Konno Ayumu 今野歩

… Alternative Names

KONNO Ayumu 今野歩

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Researcher Number	40509048
Other IDs	https://orcid.org/0000-0001-9382-396X
Affiliation (Current)	2025: 群馬大学, 大学院医学系研究科, 講師
Affiliation (based on the past Project Information) *help	2016 – 2024: 群馬大学, 大学院医学系研究科, 講師 2012 – 2015: 群馬大学, 医学(系)研究科(研究院), 助教 2014: 群馬大学, 大学院医学系研究科, 助教
Review Section/Research Field	Principal Investigator Basic Section 46020:Anatomy and histopathology of nervous system-related / Transformative Research Areas, Section (III) / Basic Section 46010:Neuroscience-general-related / Neurophysiology / General neuroscience / Neurophysiology and muscle physiology Except Principal Investigator Basic Section 51030:Pathophysiologic neuroscience-related / Neurophysiology / General neuroscience / Medium-sized Section 10:Psychology and related fields / Basic Section 62010:Life, health and medical informatics-related / Basic Section 59020:Sports sciences-related … More / Basic Section 38050:Food sciences-related / Basic Section 54040:Metabolism and endocrinology-related / Neurology / Basic / Social brain science / Neurochemistry/Neuropharmacology Less
Keywords	Principal Investigator AAVベクター / ウイルスベクター / 血液脳関門 / アデノ随伴ウイルスベクター / 遺伝子治療 / コンディショナルノックアウト / Cre-loxP / シナプス結合 / 神経回路 / AAV2-BR1N … More / 中和抗体 / AAV / 脊髄小脳失調症 / ゲノム編集 / CRISPR/Cas9 / 抗体 / 小脳 … More Except Principal Investigator 小脳 / AAV / 神経科学 / プルキンエ細胞 / 強化学習 / アルツハイマー病 / オペラント条件付け / 依存症 / 大脳基底核 / 遺伝子治療 / 遺伝子 / 脳神経疾患 / SCA1 / AAVベクター / 脊髄小脳失調症 / 大脳皮質 / グリア / 脊髄小脳変性症 / 神経変性疾患 / ドーパミン / 行動嗜癖 / 確定演出 / microRNA / 遺伝子発現 / マウス / カプシド / Iba1 / 血液脳関門 / ミクログリア / 学習率 / k本腕バンディット課題 / 海馬 / エクソソーム / miRNA / 運動 / ２型糖尿病 / APOE / 摂食行動 / 線条体 / 過食 / 摂食障害 / エンケファリン / 視床下部 / 肥満 / 自然免疫 / 炎症 / 再生医学 / アデノ随伴ウイルスベクター / ウイルスベクター / ゲノム編集 / CRISPR/Cas9 / 細胞種特異的プロモーター / パッチクランプ / ロータロッド / ポリグルタミン病 / 生理学 / シグナル伝達 / 運動記憶 / SCA3 / 運動失調 / バクロフェン / 運動学習 / mGluR1 / ATP受容体 / 二重感染 / 脳・神経 / カルシウム / ニューロピル / ニューロングリア相互作用 / イメージング / 神経細胞 / アストロサイト / グリア細胞 / シナプス伝達 / 神経変性症 / NMDA受容体 / メマンチン / 脊髄小脳変性症1型 Less

APOE2がもつ神経保護作用を利用したアルツハイマー病の病態制御
- Principal Investigator
  
  山崎雄
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Hiroshima University
The effects of exercise on hippocampal dysfunction in type 2 diabetes through multi-organ crosstalk
- Principal Investigator
  
  島孟留
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59020:Sports sciences-related
- Research Institution
  Gunma University
強化学習ハイパーパラメータの脳制御機構の解明
- Principal Investigator
  
  太田宏之
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 62010:Life, health and medical informatics-related
- Research Institution
  National Defense Medical College
Development of highly efficient trans-synaptic AAV vector mutantsPrincipal Investigator
- Principal Investigator
  
  今野歩
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  Gunma University
予測行動学の創成：可予測性が引き起こすプロセス依存形成ダイナミクスの解明
- Principal Investigator
  
  太田宏之
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 10:Psychology and related fields
- Research Institution
  National Defense Medical College
Development of microglia-targeting AAV vectors and its application to neurodegenerative disorders
- Principal Investigator
  
  平井宏和
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Gunma University
視床下部炎症を誘導する自然免疫シグナル経路の解析：摂食調節異常機構の解明
- Principal Investigator
  
  渡邉康春
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Toyama Prefectural Institute for Pharmaceutical Research
AAVベクターの静脈投与のみでコンディショナルノックアウトを行う手法の開発Principal Investigator
- Principal Investigator
  
  今野歩
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 46020:Anatomy and histopathology of nervous system-related
- Research Institution
  Gunma University
脳内オピオイド産生の計測制御による過食のメカニズムの解明
- Principal Investigator
  
  太田宏之
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 38050:Food sciences-related
- Research Institution
  National Defense Medical College
Development of a technique that allows repeatable gene transfer into the brain using AAV vectorsPrincipal Investigator
- Principal Investigator
  
  Konno Ayumu
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 46010:Neuroscience-general-related
- Research Institution
  Gunma University
Cortical circuit plasticity supported by glia
- Principal Investigator
  
  Hirase Hajime
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Basic / Social brain science
- Research Institution
  Institute of Physical and Chemical Research
Development of gene therapy against neurodegenerative diseases using CRISPR/Cas9-based genome editing
- Principal Investigator
  
  Hirai Hirokazu
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Neurology
- Research Institution
  Gunma University
Development of a novel gene therapy method via CRISPR/Cas9 mediated in vivo genome editingPrincipal Investigator
- Principal Investigator
  
  Konno Ayumu
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurophysiology / General neuroscience
- Research Institution
  Gunma University
Elucidation of cellular and nuclear signals that regulate motor learning
- Principal Investigator
  
  Hirai Hirokazu
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurophysiology / General neuroscience
- Research Institution
  Gunma University
Long-term oral administration of the NMDA receptor antagonist memantine extends life span in spinocerebellar ataxia type 1 knock-in mice.
- Principal Investigator
  
  IIZUKA Akira
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Gunma University
Functional roles of glial ATP receptors in neuron-glia interaction
- Principal Investigator
  
  HOSOI Nobutake
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurophysiology / General neuroscience
- Research Institution
  Gunma University
Selective transduction into parallel fiber or climbing fiber using antibody-displaying viral vectorPrincipal Investigator
- Principal Investigator
  
  KONNO Ayumu
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurophysiology and muscle physiology
- Research Institution
  Gunma University

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All Journal Article Presentation Book Patent

[Book] ２章ウイルスベクターを用いた遺伝子導入プロトコール：６－静脈投与によるマウス脳全域への遺伝子導入 in 「決定版　ウイルスベクターによる遺伝子導入実験ガイド」2020
- Author(s)
  今野歩（平井　宏和、日置　寛之、小林　和人編集)
- Total Pages
  285
- Publisher
  羊土社
- ISBN
  9784758122474
- Data Source
  KAKENHI-PROJECT-19K06899
[Book] １章各ウイルスベクターの特徴と作製の基本：２－AAVベクター in 「決定版　ウイルスベクターによる遺伝子導入実験ガイド」2020
- Author(s)
  今野歩（平井　宏和、日置　寛之、小林　和人編集)
- Total Pages
  285
- Publisher
  羊土社
- ISBN
  9784758122474
- Data Source
  KAKENHI-PROJECT-19K06899
[Journal Article] Protein kinase Cγ negatively regulates the intrinsic excitability in zebrin-negative cerebellar Purkinje cells2024
- Author(s)
  Masashi Watanave, Mika Kawachi, Ayumu Konno, Ryo Aoki, Yuuki Fukai, Yasunori Matsuzaki, Ryosuke Kaneko, Hirokazu Hirai
- Journal Title
  
  Frontiers in Cellular Neuroscience
  
  Volume: 18 Pages: 1-12
- DOI
  10.3389/fncel.2024.1349878
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15365, KAKENHI-PROJECT-22K06454, KAKENHI-PROJECT-22K06457
[Journal Article] Anxiety control by astrocytes in the lateral habenula2024
- Author(s)
  Tan Wanqin、Ikoma Yoko、Takahashi Yusuke、Konno Ayumu、Hirai Hirokazu、Hirase Hajime、Matsui Ko
- Journal Title
  
  Neuroscience Research
  
  Volume: - Pages: 1-15
- DOI
  10.1016/j.neures.2024.01.006
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K06454, KAKENHI-PROJECT-22K15218, KAKENHI-PLANNED-20H05896, KAKENHI-PUBLICLY-23H04659, KAKENHI-PROJECT-23K23976
[Journal Article] Improving cell-specific recombination using AAV vectors in the murine CNS by capsid and expression cassette optimization2024
- Author(s)
  Kawabata Hayato、Konno Ayumu、Matsuzaki Yasunori、Sato Yumika、Kawachi Mika、Aoki Ryo、Tsutsumi Saki、Togai Shota、Kobayashi Ryosuke、Horii Takuro、Hatada Izuho、Hirai Hirokazu
- Journal Title
  
  Molecular Therapy - Methods & Clinical Development
  
  Volume: 32 Issue: 1 Pages: 101185-101185
- DOI
  10.1016/j.omtm.2024.101185
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06454, KAKENHI-PROJECT-23K27482
[Journal Article] Excitatory subtypes of the lateral amygdala neurons are differentially involved in regulation of synaptic plasticity and excitation/inhibition balance in aversive learning in mice2023
- Author(s)
  Morishima Mieko、Matsumura Sohta、Tohyama Suguru、Nagashima Takashi、Konno Ayumu、Hirai Hirokazu、Watabe Ayako M.
- Journal Title
  
  Frontiers in Cellular Neuroscience
  
  Volume: 17 Pages: 1-14
- DOI
  10.3389/fncel.2023.1292822
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06454, KAKENHI-PROJECT-21K07265, KAKENHI-PROJECT-21K16374, KAKENHI-PLANNED-22H05162, KAKENHI-PROJECT-23K24799
[Journal Article] Astrocytic GPCR-Induced Ca2+ Signaling Is Not Causally Related to Local Cerebral Blood Flow Changes2023
- Author(s)
  Ozawa Katsuya、Nagao Masaki、Konno Ayumu、Iwai Youichi、Vittani Marta、Kusk Peter、Mishima Tsuneko、Hirai Hirokazu、Nedergaard Maiken、Hirase Hajime
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 24 Issue: 17 Pages: 13590-13590
- DOI
  10.3390/ijms241713590
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K06454
[Journal Article] A blood-brain barrier-penetrating AAV2 mutant created by a brain microvasculature endothelial cell-targeted AAV2 variant2023
- Author(s)
  Kawabata Hayato、Konno Ayumu、Matsuzaki Yasunori、Hirai Hirokazu
- Journal Title
  
  Molecular Therapy - Methods & Clinical Development
  
  Volume: 29 Pages: 81-92
- DOI
  10.1016/j.omtm.2023.02.016
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K06899, KAKENHI-PROJECT-22K06454
[Journal Article] Dynamic modulation of pulsatile activities of oxytocin neurons in lactating wild-type mice2023
- Author(s)
  Yaguchi Kasane、Hagihara Mitsue、Konno Ayumu、Hirai Hirokazu、Yukinaga Hiroko、Miyamichi Kazunari
- Journal Title
  
  PLOS ONE
  
  Volume: 18 Issue: 5 Pages: e0285589-e0285589
- DOI
  10.1371/journal.pone.0285589
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06454, KAKENHI-PROJECT-23K08796, KAKENHI-PROJECT-20K20589, KAKENHI-PLANNED-23H04945
[Journal Article] State-dependent modulation of positive and negative affective valences by a parabrachial nucleus-to-ventral tegmental area pathway in mice2023
- Author(s)
  Nagashima Takashi、Mikami Kaori、Tohyama Suguru、Konno Ayumu、Hirai Hirokazu、Watabe Ayako M.
- Journal Title
  
  Frontiers in Neural Circuits
  
  Volume: 17 Pages: 1-10
- DOI
  10.3389/fncir.2023.1273322
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06454, KAKENHI-PROJECT-21K16374, KAKENHI-PROJECT-23K24799
[Journal Article] Interstitial-fluid shear stresses induced by vertically oscillating head motion lower blood pressure in hypertensive rats and humans2023
- Author(s)
  Murase Shuhei、Sakitani Naoyoshi、Maekawa Takahiro、Yoshino Daisuke、Takano Kouji、Konno Ayumu、Hirai Hirokazu、Saito Taku、et al
- Journal Title
  
  Nature Biomedical Engineering
  
  Volume: 7 Issue: 11 Pages: 1350-1373
- DOI
  10.1038/s41551-023-01061-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K18325, KAKENHI-PROJECT-23K16632, KAKENHI-PROJECT-22K06454, KAKENHI-PROJECT-21K11330, KAKENHI-PROJECT-21K19552, KAKENHI-PROJECT-22K19761, KAKENHI-PROJECT-21H04688, KAKENHI-PROJECT-21H04866, KAKENHI-PROJECT-23K24467, KAKENHI-PROJECT-23K27718, KAKENHI-PROJECT-23K27906
[Journal Article] Protective roles of MITOL against myocardial senescence and ischemic injury partly via Drp1 regulation2022
- Author(s)
  Tokuyama T、Uosaki H、Sugiura A、Nishitai G、Takeda K、Nagashima S、Shiiba I、Ito N、Amo T、Mohri S、Nishimura A、Nishida M、Konno A、Hirai H、Ishido S、Yoshizawa T、Shindo T、Takada S、Kinugawa S、Inatome R、Yanagi S
- Journal Title
  
  iScience
  
  Volume: 25 Issue: 7 Pages: 104582-104582
- DOI
  10.1016/j.isci.2022.104582
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07878, KAKENHI-PROJECT-21K06844, KAKENHI-PROJECT-22K19754, KAKENHI-PROJECT-22K15399, KAKENHI-PROJECT-19KK0219, KAKENHI-PLANNED-21H05269, KAKENHI-PUBLICLY-22H05574, KAKENHI-PROJECT-18H05293, KAKENHI-PROJECT-20H03454, KAKENHI-PROJECT-21H03360, KAKENHI-PROJECT-19K06899, KAKENHI-PROJECT-19K22791, KAKENHI-PROJECT-23K24334, KAKENHI-PROJECT-22K06454
[Journal Article] DOPAnization of tyrosine in α-synuclein by tyrosine hydroxylase leads to the formation of oligomers.2022
- Author(s)
  1.Jin M., Matsumoto S., Ayaki T., Yamakado H., Taguchi T., Togawa N., Konno A., Hirai H., Nakajima H., Komai S., Ishida R., Chiba S., Takahashi R., Takao T. and Hirotsune S.
- Journal Title
  
  Nature Communications
  
  Volume: 13(1):6880 Issue: 1 Pages: 6880-6880
- DOI
  10.1038/s41467-022-34555-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06821, KAKENHI-PROJECT-22K06207, KAKENHI-PROJECT-22K06887, KAKENHI-PROJECT-22H04922, KAKENHI-PROJECT-19K06899, KAKENHI-PROJECT-19K16277, KAKENHI-PROJECT-22K06454
[Journal Article] Protein kinase Cγ in cerebellar Purkinje cells regulates Ca 2+-activated large-conductance K + channels and motor coordination2022
- Author(s)
  Watanave M, Takahashi N, Hosoi N, Konno A, Yamamoto H, Yasui H, Kawachi M, Horii T, Matsuzaki Y, Hatada I, Hirai H.
- Journal Title
  
  Proc Natl Acad Sci U S A
  
  Volume: 119(7) Issue: 7
- DOI
  10.1073/pnas.2113336119
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07103, KAKENHI-PROJECT-19K06899, KAKENHI-PROJECT-20K06906
[Journal Article] Plasticity of neural connections underlying oxytocin-mediated parental behaviors of male mice2022
- Author(s)
  Kengo Inada, Mitsue Hagihara, Kazuko Tsujimoto, Takaya Abe, Ayumu Konno, Hirokazu Hirai, Hiroshi Kiyonari, Kazunari Miyamichi
- Journal Title
  
  Neuron
  
  Volume: - Issue: 12 Pages: 2009-2023
- DOI
  10.1016/j.neuron.2022.03.033
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16303, KAKENHI-PROJECT-20K20589, KAKENHI-PROJECT-19K06899, KAKENHI-PROJECT-23K21349, KAKENHI-PROJECT-22K06454
[Journal Article] D-Cysteine Activates Chaperone-Mediated Autophagy in Cerebellar Purkinje Cells via the Generation of Hydrogen Sulfide and Nrf2 Activation2022
- Author(s)
  Ueda Erika、Ohta Tomoko、Konno Ayumu、Hirai Hirokazu、Kurauchi Yuki、Katsuki Hiroshi、Seki Takahiro
- Journal Title
  
  Cells
  
  Volume: 11 Issue: 7 Pages: 1230-1230
- DOI
  10.3390/cells11071230
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06631, KAKENHI-PROJECT-20H04126, KAKENHI-PROJECT-19K06899, KAKENHI-PROJECT-22K06454
[Journal Article] Liver-secreted fluorescent blood plasma markers enable chronic imaging of the microcirculation2022
- Author(s)
  Wang Xiaowen、Delle Christine、Asiminas Antonis、Akther Sonam、Vittani Marta、Br?gger Peter、Kusk Peter、Vo Camilla Trang、Radovanovic Tessa、Konno Ayumu、Hirai Hirokazu、Fukuda Masahiro、Weikop Pia、Goldman Steven A.、Nedergaard Maiken、Hirase Hajime
- Journal Title
  
  Cell Reports Methods
  
  Volume: 2 Issue: 10 Pages: 100302-100302
- DOI
  10.1016/j.crmeth.2022.100302
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06899, KAKENHI-PROJECT-22K06454
[Journal Article] Electrophysiological and Imaging Analysis of GFP-Tagged Protein Kinase C γ Translocation in Cerebellar Purkinje Cells2022
- Author(s)
  Hirai H, Fukai Y, Konno A, Hosoi N.
- Journal Title
  
  Cerebellum
  
  Volume: - Issue: 5 Pages: 776-783
- DOI
  10.1007/s12311-022-01384-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K07103, KAKENHI-PROJECT-20K06906, KAKENHI-PROJECT-19K06899, KAKENHI-PROJECT-22K06454
[Journal Article] A cortical cell ensemble in the posterior parietal cortex controls past experience-dependent memory updating2022
- Author(s)
  Suzuki Akinobu、Kosugi Sakurako、Murayama Emi、Sasakawa Eri、Ohkawa Noriaki、Konno Ayumu、Hirai Hirokazu、Inokuchi Kaoru
- Journal Title
  
  Nature Communications
  
  Volume: 13 Issue: 1 Pages: 41-41
- DOI
  10.1038/s41467-021-27763-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H05213, KAKENHI-PROJECT-19K06899
[Journal Article] Development of microglia-targeting adeno-associated viral vectors as tools to study microglial behavior in vivo2022
- Author(s)
  Okada Yukihiro、Hosoi Nobutake、Matsuzaki Yasunori、Fukai Yuuki、Hiraga Akito、Nakai Junichi、Nitta Keisuke、Shinohara Yoichiro、Konno Ayumu、Hirai Hirokazu
- Journal Title
  
  Communications Biology
  
  Volume: 5 Issue: 1 Pages: 1224-1224
- DOI
  10.1038/s42003-022-04200-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K06906, KAKENHI-PROJECT-19K06899, KAKENHI-PROJECT-22K06454
[Journal Article] Comparative study of neuron-specific promoters in mouse brain transduced by intravenously administered AAV-PHP.eB2021
- Author(s)
  Radhiyanti Putri T.、Konno Ayumu、Matsuzaki Yasunori、Hirai Hirokazu
- Journal Title
  
  Neuroscience Letters
  
  Volume: 756 Pages: 135956-135956
- DOI
  10.1016/j.neulet.2021.135956
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K06899
[Journal Article] GABAergic neuron-specific whole-brain transduction by AAV-PHP.B incorporated with a new GAD65 promoter2021
- Author(s)
  Hoshino Chiaki、Konno Ayumu、Hosoi Nobutake、Kaneko Ryosuke、Mukai Ryo、Nakai Junichi、Hirai Hirokazu
- Journal Title
  
  Molecular Brain
  
  Volume: 14 Issue: 1 Pages: 1-18
- DOI
  10.1186/s13041-021-00746-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07103, KAKENHI-PROJECT-20K06906, KAKENHI-PROJECT-18H02521, KAKENHI-PROJECT-19K06899, KAKENHI-PUBLICLY-19H04895, KAKENHI-PROJECT-20H02932, KAKENHI-PROJECT-16H06276
[Journal Article] The Ser19Stop single nucleotide polymorphism (SNP) of human PHYHIPL affects the cerebellum in mice.2021
- Author(s)
  Hisako Sugimoto, Takuro Horii, Jun-Na Hirota, Yoshitake Sano, Yo Shinoda, Ayumu Konno, Hirokazu Hirai, Yasuki Ishizaki, Hajime Hirase, Izuho Hatada, Teiichi Furuichi, Tetsushi Sadakata.
- Journal Title
  
  Molecular Brain
  
  Volume: 52 Issue: 1 Pages: 1-9
- DOI
  10.1186/s13041-021-00766-x
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06900, KAKENHI-PROJECT-19K06899
[Journal Article] Urinary <scp>FABP1</scp> is a biomarker for impaired proximal tubular protein reabsorption and is synergistically enhanced by concurrent liver injury2021
- Author(s)
  Kawakami Ryo, Matsui Miki, Konno Ayumu, Kaneko Ryosuke, Shrestha Suman, Sunaga Hiroaki, Hanaoka Hirofumi, Goto Sawako, Hosojima Michihiro, Kabasawa Hideyuki, Obokata Masaru, Koitabashi Norimichi, Matsui Hiroki, Sasaki Tsutomu, Saito Akihiko, Yanagita Motoko, Hirai Hirokazu, Kurabayashi Masahiko, Iso Tatsuya
- Journal Title
  
  The Journal of Pathology
  
  Volume: 255 Issue: 4 Pages: 362-373
- DOI
  10.1002/path.5775
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K11788, KAKENHI-PROJECT-19K20107, KAKENHI-PUBLICLY-19H04895, KAKENHI-PROJECT-20H03697, KAKENHI-PROJECT-19K06899, KAKENHI-PROJECT-20K08878, KAKENHI-PROJECT-20H02932
[Journal Article] Therapeutic potential of d-cysteine against in vitro and in vivo models of spinocerebellar ataxia2021
- Author(s)
  Ohta Tomoko、Morikawa Yuri、Sato Masahiro、Konno Ayumu、Hirai Hirokazu、Kurauchi Yuki、Hisatsune Akinori、Katsuki Hiroshi、Seki Takahiro
- Journal Title
  
  Experimental Neurology
  
  Volume: 343 Pages: 113791-113791
- DOI
  10.1016/j.expneurol.2021.113791
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07123, KAKENHI-PROJECT-19K22813, KAKENHI-PROJECT-20H04126, KAKENHI-PROJECT-19K06899, KAKENHI-PROJECT-19K07101
[Journal Article] Efficient whole brain transduction by systemic infusion of minimally purified AAV-PHP.eB2020
- Author(s)
  Konno Ayumu、Hirai Hirokazu
- Journal Title
  
  Journal of Neuroscience Methods
  
  Volume: 346 Pages: 108914-108914
- DOI
  10.1016/j.jneumeth.2020.108914
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02521, KAKENHI-PROJECT-19K06899
[Journal Article] Distinct temporal integration of noradrenaline signaling by astrocytic second messengers during vigilance2020
- Author(s)
  Oe Yuki、Wang Xiaowen、Patriarchi Tommaso、Konno Ayumu、Ozawa Katsuya、Yahagi Kazuko、Hirai Hirokazu、Tian Lin、McHugh Thomas J.、Hirase Hajime
- Journal Title
  
  Nature Communications
  
  Volume: 11 Issue: 1 Pages: 471-471
- DOI
  10.1038/s41467-020-14378-x
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06899, KAKENHI-PUBLICLY-18H05150, KAKENHI-PUBLICLY-19H05233, KAKENHI-PROJECT-16H01888, KAKENHI-PROJECT-18H02521
[Journal Article] Glucocorticoids negatively regulates chaperone mediated autophagy and microautophagy2020
- Author(s)
  Sato Masahiro、Ueda Erika、Konno Ayumu、Hirai Hirokazu、Kurauchi Yuki、Hisatsune Akinori、Katsuki Hiroshi、Seki Takahiro
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 528 Issue: 1 Pages: 199-205
- DOI
  10.1016/j.bbrc.2020.04.132
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07101, KAKENHI-PROJECT-19K07123, KAKENHI-PROJECT-19K22813, KAKENHI-PROJECT-20H04126, KAKENHI-PROJECT-19K06899
[Journal Article] Global Knockdown of Retinoid-related Orphan Receptor α in Mature Purkinje Cells Reveals Aberrant Cerebellar Phenotypes of Spinocerebellar Ataxia2020
- Author(s)
  Yasui Hiroyuki、Matsuzaki Yasunori、Konno Ayumu、Hirai Hirokazu
- Journal Title
  
  Neuroscience
  
  Volume: - Pages: 328-336
- DOI
  10.1016/j.neuroscience.2020.04.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02521, KAKENHI-PROJECT-19K06899
[Journal Article] Ataxic phenotype and neurodegeneration are triggered by the impairment of chaperone‐mediated autophagy in cerebellar neurons2020
- Author(s)
  Sato Masahiro、Ohta Tomoko、Morikawa Yuri、Konno Ayumu、Hirai Hirokazu、Kurauchi Yuki、Hisatsune Akinori、Katsuki Hiroshi、Seki Takahiro
- Journal Title
  
  Neuropathology and Applied Neurobiology
  
  Volume: 47 Issue: 2 Pages: 198-209
- DOI
  10.1111/nan.12649
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07101, KAKENHI-PROJECT-19K07123, KAKENHI-PROJECT-19K22813, KAKENHI-PROJECT-18H02521, KAKENHI-PROJECT-20H04126, KAKENHI-PROJECT-19K06899
[Journal Article] Deletion of Class II ADP-Ribosylation Factors in Mice Causes Tremor by the Nav1.6 Loss in Cerebellar Purkinje Cell Axon Initial Segments.2019
- Author(s)
  Hosoi N, Shibasaki K, Hosono M, Konno A, Shinoda Y, Kiyonari H, Inoue K, Muramatsu SI, Ishizaki Y, Hirai H, Furuichi T, Sadakata T
- Journal Title
  
  J Neurosci
  
  Volume: 39(32) Issue: 32 Pages: 6339-6353
- DOI
  10.1523/jneurosci.2002-18.2019
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K07103, KAKENHI-PROJECT-19K06899, KAKENHI-PROJECT-19K06900, KAKENHI-PROJECT-18K19418, KAKENHI-PLANNED-15H05934, KAKENHI-PROJECT-18H02522, KAKENHI-PROJECT-18H03124, KAKENHI-PROJECT-17H03563
[Journal Article] Rapamycin activates mammalian microautophagy2019
- Author(s)
  Sato Masahiro、Seki Takahiro、Konno Ayumu、Hirai Hirokazu、Kurauchi Yuki、Hisatsune Akinori、Katsuki Hiroshi
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: 140 Issue: 2 Pages: 201-204
- DOI
  10.1016/j.jphs.2019.05.007
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K06899, KAKENHI-PROJECT-19K07101, KAKENHI-PROJECT-19K07123, KAKENHI-PROJECT-16H04673, KAKENHI-PROJECT-17J08433
[Journal Article] Advanced CUBIC tissue clearing for whole-organ cell profiling2019
- Author(s)
  Matsumoto Katsuhiko、Mitani Tomoki T.、Horiguchi Shuhei A.、Kaneshiro Junichi、Murakami Tatsuya C.、Mano Tomoyuki、Fujishima Hiroshi、Konno Ayumu、Watanabe Tomonobu M.、Hirai Hirokazu、Ueda Hiroki R.
- Journal Title
  
  Nature Protocols
  
  Volume: 14 Issue: 12 Pages: 3506-3537
- DOI
  10.1038/s41596-019-0240-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K06899, KAKENHI-PLANNED-18H05409, KAKENHI-PROJECT-18H02521, KAKENHI-PROJECT-19J13071
[Journal Article] Elavl3 is essential for the maintenance of Purkinje neuron axons2018
- Author(s)
  Ogawa Yuki、Kakumoto Kyoko、Yoshida Tetsu、Kuwako Ken-ichiro、Miyazaki Taisuke、Yamaguchi Junji、Konno Ayumu、Hata Junichi、Uchiyama Yasuo、Hirai Hirokazu、Watanabe Masahiko、Darnell Robert B.、Okano Hideyuki、Okano Hirotaka James
- Journal Title
  
  Sci Rep.
  
  Volume: 8 Issue: 1 Pages: 2722-2722
- DOI
  10.1038/s41598-018-21130-5
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08485, KAKENHI-PROJECT-17K09766, KAKENHI-PROJECT-16J11920, KAKENHI-PROJECT-15K06807, KAKENHI-PROJECT-16K14581, KAKENHI-PROJECT-16K15477, KAKENHI-PROJECT-15K18330
[Journal Article] Intravenous administration of the adeno-associated virus-PHP.B capsid fails to upregulate transduction efficiency in the marmoset brain2018
- Author(s)
  Matsuzaki Yasunori、Konno Ayumu、Mochizuki Ryuta、Shinohara Yoichiro、Nitta Keisuke、Okada Yukihiro、Hirai Hirokazu
- Journal Title
  
  Neuroscience Letters
  
  Volume: 665 Pages: 182-188
- DOI
  10.1016/j.neulet.2017.11.049
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K14929, KAKENHI-PROJECT-15H04254, KAKENHI-PROJECT-16K15477, KAKENHI-PROJECT-15K18330
[Journal Article] Regulatory connection between the expression level of classical protein kinase C and pruning of climbing fibers from cerebellar Purkinje cells2017
- Author(s)
  Takahashi Nobutaka、Shuvaev Anton N.、Konno Ayumu、Matsuzaki Yasunori、Watanave Masashi、Hirai Hirokazu
- Journal Title
  
  Journal of Neurochemistry
  
  Volume: 143 Issue: 6 Pages: 660-670
- DOI
  10.1111/jnc.14239
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K14929, KAKENHI-PROJECT-15H04254, KAKENHI-PROJECT-16K15477, KAKENHI-PROJECT-15K18330
[Journal Article] Viral Vector-Based Evaluation of Regulatory Regions in the Neuron-Specific Enolase (NSE) Promoter in Mouse Cerebellum In Vivo2017
- Author(s)
  Shinohara Yoichiro、Ohtani Toshinori、Konno Ayumu、Hirai Hirokazu
- Journal Title
  
  The Cerebellum
  
  Volume: 16 Issue: 5-6 Pages: 913-922
- DOI
  10.1007/s12311-017-0866-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K15477, KAKENHI-PROJECT-15K18330
[Journal Article] Minimal Purkinje Cell-Specific PCP2/L7 Promoter Virally Available for Rodents and Non-human Primates2017
- Author(s)
  Nitta Keisuke、Matsuzaki Yasunori、Konno Ayumu、Hirai Hirokazu
- Journal Title
  
  Molecular Therapy - Methods & Clinical Development
  
  Volume: 6 Pages: 159-170
- DOI
  10.1016/j.omtm.2017.07.006
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K14929, KAKENHI-PROJECT-15H04254, KAKENHI-PROJECT-16K15477, KAKENHI-PROJECT-15K18330
[Journal Article] CD38 positively regulates postnatal development of astrocytes cell-autonomously and oligodendrocytes non-cell-autonomously.2017
- Author(s)
  Hattori T, Kaji M, Ishii H, Jureepon R, Takarada-Iemata M, Ta HM, Le TM, Konno A, Hirai H, Shiraishi Y, Ozaki N, Yamamoto Y, Okamoto H, Yokoyama S, Higashida H, Kitao Y, Hori O.
- Journal Title
  
  Glia
  
  Volume: 印刷中 Issue: 6 Pages: 974-989
- DOI
  10.1002/glia.23139
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01374, KAKENHI-PROJECT-26430069, KAKENHI-PROJECT-15K18374, KAKENHI-PROJECT-15K06753, KAKENHI-PROJECT-15H04254
[Journal Article] Red fluorescent protein-based cAMP indicator applicable to optogenetics and in vivo imaging2017
- Author(s)
  Harada Kazuki、Ito Motoki、Wang Xiaowen、Tanaka Mika、Wongso Devina、Konno Ayumu、Hirai Hirokazu、Hirase Hajime、Tsuboi Takashi、Kitaguchi Tetsuya
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Issue: 1 Pages: 7351-7351
- DOI
  10.1038/s41598-017-07820-6
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K01922, KAKENHI-PROJECT-15H04254, KAKENHI-PROJECT-16J06838, KAKENHI-PROJECT-26460289, KAKENHI-PROJECT-16K15477, KAKENHI-PROJECT-15K18330
[Journal Article] FMRP Expression Levels in Mouse CNS Neurons Determine Behavioral Phenotype.2016
- Author(s)
  Arsenault J, Gholizadeh S, Niibori Y, Pacey LK, Halder SK, Koxhioni E, Konno A, Hirai H, Hampson DR
- Journal Title
  
  Human Gene Therapy
  
  Volume: 27 Issue: 12 Pages: 982-996
- DOI
  10.1089/hum.2016.090
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18330, KAKENHI-PROJECT-15H04254
[Journal Article] Calcium imaging reveals glial involvement in transcranial direct current stimulation-induced plasticity in mouse brain2016
- Author(s)
  H Monai, M Ohkura, M Tanaka, Y Oe, A Konno, H Hirai, K Mikoshiba, S Itohara, J Nakai, Y Iwai & H Hirase
- Journal Title
  
  Nature communications
  
  Volume: 7 Issue: 1 Pages: 11100-11100
- DOI
  10.1038/ncomms11100
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K14326, KAKENHI-PROJECT-15K18330, KAKENHI-PUBLICLY-15H01275, KAKENHI-PUBLICLY-26115504, KAKENHI-PUBLICLY-26117520, KAKENHI-PROJECT-15H05723, KAKENHI-PROJECT-26640002, KAKENHI-PROJECT-26282217, KAKENHI-PROJECT-25221002
[Journal Article] Fusion of Human Fetal Mesenchymal Stem Cells with “Degenerating” Cerebellar Neurons in Spinocerebellar Ataxia Type 1 Model Mice.2016
- Author(s)
  Huda F, Fan Y, Suzuki M, Konno A, Matsuzaki Y, Takahashi N, Chan JK, Hirai H
- Journal Title
  
  PLoS ONE
  
  Volume: 11 Issue: 11 Pages: e0164202-e0164202
- DOI
  10.1371/journal.pone.0164202
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18330
[Journal Article] Plasticity of the developmentally arrested staggerer cerebellum in response to exogenous RORα.2016
- Author(s)
  Iizuka A, Matsuzaki Y, Konno A, Hirai H.
- Journal Title
  
  Brain Structure and Function
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H04254
[Journal Article] Viral Vector-Based Dissection of Marmoset GFAP Promoter in Mouse and Marmoset Brains.2016
- Author(s)
  Shinohara Y, Konno A, Takahashi N, Matsuzaki Y, Kishi S, Hirai H
- Journal Title
  
  PLoS ONE
  
  Volume: 11 Issue: 8 Pages: e0162023-e0162023
- DOI
  10.1371/journal.pone.0162023
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K18330
[Journal Article] Transduction Profile of the Marmoset Central Nervous System Using Adeno-Associated Virus Serotype 9 Vectors2016
- Author(s)
  Matsuzaki Y, Konno A, Mukai R, Honda F, Hirato M, Yoshimoto Y, Hirai H.
- Journal Title
  
  Molecular Neurobiology
  
  Volume: in press Issue: 3 Pages: 1-16
- DOI
  10.1007/s12035-016-9777-6
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18330, KAKENHI-PROJECT-26462199
[Journal Article] Inflammation-induced reversible switch of the neuron-specific enolase promoter from Purkinje neurons to Bergmann glia.2016
- Author(s)
  Sawada Y, Konno A, Nagaoka J, Hirai H
- Journal Title
  
  Scientific Reports
  
  Volume: 6 Issue: 1 Pages: 27758-27758
- DOI
  10.1038/srep27758
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K18330
[Journal Article] Fluorescent-based evaluation of chaperone-mediated autophagy and microautophagy activities in cultured cells.2016
- Author(s)
  Sato M, Seki T, Konno A, Hirai H, Kurauchi Y, Hisatsune A, Katsuki H.
- Journal Title
  
  Genes to Cells
  
  Volume: 21 Issue: 8 Pages: 861-873
- DOI
  10.1111/gtc.12390
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16H04673, KAKENHI-PROJECT-15K18865, KAKENHI-PROJECT-16K08276, KAKENHI-PROJECT-16K15204, KAKENHI-PROJECT-15K18330
[Journal Article] Plasticity of the developmentally arrested staggerer cerebellum in response to exogenous RORα.2015
- Author(s)
  Iizuka A, Matsuzaki Y, Konno A, Hirai H.
- Journal Title
  
  Brain Structure and Function
  
  Volume: in press Issue: 6 Pages: 1-11
- DOI
  10.1007/s00429-015-1077-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K18330
[Journal Article] Mutant ataxin-3 with an abnormally expanded polyglutamine chain disrupts dendritic development and metabotropic glutamate receptor signaling in mouse cerebellar purkinje cells2014
- Author(s)
  Konno A, Shuvaev AN, Miyake N, Miyake K, Iizuka A, Matsuura S, Huda F, Nakamura K, Yanagi S, Shimada T, Hirai H.
- Journal Title
  
  Cerebellum
  
  Volume: 13 Issue: 1 Pages: 29-41
- DOI
  10.1007/s12311-013-0516-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591554, KAKENHI-PUBLICLY-24111545, KAKENHI-PROJECT-24590407, KAKENHI-PROJECT-24591529, KAKENHI-PROJECT-24700394, KAKENHI-PROJECT-24800008, KAKENHI-PROJECT-25640040
[Journal Article] One-year follow-up of gene expression by integrase-defective lentiviral vectors and their therapeutic potential in spinocerebellar ataxia model mice.2014
- Author(s)
  Saida H, Matsuzaki Y, Takayama K, Iizuka A, Konno A, Yanagi S, and Hirai H.
- Journal Title
  
  Gene Therapy
  
  Volume: 21 Issue: 9 Pages: 820-827
- DOI
  10.1038/gt.2014.60
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24700394, KAKENHI-PUBLICLY-26111724, KAKENHI-PROJECT-26293072
[Journal Article] Distinct transduction profiles in the CNS via 3 injection routes of AAV9 and the application to generation of a neurodegenerative mouse model.2014
- Author(s)
  Huda F, Konno A, Matsuzaki Y, Goenawan H, Miyake K, Shimada T, Hirai H
- Journal Title
  
  Molecular Therapy - Methods and Clinical Development
  
  Volume: 1 Pages: 14032-14032
- DOI
  10.1038/mtm.2014.32
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24700394
[Patent] 改良型ミクログリア標的ＡＡＶベクター2024
- Inventor(s)
  平井宏和、今野歩、青木遼
- Industrial Property Rights Holder
  平井宏和、今野歩、青木遼
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2024-013394
- Filing Date
  2024
- Data Source
  KAKENHI-PROJECT-22K06454
[Patent] 改良型ミクログリア標的ＡＡＶベクター2024
- Inventor(s)
  平井宏和, 今野　歩, 青木　遼
- Industrial Property Rights Holder
  平井宏和, 今野　歩, 青木　遼
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2024-013394
- Filing Date
  2024
- Data Source
  KAKENHI-PROJECT-23K27482
[Patent] 血管平滑筋指向性アデノ随伴ウイルスベクター2023
- Inventor(s)
  瀬原吉英、今野歩
- Industrial Property Rights Holder
  瀬原吉英、今野歩
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2023-117434
- Filing Date
  2023
- Data Source
  KAKENHI-PROJECT-22K06454
[Patent] 抑制性ニューロン特異的プロモーター2022
- Inventor(s)
  平井宏和、今野歩、松﨑泰教、深井悠貴
- Industrial Property Rights Holder
  平井宏和、今野歩、松﨑泰教、深井悠貴
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2022-079298
- Filing Date
  2022
- Data Source
  KAKENHI-PROJECT-22K06454
[Patent] 抑制性ニューロン特異的プロモーター2022
- Inventor(s)
  平井宏和、今野歩、松﨑泰教、深井悠貴
- Industrial Property Rights Holder
  平井宏和、今野歩、松﨑泰教、深井悠貴
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2022-079298
- Filing Date
  2022
- Data Source
  KAKENHI-PROJECT-19K06899
[Presentation] AAVベクターの静脈投与のみでコンディショナルノックアウトを行う手法2024
- Author(s)
  今野歩、川畑勇人、平井宏和
- Organizer
  NEURO2024
- Data Source
  KAKENHI-PROJECT-22K06454
[Presentation] マウス及びマーモセットの脳内のさまざまな細胞種特異的AAVベクターの開発2024
- Author(s)
  平井宏和、深井悠貴、川畑勇人、青木遼、松崎泰教、今野歩
- Organizer
  第 101 回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-23K27482
[Presentation] 脳内のさまざまな細胞種標的AAVベクターの開発2024
- Author(s)
  平井宏和、今野歩、松崎泰教、堤咲樹、深井悠貴、青木遼
- Organizer
  第６回 JMU-CGTRシンポジウム 2024
- Invited
- Data Source
  KAKENHI-PROJECT-23K27482
[Presentation] アデノ随伴ウイルスベクターの静脈内投与による脳内細胞種特異的な遺伝子発現法の開発2023
- Author(s)
  平井宏和、川畑勇人、深井悠貴、松崎泰教、今野歩
- Organizer
  第29回日本遺伝子細胞治療学会学術集会
- Data Source
  KAKENHI-PROJECT-23K27482
[Presentation] Development of a method for the gene expression preferentially in microglia using an adeno-associated virus vector2023
- Author(s)
  今野歩、岡田如弘、松崎泰教、平井宏和
- Organizer
  日本生理学会第100回記念大会
- Data Source
  KAKENHI-PROJECT-19K06899
[Presentation] Development of a method for the gene expression preferentially in microglia using an adeno-associated virus vector2023
- Author(s)
  今野歩、岡田如弘、松崎泰教、平井宏和
- Organizer
  日本生理学会第100回記念大会
- Data Source
  KAKENHI-PROJECT-22K06454
[Presentation] アデノ随伴ウイルスベクターの静脈投与を介したマウス脳への細胞種特異的遺伝子導入2022
- Author(s)
  今野歩
- Organizer
  日本薬物動態学会第37回年会
- Invited
- Data Source
  KAKENHI-PROJECT-22K06454
[Presentation] 血液脳関門透過型AAVベクターによる細胞種特異的遺伝子発現2022
- Author(s)
  今野歩
- Organizer
  第96 回日本薬理学会年会/ 第43 回日本臨床薬理学会学術総会
- Data Source
  KAKENHI-PROJECT-19K06899
[Presentation] 血液脳関門透過型AAVベクターによる細胞種特異的遺伝子発現2022
- Author(s)
  今野歩
- Organizer
  第96 回日本薬理学会年会/ 第43 回日本臨床薬理学会学術総会
- Data Source
  KAKENHI-PROJECT-22K06454
[Presentation] アデノ随伴ウイルスベクターの静脈投与を介したマウス脳への細胞種特異的遺伝子導入2022
- Author(s)
  今野歩
- Organizer
  日本薬物動態学会第37回年会
- Invited
- Data Source
  KAKENHI-PROJECT-19K06899
[Presentation] アデノ随伴ウイルスベクターの超簡易精製法2019
- Author(s)
  今野歩、平井宏和
- Organizer
  第42回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-19K06899
[Presentation] In vivo evaluation of efficacy of the shortened WPRE sequence in cerebellum2017
- Author(s)
  Ayumu Konno, Kazuma Hachisu, Rika terashima, Hirokazu Hirai
- Organizer
  第40回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-15H04254
[Presentation] AAV9 vector-mediated production of mouse model of spinocerebellar ataxia type 3 and electrophysiological analysis of the mouse2017
- Author(s)
  Chiaki Hoshino, Masashi Watanabe, Ayumu Konno, Hirokazu Hirai
- Organizer
  第40回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-15H04254
[Presentation] アデノ随伴ウイルスによる遺伝子導入を介したリピート病モデル動物の作出と治療法の開発2017
- Author(s)
  今野歩, 渡邊将, 星野千秋, 篠原洋一郎, 松﨑泰教, 平井宏和
- Organizer
  2017年度生命科学系学会合同年次大会（ConBio2017）
- Data Source
  KAKENHI-PROJECT-15K18330
[Presentation] AAV9 vector-mediated production of mouse model of spinocerebellar ataxia type 3 and electrophysiological analysis of that mouse2017
- Author(s)
  Chiaki Hoshino, Masashi Watanabe, Ayumu Konno, Hirokazu Hirai
- Organizer
  第40回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-16K15477
[Presentation] Pros and cons of an AAV double infection method combined with the Tet system :An experimental study2017
- Author(s)
  Nobutake Hosoi, Masayuki Shichida, Ayumu Konno, Hirokazu Hirai
- Organizer
  Neuroscience 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15477
[Presentation] In vivo evaluation of the shortened-WPRE in the cerebellum2017
- Author(s)
  Ayumu Konno, Kazuma Hachisu, Hirokazu Hirai
- Organizer
  第40回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-16K15477
[Presentation] Regulation of the firing property in mature Purkinje cells by PKC γ contributes to the motor coordination2017
- Author(s)
  Masashi Watanabe, Nobutaka Takahashi, Ayumu Konno, Hirokazu Hirai
- Organizer
  第40回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-15H04254
[Presentation] アデノ随伴ウイルスによる遺伝子導入を介したリピート病モデル動物の作出と治療法の開発2017
- Author(s)
  今野歩, 渡邊将, 星野千秋, 篠原洋一郎, 松﨑泰教, 平井宏和
- Organizer
  2017年度生命科学系学会合同年次大会（ConBio2017）
- Data Source
  KAKENHI-PROJECT-16K15477
[Presentation] In vivo evaluation of the shortened-WPRE in the cerebellum2017
- Author(s)
  Ayumu Konno, Kazuma Hachisu, Hirokazu Hirai
- Organizer
  第40回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-15K18330
[Presentation] Pros and cons of an AAV double infection method combined with the Tet system: An experimental study2017
- Author(s)
  Ayumu Konno, Hirokazu Hirai
- Organizer
  Neuroscience 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04254
[Presentation] Impaired synaptic plasticity at cerebellar parallel fiber-Purkinje cell synapses in AAV vector-based mouse model of spinocerebellar ataxia type 32016
- Author(s)
  Masashi Watanabe, Ayumu Konno, Hirokazu Hirai
- Organizer
  第３９回日本神経科学大会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-07-20
- Data Source
  KAKENHI-PROJECT-16K15477
[Presentation] AAV9 vector-mediated production of animal models of spinocerebellar ataxia2016
- Author(s)
  Ayumu Konno, Yasunori Matsuzaki & Hirokazu Hirai
- Organizer
  International Society of Radiation Neurobiology 6th Conference
- Place of Presentation
  良順会館（長崎大学医学部坂本キャンパス内）/長崎県長崎市
- Year and Date
  2016-02-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18330
[Presentation] Probing expression pattern of a novel AAV double infection method combined with the Tet system and the glia specific GFAP promoter2016
- Author(s)
  Nobutake Hosoi, Masayuki Shichida, Ayumu Konno and Hirokazu Hirai
- Organizer
  10th FENS Forum of Neuroscience
- Place of Presentation
  コペンハーゲン　（デンマーク）
- Year and Date
  2016-07-02
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25430003
[Presentation] Generation of animal models of spinocerebellar ataxia by AAV9-mediated gene delivery2016
- Author(s)
  Ayumu Konno, Yasunori Matsuzaki & Hirokazu Hirai
- Organizer
  第93回日本生理学会大会
- Place of Presentation
  札幌コンベンションセンター/北海道札幌市
- Year and Date
  2016-03-22
- Data Source
  KAKENHI-PROJECT-15K18330
[Presentation] Generation of a marmoset model of spinocerebellar ataxia type 3 via AAV9 vector-mediated gene transfer2016
- Author(s)
  Ayumu Konno, Yasunori Matsuzaki, Hirokazu Hirai
- Organizer
  Neuroscience 2016
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04254
[Presentation] 短縮型マウスGFAPプロモーターとTet systemを組み合わせた新規AAV二重感染法による遺伝子発現のグリア特異性の検討2015
- Author(s)
  七田真之、細井延武、今野歩、平井宏和
- Organizer
  第38回日本神経科学大会
- Place of Presentation
  神戸国際会議場、神戸国際展示場（兵庫県神戸市）
- Year and Date
  2015-07-28
- Data Source
  KAKENHI-PROJECT-25430003
[Presentation] 短縮型マウスGFAPプロモーターとTet systemを組み合わせたAAV二重感染法による遺伝子発現のグリア特異性の検討2015
- Author(s)
  七田　真之、細井　延武、　今野　歩、　平井　宏和
- Organizer
  第5回国際放射線神経生物学会大会
- Place of Presentation
  高崎シティギャラリー　（群馬県高崎市）
- Year and Date
  2015-02-21
- Data Source
  KAKENHI-PROJECT-25430003
[Presentation] Producing animal models of spinocerebellar ataxia type 3 via a viral vector-mediated gene delivery2015
- Author(s)
  Ayumu Konno, Yasunori Matsuzaki & Hirokazu Hirai
- Organizer
  International Society of Radiation Neurobiology 5th Conference
- Place of Presentation
  Takasaki City Gallery
- Year and Date
  2015-02-21
- Data Source
  KAKENHI-PROJECT-24700394
[Presentation] A marmoset model of spinocerebellar ataxia type 3 generated using AAV vectors2015
- Author(s)
  Ayumu Konno, Yasunori Matsuzaki, Yoichiro Shinohara, and Hirokazu Hirai
- Organizer
  第38回日本神経科学大会
- Place of Presentation
  神戸国際会議場/展示場・兵庫県神戸市
- Year and Date
  2015-07-28
- Data Source
  KAKENHI-PROJECT-15K18330
[Presentation] Production of animal models of spinocerebellar ataxia type 3 by a viral vector-mediated gene delivery2014
- Author(s)
  Ayumu Konno, Yasunori Matsuzaki, Naoya Ohta, Hirokazu Hirai
- Organizer
  1st International Symposium of Gunma University Medical Innovation and 6th International Conference on Advanced Micro-Device Engineering
- Place of Presentation
  Kiryu City Performing Arts Center
- Year and Date
  2014-12-05
- Data Source
  KAKENHI-PROJECT-24700394
[Presentation] アデノ随伴ウイルスによる小脳全域への遺伝子導入を介した脊髄小脳変性症3型モデル動物の作出2014
- Author(s)
  今野歩、松﨑泰教、平井宏和
- Organizer
  2014年度包括型脳科学研究推進支援ネットワーク冬のワークショップ
- Place of Presentation
  東京ガーデンパレス・東京都
- Year and Date
  2014-12-12
- Data Source
  KAKENHI-PROJECT-24700394
[Presentation] AAV9 vector-mediated production of animal models of spinocerebellar ataxia type 32014
- Author(s)
  Ayumu Konno, Hirokazu Hirai
- Organizer
  第37回日本神経科学大会
- Place of Presentation
  パシフィコ横浜・横浜市
- Year and Date
  2014-09-13
- Data Source
  KAKENHI-PROJECT-24700394
[Presentation] Disruption of mGluR signaling in SCA3 model mice expressing mutant ataxin-3 and the partial restoration via intravenous administration of AAV92013
- Author(s)
  A. KONNO, A. N. SHUVAEV, S. YANAGI, H. HIRAI
- Organizer
  23rd Neuropharmacology Conference
- Place of Presentation
  Sheraton San Diego Hotel and Marina, San Diego, California, USA
- Data Source
  KAKENHI-PROJECT-24700394
[Presentation] Deficient metabotropic glutamate receptor signaling and rescue through intravascular administration of AAV9 in a mouse model of spinocerebellar ataxia type 32013
- Author(s)
  今野歩，Anton N Shuvaev，三宅紀子，三宅弘一，柳茂，島田隆，平井宏和
- Organizer
  Neuro2013（第36回日本神経科学大会）
- Place of Presentation
  国立京都国際会館・京都府京都市
- Data Source
  KAKENHI-PROJECT-24700394
[Presentation] Perturbation of mGluR signaling in SCA3 model mice expressing mutant ataxin-3 and the rescue by intravascular administration of AAV92013
- Author(s)
  A. KONNO, A. N. SHUVAEV, S. YANAGI, H. HIRAI
- Organizer
  Neuroscience2013
- Place of Presentation
  San Diego Convention Center, San Diego, California, USA
- Data Source
  KAKENHI-PROJECT-24700394
[Presentation] DISRUPTION OF METABOTROPIC GLUTAMATE RECEPTOR SIGNALING AND RESCUE THROUGH INTRAVASCULAR ADMINISTRATION OF AAV9 IN A MOUSE MODEL OF SPINOCEREBELLAR ATAXIA TYPE 32013
- Author(s)
  Ayumu Konno, Anton N. Shuvaev, Noriko Miyake, Koichi Miyake, Shigeru Yanagi, Takashi Shimada, Hirokazu Hirai
- Organizer
  第19回日本遺伝子治療学会学術集会
- Place of Presentation
  岡山コンベンションセンター・岡山県岡山市
- Data Source
  KAKENHI-PROJECT-24700394
[Presentation] DISRUPTION OF METABOTROPIC GLUTAMATE RECEPTOR SIGNALING AND RESCUE THROUGH INTRAVASCULAR ADMINISTRATION OF AAV9 IN A MOUSE MODEL OF SPINOCEREBELLAR ATAXIA TYPE 32013
- Author(s)
  今野歩，Anton N Shuvaev，三宅紀子，三宅弘一，柳茂，島田隆，平井宏和
- Organizer
  第19回遺伝子治療学会
- Place of Presentation
  岡山コンベンションセンター
- Data Source
  KAKENHI-PROJECT-24700394
[Presentation] Deficient metabotropic glutamate receptor signaling and rescue through intravascular administration of AAV9 in a mouse model of spinocerebellar ataxia type 3
- Author(s)
  今野歩，Anton N Shuvaev，三宅紀子，三宅弘一，柳茂，島田隆，平井宏和
- Organizer
  Neuro2013(第36回日本神経科学大会、第56回日本神経化学会大会、第23回日本神経回路学会大会)
- Place of Presentation
  国立京都国際会館
- Data Source
  KAKENHI-PROJECT-24700394
[Presentation] Gene therapy for spinocerebellar ataxia type-3 using trans-blood-brain barrier gene delivery by AAV9
- Author(s)
  今野歩，Anton N Shuvaev，三宅紀子，三宅弘一，柳茂，島田隆，平井宏和
- Organizer
  第35回日本神経科学大会
- Place of Presentation
  名古屋国際会議場・愛知県名古屋市
- Data Source
  KAKENHI-PROJECT-24700394

1. HIRAI Hirokazu (70291086)

# of Collaborated Projects: 5 results

# of Collaborated Products: 20 results
2. HOSOI Nobutake (90543570)

# of Collaborated Projects: 4 results

# of Collaborated Products: 9 results
3. 太田宏之 (20535190)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. MATSUZAKI Yasunori (50738200)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
5. 渡邉康春 (80646307)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
6. 中野高志 (70579953)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. IIZUKA Akira (10466683)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. NAKAMURA Kazuhiro (10327835)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. Hirase Hajime (90392084)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 守本祐司 (10449069)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 古賀農人 (70744936)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 山崎雄 (70866243)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 島孟留 (60846377)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 六本木麗子 (80719857)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. AMO Taku

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. MIYAZAKI Taisuke

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. MATSUI Hiroki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. TAKARADA Mika

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. KURAUCHI Yuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
20. SAITO Taku

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. TSUBOI Takashi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. KITAGUCHI Tetsuya

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 金明月

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. 三宅弘一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. 稲田健吾

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
26. 岩井陽一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
27. 定方哲史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
28. 須永浩章

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
29. 香月博志

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
30. 井ノ口馨

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
31. 関貴弘

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Konno Ayumu 今野 歩

KONNO Ayumu 今野 歩

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Development of highly efficient trans-synaptic AAV vector mutantsPrincipal Investigator

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AAVベクターの静脈投与のみでコンディショナルノックアウトを行う手法の開発Principal Investigator

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Development of a technique that allows repeatable gene transfer into the brain using AAV vectorsPrincipal Investigator

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Development of a novel gene therapy method via CRISPR/Cas9 mediated in vivo genome editingPrincipal Investigator

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Konno Ayumu 今野歩

KONNO Ayumu 今野歩

[Book] ２章ウイルスベクターを用いた遺伝子導入プロトコール：６－静脈投与によるマウス脳全域への遺伝子導入 in 「決定版　ウイルスベクターによる遺伝子導入実験ガイド」2020

[Book] １章各ウイルスベクターの特徴と作製の基本：２－AAVベクター in 「決定版　ウイルスベクターによる遺伝子導入実験ガイド」2020