KANNO Yuichiro 菅野裕一朗

Researcher Number	40453849
Other IDs
Affiliation (based on the past Project Information) *help	2020 – 2021: 静岡県立大学, 薬学部, 講師 2011 – 2019: 東邦大学, 薬学部, 講師 2008 – 2009: Toho University, 薬学部, 講師
Review Section/Research Field	Principal Investigator Environmental and hygienic pharmacy / Basic Section 47030:Pharmaceutical hygiene and biochemistry-related / Biological pharmacy / Environmental pharmacy Except Principal Investigator Natural medicines / Chemical pharmacy
Keywords	Principal Investigator 核内受容体 / 薬学 / 薬物代謝酵素 / 遺伝子発現調節 / 転写因子 / エピジェネティック / 構成的アンドロスタン受容体 / 転写共役因子 / 衛生薬学 / ホルモン … More / 薬物代謝調節 / 転写調節 / 発現制御 / cytochrome p450 / エピジェネティクス / 異物代謝 / 受容体型転写因子 / cytochrome P450 / cofactor / cytochrme P450 / CAR / Nuclear receptor / 生体外異物 / 環境・衛生系薬学 / 環境毒性学 / 環境衛生系薬学 / 代謝調節 / 分子生物学 / バイオアッセイ / シグナル伝達 … More Except Principal Investigator マイクロアレイ / 痴呆 / 遺伝子発現解析 / 発現制御 / 疾患モデル動物 / 遺伝子発現 / 疾患予防 / 農林水産物 / 神経科学 / アルツハイマー病 / 認知症 / 脳神経疾患 / lignan / Trichosanthes　kirilowii / tetrahydrofuran lignan / がん幹細胞抑制活性 / Cancer stem cells / Mammosphere formation / Trichosanthes kirilowii / Euphorbia fischeriana / Saururus chinensis / リガンド / CCC-coupling / カップリング / フラノン / ジアリールケトン / ジヘテロアリールケトン / 5-メトキシ-3(2H)-フラノン / CCC-coupling反応 / カルボニル化 / ビスオキサゾリン / パラジウム Less

The mechanism of selective gene regulation by selective nuclear receptor modulatorsPrincipal Investigator
- Principal Investigator
  
  Kanno Yuichiro
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  University of Shizuoka
  Toho University
Basic research for application of nobiletin, a citrus peel constituent, in improvement and/or prevention of dementia
- Principal Investigator
  
  NEMOTO Kiyomitsu
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Natural medicines
- Research Institution
  Toho University
The mechanism of selective gene regulation Xenobiotic receptor CARPrincipal Investigator
- Principal Investigator
  
  KANNO Yuichiro
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Environmental and hygienic pharmacy
- Research Institution
  Toho University
Investigation of new anti-cancer agents with selective anti-proliferative activities
- Principal Investigator
  
  ASADA Yoshihisa
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Natural medicines
- Research Institution
  Tokyo University of Science
Regulation mechanism of drug metabolism enzymes by SCARM and dual ligand of CAR/PXRPrincipal Investigator
- Principal Investigator
  
  KANNO Yuichiro
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Environmental and hygienic pharmacy
- Research Institution
  Toho University
Development of new tandem reactions by using bis(oxazoline) ligands
- Principal Investigator
  
  KATO Keisuke
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Toho University
Activation mechanism of nuclear receptor CAR by xenobiotics and CAR-mediated disruption of energy metabolismPrincipal Investigator
- Principal Investigator
  
  KANNO Yuichiro
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Toho University
Studies on the activation mechanism of xenobiotic-responsive nuclear receptor CAR and establishment of in vitro evaluation system for its ligandsPrincipal Investigator
- Principal Investigator
  
  KANNO Yuichiro
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Environmental pharmacy
- Research Institution
  Toho University

All 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 Other

All Journal Article Presentation

[Journal Article] Polycyclic aromatic hydrocarbons induce CYP3A5 gene expression via aryl hydrocarbon receptor in HepG2 cells2021
- Author(s)
  Yamashita Naoya、Kanno Yuichiro、Yoshikawa Minami、Ozawa Moeno、Sanada Noriko、Nemoto Kiyomitsu、Kizu Ryoichi
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 46 Issue: 1 Pages: 25-29
- DOI
  10.2131/jts.46.25
- NAID
  130007966023
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07090, KAKENHI-PROJECT-19K23811
[Journal Article] Antiepileptic Drug?Activated Constitutive Androstane Receptor Inhibits Peroxisome Proliferator?Activated Receptorαand Peroxisome Proliferator?Activated ReceptorγCoactivator 1α?Dependent Gene Expression to Increase Blood Triglyceride Levels2020
- Author(s)
  Shizu Ryota、Otsuka Yuta、Ezaki Kanako、Ishii Chizuru、Arakawa Shingo、Amaike Yuto、Abe Taiki、Hosaka Takuomi、Sasaki Takamitsu、Kanno Yuichiro、Miyata Masaaki、Yamazoe Yasushi、Yoshinari Kouichi
- Journal Title
  
  Molecular Pharmacology
  
  Volume: 98 Issue: 5 Pages: 634-647
- DOI
  10.1124/molpharm.120.000103
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07090, KAKENHI-PROJECT-20K07202
[Journal Article] Aryl hydrocarbon receptor counteracts pharmacological efficacy of doxorubicin via enhanced AKR1C3 expression in triple negative breast cancer cells2019
- Author(s)
  Yamashita Naoya、Kanno Yuichiro、Saito Nao、Terai Kensuke、Sanada Noriko、Kizu Ryoichi、Hiruta Nobuyuki、Park Youngjin、Bujo Hideaki、Nemoto Kiyomitsu
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 516 Issue: 3 Pages: 693-698
- DOI
  10.1016/j.bbrc.2019.06.119
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07090
[Journal Article] Identification of 10-dehydrooxyglycyuralin E as a selective human estrogen receptor alpha partial agonist2019
- Author(s)
  Saito Nao、Kawase Keiko、Yamashita Naoya、Tang Yingzhan、Wang Ying、Wang Jian、Liu Yongxiang、Li Ning、Li Wei、Cheng Mao-Sheng、Koike Kazuo、Kanno Yuichiro、Nemoto Kiyomitsu
- Journal Title
  
  Bioorganic Chemistry
  
  Volume: 88 Pages: 102977-102977
- DOI
  10.1016/j.bioorg.2019.102977
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07090
[Journal Article] Cell Cycle and Apoptosis Regulator 1, CCAR1, Regulates Enhancer-Dependent Nuclear Receptor CAR Transactivation2018
- Author(s)
  Kanno Yuichiro、Zhao Shuai、Yamashita Naoya、Saito Nao、Ujiie Aoi、Iijima Rie、Kikawa Nami、Nemoto Kiyomitsu、Inouye Yoshio
- Journal Title
  
  Molecular Pharmacology
  
  Volume: 95 Issue: 1 Pages: 120-126
- DOI
  10.1124/mol.118.114272
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08351
[Journal Article] Heregulin-induced cell migration is promoted by aryl hydrocarbon receptor in HER2-overexpressing breast cancer cells2018
- Author(s)
  Yamashita Naoya、Saito Nao、Zhao Shuai、Terai Kensuke、Hiruta Nobuyuki、Park Youngjin、Bujo Hideaki、Nemoto Kiyomitsu、Kanno Yuichiro
- Journal Title
  
  Experimental Cell Research
  
  Volume: 366 Issue: 1 Pages: 34-40
- DOI
  10.1016/j.yexcr.2018.02.033
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08351
[Journal Article] Alisol B 23-acetate from the rhizomes of Alisma orientale is a natural agonist of the human pregnane X receptor.2017
- Author(s)
  Kanno Y, Yatsu T, Yamashita N, Zhao S, Li W, Imai M, Kashima M, Inouye Y, Nemoto K, Koike K.
- Journal Title
  
  Phytomedicine.
  
  Volume: 26 Pages: 22-27
- DOI
  10.1016/j.phymed.2017.01.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08351
[Journal Article] Tripartite Motif Containing 24 Acts as a Novel Coactivator of the Constitutive Active/Androstane Receptor2017
- Author(s)
  Kanno Yuichiro、Kure Yuki、Kobayashi Saori、Mizuno Mariko、Tsuchiya Yumi、Yamashita Naoya、Nemoto Kiyomitsu、Inouye Yoshio
- Journal Title
  
  Drug Metabolism and Disposition
  
  Volume: 46 Issue: 1 Pages: 46-52
- DOI
  10.1124/dmd.117.077693
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08351
[Journal Article] Differences in Gene Regulation by Dual Ligands of Nuclear Receptors Constitutive Androstane Receptor (CAR) and Pregnane X Receptor (PXR) in HepG2 Cells Stably Expressing CAR/PXR.2016
- Author(s)
  Kanno Y, Tanuma N, Yazawa S, Zhao S, Inaba M, Nakamura S, Nemoto K, Inouye Y.
- Journal Title
  
  Drug Metab Dispos.
  
  Volume: 44 Issue: 8 Pages: 1158-1163
- DOI
  10.1124/dmd.116.070888
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16K08351
[Journal Article] Picrasidine N Is a Subtype-Selective PPARβ/δ Agonist.2016
- Author(s)
  Zhao S, Kanno Y, Li W, Wakatabi H, Sasaki T, Koike K, Nemoto K, Li H.
- Journal Title
  
  J Nat Prod.
  
  Volume: 79 Issue: 4 Pages: 879-885
- DOI
  10.1021/acs.jnatprod.5b00909
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460175
[Journal Article] ent-Atisane diterpenoids from Euphorbia fischeriana inhibit mammosphere formation in MCF-7 cells2016
- Author(s)
  Xinzhu Kuang, Wei Li, Yuichiro Kanno, Naoya Yamashita, Kiyomitsu Nemoto, Yoshihisa Asada, Kazuo Koike
- Journal Title
  
  Journal of Natural Medicines
  
  Volume: 70 Issue: 1 Pages: 120-126
- DOI
  10.1007/s11418-015-0940-6
- NAID
  40020680985
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25460136
[Journal Article] Androgen receptor functions as a negative transcriptional regulator of DEPTOR, mTOR inhibitor2015
- Author(s)
  Kanno Y, Zhao S, Yamashita N, Yanai K, Nemoto K, Inouye Y.
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 40 Issue: 6 Pages: 753-758
- DOI
  10.2131/jts.40.753
- NAID
  130005108863
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25460175
[Journal Article] Protein arginine methyltransferase 5 (PRMT5) is a novel coactivator of constitutive androstane receptor (CAR).2015
- Author(s)
  Kanno Y, Inajima J, Kato S, Matsumoto M, Tokumoto C, Kure Y, Inouye Y.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 459 Issue: 1 Pages: 143-147
- DOI
  10.1016/j.bbrc.2015.02.085
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25460175
[Journal Article] Cycloartane-type triterpenes from Euphorbia fischeriana stimulate human CYP3A4 promoter activity.2014
- Author(s)
  Kuang X, Li W, Kanno Y, Mochizuki M, Inouye Y, Koike K.
- Journal Title
  
  Bioorg Med Chem Lett.
  
  Volume: 24 Pages: 5423-5427
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25460175
[Journal Article] (2)Pd(II)-Catalyzed Ligand Controlled Synthesis of Pyrazole-4-carboxylates and Benzo-[b]thiophene-3-carboxylates2014
- Author(s)
  Y. D. Dhage, H. Daimon, C. Peng, T. Kusakabe, K. Takahashi, Y. Kanno, Y. Inouye, K. Kato
- Journal Title
  
  Org. Biomol Chem.
  
  Volume: 12 Issue: 43 Pages: 8564-8784
- DOI
  10.1039/c4ob01576b
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24590026
[Journal Article] Nigramide C is a natural agonist of human pregnane X receptor2014
- Author(s)
  Kanno Y, Yatsu T, Li W, Koike K, Inouye Y
- Journal Title
  
  Drug metabolism and disposition
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460175
[Journal Article] Nigramie J is a novel potent inverse agonist of the human constitutive androstane receptor2014
- Author(s)
  Yuichiro Kanno, Nobu Tanuma, Tomo Yatsu, Wei Li, Kazuo Koike, Yoshio Inouye
- Journal Title
  
  Pharmacology research & perspectives
  
  Volume: 2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460175
[Journal Article] Nigramide C is a natural agonist of human pregnane x receptor.2014
- Author(s)
  Kanno Y, Yatsu T, Li W, Koike K, Inouye Y.
- Journal Title
  
  Drug Metab Dispos.
  
  Volume: 42 Issue: 6 Pages: 1084-1089
- DOI
  10.1124/dmd.114.057810
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25460175
[Journal Article] Selective Androgen Receptor Modulator, YK11, Regulates Myogenic Differentiation of C2C12 Myoblasts by Follistatin Expression2013
- Author(s)
  Y. Kanno, R. Ota, K. Someya, T. Kusakabe, K. Kato, Y. Inouye
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 36 Issue: 9 Pages: 1460-1465
- DOI
  10.1248/bpb.b13-00231
- NAID
  130003361518
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590026
[Journal Article] A dihydrochalcone and several homoisoflavonoids from Polygonatum odoratum are activators of adenosine monophosphate-activated protein kinase2013
- Author(s)
  Huanjie Guo, Huanxin Zhao, Yuichiro Kanno, Wei Li, Yanling Mu, Xinzhu Kuang, Yoshio Inouye, Kazuo Koike, Haipeng Jiang, Hong Bai
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 23 Issue: 11 Pages: 3137-3139
- DOI
  10.1016/j.bmcl.2013.04.027
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790025, KAKENHI-PROJECT-23790104, KAKENHI-PROJECT-25460175
[Journal Article] Carbonylation of Propargyl Carbamates with Palladium(II) Bisoxazoline Catalysts: Efficient Synthesis of 5-Methyl-3(2H)-furanones2013
- Author(s)
  Kusakabe, T.; Takahashi, T.; Shen, R.; Ikeda, A.; Dhage, Y. D.; Kanno, Y.; Inouye, Y.; Sasai, H.; Mochida, T.; Kato, K.
- Journal Title
  
  Angew. Chem. Int. Ed.
  
  Volume: 52 Issue: 30 Pages: 7845-7849
- DOI
  10.1002/anie.201303684
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-24106726, KAKENHI-PROJECT-24590026, KAKENHI-PROJECT-25460175
[Journal Article] T0901317, a potent LXR agonist, is an inverse agonist of CAR2013
- Author(s)
  Yuichiro Kanno
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 38 Issue: 3 Pages: 309-315
- DOI
  10.2131/jts.38.309
- NAID
  10031158896
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790104
[Journal Article] Selective androgen receptor modulator, YK11, regulates myogenic differentiation of C2C12 myoblasts by follistatin expression2013
- Author(s)
  Kanno Y, Ota R, Someya K, Kusakabe T, Kato K, Inouye Y.
- Journal Title
  
  Biological and pharmaceutica bulletin
  
  Volume: 36 Pages: 1460-1465
- NAID
  130003361518
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460175
[Journal Article] T0901317, a potent LXR agonist, is an inverse agonist of CAR.2013
- Author(s)
  Kanno Y, Tanuma N, Takahashi A, Inouye Y
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 38 Pages: 309-315
- NAID
  10031158896
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460175
[Journal Article] DP97, a DEAD box DNA/RNA helicase, is a target gene-selective co-regulator of the constitutive androstane receptor.2012
- Author(s)
  Yuichiro Kanno
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 426 Issue: 1 Pages: 38-42
- DOI
  10.1016/j.bbrc.2012.08.027
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790104
[Journal Article] Activation of the aryl hydrocarbon receptor represses mammosphere formation in MCF-7 cells.2012
- Author(s)
  Shuai Zhao
- Journal Title
  
  Cancer Lett
  
  Volume: 25 Issue: 2 Pages: 192-198
- DOI
  10.1016/j.canlet.2011.11.025
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790104
[Journal Article] HER2 overexpression-mediated inflammatory signaling enhances mammosphere formation through up-regulation of aryl hydrocarbon receptor transcription.2012
- Author(s)
  Shuai Zhao
- Journal Title
  
  Cancer Lett
  
  Volume: 330 Issue: 1 Pages: 41-48
- DOI
  10.1016/j.canlet.2012.11.021
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790104
[Journal Article] 5-Aminoimidazole-4-carboxamide-1- β-ribofuranoside (AICAR) prevents nuclear translocation of constitutive androstane receptor by AMP-activated protein kinase (AMPK) independent manner.2010
- Author(s)
  Kanno Y, Inouye Y
- Journal Title
  
  J. Toxicol. Sci. (in press)
- NAID
  10026566943
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790114
[Journal Article] The nuclear import of the constitutive androstane receptor by importin/Ran-GTP systems Biochim.2010
- Author(s)
  Kanno Y, Miyazaki Y, Inouye Y
- Journal Title
  
  Biophys. Acta. -Mol Cell Res. (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790114
[Journal Article] Dependence on the microtubule network and heat shock protein 90 of phenobarbital-induced nuclear translocation of the rat constitutive androstane receptor.2010
- Author(s)
  Kanno Y, Miyama Y, Ando M, Inouye Y.
- Journal Title
  
  Molecular Pharmacology 77
  
  Pages: 311-316
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790114
[Journal Article] A consecutive three alanine residue insertion mutant of human CAR : anovel CAR ligand screening system in HepG2 cells2010
- Author(s)
  Kanno Y, Inouye Y.
- Journal Title
  
  Journal of Toxicological Science (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790114
[Journal Article] A consecutive three alanine residues insertion mutant of human CAR: a novel CAR ligand screening system in HepG2 cells2010
- Author(s)
  Kanno Y, Inouye Y
- Journal Title
  
  J. Toxicol. Sci. (in press)
- NAID
  10026566750
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790114
[Journal Article] Dependence on the microtubule network and heat shock protein 90 of phenobarbital-induced nuclear translocation of the rat constitutive androstane receptor.2010
- Author(s)
  Kanno Y, Miyama Y, Ando M, Inouye Y
- Journal Title
  
  Mol. Pharmacol. 77
  
  Pages: 311-316
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790114
[Journal Article] 5-Aminoimidazole-4-carboxamide-1-ss-ribofuranoside (AICAR) prevents nuclear translocation of constitutive androstane receptor by AMP-activated protein kinase (AMPK) independent manner.2010
- Author(s)
  Kanno Y, Inouye Y.
- Journal Title
  
  Journal of Toxicological Science (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790114
[Journal Article] The nuclear import of the constitutive androstane receptor by importin/Ran-GTP systems2010
- Author(s)
  Kanno Y, Miyazaki Y, Inouye Y.
- Journal Title
  
  Biochim.Biophys.Acta.-Mol Cell Research- (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790114
[Presentation] 合成ステロイドYK11及び選択的アンドロゲン受容体調節薬によるAR活性化機構の比較2021
- Author(s)
  小菅友大、菅野裕一朗、保坂卓臣、志津怜太、吉成浩一
- Organizer
  フォーラム2021衛生薬学環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-19K07090
[Presentation] 選択的アンドロゲン受容体調節薬 YK11 による選択的遺伝子発現調節機構2019
- Author(s)
  菅野裕一朗 , 齋藤菜緒 , 日下部太一 , 加藤恵介 , 根本清光
- Organizer
  日本薬学第139年会
- Data Source
  KAKENHI-PROJECT-16K08351
[Presentation] ANGPLT4 遺伝子発現における CAR と PPAR δのクロストーク2019
- Author(s)
  戴維 , 趙帥 , 根本清光 , 菅野裕一朗
- Organizer
  日本薬学第139年会
- Data Source
  KAKENHI-PROJECT-16K08351
[Presentation] 柑橘類成分ノビレチンのthioredoxin-interacting protein遺伝子転写抑制機構2018
- Author(s)
  加賀由里子、池田絢香、菅野裕一朗、粕谷ひかる、大泉康、出川雅邦、根本清光
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-16H05096
[Presentation] 核内受容体CARに対する転写共役因子cell cycle and apoptosis regulator 1(CCAR1)の遺伝子選択的活性調節機構2017
- Author(s)
  氏家　葵, 飯島　理枝, 倉澤　友里恵, 土屋　佑実, 水野　真理子, 根本　清光, 菅野　裕一朗
- Organizer
  日本薬学会第１３７年会
- Place of Presentation
  仙台国際センター(宮城県仙台市)
- Year and Date
  2017-03-25
- Data Source
  KAKENHI-PROJECT-16K08351
[Presentation] CITCOによるCARを介した選択的遺伝子発現調節機構2017
- Author(s)
  土屋　佑実, 小林　沙織, 氏家　葵, 倉澤　友里恵, 水野　真理子, 根本　清光, 菅野　裕一朗
- Organizer
  日本薬学会第１３７年会
- Place of Presentation
  仙台国際センター(宮城県仙台市)
- Year and Date
  2017-03-25
- Data Source
  KAKENHI-PROJECT-16K08351
[Presentation] 核内受容体CARの細胞内局在調節機構2017
- Author(s)
  宇田川有咲，丸茂昂平，野山裕可，木川奈海，根本清光，菅野裕一朗
- Organizer
  フォーラム2017：衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-16K08351
[Presentation] 生体外異物センサーCARと酸化ストレスセンサーNrf2応答系によるAldehyde dehydrogenase1A1(ALDH1A1)発現調節機構2017
- Author(s)
  倉澤　友里恵, 高橋　友美, 氏家　葵, 土屋　佑実, 水野　真理子, 根本　清光, 菅野　裕一朗
- Organizer
  日本薬学会第１３７年会
- Place of Presentation
  仙台国際センター(宮城県仙台市)
- Year and Date
  2017-03-25
- Data Source
  KAKENHI-PROJECT-16K08351
[Presentation] 異物受容体CARの活性調節機構2017
- Author(s)
  菅野裕一朗
- Organizer
  フォーラム2017：衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-16K08351
[Presentation] Tripartite motif-containing 24 (TRIM24)による核内受容体CARの転写活性調節機構2017
- Author(s)
  水野　真理子, 呉　由貴, 氏家　葵, 倉澤　友里恵, 土屋　佑実, 根本　清光, 菅野　裕一朗
- Organizer
  日本薬学会第１３７年会
- Place of Presentation
  仙台国際センター(宮城県仙台市)
- Year and Date
  2017-03-25
- Data Source
  KAKENHI-PROJECT-16K08351
[Presentation] 核内受容体型転写因子 CAR のコアクチベーターとしての Tripartite motif-containing 33 (TRIM33)2016
- Author(s)
  宮下優香 , 宮川ありす , 根本清光 , 菅野裕一朗
- Organizer
  日本薬学会第136年会
- Place of Presentation
  パシフィコ横浜（神奈川県、横浜市）
- Year and Date
  2016-03-29
- Data Source
  KAKENHI-PROJECT-25460175
[Presentation] 核内受容体型転写因子 CAR のコアクチベーターとしての influenza virus nonstructural protein-1 binding protein（IVNS1ABP）2016
- Author(s)
  宮川ありす , 宮下優香 , 根本清光 , 菅野裕一朗
- Organizer
  日本薬学会第136年会
- Place of Presentation
  パシフィコ横浜（神奈川県、横浜市）
- Year and Date
  2016-03-29
- Data Source
  KAKENHI-PROJECT-25460175
[Presentation] Picrasidine N は PPAR デルタの選択的なアゴニストである2016
- Author(s)
  趙帥 , 菅野裕一朗 , 李巍 , 若旅穂奈美 , 佐々木辰憲 , 小池一男 , 根本清光 , 李会成
- Organizer
  日本薬学会第136年会
- Place of Presentation
  パシフィコ横浜（神奈川県、横浜市）
- Year and Date
  2016-03-29
- Data Source
  KAKENHI-PROJECT-25460175
[Presentation] 乳がん細胞における選択的アンドロゲン受容体調節薬YK11による遺伝子発現調節機構2015
- Author(s)
  横田里香, 山田幸奈, 菅野裕一朗, 日下部太一, 加藤恵介, 井上義雄
- Organizer
  日本薬学会第135年会
- Place of Presentation
  デザインクリエイティブセンター神戸(兵庫県・神戸市）
- Year and Date
  2015-03-28
- Data Source
  KAKENHI-PROJECT-24590026
[Presentation] 新規CAR結合タンパク質によるCAR機能調節機構2015
- Author(s)
  呉由貴 , 白石光 , 徳元千香子 , 菅野裕一朗 , 井上義雄
- Organizer
  日本薬学会第１３５年会
- Place of Presentation
  デザインクリエイティブセンター神戸（兵庫県、神戸市）
- Year and Date
  2015-03-28
- Data Source
  KAKENHI-PROJECT-25460175
[Presentation] Steroid receptor coactivator による選択的 CAR 標的遺伝子発現調節機構2015
- Author(s)
  徳元千香子 , 稲葉美季 , 呉由貴 , 白石光 , 菅野裕一朗 , 井上義雄
- Organizer
  日本薬学会第１３５年会
- Place of Presentation
  デザインクリエイティブセンター神戸（兵庫県、神戸市）
- Year and Date
  2015-03-28
- Data Source
  KAKENHI-PROJECT-25460175
[Presentation] デュアルリガンドによる核内受容体 CAR・PXR のクロストーク2015
- Author(s)
  菅野裕一朗 , 井上義雄
- Organizer
  日本薬学会第１３５年会
- Place of Presentation
  デザインクリエイティブセンター神戸（兵庫県、神戸市）
- Year and Date
  2015-03-28
- Data Source
  KAKENHI-PROJECT-25460175
[Presentation] YK11によるFollistatin誘導機構の解明2015
- Author(s)
  谷津智史, 菅野裕一朗, 日下部太一, 加藤恵介, 長濱辰文, 井上義雄
- Organizer
  日本薬学会第135年会
- Place of Presentation
  デザインクリエイティブセンター神戸(兵庫県・神戸市）
- Year and Date
  2015-03-28
- Data Source
  KAKENHI-PROJECT-24590026
[Presentation] 核内受容体CARとPRMT5の相互作用2014
- Author(s)
  菅野　裕一朗、入内島　潤、加藤　さやか、徳元千香子,　呉由貴 , 井上義雄
- Organizer
  フォーラム2014：衛生薬学・環境トキシコロジー
- Place of Presentation
  つくば国際会議場（茨城県、つくば市）
- Year and Date
  2014-09-19
- Data Source
  KAKENHI-PROJECT-25460175
[Presentation] がん幹細胞抑制作用を示すSaururus chinensisの活性成分の同定及び作用機序の解明2014
- Author(s)
  山下直哉, 菅野裕一朗, 佐藤ちひろ, 若井将志, 遠藤慎平, 李巍, 小池一男, 浅田善久, 井上義雄
- Organizer
  第134回日本薬学会年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-25460136
[Presentation] Regulation of nuclear receptor CAR-mediated induction by DP972012
- Author(s)
  Yuichiro Kanno
- Organizer
  日本薬物動態学会第27回年会
- Place of Presentation
  東京
- Year and Date
  2012-11-22
- Data Source
  KAKENHI-PROJECT-23790104
[Presentation] 新規合成ステロイド化合物YK11 のアンドロゲン受容体に対する部分アゴニスト活性2012
- Author(s)
  菅野裕一朗
- Organizer
  第20回日本ステロイドホルモン学会
- Place of Presentation
  金沢
- Year and Date
  2012-11-18
- Data Source
  KAKENHI-PROJECT-23790104
[Presentation] 薬物代謝の誘導に関与する核内受容体CARの機能と活性調節機構2011
- Author(s)
  菅野　裕一朗
- Organizer
  第55回日本薬学会関東支部大会(招待講演)
- Place of Presentation
  東邦大学習志野キャンパス(船橋市)
- Data Source
  KAKENHI-PROJECT-23790104
[Presentation] テトラサイクリン誘導性核内受容体 CAR 発現 HepG2 細胞の樹立と応用2011
- Author(s)
  菅野裕一朗
- Organizer
  2011: 衛生薬学・環境トキシコロジー
- Place of Presentation
  金沢
- Year and Date
  2011-10-28
- Data Source
  KAKENHI-PROJECT-23790104
[Presentation] HER2過剰発現乳がん細胞におけるAhR過剰発現機構2011
- Author(s)
  大原　志織、菅野　裕一朗、井上　義雄
- Organizer
  第55回日本薬学会関東支部大会
- Place of Presentation
  東邦大学習志野キャンパス(船橋市)
- Data Source
  KAKENHI-PROJECT-23790104
[Presentation] テトラサイクリン誘導性核内受容体CAR発現HepG2細胞の樹立と応用2011
- Author(s)
  菅野　裕一朗、入内島　潤、田沼　信明、吉見　昌彦、井上　義雄
- Organizer
  フォーラム2011：衛生薬学・環境トキシコロジー
- Place of Presentation
  金沢エクセルホテル東急(金沢市)
- Data Source
  KAKENHI-PROJECT-23790104
[Presentation] AhRによるサイクリンD1発現調節機構の解析2011
- Author(s)
  牧村　南、趙帥、菅野　裕一朗、井上　義雄
- Organizer
  第55回日本薬学会関東支部大会
- Place of Presentation
  東邦大学習志野キャンパス(船橋市)
- Data Source
  KAKENHI-PROJECT-23790104
[Presentation] 核内受容体CARとタンパク質アルギニンメチル化酵素PRMTの相互作用2011
- Author(s)
  入内島　潤，菅野　裕一朗，井上　義雄
- Organizer
  フォーラム2011：衛生薬学・環境トキシコロジー
- Place of Presentation
  金沢エクセルホテル東急(金沢市)
- Data Source
  KAKENHI-PROJECT-23790104
[Presentation] 薬物代謝酵素の誘導に関与する CAR の機能と活性調節機構2011
- Author(s)
  菅野裕一朗
- Organizer
  第55回日本薬学会関東支部大会
- Place of Presentation
  千葉
- Year and Date
  2011-10-08
- Data Source
  KAKENHI-PROJECT-23790104
[Presentation] 核内受容体CARとHsp60の相互作用解析2011
- Author(s)
  吉見　昌彦，菅野　裕一朗，井上　義雄
- Organizer
  フォーラム2011：衛生薬学・環境トキシコロジー
- Place of Presentation
  金沢エクセルホテル東急(金沢市)
- Data Source
  KAKENHI-PROJECT-23790104
[Presentation] NAD＋依存性脱アセチル化酵素SIRT1による CARの転写活性調節機構への影響2011
- Author(s)
  田沼　信明，菅野　裕一朗，井上　義雄
- Organizer
  フォーラム2011：衛生薬学・環境トキシコロジー
- Place of Presentation
  金沢エクセルホテル東急(金沢市)
- Data Source
  KAKENHI-PROJECT-23790104
[Presentation] AhRによる乳癌細胞増殖抑制機構2011
- Author(s)
  趙帥、菅野　裕一朗、牧村　南、中山　桃香、井上　義雄
- Organizer
  第55回日本薬学会関東支部大会
- Place of Presentation
  東邦大学習志野キャンパス(船橋市)
- Data Source
  KAKENHI-PROJECT-23790104
[Presentation] 異物応答に関与する核内受容体CARの細胞内局在調節機構2010
- Author(s)
  菅野裕一朗、井上義雄
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Year and Date
  2010-03-28
- Data Source
  KAKENHI-PROJECT-20790114
[Presentation] CAR変異体を用いたhuman CARリガンドスクリーニング系の確立と評価(2)2009
- Author(s)
  菅野裕一朗、井上義雄
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Year and Date
  2009-03-28
- Data Source
  KAKENHI-PROJECT-20790114
[Presentation] Suppressive effect of aryl hydrocarbon receptor repressor on transcriptional activity of estrogen receptor alpha2009
- Author(s)
  菅野裕一朗、張淑芸、高根優介、井上義雄
- Organizer
  21th IUBMB International Congress of Biochemistry and Molecular Biology
- Place of Presentation
  上海、中国
- Year and Date
  2009-08-04
- Data Source
  KAKENHI-PROJECT-20790114
[Presentation] PBによる核内受容体CARの核移行における微小管とHsp90の役割2009
- Author(s)
  菅野裕一郎, 深山靖夫, 井上義雄
- Organizer
  フォーラム2009衛生薬学・環境トキシコロジー
- Place of Presentation
  沖縄
- Year and Date
  2009-11-05
- Data Source
  KAKENHI-PROJECT-20790114
[Presentation] The mechanism of spontaneous nuclear translocation of nuclear receptor CAR in cultured cell line2008
- Author(s)
  菅野裕一朗、井上義雄
- Organizer
  第81回日本生化学会大会・第31回日本分子生物学会年会合同大会
- Place of Presentation
  神戸
- Year and Date
  2008-12-09
- Data Source
  KAKENHI-PROJECT-20790114
[Presentation] 核内レセプターCARの核移行メカニズムの解析2008
- Author(s)
  菅野裕一朗、井上義雄
- Organizer
  フォーラム2008衛生薬学・環境トキシコロジー
- Place of Presentation
  熊本
- Year and Date
  2008-10-18
- Data Source
  KAKENHI-PROJECT-20790114
[Presentation] デュアルリガンドによる核内受容体CAR・PXRのクロストーク
- Author(s)
  ◎菅野　裕一朗、矢沢　幸紀、加藤　さやか、松本　茉衣華、田沼　信明、井上　義雄
- Organizer
  フォーラム2013：衛生薬学・環境トキシコロジー
- Place of Presentation
  九州大学医学部百年講堂（福岡県）
- Data Source
  KAKENHI-PROJECT-25460175
[Presentation] 選択的アンドロゲン受容体調節薬YK11によるC2C12細胞筋分化促進機構
- Author(s)
  菅野裕一郎, 巨田留美, 染谷幸祐, 日下部太一, 加藤恵介, 井上義雄
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本市総合体育館（熊本県）
- Data Source
  KAKENHI-PROJECT-24590026
[Presentation] Regulation of nuclear receptor CAR-mediated induction by DP97
- Author(s)
  Yuichiro Kanno
- Organizer
  日本薬物動態学会　第27回年会
- Place of Presentation
  タワーホール船堀（東京）
- Data Source
  KAKENHI-PROJECT-23790104

1. KATO Keisuke (80276609)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
2. KUSAKABE Taichi (00600032)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
3. INOUYE Yoshio (00136053)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
4. ASADA Yoshihisa (90118779)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
5. LI Wei (90328633)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
6. NEMOTO Kiyomitsu (90189366)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. 佐藤忠章 (80287549)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. OHIZUMI yasushi

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. 笹井宏明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KANNO Yuichiro 菅野 裕一朗

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The mechanism of selective gene regulation by selective nuclear receptor modulatorsPrincipal Investigator

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Basic research for application of nobiletin, a citrus peel constituent, in improvement and/or prevention of dementia

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The mechanism of selective gene regulation Xenobiotic receptor CARPrincipal Investigator

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Investigation of new anti-cancer agents with selective anti-proliferative activities

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Regulation mechanism of drug metabolism enzymes by SCARM and dual ligand of CAR/PXRPrincipal Investigator

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Development of new tandem reactions by using bis(oxazoline) ligands

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Activation mechanism of nuclear receptor CAR by xenobiotics and CAR-mediated disruption of energy metabolismPrincipal Investigator

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Studies on the activation mechanism of xenobiotic-responsive nuclear receptor CAR and establishment of in vitro evaluation system for its ligandsPrincipal Investigator

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[Journal Article] Polycyclic aromatic hydrocarbons induce CYP3A5 gene expression via aryl hydrocarbon receptor in HepG2 cells2021

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[Journal Article] Antiepileptic Drug?Activated Constitutive Androstane Receptor Inhibits Peroxisome Proliferator?Activated Receptorαand Peroxisome Proliferator?Activated ReceptorγCoactivator 1α?Dependent Gene Expression to Increase Blood Triglyceride Levels2020

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[Journal Article] Aryl hydrocarbon receptor counteracts pharmacological efficacy of doxorubicin via enhanced AKR1C3 expression in triple negative breast cancer cells2019

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[Journal Article] Identification of 10-dehydrooxyglycyuralin E as a selective human estrogen receptor alpha partial agonist2019

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[Journal Article] Cell Cycle and Apoptosis Regulator 1, CCAR1, Regulates Enhancer-Dependent Nuclear Receptor CAR Transactivation2018

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KANNO Yuichiro 菅野裕一朗