• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

OHKUNI Tsuyoshi  大國 毅

ORCIDConnect your ORCID iD *help
… Alternative Names

大國 毅  オオクニ ツヨシ

Less
Researcher Number 40464490
Affiliation (Current) 2025: 札幌医科大学, 医学部, 講師
Affiliation (based on the past Project Information) *help 2024: 札幌医科大学, 医学部, 講師
2018 – 2020: 札幌医科大学, 医学部, 講師
2011 – 2017: 札幌医科大学, 医学部, 助教
Review Section/Research Field
Principal Investigator
Otorhinolaryngology / Basic Section 56050:Otorhinolaryngology-related
Except Principal Investigator
Otorhinolaryngology
Keywords
Principal Investigator
ヒト鼻粘膜上皮 / タイト結合 / 自然免疫 / RSウイルス / 上皮 / IgG4 / KLF11 / CYP / ギャップ結合 / h TERT … More / ヒト鼻粘膜上皮細胞 / p63 / HMBG1 / 上気道慢性炎症 / 上皮バリア / HDAC / claudin / claudins / バリア機能 / PAR3 / ASPP2 / ヒト正常鼻粘膜上皮細胞 / Capcisin / LSR / tricellulin / epithelial barrier / human nasal epithelium / NF-kB / ヒト鼻粘膜 / elF2α / 抗NF-kB作用 / 上皮バリア機能 / 呼吸器ウイルス / 生体防御 / 上気道 / 受容体 / ウイルス / 鼻粘膜 … More
Except Principal Investigator
RSウイルス / 自然免疫 / RSウィルス / RS ウイルス / ハウスキーピング / reference microRNA / プラーク法 / housekeeping gene / microRNA / 鼻汁 / IRF-3 / クラリスロマイシン / III型インターフェロン / ウイルス感染 / 中耳炎 / 上皮 / 抗菌薬 / 抗炎症 / 咽頭扁桃 / 小児 / RSV / インターフェロン / 上皮バリア / 鼻粘膜上皮 / フムロン / クルクミン / 細胞間接着装置 / 呼吸器ウイルス / 樹状細胞 / タイト結合 / ウイルス / アレルギー / 上皮細胞 / 鼻粘膜 Less
  • Research Projects

    (8 results)
  • Research Products

    (28 results)
  • Co-Researchers

    (17 People)
  •  IgG4関連疾患の解析に基づいたヒトIgEのクラススイッチの制御機構の解明Principal Investigator

    • Principal Investigator
      大國 毅
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56050:Otorhinolaryngology-related
    • Research Institution
      Sapporo Medical University
  •  Analysis of the novel defense mechanism against antigens and infections in the human nasal epiheliumPrincipal Investigator

    • Principal Investigator
      Okuni Tsuyoshi
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56050:Otorhinolaryngology-related
    • Research Institution
      Sapporo Medical University
  •  Usefulness of disease-specific microRNA for respiratory syncytial virus induced lower respiratory tract inflammation

    • Principal Investigator
      Yamamoto Keisuke
    • Project Period (FY)
      2016 – 2017
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Otorhinolaryngology
    • Research Institution
      Sapporo Medical University
  •  Analyses of morphology and function for tricellular junction in human nasal epithelial cellsPrincipal Investigator

    • Principal Investigator
      Okuni Tsuyoshi
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Otorhinolaryngology
    • Research Institution
      Sapporo Medical University
  •  咽頭扁桃上皮細菌受容体の発現制御による小児急性中耳炎の新たな治療戦略

    • Principal Investigator
      才川 悦子
    • Project Period (FY)
      2014 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Otorhinolaryngology
    • Research Institution
      Sapporo Medical University
  •  Curcumin suppresses replication of respiratory syncytial virus and release of inflammatory cytokines and chemokines in normal human nasal epithelial cells.Principal Investigator

    • Principal Investigator
      OKUNI Tsuyoshi
    • Project Period (FY)
      2013 – 2014
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Otorhinolaryngology
    • Research Institution
      Sapporo Medical University
  •  Interaction between mucosal epithelium and immune system in human nasal mucosa.

    • Principal Investigator
      HIMI Tetsuo
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Otorhinolaryngology
    • Research Institution
      Sapporo Medical University
  •  Studies on biological defense mechanism via the pattern recognition receptor for viral infection in upper airway epithelium.Principal Investigator

    • Principal Investigator
      OHUKUNI Tsuyoshi
    • Project Period (FY)
      2011 – 2012
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Otorhinolaryngology
    • Research Institution
      Sapporo Medical University

All 2019 2017 2016 2015 2014 2013 2012 2011 Other

All Journal Article Presentation

  • [Journal Article] Induction of airway progenitor cells via p63 and KLF11 by Rho-kinase inhibitor Y27632 in hTERT-human nasal epithelial cells.2019

    • Author(s)
      Kaneko Y, Konno T, Kakuki T, Miyata R, Ohkuni T, Kakiuchi A, Yajima R, Ohwada K, Kurose M, Himi T, Takano K, Kojima T.
    • Journal Title

      Am J Transl Res

      Volume: 11 Pages: 599-611

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K09350
  • [Journal Article] The role of transcriptional factor p63 in regulation of epithelial barrier and ciliogenesis of human nasal epithelial cells2017

    • Author(s)
      Kaneko Yakuto、Kohno Takayuki、Kakuki Takuya、Takano Ken-ichi、Ogasawara Noriko、Miyata Ryo、Kikuchi Shin、Konno Takumi、Ohkuni Tsuyoshi、Yajima Ryoto、Kakiuchi Akito、Yokota Shin-ichi、Himi Tetsuo、Kojima Takashi
    • Journal Title

      Sci Rep

      Volume: 7 Issue: 1 Pages: 10935-10935

    • DOI

      10.1038/s41598-017-11481-w

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K01419, KAKENHI-PROJECT-26293370, KAKENHI-PROJECT-15K08350, KAKENHI-PROJECT-15K10788
  • [Journal Article] Radiological Assessment of the Anatomy of Frontal Recess Cells and the Anterior Ethimoidal Artery.2016

    • Author(s)
      Okuni T, Takano K, Nomura K, Yamashita K, Abe A, Ito F, Murayama K, Shirasaki H, HImi T
    • Journal Title

      Adv Otorhinolaryngol.

      Volume: 77 Pages: 46-51

    • DOI

      10.1159/000441873

    • ISBN
      9783318056501, 9783318056518
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K10788
  • [Journal Article] Accessory parotid gland tumors: A seres of 4 cases.2016

    • Author(s)
      Kakuki T, Takano K, Kurose M, Kondo A, Okuni T, Ogasawara N, Himi T
    • Journal Title

      Ear Nose Throat

      Volume: 95 Pages: 35-38

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K10788
  • [Journal Article] Carcinoma ex pleomorphic adenoma of the parotid gland: a multiple-institutional retrospective analysis in the Northern Japan Head and Neck Cancer Society.2016

    • Author(s)
      Suzuki M, Matsuzuka T, Sajio S, Takahara M, Harabuchi Y, Okuni T, Himi T, Kakizaki T, Fukuda S, Yamada K, Nagahashi T, Abe T, Shinkawa H, Katagiri K, Sato H, Fukui N, Ishikawa K, Suzuki T, Kobayashi T, Saito D, Sajio S, Tateda M, Hashimoto S, Ishida A, Kakehata S, Suzuki O, Hashimoto Y, Omori K
    • Journal Title

      Acta Otolaryngol.

      Volume: 136 Pages: 1154-1158

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K10788
  • [Journal Article] A Case Study of Anisakiasis in the Palatine Tonsils.2016

    • Author(s)
      Takano K, Okuni T, Murayama K, Himi T
    • Journal Title

      Adv Otorhinolaryngol.

      Volume: 77 Pages: 125-127

    • DOI

      10.1159/000441903

    • ISBN
      9783318056501, 9783318056518
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K10788
  • [Journal Article] Poly(I:C) induced microRNA-146a regulates epithelial barrier and secretion of proinflammatory cytokines in human nasal epithelial cells.2015

    • Author(s)
      Miyata R, Kakuki T, Nomura K, Ohkuni T, Ogasawara N, Takano K, Konno T, Kohno T, Sawada N, Himi T, Kojima T.
    • Journal Title

      Eur J Pharmacol.

      Volume: 761 Pages: 375-382

    • DOI

      10.1016/j.ejphar.2015.04.031

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15K08350, KAKENHI-PROJECT-15K10788, KAKENHI-PROJECT-26670746, KAKENHI-PROJECT-26293370
  • [Journal Article] ウイルス性炎症における上気道粘膜の役割 鼻粘膜上皮機能解析から炎症制御戦略を探る2014

    • Author(s)
      氷見徹夫、高野賢一、大國毅、小笠原徳子、正木智之、小幡和史、堤裕幸、小島隆、澤田典均、横田伸一
    • Journal Title

      日本耳鼻咽喉科感染症・エアロゾル学会会誌

      Volume: 2 Pages: 1-5

    • NAID

      130007930871

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25861573
  • [Journal Article] ウイルス性上気道炎での免疫応答と鼻粘膜上皮の役割2013

    • Author(s)
      氷見徹夫, 高野賢一, 大國毅, 小笠原徳子, 正木智之, 小幡和史, 堤裕幸, 小島隆, 澤田典均, 横田伸一
    • Journal Title

      耳鼻咽喉科展望

      Volume: 56 Pages: 162-77

    • NAID

      130004679511

    • Data Source
      KAKENHI-PROJECT-23390398
  • [Journal Article] Regulation of tight junctions in upper airway epithelium2013

    • Author(s)
      Kojima T, Takano K, Himi T(全19名1, 3, 18番)
    • Journal Title

      Biomed Res Int

      Volume: 2013 Pages: 947072-947072

    • DOI

      10.1155/2013/947072

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390398, KAKENHI-PROJECT-23590404, KAKENHI-PROJECT-23791916, KAKENHI-PROJECT-24659750, KAKENHI-PROJECT-24791794, KAKENHI-PROJECT-25861573, KAKENHI-PROJECT-25861575
  • [Journal Article] ウイルス性上気道炎での免疫応答と鼻粘膜上皮の役割2013

    • Author(s)
      氷見徹夫、高野賢一、大國毅、小笠原徳子、正木智之、小幡和史、堤裕幸、小島隆、澤田典均、横田伸一
    • Journal Title

      耳鼻咽喉科展望

      Volume: 56 Pages: 162-177

    • NAID

      130004679511

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25861573
  • [Journal Article] Hop water extract inhibits double-stranded RNA-induced thymic stromal lymphopoietin release from human nasal epithelial cells2012

    • Author(s)
      Fuchimoto J, Kojima T, Himi T(全12名2, 11番)
    • Journal Title

      Am J Rhinol Allergy

      Volume: 26(6) Issue: 6 Pages: 433-8

    • DOI

      10.2500/ajra.2012.26.3814

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390398, KAKENHI-PROJECT-23590404, KAKENHI-PROJECT-24390089, KAKENHI-PROJECT-24659750, KAKENHI-PROJECT-24791795
  • [Journal Article] Hop water extract inhibits double-stranded RNA-induced thymic stromal lymphopoietin release from nasal epithelial cells2012

    • Author(s)
      Fuchimoto J, Kojima T, Kobayasi N, Ohkuni T, Ogasawara N, Masaki T, Obata K, Nomura K, Kondoh A, Shigyo T, Himi T, Sawada N.
    • Journal Title

      Am J Rhinol Allergy

      Volume: 26(6) Pages: 433-438

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23791916
  • [Journal Article] Poly (I;C) reduces expression of JAM-A and induces secretion of IL-8 and TNF α via distinct NF-kB pathways in human nasal epithelial cells2011

    • Author(s)
      Ohkuni T, Kojima T, Ogasawara N, Masaki T, Fuchimoto J, Kamekura R, Koizumi J, Ichimiya S, Murata M, Tanaka S, Himi T, Sawada N
    • Journal Title

      Toxicol Appl Pharmacol

      Volume: 250(1) Pages: 29-38

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23791916
  • [Journal Article] Poly(I:C) reduces expression of JAM-A and induces secretion of IL-8 and TNF-・via distinct NF-・B pathways in human nasal epithelial cells2011

    • Author(s)
      Ohkuni T, Kojima T , Ogasawara N, Masaki T, Fuchimoto J, Kamekura R, Koizumi J, Ichimiya S, Murata M, Tanaka S, Himi T, Sawada N
    • Journal Title

      Toxicology and Applied Pharmacology

      Volume: 250 Issue: 1 Pages: 29-38

    • DOI

      10.1016/j.taap.2010.09.023

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590336, KAKENHI-PROJECT-23390398, KAKENHI-PROJECT-23590404, KAKENHI-PROJECT-23590405
  • [Journal Article] Altered expression of claudin-1, claudin-7, and tricellulin regardless of human papilloma virus infection in human tonsillar squamous cell carcinoma.2011

    • Author(s)
      Kondoh A, Takano K, Kojima T, Ohkuni T, Kamekura R, Ogasawara N, Go M, Sawada N, Himi T.
    • Journal Title

      Acta Otolaryngol

      Volume: 131(8) Pages: 861-868

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23791916
  • [Journal Article] Epithelial barrier and antigen uptake in lymphoepithelium of human adenoids2011

    • Author(s)
      Ogasawara N, Kojima T, Go M, Takano K, Kamekura R, Ohkuni T, Koizumi J, Masaki T, Fuchimoto J, Obata K, Kurose M, Shintani T, Sawada N, Himi T.
    • Journal Title

      Acta Otolaryngol

      Volume: 131(2) Pages: 116-123

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23791916
  • [Journal Article] Poly(I:C)reduces expression of JAM-A and induces secretion of IL-8 and TNF-α via distinct NF-κB pathways in human nasal epithelial cells2011

    • Author(s)
      Ohkuni T
    • Journal Title

      Toxicol Appl Pharmacol

      Volume: 250(1) Pages: 29-38

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390398
  • [Journal Article] Mucosal immune barrier and antigen -presenting system in human nasal epithelial cells2011

    • Author(s)
      Himi T, Takano K, Ogasawara N, Go M, Kurose M, Koizumi J, Kamekura R, Kondoh A, Ohkuni T, Masaki T, Kojima T, Sawada N, Tsutsumi H.
    • Journal Title

      Adv Otorhinolaryngol.

      Volume: 72 Pages: 28-30

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23791916
  • [Journal Article] A nuclear factor-kB signaling pathway via protein kinase C delta regulates replication of respiratory syncytial virus in polarized normal human nasal epithelial cells.2011

    • Author(s)
      Masaki T, Kojima T, Okabayashi T, Ogasawara N, Ohkuni T, Obata K, Takasawa A, Murata M, Tanaka S, Hirakawa S, Fuchimoto J, Ninomiya T, Fujii N, Tsutsumi H, Himi T, Sawada N
    • Journal Title

      Mol Biol Cell

      Volume: 22(13) Pages: 2144-2156

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23791916
  • [Presentation] ウイルス感染症での鼻粘膜上皮における細気管支炎・喘鳴の発症予測因子としての鼻汁 microRNA の可能性2017

    • Author(s)
      山本圭佑,小笠原徳子,大國毅,高野賢一,堤裕幸,氷見徹夫
    • Organizer
      第 56 回 日本鼻科学会 総会・学術講演会
    • Data Source
      KAKENHI-PROJECT-16K20266
  • [Presentation] 入院治療を要した特発性鼻出血症例の検討2016

    • Author(s)
      大國 毅
    • Organizer
      第78回耳鼻咽喉科臨床学会
    • Place of Presentation
      城山観光ホテル(鹿児島県鹿児島市)
    • Year and Date
      2016-06-23
    • Data Source
      KAKENHI-PROJECT-15K10788
  • [Presentation] 当科における鼻副鼻腔乳頭腫症例の検討2016

    • Author(s)
      大國 毅
    • Organizer
      第55回日本鼻科学会
    • Place of Presentation
      栃木県総合文化センター(栃木県宇都宮市)
    • Year and Date
      2016-10-13
    • Data Source
      KAKENHI-PROJECT-15K10788
  • [Presentation] 上気道粘膜上皮におけるウイルス関連受容体を介した生体防御機構の検討2012

    • Author(s)
      小幡和史,小島隆,正木智之,平川賢史,野村一顕,高澤啓,渕本潤,大國毅,横田伸一,澤田典均,氷見徹夫
    • Place of Presentation
      下関市
    • Data Source
      KAKENHI-PROJECT-23791916
  • [Presentation] A NF-kappa B Signaling Pathway via PKC-delta Regulates Replication of Respiratory Syncytial Virus in Polarized Normal Human Nasal Epithelial Cells2011

    • Author(s)
      Masaki T, Kojima T, Ogasawara N, Ohkuni T, Obata K, Fuchimoto J, Sawada N, Himi T.
    • Organizer
      XIV IRS, XXX ISIAN 2011
    • Place of Presentation
      東京都
    • Data Source
      KAKENHI-PROJECT-23791916
  • [Presentation] Poly IC Stimulation Reduces Expression of JAM-A and Induces Proinflammatory Cytokines Secretion via Distinct NF-kB Pathways in Human Nasal Epithelial Cells.2011

    • Author(s)
      Ohkuni T, Himi T, Sawada N, Kojima T, Kamekura R, Ogasawara N, Masaki T.
    • Organizer
      XIV IRS, XXX ISIAN 2011
    • Place of Presentation
      東京都
    • Data Source
      KAKENHI-PROJECT-23791916
  • [Presentation] Tricellular junctions in human nasal mucosa

    • Author(s)
      Okuni T, Nomura K, Miyata R, Kakuki T, Ogasawara N, Kondo A, Kurose M, Ninomiya T, Takano K, Kojima T, Himi T.
    • Organizer
      ISIAN(International Society of Infection and Allergy of the Nose)
    • Place of Presentation
      オランダ
    • Year and Date
      2014-06-20 – 2014-06-22
    • Data Source
      KAKENHI-PROJECT-25861573
  • [Presentation] Poly IC stimulation reduces expression of JAM-A and induces proinflammatory cytokines secretion via distinct NF-kB pathways in human nasal epithelial cells.

    • Author(s)
      大國 毅
    • Organizer
      ISIAN 2011
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-23791916
  • 1.  HIMI Tetsuo (90181114)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 13 results
  • 2.  TAKANO Kenichi (70404689)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 3 results
  • 3.  KAMEKURA Ryuta (70404697)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 4.  SEKI Nobuhiko (30404693)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  TSUTSUMI Hiroyuki (80217348)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 6.  KOJIMA Takashi (30260764)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 4 results
  • 7.  Yamamoto Keisuke (50738515)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 8.  YOKOTA Shin-ichi (10325863)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  KUROSE Makoto (60404696)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  OGASAWARA Noriko (00438061)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 11.  YAMAMOTO Soh (10588479)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 12.  才川 悦子 (60404688)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  一宮 慎吾 (30305221)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  KIKUCHI Shin
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 15.  TANAKA Satoshi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 16.  沢田 典均
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 17.  幸野 貴之
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

URL: 

Are you sure that you want to link your ORCID iD to your KAKEN Researcher profile?
* This action can be performed only by the researcher himself/herself who is listed on the KAKEN Researcher’s page. Are you sure that this KAKEN Researcher’s page is your page?

この研究者とORCID iDの連携を行いますか?
※ この処理は、研究者本人だけが実行できます。

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi