Higashi Kenjirou 東顕二郎

… Alternative Names

HIGASHI Kenjirou 東顕二郎

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Researcher Number	40451760
Other IDs
Affiliation (Current)	2025: 千葉大学, 大学院薬学研究院, 准教授
Affiliation (based on the past Project Information) *help	2017 – 2024: 千葉大学, 大学院薬学研究院, 准教授 2015 – 2016: 千葉大学, 大学院薬学研究院, 講師 2014 – 2015: 千葉大学, 薬学研究科(研究院), 講師 2014: 千葉大学, 大学院薬学研究院, 助教 2011 – 2013: 千葉大学, 薬学研究科(研究院), 助教 2009 – 2012: Chiba University, 大学院・薬学研究院, 助教
Review Section/Research Field	Principal Investigator Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related / Physical pharmacy Except Principal Investigator Physical pharmacy / Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related / Basic Section 28010:Nanometer-scale chemistry-related / Medical pharmacy
Keywords	Principal Investigator 安定性 / ナノ粒子 / 難水溶性薬物 / 非晶質 / NMR / 分子間相互作用 / 運動性 / 固体NMR / 吸収性 / cryo-TEM … More / suspended-state NMR / 非晶質ナノ粒子 / Cryo-TEM / 湿式粉砕 / 固液界面 / 溶解性改善 / 溶解性 / suspended state NMR / 中分子薬物 / 界面 / 表面エネルギー / STEM-EDX / 安定化 / 界面活性剤 / 非晶質固体分散体 / Poloxamer / Indometacin / 分散安定性 / 表面構造 / ナノ懸濁液 / poloxamer / piroxicam / indomethacin / 多形 / 薬物ナノ粒子 / Suspended state NMR / 結晶多形 / 薬物ナノ懸濁液 / メフェナム酸 / In situ測定 / suspended state NMR法 / RFDR / NOESY / 過飽和溶液 / 緩和時間 / ELSD / 固体ＮＭＲ / 溶出速度 / 相溶性 / HRMAS / Eudragit / 固体分散体 / PXRD / 分子状態 / 金属塩 / Solid State NMR / NMR緩和時間 / 単結晶X線構造解析 / ナプロキセンNa / 水和物・擬似多形 / 医薬品金属塩 / 水和物 / 低含量製剤 / MQ-MAS NMR … More Except Principal Investigator NMR / 溶解性改善 / 難水溶性薬物 / Cryo-TEM / 脂質ナノ粒子 / AFM / ポリマー / 過飽和 / 放出制御 / 非晶質 / 固体分散体 / 有機ナノチューブ / 分子状態 / 原子間力顕微鏡 / 相互作用 / メゾスケール凝集 / 相互作用ポテンシャル / 不均一凝集 / 小角散乱 / ペアポテンシャル / 治療薬徐放作用 / 高分子ナノミセル / 液-液相分離 / 薬物濃縮相 / 溶解 / SAXS / 運動性 / 小角X線散乱 / 薬学 / 構造解析 / 脂質構造体 / 安定性 / DDS / バイセル / ナノ / 液中測定 / 原子間力顕微鏡（AFM / 透過型電子顕微鏡（TEM） / 構造評価 / 力学特性 / ナノ粒子 / 原子間力顕微鏡（AFM） / 結晶多形 / 薬物封入 / ポリシュードロタキサン / ナノチューブ / 分子間相互作用 / 溶出速度 / 超分子複合体 / 固体NMR / 薬物溶解性 / シクロデキストリン / 分子製剤学 / 固体分散体過飽和 / 刺激応答性 / 経口製剤 / 構溶液造 / 可溶化 / ナノ微粒子 / 溶液 / テラヘルツ / 溶液構造 Less

Elucidation of destabilization mechanism of drug amorphous nanosuspension for middle-molecule drug developmentPrincipal Investigator
- Principal Investigator
  
  東顕二郎
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
- Research Institution
  Chiba University
Development of drug-rich phase-coexisting lipid nanoparticle formulations based on elucidation of molecular mechanism of liquid-liquid phase separation phenomenon of drugs
- Principal Investigator
  
  植田圭祐
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
- Research Institution
  Chiba University
Study on the origin of sustained drug releasability of polymeric nanomicelles based on clarifying the interaction potential surface
- Principal Investigator
  
  森田剛
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 28010:Nanometer-scale chemistry-related
- Research Institution
  Chiba University
Structural evaluation of solid-liquid interface of drug nanoamorphous by suspended-state NMRPrincipal Investigator
- Principal Investigator
  
  Higashi Kenjirou
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
- Research Institution
  Chiba University
Drug dissolution mechanism based on evaluation of polymer structure, mobility, and intermolecular interaction
- Principal Investigator
  
  Moribe Kunikazu
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
- Research Institution
  Chiba University
Design of drug amorphous nanosuspension to achieve a pharmaceutical formulation of poorly water-soluble drugPrincipal Investigator
- Principal Investigator
  
  Higashi Kenjirou
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
- Research Institution
  Chiba University
Pharmaceutical application of novel lipid nanocarrier bicelle
- Principal Investigator
  
  Itai Shigeru
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  University of Shizuoka
Refined structural analysis and mechanical property of drug nano-formulation by AFM in aqueous meida
- Principal Investigator
  
  MORIBE KUNIKAZU
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Chiba University
Evaluation of molecular state of drug nanosuspensions by suspended-state NMR spectroscopyPrincipal Investigator
- Principal Investigator
  
  Higashi Kenjirou
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Chiba University
Design of supramolecular complexes to form asymmetry nanotube structure and the application for controlled release carrier
- Principal Investigator
  
  Yamamoto Keiji
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Chiba University
Structure of supersaturated solution of poorly water-soluble drug indexed by mobility and diffusibility and the correlation with membrane permeability
- Principal Investigator
  
  MORIBE Kunikazu
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Chiba University
In situ suspended state NMR investigation into a solid dipersion after dispersed into waterPrincipal Investigator
- Principal Investigator
  
  KENJIROU Higashi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  Chiba University
Encapsulation of a poorly water-soluble drug with large molecular size into organic nanotube
- Principal Investigator
  
  YAMAMOTO Keiji
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Physical pharmacy
- Research Institution
  Chiba University
Structural evaluation of drug solution by ATR terahertz, NMR, DSC, and viscometry
- Principal Investigator
  
  MORIBE Kunikazu
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Chiba University
Evaluation of crystal and molecular state of pharmaceutical salt by MQ-MAS NMR methodPrincipal Investigator
- Principal Investigator
  
  HIGASHI Kenjirou
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  Chiba University

[Book] NMRによる有機材料分析とその試料前処理、データ解析2021
- Author(s)
  東　顕二郎（共著）
- Total Pages
  10
- Publisher
  技術情報協会
- ISBN
  9784861048609
- Data Source
  KAKENHI-PROJECT-21K06509
[Book] ナノ・マイクロ微粒子の分散評価技術　核磁気共鳴（分担）2020
- Author(s)
  東　顕二郎、植田　圭祐、森部　久仁一　（分担）
- Total Pages
  227
- Publisher
  シーエムシー出版
- ISBN
  9784781314907
- Data Source
  KAKENHI-PROJECT-18K06592
[Book] 粉体の表面処理・複合化技術集大成2018
- Author(s)
  東顕二郎、植田圭祐、森部久仁一　分担執筆、内藤　牧男　監修
- Total Pages
  752
- Publisher
  テクノシステム
- ISBN
  9784924728813
- Data Source
  KAKENHI-PROJECT-18K06592
[Book] 最新製剤学　第11版2018
- Author(s)
  東顕二郎、分担執筆、尾関哲也、井上勝央　編集
- Total Pages
  527
- Publisher
  廣川書店
- ISBN
  4567480279
- Data Source
  KAKENHI-PROJECT-18K06592
[Book] 固体医薬品の物性評価　第2版2018
- Author(s)
  東顕二郎　分担執筆、日本薬剤学会物性FG　監修
- Total Pages
  413
- Publisher
  じほう
- ISBN
  4840751072
- Data Source
  KAKENHI-PROJECT-18K06592
[Book] 難水溶性薬物の経口製剤化技術最前線2016
- Author(s)
  東顕二郎,　森部　久仁一
- Total Pages
  14
- Publisher
  シーエムシー出版
- Data Source
  KAKENHI-PROJECT-15K07885
[Book] ナノ結晶化技術の基礎と医薬品開発の現状, 難水溶性薬物の経口製剤化技術最前線2016
- Author(s)
  東顕二郎, 森部久仁一（分担）
- Publisher
  シーエムシー出版
- Data Source
  KAKENHI-PROJECT-16K08190
[Book] 固体NMR法、薬剤学実験法必携マニュアル-物理薬剤学2014
- Author(s)
  東顕二郎他
- Total Pages
  345
- Publisher
  南山堂
- Data Source
  KAKENHI-PROJECT-24790041
[Book] 医薬ジャーナル：各種ポリマーによる難水溶性薬物の溶解性改善機構の解明と製剤化への応用 (特集実用可能な新しい製剤技術の進歩と将来展望)2014
- Author(s)
  植田圭祐, 東顕二郎, 森部久仁一
- Total Pages
  256
- Publisher
  医薬ジャーナル社
- Data Source
  KAKENHI-PROJECT-24590045
[Journal Article] Mechanistic Analysis of Temperature-Dependent Curcumin Release from Poly(lactic-co-glycolic acid)/Poly(lactic acid) Polymer Nanoparticles2024
- Author(s)
  Sunazuka Yushi、Ueda Keisuke、Higashi Kenjirou、Wada Koichi、Moribe Kunikazu
- Journal Title
  
  Molecular Pharmaceutics
  
  Volume: 21 Issue: 3 Pages: 1424-1435
- DOI
  10.1021/acs.molpharmaceut.3c01066
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K06545
[Journal Article] Quantitative Investigation of Intestinal Drug Absorption Enhancement by Drug-Rich Nanodroplets Generated via Liquid?Liquid Phase Separation2024
- Author(s)
  Yoshikawa Etsushi、Ueda Keisuke、Hakata Rei、Higashi Kenjirou、Moribe Kunikazu
- Journal Title
  
  Molecular Pharmaceutics
  
  Volume: 21 Issue: 4 Pages: 1745-1755
- DOI
  10.1021/acs.molpharmaceut.3c01078
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K06545
[Journal Article] Understanding the rod-to-tube transformation of self-assembled ascorbyl dipalmitate lipid nanoparticles stabilized with PEGylated lipids2023
- Author(s)
  Chen Ziqiao、Higashi Kenjirou、Shigehisa Yuki、Ueda Keisuke、Yamamoto Keiji、Moribe Kunikazu
- Journal Title
  
  Nanoscale
  
  Volume: 15 Issue: 6 Pages: 2602-2613
- DOI
  10.1039/d2nr04987b
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K06545
[Journal Article] Vapor-Phase-Mediated Encapsulation of Guest Drug Molecules in the Hexagonal Columnar Form Structure of Polyethylene Glycol/γ-Cyclodextrin-Polypseudorotaxane2023
- Author(s)
  Kundu Sudeshna、Higashi Kenjirou、Takamizawa Makoto、Ueda Keisuke、Moribe Kunikazu
- Journal Title
  
  Crystal Growth & Design
  
  Volume: 23 Issue: 8 Pages: 6119-6129
- DOI
  10.1021/acs.cgd.3c00619
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K06545
[Journal Article] Modification of liposomes composed of a cationic lipid TMAG and an anionic lipid DSPG with a PEGylated lipid based on the investigation of lipid structures2023
- Author(s)
  Hohokabe Miyuki、Higashi Kenjirou、Yamada Yurina、Fujimoto Taiki、Tokumoto Taisei、Imamura Hiroshi、Morita Takeshi、Ueda Keisuke、Limwikrant Waree、Moribe Kunikazu
- Journal Title
  
  Colloids and Surfaces A: Physicochemical and Engineering Aspects
  
  Volume: 661 Pages: 130891-130891
- DOI
  10.1016/j.colsurfa.2022.130891
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06503, KAKENHI-PROJECT-22K06545, KAKENHI-PROJECT-23K23156
[Journal Article] Molecular-Level Structural Analysis of siRNA-Loaded Lipid Nanoparticles by <sup>1</sup>H NMR Relaxometry: Impact of Lipid Composition on Their Structural Properties2023
- Author(s)
  Ueda Keisuke、Sakagawa Yui、Saito Tomoki、Fujimoto Taiki、Nakamura Misaki、Sakuma Fumie、Kaneko Shun、Tokumoto Taisei、Nishimura Koki、Takeda Junpei、Arai Yuta、Yamamoto Katsuhiko、Ikeda Yukihiro、Higashi Kenjirou、Moribe Kunikazu
- Journal Title
  
  Molecular Pharmaceutics
  
  Volume: 20 Issue: 9 Pages: 4729-4742
- DOI
  10.1021/acs.molpharmaceut.3c00477
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K06545
[Journal Article] Preparation of a ternary amorphous solid dispersion using hot-melt extrusion for obtaining a stable colloidal dispersion of amorphous probucol nanoparticles2023
- Author(s)
  Hanada Naho、Higashi Kenjirou、Zhao Zhijing、Ueda Keisuke、Moribe Kunikazu
- Journal Title
  
  International Journal of Pharmaceutics
  
  Volume: 640 Pages: 122959-122959
- DOI
  10.1016/j.ijpharm.2023.122959
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K06545, KAKENHI-PROJECT-21K06509
[Journal Article] Ready-to-Use-Type Lyophilized Lipid Nanoparticle Formulation for the Postencapsulation of Messenger RNA2023
- Author(s)
  Tanaka Hiroki、Hagiwara Shinya、Shirane Daiki、Yamakawa Takuma、Sato Yuka、Matsumoto Chika、Ishizaki Kota、Hishinuma Miho、Chida Katsuyuki、Sasaki Kasumi、Yonemochi Etsuo、Ueda Keisuke、Higashi Kenjirou、Moribe Kunikazu、Tadokoro Takashi、Maenaka Katsumi、Taneichi Sakura、et al.
- Journal Title
  
  ACS Nano
  
  Volume: 17 Issue: 3 Pages: 2588-2601
- DOI
  10.1021/acsnano.2c10501
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K06545, KAKENHI-PROJECT-21K18320, KAKENHI-PROJECT-21K18035
[Journal Article] Supersaturation maintenance of carvedilol and chlorthalidone by cyclodextrin derivatives: Pronounced crystallization inhibition ability of methylated cyclodextrin2023
- Author(s)
  Liu Mengyao、Higashi Kenjirou、Ueda Keisuke、Moribe Kunikazu
- Journal Title
  
  International Journal of Pharmaceutics
  
  Volume: 637 Pages: 122876-122876
- DOI
  10.1016/j.ijpharm.2023.122876
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K06509, KAKENHI-PROJECT-22K06545
[Journal Article] Quantitative Analysis of Drug Supersaturation Region by Temperature-Variable Nuclear Magnetic Resonance Measurements, Part 2: Effects of Solubilizer2023
- Author(s)
  Ueda Keisuke、Higashi Kenjirou、Moribe Kunikazu
- Journal Title
  
  Molecular Pharmaceutics
  
  Volume: 20 Issue: 4 Pages: 1872-1883
- DOI
  10.1021/acs.molpharmaceut.3c00050
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K06545
[Journal Article] 添加剤による難水溶性薬物の溶解性改善～基礎理論と最近の研究紹介～2023
- Author(s)
  東顕二郎、植田圭祐、森部久仁一
- Journal Title
  
  Pharm Tech Japan
  
  Volume: 39(4) Pages: 597-605
- Data Source
  KAKENHI-PROJECT-21K06509
[Journal Article] Quantitative Analysis of Drug Supersaturation Region by Temperature-Variable Nuclear Magnetic Resonance Measurements, Part 1: Effects of Polymer and Drug Chiralities2023
- Author(s)
  Ueda Keisuke、Higashi Kenjirou、Moribe Kunikazu
- Journal Title
  
  Molecular Pharmaceutics
  
  Volume: 20 Issue: 4 Pages: 1861-1871
- DOI
  10.1021/acs.molpharmaceut.2c00924
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K06545
[Journal Article] NMR-Based Mechanistic Study of Crystal Nucleation Inhibition in a Supersaturated Drug Solution by Polyvinylpyrrolidone2022
- Author(s)
  Ueda Keisuke、Yamamoto Neo、Higashi Kenjirou、Moribe Kunikazu
- Journal Title
  
  Crystal Growth & Design
  
  Volume: 22 Issue: 5 Pages: 3235-3244
- DOI
  10.1021/acs.cgd.2c00084
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K06545
[Journal Article] Multistep Crystallization of Pharmaceutical Amorphous Nanoparticles via a Cognate Pathway of Oriented Attachment: Direct Evidence of Nonclassical Crystallization for Organic Molecules2022
- Author(s)
  Chen Ziqiao、Higashi Kenjirou、Ueda Keisuke、Moribe Kunikazu
- Journal Title
  
  Nano Letters
  
  Volume: 22 Issue: 16 Pages: 6841-6846
- DOI
  10.1021/acs.nanolett.2c01608
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K06509, KAKENHI-PROJECT-22K06545
[Journal Article] A study combining magic-angle spinning NMR and small-angle X-ray scattering on the interaction in the mixture of poly(benzyl methacrylate) and ionic liquid 1-ethyl-3-methylimidazolium bis(trifluoromethanesulfonyl)amide2022
- Author(s)
  Morita Takeshi、Okada Hitomi、Yamada Taisei、Hidaka Ryo、Ueki Takeshi、Niitsuma Kazuyuki、Kitazawa Yuzo、Watanabe Masayoshi、Nishikawa Keiko、Higashi Kenjirou
- Journal Title
  
  Physical Chemistry Chemical Physics
  
  Volume: 24 Issue: 43 Pages: 26575-26582
- DOI
  10.1039/d2cp02207a
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H02671, KAKENHI-PROJECT-20H02804, KAKENHI-PROJECT-20K21229, KAKENHI-PROJECT-23K23156
[Journal Article] Computational approach to elucidate the formation and stabilization mechanism of amorphous formulation using molecular dynamics simulation and fragment molecular orbital calculation2022
- Author(s)
  Ma Xiaohan、Higashi Kenjirou、Fukuzawa Kaori、Ueda Keisuke、Kadota Kazunori、Tozuka Yuichi、Yonemochi Etsuo、Moribe Kunikazu
- Journal Title
  
  International Journal of Pharmaceutics
  
  Volume: 615 Pages: 121477-121477
- DOI
  10.1016/j.ijpharm.2022.121477
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K06509, KAKENHI-PROJECT-22K06545
[Journal Article] Preparation of redispersible dry nanoemulsion using chitosan-octenyl succinic anhydride starch polyelectrolyte complex as stabilizer2022
- Author(s)
  Sodalee Kun、Limwikrant Waree、Pongjanyakul Thaned、Ueda Keisuke、Higashi Kenjirou、Moribe Kunikazu、Puttipipatkhachorn Satit
- Journal Title
  
  Journal of Drug Delivery Science and Technology
  
  Volume: 73 Pages: 103433-103433
- DOI
  10.1016/j.jddst.2022.103433
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K06545
[Journal Article] Drug-Loaded Nanocarriers Composed of Cholesteryl Oleate Crystal Cores and Multiple-Nanosheet Shells of γ-Cyclodextrin Inclusion Complex Crystals2022
- Author(s)
  Ishimoto Arisa、Sasako Hiroshi、Omori Masaki、Higashi Kenjirou、Ueda Keisuke、Koyama Kazuo、Moribe Kunikazu
- Journal Title
  
  Langmuir
  
  Volume: 38 Issue: 34 Pages: 10454-10464
- DOI
  10.1021/acs.langmuir.2c01199
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K06545
[Journal Article] Unusual Correlation between the Apparent Amorphous Solubility of a Drug and Solubilizer Concentration Revealed by NMR Analysis2022
- Author(s)
  Ueda Keisuke、Higashi Kenjirou、Moribe Kunikazu
- Journal Title
  
  Molecular Pharmaceutics
  
  Volume: 19 Issue: 9 Pages: 3336-3349
- DOI
  10.1021/acs.molpharmaceut.2c00478
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K06545
[Journal Article] Nanostructure and Molecular-Level Characterization of Aminoalkyl Methacrylate Copolymer and the Impact on Drug Solubilization Ability2021
- Author(s)
  Okamoto Yuta、Higashi Kenjirou、Morita Takeshi、Ueda Keisuke、Mukaide Sayaka、Takeda Junpei、Karashima Masatoshi、Ikeda Yukihiro、Moribe Kunikazu
- Journal Title
  
  Molecular Pharmaceutics
  
  Volume: 18 Issue: 11 Pages: 4111-4121
- DOI
  10.1021/acs.molpharmaceut.1c00526
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16334, KAKENHI-PROJECT-20K06985
[Journal Article] 固体NMRによる医薬品原薬・製剤の評価2021
- Author(s)
  東顕二郎
- Journal Title
  
  Pharm Stage
  
  Volume: 20(10) Pages: 59-64
- NAID
  40022464832
- Data Source
  KAKENHI-PROJECT-18K06592
[Journal Article] Transition from Amorphous Cyclosporin A Nanoparticles to Size-Reduced Stable Nanocrystals in a Poloxamer 407 Solution2021
- Author(s)
  Chen Ziqiao、Higashi Kenjirou、Ueda Keisuke、Moribe Kunikazu
- Journal Title
  
  Molecular Pharmaceutics
  
  Volume: 19 Issue: 1 Pages: 188-199
- DOI
  10.1021/acs.molpharmaceut.1c00721
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16334, KAKENHI-PROJECT-21K06509
[Journal Article] Revealing the mechanism of morphological variation of amorphous drug nanoparticles formed by aqueous dispersion of ternary solid dispersion2021
- Author(s)
  Zhao Zhijing、Higashi Kenjirou、Ueda Keisuke、Moribe Kunikazu
- Journal Title
  
  International Journal of Pharmaceutics
  
  Volume: 607 Pages: 120984-120984
- DOI
  10.1016/j.ijpharm.2021.120984
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16334, KAKENHI-PROJECT-21K06509
[Journal Article] 固体NMRの原薬・製剤評価への応用2020
- Author(s)
  東顕二郎
- Journal Title
  
  Farumashia
  
  Volume: 56 Issue: 8 Pages: 739-743
- DOI
  10.14894/faruawpsj.56.8_739
- NAID
  130007883599
- ISSN
  0014-8601, 2189-7026
- Language
  Japanese
- Data Source
  KAKENHI-PROJECT-18K06592
[Journal Article] Clarification of the Dissolution Mechanism of an Indomethacin/Saccharin/Polyvinylpyrrolidone Ternary Solid Dispersion by NMR Spectroscopy2020
- Author(s)
  Kosaka Mami、Higashi Kenjirou、Nishimura Misaki、Ueda Keisuke、Moribe Kunikazu
- Journal Title
  
  Journal of Pharmaceutical Sciences
  
  Volume: 109 Issue: 12 Pages: 3617-3624
- DOI
  10.1016/j.xphs.2020.09.009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K06985, KAKENHI-PROJECT-19K16334
[Journal Article] Cryo-TEM and AFM Observation of the Time-Dependent Evolution of Amorphous Probucol Nanoparticles Formed by the Aqueous Dispersion of Ternary Solid Dispersions.2019
- Author(s)
  Zhao Z, Katai H, Higashi K, Ueda K, Kawakami K, Moribe K
- Journal Title
  
  Mol Pharm
  
  Volume: 印刷中 Issue: 5 Pages: 2184-2198
- DOI
  10.1021/acs.molpharmaceut.9b00158
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08190, KAKENHI-PROJECT-18K06592, KAKENHI-PROJECT-19K16334
[Journal Article] Nano-scale and molecular-level understanding of wet-milled indomethacin/poloxamer 407 nanosuspension with TEM, suspended-state NMR, and Raman measurements2018
- Author(s)
  Kuroiwa Yosuke、Higashi Kenjirou、Ueda Keisuke、Yamamoto Keiji、Moribe Kunikazu
- Journal Title
  
  International journal of pharmaceutics
  
  Volume: 537 Issue: 1-2 Pages: 30-39
- DOI
  10.1016/j.ijpharm.2017.12.028
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K07885
[Journal Article] Determination of Nonspherical Morphology of Doxorubicin-Loaded Liposomes by Atomic Force Microscopy.2018
- Author(s)
  Takahashi N, Higashi K, Ueda K, Yamamoto K, Moribe K.
- Journal Title
  
  J Pharm Sci.
  
  Volume: 107 Issue: 2 Pages: 717-726
- DOI
  10.1016/j.xphs.2017.10.009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08190
[Journal Article] Morphological and physicochemical evaluation of two distinct glibenclamide/hypromellose amorphous nanoparticles prepared by the antisolvent method.2018
- Author(s)
  Yonashiro, H., Higashi, K., Morikawa, C., Ueda, K., Itoh, T., Ito, M., Masu, H., Noguchi, S., Moribe, K.
- Journal Title
  
  Molecular Pharamceutics
  
  Volume: 15（4） Issue: 4 Pages: 1587-1597
- DOI
  10.1021/acs.molpharmaceut.7b01122
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06592
[Journal Article] Combination of Roll Grinding and High-Pressure Homogenization Can Prepare Stable Bicelles for Drug Delivery2018
- Author(s)
  Matsuo S, Higashi K, Moribe K, Kimura SI, Itai S, Kondo H, Iwao Y
- Journal Title
  
  Nanomaterials (Basel)
  
  Volume: 8 Issue: 12 Pages: 998-998
- DOI
  10.3390/nano8120998
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08455
[Journal Article] A solid-phase mediated methodology to incorporate drug into intermolecular spaces of CD columns in the PEG/CD-polypseudorotaxanes by cogrinding and subsequent heating2017
- Author(s)
  Ogawa, M., Higashi, K., Namiki, S., Liu, N. Ueda, K., Limwikrant, W., Yamamoto, K., Moribe, K.
- Journal Title
  
  Cryst. Growth Des.
  
  Volume: 17(3) Issue: 3 Pages: 1055-1068
- DOI
  10.1021/acs.cgd.6b01410
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07885
[Journal Article] Effect of guest drug character encapsulated in the cavity and intermolecular spaces of γ-cyclodextrins on the dissolution property of ternary γ-cyclodextrin complex2017
- Author(s)
  Liu Nan、Higashi Kenjirou、Ueda Keisuke、Moribe Kunikazu
- Journal Title
  
  International journal of pharmaceutics
  
  Volume: 531 Issue: 2 Pages: 543-549
- DOI
  10.1016/j.ijpharm.2017.04.049
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K07885
[Journal Article] Structural elucidation of a novel transglycosylated compound α-glucosyl rhoifolin and of α-glucosyl rutin by NMR spectroscopy2017
- Author(s)
  Aoki Chisa、Takeuchi Yoshihiro、Higashi Kenjirou、Okamoto Yuta、Nakanishi Akihito、Tandia Mahamadou、Uzawa Jun、Ueda Keisuke、Moribe Kunikazu
- Journal Title
  
  Carbohydrate Research
  
  Volume: 443-444 Pages: 37-41
- DOI
  10.1016/j.carres.2017.03.011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K07885
[Journal Article] Composition-dependent structural changes and antitumor activity of ASC-DP/DSPE-PEG nanoparticles.2016
- Author(s)
  Higashi, K., Mibu, F., Saito, K., Limwikrant, W., Yamamoto, K., Moribe, K.
- Journal Title
  
  Eur. J. Pharm. Sci.
  
  Volume: 99 Pages: 24-31
- DOI
  10.1016/j.ejps.2016.11.029
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08190
[Journal Article] Molecular-level understanding of the encapsulation and dissolution of poorly water-soluble ibuprofen by functionalized organic nanotubes using solid-state NMR spectroscopy.2016
- Author(s)
  Liu, N., Higashi, K., Kikuchi, J., Ando, S., Kameta, N., Ding, W., Masuda, M., Shimizu, T., Ueda, K., Yamamoto, K., Moribe, K.
- Journal Title
  
  J. Phys. Chem B
  
  Volume: 120(19) Issue: 19 Pages: 4496-4507
- DOI
  10.1021/acs.jpcb.6b00939
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K07885
[Journal Article] Crystallization of probucol in nanoparticles revealed by AFM analysis in aqueous solution2015
- Author(s)
  Egami, K., Higashi, K., Yamamoto, K., Moribe, K.
- Journal Title
  
  Molecular Pharmaceutics
  
  Volume: 12 (8) Issue: 8 Pages: 2972-2980
- DOI
  10.1021/acs.molpharmaceut.5b00236
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K07885
[Journal Article] Direct evaluation of molecular states of piroxicam/poloxamer nanosuspension by suspended-state NMR and Raman spectroscopies2015
- Author(s)
  Hasegawa, Y., Higashi, K., Yamamoto, K., Moribe, K.
- Journal Title
  
  Molecular Pharmaceutics
  
  Volume: 12 (5) Issue: 5 Pages: 1564-1572
- DOI
  10.1021/mp500872g
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K07885
[Journal Article] Effects of the PEG molecular weight of a PEG-lipid and cholesterol on PEG chain flexibility on liposome surfaces2015
- Author(s)
  Abe, A., Higashi, K., Watabe, K., Kobayashi, A., Limwikrant, W., Yamamoto, K., Moribe, K.
- Journal Title
  
  Colloids and Surfaces A: Physicochemical and Engineering Aspects
  
  Volume: 474 (5) Pages: 63-70
- DOI
  10.1016/j.colsurfa.2015.03.006
- NAID
  120007054171
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24790041
[Journal Article] Inhibition mechanism of hydroxypropyl methylcellulose acetate succinate on drug crystallization in gastrointestinal fluid and drug permeability from a supersaturated solution2014
- Author(s)
  Ueda, K., Higashi, K., Kataoka, M., Yamashita, S., Yamamoto, K., Moribe, K.
- Journal Title
  
  Eur. J. Pharm. Sci.
  
  Volume: 62 Pages: 293-300
- DOI
  10.1016/j.ejps.2014.06.007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-14J03968, KAKENHI-PROJECT-24590045
[Journal Article] Encapsulation of poorly water-soluble drugs into organic nanotubes for improving drug dissolution2014
- Author(s)
  Moribe, K., Makishima, T., Higashi, K, Liu, N., Limwikrant, W., Ding, W., Masuda, M., Shimizu, T., Yamamoto, K.
- Journal Title
  
  Int. J. Pharm.
  
  Volume: 469 (1) Issue: 1 Pages: 190-196
- DOI
  10.1016/j.ijpharm.2014.04.005
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25460032
[Journal Article] The effect of HPMCAS functional groups on drug crystallization from the supersaturated state and dissolution improvement2014
- Author(s)
  Ueda, K., Higashi, K., Yamamoto, K., Moribe, K
- Journal Title
  
  Int. J. Pharm.
  
  Volume: 464 (1-2) Issue: 1-2 Pages: 205-213
- DOI
  10.1016/j.ijpharm.2014.01.005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-14J03968, KAKENHI-PROJECT-24590045
[Journal Article] Structural determination of a novel polymorph of sulfathiazole-oxalic acid complex in powder form by solid-state NMR spectroscopy on the basis of crystallographic structure of another polymorph2014
- Author(s)
  Koike, R., Higashi, K., Liu, N., Limwikrant, W., Yamamoto, K., Moribe, K.
- Journal Title
  
  Cryst. Growth Des.
  
  Volume: 14 Issue: 9 Pages: 4510-4518
- DOI
  10.1021/cg5005903
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24790041
[Journal Article] Application of intermolecular spaces between polyethylene glycol/γ-cyclodextrin-polypseudorotaxanes as a host for various guest drugs2014
- Author(s)
  Higashi, K., Waraya, H., Lin, L. K., Namiki, S., Ogawa, M., Limwikrant, W., Yamamoto, K., Moribe, K.
- Journal Title
  
  Cryst. Growth Des.
  
  Volume: 14 (6) Issue: 6 Pages: 2773-2781
- DOI
  10.1021/cg401934v
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25460032
[Journal Article] Drug solubilization mechanism of alpha-glucosyl stevia by NMR spectroscopy2014
- Author(s)
  Zhang, J., Higashi, K., Ueda, K., Kadota, K., Tozuka, Y., Limwikrant, W., Yamamoto, K., Moribe, K.
- Journal Title
  
  Int. J. Pharm.
  
  Volume: 465 (1-2) Issue: 1-2 Pages: 255-261
- DOI
  10.1016/j.ijpharm.2014.01.035
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-14J03968, KAKENHI-PROJECT-24790041, KAKENHI-PROJECT-25504018
[Journal Article] Inhibitory effect of hydroxypropyl methylcellulose acetate succinate on drug recrystallization from a supersaturated solution assessed using nuclear magnetic resonance measurements2013
- Author(s)
  K. Ueda, K. Higashi, K. Yamamoto
- Journal Title
  
  Mol. Pharm.
  
  Volume: 10 Issue: 1 Pages: 3801-3811
- DOI
  10.1021/mp4005723
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590045, KAKENHI-PROJECT-24790041
[Journal Article] Structural evaluation of probucol nano particles in water by atomic force microscopy2012
- Author(s)
  K. Moribe, W. Limwikrant, K. Higashi, K. Yamamoto
- Journal Title
  
  Int J Pharm
  
  Volume: 427 Pages: 365-371
- Data Source
  KAKENHI-PROJECT-21590038
[Journal Article] Yellow coloration phenomena of incorporated indomethacin into folded sheet mesoporous materials2012
- Author(s)
  S. Tanabe, K. Higashi, M. Umino, W. Limwikrant, K. Yamamoto, K. Moribe
- Journal Title
  
  Int. J. Pharm
  
  Volume: 429 Pages: 38-45
- Data Source
  KAKENHI-PROJECT-23659017
[Journal Article] Structural evaluation of probucol nanoparticles in water by atomic force microscopy2012
- Author(s)
  K.Moribe, W.Limwikrant, K.Higashi, K.Yamamoto
- Journal Title
  
  Int J Pharm
  
  Volume: 427 Issue: 2 Pages: 365-371
- DOI
  10.1016/j.ijpharm.2012.02.020
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590038
[Journal Article] Yellow coloration phenomena of incorporated indomethacin into foldedsheet mesoporous materials2012
- Author(s)
  S. Tanabe, K. Higashi, M. Umino, W. Limwikrant, K. Yamamoto, K. Moribe
- Journal Title
  
  Int. J. Pharm
  
  Volume: 429 Pages: 38-45
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790032
[Journal Article] Molecular-level characterization ofprobucol nanocrystal in water by insitu solid-state NMR spectroscopy.2012
- Author(s)
  J. Zhang, K. Higashi, W. Limwikrant, K. Moribe, K. Yamamoto
- Journal Title
  
  Int. J. Pharm
  
  Volume: 423 Pages: 571-576
- Data Source
  KAKENHI-PROJECT-21590038
[Journal Article] Stabilization of a Supersaturated Solution of Mefenamic Acid from a Solid Dispersion with EUDRAGIT(R)EPO2012
- Author(s)
  Kojima, K. Higashi, T. Suzuki, K. Tomono, K. Moribe, K. Yamamoto
- Journal Title
  
  Pharm Res
- Data Source
  KAKENHI-PROJECT-21590038
[Journal Article] Molecular-level characterization of probucol nanocrystal in water by in situsolid-state NMR spectroscopy2012
- Author(s)
  J. Zhang. K. Higashi, M. Umino, W. Limwikrant, K. Yamamoto, K. Moribe
- Journal Title
  
  Int. J. Pharm
  
  Volume: 423 Pages: 571-576
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790032
[Journal Article] Transglycosylated Rutin-Specific Non-Surface-Active Nanostructure Affects Absorption Enhancement of Flurbiprofen2012
- Author(s)
  Yuichi Tozuka
- Journal Title
  
  European Journal of Pharmaceutics and Biopharmaceutics
  
  Volume: 82 Issue: 1 Pages: 120-126
- DOI
  10.1016/j.ejpb.2012.05.005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790041, KAKENHI-PROJECT-24590045
[Journal Article] Stabilization of a Supersaturated Solution of Mefenamic Acid from a Solid Dispersion with EUDRAGIT([○!R]) EPO2012
- Author(s)
  T.Kojima, K.Higashi, T.Suzuki, K.Tomono, K.Moribe, K. Yamamoto
- Journal Title
  
  Pharm Res
  
  Volume: (印刷中) Issue: 10 Pages: 2777-2791
- DOI
  10.1007/s11095-011-0655-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590038, KAKENHI-PROJECT-22590149, KAKENHI-PROJECT-24790041
[Journal Article] Molecular-level characterization of probucol nanocrystal in water by in situ solid-state NMR spectroscopy2012
- Author(s)
  J.Zhang, K.Higashi, W. Limwikrant, K.Moribe, K.Yamamoto
- Journal Title
  
  Int J Pharm
  
  Volume: 423 Issue: 2 Pages: 571-576
- DOI
  10.1016/j.ijpharm.2011.11.028
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590038, KAKENHI-PROJECT-21790032, KAKENHI-PROJECT-24790041
[Journal Article] Yellow coloration phenomena of incorporated indomethacin into folded sheet mesoporous materials2012
- Author(s)
  S.Tanabe
- Journal Title
  
  International Journal of Pharmaceutics
  
  Volume: (印刷中) Issue: 1-2 Pages: 38-45
- DOI
  10.1016/j.ijpharm.2012.03.011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790032, KAKENHI-PROJECT-23659017
[Journal Article] Mechanistic differences in permeation behavior of supersaturated and solubilized solutions of carbamazepine revealed by nuclear magnetic resonance measurements.2012
- Author(s)
  Ueda K, Higashi K, Limwikrant W, Sekine S, Horie T, Yamamoto K, Moribe K.
- Journal Title
  
  Mol. Pharm.
  
  Volume: 9 Issue: 11 Pages: 3023-3033
- DOI
  10.1021/mp300083e
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249003, KAKENHI-PROJECT-23659073, KAKENHI-PROJECT-23790172, KAKENHI-PROJECT-24590045
[Journal Article] Structural evaluation of crystalline ternary γ-cyclodextrin complex.2011
- Author(s)
  K.Higashi, S.Ideura, H.Waraya, K.Moribe, K.Yamamoto
- Journal Title
  
  J.Pharm.Sci.
  
  Volume: 100 Pages: 325-333
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590038
[Journal Article] Guest molecular size-dependent inclusion complexation of parabens with cholic acid by cogrinding2011
- Author(s)
  K.Moribe, M.Masaki, R.Kinoshita, J.Zhang, W.Limwikrant, K.Higashi, Y.Tozuka, T.Oguchi, K.Yamamoto
- Journal Title
  
  Int.J.Pharm
  
  Volume: 420 Issue: 2 Pages: 191-197
- DOI
  10.1016/j.ijpharm.2011.08.027
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590038
[Journal Article] NMR investigation of a novel excipient, α-glucosylhesperidin, as a suitable solubilizing agent for poorly water-soluble drugs2011
- Author(s)
  J. Zhang, Y. Tozuka, H. Uchiyama, K. Higashi, K. Moribe, H. Takeuchi, K. Yamamoto
- Journal Title
  
  J. Pharm.Sci
  
  Volume: 100 Pages: 4421-4431
- Data Source
  KAKENHI-PROJECT-21590038
[Journal Article] Guest molecular size-dependent inclusion complexation of parabens with cholic acid by cogrinding2011
- Author(s)
  K. Moribe, M. Masaki, R. Kinoshita, J. Zhang, W. Limwikrant, K. Higashi, Y. Tozuka, T. Oguchi, K. Yamamoto
- Journal Title
  
  Int. J. Pharm
  
  Volume: 420 Pages: 191-197
- Data Source
  KAKENHI-PROJECT-21590038
[Journal Article] NMR investigation of a novel excipient, α-glucosylhesperidin, as a suitable solubilizing agent for poorly water-soluble drugs2011
- Author(s)
  J.Zhang, Y.Tozuka, H.Uchiyama, K.Higashi, K.Moribe, H.Takeuchi, K.Yamamoto
- Journal Title
  
  J.Pharm.Sci
  
  Volume: 100 Issue: 10 Pages: 4421-4431
- DOI
  10.1002/jps.22606
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590038, KAKENHI-PROJECT-22790041
[Journal Article] Structural evaluation of crystalline ternaryγ-cyclodextrin complex2011
- Author(s)
  K. Higashi, S. Ideura, H. Waraya, K. Moribe, K. Yamamoto
- Journal Title
  
  J. Pharm.Sci
  
  Volume: 100 Pages: 325-333
- Data Source
  KAKENHI-PROJECT-21590038
[Journal Article] Ascorbyl dipalmitate/PEG-lipid nanoparticles as a novel carrier for hydrophobic drugs2010
- Author(s)
  K. Moribe, S. Maruyama, Y. Inoue, T. Suzuki, T. Fukami, K. Tomono, K. Higashi, Y. Tozuka, K. Yamamoto
- Journal Title
  
  Int. J. Pharm
  
  Volume: 387 Pages: 236-243
- Data Source
  KAKENHI-PROJECT-21590038
[Journal Article] Simultaneous dissolution of naproxen and flurbiprofen from a novel ternary gamma-cyclodextrin complex.2010
- Author(s)
  K.Higashi, S.Ideura, H.Waraya, W.Limwikrant, K.Moribe, K.Yamamoto
- Journal Title
  
  Chem.Pharm.Bull.
  
  Volume: 58 Pages: 769-772
- NAID
  130000255846
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590038
[Journal Article] Ascorbyl dipalmitate/PEG-lipid nanoparticles as a novel carrier for hydrophobic drugs2010
- Author(s)
  K.Moribe, S.Maruyama, Y.Inoue, T.Suzuki, T.Fukami, K.Tomono, K.Higashi, Y.Tozuka, K.Yamamoto
- Journal Title
  
  Int.J.Pharm. 387
  
  Pages: 236-243
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590038
[Journal Article] Effect of particle size on skin permeation and retention of piroxicam in aqueous suspension2010
- Author(s)
  K. Moribe, M. Shibata, T. Furuishi, K. Higashi, K. Tomono, K. Yamamoto
- Journal Title
  
  Chem. Pharm. Bull
  
  Volume: 58 Pages: 1096-1099
- NAID
  130000299822
- Data Source
  KAKENHI-PROJECT-21590038
[Journal Article] Effect of particle size on skin permeation and retention of piroxicam in aqueous suspension2010
- Author(s)
  K.Moribe, M.Shihata, T.Furuishi, K.Higashi, K.Tomono, K.Yamamoto
- Journal Title
  
  Chem.Pharm.Bull.
  
  Volume: 58 Pages: 1096-1099
- NAID
  130000299822
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590038
[Journal Article] alicylicacid/γ-cyclodextrin2:1 and 4:1 complex formation by sealed-heating method2010
- Author(s)
  K. Higashi, Y. Tozuka, K. Moribe, K. Yamamoto
- Journal Title
  
  J. Pharm. Sci
  
  Volume: 99 Pages: 4192-4200
- Data Source
  KAKENHI-PROJECT-21590038
[Journal Article] Simultaneous dissolution of naproxen and flurbiprofen from anovel ternary gamma-cyclodextrin complex2010
- Author(s)
  K. Higashi, S. Ideura, H. Waraya, W. Limwikrant, K. Moribe, K. Yamamoto
- Journal Title
  
  Chem. Pharm. Bull
  
  Volume: 58 Pages: 769-772
- Data Source
  KAKENHI-PROJECT-21590038
[Journal Article] Prednisolone multicomponent nanoparticle preparation by aerosol solvent extraction system.2009
- Author(s)
  K.Moribe, M.Fukino, Y.Tozuka, K.Higashi, K.Yamamoto
- Journal Title
  
  Int.J.Pharm. 380
  
  Pages: 201-205
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590038
[Journal Article] Characterization of ofloxacin-oxalic acid complex byPXRD, NMR, and THz spectroscopy2009
- Author(s)
  W. Limwikrant, K. Higashi, K. Yamamoto, K. Moribe
- Journal Title
  
  Int. J. Pharm
  
  Volume: 382 Pages: 50-55
- Data Source
  KAKENHI-PROJECT-21590038
[Journal Article] Characterization of ofloxacin-oxalic acid complex by PXRD, NMR, and THz spectroscopy2009
- Author(s)
  W.Limwikrant, K.Higashi, K.Yamamoto, K.Moribe
- Journal Title
  
  Int.J.Pharm. 382
  
  Pages: 50-55
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590038
[Journal Article] Nanoparticle formation from probucol/PVP/sodium alkyl sulfate co-ground mixture2009
- Author(s)
  C.Wanawongthai, A.Pongpeerapat, K.Higashi, Y.Tozuka, K.Moribe, K.Yamamoto
- Journal Title
  
  Int.J.Pharm. 376
  
  Pages: 169-175
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590038
[Journal Article] Prednisolone multicomponent nanoparticle preparation by aerosol solvent extraction system2009
- Author(s)
  K. Moribe, M. Fukino, Y. Tozuka, K. Higashi, K. Yamamoto
- Journal Title
  
  Int. J. Pharm
  
  Volume: 380 Pages: 201-205
- Data Source
  KAKENHI-PROJECT-21590038
[Journal Article] Nanoparticle formation from probucol/PVP/sodium alkyl sulfate co-ground mixture2009
- Author(s)
  C. Wanawongthai, A. Pongpeerapat, K. Higashi, Y. Tozuka, K. Moribe, K. Yamamoto
- Journal Title
  
  Int. J.Pharm
  
  Volume: 376 Pages: 169-75
- Data Source
  KAKENHI-PROJECT-21590038
[Presentation] 固体NMR緩和時間測定を用いた第二薬物混合によるfelodipine結晶化抑制メカニズムの解明2024
- Author(s)
  菅原日向, 植田圭祐, 東顕二郎, 森部久仁一
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-22K06545
[Presentation] リポソームへのdoxorubicin封入率にPEG修飾が及ぼす影響の評価2024
- Author(s)
  藤本泰輝, 植田圭祐, 東顕二郎, 森部久仁一
- Organizer
  PF研究会「物質・生命研究における小角散乱法の展開：現状と展望のための討論会」
- Data Source
  KAKENHI-PROJECT-22K06545
[Presentation] Ritonavirの非晶質溶解度に第2薬物が及ぼす影響の熱力学的解析2024
- Author(s)
  植田圭祐, 金子舜, 東顕二郎, 森部久仁一
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-22K06545
[Presentation] 脂質/γ-シクロデキストリン温度応答性ナノ粒子への薬物封入2024
- Author(s)
  関優太, 植田圭祐, 東顕二郎, 森部久仁一
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-22K06545
[Presentation] PEG修飾によるdoxorubicin封入リポソームの形態変化メカニズム評価2024
- Author(s)
  藤本泰輝, 植田圭祐, 東顕二郎, 森部久仁一
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-22K06545
[Presentation] 溶液1H NMR測定によるリポソーム界面へ修飾されたPEGの局在評価2024
- Author(s)
  東顕二郎, 仲村美咲, 植田圭祐, 森部久仁一
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-22K06545
[Presentation] 原子間力顕微鏡を用いたイリノテカン封入リポソームの力学的特性評価2024
- Author(s)
  喜田浩平, 植田圭祐, 東顕二郎, 森部久仁一
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-22K06545
[Presentation] 脂質ナノ粒子のpH依存的な構造変化にイオン化脂質が及ぼす影響2024
- Author(s)
  酒川優泉, 植田圭祐, 東顕二郎, 森部久仁一
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-22K06545
[Presentation] 分子運動性に基づく非晶質estradiolの物理的安定性予測2023
- Author(s)
  原脩祐、植田圭祐、東顕二郎、森部久仁一
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-22K06545
[Presentation] 溶液?H NMRによるナノエマルション中の薬物封入状態の定量的評価2023
- Author(s)
  富田紗枝子, 砂塚裕志, 植田圭祐, 東顕二郎, 森部久仁一
- Organizer
  第67回日本薬学会関東支部会
- Data Source
  KAKENHI-PROJECT-22K06545
[Presentation] Crystallization of amorphous drug nanoparticle in water2023
- Author(s)
  Higashi K
- Organizer
  International Conference on Science and Technology of Pharmaceutical Glass
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06509
[Presentation] NMR緩和時間測定によるritonavir結晶多形・非晶質の局所構造評価2023
- Author(s)
  鈴木雅人, 植田圭祐, 東顕二郎, 森部久仁一
- Organizer
  第67回日本薬学会関東支部会
- Data Source
  KAKENHI-PROJECT-22K06545
[Presentation] NMRを用いた脂質ナノ粒子への核酸封入機構の解明2023
- Author(s)
  植田圭祐, 西村公樹, 武田　純平, 新井　勇太, 山本　克彦, 池田幸弘, 東顕二郎, 森部久仁一
- Organizer
  第39回日本DDS学会
- Data Source
  KAKENHI-PROJECT-22K06545
[Presentation] Correlation between drug molecular state in cyclodextrin-polypseudorotaxane complexes and its sublimation rate2023
- Author(s)
  Kundu, S., Ueda, K., Higashi, K., Moribe, K.
- Organizer
  International Conference on Science and Technology of Pharmaceutical Glass
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K06545
[Presentation] Acetaminophen封入poloxamer 407ミセルの結晶構造とゲル物性の関連性評価2023
- Author(s)
  佐久間文絵, 植田圭祐, 東顕二郎, 庵原大輔, 平山文敏, 森部久仁一
- Organizer
  日本薬剤学会　第48回製剤・創剤セミナー
- Data Source
  KAKENHI-PROJECT-22K06545
[Presentation] In situ X線散乱測定を用いた冷却過程におけるドキソルビシン封入リポソームの形態及び分子状態評価2023
- Author(s)
  徳本大成、植田圭祐、東顕二郎、小坂井賢太、田口宗孝、大坂恵一、岩尾康範、森部久仁一
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-22K06545
[Presentation] Acetaminophen封入がpoloxamer 407のミセル及びゲル特性に及ぼす影響2023
- Author(s)
  佐久間文絵, 植田圭祐, 東顕二郎, 庵原大輔, 平山文敏, 森部久仁一
- Organizer
  新製剤技術とエンジニアリングを考える会　第20回技術講演会
- Data Source
  KAKENHI-PROJECT-22K06545
[Presentation] Poloxamer 407のミセル及びゲル特性にacetaminophen封入が及ぼす影響2023
- Author(s)
  佐久間文絵, 植田圭祐, 東顕二郎, 庵原大輔, 平山文敏, 森部久仁一
- Organizer
  日本薬剤学会第38年会
- Data Source
  KAKENHI-PROJECT-22K06545
[Presentation] 製剤を分子・ナノレベルで顕わにする2023
- Author(s)
  東　顕二郎
- Organizer
  崇城大学DDS研究所特別講演会
- Invited
- Data Source
  KAKENHI-PROJECT-21K06509
[Presentation] 分子動力学計算を用いた Eudragit? Eによる薬物可溶化機構の解明2023
- Author(s)
  齊藤智輝, 植田圭祐, 東顕二郎, 奥脇弘次, 古石誉之, 福澤薫, 米持悦生, 森部久仁一
- Organizer
  第67回日本薬学会関東支部会
- Data Source
  KAKENHI-PROJECT-22K06545
[Presentation] Effect of formulation component on supersaturation and phase separation of poorly water-soluble drugs2023
- Author(s)
  Kunikazu Moribe、Keisuke Ueda、Kenjirou Higashi
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-22K06545
[Presentation] Formation and stabilization mechanism of colloidal dispersions of drug nanoparticles obtained from ternary solid dispersions2023
- Author(s)
  Higashi, K., Ueda, K., Moribe, K.,
- Organizer
  Asisan Federation for Pharmaceutical Sciences 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06509
[Presentation] PEG修飾がdoxorubicin封入リポソームの薬物封入効率及び形態変化に及ぼす影響2023
- Author(s)
  藤本泰輝, 植田圭祐, 東顕二郎, 森部久仁一
- Organizer
  第67回日本薬学会関東支部会
- Data Source
  KAKENHI-PROJECT-22K06545
[Presentation] 結晶学的理論に基づいたナノ医薬品製剤の物性評価2023
- Author(s)
  東　顕二郎
- Organizer
  第3回令和の薬剤学を考える懇談会
- Invited
- Data Source
  KAKENHI-PROJECT-21K06509
[Presentation] Elucidation of the mechanism of morphological change in DOX-loaded liposome by cryo-TEM and X-ray scattering2023
- Author(s)
  Tokumoto Taisei、Ueda Keisuke、Higashi Kenjirou、Moribe Kunikazu
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-22K06545
[Presentation] Formation and stabilization mechanism of colloidal dispersions of drug nanoparticles obtained from ternary solid dispersions2023
- Author(s)
  Higashi, K., Ueda, K., Moribe, K.,
- Organizer
  Asisan Federation for Pharmaceutical Sciences 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K06545
[Presentation] 溶液1H NMR測定を用いたリポソーム界面へ修飾したPEGの分子状態評価2023
- Author(s)
  仲村美咲, 植田圭祐, 東顕二郎, 森部久仁一
- Organizer
  日本薬剤学会第38年会
- Data Source
  KAKENHI-PROJECT-22K06545
[Presentation] 異なる薬物の共存がritonavirの液-液相分離及び非晶質溶解度に与える影響の評価2023
- Author(s)
  金子舜, 植田圭祐, 東顕二郎, 森部久仁一
- Organizer
  第40回製剤と粒子設計シンポジウム
- Data Source
  KAKENHI-PROJECT-22K06545
[Presentation] Effect of PEG modification on drug encapsulation efficiency and morphology of doxorubicin-loaded liposome2023
- Author(s)
  Fujimoto, K., Ueda, K., Higashi, K., Moribe, K.
- Organizer
  Asisan Federation for Pharmaceutical Sciences 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K06545
[Presentation] 溶液NMRによる薬物過飽和溶解領域の定量的解析2023
- Author(s)
  植田圭祐, 東顕二郎, 森部久仁一
- Organizer
  第40回製剤と粒子設計シンポジウム
- Data Source
  KAKENHI-PROJECT-22K06545
[Presentation] 液-液相分離により形成されるcilnidipine濃縮相物性が腸管吸収性に及ぼす影響2022
- Author(s)
  竹本士竜, 植田圭祐, 東顕二郎, 森部久仁一
- Organizer
  日本薬剤学会第37年会
- Data Source
  KAKENHI-PROJECT-22K06545
[Presentation] 調製時に用いる溶媒が非晶質cyclosporine Aの分子状態に及ぼす影響2022
- Author(s)
  内田みず穂, 植田圭祐, 東顕二郎, 森部久仁一
- Organizer
  日本薬剤学会　第47回製剤・創剤セミナー
- Data Source
  KAKENHI-PROJECT-22K06545
[Presentation] Characterization of drug-rich phase formed by liquid-liquid phase separation and its significance on intestinal absorption of drug.2022
- Author(s)
  Takemoto, S., Ueda, K., Higashi, K., Moribe, K.
- Organizer
  4th?International Symposium on BA/BE of Oral Drug Products, 2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K06545
[Presentation] Acetaminophen封入がpoloxamer 407のゲル形成に及ぼす影響の評価2022
- Author(s)
  佐久間文絵, 植田圭祐, 東顕二郎, 森部久仁一
- Organizer
  第66回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-22K06545
[Presentation] 薬物/シクロデキストリン‐ポリシュードロタキサン複合体の分子運動性が薬物昇華速度に与える影響2022
- Author(s)
  Sudeshna Kundu, 植田圭祐, 東顕二郎, 森部久仁一
- Organizer
  第38回シクロデキストリンシンポジウム
- Data Source
  KAKENHI-PROJECT-22K06545
[Presentation] シクロデキストリン誘導体によるchlorthalidone結晶化抑制作用の評価2022
- Author(s)
  劉夢遥，植田圭祐, 東顕二郎, 森部久仁一
- Organizer
  日本薬剤学会第37年会
- Data Source
  KAKENHI-PROJECT-22K06545
[Presentation] 調製時に用いる溶媒が非晶質cyclosporine Aの分子状態に及ぼす影響2022
- Author(s)
  内田みず穂, 植田圭祐, 東顕二郎, 森部久仁一
- Organizer
  日本薬剤学会　第47回製剤・創剤セミナー
- Data Source
  KAKENHI-PROJECT-21K06509
[Presentation] エマルション中における過飽和溶解fenofibrateの相分離挙動評価2022
- Author(s)
  江寺理紗, 植田圭祐, 東顕二郎, 森部久仁一
- Organizer
  日本薬剤学会第37年会
- Data Source
  KAKENHI-PROJECT-22K06545
[Presentation] エマルション製剤における過飽和溶解fenofibrateの相分離挙動評価2022
- Author(s)
  江寺理紗, 植田圭祐, 東顕二郎, 森部久仁一
- Organizer
  日本薬剤学会　第48回製剤・創剤セミナー
- Data Source
  KAKENHI-PROJECT-22K06545
[Presentation] 溶液1H NMR測定によるリポソーム界面へ修飾したPEG鎖の評価2022
- Author(s)
  仲村美咲, 植田圭祐, 東顕二郎, 森部久仁一
- Organizer
  第66回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-22K06545
[Presentation] Cyclosporine A非晶質の分子状態に調製条件が及ぼす影響2022
- Author(s)
  内田みず穂, 植田圭祐, 東顕二郎, 森部久仁一
- Organizer
  日本薬剤学会第37年会
- Data Source
  KAKENHI-PROJECT-22K06545
[Presentation] Eudragit E POの構造がfelodipineの結晶化抑制作用に及ぼす影響2022
- Author(s)
  向出彩華, 植田圭祐, 東顕二郎, 森部久仁一
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-20K06985
[Presentation] Cryo-TEM及びSAXSを用いたドキソルビシン封入リポソームの形態変化メカニズム評価2022
- Author(s)
  徳本大成, 植田圭祐, 東顕二郎, 森部久仁一
- Organizer
  日本薬剤学会第37年会
- Data Source
  KAKENHI-PROJECT-22K06545
[Presentation] 過飽和溶液中にて形成されるcilnidipine濃縮相の粒子特性が腸管吸収性に及ぼす影響2022
- Author(s)
  竹本士竜, 植田圭祐, 東顕二郎, 森部久仁一
- Organizer
  第39回製剤と粒子設計シンポジウム
- Data Source
  KAKENHI-PROJECT-22K06545
[Presentation] シクロデキストリン誘導体によるクロロタリドン結晶化抑制作用の評価2022
- Author(s)
  劉夢遥，植田圭祐, 東顕二郎, 森部久仁一
- Organizer
  第38回シクロデキストリンシンポジウム
- Data Source
  KAKENHI-PROJECT-22K06545
[Presentation] 高温固体1H NMR分光法による薬物/polymer間相互作用の評価2022
- Author(s)
  金子舜, 植田圭祐, 東顕二郎, 森部久仁一
- Organizer
  第66回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-22K06545
[Presentation] In situ X線散乱測定を用いたドキソルビシン封入リポソーム形態変化機構の解明2022
- Author(s)
  徳本大成, 植田圭祐, 東顕二郎, 森部久仁一
- Organizer
  第39回製剤と粒子設計シンポジウム
- Data Source
  KAKENHI-PROJECT-22K06545
[Presentation] Cyclosporine A非晶質の分子状態に調製条件が及ぼす影響2022
- Author(s)
  内田みず穂, 植田圭祐, 東顕二郎, 森部久仁一
- Organizer
  日本薬剤学会第37年会
- Data Source
  KAKENHI-PROJECT-21K06509
[Presentation] Impact of molecular state of drug/cyclodextrin-polypseudorotaxane complexes on drug sublimation rate2022
- Author(s)
  Sudeshna Kundu, 植田圭祐, 東顕二郎, 森部久仁一
- Organizer
  日本薬剤学会第37年会
- Data Source
  KAKENHI-PROJECT-22K06545
[Presentation] 過飽和溶液中にて形成されるcilnidipine濃縮相物性が腸管吸収性に及ぼす影響2022
- Author(s)
  竹本士竜, 植田圭祐, 東顕二郎, 森部久仁一
- Organizer
  新製剤技術とエンジニアリングを考える会　第19回技術講演会
- Data Source
  KAKENHI-PROJECT-22K06545
[Presentation] Eudragit E POの液中構造が薬物の結晶成長抑制作用に及ぼす影響2021
- Author(s)
  向出彩華，植田圭祐, 東顕二郎, 森部久仁一
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-20K06985
[Presentation] 固体NMRの原薬・製剤評価への応用2021
- Author(s)
  東　顕二郎
- Organizer
  情報機構WEBセミナー
- Invited
- Data Source
  KAKENHI-PROJECT-18K06592
[Presentation] Eudragit Eの液中構造がフェロジピンの結晶成長抑制作用に及ぼす影響2021
- Author(s)
  向出彩華, 植田圭祐, 東顕二郎, 森部久仁一
- Organizer
  日本薬剤学会第36年会
- Data Source
  KAKENHI-PROJECT-20K06985
[Presentation] Eudragit E POの液中構造がフェロジピンの結晶化抑制作用に及ぼす影響2021
- Author(s)
  向出彩華, 植田圭祐, 東顕二郎, 森部久仁一
- Organizer
  第38回製剤と粒子設計シンポジウム
- Data Source
  KAKENHI-PROJECT-20K06985
[Presentation] 薬物の溶解性・吸収性を改善する医薬品製剤の評価2021
- Author(s)
  東顕二郎
- Organizer
  第69回固体NMR・材料フォーラム
- Invited
- Data Source
  KAKENHI-PROJECT-21K06509
[Presentation] 固体NMRによる薬物溶解性を改善する特殊製剤の評価2020
- Author(s)
  東　顕二郎
- Organizer
  第64回日本薬学会関東支部大会
- Invited
- Data Source
  KAKENHI-PROJECT-18K06592
[Presentation] 溶液NMR測定を用いたPVPによる薬物結晶核生成抑制メカニズムの評価2020
- Author(s)
  山本　根生、植田　圭祐、東　顕二郎、森部　久仁一
- Organizer
  日本薬剤学会第35年会
- Data Source
  KAKENHI-PROJECT-20K06985
[Presentation] Eudragit E POの液中構造が薬物の結晶化抑制作用に及ぼす影響2020
- Author(s)
  向出彩華, 植田圭祐, 東顕二郎, 森部久仁一
- Organizer
  第64回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-20K06985
[Presentation] 調製条件がglibenclamide非晶質ナノ粒子の物理的安定性に及ぼす影響2020
- Author(s)
  東顕二郎、森川　千佳子、植田圭祐、森部久仁一
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-18K06592
[Presentation] 医薬品ナノ粒子製剤の設計とその構造解析2019
- Author(s)
  東　顕二郎
- Organizer
  第25回創剤フォーラム若手研究会
- Invited
- Data Source
  KAKENHI-PROJECT-18K06592
[Presentation] 固体NMRによる薬物溶解性改善製剤の分子状態評価2019
- Author(s)
  東　顕二郎
- Organizer
  製剤機械技術学会第29回大会
- Invited
- Data Source
  KAKENHI-PROJECT-18K06592
[Presentation] Preparation of amorphous nanoparticles for drugs with mid-molecular weight by wet bead milling and its characterization2019
- Author(s)
  Chen, Z., Ueda, K., Higashi, K., Moribe, K.
- Organizer
  The 3rd Workshop for Japan-Korea Young Scientists on Pharmaceutics
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06592
[Presentation] NMRによる難水溶性薬物の溶解性を改善する特殊製剤の構造評価2019
- Author(s)
  東　顕二郎
- Organizer
  高分子学会19-2　NMR研究会
- Invited
- Data Source
  KAKENHI-PROJECT-18K06592
[Presentation] Preformulation study to enhance the drug solubility based on solid state NMR methodology2019
- Author(s)
  Higashi, K.
- Organizer
  2019 International Conference of the KSPST
- Invited
- Data Source
  KAKENHI-PROJECT-18K06592
[Presentation] Effect of molecular state of ternary solid dispersion on the physical property and stability of amorphous drug nanoparticles formed by aqueous dispersion2019
- Author(s)
  Zhao, Z., Katai, H., Ueda, K., Higashi, K., Moribe, K.
- Organizer
  The 1st Pharmaceutial Sciences Asia Conference 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06592
[Presentation] Effect of surfactant in ternary solid dispersion on the formation of amorphous probucol nanoparticles by aqueous dispersion2019
- Author(s)
  Zhao, Z., Ueda, K., Higashi, K., Moribe, K.
- Organizer
  The 3rd Workshop for Japan-Korea Young Scientists on Pharmaceutics
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06592
[Presentation] Molecular-level understanding of stabilization mechanism of amorphous cyclosporin A nanosuspension prepared by wet bead milling with Pluronic F1272018
- Author(s)
  Ziqiao Chen, Keisuke Ueda, Kenjirou Higashi, Kunikazu Moribe
- Organizer
  第35回製剤と粒子設計シンポジウム
- Data Source
  KAKENHI-PROJECT-18K06592
[Presentation] 難溶性薬物Nobiletinの封入脂質ナノ粒子製剤の調製と経口製剤としての有用性の評価2018
- Author(s)
  松尾聖羅, 岩尾康範, 東顕二郎, 森部久仁一, 金子雪子, 木村晋一郎, 近藤啓
- Organizer
  製剤機械技術学会第28回大会 (大阪)
- Data Source
  KAKENHI-PROJECT-17K08455
[Presentation] Effect of preparation method of ternary solid dispersion on the evolution of amorphous probucol nanoparticles formed after aqueous dispersion2018
- Author(s)
  Zhijing Zhao, Hiroaki Katai, Keisuke Ueda, Kenjirou Higashi, Kunikazu Moribe
- Organizer
  製剤機械技術学会第28回大会
- Data Source
  KAKENHI-PROJECT-18K06592
[Presentation] コアシェル構造を有するオレイン酸コレステリル/g-シクロデキストリンナノ粒子の調製2018
- Author(s)
  石本有沙, 植田圭祐, 笹子浩史, 東顕二郎, 神山和夫, 森部久仁一
- Organizer
  第３５回シクロデキストリンシンポジウム
- Data Source
  KAKENHI-PROJECT-18K06592
[Presentation] Oral formulation development of lipid nanoparticles encapsulated nobiletin, a poorly water-soluble compound2018
- Author(s)
  Seira Matsuo, Kenjirou Higashi, Kunikazu Moribe, Yukiko Kaneko, Shin-ichiro Kimura, Shigeru Itai, Yasunori Iwao, Hiromu Kondo
- Organizer
  6th International Conference on Pharmaceuticals, Nutraceuticals and Cosmetic Science 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08455
[Presentation] Preparation of cholesteryl oleate/g-cyclodextrin nanoparticles by solvent diffusion method2018
- Author(s)
  Ishimoto, A., Ueda, K., Higashi, K., Sasako, H., Koyama, K., Moribe, K.
- Organizer
  The 19th International Cyclodextrin Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06592
[Presentation] 医薬品製剤開発におけるNMRの応用：非晶質・ナノ製剤の評価を中心として2018
- Author(s)
  東　顕二郎
- Organizer
  JEOL RESONANCE NMR ユーザーズミーティング
- Invited
- Data Source
  KAKENHI-PROJECT-18K06592
[Presentation] Eudragit Eの液中構造が薬物可溶化能に及ぼす影響2018
- Author(s)
  岡本　裕太、植田　圭祐、東　顕二郎、森部　久仁一
- Organizer
  日本薬剤学会　製剤創剤セミナー
- Data Source
  KAKENHI-PROJECT-16K08190
[Presentation] Formation mechanism of drug nanoparticles obtained by aqueous dispersion of amorphous solid dispersion.2018
- Author(s)
  Higashi, K.
- Organizer
  The 2nd Workshop for Korea-Japan Young Scientists on Pharmaceutics
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06592
[Presentation] ナノ医薬品開発における電子顕微鏡の応用2017
- Author(s)
  東　顕二郎
- Organizer
  第6回大学連携研究設備ネットワーク研究成果報告会
- Invited
- Data Source
  KAKENHI-PROJECT-15K07885
[Presentation] Application of AFM for structural and morphological evaluation of drug-incorporated nanoparticles2017
- Author(s)
  Moribe, K., Egami, K., Takahashi, N., Ueda K., Higashi, K.
- Organizer
  Gordon Research Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08190
[Presentation] AFMを用いた水溶液中におけるEudragit® Eのナノ構造体評価2017
- Author(s)
  岡本裕太, 植田圭祐, 東顕二郎, 森部久仁一
- Organizer
  第61回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-16K08190
[Presentation] Glibenclamide非晶質ナノ粒子の構造評価：HPMC添加方法の影響2017
- Author(s)
  東　顕二郎,　與那城　葉月、植田　圭祐, 森部　久仁一、伊藤　努武、桝飛雄真、伊藤雅隆、野口修治
- Organizer
  第34回製剤と粒子設計シンポジウム計シンポジウム
- Data Source
  KAKENHI-PROJECT-15K07885
[Presentation] Cryo-TEM及びAFMによる脂質ナノ粒子の構造解析2017
- Author(s)
  松尾聖羅, 岩尾康範, 東顕二郎，森部久仁一, 木村晋一郎, 板井茂
- Organizer
  第42年会製剤・創剤セミナー (淡路島)
- Data Source
  KAKENHI-PROJECT-17K08455
[Presentation] 製剤開発における固体NMRの活用：基礎から応用まで2017
- Author(s)
  東　顕二郎
- Organizer
  日本薬学会東海支部　特別講演会
- Place of Presentation
  愛知
- Invited
- Data Source
  KAKENHI-PROJECT-15K07885
[Presentation] 分子レベルからデザイン！超分子構造体を基盤とした固体医薬品製剤の開発2017
- Author(s)
  東　顕二郎、植田　圭祐、森部　久仁一
- Organizer
  日本薬学会第138年会
- Invited
- Data Source
  KAKENHI-PROJECT-15K07885
[Presentation] Characterization of glibenclamide amorphous nanoparticles prepared by antisolvent method: Effect of hypromellose addition method2017
- Author(s)
  Higashi, K., Yonashiro, H., Ueda K., Itoh, T., Itoh, Masataka, Masu, H., Noguchi, S., Moribe, K.
- Organizer
  Asian federation pharmaceutical sciences 2017
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07885
[Presentation] Cryo-TEM及びAFMによる脂質ナノ粒子の構造解析2017
- Author(s)
  松尾聖羅, 岩尾康範, 東顕二郎，森部久仁一, 木村晋一郎, 板井茂
- Organizer
  第34回製剤と粒子設計シンポジウム (小倉)
- Data Source
  KAKENHI-PROJECT-17K08455
[Presentation] Characterization of amorphous cyclosporin A nanosuspension prepared by wet bead milling with poloxamer 4072017
- Author(s)
  Ziqiao CHEN, Keisuke UEDA, Kenjirou HIGASHI, Kunikazu MORIBE
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-15K07885
[Presentation] 分光法及び顕微鏡法を用いた薬物ナノ懸濁液の構造・分子状態の直接評価2017
- Author(s)
  東顕二郎, 植田圭祐, 森部久仁一
- Organizer
  日本薬学会第137年会
- Place of Presentation
  宮城
- Year and Date
  2017-03-25
- Invited
- Data Source
  KAKENHI-PROJECT-15K07885
[Presentation] 初期の薬物結晶形が湿式粉砕したナノ粒子の物性に及ぼす影響2016
- Author(s)
  森部久仁一, 黒岩洋佑, 植田圭祐, 東顕二郎, 山本恵司
- Organizer
  日本薬学会第136年会
- Place of Presentation
  横浜
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-15K07885
[Presentation] NMR法を用いた医薬品ナノ懸濁液の構造解明2016
- Author(s)
  東　顕二郎
- Organizer
  粉体工学会2016年度第１回粉体操作に伴う諸現象に関する勉強会
- Place of Presentation
  愛知
- Year and Date
  2016-07-28
- Invited
- Data Source
  KAKENHI-PROJECT-15K07885
[Presentation] 医薬品開発に用いられる製剤化技術の現状と展望2016
- Author(s)
  東　顕二郎
- Organizer
  エネルギー環境学域・JAXA宇宙環境利用WG合同講演会
- Place of Presentation
  茨城
- Invited
- Data Source
  KAKENHI-PROJECT-15K07885
[Presentation] AFM observation of morphological changes of doxorubicin-loaded liposomes2016
- Author(s)
  東顕二郎, 高橋　尚樹, 植田圭祐, 山本恵司, 森部久仁一
- Organizer
  第59回顕微鏡学会シンポジウム
- Place of Presentation
  東京
- Year and Date
  2016-11-18
- Data Source
  KAKENHI-PROJECT-16K08190
[Presentation] AFM及びcryo-TEMを用いたドキソルビシン封入リポソームの形態評価2016
- Author(s)
  森部久仁一、高橋尚希、植田圭祐、東顕二郎、山本恵司
- Organizer
  第32回日本DDS学会学術集会
- Place of Presentation
  静岡
- Year and Date
  2016-06-30
- Data Source
  KAKENHI-PROJECT-16K08190
[Presentation] Characterization of the mechanism of drug dissolution enhancement by saccharin addition from phenytoin/Eudragit E PO solid dispersion2016
- Author(s)
  Higashi, K., Ueda, K., Kanaya, H., Yamamoto, K., Moribe, K.
- Organizer
  58th Annual International Industrial Pharmaceutical Research and Development Conference
- Place of Presentation
  Madison,USA
- Year and Date
  2016-06-06
- Invited
- Data Source
  KAKENHI-PROJECT-15K07885
[Presentation] 3 成分 γ-シクロデキストリン複合体の溶解特性に及ぼすゲスト薬物の影響2016
- Author(s)
  劉楠, 植田圭祐, 東顕二郎, 山本恵司, 森部久仁一
- Organizer
  日本薬学会第136年会
- Place of Presentation
  横浜
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-25460032
[Presentation] 固体 NMR法による難水溶性薬物の溶解性を改善する特殊製剤の評価事例2015
- Author(s)
  東　顕二郎
- Organizer
  前臨床開発フォーカスグループ第1回合宿討論会
- Place of Presentation
  逗子
- Year and Date
  2015-12-10
- Data Source
  KAKENHI-PROJECT-15K07885
[Presentation] Indomethacinナノ懸濁液中における薬物結晶形の直接評価2015
- Author(s)
  黒岩洋佑, 植田圭祐, 東顕二郎, 山本恵司, 森部久仁一
- Organizer
  第32回製剤と粒子設計シンポジウム
- Place of Presentation
  豊橋
- Year and Date
  2015-10-22
- Data Source
  KAKENHI-PROJECT-15K07885
[Presentation] NMRによる特殊製剤の物性評価2015
- Author(s)
  東　顕二郎
- Organizer
  日本薬剤学会　経口吸収フォーカスグループ第５回合宿討論会
- Place of Presentation
  滋賀
- Year and Date
  2015-10-10
- Invited
- Data Source
  KAKENHI-PROJECT-15K07885
[Presentation] Aggregation and crystallization behavior of probucol from the ternary spray-dried sample solution evaluated by AFM2015
- Author(s)
  Moribe, K., Egami, K., Higashi, K., Ueda, K., Yamamoto, K.
- Organizer
  2015AAPS Annual Meeting and Exposition
- Place of Presentation
  Oralnd　USA
- Year and Date
  2015-10-25
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07885
[Presentation] チューブ状及びロッド状構造を形成する ASC-DP ナノ粒子の物性評価2015
- Author(s)
  東顕二郎, 重久友紀, 山本恵司, 森部久仁一
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-26
- Data Source
  KAKENHI-PROJECT-25460032
[Presentation] 懸濁ナノ粒子中のindomethacin結晶形の直接評価2015
- Author(s)
  黒岩洋佑, 東顕二郎, 山本恵司, 森部久仁一
- Organizer
  日本薬剤学会第30年会
- Place of Presentation
  長崎
- Year and Date
  2015-05-21
- Data Source
  KAKENHI-PROJECT-15K07885
[Presentation] Control of drug dissolution rate by crystalline ternary g-cyclodextrin complex formation2015
- Author(s)
  Liu, N., Higashi, K., Yamamoto, K., Moribe, K.
- Organizer
  Joint Conference of 8th Asian Cyclodextrin Conference and 32nd Cyclodextrin Symposium
- Place of Presentation
  熊本
- Year and Date
  2015-05-14
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460032
[Presentation] Solid state NMR study of three polymorphs of SA/(PEG/g-CD-PPRX) complex2015
- Author(s)
  Higashi, K., Takamizawa, M., Katai, H., Yamamoto, K., Moribe, K.
- Organizer
  Joint Conference of 8th Asian Cyclodextrin Conference and 32nd Cyclodextrin Symposium
- Place of Presentation
  熊本
- Year and Date
  2015-05-14
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460032
[Presentation] 混合粉砕及び加熱処理によるPEG/a-CD-PPRXへの薬物封入2015
- Author(s)
  小川茉里奈, 東顕二郎, 山本恵司, 森部久仁一
- Organizer
  日本薬剤学会第30年会
- Place of Presentation
  長崎
- Year and Date
  2015-05-21
- Data Source
  KAKENHI-PROJECT-25460032
[Presentation] Piroxicam/poloxamerナノ微粒子懸濁液の分子レベルの物性評価2014
- Author(s)
  長谷川友紀, 東顕二郎, 森部久仁一, 山本恵司
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-24790041
[Presentation] 3種類のサリチル酸/(PEG/g-CD-PPRX)複合体多形中におけるサリチル酸の溶解性及び分子状態評価2014
- Author(s)
  高見澤誠, 東顕二郎, 山本恵司, 森部久仁一
- Organizer
  第31回シクロデキストリンシンポジウム
- Place of Presentation
  島根
- Year and Date
  2014-09-11
- Data Source
  KAKENHI-PROJECT-25460032
[Presentation] 3種類のサリチル酸-擬ロタキサン複合体多形からの薬物溶出性評価2014
- Author(s)
  高見澤誠, 東顕二郎, 森部久仁一, 山本恵司
- Organizer
  日本薬剤学会第29年会
- Place of Presentation
  埼玉
- Year and Date
  2014-05-20
- Data Source
  KAKENHI-PROJECT-25460032
[Presentation] HRMAS NMR測定による過飽和溶液中の抗炎症薬メフェナム酸とEudragit E POの分子間相互作用の検出2014
- Author(s)
  東　顕二郎，山本　和俊，Manoj Kumar Pandey，Kamal H. Mroue，森部久仁一，山本恵司，Ayyalusamy Ramamoorthy
- Organizer
  第55回固体NMR・材料フォーラム
- Place of Presentation
  神奈川
- Year and Date
  2014-05-15
- Data Source
  KAKENHI-PROJECT-24790041
[Presentation] 有機ナノチューブに封入されたIbuprofenの溶解性評価2014
- Author(s)
  劉　楠、東　顕二郎、森部　久仁一、丁　武孝、亀田　直弘、増田　光俊、清水　敏美、山本　恵司
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-25460032
[Presentation] Effect of phenytoin/Eudragit S 100 miscibility in solid dispersion on drug and polymer dissolution rates2014
- Author(s)
  Higashi, K., Hayashi, H., Yamamoto, K., Moribe, K.
- Organizer
  PharmaTech2014
- Place of Presentation
  バンコク、タイ
- Year and Date
  2014-12-02
- Data Source
  KAKENHI-PROJECT-24790041
[Presentation] 混合粉砕及び加熱によるサリチル酸のPEG/a-CD-PPRXへの封入2014
- Author(s)
  小川　茉里奈, 東顕二郎, 山本恵司, 森部久仁一
- Organizer
  第31回シクロデキストリンシンポジウム
- Place of Presentation
  島根
- Year and Date
  2014-09-11
- Data Source
  KAKENHI-PROJECT-25460032
[Presentation] HRMAS NMR測定による過飽和溶液中のメフェナム酸とEudragit E POの分子間相互作用の評価2014
- Author(s)
  東　顕二郎，山本　和俊，Manoj Kumar Pandey，Kamal H. Mroue，森部久仁一，山本恵司，Ayyalusamy Ramamoorthy
- Organizer
  日本薬剤学会第29年会
- Place of Presentation
  埼玉
- Year and Date
  2014-05-22
- Data Source
  KAKENHI-PROJECT-24790041
[Presentation] Nitrazepam/Eudragit E PO/Saccharin過飽和溶液の分子状態評価2014
- Author(s)
  金屋　晴信、東　顕二郎、山本　恵司、森部　久仁一
- Organizer
  日本薬学会関東支部大会第61回
- Place of Presentation
  東京
- Year and Date
  2014-10-04
- Data Source
  KAKENHI-PROJECT-24790041
[Presentation] 薬物結晶化抑制作用に及ぼすHPMC-AS置換基比率の影響：溶液NMRによる評価2013
- Author(s)
  植田圭祐、東顕二郎、森部久仁一、山本恵司
- Organizer
  製剤機械技術学会第23回大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24590045
[Presentation] Suspended-state及びsolution-state NMRによる piroxicamナノ微粒子懸濁液の分子状態評価2013
- Author(s)
  長谷川友紀, 東顕二郎, 森部久仁一, 山本恵司
- Organizer
  第19回創剤フォーラム若手研究会
- Place of Presentation
  千葉
- Data Source
  KAKENHI-PROJECT-24790041
[Presentation] 異なる内側表面構造をもつ有機ナノチューブへのIbuprofenの封入検討2013
- Author(s)
  劉楠、東顕二郎、森部久仁一、丁武孝、亀田直弘、増田光俊、清水敏美、山本恵司
- Organizer
  日本薬剤学会第28年会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-25460032
[Presentation] 置換基比率の異なる各種HPMC-ASによる結晶化抑制作用の比較2013
- Author(s)
  植田圭祐、東顕二郎、森部久仁一、山本恵司
- Organizer
  第30回製剤と粒子設計シンポジウム
- Place of Presentation
  岐阜
- Data Source
  KAKENHI-PROJECT-24590045
[Presentation] Investigation of stabilization mechanism of piroxicam nanosuspension by means of suspension-state NMR spectroscopy.2013
- Author(s)
  Hasegawa, Y., Higashi, K., Moribe, K., Yamamoto, K.
- Organizer
  The 10th International Symposium on Agglomeration
- Place of Presentation
  兵庫
- Data Source
  KAKENHI-PROJECT-24790041
[Presentation] Solution NMR study of permeation mechanism of carbamazepine from supersaturated and solubilized solution2013
- Author(s)
  K. Ueda, K. Moribe, K. Higashi, K. Yamamoto
- Organizer
  The 5th Asian Arden Conference
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-24590045
[Presentation] ASC-DP含有率の高いASC-DP/DSPE-PEGナノ微粒子の調製及び構造評価2013
- Author(s)
  設樂竜平、壬生総子、東顕二郎、森部久仁一、山本恵司
- Organizer
  日本薬剤学会第28年会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-25460032
[Presentation] Piroxicamナノ微粒子懸濁液の分子状態評価2013
- Author(s)
  長谷川友紀, 東顕二郎, 森部久仁一, 山本恵司
- Organizer
  日本薬剤学会第28年会
- Place of Presentation
  愛知
- Data Source
  KAKENHI-PROJECT-24790041
[Presentation] 過飽和溶液中におけるHPMC及びPVPによるフェニトイン誘導体結晶化抑制メカニズムの解明2013
- Author(s)
  大塚直哉、植田圭祐、清水梢、片山和明、熊本卓哉、東顕二郎、森部久仁一、山本恵司
- Organizer
  第30回製剤と粒子設計シンポジウム
- Place of Presentation
  岐阜
- Data Source
  KAKENHI-PROJECT-24590045
[Presentation] ASC-DPナノ微粒子形成に及ぼすDSPE-PEGの影響2013
- Author(s)
  設樂竜平、壬生総子、東顕二郎、森部久仁一、山本恵司
- Organizer
  第57回日本薬学会関東支部
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-25460032
[Presentation] 1H-NMRによるCarbamazepine/HPMC-AS過飽和溶液中の薬物分子状態の解明2012
- Author(s)
  植田圭祐、Waree Limwikrant、東顕二郎、森部久仁一、山本恵司
- Organizer
  日本薬剤学会第27年会
- Place of Presentation
  兵庫
- Data Source
  KAKENHI-PROJECT-24790041
[Presentation] 混合粉砕と加熱によるCD-polypseudorotaxane同士で形成される空間への薬物封入2012
- Author(s)
  並木祥恵、WareeLimwikrant、東顕二郎、森部久仁一、山本恵司
- Organizer
  日本薬剤学会第27年会
- Place of Presentation
  兵庫
- Data Source
  KAKENHI-PROJECT-23659017
[Presentation] 医薬品ナノ微粒子の構造・分子状態の評価2012
- Author(s)
  東顕二郎
- Organizer
  大学連携研究設備ネットワーク研究成果報告会
- Place of Presentation
  東京大学本郷キャンパス
- Year and Date
  2012-01-27
- Data Source
  KAKENHI-PROJECT-21790032
[Presentation] 過飽和溶液中でのHPMC-ASによるCarbamazepine結晶化抑制メカニズムの解明2012
- Author(s)
  植田圭祐、東顕二郎、森部久仁一、山本恵司
- Organizer
  第29回製剤と粒子設計シンポジウム
- Place of Presentation
  豊橋
- Data Source
  KAKENHI-PROJECT-24590045
[Presentation] FSM細孔内のインドメタシン着色メカニズムの検討2012
- Author(s)
  東顕二郎、田邉修一、WareeLimwikrant、森部久仁一、山本恵司
- Organizer
  日本薬学会第132年会
- Place of Presentation
  北海道
- Data Source
  KAKENHI-PROJECT-23659017
[Presentation] FSM細孔内のインドメタシン着色メカニズムの検討2012
- Author(s)
  東顕二郎
- Organizer
  第132回日本薬学会
- Place of Presentation
  北海道大学、北海道
- Year and Date
  2012-03-30
- Data Source
  KAKENHI-PROJECT-21790032
[Presentation] FSM細孔内のインドメタシン着色メカニズムの検討2012
- Author(s)
  東顕二郎
- Organizer
  日本薬学会第132年会
- Place of Presentation
  北海道大学、北海道
- Data Source
  KAKENHI-PROJECT-23659017
[Presentation] 混合粉砕によるpiroxicamのPEG/-CD-polypseudorotaxaneへの封入2012
- Author(s)
  並木祥恵、Waree Limwikrant、東顕二郎、森部久仁一、山本恵司
- Organizer
  第29回シクロデキストリンシンポジウム
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23659017
[Presentation] FSM細孔内のインドメタシン着色メカニズムの検討2012
- Author(s)
  東顕二郎
- Organizer
  第132回日本薬学会
- Place of Presentation
  北海道大学
- Year and Date
  2012-03-30
- Data Source
  KAKENHI-PROJECT-21790032
[Presentation] 1H-NMRによるCarbamazepine/HPMC-AS過飽和溶液中の薬物分子状態の解明2012
- Author(s)
  植田圭祐、Waree Limwikrant、東顕二郎、森部久仁一、山本恵司
- Organizer
  日本薬剤学会第27年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-24590045
[Presentation] NMR測定に寄るStevia-Gの自己集合構造及び薬物溶解性改善メカニズムの解明2012
- Author(s)
  6. 東顕二郎、Junying Zhang、戸塚裕一、Waree Limwikrant、森部久仁一、竹内洋文、山本恵司
- Organizer
  日本薬剤学会第27年会
- Place of Presentation
  兵庫
- Data Source
  KAKENHI-PROJECT-24790041
[Presentation] 医薬品ナノ微粒子の構造・分子状態の評価2012
- Author(s)
  東顕二郎
- Organizer
  大学連携研究設備ネットワーク研究成果報告会
- Place of Presentation
  東京大学本郷キャンパス東京(招待講演)
- Year and Date
  2012-01-27
- Data Source
  KAKENHI-PROJECT-21790032
[Presentation] 混合粉砕によるpiroxicamのPEG/・-CD-polypseudorotaxaneへの封入2012
- Author(s)
  並木祥恵、WareeLimwikrant、東顕二郎、森部久仁一、山本恵司
- Organizer
  第29回シクロデキストリンシンポジウム
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23659017
[Presentation] 過飽和溶液中でのHPMC-ASによるCarbamazepine結晶化抑制メカニズムの解明2012
- Author(s)
  植田圭祐、東顕二郎、森部久仁一、山本恵司
- Organizer
  第29回製剤と粒子設計シンポジウム
- Place of Presentation
  愛知
- Data Source
  KAKENHI-PROJECT-24790041
[Presentation] 有機ナノチューブを用いたヒドロコルチゾンの溶解性改善2012
- Author(s)
  牧島隆史、東顕二郎、WareeLimwikrant、森部久仁一、丁武考、増田光俊、清水敏美、山本恵司
- Organizer
  日本薬学会第132年会
- Place of Presentation
  北海道
- Data Source
  KAKENHI-PROJECT-23659017
[Presentation] 混合粉砕と加熱によるCD-polypseudorotaxane 同士で形成される空間への薬物封入2012
- Author(s)
  並木祥恵、Waree Limwikrant、東顕二郎、森部久仁一、山本恵司
- Organizer
  日本薬剤学会第27年会
- Place of Presentation
  兵庫
- Data Source
  KAKENHI-PROJECT-23659017
[Presentation] ^<23>Na MQMAS NMR測定を用いたクロモグリク酸Na擬似多形の識別2011
- Author(s)
  海野真、Waree Limwikrant、東顕二郎、森部久仁一、山本恵司
- Organizer
  日本薬剤学会第26年会
- Place of Presentation
  タワーホール船堀、東京
- Year and Date
  2011-05-29
- Data Source
  KAKENHI-PROJECT-21790032
[Presentation] Structural evaluation of probucol nano suspension by AFM2011
- Author(s)
  K. Moribe, W. Limwikrant, K. Higashi, K. Yamamoto
- Organizer
  AsianFederation for Pharmaceutical Sciences Conference 2011. BO-005
- Place of Presentation
  Kyoto, Japan
- Year and Date
  2011-05-24
- Data Source
  KAKENHI-PROJECT-21590038
[Presentation] ナプロキセンNa水和物中の水の分子状態に関する検討2011
- Author(s)
  東顕二郎
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡県コンベンションアーツセンター
- Year and Date
  2011-03-29
- Data Source
  KAKENHI-PROJECT-21790032
[Presentation] Structural evaluation of probucol nano suspension by AFM2011
- Author(s)
  K.Moribe, W.Limwikrant, K.Higashi, K.Yamamoto.
- Organizer
  Asian Federation for Pharmaceutical Sciences Conference 2011
- Place of Presentation
  Kuala Lumpur, Malaysia
- Year and Date
  2011-12-11
- Data Source
  KAKENHI-PROJECT-21590038
[Presentation] ナプロキセンNa水和物中の水の分子状態に関する検討2011
- Author(s)
  東顕二郎
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡
- Year and Date
  2011-03-29
- Data Source
  KAKENHI-PROJECT-21790032
[Presentation] ^<23>Na固体NMR測定によるナプロキセンNa擬似多形の分子状態の評価:結晶構造データに基づいたNMRスペクトル解析2011
- Author(s)
  東顕二郎
- Organizer
  日本薬剤学会第26年会
- Place of Presentation
  タワーホール船堀、東京
- Year and Date
  2011-05-29
- Data Source
  KAKENHI-PROJECT-21790032
[Presentation] <23>^Na固体NMR測定によるナプロキセンNa擬似多形の分子状態の評価:結晶構造データに基づいたNMRスペクトル解析2011
- Author(s)
  東顕二郎
- Organizer
  日本薬剤学会第26年会
- Place of Presentation
  タワーホール船堀
- Year and Date
  2011-05-29
- Data Source
  KAKENHI-PROJECT-21790032
[Presentation] Preparation and physicochemical characterization of ofloxacin-dicarboxylic acid complex2011
- Author(s)
  K.Moribe, W.Limwikrant, K.Higashi, K.Yamamoto
- Organizer
  International Congress of Analytical Sciences 2011
- Place of Presentation
  Kyoto, Japan
- Year and Date
  2011-05-24
- Data Source
  KAKENHI-PROJECT-21590038
[Presentation] Structural investigation of supersaturated solution from solid dispersion of mefenamic acid and Eudragit EPO2011
- Author(s)
  K. Moribe, T. Kojima, K. Higashi, T. Suzuki, K. Tomono., K. Yamamoto
- Organizer
  International Symposium on BA/BE of Oral Drug Products. P11
- Place of Presentation
  Kobe, Japan
- Year and Date
  2011-07-01
- Data Source
  KAKENHI-PROJECT-21590038
[Presentation] NMR法を用いた懸濁液中に存在するProbucolナノ微粒子の分子状態の評価2011
- Author(s)
  東顕二郎
- Organizer
  第28回製剤と粒子設計シンポジウム
- Place of Presentation
  ホテルニューオータニ大阪大阪
- Year and Date
  2011-10-27
- Data Source
  KAKENHI-PROJECT-21790032
[Presentation] NMR法を用いた懸濁液中に存在するProbucolナノ微粒子の分子状態の評価2011
- Author(s)
  東顕二郎
- Organizer
  第28回製剤と粒子設計シンポジウム
- Place of Presentation
  ホテルニューオータニ大阪
- Year and Date
  2011-10-27
- Data Source
  KAKENHI-PROJECT-21790032
[Presentation] アスコルビン酸誘導体/DSPE-PEGナノ微粒子の構造評価及び細胞障害性2010
- Author(s)
  森部久仁一, 壬生総子, 齋藤謙悟, 東顕二郎, 白澤浩, 山本恵司
- Organizer
  第26回日本DDS学会2-B-23
- Place of Presentation
  大阪
- Year and Date
  2010-06-18
- Data Source
  KAKENHI-PROJECT-21590038
[Presentation] EVALUATION OF DRUG NANOPARTICLES IN SOLID AND SDSPENSION BY HIGH RESOLUTION SEM AND LIQUID AFM2010
- Author(s)
  K.Moribe, C.Wanawongthai, K.Higashi, K.Yamamoto
- Organizer
  AAPS-FIP World Congress 2010
- Place of Presentation
  New Orleans, USA
- Year and Date
  2010-11-19
- Data Source
  KAKENHI-PROJECT-21590038
[Presentation] 固体NMRの製剤学的応用2010
- Author(s)
  東顕二郎
- Organizer
  第13回固体NMR交流会
- Place of Presentation
  千葉大学
- Year and Date
  2010-03-17
- Data Source
  KAKENHI-PROJECT-21790032
[Presentation] 3成分シクロデキストリセ複合体形成によるflurbiprofenの溶出制御2010
- Author(s)
  東顕二郎, 出浦小織, 森部久仁一, 山本恵司
- Organizer
  第27回シクロデキストリンシンポジウム
- Place of Presentation
  金沢市文化ホール
- Year and Date
  2010-09-06
- Data Source
  KAKENHI-PROJECT-21590038
[Presentation] 薬物/(PEG-v-CD-polypseudorotaxane)複合体の構造変化が薬物の分子状態に及ぼす影響2010
- Author(s)
  藁谷美香, 東顕二郎, 森部久仁一, 山本恵司
- Organizer
  第27回シクロデキストリンシンポジウム
- Place of Presentation
  金沢市文化ホール
- Year and Date
  2010-09-06
- Data Source
  KAKENHI-PROJECT-21590038
[Presentation] 固体NMRの製剤学的応用2010
- Author(s)
  東顕二郎
- Organizer
  第13回固体NMR交流会
- Place of Presentation
  千葉
- Year and Date
  2010-03-17
- Data Source
  KAKENHI-PROJECT-21790032
[Presentation] Evaluation of Drug Nanoparticles in Aqueous Solution by AFM Image and Force Curve Analysis2010
- Author(s)
  K. Moribe, A. Ogino, K. Higashi, K. Yamamoto
- Organizer
  FIP Pharmaceutical Sciences 2010 World Congress, New Orleans, M1329
- Place of Presentation
  LA, USA
- Year and Date
  2010-11-15
- Data Source
  KAKENHI-PROJECT-21590038
[Presentation] Drug-loaded ascorbyl dipalmitate/DSPE-PEG nanoparticulate system2009
- Author(s)
  S. Maruyama, K. Moribe, T. Suzuki, K. Tomono, K. Higashi, K. Yamamoto
- Organizer
  11^<th>International Symposium on Microencapsulation
- Place of Presentation
  Naogya,Japan
- Year and Date
  2009-09-30
- Data Source
  KAKENHI-PROJECT-21590038
[Presentation] Ascorbyl dipalmitate/DSPE-PEG nanoparticulate system as a novel drug delivery carrier2009
- Author(s)
  K. Moribe, S. Maruyama, K. Higashi, K. Yamamoto
- Organizer
  2009 American Association Pharmaceutical Sciences Annual Meeting and Exposition,W4246, Los angles
- Place of Presentation
  California, USA
- Year and Date
  2009-11-11
- Data Source
  KAKENHI-PROJECT-21590038
[Presentation] <23>^Na-固体NMR測定によるナプロキセンNa水和物の評価2009
- Author(s)
  東顕二郎
- Organizer
  第26回製剤と粒子設計シンポジウム
- Place of Presentation
  グランドプリンスホテル広島
- Year and Date
  2009-11-27
- Data Source
  KAKENHI-PROJECT-21790032
[Presentation] A Novel Complex Formation of salicylic acid and Y-cyclodextrin-polypseudorotaxane2009
- Author(s)
  K. Higashi, H. Waraya, K. Moribe, K. Yamamoto
- Organizer
  Asian Federation for Pharmaceutical Sciences
- Place of Presentation
  Fukuoka, Japan
- Year and Date
  2009-10-17
- Data Source
  KAKENHI-PROJECT-21590038
[Presentation] Physicochemical characterization of phenytoin derivative nanoparticles prepared by cogrinding2009
- Author(s)
  K. Moribe, A. Ogino, K. Higashi, K. Yamamoto
- Organizer
  Pharmaceutical Sciences
- Place of Presentation
  Fukuoka, Japan
- Year and Date
  2009-10-17
- Data Source
  KAKENHI-PROJECT-21590038
[Presentation] ^<23>Na-固体NMR測定によるナプロキセンNa水和物の評価2009
- Author(s)
  東顕二郎
- Organizer
  第26回製剤と粒子設計シンポジウム
- Place of Presentation
  広島
- Year and Date
  2009-11-27
- Data Source
  KAKENHI-PROJECT-21790032
[Presentation] Drug-loaded Ascorbyl dipalmitate/DSPE-PEG nanoparticulate system2009
- Author(s)
  K.Moribe, S.Maruyama, K.Higashi, Y.Tozuka, K.Yamamoto
- Organizer
  17^<th> International Symposium of Microencapsulation
- Place of Presentation
  Nagoya, Japan
- Year and Date
  2009-09-29
- Data Source
  KAKENHI-PROJECT-21590038
[Presentation] PHYSICOCHEMICAL CHARACTERIZATION OF PHENYTOIN DERIVATIVE NANOPARTICLES PREPARED BY COGRINDING2009
- Author(s)
  K.Moribe, A.Ogino, K.Higashi, K.Yamamoto
- Organizer
  Asian Federation of Pharmaceutical Science
- Place of Presentation
  Fukuoka, Japan
- Year and Date
  2009-10-17
- Data Source
  KAKENHI-PROJECT-21590038
[Presentation] Evaluation of Sodium Naproxen Hydrates by ^<23>Na-MQ-MAS NMR Spectroscopy2009
- Author(s)
  Kenjirou Higashi
- Organizer
  American Association of Pharmaceutical Sciences 2009
- Place of Presentation
  Los Angeles, USA
- Year and Date
  2009-11-17
- Data Source
  KAKENHI-PROJECT-21790032
[Presentation] HPMC及びPVPの薬物結晶化抑制機構の違いが膜透過性に及ぼす影響
- Author(s)
  大塚直哉, 植田圭祐, 清水梢, 片川和明, 熊本卓也, 東顕二郎, 山本恵司, 森部久仁一
- Organizer
  製剤機械技術学会第24回大会
- Place of Presentation
  名古屋
- Year and Date
  2014-10-08 – 2014-10-09
- Data Source
  KAKENHI-PROJECT-24590045
[Presentation] Phenytoin/Eudragit S100 固体分散体の物性と溶出挙動との関連
- Author(s)
  林大基、東顕二郎、森部久仁一、山本恵司
- Organizer
  第57回日本薬学会関東支部大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24590045
[Presentation] HPMC-AS の薬物結晶化抑制作用に及ぼす胆汁酸及び脂質の影響
- Author(s)
  植田圭祐, 東顕二郎, 片岡誠, 山下伸二, 山本恵司, 森部久仁一
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-26 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-24590045
[Presentation] Phenytoin過飽和溶液のCaco-2細胞透過改善メカニズムの解明
- Author(s)
  大塚直哉、植田圭祐、清水梢、片山和明、熊本卓哉、東顕二郎、森部久仁一、山本恵司
- Organizer
  第57回日本薬学会関東支部大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24590045

1. MORIBE Kunikazu (50266350)

# of Collaborated Projects: 12 results

# of Collaborated Products: 185 results
2. 植田圭祐 (40755972)

# of Collaborated Projects: 6 results

# of Collaborated Products: 91 results
3. YAMAMOTO Keiji (50110341)

# of Collaborated Projects: 4 results

# of Collaborated Products: 72 results
4. LIMWIKRANT Waree (50595907)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
5. Itai Shigeru (80453059)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
6. 岩尾康範 (30433022)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
7. 近藤啓 (10825110)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
8. 木村晋一郎 (20791338)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
9. 米持悦生 (40201090)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 福澤薫 (50718244)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 森田剛 (80332633)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. 墨智成 (40345955)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 今村比呂志 (40552485)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
14. SEKINE Shuichi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. HORIE Toshiharu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 西川恵子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 戸塚裕一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Higashi Kenjirou 東 顕二郎

HIGASHI Kenjirou 東 顕二郎

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Co-Researchers

Elucidation of destabilization mechanism of drug amorphous nanosuspension for middle-molecule drug developmentPrincipal Investigator

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Structural evaluation of solid-liquid interface of drug nanoamorphous by suspended-state NMRPrincipal Investigator

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Design of drug amorphous nanosuspension to achieve a pharmaceutical formulation of poorly water-soluble drugPrincipal Investigator

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Evaluation of molecular state of drug nanosuspensions by suspended-state NMR spectroscopyPrincipal Investigator

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In situ suspended state NMR investigation into a solid dipersion after dispersed into waterPrincipal Investigator

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Higashi Kenjirou 東顕二郎

HIGASHI Kenjirou 東顕二郎

[Book] ナノ・マイクロ微粒子の分散評価技術　核磁気共鳴（分担）2020

[Book] 最新製剤学　第11版2018

[Book] 固体医薬品の物性評価　第2版2018

[Book] 医薬ジャーナル：各種ポリマーによる難水溶性薬物の溶解性改善機構の解明と製剤化への応用 (特集実用可能な新しい製剤技術の進歩と将来展望)2014