OHKUNI Tsuyoshi 大國毅

… Alternative Names

大國毅オオクニツヨシ

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Researcher Number	40464490
Affiliation (Current)	2025: 札幌医科大学, 医学部, 講師
Affiliation (based on the past Project Information) *help	2024: 札幌医科大学, 医学部, 講師 2018 – 2020: 札幌医科大学, 医学部, 講師 2011 – 2017: 札幌医科大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Otorhinolaryngology / Basic Section 56050:Otorhinolaryngology-related Except Principal Investigator Otorhinolaryngology
Keywords	Principal Investigator ヒト鼻粘膜上皮 / タイト結合 / 自然免疫 / RSウイルス / 上皮 / IgG4 / KLF11 / CYP / ギャップ結合 / h TERT … More / ヒト鼻粘膜上皮細胞 / p63 / HMBG1 / 上気道慢性炎症 / 上皮バリア / HDAC / claudin / claudins / バリア機能 / PAR3 / ASPP2 / ヒト正常鼻粘膜上皮細胞 / Capcisin / LSR / tricellulin / epithelial barrier / human nasal epithelium / NF-kB / ヒト鼻粘膜 / elF2α / 抗NF-ｋB作用 / 上皮バリア機能 / 呼吸器ウイルス / 生体防御 / 上気道 / 受容体 / ウイルス / 鼻粘膜 … More Except Principal Investigator RSウイルス / 自然免疫 / RSウィルス / RS ウイルス / ハウスキーピング / reference microRNA / プラーク法 / housekeeping gene / microRNA / 鼻汁 / IRF-3 / クラリスロマイシン / III型インターフェロン / ウイルス感染 / 中耳炎 / 上皮 / 抗菌薬 / 抗炎症 / 咽頭扁桃 / 小児 / RSV / インターフェロン / 上皮バリア / 鼻粘膜上皮 / フムロン / クルクミン / 細胞間接着装置 / 呼吸器ウイルス / 樹状細胞 / タイト結合 / ウイルス / アレルギー / 上皮細胞 / 鼻粘膜 Less

IgG4関連疾患の解析に基づいたヒトIgEのクラススイッチの制御機構の解明Principal Investigator
- Principal Investigator
  
  大國毅
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Sapporo Medical University
Analysis of the novel defense mechanism against antigens and infections in the human nasal epiheliumPrincipal Investigator
- Principal Investigator
  
  Okuni Tsuyoshi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Sapporo Medical University
Usefulness of disease-specific microRNA for respiratory syncytial virus induced lower respiratory tract inflammation
- Principal Investigator
  
  Yamamoto Keisuke
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Sapporo Medical University
Analyses of morphology and function for tricellular junction in human nasal epithelial cellsPrincipal Investigator
- Principal Investigator
  
  Okuni Tsuyoshi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Sapporo Medical University
咽頭扁桃上皮細菌受容体の発現制御による小児急性中耳炎の新たな治療戦略
- Principal Investigator
  
  才川悦子
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Sapporo Medical University
Curcumin suppresses replication of respiratory syncytial virus and release of inflammatory cytokines and chemokines in normal human nasal epithelial cells.Principal Investigator
- Principal Investigator
  
  OKUNI Tsuyoshi
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Sapporo Medical University
Interaction between mucosal epithelium and immune system in human nasal mucosa.
- Principal Investigator
  
  HIMI Tetsuo
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Sapporo Medical University
Studies on biological defense mechanism via the pattern recognition receptor for viral infection in upper airway epithelium.Principal Investigator
- Principal Investigator
  
  OHUKUNI Tsuyoshi
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Sapporo Medical University

All 2019 2017 2016 2015 2014 2013 2012 2011 Other

All Journal Article Presentation

[Journal Article] Induction of airway progenitor cells via p63 and KLF11 by Rho-kinase inhibitor Y27632 in hTERT-human nasal epithelial cells.2019
- Author(s)
  Kaneko Y, Konno T, Kakuki T, Miyata R, Ohkuni T, Kakiuchi A, Yajima R, Ohwada K, Kurose M, Himi T, Takano K, Kojima T.
- Journal Title
  
  Am J Transl Res
  
  Volume: 11 Pages: 599-611
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09350
[Journal Article] The role of transcriptional factor p63 in regulation of epithelial barrier and ciliogenesis of human nasal epithelial cells2017
- Author(s)
  Kaneko Yakuto、Kohno Takayuki、Kakuki Takuya、Takano Ken-ichi、Ogasawara Noriko、Miyata Ryo、Kikuchi Shin、Konno Takumi、Ohkuni Tsuyoshi、Yajima Ryoto、Kakiuchi Akito、Yokota Shin-ichi、Himi Tetsuo、Kojima Takashi
- Journal Title
  
  Sci Rep
  
  Volume: 7 Issue: 1 Pages: 10935-10935
- DOI
  10.1038/s41598-017-11481-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K01419, KAKENHI-PROJECT-26293370, KAKENHI-PROJECT-15K08350, KAKENHI-PROJECT-15K10788
[Journal Article] Radiological Assessment of the Anatomy of Frontal Recess Cells and the Anterior Ethimoidal Artery.2016
- Author(s)
  Okuni T, Takano K, Nomura K, Yamashita K, Abe A, Ito F, Murayama K, Shirasaki H, HImi T
- Journal Title
  
  Adv Otorhinolaryngol.
  
  Volume: 77 Pages: 46-51
- DOI
  10.1159/000441873
- ISBN
  9783318056501, 9783318056518
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K10788
[Journal Article] Accessory parotid gland tumors: A seres of 4 cases.2016
- Author(s)
  Kakuki T, Takano K, Kurose M, Kondo A, Okuni T, Ogasawara N, Himi T
- Journal Title
  
  Ear Nose Throat
  
  Volume: 95 Pages: 35-38
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K10788
[Journal Article] Carcinoma ex pleomorphic adenoma of the parotid gland: a multiple-institutional retrospective analysis in the Northern Japan Head and Neck Cancer Society.2016
- Author(s)
  Suzuki M, Matsuzuka T, Sajio S, Takahara M, Harabuchi Y, Okuni T, Himi T, Kakizaki T, Fukuda S, Yamada K, Nagahashi T, Abe T, Shinkawa H, Katagiri K, Sato H, Fukui N, Ishikawa K, Suzuki T, Kobayashi T, Saito D, Sajio S, Tateda M, Hashimoto S, Ishida A, Kakehata S, Suzuki O, Hashimoto Y, Omori K
- Journal Title
  
  Acta Otolaryngol.
  
  Volume: 136 Pages: 1154-1158
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K10788
[Journal Article] A Case Study of Anisakiasis in the Palatine Tonsils.2016
- Author(s)
  Takano K, Okuni T, Murayama K, Himi T
- Journal Title
  
  Adv Otorhinolaryngol.
  
  Volume: 77 Pages: 125-127
- DOI
  10.1159/000441903
- ISBN
  9783318056501, 9783318056518
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K10788
[Journal Article] Poly(I:C) induced microRNA-146a regulates epithelial barrier and secretion of proinflammatory cytokines in human nasal epithelial cells.2015
- Author(s)
  Miyata R, Kakuki T, Nomura K, Ohkuni T, Ogasawara N, Takano K, Konno T, Kohno T, Sawada N, Himi T, Kojima T.
- Journal Title
  
  Eur J Pharmacol.
  
  Volume: 761 Pages: 375-382
- DOI
  10.1016/j.ejphar.2015.04.031
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K08350, KAKENHI-PROJECT-15K10788, KAKENHI-PROJECT-26670746, KAKENHI-PROJECT-26293370
[Journal Article] ウイルス性炎症における上気道粘膜の役割　鼻粘膜上皮機能解析から炎症制御戦略を探る2014
- Author(s)
  氷見徹夫、高野賢一、大國毅、小笠原徳子、正木智之、小幡和史、堤裕幸、小島隆、澤田典均、横田伸一
- Journal Title
  
  日本耳鼻咽喉科感染症・エアロゾル学会会誌
  
  Volume: 2 Pages: 1-5
- NAID
  130007930871
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25861573
[Journal Article] ウイルス性上気道炎での免疫応答と鼻粘膜上皮の役割2013
- Author(s)
  氷見徹夫, 高野賢一, 大國毅, 小笠原徳子, 正木智之, 小幡和史, 堤裕幸, 小島隆, 澤田典均, 横田伸一
- Journal Title
  
  耳鼻咽喉科展望
  
  Volume: 56 Pages: 162-77
- NAID
  130004679511
- Data Source
  KAKENHI-PROJECT-23390398
[Journal Article] Regulation of tight junctions in upper airway epithelium2013
- Author(s)
  Kojima T, Takano K, Himi T(全19名1, 3, 18番)
- Journal Title
  
  Biomed Res Int
  
  Volume: 2013 Pages: 947072-947072
- DOI
  10.1155/2013/947072
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390398, KAKENHI-PROJECT-23590404, KAKENHI-PROJECT-23791916, KAKENHI-PROJECT-24659750, KAKENHI-PROJECT-24791794, KAKENHI-PROJECT-25861573, KAKENHI-PROJECT-25861575
[Journal Article] ウイルス性上気道炎での免疫応答と鼻粘膜上皮の役割2013
- Author(s)
  氷見徹夫、高野賢一、大國毅、小笠原徳子、正木智之、小幡和史、堤裕幸、小島隆、澤田典均、横田伸一
- Journal Title
  
  耳鼻咽喉科展望
  
  Volume: 56 Pages: 162-177
- NAID
  130004679511
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25861573
[Journal Article] Hop water extract inhibits double-stranded RNA-induced thymic stromal lymphopoietin release from human nasal epithelial cells2012
- Author(s)
  Fuchimoto J, Kojima T, Himi T(全12名2, 11番)
- Journal Title
  
  Am J Rhinol Allergy
  
  Volume: 26(6) Issue: 6 Pages: 433-8
- DOI
  10.2500/ajra.2012.26.3814
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390398, KAKENHI-PROJECT-23590404, KAKENHI-PROJECT-24390089, KAKENHI-PROJECT-24659750, KAKENHI-PROJECT-24791795
[Journal Article] Hop water extract inhibits double-stranded RNA-induced thymic stromal lymphopoietin release from nasal epithelial cells2012
- Author(s)
  Fuchimoto J, Kojima T, Kobayasi N, Ohkuni T, Ogasawara N, Masaki T, Obata K, Nomura K, Kondoh A, Shigyo T, Himi T, Sawada N.
- Journal Title
  
  Am J Rhinol Allergy
  
  Volume: 26(6) Pages: 433-438
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791916
[Journal Article] Poly (I;C) reduces expression of JAM-A and induces secretion of IL-8 and TNF α via distinct NF-kB pathways in human nasal epithelial cells2011
- Author(s)
  Ohkuni T, Kojima T, Ogasawara N, Masaki T, Fuchimoto J, Kamekura R, Koizumi J, Ichimiya S, Murata M, Tanaka S, Himi T, Sawada N
- Journal Title
  
  Toxicol Appl Pharmacol
  
  Volume: 250(1) Pages: 29-38
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791916
[Journal Article] Poly(I:C) reduces expression of JAM-A and induces secretion of IL-8 and TNF-・via distinct NF-・B pathways in human nasal epithelial cells2011
- Author(s)
  Ohkuni T, Kojima T , Ogasawara N, Masaki T, Fuchimoto J, Kamekura R, Koizumi J, Ichimiya S, Murata M, Tanaka S, Himi T, Sawada N
- Journal Title
  
  Toxicology and Applied Pharmacology
  
  Volume: 250 Issue: 1 Pages: 29-38
- DOI
  10.1016/j.taap.2010.09.023
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590336, KAKENHI-PROJECT-23390398, KAKENHI-PROJECT-23590404, KAKENHI-PROJECT-23590405
[Journal Article] Altered expression of claudin-1, claudin-7, and tricellulin regardless of human papilloma virus infection in human tonsillar squamous cell carcinoma.2011
- Author(s)
  Kondoh A, Takano K, Kojima T, Ohkuni T, Kamekura R, Ogasawara N, Go M, Sawada N, Himi T.
- Journal Title
  
  Acta Otolaryngol
  
  Volume: 131(8) Pages: 861-868
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791916
[Journal Article] Epithelial barrier and antigen uptake in lymphoepithelium of human adenoids2011
- Author(s)
  Ogasawara N, Kojima T, Go M, Takano K, Kamekura R, Ohkuni T, Koizumi J, Masaki T, Fuchimoto J, Obata K, Kurose M, Shintani T, Sawada N, Himi T.
- Journal Title
  
  Acta Otolaryngol
  
  Volume: 131(2) Pages: 116-123
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791916
[Journal Article] Poly(I:C)reduces expression of JAM-A and induces secretion of IL-8 and TNF-α via distinct NF-κB pathways in human nasal epithelial cells2011
- Author(s)
  Ohkuni T
- Journal Title
  
  Toxicol Appl Pharmacol
  
  Volume: 250(1) Pages: 29-38
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390398
[Journal Article] Mucosal immune barrier and antigen -presenting system in human nasal epithelial cells2011
- Author(s)
  Himi T, Takano K, Ogasawara N, Go M, Kurose M, Koizumi J, Kamekura R, Kondoh A, Ohkuni T, Masaki T, Kojima T, Sawada N, Tsutsumi H.
- Journal Title
  
  Adv Otorhinolaryngol.
  
  Volume: 72 Pages: 28-30
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791916
[Journal Article] A nuclear factor-kB signaling pathway via protein kinase C delta regulates replication of respiratory syncytial virus in polarized normal human nasal epithelial cells.2011
- Author(s)
  Masaki T, Kojima T, Okabayashi T, Ogasawara N, Ohkuni T, Obata K, Takasawa A, Murata M, Tanaka S, Hirakawa S, Fuchimoto J, Ninomiya T, Fujii N, Tsutsumi H, Himi T, Sawada N
- Journal Title
  
  Mol Biol Cell
  
  Volume: 22(13) Pages: 2144-2156
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791916
[Presentation] ウイルス感染症での鼻粘膜上皮における細気管支炎・喘鳴の発症予測因子としての鼻汁 microRNA の可能性2017
- Author(s)
  山本圭佑，小笠原徳子，大國毅，高野賢一，堤裕幸，氷見徹夫
- Organizer
  第 56 回日本鼻科学会総会・学術講演会
- Data Source
  KAKENHI-PROJECT-16K20266
[Presentation] 入院治療を要した特発性鼻出血症例の検討2016
- Author(s)
  大國　毅
- Organizer
  第78回耳鼻咽喉科臨床学会
- Place of Presentation
  城山観光ホテル（鹿児島県鹿児島市）
- Year and Date
  2016-06-23
- Data Source
  KAKENHI-PROJECT-15K10788
[Presentation] 当科における鼻副鼻腔乳頭腫症例の検討2016
- Author(s)
  大國　毅
- Organizer
  第55回日本鼻科学会
- Place of Presentation
  栃木県総合文化センター（栃木県宇都宮市）
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-15K10788
[Presentation] 上気道粘膜上皮におけるウイルス関連受容体を介した生体防御機構の検討2012
- Author(s)
  小幡和史,小島隆,正木智之,平川賢史,野村一顕,高澤啓,渕本潤,大國毅,横田伸一,澤田典均,氷見徹夫
- Place of Presentation
  下関市
- Data Source
  KAKENHI-PROJECT-23791916
[Presentation] A NF-kappa B Signaling Pathway via PKC-delta Regulates Replication of Respiratory Syncytial Virus in Polarized Normal Human Nasal Epithelial Cells2011
- Author(s)
  Masaki T, Kojima T, Ogasawara N, Ohkuni T, Obata K, Fuchimoto J, Sawada N, Himi T.
- Organizer
  XIV IRS, XXX ISIAN 2011
- Place of Presentation
  東京都
- Data Source
  KAKENHI-PROJECT-23791916
[Presentation] Poly IC Stimulation Reduces Expression of JAM-A and Induces Proinflammatory Cytokines Secretion via Distinct NF-kB Pathways in Human Nasal Epithelial Cells.2011
- Author(s)
  Ohkuni T, Himi T, Sawada N, Kojima T, Kamekura R, Ogasawara N, Masaki T.
- Organizer
  XIV IRS, XXX ISIAN 2011
- Place of Presentation
  東京都
- Data Source
  KAKENHI-PROJECT-23791916
[Presentation] Tricellular junctions in human nasal mucosa
- Author(s)
  Okuni T, Nomura K, Miyata R, Kakuki T, Ogasawara N, Kondo A, Kurose M, Ninomiya T, Takano K, Kojima T, Himi T.
- Organizer
  ISIAN(International Society of Infection and Allergy of the Nose)
- Place of Presentation
  オランダ
- Year and Date
  2014-06-20 – 2014-06-22
- Data Source
  KAKENHI-PROJECT-25861573
[Presentation] Poly IC stimulation reduces expression of JAM-A and induces proinflammatory cytokines secretion via distinct NF-kB pathways in human nasal epithelial cells.
- Author(s)
  大國　毅
- Organizer
  ISIAN 2011
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23791916

1. HIMI Tetsuo (90181114)

# of Collaborated Projects: 3 results

# of Collaborated Products: 13 results
2. TAKANO Kenichi (70404689)

# of Collaborated Projects: 3 results

# of Collaborated Products: 3 results
3. KAMEKURA Ryuta (70404697)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. SEKI Nobuhiko (30404693)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. TSUTSUMI Hiroyuki (80217348)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. KOJIMA Takashi (30260764)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
7. Yamamoto Keisuke (50738515)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. YOKOTA Shin-ichi (10325863)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. KUROSE Makoto (60404696)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. OGASAWARA Noriko (00438061)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
11. YAMAMOTO Soh (10588479)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. 才川悦子 (60404688)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 一宮慎吾 (30305221)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. KIKUCHI Shin

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. TANAKA Satoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 沢田典均

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 幸野貴之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

OHKUNI Tsuyoshi 大國 毅

大國 毅 オオクニ ツヨシ

Research Projects

Research Products

Co-Researchers

IgG4関連疾患の解析に基づいたヒトIgEのクラススイッチの制御機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of the novel defense mechanism against antigens and infections in the human nasal epiheliumPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Usefulness of disease-specific microRNA for respiratory syncytial virus induced lower respiratory tract inflammation

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analyses of morphology and function for tricellular junction in human nasal epithelial cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

咽頭扁桃上皮細菌受容体の発現制御による小児急性中耳炎の新たな治療戦略

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Curcumin suppresses replication of respiratory syncytial virus and release of inflammatory cytokines and chemokines in normal human nasal epithelial cells.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Interaction between mucosal epithelium and immune system in human nasal mucosa.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Studies on biological defense mechanism via the pattern recognition receptor for viral infection in upper airway epithelium.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Induction of airway progenitor cells via p63 and KLF11 by Rho-kinase inhibitor Y27632 in hTERT-human nasal epithelial cells.2019

Author(s)

Journal Title

Data Source

[Journal Article] The role of transcriptional factor p63 in regulation of epithelial barrier and ciliogenesis of human nasal epithelial cells2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Radiological Assessment of the Anatomy of Frontal Recess Cells and the Anterior Ethimoidal Artery.2016

Author(s)

Journal Title

DOI

ISBN

Data Source

[Journal Article] Accessory parotid gland tumors: A seres of 4 cases.2016

Author(s)

Journal Title

Data Source

[Journal Article] Carcinoma ex pleomorphic adenoma of the parotid gland: a multiple-institutional retrospective analysis in the Northern Japan Head and Neck Cancer Society.2016

Author(s)

Journal Title

Data Source

[Journal Article] A Case Study of Anisakiasis in the Palatine Tonsils.2016

Author(s)

Journal Title

DOI

OHKUNI Tsuyoshi 大國毅

大國毅オオクニツヨシ

[Journal Article] ウイルス性炎症における上気道粘膜の役割　鼻粘膜上皮機能解析から炎症制御戦略を探る2014