Tsukumo Yoshinori 築茂由則

… Alternative Names

TSUKUMO Yosinori 築茂由則

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Researcher Number	40469630
Other IDs
Affiliation (Current)	2025: 国立医薬品食品衛生研究所, 遺伝子医薬部, 室長
Affiliation (based on the past Project Information) *help	2025: 国立医薬品食品衛生研究所, 遺伝子医薬部, 室長 2023: 国立医薬品食品衛生研究所, 遺伝子医薬部, 室長 2019 – 2022: 国立医薬品食品衛生研究所, 遺伝子医薬部, 主任研究官 2016 – 2017: 国立医薬品食品衛生研究所, 遺伝子医薬部, 主任研究官 2011: 公益財団法人がん研究会, がん化学療法センターゲノム研究部, 研究員 2011: 公益財団法人がん研究会, がん化学療法センター・ゲノム研究部, 研究員 2010: (財)癌研究会, 癌化学療法センターゲノム研究部, 研究員
Review Section/Research Field	Principal Investigator Basic Section 58020:Hygiene and public health-related: including laboratory approach / Basic Section 90140:Medical technology assessment-related / Basic Section 50020:Tumor diagnostics and therapeutics-related / Tumor diagnostics / Tumor biology
Keywords	Principal Investigator EGFR / エクソソーム / リボソームプロファイリング / バイオマーカー / 肺がん / 翻訳 / 検体 / 性能評価 / パンデミック / 核酸増幅検査薬 … More / がん / コンパニオン診断 / cell free RNA / exosome / cfDNA / cfRNA / 耐性克服 / 複合体形成 / 糖鎖修飾 / 分泌糖タンパク / 分子標的 / CRISPR-Cas9 / 翻訳調節 / 癌 / EGFR阻害薬 / L858R / ゲノム編集 / 分子標的薬 / 飢餓 / 腫瘍 / 翻訳開始因子 / リボソーム / mRNA / 小胞体 / ストレス応答タンパク Less

核酸増幅検査薬の性能評価に用いる革新的試料の開発Principal Investigator
- Principal Investigator
  
  築茂由則
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 58020:Hygiene and public health-related: including laboratory approach
- Research Institution
  National Institute of Health Sciences
cell free mRNAからの微量遺伝子変異検出法の確立とその応用Principal Investigator
- Principal Investigator
  
  築茂由則
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 90140:Medical technology assessment-related
- Research Institution
  National Institute of Health Sciences
Development of novel therapeutic and diagnostic methods for EGFR-mutated lung cancersPrincipal Investigator
- Principal Investigator
  
  Tsukumo Yoshinori
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  National Institute of Health Sciences
Screening of biomarkers to predict the drug efficacy based on translation profilingPrincipal Investigator
- Principal Investigator
  
  Tsukumo Yoshinori
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor diagnostics
- Research Institution
  National Institute of Health Sciences
Studies on selective translation mechanism of stress response Protein under global translational repressionPrincipal Investigator
- Principal Investigator
  
  TSUKUMO Yosinori
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor biology
- Research Institution
  公益財団法人がん研究会
   Japanese Foundation For Cancer Research

All 2024 2023 2022 2021 2020 2019 2017 2016 2012 2011

All Journal Article Presentation Book

[Book] 次世代医薬とバイオ医療　第8章個別化医療に向けた診断用医薬品コンパニオン診断薬2022
- Author(s)
  1.築茂由則, 井上貴雄
- Total Pages
  16
- Publisher
  東京化学同人
- Data Source
  KAKENHI-PROJECT-19K07724
[Journal Article] Current Status and Regulatory Issues of Companion Diagnostics in Japan2024
- Author(s)
  Tsukumo Y, Inoue T
- Journal Title
  
  Gan To Kagaku Ryoho
  
  Volume: 51 Pages: 368-377
- Data Source
  KAKENHI-PROJECT-22K12899
[Journal Article] Survey and Consideration of the Composition of COVID-19 Diagnostic Nucleic Acid Amplification Tests Approved for Use in the Early Stage of COVID-19 Pandemic2023
- Author(s)
  築茂由則, 吉田徳幸, 大岡伸通, 内田恵理子, 山本真梨子, 野口耕司, 鈴木孝昌, 本間正充, 合田幸広, 井上貴雄
- Journal Title
  
  Pharmaceutical and Medical Device Regulatory Science
  
  Volume: 54 Issue: 2 Pages: 148-161
- DOI
  10.51018/pmdrs.54.2_148
- ISSN
  1884-6076, 2436-6226
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K12899
[Journal Article] Development of Gilteritinib-Based Chimeric Small Molecules that Potently Induce Degradation of FLT3-ITD Protein2022
- Author(s)
  Ohoka Nobumichi、Suzuki Masanori、Uchida Takuya、Tsuji Genichiro、Tsukumo Yoshinori、Yoshida Masayuki、Inoue Takao、Demizu Yosuke、Ohki Hitoshi、Naito Mikihiko
- Journal Title
  
  ACS Medicinal Chemistry Letters
  
  Volume: 13 Issue: 12 Pages: 1885-1891
- DOI
  10.1021/acsmedchemlett.2c00402
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K05320, KAKENHI-PROJECT-21K06490, KAKENHI-PROJECT-19K07724, KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-21H02777
[Journal Article] Development of a potent small-molecule degrader against oncogenic BRAFV600E protein that evades paradoxical MAPK activation.2022
- Author(s)
  Ohoka N, Suzuki M, Uchida T, Tsukumo Y, Yoshida M, Inoue T, Ohki H, Naito M.
- Journal Title
  
  Cancer Sci.
  
  Volume: 113 Issue: 8 Pages: 2828-2838
- DOI
  10.1111/cas.15401
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06490, KAKENHI-PROJECT-19K07724, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-21H02777
[Journal Article] Protocols for Synthesis of and the Methods to Evaluate the Anticancer Effects2021
- Author(s)
  Tsukumo Yoshinori、Tsuji Genichiro、Yokoo Hidetomo、Shibata Norihito、Ohoka Nobumichi、Demizu Yosuke、Naito Mikihiko
- Journal Title
  
  Methods Mol. Biol.
  
  Volume: 2365 Pages: 331-347
- DOI
  10.1007/978-1-0716-1665-9_18
- ISBN
  9781071616642, 9781071616659
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-18K07311, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-21H02777, KAKENHI-PROJECT-19K07724, KAKENHI-PROJECT-21K05320
[Journal Article] Influence of EGFR-activating mutations on sensitivity to tyrosine kinase inhibitors in a KRAS mutant non-small cell lung cancer cell line.2020
- Author(s)
  Tsukumo Y, Naito M, Suzuki T.
- Journal Title
  
  PLoS One
  
  Volume: 15 Issue: 3 Pages: 1-16
- DOI
  10.1371/journal.pone.0229712
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07724
[Journal Article] Preparation of the standard cell lines for reference mutations in cancer gene-panels by genome editing in HEK 293T/17 cells.2020
- Author(s)
  Suzuki T, Tsukumo Y, Furihata C, Naito M, Kohara A.
- Journal Title
  
  Genes Environ
  
  Volume: 42 Issue: 1 Pages: 1-12
- DOI
  10.1186/s41021-020-0147-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07724
[Journal Article] eIF4A inhibition circumvents uncontrolled DNA replication mediated by 4E-BP1 loss in pancreatic cancer.2019
- Author(s)
  Muller D, Shin S, Goullet de Rugy T, Samain R, Baer R, Strehaiano M, Masvidal-Sanz L, Guillermet-Guibert J, Jean C, Tsukumo Y, Sonenberg N, Marion F, Guilbaud N, Hoffmann JS, Larsson O, Bousquet C, Pyronnet S, Martineau Y.
- Journal Title
  
  JCI Insight
  
  Volume: 4 Pages: 1-17
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07724
[Journal Article] Targeted Protein Degradation by Chimeric Small Molecules, PROTACs and SNIPERs.2019
- Author(s)
  Naito M, Ohoka N, Shibata N, Tsukumo Y.
- Journal Title
  
  Front Chem.
  
  Volume: 7 Pages: 849-849
- DOI
  10.3389/fchem.2019.00849
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06567, KAKENHI-PROJECT-19K07724, KAKENHI-PLANNED-18H05502
[Journal Article] Current and Future Issues of Companion Diagnostics2017
- Author(s)
  築茂由則, 鈴木孝昌, 内藤幹彦
- Journal Title
  
  Regulatory Science of Medical Products
  
  Volume: 7 Issue: 2 Pages: 71-80
- DOI
  10.14982/rsmp.7.71
- NAID
  130007040567
- ISSN
  2185-7113, 2189-0447
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K18444
[Journal Article] Control of embryonic stem cell self-renewal and differentiation via coordinated alternative splicing and translation of YY2.2016
- Author(s)
  Tahmasebi S, Jafarnejad SM, Tam IS, Gonatopoulos-Pournatzis T, Matta-Camacho E, Tsukumo Y, Yanagiya A, Li W, Atlasi Y, Caron M, Braunschweig U, Pearl D, Khoutorsky A, Gkogkas CG, Nadon R, Bourque G, Yang XJ, Tian B, Stunnenberg HG, Yamanaka Y, Blencowe BJ, Giguere V, Sonenberg N.
- Journal Title
  
  Proc Natl Acad Sci U S A
  
  Volume: 113 Issue: 44 Pages: 12360-12367
- DOI
  10.1073/pnas.1615540113
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K18444
[Journal Article] Translation control during prolonged mTORC1 inhibition mediated by 4E-BP3.2016
- Author(s)
  Tsukumo Y, Alain T, Fonseca BD, Nadon R, Sonenberg N.
- Journal Title
  
  Nat Commun
  
  Volume: 7 Issue: 1 Pages: 11776-11776
- DOI
  10.1038/ncomms11776
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K18444
[Journal Article] Transcriptional induction of 4E-BP3 prolongs translation repression.2016
- Author(s)
  Tsukumo Y, Sonenberg N, Alain T.
- Journal Title
  
  Cell Cycle
  
  Volume: 15 Issue: 24 Pages: 3325-3326
- DOI
  10.1080/15384101.2016.1224786
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K18444
[Journal Article] Hyperactivation of 4E-binding protein 1 as a mediator of biguanide-induced cytotoxicity during glucose deprivation2012
- Author(s)
  Junichi Matsuo, Yoshinori Tsukumo (co-first), et al
- Journal Title
  
  Molecular Cancer Therapeutics
  
  Volume: 11 Pages: 1082-91
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22700892
[Journal Article] Hyperactivation of 4E-binding protein 1 as a mediator of biguanide-in duced cyto toxicity during glucose deprivation2012
- Author(s)
  Matsuo J, Tsukumo Y, Saito S, Tsukahara S, Sakurai J, Sato S, Kondo H, Ushijima M, Matsuura M, Watanabe T, Tomida A
- Journal Title
  
  Mol Cancer Ther
  
  Volume: 11(5) Issue: 5 Pages: 1082-1091
- DOI
  10.1158/1535-7163.mct-11-0871
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21300109, KAKENHI-PROJECT-22300342, KAKENHI-PROJECT-22700892, KAKENHI-PROJECT-24240042, KAKENHI-PROJECT-24650626
[Presentation] 緊急に使用許可された核酸増幅検査薬の性能評価試料に関する調査2023
- Author(s)
  築茂由則，井上貴雄
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-22K12899
[Presentation] パンデミック初期に緊急開発された核酸増幅検査薬の構成と性能評価に用いられた検体に関する調査2023
- Author(s)
  築茂由則，吉田徳幸，大岡伸通，内田恵理子，井上貴雄
- Organizer
  第30回日本遺伝子診療学会大会・第8回クリニカルバイオバンク学会シンポジウム合同学術集会
- Data Source
  KAKENHI-PROJECT-22K12899
[Presentation] COVID-19診断用核酸増幅検査薬の性能評価に用いられた検体に関する調査2023
- Author(s)
  築茂由則，井上貴雄
- Organizer
  第70回日本臨床検査医学会学術集会
- Data Source
  KAKENHI-PROJECT-22K12899
[Presentation] EGFR変異がんに対する新たな治療標的分子の同定2022
- Author(s)
  築茂由則, 大岡伸通, 内藤幹彦, 鈴木孝昌
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-22K12899
[Presentation] コンパニオン診断薬の開発状況と規制2022
- Author(s)
  築茂由則
- Organizer
  化学工学会第53回秋季大会
- Invited
- Data Source
  KAKENHI-PROJECT-19K07724
[Presentation] Performance evaluation of COVID-19 diagnostic nucleic acid amplification tests using purified SARS-CoV-2 genomic RNAs2022
- Author(s)
  Yoshinori Tsukumo, Tokuyuki Yoshida, Nobumichi Ohoka, Takayoshi Suzuki, Eriko Uchida, Takao Inoue
- Organizer
  The 17th Congress of Asian Society for Clinical Pathology and Laboratory Medicine
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K12899
[Presentation] コンパニオン診断薬の開発状況と規制2022
- Author(s)
  築茂由則
- Organizer
  化学工学会第53回秋季大会
- Invited
- Data Source
  KAKENHI-PROJECT-22K12899
[Presentation] Identification of protein X as a potential therapeutic target against EGFR-mutated cancers2022
- Author(s)
  Yoshinori Tsukumo, Nobumichi Ohoka, Mikihiko Naito, Takayoshi Suzuki
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K07724
[Presentation] 緊急開発されたCOVID-19診断用核酸増幅検査薬の構成に関する調査2022
- Author(s)
  築茂由則, 吉田徳幸, 大岡伸通, 内田恵理子, 鈴木孝昌, 井上貴雄
- Organizer
  第12回レギュラトリーサイエンス学会学術大会
- Data Source
  KAKENHI-PROJECT-22K12899
[Presentation] EGFR 変異陽性肺がんに対する新規治療標的分子の同定2021
- Author(s)
  築茂由則, 大岡伸通, 内藤幹彦, 鈴木孝昌
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K07724
[Presentation] Translational profiling of EGFR-mutated cancer cells2019
- Author(s)
  築茂由則、鈴木孝昌、内藤幹彦
- Organizer
  日本癌学会
- Data Source
  KAKENHI-PROJECT-19K07724
[Presentation] Establishment of EGFR L858R-knock-in cells using a genome editing technology and their EGFR-TKI sensitivity2017
- Author(s)
  築茂由則, 鈴木孝昌, 内藤幹彦
- Organizer
  日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16K18444
[Presentation] Hyper-activation of 4E-binding protein 1 by anti-diabetic biguanide as its anti-tumor mechanisms of action2011
- Author(s)
  Yoshinori Tsukumo, Junichi Matsuo, Satomi Tsukahara, Junko Sakurai, Toshiki Watanabe, Sigeo Sato, Hiromichi Kondo, and Akihiro Tomida
- Organizer
  American Association for Cancer Research, Special conference
- Place of Presentation
  サンフランシスコ
- Year and Date
  2011-02-26
- Data Source
  KAKENHI-PROJECT-22700892
[Presentation] Hyper-activation of 4E-binding protein 1 by anti-diabetic biguanide as its anti-tumor mechanisms of action2011
- Author(s)
  築茂由則
- Organizer
  American Association for Cancer Research, Special conference, "Targeting PI3K/mTOR signaling in cancer"
- Place of Presentation
  サンフランシスコ
- Year and Date
  2011-02-26
- Data Source
  KAKENHI-PROJECT-22700892
[Presentation] ビグアナイド系化合物による4E-BP1の活性化と抗腫瘍効果2011
- Author(s)
  築茂由則
- Organizer
  分子標的治療学会
- Place of Presentation
  東京ホテル日航東京
- Data Source
  KAKENHI-PROJECT-22700892
[Presentation] ビグアナイド系化合物による4E-BP1の活性化と抗腫瘍効果2011
- Author(s)
  築茂由則、近藤裕道、冨田章弘
- Organizer
  分指標的治療学会
- Place of Presentation
  東京
- Year and Date
  2011-06-23
- Data Source
  KAKENHI-PROJECT-22700892

1. HARA Toshihide

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. 出水庸介

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
3. 松浦正明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 牛嶋大

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 大岡伸通

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Tsukumo Yoshinori 築茂 由則

TSUKUMO Yosinori 築茂 由則

Research Projects

Research Products

Co-Researchers

核酸増幅検査薬の性能評価に用いる革新的試料の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

cell free mRNAからの微量遺伝子変異検出法の確立とその応用Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of novel therapeutic and diagnostic methods for EGFR-mutated lung cancersPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Screening of biomarkers to predict the drug efficacy based on translation profilingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Studies on selective translation mechanism of stress response Protein under global translational repressionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 次世代医薬とバイオ医療 第8章 個別化医療に向けた診断用医薬品 コンパニオン診断薬2022

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Current Status and Regulatory Issues of Companion Diagnostics in Japan2024

Author(s)

Journal Title

Data Source

[Journal Article] Survey and Consideration of the Composition of COVID-19 Diagnostic Nucleic Acid Amplification Tests Approved for Use in the Early Stage of COVID-19 Pandemic2023

Author(s)

Journal Title

DOI

ISSN

Language

Data Source

[Journal Article] Development of Gilteritinib-Based Chimeric Small Molecules that Potently Induce Degradation of FLT3-ITD Protein2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Development of a potent small-molecule degrader against oncogenic BRAFV600E protein that evades paradoxical MAPK activation.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Protocols for Synthesis of and the Methods to Evaluate the Anticancer Effects2021

Author(s)

Journal Title

DOI

ISBN

Data Source

[Journal Article] Influence of EGFR-activating mutations on sensitivity to tyrosine kinase inhibitors in a KRAS mutant non-small cell lung cancer cell line.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Preparation of the standard cell lines for reference mutations in cancer gene-panels by genome editing in HEK 293T/17 cells.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] eIF4A inhibition circumvents uncontrolled DNA replication mediated by 4E-BP1 loss in pancreatic cancer.2019

Author(s)

Journal Title

Tsukumo Yoshinori 築茂由則

TSUKUMO Yosinori 築茂由則

[Book] 次世代医薬とバイオ医療　第8章個別化医療に向けた診断用医薬品コンパニオン診断薬2022