OOGAI Yuichi 大貝悠一

… Alternative Names

Oogai Yuichi 大貝悠一

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Researcher Number	40511259
Other IDs
External Links
Affiliation (Current)	2025: 鹿児島大学, 医歯学域歯学系, 講師
Affiliation (based on the past Project Information) *help	2022 – 2024: 鹿児島大学, 医歯学域歯学系, 講師 2015 – 2021: 鹿児島大学, 医歯学域歯学系, 助教 2013 – 2014: 鹿児島大学, 医歯(薬)学総合研究科, 助教 2011: 鹿児島大学, 医歯学総合研究科口腔微生物学分野 2011: 鹿児島大学, 大学院・医歯学総合研究科, 助教 2010 – 2011: 鹿児島大学, 医歯学総合研究科, 助教 2008: 鹿児島大学, 大学院・医歯学総合研究科, 助教
Review Section/Research Field	Principal Investigator Morphological basic dentistry / Basic Section 57020:Oral pathobiological science-related Except Principal Investigator Morphological basic dentistry / Basic Section 57020:Oral pathobiological science-related / Medium-sized Section 57:Oral science and related fields / Pathobiological dentistry/Dental radiology / Biological Sciences
Keywords	Principal Investigator 歯周病原因菌 / sRNA / small RNA / 外膜タンパク / 生体内定着 / TCS / 挿入配列 / Hfq / A. actinomycetemcomitans / small ORF … More / ペプチド / 生理活性ペプチド / 表層タンパク / 細菌学 / 補体抵抗性 … More Except Principal Investigator 黄色ブドウ球菌 / バクテリオシン / 口腔内細菌 / 抗菌性ペプチド / レンサ球菌 / 二成分制御系 / 薬剤耐性 / 口腔定着阻害 / ミュータンス菌 / 常在細菌叢 / 口腔細菌 / 細菌感染 / 上皮細胞 / 歯周病原因菌 / 抗菌ペプチド / 先天性免疫 / サーモセンサー / 線毛 / 一本鎖可変断片 / 天然由来成分 / ゲノムシーケンス / 口腔 / 多剤耐性菌 / 唾液 / ミュータンスレンサ球菌 / エコシステム / 感染免疫 / 抗菌性因子 / ブドウ球菌 / 口腔細菌叢 / マイクロバイオーム / 口腔定着 / ナイシン / 抗菌物質 / MRSA / 細菌叢 / 糖代謝 / small RNA / う蝕原因菌 / 常在細菌 / 抗菌力 / サイトイン / 炎症 / 免疫抑制 / 歯肉上皮細胞 / 口腔レンサ球菌 / ケモカイン / サイトカイン / 歯学 / 細菌 / 感染症 / 化学療法剤 / 発現調節機序 / 発現調節性因子 / 病原性因子 / 血清 Less

歯周病原因細菌の口腔から全身への定着に関与する因子の研究Principal Investigator
- Principal Investigator
  
  大貝悠一
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57020:Oral pathobiological science-related
- Research Institution
  Kagoshima University
口腔内の病原性共生細菌に対する一本鎖可変断片の創生と応用
- Principal Investigator
  
  中田匡宣
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 57:Oral science and related fields
- Research Institution
  Kagoshima University
RNAサーモセンサーとタンパク質重合体を介するレンサ球菌感染機構の探索
- Principal Investigator
  
  中田匡宣
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 57020:Oral pathobiological science-related
- Research Institution
  Kagoshima University
Analysis of small RNAs associated with the expression of virulence genes and insertional sequence in periodontal pathogenPrincipal Investigator
- Principal Investigator
  
  Oogai Yuichi
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57020:Oral pathobiological science-related
- Research Institution
  Kagoshima University
Search for naturally-deribved prebiotic factors that inhibit oral colonization of multidrug-resistant S. aureus
- Principal Investigator
  
  Kawada-Matsuo Miki
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57020:Oral pathobiological science-related
- Research Institution
  Hiroshima University
  Kagoshima University
Identification of bioactive peptides producing by A. actinomycetemcomitansPrincipal Investigator
- Principal Investigator
  
  Oogai Yuichi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Kagoshima University
Analysis of oral microbiome formation and effect on host immunity
- Principal Investigator
  
  Komatsuzawa Hitoshi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pathobiological dentistry/Dental radiology
- Research Institution
  Kagoshima University
Fundamental research toward development of infection prevention against oral cavity-derived multidrug resistant Staphylococcus aureus
- Principal Investigator
  
  KAWADA-MATSUO Miki
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Kagoshima University
Identification and virulence analysis of surface proteins in Aggregatibacter actinomycetemcomitansPrincipal Investigator
- Principal Investigator
  
  Oogai Yuichi
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Kagoshima University
Analysis for the existence of cariogenic and periodontal bacteria in oral cavity
- Principal Investigator
  
  KOMATSUZAWA Hitoshi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Kagoshima University
Does cytokine directly reacted with bacteria?
- Principal Investigator
  
  KOMATSUZAWA Hitoshi
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Kagoshima University
Identification and characterization of the surface proteins in periodontal pathogensPrincipal Investigator
- Principal Investigator
  
  OOGAI Yuichi
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Kagoshima University
黄色ブドウ球菌の病原性因子発現に影響を及ぼす外来性因子に関する研究
- Principal Investigator
  
  KOMATSUZAWA Hitoshi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kagoshima University
  Hiroshima University
Study on the interaction between periodontal bacteria and human antimicrobial peptides
- Principal Investigator
  
  KOMATSUZAWA Hitoshi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Kagoshima University
  Hiroshima University

All 2023 2021 2020 2019 2018 2017 2016 2015 2013 2010 2009 2008

All Journal Article Presentation

[Journal Article] Small regulatory RNAs of oral streptococci and periodontal bacteria2021
- Author(s)
  Yuichi Oogai and Masanobu Nakata
- Journal Title
  
  Jpn Dent Sci Rev .
  
  Volume: 57 Pages: 209-216
- DOI
  10.1016/j.jdsr.2021.09.004
- NAID
  210000172857
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09922, KAKENHI-PROJECT-19K22715
[Journal Article] Expression of virulence factors under different environmental conditions in Aggregatibacter actinomycetemcomitans2021
- Author(s)
  Fujita Ayumi、Oogai Yuichi、Kawada‐Matsuo Miki、Nakata Masanobu、Noguchi Kazuyuki、Komatsuzawa Hitoshi
- Journal Title
  
  Microbiology and Immunology
  
  Volume: 65 Issue: 3 Pages: 101-114
- DOI
  10.1111/1348-0421.12864
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09922, KAKENHI-PROJECT-18K09553
[Journal Article] Antibacterial activity of phellodendron bark against Streptococcus mutans.2020
- Author(s)
  Tsujii T, Kawada-Matsuo M, Migita H, Ohta K, Oogai Y, Yamasaki Y, Komatsuzawa H.
- Journal Title
  
  Microbiol Immunol.
  
  Volume: 64(6) Issue: 6 Pages: 424-434
- DOI
  10.1111/1348-0421.12787
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K09553
[Journal Article] Staphylococcus aureus Virulence Affected by an Alternative Nisin A Resistance Mechanism2020
- Author(s)
  Kawada-Matsuo M, Watanabe A, Arii K, Oogai Y, Noguchi K, Miyawaki S, Hayashi T, Komatsuzawa H
- Journal Title
  
  Appl Environ Microbiol.
  
  Volume: 86(8) Issue: 8
- DOI
  10.1128/aem.02923-19
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K09553
[Journal Article] Single mutations in BraRS confer high resistance against nisin A in Staphylococcus aureus.2019
- Author(s)
  Arii K, Kawada-Matsuo M, Oogai Y, Noguchi K, Komatsuzawa H.
- Journal Title
  
  Microbiologyopen
  
  Volume: Nov;8(11) Issue: 11
- DOI
  10.1002/mbo3.791
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K09553
[Journal Article] C55 bacteriocin produced by ETB-plasmid positive Staphylococcus aureus strains is a key factor for competition with S. aureus strains.2016
- Author(s)
  Kawada-Matsuo M, Shammi F, Oogai Y, Nakamura N, Sugai M, Komatsuzawa H
- Journal Title
  
  Microbiol Immunol.
  
  Volume: 60(3) Issue: 3 Pages: 139-147
- DOI
  10.1111/1348-0421.12360
- NAID
  40020779255
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K11017, KAKENHI-PROJECT-25460533, KAKENHI-PROJECT-15K20365
[Journal Article] Two-Component Systems Involved in Susceptibility to Nisin A in Streptococcus pyogenes.2016
- Author(s)
  Kawada-Matsuo M, Tatsuno I, Arii K, Zendo T, Oogai Y, Noguchi K, Hasegawa T, Sonomoto K, Komatsuzawa H.
- Journal Title
  
  Appl Environ Microbiol.
  
  Volume: 16；82（19） Issue: 19 Pages: 5930-5939
- DOI
  10.1128/aem.01897-16
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05036, KAKENHI-PROJECT-15K20365, KAKENHI-PROJECT-15K09575, KAKENHI-PROJECT-15K11017
[Journal Article] Staphylococcus aureus SrrAB Affects Susceptibility to Hydrogen Peroxide and Co-Existence with Streptococcus sanguinis.2016
- Author(s)
  Oogai Y, Kawada-Matsuo M, Komatsuzawa H.
- Journal Title
  
  PLoS One
  
  Volume: 11 Issue: 7 Pages: e0159768-e0159768
- DOI
  10.1371/journal.pone.0159768
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K20365, KAKENHI-PROJECT-15K11017
[Journal Article] Lysine and threonine biosynthesis from aspartate contributes to Staphylococcus aureus growth in calf serum.2016
- Author(s)
  Oogai, Y., Yamaguchi, M., Kawada-Matsuo, M., Sumitomo, T., Kawabata, S., Komatsuzawa, H.
- Journal Title
  
  Applied and Environmental Microbiology
  
  Volume: 82 Issue: 20 Pages: 6150-6157
- DOI
  10.1128/aem.01399-16
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05012, KAKENHI-PROJECT-16H05847, KAKENHI-PROJECT-26462779, KAKENHI-PROJECT-26462780, KAKENHI-PROJECT-15K20365, KAKENHI-PROJECT-16K15787
[Journal Article] Sugar Allocation to Metabolic Pathways is Tightly Regulated and Affects the Virulence of Streptococcus mutans.2016
- Author(s)
  Kawada-Matsuo M, Oogai Y, Komatsuzawa H.
- Journal Title
  
  Genes
  
  Volume: 8 Issue: 1 Pages: 11-11
- DOI
  10.3390/genes8010011
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K20365, KAKENHI-PROJECT-15K11017
[Journal Article] Antibacterial Effects of Glycyrrhetinic Acid and Its Derivatives on Staphylococcus aureus.2016
- Author(s)
  Oyama K, Kawada-Matsuo M, Oogai Y, Hayashi T, Nakamura N, Komatsuzawa H.
- Journal Title
  
  PLoS One
  
  Volume: 11 Issue: 11 Pages: e0165831-e0165831
- DOI
  10.1371/journal.pone.0165831
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K20365, KAKENHI-PROJECT-15K11017
[Journal Article] Lysine and threonine biosynthesis from aspartate contributes to Staphylococcus aureus growth in calf serum.2016
- Author(s)
  Oogai Y, Yamaguchi M, Kawada-Matsuo M, Sumitomo T, Kawabata S, Komatsuzawa H.
- Journal Title
  
  Appl Environ Microbiol.
  
  Volume: 82（２０） Pages: 6150-6157
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K11017
[Journal Article] The surface layer of Tannerella forsythia contributes to serum resistance and oral bacterial coaggregation.2013
- Author(s)
  Shimotahira N, Oogai Y, Kawada-Matsuo M, Yamada S, Fukutsuji K, Nagano K, Yoshimura F, Noguchi K, Komatsuzawa H.
- Journal Title
  
  Infection and Immunity
  
  Volume: Apr;81(4) Issue: 4 Pages: 1198-1206
- DOI
  10.1128/iai.00983-12
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25462868
[Journal Article] Involvement of the novel two-component NsrRS and LcrRS systems in distinct resistance pathways against nisin A and nukacin ISK-1 in Streptococcus mutans2013
- Author(s)
  Miki Kawada-Matsuo, Yuichi Oogai, Takeshi Zendo, Jun-ichi Nagao, Yukie Shibata, Yoshihisa Yamashita, Yoshitoshi Ogura, Tetsuya Hayashi, Kenji Sonomoto & Hitoshi Komatsuzawa
- Journal Title
  
  Appl. Eniviron. Microbiol
  
  Volume: 79 Issue: 15 Pages: 4751-4755
- DOI
  10.1128/aem.00780-13
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23380050, KAKENHI-PROJECT-25462868, KAKENHI-PROJECT-25861749
[Presentation] ミティス群レンサ球菌が産生する細胞外小胞の作用特性の解明2023
- Author(s)
  松本愛理，大貝悠一，住友倫子，中田匡宣
- Organizer
  第65回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-23K24521
[Presentation] ミティス群レンサ球菌におけるメンブランベシクルの産生とその作用特性2023
- Author(s)
  松本愛理，大貝悠一，田端厚之，住友倫子，中田匡宣
- Organizer
  九州微生物研究フォーラム 2023
- Data Source
  KAKENHI-PROJECT-22K19633
[Presentation] Fusobacterium nucleatumがFap2を介してAggregatibacter actinomycetemcomitansと共凝集する機構の解析2023
- Author(s)
  田中友三佳、大貝悠一、松本愛理、中田匡宣
- Organizer
  第65回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-23K09141
[Presentation] Fusobacterium nucleatumがFap2を介してAggregatibacter actinomycetemcomitansと共凝集する機構の解析2023
- Author(s)
  田中友三佳、大貝悠一、松本愛理、中田匡宣
- Organizer
  第65回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-20K09922
[Presentation] ミティス群レンサ球菌におけるメンブランベシクルの産生とその作用特性2023
- Author(s)
  松本愛理，大貝悠一，田端厚之，住友倫子，中田匡宣
- Organizer
  九州微生物研究フォーラム 2023
- Data Source
  KAKENHI-PROJECT-23K24521
[Presentation] ミティス群レンサ球菌が産生する細胞外小胞の作用特性の解明2023
- Author(s)
  松本愛理，大貝悠一，住友倫子，中田匡宣
- Organizer
  第65回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-22K19633
[Presentation] Fusobacterium nucleatumが Fap2を介してAggregatibacter actinomycetemcomitansと共凝集する機構の解析2023
- Author(s)
  田中友三佳，大貝悠一，松本愛理，中田匡宣
- Organizer
  第65回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-22K19633
[Presentation] Novel bacteriocin produced by Staphylococcus epidermidis active against nasal commensals2019
- Author(s)
  大貝悠一、小松澤均
- Organizer
  日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-17K11618
[Presentation] Aggregatibacter actinomycetemcomitansにおけるsmall RNAレパートリーとその種内多様性2018
- Author(s)
  大貝悠一
- Organizer
  題91回　細菌学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-17K11618
[Presentation] Analysis of nisin resistant strains of methicillin resistant Staphylococcus aureus2018
- Author(s)
  Kaoru Arii, Miki Kawada-Matsuo, Yuichi Oogai, Hitoshi Komatsuzawa
- Organizer
  第91回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-15K11017
[Presentation] Identification and expression analysis of small RNAs in Aggregatibacter actinomycetemcomitans2017
- Author(s)
  大貝悠一、後藤恭宏、小椋義俊、林哲也、小松澤均
- Organizer
  第90回日本細菌学会総会
- Place of Presentation
  仙台国際センター　展示棟　（宮城県・仙台市）
- Year and Date
  2017-03-19
- Data Source
  KAKENHI-PROJECT-15K20365
[Presentation] 黄色ブドウ球菌の Hmp は Streptococcus sanguinis の産生する過酸化水素感受性に関与する2016
- Author(s)
  大貝悠一，小松澤均
- Organizer
  第89回日本細菌学会総会
- Place of Presentation
  大阪国際交流センター（大阪府、大阪市）
- Year and Date
  2016-03-23
- Data Source
  KAKENHI-PROJECT-25462868
[Presentation] Aggregatibacter actinomycetemcomitansにおけるsmall RNAの同定2016
- Author(s)
  大貝悠一, 小松澤均
- Organizer
  第58回歯科基礎医学会学術大会
- Place of Presentation
  札幌コンベンションセンター　（北海道・札幌市）
- Year and Date
  2016-08-25
- Data Source
  KAKENHI-PROJECT-15K20365
[Presentation] ランチビオティクス耐性に関与するStreptococcus mutansの新規二成分制御系因子NsrRSとLcrRSの同定2015
- Author(s)
  松尾美樹、大貝悠一、善藤威史、小椋　義俊、林　哲也、園元謙二、小松澤均
- Organizer
  第19回　腸内細菌学会
- Place of Presentation
  東京都港区
- Year and Date
  2015-06-18
- Data Source
  KAKENHI-PROJECT-15K11017
[Presentation] F.nucleatum外膜タンパクの性状解析2010
- Author(s)
  大貝悠一
- Organizer
  第83回日本細菌学会総会
- Place of Presentation
  パシフィコ横浜(横浜市)
- Data Source
  KAKENHI-PROJECT-22791772
[Presentation] Fusobacterium nucleatum外膜タンパクの性状解析2010
- Author(s)
  大貝悠一、下田平直大、野口和行、小松澤均
- Organizer
  第83回日本細菌学会総会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-22791772
[Presentation] Effect of iron on the expression of virulence factors of S. aureus grown in serum2009
- Author(s)
  大貝悠一
- Organizer
  第82回日本細菌学会総会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2009-03-13
- Data Source
  KAKENHI-PROJECT-19041050
[Presentation] 血清中における黄色ブドウ球菌の病原性因子発現解析2008
- Author(s)
  大貝悠一
- Organizer
  第81回日本細菌学会総会
- Place of Presentation
  国立京都国際会館
- Year and Date
  2008-03-24
- Data Source
  KAKENHI-PROJECT-19041050

1. KOMATSUZAWA Hitoshi (90253088)

# of Collaborated Projects: 9 results

# of Collaborated Products: 11 results
2. Matsuo Miki (20527048)

# of Collaborated Projects: 6 results

# of Collaborated Products: 8 results
3. 中田匡宣 (90444497)

# of Collaborated Projects: 4 results

# of Collaborated Products: 9 results
4. KANBARA Kenji (60305141)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. 松本愛理 (00962424)

# of Collaborated Projects: 3 results

# of Collaborated Products: 6 results
6. 藤原環 (90274092)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. 菅井基行 (10201568)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. Hisatune Junzo

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. SUMITOMO Tomoko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 野口和行

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 川端重忠

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 山口雅也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 園元兼二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

OOGAI Yuichi 大貝 悠一

Oogai Yuichi 大貝 悠一

Research Projects

Research Products

Co-Researchers

歯周病原因細菌の口腔から全身への定着に関与する因子の研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of small RNAs associated with the expression of virulence genes and insertional sequence in periodontal pathogenPrincipal Investigator

Principal Investigator

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Identification of bioactive peptides producing by A. actinomycetemcomitansPrincipal Investigator

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Identification and virulence analysis of surface proteins in Aggregatibacter actinomycetemcomitansPrincipal Investigator

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Identification and characterization of the surface proteins in periodontal pathogensPrincipal Investigator

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OOGAI Yuichi 大貝悠一

Oogai Yuichi 大貝悠一