-05-11
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09611
[Presentation] Diverse deregulation of tonic inhibition in thalamo‐cortical networks of mice model of Angelman syndrome.2017
- Author(s)
  江川潔
- Organizer
  第51回日本てんかん学会京都府京都市
- Data Source
  KAKENHI-PROJECT-15K09611
[Presentation] Aberrant oscillation property of Perkinje cells is caused by decreased tonic inhibitionin granule in granule cells in mice model of Angelman syndrome.2016
- Author(s)
  Egawa, K. and Fukuda, A.
- Organizer
  第93回日本生理学会大会
- Place of Presentation
  札幌コンベンションセンター（北海道・札幌市）
- Year and Date
  2016-03-23
- Data Source
  KAKENHI-PLANNED-15H05872
[Presentation] Aberrant oscillation property of Perkinje cells is caused by decreased tonic inhibition in granule cells in mice model of Angelman syndrome.2016
- Author(s)
  江川潔　福田敦夫
- Organizer
  日本生理学会総会
- Place of Presentation
  札幌コンベンションセンター（北海道札幌市）
- Year and Date
  2016-03-22
- Data Source
  KAKENHI-PROJECT-15K09611
[Presentation] Regionally differential calcium oscillation of radially migrating cells in embryonic cortex2012
- Author(s)
  Nakanishi, Y., Kumada, T., Furukawa, T., Egawa, K. and Fukuda, A.
- Organizer
  第89回日本生理学会大会
- Place of Presentation
  長野
- Data Source
  KAKENHI-PROJECT-23659535
[Presentation] Impairment of tonic inhibition in cerebellum granule cells causes cerebellum dysfunction in Ube3a maternal-deficient mice2011
- Author(s)
  Egawa, K., Inoue, K., Saitoh, S., Kishino, T. and Fukuda, A.
- Organizer
  41st Annual Meeting, Society for Neuroscience
- Place of Presentation
  Washington, D. C., U. S. A.
- Data Source
  KAKENHI-PROJECT-23659535
[Presentation] GABAergic dysfunction in Ube3a deficient mice, models of angelman syndrome2011
- Author(s)
  Egawa, K., Inoue, K., Saitoh, S., Kishino, T. and Fukuda, A.
- Organizer
  第34回日本神経科学大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23659535
[Presentation] Impairment of tonic inhibition in cerebellum granule cells causes cerebellumdysfunction in Ube3a maternal-deficient mice2011
- Author(s)
  Egawa, K., et al
- Organizer
  41st Annual Meeting, Society for Neuroscience
- Place of Presentation
  Washington, D.C., USA
- Data Source
  KAKENHI-PROJECT-23659535
[Presentation] アンジェルマン症候群における小脳顆粒細胞tonic inhibitionの低下と小脳機能障害2011
- Author(s)
  江川潔,井上浩一,斉藤伸治,木住野達也,福田敦夫
- Organizer
  第38回日本脳科学会
- Place of Presentation
  沖縄
- Data Source
  KAKENHI-PROJECT-23659535
[Presentation] Impairment of tonic inhibition in cerebellum granule cells causes cerebellum dysfunction in Ube3a maternal-deficient mice2011
- Author(s)
  Egawa, K., Inoue, K., Saitoh, S., Kishino, T. and Fukuda, A.
- Organizer
  Angelman Syndrome Foundation Scientific Symposium
- Place of Presentation
  Salt Lake City, U. S. A.
- Data Source
  KAKENHI-PROJECT-23659535
[Presentation] Impairment of tonic inhibition in cerebellum granule cells causes cerebellum dysfunction in Ube3a maternal-deficient mice2011
- Author(s)
  江川潔
- Organizer
  Neuroscience 2011
- Place of Presentation
  アメリカ合衆国ワシントン
- Year and Date
  2011-11-15
- Data Source
  KAKENHI-PROJECT-23791166
[Presentation] Ube3a機能欠失マウス(アンジェルマン症候群モデルマウス)におけるGABA作動性抑制機能障害の検討2011
- Author(s)
  江川潔
- Organizer
  第34回日本神経科学大会総会
- Place of Presentation
  横浜
- Year and Date
  2011-09-16
- Data Source
  KAKENHI-PROJECT-23791166
[Presentation] Impairment of tonic inhibition in cerebellum granule cells causes cerebellum dysfunction in Ube3a maternal-deficient mice2011
- Author(s)
  Egawa, K., et al
- Organizer
  Angelman Syndrome Foundation Scientific Symposium
- Place of Presentation
  Sheraton Salt Lake City, USA
- Data Source
  KAKENHI-PROJECT-23659535
[Presentation] 発達期の大脳皮質の各領域における移動細胞のカルシウム振動2011
- Author(s)
  中西康彦,福田敦夫,熊田竜郎,古川智範,江川潔
- Organizer
  第58回中部生理学会
- Place of Presentation
  福井
- Data Source
  KAKENHI-PROJECT-23659535
[Presentation] アンジェルマン症候群における小脳顆粒細胞tonic inhibitionの低下と小脳機能障害2011
- Author(s)
  江川潔,井上浩一,斉藤伸治,木住野達也,福田敦夫
- Organizer
  平成23年度生理学研究会シナプス2011
- Place of Presentation
  岡崎
- Data Source
  KAKENHI-PROJECT-23659535

1. FUKUDA Atsuo (50254272)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
2. INOUE Koichi (80345818)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
3. HATA Kenichiro (60360335)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. Enoki Ryosuke (00528341)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 柳川右千夫 (90202366)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 岡野栄之 (60160694)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
7. KAWANO Osamu

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. SHIRAISHI Hideaki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 渡部美穂

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 石橋賢

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 津野祐輔

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Egawa Kiyoshi 江川 潔

EGAWA Kiyoshi 江川 潔

Research Projects

Research Products

Co-Researchers

遺伝性自閉スペクトラム症における肥満の病態生理－疾患モデルマウスによる解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

ドラベ症候群におけるα2サブユニット選択的GABA(A)受容体賦活薬の有効性検証Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Why is the circadian rhythm center composed of GABAergic neurons?

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Pathophysiological impact of diverse deregulation of tonic inhibition in Angelman syndromePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mechanisms and therapeutic strategy for cognitive dysfunction in Angelman syndromePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Modal shifts in cellular and network oscillations

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Perturbation of developmental Cl^-homeodynamics may underlie fetal and neonatal brain disorders

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

アンジェルマン症候群モデルマウスにおける小脳機能障害の電気生理学的検討Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Imbalanced expression of cation-chloride cotransporters as potential therapeutic target in an Angelman syndrome model mouse.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Therapeutic effects of KRM-II-81, positive allosteric modulator for α2/3 subunit containing GABAA receptors, in a mouse model of Dravet syndrome2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Short-latency somatosensory-evoked potentials demonstrate cortical dysfunction in patients with Angelman syndrome2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Efficacy of perampanel for epileptic seizures and daily behavior in a patient with Leigh syndrome: A case report2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] GABA from vasopressin neurons regulates the time at which suprachiasmatic nucleus molecular clocks enable circadian behavior2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Flurothyl-induced seizure paradigm revealed higher seizure susceptibility in middle-aged Angelman syndrome mouse model2021

Author(s)

Egawa Kiyoshi 江川潔

EGAWA Kiyoshi 江川潔