SAKAI Hiroki 酒井大樹

Researcher Number	40464367
Other IDs
Affiliation (based on the past Project Information) *help	2023: 山口大学, 大学院医学系研究科, 助教 2022: 山口大学, 大学院医学系研究科, 講師(特命) 2017 – 2021: 山口大学, 大学院医学系研究科, 助教 2013 – 2016: 山口大学, 医学(系)研究科(研究院), 助教 2015: 山口大学, 大学院医学系研究科, 助教
Review Section/Research Field	Principal Investigator Basic Section 48030:Pharmacology-related / General pharmacology / Applied pharmacology Except Principal Investigator General pharmacology / Basic Section 48030:Pharmacology-related
Keywords	Principal Investigator 核酸アプタマー / 細胞膜透過性ペプチド / 心不全治療薬 / アプタマー / ホスホランバン / 質量分析 / 創傷治癒促進薬 / ペプチド / アンギオテンシン変換酵素 / アンギオテンシンII … More / 神経栄養因子 / 成長因子 / 表皮細胞 / 創傷治癒 … More Except Principal Investigator 心筋細胞 / ペプチド / ホスホランバン / 細胞内導入 / 液液相分離 / パラスペックル / 液液相分離体 / PDZRN3 / 細胞分化 / 環状ペプチド / ペプチド医薬 / 心不全 / 超微細構造解析 / ナノディスク / SERCA / 心筋小胞体 / カルシウム輸送 / 心不全治療薬 / 皮膚創傷治癒 / 免疫抑制作用 / 蛍光標識架橋薬 / 血管誘導作用 / 創傷治癒促進作用 / 天然環状ペプチド / 薬物送達 / 核酸アプタマー / 角膜 / アンギオテンシンI変換酵素 / 皮膚 / アンギオテンシン / インスリン様成長因子 / 細胞遊走 / 創傷治癒 Less

The role of PDZRN3 in the regulation of cardiomyocyte differentiation
- Principal Investigator
  
  Honda Takeshi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48030:Pharmacology-related
- Research Institution
  Kurume University
  Yamaguchi University
Mechanism of promoting wound healing by the coordinated action of growth factors and neurotrophic factorsPrincipal Investigator
- Principal Investigator
  
  Sakai Hiroki
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48030:Pharmacology-related
- Research Institution
  Yamaguchi University
Development of Novel Cyclic Peptide Drugs Targeting Phospholamban for the Treatment of Heart Failure
- Principal Investigator
  
  Honda Takeshi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48030:Pharmacology-related
- Research Institution
  Yamaguchi University
Ultrastructural analysis of calcium transport system of cardiac sarcoplasmic reticulum for drug development
- Principal Investigator
  
  INUI Makoto
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General pharmacology
- Research Institution
  Yamaguchi University
Elucidation of the molecular mechanisms by a cyclic peptide, SEK-1005 promotes skin wound healing
- Principal Investigator
  
  INUI Makoto
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  General pharmacology
- Research Institution
  Yamaguchi University
Development of cardiomyocyte-specific intracellular drug-delivery system for therapy of cardiac diseases
- Principal Investigator
  
  HONDA Takeshi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Yamaguchi University
Development of phospholamban aptamer as a treatment of heart failure for clinical applicationPrincipal Investigator
- Principal Investigator
  
  SAKAI Hiroki
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General pharmacology
- Research Institution
  Yamaguchi University
Analysis of IGF-1 receptor-independent signaling from IGF-1 and its application for drug development
- Principal Investigator
  
  INUI Makoto
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  General pharmacology
- Research Institution
  Yamaguchi University
Development of phospholamban aptamer as a novel therapeutic tool for treatment of heart failurePrincipal Investigator
- Principal Investigator
  
  SAKAI Hiroki
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Applied pharmacology
- Research Institution
  Yamaguchi University

All 2022 2021 2018 2017 2016 2015 2014 Other

All Journal Article Presentation

[Journal Article] Assessment of binding potencies of polychlorinated biphenyls and polybrominated diphenyl ethers with Baikal seal and mouse constitutive androstane receptors: Comparisons across species and congeners.2022
- Author(s)
  Dau PT, Ishibashi H, Tuyen LH, Sakai H, Hirano M, Kim EY, Iwata H.
- Journal Title
  
  Sci Total Environ
  
  Volume: 806 Pages: 150631-150631
- DOI
  10.1016/j.scitotenv.2021.150631
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07319, KAKENHI-PROJECT-19H04286, KAKENHI-PROJECT-19H01150
[Journal Article] Dantrolene, a stabilizer of the ryanodine receptor, prevents collagen-induced arthritis.2022
- Author(s)
  58)Nawata T, Sakai H, Honda T, Otsuka M, Fujita H, Uchinoumi H, Kobayashi S, Yamamoto T, Asagiri M, Yano M.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 624 Pages: 141-145
- DOI
  10.1016/j.bbrc.2022.07.111
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06803, KAKENHI-PROJECT-21K08054, KAKENHI-PROJECT-21K08128, KAKENHI-PROJECT-20H03677
[Journal Article] Calcium/calmodulin-dependent regulation of Rac GTPases and Akt in histamine-induced chemotaxis of mast cells2021
- Author(s)
  Honda Takeshi、Nishio Yusuke、Sakai Hiroki、Asagiri Masataka、Yoshimura Kiyoshi、Inui Makoto、Kuramasu Atsuo
- Journal Title
  
  Cellular Signalling
  
  Volume: 83 Pages: 109973-109973
- DOI
  10.1016/j.cellsig.2021.109973
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07319, KAKENHI-PROJECT-20H03749, KAKENHI-PROJECT-18K06892, KAKENHI-PROJECT-19K07320
[Journal Article] Long-term Functioning of Allogeneic Islets in Subcutaneous Tissue Pretreated with a Novel Cyclic Peptide without Immunosuppressive Medication2018
- Author(s)
  Kuwabara Rei、Hamaguchi Masahide、Fukuda Takuya、Sakai Hiroki、Inui Makoto、Sakaguchi Shimon、Iwata Hiroo
- Journal Title
  
  Transplantation
  
  Volume: 102 Issue: 3 Pages: 417-425
- DOI
  10.1097/tp.0000000000001923
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K15203, KAKENHI-PROJECT-17H01579, KAKENHI-PROJECT-17H04033, KAKENHI-PROJECT-16J06573, KAKENHI-PROJECT-16H06295
[Journal Article] A pyridone derivative activates SERCA2a by attenuating the inhibitory effect of phospholamban2017
- Author(s)
  Kaneko Manami、Yamamoto Hisato、Sakai Hiroki、Kamada Yusuke、Tanaka Toshiki、Fujiwara Shuji、Yamamoto Syunsuke、Takahagi Hiroki、Igawa Hideyuki、Kasai Shizuo、Noda Masakuni、Inui Makoto、Nishimoto Tomoyuki
- Journal Title
  
  European Journal of Pharmacology
  
  Volume: 814 Pages: 1-8
- DOI
  10.1016/j.ejphar.2017.07.035
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K15203, KAKENHI-PROJECT-17H04033, KAKENHI-PROJECT-15K08235
[Journal Article] Signaling mechanism underlying the promotion of keratinocyte migration by angiotensin II2015
- Author(s)
  Hiroki Sakai, Kenji Matsuura, Yoshie Tanaka, Takeshi Honda, Teruo Nishida, Makoto Inui
- Journal Title
  
  Molecular Pharmacology
  
  Volume: 87 Issue: 2 Pages: 277-285
- DOI
  10.1124/mol.114.096461
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25870470, KAKENHI-PROJECT-25670128, KAKENHI-PROJECT-25293062
[Journal Article] A cell-penetrating phospholamban-specific RNA aptamer enhances Ca2+ transients and contractile function in cardiomyocytes.2014
- Author(s)
  Sakai, H., Ikeda, Y., Honda, T., Tanaka, Y., Shiraishi, K., and Inui, M.
- Journal Title
  
  J. Mol. Cell. Cardiol.
  
  Volume: 76 Pages: 177-185
- DOI
  10.1016/j.yjmcc.2014.09.006
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25293062, KAKENHI-PROJECT-25670128, KAKENHI-PROJECT-25870470
[Presentation] キョウチクトウ科植物由来抽出物による炎症促進性型M1マクロファージ活性化と破骨細胞分化の抑制2022
- Author(s)
  石田千賀、鈴木美恋、瀬戸哲也、大塚まりな、酒井大樹、竹入雅敏、常陰幸乃、新井啓子、本田健、木村吉秀、朝霧成挙
- Organizer
  第95回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-19K07319
[Presentation] 炎症性破骨細胞形成に対するスペルミジンの抑制効果2022
- Author(s)
  田中誠也、岡本明日香、椿帆乃香、瀬戸哲也、酒井大樹、本田健、朝霧成挙
- Organizer
  第95回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-19K07319
[Presentation] 合成レチノイド抗腫瘍薬ベキサロテンは炎症性破骨細胞の分化を阻害する2022
- Author(s)
  竹上陽菜、仲村日和、竹田彩乃、松尾真結、酒井大樹、本田健、朝霧成挙
- Organizer
  第95回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-19K07319
[Presentation] Inhibitory effect of spermidine on differentiation of inflammatory osteoclasts2022
- Author(s)
  Seiya Tanaka, Asuka Okamoto, Honoka Tsubaki, Tetsuya Seto, Hiroki Sakai, Takeshi Honda, Masataka Asagiri
- Organizer
  第95回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-21K06803
[Presentation] Synthetic retinoid bexarotene inhibits differentiation of inflammatory osteoclasts.2022
- Author(s)
  Hina Takegami, Hiyori Nakamura, Ayano Takeda, Mayu Matsuo, Hiroki Sakai, Takeshi Honda, Masataka Asagiri
- Organizer
  第95回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-21K06803
[Presentation] A novel intracellular drug-delivery system specific for cardiomyocytes using RNA aptamer2021
- Author(s)
  Takeshi Honda, Hiroki Sakai, Makoto Inui
- Organizer
  第94回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-18K06892
[Presentation] Enhancement of myogenic differentiation by MMP inhibition and attenuation of the enhancement effect in senescent cells2021
- Author(s)
  Hiroki Sakai, Takeshi Honda, Kouetsu Ogasawara, Masataka Asagiri
- Organizer
  第94回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-19K07319
[Presentation] A novel intracellular drug-delivery system specific for cardiomyocytes using RNA aptamer2021
- Author(s)
  Takeshi Honda, Hiroki Sakai, Inui Makoto
- Organizer
  第94回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-19K07319
[Presentation] IGF-1 promotes epithelial wound healing independently of the IGF-1 receptor via angiotensin II signaling.2016
- Author(s)
  酒井大樹、松浦健二、本田健、西田輝夫、乾　誠
- Organizer
  第８９回日本薬理学会
- Place of Presentation
  横浜市（パシフィコ横浜）
- Year and Date
  2016-03-09
- Data Source
  KAKENHI-PROJECT-25670128
[Presentation] IGF-1 promotes epithelial wound healing independently of the IGF-1 receptor via angiotensin II signaling2016
- Author(s)
  酒井大樹、松浦健二、本田健、西田輝夫、乾誠
- Organizer
  第89回日本薬理学会年会
- Place of Presentation
  横浜市（パシフィコ横浜）
- Year and Date
  2016-03-09
- Data Source
  KAKENHI-PROJECT-15K18989
[Presentation] 皮膚創傷治癒過程におけるIGF-1と知覚神経由来のサブスタンスPとの協調作用のメカニズム2015
- Author(s)
  酒井大樹、松浦健二、本田健、権藤俊一、山本久斗、西田輝夫、乾誠
- Organizer
  第68回日本薬理学会西南部会
- Place of Presentation
  下関市（海峡メッセ下関）
- Year and Date
  2015-11-21
- Data Source
  KAKENHI-PROJECT-15K18989
[Presentation] 皮膚創傷治癒過程におけるIGH-1と知覚神経由来のサブスタンスPとの協調作用のメカニズム2015
- Author(s)
  酒井大樹、松浦健二、本田健、西田輝夫、乾　誠
- Organizer
  第６８回日本薬理学会西南部会
- Place of Presentation
  下関市（海峡メッセ下関）
- Year and Date
  2015-11-21
- Data Source
  KAKENHI-PROJECT-25670128
[Presentation] ホスホランバンアプタマーによる心筋収縮能およびCa2+トランジェントの増強作用2014
- Author(s)
  酒井大樹、池田安宏、本田健、田中貴絵、白石宏造、乾誠
- Organizer
  第67回日本薬理学会西南部会
- Place of Presentation
  産業医科大学（福岡県・北九州市）
- Year and Date
  2014-11-23
- Data Source
  KAKENHI-PROJECT-25870470
[Presentation] Promotion of endothelial cell migration and tube formation by SEK-10052014
- Author(s)
  酒井大樹、中島京、岩田博夫、乾誠
- Organizer
  第87回日本薬理学会年会
- Place of Presentation
  仙台国際センター（宮城県）
- Data Source
  KAKENHI-PROJECT-25870470
[Presentation] Enhancement of Ca2+ transient and contractile function of cardiomyocytes by phospholamban specific RNA aptamer
- Author(s)
  酒井大樹、池田安宏、本田健、田中貴絵、白石宏造、乾誠
- Organizer
  第88回日本薬理学会年会
- Place of Presentation
  名古屋国際会議場（愛知県・名古屋市）
- Year and Date
  2015-03-18 – 2015-03-20
- Data Source
  KAKENHI-PROJECT-25870470
[Presentation] SEK-1005による血管内皮細胞の遊走及び管腔形成促進効果
- Author(s)
  酒井大樹、中島京、岩田博夫、乾誠
- Organizer
  第23回日本循環薬理学会
- Place of Presentation
  福岡大学メディカルホール（福岡県）
- Data Source
  KAKENHI-PROJECT-25870470
[Presentation] Promotion of vascular endothelial cell migration and tube formation by SEK-1005.
- Author(s)
  酒井大樹、中島京、岩田博夫、乾　誠
- Organizer
  日本薬理学会
- Place of Presentation
  仙台国際センター（仙台市）
- Data Source
  KAKENHI-PROJECT-25670128
[Presentation] SEK-1005による血管内皮細胞の遊走及び管腔形成促進効果
- Author(s)
  酒井大樹、中島京、岩田博夫、乾　誠
- Organizer
  日本循環薬理学会
- Place of Presentation
  福岡大学（福岡市）
- Data Source
  KAKENHI-PROJECT-25670128

1. INUI Makoto (70223237)

# of Collaborated Projects: 6 results

# of Collaborated Products: 10 results
2. HONDA Takeshi (30457311)

# of Collaborated Projects: 5 results

# of Collaborated Products: 5 results
3. 倉増敦朗 (90302091)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 朝霧成挙 (20372435)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results

SAKAI Hiroki 酒井 大樹

Research Projects

Research Products

Co-Researchers

The role of PDZRN3 in the regulation of cardiomyocyte differentiation

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mechanism of promoting wound healing by the coordinated action of growth factors and neurotrophic factorsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of Novel Cyclic Peptide Drugs Targeting Phospholamban for the Treatment of Heart Failure

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Ultrastructural analysis of calcium transport system of cardiac sarcoplasmic reticulum for drug development

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of the molecular mechanisms by a cyclic peptide, SEK-1005 promotes skin wound healing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of cardiomyocyte-specific intracellular drug-delivery system for therapy of cardiac diseases

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of phospholamban aptamer as a treatment of heart failure for clinical applicationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of IGF-1 receptor-independent signaling from IGF-1 and its application for drug development

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of phospholamban aptamer as a novel therapeutic tool for treatment of heart failurePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Assessment of binding potencies of polychlorinated biphenyls and polybrominated diphenyl ethers with Baikal seal and mouse constitutive androstane receptors: Comparisons across species and congeners.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Dantrolene, a stabilizer of the ryanodine receptor, prevents collagen-induced arthritis.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Calcium/calmodulin-dependent regulation of Rac GTPases and Akt in histamine-induced chemotaxis of mast cells2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Long-term Functioning of Allogeneic Islets in Subcutaneous Tissue Pretreated with a Novel Cyclic Peptide without Immunosuppressive Medication2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A pyridone derivative activates SERCA2a by attenuating the inhibitory effect of phospholamban2017

Author(s)

SAKAI Hiroki 酒井大樹