SHIMIZU TADASHI 清水忠

… Alternative Names

Tadashi Shimizu 清水忠

SHIMIZU Tadashi 清水忠

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Researcher Number	40509022
Other IDs
Affiliation (Current)	2025: 兵庫医科大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help	2022 – 2024: 兵庫医科大学, 薬学部, 教授 2018 – 2021: 兵庫医療大学, 薬学部, 准教授 2016 – 2017: 兵庫医療大学, 薬学部, 講師 2009 – 2012: Hyogo University of Health Sciences, 薬学部, 助教 2008: Hyogo University of Health Sciences, 薬学部, 助手
Review Section/Research Field	Principal Investigator Basic Section 56010:Neurosurgery-related / Drug development chemistry / Tumor therapeutics Except Principal Investigator Basic Section 09070:Educational technology-related
Keywords	Principal Investigator ドラッグリポジショニング / 代謝物 / 光学分割 / 膠芽腫 / 探索合成 / ターゲット探索 / 構造活性相関 / DCP-LA / 生理活性脂肪酸 / 認知症治療剤 … More / 機械学習 / ビッグデータ / 新規誘導体 / 作用メカニズム / 細胞死 / ブロナンセリン / 抗がん活性 / 膀胱癌 / アフィニティ樹脂 / 塩酸塩 / 溶解性 / 悪性中皮腫 / in vio評価 / 薬物動態 / 膀胱がん / 中皮腫 / ナフトピジル / 認知症治療 / PKC-e / PKC-ε / 医薬品化学 / シクロプロパン / 光学活性誘導体 … More Except Principal Investigator 化学教育 / ゲーミフィケーション / メタアナリシス / 薬剤師 / 質的研究 / コミュニケーション能力 / コンピテンシー Less

臨床ビッグデータ情報と医薬品代謝物への構造変化を基軸した膠芽腫治療薬の創製Principal Investigator
- Principal Investigator
  
  清水忠
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Hyogo Medical University
薬学におけるゲーミフィケーションを活用した教育の電子アプリ化とその評価
- Principal Investigator
  
  青江麻衣
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 09070:Educational technology-related
- Research Institution
  Hyogo Medical University
薬剤師に求められるコンピテンシーへの到達を大学横断的に測定する
- Principal Investigator
  
  木下淳
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 09070:Educational technology-related
- Research Institution
  Hyogo Medical University
Development of therapeutic agents for glioblastoma based on the synthesis of bronanserin metabolites and new derivativesPrincipal Investigator
- Principal Investigator
  
  清水忠
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Hyogo Medical University
  Hyogo University of Health Sciences
Discovery of a novel naftopidil-based therapeutic agent for malignant mesothelioma and mechanism of actionPrincipal Investigator
- Principal Investigator
  
  Tadashi Shimizu
- Project Period (FY)
  2016 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor therapeutics
- Research Institution
  Hyogo Medical University
  Hyogo University of Health Sciences
Development and mechanistic study of novel anti- Alzheimer's disease drugs with PKC-ε selective activationPrincipal Investigator
- Principal Investigator
  
  SHIMIZU Tadashi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  Hyogo University of Health Sciences
Development and mechanistic study of novel anti-Alzheimer's disease drugs based on physiologically active fatty acidPrincipal Investigator
- Principal Investigator
  
  SHIMIZU Tadashi
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (Start-up)
- Research Field
  
  Drug development chemistry
- Research Institution
  Hyogo University of Health Sciences

All 2023 2020 2019 2018 2017 2016 2013 2012 2011 2010 2009

All Journal Article Presentation

[Journal Article] Effect of blonanserin on the proliferation and migration of glioblastoma cells2023
- Author(s)
  N. Tsuchiya, K. Okamoto, S. Nakao, S. Ohmori, T. Shimizu
- Journal Title
  
  Pharmazie
  
  Volume: 78
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K09142
[Journal Article] Identification of HUHS190, a human naftopidil metabolite, as a novel anti-bladder cancer drug2020
- Author(s)
  T. Shimizu, K. Yamaguchi, M Yamamoto, R. Kurioka, Y. Kino, W. Matsunaga, S. Nakao, H.Fukuhara, A. Tanaka, A. Gotoh, M. Mabuchi
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 30 Pages: 126744-126744
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K07186
[Journal Article] Development of a Water-Soluble Indolylmaleimide Derivative IM-93 Showing Dual Inhibition of Ferroptosis and NETosis.2019
- Author(s)
  K. Dodo, E*. Kuboki*, T Shimizu* (*equally contributed first author), R. Imamura, M. Magarisawa, M. Takahashi, T. Tokuhiro, S. Yasumoto, K. Asano, S. Nakao, N. Terayama, T.Suda, M. Tanaka, M. Sodeoka.
- Journal Title
  
  ACS Med Chem Lett.
  
  Volume: 10 Issue: 9 Pages: 1272-1278
- DOI
  10.1021/acsmedchemlett.9b00142
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K07186, KAKENHI-PROJECT-17H04068, KAKENHI-PROJECT-19K08894
[Journal Article] Indolylmaleimide Derivative IM-17 Shows Cardioprotective Effects in Ischemia-Reperfusion Injury.2018
- Author(s)
  Dodo K, Shimizu T, Sasamori J, Aihara K, Terayama N, Nakao S, Iuchi K, Takahashi M, Sodeoka M.
- Journal Title
  
  ACS Med Chem Lett.
  
  Volume: 9 Issue: 3 Pages: 182-187
- DOI
  10.1021/acsmedchemlett.7b00454
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K07186, KAKENHI-PLANNED-26110004
[Journal Article] Novel Metabolically Stable PCA-1/ALKBH3 Inhibitor Has Potent Antiproliferative Effects on DU145 Cells In Vivo.2018
- Author(s)
  Ueda M, Shimizu T, Mabuchi M, Horiike K, Kitae K, Hase H, Ueda Y, Tsujikawa K, Tanaka A
- Journal Title
  
  Anticancer Res.
  
  Volume: 38 Issue: 1 Pages: 211-218
- DOI
  10.21873/anticanres.12210
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K07186, KAKENHI-PROJECT-15K08036
[Journal Article] Synthesis of resveratrol derivatives as new analgesic drugs through desensitization of the TRPA1 receptor.2017
- Author(s)
  Nakao S, Mabuchi M, Wang S, Kogure Y, Shimizu T, Noguchi K, Tanaka A, Dai Y.
- Journal Title
  
  Bioorg Med Chem Lett.
  
  Volume: 27 Issue: 14 Pages: 3167-3172
- DOI
  10.1016/j.bmcl.2017.05.025
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K07186
[Journal Article] Systematic Trial for Evaluating Docetaxel in a Human Prostate Cancer Cell DU145 Xenograft Model2017
- Author(s)
  MIYUKI MABUCHI, MASAHIRO UEDA, YURI YOSHIDA, KOTA HORIIKE, KENTA YAMAOKA, SYUHEI NAKAO, TADASHI SHIMIZU, YUKO UEDA, KAZUTAKE TSUJIKAWA, AKITO TANAKA
- Journal Title
  
  anticancer research
  
  Volume: 37 Issue: 4 Pages: 1665-1676
- DOI
  10.21873/anticanres.11496
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460164, KAKENHI-PROJECT-15K08036, KAKENHI-PROJECT-16K07186
[Journal Article] Structure–Activity Relationship Study of 3-Amino-2-indolyllactam Derivatives: Development of Inhibitors of Oxidative Stress-Induced Necrosis2016
- Author(s)
  Kosuke Dodo, Kenji Hayamizu, Tadashi Shimizu, Mikko Sodeoka
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 64 Issue: 7 Pages: 886-898
- DOI
  10.1248/cpb.c16-00259
- NAID
  130005160020
- ISSN
  0009-2363, 1347-5223
- Language
  English
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-26110004, KAKENHI-PROJECT-16K07186
[Journal Article] The phosphatidylethanolamine derivative diDCP-LA-PE mimics intracellular insulin signaling.2016
- Author(s)
  T. Nishizaki, A. Gotoh, T.Shimizu, A. Tanaka
- Journal Title
  
  Sci.Rep.
  
  Volume: 6 Issue: 1
- DOI
  10.1038/srep27267
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K07186
[Journal Article] Regulation of GluA1 AMPA Receptor throughPKC Phosphorylation Induced by Free Fatty Acid Derivative HUHS2002.2013
- Author(s)
  T. Nishimoto, T. Kanno, T. Shimizu, A. Tanaka, T. Nishizaki
- Journal Title
  
  Lipids
  
  Volume: 43 Pages: 23-28
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790120
[Journal Article] Effects of Newly Synthesized DCP-LA-Phospholipids on Protein Kinase C and Protein Phosphatases.2013
- Author(s)
  T. Kanno, A. Tsuchiya, T.Shimizu, S. Nakao, A. Tanaka, T. Nishizaki
- Journal Title
  
  Cell.Physiol. Biochem.
  
  Volume: 31 Pages: 555-564
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790120
[Journal Article] Synthetic Route to Optically Pure Norcantharidin Analog NCA-01, a Highly Selective Protein Phosphatase 2B inhibitor, and Its Derivatives2012
- Author(s)
  Tadashi Shimizu
- Journal Title
  
  Chemistry-An Asian Journal
  
  Volume: (Published online) Issue: 6 Pages: 1221-1230
- DOI
  10.1002/asia.201200077
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790120
[Journal Article] 8-[2-(2-Pentyl-Cyclopropylmethyl)-Cyclopropyl]-Octanoic Acid and Its DIastereomers Improve Age-Related Cognitive Deteriotation.2012
- Author(s)
  T. Kanno, T. Yaguchi, T. Shimizu, A. Tanaka, T. Nishizaki
- Journal Title
  
  Lipids
  
  Volume: 47 Pages: 687-695
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790120
[Journal Article] Novel Indomethacin Action: Selective and DirectActivation of Protein Kinase C-ε2012
- Author(s)
  T. Kanno, A. Tsuchiya, T. Shimizu, A. Tanaka, T. Nishizaki
- Journal Title
  
  Cell. Physiol. Biochem.
  
  Volume: 30 Pages: 771-777
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790120
[Journal Article] Synthetic Route to Optically Pure NorcantharidinAnalog NCA-01, a Highly Selective Protein Phosphatase 2B inhibitor, and Its Derivatives.2012
- Author(s)
  T. Shimizu, M. Iizuka, H. Matsukura, D. Hashizume, M. Sodeoka
- Journal Title
  
  Chem. Asian J.
  
  Volume: 7 Pages: 1221-1230
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790120
[Journal Article] Indomethacin Serves as a Potential Inhibitor ofProtein Phosphatases.2012
- Author(s)
  T. Kanno, A. Tsuchiya, T. Shimizu, A. Tanaka, T. Nishizaki
- Journal Title
  
  Cell. Physiol. Biochem.
  
  Volume: 30 Pages: 1014-1022
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790120
[Journal Article] Free Fatty Acid Derivative HUHS2002Potentiates α7 ACh Receptor Responces Through Indirect Activation of CaMKII.2012
- Author(s)
  T. Kanno, T. Shimizu, A. Tanaka, T. Nishimoto, T. Nishizaki
- Journal Title
  
  Lipids
  
  Volume: 49 Pages: 865-871
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790120
[Journal Article] Indomethacin Enhances Learning and Memory Potential by Interacting with CaMKII.2012
- Author(s)
  T. Kanno, T. Yaguchi, T. Nagata, T. Shimizu, A. Tanaka, T. Nishizaki
- Journal Title
  
  J. Cell Physiol.
  
  Volume: 227 Pages: 919-926
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790120
[Journal Article] α, β-DCP-LA Selectivity Activates PKC-ε andStimulates Neurotransmitter Release with the Highest Potency among 4 Diastereomers.2011
- Author(s)
  T. Shimizu, T. Kanno, A. Tanaka, T. Nishizaki
- Journal Title
  
  Cell. Physiol. Biochem.
  
  Volume: 27 Pages: 149-158
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790120
[Journal Article] α,β-DCP-LA Selectivity Activates PKC-ε and Stimulates Neurotransmitter Release with the Highest Potency among 4 Diastereomers2011
- Author(s)
  Tadashi Shimizu
- Journal Title
  
  Cellular Physiology and Biochemistry
  
  Volume: 27 Pages: 149-158
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790120
[Journal Article] Formal [6+4] cycloaddition of a dicobaltacetylene complex with furan derivatives.2011
- Author(s)
  K. Dota, T. Shimizu, S. Hasegawa, M. Miyashia, K. Tanino
- Journal Title
  
  Tetrahedron Lett.
  
  Volume: 52 Pages: 910-912
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790120
[Journal Article] Cyclooctanone synthesis via a formal [6+2] cycloaddition reaction of a dicobalt acetylene complex.2010
- Author(s)
  K. Mitachi, T. Shimizu, M. Miyashita, K. Tanino
- Journal Title
  
  Teterahedron Lett.
  
  Volume: 51 Pages: 3983-3986
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790120
[Journal Article] Total synthesis of furanether B. Construction of a hydroazulene skeleton via a novel [5 + 2] cycloaddition reaction of silyloxyallene.2010
- Author(s)
  K. Mitachi, T. Yamamoto, F. Kondo, T. Shimizu, M. Miyashita, K. Tanino
- Journal Title
  
  Chem. Lett.
  
  Volume: 39 Pages: 630-632
- NAID
  10027181753
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790120
[Journal Article] Selective elution of target protein from affinityresins by a simple reductant with a thiol group.2010
- Author(s)
  M. Mabuchi, M. Haramura, T. Shimizu, T. Nishizaki, A. Tanaka
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 20 Pages: 7361-7364
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790120
[Journal Article] Asymmetric synthesis of isobenzo furanone derivatives and their unique character as protein kinase Cα(PKCα).2009
- Author(s)
  G. Hirai, Y. Ogoshi, M. Ohkubo, Y. Tamura, T. Watanabe, T. Shimizu, M. Sodeoka
- Journal Title
  
  Teterahedron Lett. 50
  
  Pages: 3609-3612
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20890266
[Journal Article] Improvement of monolithic solid material by utilization of spacer for identification of the target using affinity resins2009
- Author(s)
  E. Iwaoka, T. Mori, T. Shimizu, K. Hosoya, A. Tanaka
- Journal Title
  
  Med. Chem. Lett. 19
  
  Pages: 1469-1472
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20890266
[Presentation] ブロナンセリン主要代謝物の膠芽腫に対する抗癌活性の評価2023
- Author(s)
  岡本兼弥、土屋菜摘、森山雅月、中尾周平、馬渕美雪、清水忠
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-21K09142
[Presentation] 「臨床応用」を志向した創薬研究～大学発の創薬を目指して～2016
- Author(s)
  清水　忠
- Organizer
  第2回近畿薬学シンポジウム・化学系の若い力
- Place of Presentation
  大阪大学薬学研究科1号館4階沢井ホール（大阪府吹田市）
- Year and Date
  2016-06-04
- Invited
- Data Source
  KAKENHI-PROJECT-16K07186
[Presentation] Synthesis and Evaluation of optically active DCP-LA as a PKC-ε selective activator2011
- Author(s)
  Tadashi Shimizu
- Organizer
  8th AFMC Internatonal Medicinal Chemistry Symposium
- Place of Presentation
  東京
- Year and Date
  2011-12-01
- Data Source
  KAKENHI-PROJECT-22790120
[Presentation] Synthesis and Evaluation of optically active DCP-LA as a PKC-ε selective activator (Oral presentation).2011
- Author(s)
  T. Shimizu, M. Mabuchi, T. Kanno,T. Nishizaki, A. Tanaka
- Organizer
  8th AFMC International Medicinal Chemistry Symposium
- Place of Presentation
  Tokyo
- Year and Date
  2011-12-01
- Data Source
  KAKENHI-PROJECT-22790120

1. 篠山隆司 (10379399)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. 中尾周平 (90868605)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
3. 上田昌宏 (80846353)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. 長屋寿雄 (60464343)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 大野喜也 (40509155)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 大森志保 (90379488)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. 木下淳 (60454766)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 安原智久 (20351570)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 永田実沙 (70910553)

# of Collaborated Projects: 1 results

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10. 串畑太郎 (70736842)

# of Collaborated Projects: 1 results

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11. 矢原恵美 (70929728)

# of Collaborated Projects: 1 results

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12. 高良恒史 (00329939)

# of Collaborated Projects: 1 results

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13. 所美雪 (60714897)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
14. 長野秀嗣 (31003494)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 青江麻衣 (40794805)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 江崎誠治 (50454400)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 松野純男 (30299094)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. AKITO Tanaka

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 辻川和丈

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

SHIMIZU TADASHI 清水 忠

Tadashi Shimizu 清水 忠

SHIMIZU Tadashi 清水 忠

Research Projects

Research Products

Co-Researchers

臨床ビッグデータ情報と医薬品代謝物への構造変化を基軸した膠芽腫治療薬の創製Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

薬学におけるゲーミフィケーションを活用した教育の電子アプリ化とその評価

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

薬剤師に求められるコンピテンシーへの到達を大学横断的に測定する

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of therapeutic agents for glioblastoma based on the synthesis of bronanserin metabolites and new derivativesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Discovery of a novel naftopidil-based therapeutic agent for malignant mesothelioma and mechanism of actionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development and mechanistic study of novel anti- Alzheimer's disease drugs with PKC-ε selective activationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development and mechanistic study of novel anti-Alzheimer's disease drugs based on physiologically active fatty acidPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Effect of blonanserin on the proliferation and migration of glioblastoma cells2023

Author(s)

Journal Title

Data Source

[Journal Article] Identification of HUHS190, a human naftopidil metabolite, as a novel anti-bladder cancer drug2020

Author(s)

Journal Title

Data Source

[Journal Article] Development of a Water-Soluble Indolylmaleimide Derivative IM-93 Showing Dual Inhibition of Ferroptosis and NETosis.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Indolylmaleimide Derivative IM-17 Shows Cardioprotective Effects in Ischemia-Reperfusion Injury.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Novel Metabolically Stable PCA-1/ALKBH3 Inhibitor Has Potent Antiproliferative Effects on DU145 Cells In Vivo.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Synthesis of resveratrol derivatives as new analgesic drugs through desensitization of the TRPA1 receptor.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Systematic Trial for Evaluating Docetaxel in a Human Prostate Cancer Cell DU145 Xenograft Model2017

Author(s)

Journal Title

DOI

SHIMIZU TADASHI 清水忠

Tadashi Shimizu 清水忠

SHIMIZU Tadashi 清水忠