SEMBA Shingo 仙葉愼吾

Researcher Number	40466496
Other IDs
Affiliation (based on the past Project Information) *help	2022 – 2023: 北海道医療大学, 歯学部, 助教 2017: 北海道大学, 医学研究院, 学術研究員 2016 – 2017: 北海道大学, 医学研究科, 特任助教 2013 – 2015: 北海道大学, 医学(系)研究科(研究院), 特任助教 2013: 北海道大学, 医学研究科, 特任助教 2010 – 2011: 旭川医科大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 57020:Oral pathobiological science-related / Biomedical engineering/Biomaterial science and engineering / General pharmacology Except Principal Investigator Medium-sized Section 57:Oral science and related fields / Biomedical engineering/Biomaterial science and engineering / Human pathology / Biomedical engineering/Biological material science
Keywords	Principal Investigator FRET / 唾液 / エキソソーム / FRETセンサー / リキッドバイオプシー / 唾液エキソソーム / 再生医工学材料 / 軟骨再生 / ハイドロゲル / ダブルネットワークゲル … More / 生体材料 / 再生医工材料 / MYPT / MYPT1 / ミオシンホスファターゼ / 一酸化窒素 / 血管平滑筋 / シグナル伝達 … More Except Principal Investigator 蛍光共鳴エネルギー移動 / 細胞外メッセンジャー / シリカ不織布 / 蛍光リガンド / 蛍光タンパク質 / イメージング / 蛍光センサー / リガンド / COVID-19 / 不織布 / FRET / 抗原抗体反応 / 蛍光アッセイ / 軟骨再生 / 再生医学 / 生体材料 / 免疫染色 / 病理 / 成長因子 / サイトカイン / 炎症細胞 / 血管拡張薬 / 膠原病 / 肺線維症 / 遺伝子解析 / 免疫組織化学染色 / ニース分類 / 肺高血圧 / 軟骨分子 / 質量分析 / 細胞メカニクス / 光イメージング / 細胞内情報伝達 / 自然再生 / 軟骨分化 / ダブルネットワークゲル Less

唾液エキソソームによるリキッドバイオプシーを可能とするFRETセンサーの開発Principal Investigator
- Principal Investigator
  
  仙葉愼吾
- Project Period (FY)
  2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57020:Oral pathobiological science-related
- Research Institution
  Health Sciences University of Hokkaido
Development of an extracellular messenger imaging method using silica nonwoven fabric and competitive FRET
- Principal Investigator
  
  Tanimura Akihiko
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 57:Oral science and related fields
- Research Institution
  Health Sciences University of Hokkaido
Analysis of microenvironment and exploration of new biomarker for pulmonary arterial hypertention
- Principal Investigator
  
  Tanino Mishie
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Hokkaido University
多機能ゲルによる関節軟骨自然再生誘導法の最適化に関わる機序の解明と制御
- Principal Investigator
  
  北村信人
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biomedical engineering/Biomaterial science and engineering
- Research Institution
  Hokkaido University
Explore the molecular mechanism of cellular differentiation induced by PAMPS gels.Principal Investigator
- Principal Investigator
  
  Semba Shingo
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biomedical engineering/Biomaterial science and engineering
- Research Institution
  Hokkaido University
Clarification of signal transmission mechanism in mesenchymal cells during spontaneous cartilage regeneration induced by multi-functional synthetic gel
- Principal Investigator
  
  YASUDA Kazunori
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  Hokkaido University
Identification of Protein Phosphatase that Controls the Activity of Myosin Light Chain PhosphatasePrincipal Investigator
- Principal Investigator
  
  SEMBA Shingo
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General pharmacology
- Research Institution
  Asahikawa Medical College

All 2016 2015 2014 2011 2010

All Journal Article Presentation

[Journal Article] Synthetic PAMPS gel activates BMP/Smad signaling pathway in ATDC5 cells, which plays a significant role in the gel-induced chondrogenic differentiation.2016
- Author(s)
  Goto K, Kimura T, Kitamura N, Semba S, Ohmiya Y, Aburatani S, Matsukura S, Tsuda M, Kurokawa T, Gong JP, Tanaka S, Yasuda K.
- Journal Title
  
  J Biomed Mater Res A
  
  Volume: 未定 Issue: 3 Pages: 734-746
- DOI
  10.1002/jbm.a.35615
- NAID
  120005981343
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K15106, KAKENHI-PROJECT-24225006, KAKENHI-PROJECT-15H03014, KAKENHI-PROJECT-25350548, KAKENHI-PROJECT-25460471
[Journal Article] Oxazolone-induced over-expression of focal adhesion kinase in colonic epithelial cells of colitis mouse model2010
- Author(s)
  Yanju Ma, Shingo Semba, Atsuo Maemoto, Masayuki Takeuchi, Isamu Kameshita, Atsuhiko Ishida, Sanae Kato, Tsuyoshi Katoh, Yunpeng Liu, Takanobu Taniguchi
- Journal Title
  
  FEBS Letters
  
  Volume: 584 Pages: 3949-3954
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790240
[Journal Article] Oxazolone-induced over-expression of focal adhesion kinase in colonic epithelial cells of colitis mouse model.2010
- Author(s)
  Yanju Ma, Shingo Semba, Atsuo Maemoto, Masayuki Takeuchi, Isamu Kameshita, Atsuhiko Ishida, Sanae Kato, Tsuyoshi Katoh, Yunpeng Liu, Takanobu Taniguchi
- Journal Title
  
  FEBS Letters
  
  Volume: 584 Pages: 3949-3954
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790240
[Presentation] ハイドロキシアパタイト複合化PAMPS PDMAAmダブルネットワークゲル人工軟骨の関節内におけるin vivo 骨接着性評価2016
- Author(s)
  和田進、北村信人、野々山貴行、木山竜二、仙葉慎吾、小野寺純、横田正司、後藤佳子、比嘉浩太郎、黒川孝幸、Jian Ping Gong、安田和則
- Organizer
  第31回日本整形外科学会基礎学術集会
- Place of Presentation
  福岡国際会議場（福岡県福岡市）
- Year and Date
  2016-10-14
- Data Source
  KAKENHI-PROJECT-15H03014
[Presentation] 高強度ダブルネットワークゲル人工軟骨の生体内骨接着プロセスとそのメカニズムの解明2016
- Author(s)
  和田進、北村信人、野々山貴行、木山竜二、黒川孝幸、仙葉慎吾、後藤佳子、小野寺純、Jian Ping Gong、安田和則
- Organizer
  第43回日本臨床バイオメカニクス学会
- Place of Presentation
  北海道立道民活動センターかでる2・7（北海道札幌市）
- Year and Date
  2016-10-08
- Data Source
  KAKENHI-PROJECT-15H03014
[Presentation] ハイドロゲルが誘導する軟骨細胞分化における細胞内情報伝達機構の解明2015
- Author(s)
  仙葉愼吾
- Organizer
  第5回北海道探索病理学研究シンポジウム
- Place of Presentation
  ニューオータニイン札幌（北海道、札幌市）
- Year and Date
  2015-10-24
- Invited
- Data Source
  KAKENHI-PROJECT-25350548
[Presentation] PAMPSゲルが誘導する軟骨細胞分化における細胞内情報伝達機構の解明2014
- Author(s)
  仙葉愼吾
- Organizer
  ソフト＆ウェットマテリアルが拓くライフイノベーション第１回研究成果報告シンポジウム
- Place of Presentation
  北海道大学（北海道・札幌市）
- Year and Date
  2014-06-26
- Data Source
  KAKENHI-PROJECT-25350548
[Presentation] Activation of focal adhesion kinase is necessary for repairing epithelial barrier in Caco-2 cell monolayer2011
- Author(s)
  Yanju Ma, Shingo Semba, Mikihiro Fujiya, Yutaka Kohgo, Takanobu Taniguchi
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜/横浜市
- Year and Date
  2011-12-16
- Data Source
  KAKENHI-PROJECT-22790240
[Presentation] Activation of focal adhesion kinase is necessary for repairing epithelial barrier in Caco-2 cell monolayer2011
- Author(s)
  Yanju Ma,Shingo Semba, Mikihiro Fujiya, Yutaka Kohgo and Takanobu Taniguchi
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2011-12-16
- Data Source
  KAKENHI-PROJECT-22790240
[Presentation] Identification of Protein Phosphatase that Controls the Activity of Myosin Light Chain Phosphatase.2010
- Author(s)
  Shingo Semba, Yanju Ma, Takanobu Taniguchi
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2010-12-10
- Data Source
  KAKENHI-PROJECT-22790240
[Presentation] Identification of Protein Phosphatase that Controls the Activity of Myosin Light Chain Phosphatase2010
- Author(s)
  Shingo Semba , Yanju Ma, and Takanobu Taniguchi
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Year and Date
  2010-12-10
- Data Source
  KAKENHI-PROJECT-22790240
[Presentation] Oxazolone-induced over-expression of focal adhesion kinase in colonic epithelial cells of colitis mouse model.2010
- Author(s)
  Yanju Ma, Shingo Semba, Takanobu Taniguchi
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2010-12-10
- Data Source
  KAKENHI-PROJECT-22790240
[Presentation] Oxazolone-induced over-expression of focal adhesion kinase in colonic epithelial cell of colitis mouse model2010
- Author(s)
  Yanju Ma, Shingo Semba, and Takanobu Taniguchi
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Year and Date
  2010-12-10
- Data Source
  KAKENHI-PROJECT-22790240

1. TSUDA Masumi (30431307)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
2. YASUDA Kazunori (20166507)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. KUROKAWA Takayuki (40451439)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
4. KITAMURA Nobuto (80447044)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
5. Tanimura Akihiko (70217149)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. 根津顕弘 (00305913)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. OMIYA Yoshihiro (20223951)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. OHASHI Toshiro (30270812)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. TANAKA Shinya (70261287)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. Tanino Mishie (90360908)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 辻野一三 (00344507)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 谷野功典 (10443863)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. グン剣萍 (20250417)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 森田貴雄 (20326549)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. ぐん剣萍

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

SEMBA Shingo 仙葉 愼吾

Research Projects

Research Products

Co-Researchers

唾液エキソソームによるリキッドバイオプシーを可能とするFRETセンサーの開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of an extracellular messenger imaging method using silica nonwoven fabric and competitive FRET

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of microenvironment and exploration of new biomarker for pulmonary arterial hypertention

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

多機能ゲルによる関節軟骨自然再生誘導法の最適化に関わる機序の解明と制御

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Explore the molecular mechanism of cellular differentiation induced by PAMPS gels.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Clarification of signal transmission mechanism in mesenchymal cells during spontaneous cartilage regeneration induced by multi-functional synthetic gel

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification of Protein Phosphatase that Controls the Activity of Myosin Light Chain PhosphatasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Synthetic PAMPS gel activates BMP/Smad signaling pathway in ATDC5 cells, which plays a significant role in the gel-induced chondrogenic differentiation.2016

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Oxazolone-induced over-expression of focal adhesion kinase in colonic epithelial cells of colitis mouse model2010

Author(s)

Journal Title

Data Source

[Journal Article] Oxazolone-induced over-expression of focal adhesion kinase in colonic epithelial cells of colitis mouse model.2010

Author(s)

Journal Title

Data Source

[Presentation] ハイドロキシアパタイト複合化PAMPS PDMAAmダブルネットワークゲル人工軟骨の関節内におけるin vivo 骨接着性評価2016

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] 高強度ダブルネットワークゲル人工軟骨の生体内骨接着プロセスとそのメカニズムの解明2016

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] ハイドロゲルが誘導する軟骨細胞分化における細胞内情報伝達機構の解明2015

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] PAMPSゲルが誘導する軟骨細胞分化における細胞内情報伝達機構の解明2014

Author(s)

SEMBA Shingo 仙葉愼吾