TAKATORI ATSUSHI 高取敦志

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ATSUSHI Takatori 高取敦志

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Researcher Number	40455390
Other IDs
Affiliation (Current)	2025: 千葉県がんセンター(研究所), がんゲノムセンターがん先進治療開発研究室, 室長 2025: 千葉県がんセンター(研究所), がん治療開発グループがん先進治療開発研究室, 室長
Affiliation (based on the past Project Information) *help	2020 – 2025: 千葉県がんセンター(研究所), がん治療開発グループがん先進治療開発研究室, 室長 2018 – 2019: 千葉県がんセンター(研究所), がん治療開発グループ, 室長 2018: 千葉県がんセンター(研究所), がん治療開発グループ, 室長心得 2013 – 2017: 千葉県がんセンター(研究所), がん治療開発グループ, 研究員 2014: 千葉県がんセンター(研究所), がん遺伝創薬研究室, 研究員 … More 2010 – 2013: 千葉県がんセンター(研究所), 小児がん研究センター, 研究員 2009 – 2011: 千葉県がんセンター(研究所), 研究局, 研究員 2008: Chiba Cancer Center (Research Institute), 転移制御研 2007 – 2008: Chiba Cancer Center (Research Institute), 転移制御研究室, 研究員 Less
Review Section/Research Field	Principal Investigator Basic Section 50020:Tumor diagnostics and therapeutics-related / Pediatrics / Basic Section 50010:Tumor biology-related / Tumor therapeutics / Tumor biology Except Principal Investigator Pediatrics / Basic Section 48040:Medical biochemistry-related / Basic Section 50020:Tumor diagnostics and therapeutics-related / Medical genome science
Keywords	Principal Investigator 癌 / ケミカルバイオロジー / シグナル伝達 / 遺伝子増幅 / 増幅遺伝子 / アルキル化剤 / 標的治療 / NLRR / MET / オルガノイド … More / ピロール・イミダゾール・ポリアミド化合物 / 抗がん物質探索 / エピジェネティクス制御化合物 / 融合遺伝子 / ポリアミド化合物 / 軟部肉腫 / 遺伝子改変動物 / NLRR1 / 細胞増殖 / ノックアウトマウス / 小児腫瘍学 / シグナル伝逹 … More Except Principal Investigator アルキル化剤 / ピロールイミダゾールポリアミド / MYCN / 浸潤 / 転移 / 癌 / 細胞間移行 / ミトコンドリアDNA / 受精鶏卵 / KRAS / アミノ基 / PIP-CBI / hTERT / PIポリアミド / 膵線管がん / ゲノム創薬 / ゲノム医学 / ゲノム科学 / 総合生物 / 膵臓がん / KR12 / 膵線管癌 / NCYM / ShcC / ALK / TrkB / in silico screening / 神経芽腫 / 創薬 / NLRR1 / 細胞増殖 / Neuroblastoma / NLRR3 / NLRR2 / NLLRR1 Less

難治性がんの発生原因となる異常なゲノムの増幅領域および反復配列の標的化Principal Investigator
- Principal Investigator
  
  高取敦志
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Chiba Cancer Center (Research Institute)
Analysis of the role of mtDNA mutations in invasion and metastasis using mitochondrial intercellular transfer
- Principal Investigator
  
  越川信子
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48040:Medical biochemistry-related
- Research Institution
  Chiba Cancer Center (Research Institute)
Development of amplified gene-specific alkylator as a novel therapeutic agent using patient-derived organoids from solid tumorsPrincipal Investigator
- Principal Investigator
  
  高取敦志
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Chiba Cancer Center (Research Institute)
Exploring the potential of PIP-CBI derivatives with amino groups as anticancer agents for drug discovery
- Principal Investigator
  
  WATANABE TAKAYOSHI
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Chiba Cancer Center (Research Institute)
Development of amplified gene-selective alkylator as a novel cancer therapeutic agentPrincipal Investigator
- Principal Investigator
  
  Takatori Atsushi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Chiba Cancer Center (Research Institute)
Development of therapeutic strategy using molecules of targeting genomic mutation for pancreatic ductal carcinoma
- Principal Investigator
  
  Watanabe Takayoshi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical genome science
- Research Institution
  Chiba Cancer Center (Research Institute)
Targeting the fusion genes using pyrrole-imidazole polyamides in Ewing and synovial sarcoma cellsPrincipal Investigator
- Principal Investigator
  
  Takatori Atsushi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor therapeutics
- Research Institution
  Chiba Cancer Center (Research Institute)
Molecular mechanism by which NLRR1, a therapeutic target in neuroblastoma, selectively enhances growth signalsPrincipal Investigator
- Principal Investigator
  
  TAKATORI Atsushi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor biology
- Research Institution
  Chiba Cancer Center (Research Institute)
Generation of the MYCN/NCYM mouse model and the drug discovery for human neuroblastoma
- Principal Investigator
  
  NAKAGAWARA Akira
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Pediatrics
- Research Institution
  Kyushu University
  Chiba Cancer Center (Research Institute)
Mechanism of NLRR1-regulated signaling pathway and establishment of a novel targeted therapyPrincipal Investigator
- Principal Investigator
  
  TAKATORI Atsushi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pediatrics
- Research Institution
  Chiba Cancer Center (Research Institute)
Functional analysis of NLRR family genes in neuroblastoma
- Principal Investigator
  
  NAKAGAWARA Akira
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pediatrics
- Research Institution
  Chiba Cancer Center (Research Institute)
Analysis on the function of NLRR family protein in development and tumorigenesisPrincipal Investigator
- Principal Investigator
  
  ATSUSHI Takatori
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (Start-up)
- Research Field
  
  Pediatrics
- Research Institution
  Chiba Cancer Center (Research Institute)

[Journal Article] Use of DNA‐alkylating pyrrole‐imidazole polyamides for anti‐cancer drug sensitivity screening in pancreatic ductal adenocarcinoma2022
- Author(s)
  Tsujimoto Akiko、Matsuo Niina、Lai Xiaoyi、Inoue Takahiro、Yoda Hiroyuki、Lin Jason、Shinozaki Yoshinao、Watanabe Takayoshi、Koshikawa Nobuko、Takatori Atsushi、Nagase Hiroki
- Journal Title
  
  Cancer Medicine
  
  Volume: 12 Issue: 5 Pages: 5821-5832
- DOI
  10.1002/cam4.5359
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07710
[Journal Article] Targeting the mutant PIK3CA gene by DNA-alkylating pyrrole-imidazole polyamide in cervical cancer2021
- Author(s)
  Krishnamurthy S, Yoda H, Hiraoka K, Inoue T, Lin J, Shinozaki Y, Watanabe T, Koshikawa N, Takatori A, Nagase H
- Journal Title
  
  Cancer Science
  
  Volume: 112(3) Issue: 3 Pages: 1141-1149
- DOI
  10.1111/cas.14785
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07767, KAKENHI-PROJECT-20H03540
[Journal Article] Targeting anaplastic lymphoma kinase (ALK) gene alterations in neuroblastoma by using alkylating pyrrole-imidazole polyamides2021
- Author(s)
  Ota Y, Yoda H, Inoue T, Watanabe T, Shinozaki Y, Takatori A, Nagase H
- Journal Title
  
  PLoS One
  
  Volume: 16(9) Issue: 9 Pages: e0257718-e0257718
- DOI
  10.1371/journal.pone.0257718
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07767, KAKENHI-PROJECT-20H03540, KAKENHI-PROJECT-20K07710
[Journal Article] Effects of novel small compounds targeting TrkB on neuronal cell survival and depression-like behavior.2016
- Author(s)
  Fukuda M, Takatori A, Nakamura Y, Suganami A, Hoshino T, Tamura Y, Nakagawara A
- Journal Title
  
  Neurochemistry International
  
  Volume: 97 Pages: 42-48
- DOI
  10.1016/j.neuint.2016.04.017
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25830092, KAKENHI-PROJECT-15K08720, KAKENHI-PROJECT-16K08542
[Journal Article] Identification of novel candidate compounds targeting TrkB to induce apoptosis in neuroblastoma.2014
- Author(s)
  Nakamura Y, Suganami A, Fukuda M, Md. Kamrul Hasan, Yokochi T, Takatori A, Satoh S, Hoshino T, Tamura Y, Nakagawara A.
- Journal Title
  
  Cancer Medcine
  
  Volume: 3 Issue: 1 Pages: 25-35
- DOI
  10.1002/cam4.175
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24249061, KAKENHI-PROJECT-24592703, KAKENHI-PROJECT-25253095, KAKENHI-PROJECT-25460328, KAKENHI-PROJECT-25830092
[Journal Article] NCYM, a Cis-antisense gene of MYCN,　encodes a de novo evolved protein that inhibits GSK3β resulting in the　stabilization of MYCN in human neuroblastomas.2014
- Author(s)
  Suenaga Y, Islam SM, Alagu J, Kaneko Y, Kato M, Tanaka Y, Kawana H, Hossain S,　Matsumoto D, Yamamoto M, Shoji W, Itami M, Shibata T, Nakamura Y, Ohira M,　Haraguchi S, Takatori　A, Nakagawara A.
- Journal Title
  
  PLoS Genet
  
  Volume: 10 Issue: 1 Pages: 1-14
- DOI
  10.1371/journal.pgen.1003996
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23591562, KAKENHI-PROJECT-24249061, KAKENHI-PROJECT-24592703, KAKENHI-PROJECT-24700957, KAKENHI-PROJECT-25830092
[Journal Article] Receptor-type protein tyrosine phosphatasedirectly dephosphorylates CD133 and regulates downstream AKT activation2014
- Author(s)
  Shimozato O, Souda H
- Journal Title
  
  Oncogene
  
  Volume: 34(15) Issue: 15 Pages: 1-12
- DOI
  10.1038/onc.2014.141
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23591978, KAKENHI-PROJECT-24249061, KAKENHI-PROJECT-24390269, KAKENHI-PROJECT-26462721, KAKENHI-PROJECT-15K08412
[Journal Article] Intracellular fragment of NLRR3 (NLRR3-ICD) stimulates ATRA-dependent neuroblastoma differentiation.2014
- Author(s)
  Akter J, Takatori A, Islam MS, Nakazawa A, Ozaki T, Nagase H, Nakagawara A.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 453(1) Issue: 1 Pages: 86-93
- DOI
  10.1016/j.bbrc.2014.09.065
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24249061, KAKENHI-ORGANIZER-25112001, KAKENHI-PROJECT-25830092, KAKENHI-PROJECT-26290060
[Journal Article] Temozolomide suppresses MYC via activation of TAp63 to inhibit progression of human glioblastoma.2013
- Author(s)
  Yamaki T, Suenaga Y, Iuchi T, Alagu J, Takatori A, Itami M, Araki A, Ohira M, Inoue M, Kageyama H, Yokoi S, Saeki N, Nakagawara A.
- Journal Title
  
  Sci Rep.
  
  Volume: 3 Issue: 1 Pages: 1160-1160
- DOI
  10.1038/srep01160
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591562, KAKENHI-PROJECT-24249061, KAKENHI-PROJECT-24592179
[Journal Article] ALK is a MYCN target　gene and regulates cell migration and invasion in neuroblastoma.2013
- Author(s)
  Hasan MK, Nafady A, Takatori A, Kishida S, Ohira M, Suenaga Y, Hossain S,　Akter J, Ogura A, Nakamura Y, Kadomatsu K, Nakagawara A.
- Journal Title
  
  Sci Rep
  
  Volume: 3 Issue: 1 Pages: 3450-3450
- DOI
  10.1038/srep03450
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591562, KAKENHI-PROJECT-24249061, KAKENHI-PROJECT-24590377, KAKENHI-PROJECT-24592703
[Journal Article] Novel adaptor protein Shf interacts with ALK receptor and negatively regulates its downstream signals in neuroblastoma.2013
- Author(s)
  Takagi D
- Journal Title
  
  Cancer Sci
  
  Volume: 104 Issue: 5 Pages: 563-572
- DOI
  10.1111/cas.12115
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591976, KAKENHI-PROJECT-22791507, KAKENHI-PROJECT-23591562, KAKENHI-PROJECT-23592624, KAKENHI-PROJECT-24249061, KAKENHI-PROJECT-24390269
[Journal Article] NLRR1 enhances EGF-mediated MYCN induction in neuroblastoma and accelerates tumor growth in vivo.2012
- Author(s)
  Hossain S
- Journal Title
  
  Cancer Res
  
  Volume: 72 Issue: 17 Pages: 4587-4596
- DOI
  10.1158/0008-5472.can-12-0943
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591976, KAKENHI-PROJECT-22791016, KAKENHI-PROJECT-23592624, KAKENHI-PROJECT-24249061, KAKENHI-PROJECT-24390269, KAKENHI-PROJECT-24590496, KAKENHI-PROJECT-24592703
[Journal Article] Expression of NLRR3 orphan receptor gene is negatively regulated by MYCN and Miz-1, and its down-regulation is associated with unfavorable outcome in neuroblastoma2011
- Author(s)
  Akter J, Takatori A, Hossain S, Ozaki T, Nakazawa A, Ohira M, Suenaga Y, Nakagawara A
- Journal Title
  
  Clin Cancer Res
  
  Volume: 17 Issue: 21 Pages: 6681-6692
- DOI
  10.1158/1078-0432.ccr-11-0313
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390317, KAKENHI-PROJECT-22791016, KAKENHI-PROJECT-23591562
[Journal Article] The Mitogen-activated protein kinase kinase kinase 1 (MAP3K1) integrates developmental signals for evelid closure2011
- Author(s)
  Geh E., Takatori A., 等
- Journal Title
  
  Proc Natl Acad Sci U S A
  
  Volume: 108 Issue: 42 Pages: 17349-17354
- DOI
  10.1073/pnas.1102297108
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22791016
[Journal Article] Differential transmission of MEKK1 morphogenetic signals by JNK1 and JNK22008
- Author(s)
  高取、Geh、Chen、Zhang、Meller、Xia
- Journal Title
  
  Development 135(1)
  
  Pages: 23-32
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19890276
[Journal Article] Differential transmission of MEKK1 morphogenetic signals by JNK1and JNK22008
- Author(s)
  高取敦志、Geh E、Chen L、Zhang L.、 Meller J.、Xia Y
- Journal Title
  
  Development 135(1)
  
  Pages: 23-32
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19890276
[Patent] United States Patent2019
- Inventor(s)
  永瀬浩喜、杉山弘、板東俊和、高取敦志
- Industrial Property Rights Holder
  CHIBA PREFECTURE
- Industrial Property Rights Type
  特許
- Filing Date
  2019
- Acquisition Date
  2020
- Overseas
- Data Source
  KAKENHI-PROJECT-19K07767
[Patent] 抗NLRR1抗体2014
- Inventor(s)
  中川原章、高取敦志
- Industrial Property Rights Holder
  千葉県
- Industrial Property Rights Type
  特許
- Filing Date
  2014-04-25
- Overseas
- Data Source
  KAKENHI-PROJECT-25830092
[Patent] 癌の治療薬のスクリーニング法2008
- Inventor(s)
  中川原章、高取敦志
- Industrial Property Rights Holder
  久光製薬
- Filing Date
  2008-03-04
- Data Source
  KAKENHI-PROJECT-19890276
[Presentation] MYCN増幅神経芽腫細胞において、MYCNを直接標的としたDNA損傷はATR阻害により増強される2023
- Author(s)
  頼　笑疑，高取敦志
- Organizer
  第27回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-22K07245
[Presentation] Use of patient-derived organoids to develop a therapeutic strategy targeting oncogene amplification2023
- Author(s)
  A. Takatori, H. Yoda, Y. Maru, T. Hippo
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-22K07245
[Presentation] Growth inhibition of neuroblastoma cells by anti-NLRR1 monoclonal antibodies2023
- Author(s)
  A. Takatori, MD. Shamim, A. Ogura, J. Akter, Y. Nakamura, A. Nakagawara
- Organizer
  Advances in Neuroblastoma Research 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07245
[Presentation] F1174L 変異 ALK 遺伝子の選択的 DNA アルキル化は神経芽腫において抗腫瘍効果を示す2022
- Author(s)
  高取敦志、太田陽子、養田裕行、井上貴博、渡部隆義、永瀬浩喜
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20K07710
[Presentation] Synergistic effect of ATR inhibition and MYCN-targeted DNA damage in neuroblastoma2022
- Author(s)
  頼笑疑, 高取敦志, 養田裕行, 篠崎喜脩, 渡部隆義, 永瀬浩喜
- Organizer
  第81回日本癌学会学術集会
- Data Source
  KAKENHI-PROJECT-22K07245
[Presentation] ATR阻害とMYCNターゲティングにより、PARP阻害剤非感受性MYCN-amp神経芽腫細胞に高い効果を示した2022
- Author(s)
  頼笑疑, 高取敦志, 養田裕行, 篠崎喜脩, 渡部隆義, 永瀬浩喜
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-22K07245
[Presentation] ATR 阻害剤と神経芽腫において MYCN 標的 DNA 損傷と相乗効果を示す2022
- Author(s)
  頼笑疑、養田裕行、篠崎喜脩、渡部隆義、永瀬浩喜、高取敦志
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20K07710
[Presentation] 変異ALK遺伝子依存性神経芽腫におけるアルキル化PIポリアミド化合物の抗腫瘍効果2022
- Author(s)
  太田陽子, 永瀬浩喜, 高取敦志
- Organizer
  第59回日本小児外科学会学術集会
- Data Source
  KAKENHI-PROJECT-22K07245
[Presentation] Development of Novel Therapies Targeting the Amplified MYCN Gene in Neuroblastoma2022
- Author(s)
  頼　笑疑、養田裕行、篠崎喜脩、渡部隆義、永瀬浩喜、高取敦志
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-19K07767
[Presentation] Site-selective DNA alkylation within the F1174L-muated ALK gene shows anti-tumor activity in neuroblastoma2022
- Author(s)
  高取敦志, 太田陽子, 養田裕行, 渡部隆義, 永瀬浩喜
- Organizer
  第81回日本癌学会学術集会
- Data Source
  KAKENHI-PROJECT-22K07245
[Presentation] Targeting the mutant PIK3CA gene by DNA-alkylating pyrrole imidazole polyamide in cervical cancer2021
- Author(s)
  高取敦志、Sakthisri Krishnamurthy、養田裕行、井上貴博、平岡桐子、Jason Lin、渡部隆義、越川信子、永瀬浩喜
- Organizer
  第80回日本癌学会学術集会
- Data Source
  KAKENHI-PROJECT-19K07767
[Presentation] 神経芽腫のALK遺伝子変異を標的としたアルキル化ピロール・イミダゾールポリアミド化合物の抗腫瘍効果2021
- Author(s)
  太田陽子、養田裕行、井上貴博、渡部隆義、篠崎喜脩、永瀬浩喜、高取敦志
- Organizer
  第63回日本小児血液・がん学会学術集会
- Data Source
  KAKENHI-PROJECT-19K07767
[Presentation] 神経芽腫のALK遺伝子異常を標的とした新規治療薬開発2020
- Author(s)
  高取敦志、太田陽子、養田裕行、井上貴博、渡部隆義、篠崎喜脩、永瀬浩喜
- Organizer
  第67回日本実験動物学会総会
- Data Source
  KAKENHI-PROJECT-19K07767
[Presentation] 神経芽腫のMYCN遺伝子特異的DNA傷害とPARP阻害剤の併用効果2020
- Author(s)
  高取敦志、養田裕行、渡部隆義、篠崎喜脩、永瀬浩喜
- Organizer
  第61回日本小児血液・がん学会学術集会
- Data Source
  KAKENHI-PROJECT-19K07767
[Presentation] Targeting the amplified ALK gene by using a pyrrole-imidazole polyamide alkylator against neuroblastoma2020
- Author(s)
  高取敦志、永瀬浩喜
- Organizer
  第24回日本がん分子標的治療学会
- Data Source
  KAKENHI-PROJECT-19K07767
[Presentation] Development of a novel therapeutic strategy targeting amplified genomic region of oncogenes in solid cancers2020
- Author(s)
  高取敦志、養田裕行、渡部隆義、篠崎喜脩、永瀬浩喜、丸喜明、筆宝義隆
- Organizer
  第79回日本癌学会学術集会
- Data Source
  KAKENHI-PROJECT-19K07767
[Presentation] Evaluation of alkylating pyrrole-imidazole polyamides for novel therapy of neuroblastoma with ALK gene aberration2020
- Author(s)
  太田陽子、養田裕行、井上貴博、渡部隆義、篠崎喜脩、永瀬浩喜、高取敦志
- Organizer
  第79回日本癌学会学術集会
- Data Source
  KAKENHI-PROJECT-19K07767
[Presentation] Investigation of antitumor effect of PIP-CBI derivatives containing amino group2020
- Author(s)
  渡部隆義、高取敦志、篠崎喜脩、木田裕貴、越川信子、永瀬浩喜
- Organizer
  第79回日本癌学会学術集会
- Data Source
  KAKENHI-PROJECT-19K07767
[Presentation] 神経芽腫のMYCN遺伝子増幅領域を標的とした革新的治療薬の開発2020
- Author(s)
  高取敦志
- Organizer
  第151回小児血液腫瘍免疫懇話会
- Invited
- Data Source
  KAKENHI-PROJECT-19K07767
[Presentation] 神経芽腫の増幅MYCN遺伝子を標的としたPIポリアミドDNAアルキル化剤の抗腫瘍活性と安全性2019
- Author(s)
  高取敦志、養田裕行、井上貴博、渡部隆義、越川信子、永瀬浩喜
- Organizer
  第32回モロシヌス研究会
- Data Source
  KAKENHI-PROJECT-19K07767
[Presentation] PARP inhibitors enhance cell death induced by sequence-specific alkylation of the amplified MYCN gene in neuroblastoma cells2019
- Author(s)
  高取敦志、永瀬浩喜
- Organizer
  第23回日本がん分子標的治療学会
- Data Source
  KAKENHI-PROJECT-19K07767
[Presentation] アルキル化ピロール・イミダゾールポリアミドを用いた膵癌における薬剤感受性関連遺伝子の探索2019
- Author(s)
  辻本彰子、養田裕行、Jason Lin 、松尾仁以奈、渡部隆義、篠崎喜脩、永瀬浩喜、高取敦志
- Organizer
  第78回日本癌学会学術集会
- Data Source
  KAKENHI-PROJECT-17K07259
[Presentation] ヒトテロメラーゼ逆転写酵素（hTERT）を標的としたアルキル化PDCによる治療戦略の構築2019
- Author(s)
  渡部隆義、高取敦史、養田裕行、越川信子、Lin Jason、篠崎喜脩、永瀬浩喜
- Organizer
  第28回日本癌病態治療研究会
- Data Source
  KAKENHI-PROJECT-17K07259
[Presentation] hTERT 遺伝子を標的とした PIP 化合物と抗癌活性の向上を指向した誘導体の開発2019
- Author(s)
  渡部隆義、高取敦志、養田裕行、越川信子、篠崎喜脩、永瀬浩喜
- Organizer
  第78回日本癌学会学術集会
- Data Source
  KAKENHI-PROJECT-17K07259
[Presentation] Novel therapeutic strategy for neuroblastoma by a combination of PARP inhibition and site-specific DNA damage within the amplified region of the MYCN gene2019
- Author(s)
  高取敦志、養田裕行、渡部隆義、篠崎喜脩、永瀬浩喜
- Organizer
  第78回日本癌学会学術集会
- Data Source
  KAKENHI-PROJECT-19K07767
[Presentation] 膵癌におけるアルキル化ピロール・イミダゾールポリアミドの薬理効果と感受性関連遺伝子の探索2018
- Author(s)
  辻本彰子、高取敦志、松尾仁以奈、K.Sakthisri、L.Jason、篠崎喜脩、渡部隆義、永瀬浩喜
- Organizer
  第27回日本癌病態治療研究会
- Data Source
  KAKENHI-PROJECT-17K07259
[Presentation] PIポリアミドDNAアルキル化剤によるEwing肉腫のEWS-FLI1融合遺伝子標的治療薬開発2018
- Author(s)
  太田陽子、養田裕行、渡部隆義、平岡桐子、クリシュナムーティ　サクティシリ、篠崎喜脩、岩田慎太郎、田中美和、中村卓郎、永瀬浩喜、高取敦志
- Organizer
  第60回日本小児血液・がん学会学術集会
- Data Source
  KAKENHI-PROJECT-16K07188
[Presentation] Targeting the amplified MYCN gene using PI polyamide alkylating agent in neuroblastoma2017
- Author(s)
  A Takatori, H Yoda, T Inoue, T Watanabe, Y Shinozaki, N Koshikawa, S Wakana, H Nagase
- Organizer
  3rd Asia-Pacific International Symposium of Neuroblastoma
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07188
[Presentation] Development of novel therapeutic agents targeting amplified genomic region of oncogenes2017
- Author(s)
  Atsushi Takatori, Shintaro Iwata, Kiriko Hiraoka, Sakthisri Krishnamurthy, Hiroyuki Yoda, Takayoshi Watanabe, Yoshinao Shinozaki, Miwa Tanaka, Takuro Nakamura, Hiroki Nagase
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16K07188
[Presentation] 膵腺管癌におけるKRAS 変異を標的にしたKR122017
- Author(s)
  松尾仁以奈、井上貴博、養田祐行、高取敦志、篠崎喜脩、渡部隆義、越川信子、ジェイソンリン、永瀬浩喜
- Organizer
  第76回日本癌学会学術総会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07259
[Presentation] Targeting the EWS-FLI1 fusion gene by pyrrole-imidazole polyamide alkylator in Ewing sarcoma cells2016
- Author(s)
  Atsushi Takatori, Shintaro Iwata, Kiriko Hiraoka, Sakthisri Krishnamurthy, Hiroyuki Yoda, Takayoshi Watanabe, Yoshinao Shinozaki, Miwa Tanaka, Takuro Nakamura, Hiroki Nagase
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-16K07188
[Presentation] Novel candidate compounds identified by in silico screening activate TrkB and attenuate depressant-like behavior in mice2015
- Author(s)
  Mayu Fukuda, Atsushi Takatori, Yohko Nakamura, Akiko Suganami, Tyuji Hoshino, Yutaka Tamura and Akira Nakagawara
- Organizer
  第58回日本神経化学会
- Place of Presentation
  埼玉県さいたま市
- Year and Date
  2015-09-11
- Data Source
  KAKENHI-PROJECT-25830092
[Presentation] in silico スクリーニングで同定された低分子化合物はTrkBの活性化を誘導し、マウスのうつ病様症状を低下させる2015
- Author(s)
  福田真佑、高取敦志、中村洋子、菅波晃子、星野忠次、田村裕、中川原章、田川雅敏
- Organizer
  第３８回分子生物学会年会第88回日本生化学会大会合同大会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25830092
[Presentation] NLRR2 is involved in neuronal survival and differentiation through JNK pathway in neuroblastoma2015
- Author(s)
  Afzal Sheikh,Atsushi Takatori,Md.Shamim Hossain,Md.Kamrul Hasan,Toshinori Ozaki,Hiroki Nagase,Masatoshi Tagawa,Akira Nakagawara
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  愛知県名古屋市
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-25830092
[Presentation] NLRR1 is a cis-acting modulator of growth-promoting receptor and a potential target for therapy of neuroblastoma2013
- Author(s)
  高取敦志、中川原章
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  横浜
- Invited
- Data Source
  KAKENHI-PROJECT-25830092
[Presentation] NLRR1の機能ドメイン同定と進行神経芽腫の治療法開発への応用2013
- Author(s)
  高取　敦志、中村　洋子、中川原　章
- Organizer
  第55回日本小児血液・がん学会学術集会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-25830092
[Presentation] NLRR1によるEGFおよびIGFシグナルの制御メカニズムと新規分子標的治療法の可能性2012
- Author(s)
  高取　敦志　等
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  ロイトン札幌（北海道）
- Data Source
  KAKENHI-PROJECT-22791016
[Presentation] NLRR1によるEGFおよびIGFシグナルの制御メカニズムと新規分子標的治療法の可能性2012
- Author(s)
  高取敦志他
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  札幌
- Year and Date
  2012-09-21
- Data Source
  KAKENHI-PROJECT-22791016
[Presentation] NLRR1, a direct target of MYCN, regulates cell growth both in vitro and in vivo and can be a therapeutic target against high-risk neuroblastoma2012
- Author(s)
  Takatori, A.
- Organizer
  STOP2012
- Place of Presentation
  イギリス・ロンドン
- Year and Date
  2012-10-07
- Data Source
  KAKENHI-PROJECT-22791016
[Presentation] NLRR1, a direct target of MYCN, regulates cell growth both in vitro and in vivo and can be a therapeutic target against high-risk neuroblastoma2012
- Author(s)
  Takatori, A.
- Organizer
  Advanced Neuroblastoma Research (ANR) 2012
- Place of Presentation
  カナダ・トロント
- Year and Date
  2012-06-19
- Data Source
  KAKENHI-PROJECT-22791016
[Presentation] 増殖シグナルを制御するNLRR1を標的とした進行神経芽腫に対する治療用単クローン抗体の開発2012
- Author(s)
  高取　敦志　等
- Organizer
  第54回日本小児血液・がん学会学術集会
- Place of Presentation
  パシフィコ横浜（神奈川県）
- Data Source
  KAKENHI-PROJECT-22791016
[Presentation] NLRR1, a direct target of MYCN, regulates cell growth both in vitro and in vivo and can be a therapeutic target against high-risk neuroblastoma2012
- Author(s)
  Atsushi Takatori　等
- Organizer
  SIOP2012
- Place of Presentation
  バービカン・センター（イギリス・ロンドン）
- Invited
- Data Source
  KAKENHI-PROJECT-22791016
[Presentation] NLRR1, a direct target of MYCN, regulates cell growth both in vitro and in vivo and can be a therapeutic target against high-risk neuroblastoma2012
- Author(s)
  Atsushi Takatori　等
- Organizer
  Advanced Neuroblastoma Research (ANR) 2012
- Place of Presentation
  フェアモント・ロイヤル・ヨーク（カナダ・トロント）
- Data Source
  KAKENHI-PROJECT-22791016
[Presentation] NLRR1, apotential molecular target of neuroblastoma, has functional significance in cell growth and mouse development2011
- Author(s)
  高取敦志他
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2011-10-05
- Data Source
  KAKENHI-PROJECT-22791016
[Presentation] NLRR1, a potential molecular target of neuroblastoma, has functional significance in cell growth and mouse development2011
- Author(s)
  高取敦志, 等
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場(名古屋)
- Year and Date
  2011-10-05
- Data Source
  KAKENHI-PROJECT-22791016
[Presentation] NLRR1, a direct target gene of MYCN, modulates aggressive growth of neuroblastoma by selectively enhancing EGF and IGF signals through the components of lipid rafts2010
- Author(s)
  Takatori, A.
- Organizer
  ANR2010
- Place of Presentation
  スウェーデン・ストックホルム
- Year and Date
  2010-06-22
- Data Source
  KAKENHI-PROJECT-22791016
[Presentation] NLRR1 enhances EGF and IGF signals through the components of lipid rafts and contributes to cell growth2010
- Author(s)
  高取、Hossain, 他4名
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  大阪国際会議場
- Year and Date
  2010-09-23
- Data Source
  KAKENHI-PROJECT-22791016
[Presentation] NLRR family proteins play distinct roles in deciding cell fate and affect the clinical outcome in neuroblastomas2010
- Author(s)
  高取、Hossain, 他7名
- Organizer
  第101回アメリカ癌学会総会
- Place of Presentation
  アメリカ・デンバー
- Year and Date
  2010-04-21
- Data Source
  KAKENHI-PROJECT-22791016
[Presentation] 新規オーファン受容体NLRR1はEGFおよびIGFの増殖シグナルを増強する2010
- Author(s)
  高取、Hossain, 他4名
- Organizer
  第19回日本癌病態治療研究会
- Place of Presentation
  東京ステーションコンファレンス
- Year and Date
  2010-06-30
- Data Source
  KAKENHI-PROJECT-22791016
[Presentation] A novel neuronal receptor, NLRR3, is negatively regulated by MYCN and induces differentiation of neuroblastoma2008
- Author(s)
  Jesmin Akter、Shamim Hossain、尾崎俊文、高取敦志、末永雄介、中村洋子、中川原章
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2008-10-28
- Data Source
  KAKENHI-PROJECT-19890276
[Presentation] MYCN directly transactivates NLRR1 gene for promoting cell proliferation in neuroblastoma2008
- Author(s)
  Hossain, 高取, 他6名
- Organizer
  第24回日本小児がん学会学術集会
- Place of Presentation
  幕張メッセ国際会議場
- Year and Date
  2008-11-15
- Data Source
  KAKENHI-PROJECT-19890276
[Presentation] NLRR3 is negatively targeted by MYCN and induced during differentiation of neuroblastoma2008
- Author(s)
  Jesmin Akter、Shamim Hossain、尾崎俊文、高取敦志、末永雄介、中村洋子、中川温子、中川原章
- Organizer
  第24回日本小児がん学会学術集会
- Place of Presentation
  幕張メッセ国際会議場
- Year and Date
  2008-11-15
- Data Source
  KAKENHI-PROJECT-19890276
[Presentation] NLRR1 enhances cell growth signals induced by EGF and IGF in cancer cells in cluding neuroblastoma2008
- Author(s)
  高取, Hossain, Akter, 中川原
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2008-10-28
- Data Source
  KAKENHI-PROJECT-19890276
[Presentation] NLRR1 enhances cell growth signals induced by EGF and IGF in cancer cells including neuroblastoma2008
- Author(s)
  高取敦志、Shamim Hossain、Jesmin Akter、中川原章
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2008-10-28
- Data Source
  KAKENHI-PROJECT-19890276
[Presentation] Neuronal leucine rich repeat (NLRR1) is a target gene of MYCN and regulates aggressiveness of neuroblastoma2008
- Author(s)
  Shamim Hossain、高取敦志、Jesmin Akter、王弘、大平美紀、尾崎俊文、中川原章
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2008-10-28
- Data Source
  KAKENHI-PROJECT-19890276
[Presentation] MYCN directly transactivates NLRR1 gene for promoting cell proliferation in Neuroblastoma2008
- Author(s)
  Shamim Hossain、高取敦志、Jesmin Akter、王弘、大平美紀、尾崎俊文、中川温子、中川原章
- Organizer
  第24回日本小児がん学会学術集会
- Place of Presentation
  幕張メッセ国際会議場
- Year and Date
  2008-11-15
- Data Source
  KAKENHI-PROJECT-19890276
[Presentation] Neuronal Leucine Rich Repeat Protein1 (NLRR1) inhibits cell growth via suppressing NGF/TrkA signals in neuroblastoma cells
- Author(s)
  Mayu Fukuda, Atsushi Takatori, Yohko Nakamura, Akira Nakagawara
- Organizer
  第56回日本小児血液・がん学会学術集会
- Place of Presentation
  岡山
- Year and Date
  2014-11-28 – 2014-11-30
- Data Source
  KAKENHI-PROJECT-25830092
[Presentation] Neuronal Leucine Rich Repeat Protein1 (NLRR1) proteins repress NGF-dependent cell growth in neuroblastoma cells
- Author(s)
  Mayu Fukuda, Atsushi Takatori, Yohko Nakamura, Akira Nakagawara
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-25830092
[Presentation] Anti-NLRR1 monoclonal antibody inhibits growth of neuroblastoma xenograft in mice
- Author(s)
  Atsushi Takatori, Yohko Nakamura and Akira Nakagawara
- Organizer
  Advanced Neuroblastoma Research (ANR) 2014
- Place of Presentation
  ドイツ・ケルン
- Year and Date
  2014-05-13 – 2014-05-16
- Data Source
  KAKENHI-PROJECT-25830092
[Presentation] Additional receptor tyrosine kinases compensate survival signals in ALK inhibitor-treated neuroblastoma cells
- Author(s)
  Shunpei Satoh, Atsushi Takatori, Miki Ohira, Yohko Nakamura, Akira Nakagawara
- Organizer
  Advanced Neuroblastoma Research (ANR) 2014
- Place of Presentation
  ドイツ・ケルン
- Year and Date
  2014-05-13 – 2014-05-16
- Data Source
  KAKENHI-PROJECT-25830092
[Presentation] γ-secretase mediated intramembrane proteolysis of NLRR3 leads to the liberation of its intracellular domain and its role in the NB differentiation
- Author(s)
  Jesmin Akter, Atsushi Takatori, MD. Sazzadul Islam, Akira Nakagawara
- Organizer
  Advanced Neuroblastoma Research (ANR) 2014
- Place of Presentation
  ドイツ・ケルン
- Year and Date
  2014-05-13 – 2014-05-16
- Data Source
  KAKENHI-PROJECT-25830092

1. Watanabe Takayoshi (60526060)

# of Collaborated Projects: 5 results

# of Collaborated Products: 27 results
2. NAKAMURA Yohko (60260254)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
3. 越川信子 (90260249)

# of Collaborated Projects: 3 results

# of Collaborated Products: 4 results
4. NAKAGAWARA Akira (50117181)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
5. SUENAGA Yusuke (80581793)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. 丸喜明 (30742754)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
7. OOHIRA Miki (20311384)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 岩田慎太郎 (90549685)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
9. 篠崎喜脩 (00766553)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
10. 竹永啓三 (80260256)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 市川美紀

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
12. 早田浩明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 下里修

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

TAKATORI ATSUSHI 高取 敦志

ATSUSHI Takatori 高取 敦志

Research Projects

Research Products

Co-Researchers

難治性がんの発生原因となる異常なゲノムの増幅領域および反復配列の標的化Principal Investigator

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Analysis of the role of mtDNA mutations in invasion and metastasis using mitochondrial intercellular transfer

Principal Investigator

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Development of amplified gene-specific alkylator as a novel therapeutic agent using patient-derived organoids from solid tumorsPrincipal Investigator

Principal Investigator

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Review Section

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Exploring the potential of PIP-CBI derivatives with amino groups as anticancer agents for drug discovery

Principal Investigator

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Review Section

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Development of amplified gene-selective alkylator as a novel cancer therapeutic agentPrincipal Investigator

Principal Investigator

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Review Section

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Development of therapeutic strategy using molecules of targeting genomic mutation for pancreatic ductal carcinoma

Principal Investigator

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Targeting the fusion genes using pyrrole-imidazole polyamides in Ewing and synovial sarcoma cellsPrincipal Investigator

Principal Investigator

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Research Institution

Molecular mechanism by which NLRR1, a therapeutic target in neuroblastoma, selectively enhances growth signalsPrincipal Investigator

Principal Investigator

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Research Category

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Research Institution

Generation of the MYCN/NCYM mouse model and the drug discovery for human neuroblastoma

Principal Investigator

Project Period (FY)

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Research Institution

Mechanism of NLRR1-regulated signaling pathway and establishment of a novel targeted therapyPrincipal Investigator

Principal Investigator

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Functional analysis of NLRR family genes in neuroblastoma

Principal Investigator

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Analysis on the function of NLRR family protein in development and tumorigenesisPrincipal Investigator

Principal Investigator

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Research Institution

[Journal Article] Use of DNA‐alkylating pyrrole‐imidazole polyamides for anti‐cancer drug sensitivity screening in pancreatic ductal adenocarcinoma2022

Author(s)

Journal Title

TAKATORI ATSUSHI 高取敦志

ATSUSHI Takatori 高取敦志

[Journal Article] NCYM, a Cis-antisense gene of MYCN,　encodes a de novo evolved protein that inhibits GSK3β resulting in the　stabilization of MYCN in human neuroblastomas.2014

[Journal Article] ALK is a MYCN target　gene and regulates cell migration and invasion in neuroblastoma.2013