TAKEUCHI Toshifumi 竹内倫文

Researcher Number	40516176
Other IDs
Affiliation (Current)	2025: 公益財団法人微生物化学研究会, 微生物化学研究所, 主任研究員
Affiliation (based on the past Project Information) *help	2025: 公益財団法人微生物化学研究会, 微生物化学研究所, 主任研究員 2023: 公益財団法人微生物化学研究会, 微生物化学研究所, 主任研究員 2018 – 2022: 公益財団法人微生物化学研究会, 微生物化学研究所, 研究員 2017: 公益財団法人微生物化学研究会, 微生物化学研究所, 博士研究員
Review Section/Research Field	Principal Investigator Basic Section 37020:Chemistry and chemical methodology of biomolecules-related / Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related / Biomolecular chemistry
Keywords	Principal Investigator 天然物 / 構造最適化 / 作用機序解析 / 阻害剤 / エネルギー代謝 / 生理活性物質の探索 / 放線菌 / 化学生物学 / 全合成 / アルドール反応 … More / グラム陽性菌 / 触媒的不斉反応 / ペプチド / フマル酸水和酵素 / 生物活性物質の探索 / がんエネルギー代謝 / 分子プローブ / 天然物質 / 生理活性物質 / 天然物化学 Less

チアゾリル抗生物質ノカチアシン類の全合成と創薬リード化合物の探索Principal Investigator
- Principal Investigator
  
  竹内倫文
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  Microbial Chemistry Research Foundation
グルタミノリシスを標的とする抗腫瘍化合物の探索と化学生物学的な作用機序解明Principal Investigator
- Principal Investigator
  
  竹内倫文
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 37020:Chemistry and chemical methodology of biomolecules-related
- Research Institution
  Microbial Chemistry Research Foundation
Screening of glutaminolysis or glutamine metabolism inhibitorsPrincipal Investigator
- Principal Investigator
  
  TAKEUCHI Toshifumi
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 37020:Chemistry and chemical methodology of biomolecules-related
- Research Institution
  Microbial Chemistry Research Foundation
Screening for cancer metabolism inhibitor and identification of their mechanisms of actionPrincipal Investigator
- Principal Investigator
  
  TAKEUCHI Toshifumi
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biomolecular chemistry
- Research Institution
  Microbial Chemistry Research Foundation

All 2022 2021 2019 2018 2017

All Journal Article Presentation

[Journal Article] Micromonosporamide A with Glutamine-Dependent Cytotoxicity from Micromonospora sp. MM609M-173N6: Isolation, Stereochemical Determination, and Synthesis2021
- Author(s)
  Takeuchi Toshifumi、Hatano Masaki、Muramatsu Hideyuki、Kubota Yumiko、Sawa Ryuichi、Igarashi Masayuki
- Journal Title
  
  Organic Letters
  
  Volume: 23 Issue: 20 Pages: 7981-7985
- DOI
  10.1021/acs.orglett.1c02974
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K05726
[Journal Article] Design, Synthesis, and Biological Evaluation of EdAP, a 4′-Ethynyl-2′-Deoxyadenosine 5′-Monophosphate Analog, as a Potent Influenza a Inhibitor2019
- Author(s)
  Takeuchi Toshifumi、Sriwilaijaroen Nongluk、Sakuraba Ayako、Hayashi Ei、Kamisuki Shinji、Suzuki Yasuo、Ohrui Hiroshi、Sugawara Fumio
- Journal Title
  
  Molecules
  
  Volume: 24 Issue: 14 Pages: 2603-2603
- DOI
  10.3390/molecules24142603
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K05343, KAKENHI-PROJECT-19K05726, KAKENHI-PROJECT-15H05295
[Journal Article] Pyrenocine A induces monopolar spindle formation and suppresses proliferation of cancer cells2019
- Author(s)
  Myobatake Yusuke、Kamisuki Shinji、Tsukuda Senko、Higashi Tsunehito、Chinen Takumi、Takemoto Kenji、Hachisuka Masami、Suzuki Yuka、Takei Maya、Tsurukawa Yukine、Maekawa Hiroaki、Takeuchi Toshifumi、Matsunaga Tomoko M.、Sahara Hiroeki、Usui Takeo、Matsunaga Sachihiro、Sugawara Fumio
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 27 Issue: 23 Pages: 115149-115149
- DOI
  10.1016/j.bmc.2019.115149
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K05343, KAKENHI-PROJECT-18K11654, KAKENHI-PROJECT-19K05726, KAKENHI-ORGANIZER-15H05955, KAKENHI-PLANNED-15H05962, KAKENHI-PROJECT-19H03259
[Journal Article] Synthesis of nucleotide analogues, EFdA, EdA and EdAP, and the effect of EdAP on hepatitis B virus replication2019
- Author(s)
  Kamata Mai、Takeuchi Toshifumi、Hayashi Ei、Nishioka Kazane、Oshima Mizuki、Iwamoto Masashi、Nishiuchi Kota、Kamo Shogo、Tomoshige Shusuke、Watashi Koichi、Kamisuki Shinji、Ohrui Hiroshi、Sugawara Fumio、Kuramochi Kouji
- Journal Title
  
  Bioscience, Biotechnology, and Biochemistry
  
  Volume: 84 Issue: 2 Pages: 217-227
- DOI
  10.1080/09168451.2019.1673696
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K05343, KAKENHI-PROJECT-19K16326, KAKENHI-PROJECT-19K16672, KAKENHI-PROJECT-19K05726, KAKENHI-PROJECT-17H04085
[Journal Article] Direct Catalytic Asymmetric Aldol Reaction of α-Vinyl Acetamide2018
- Author(s)
  Toshifumi Takeuchi, Naoya Kumagai, Masakatsu Shibasaki
- Journal Title
  
  Journal of Organic Chemistry
  
  Volume: 83 Issue: 10 Pages: 5851-5858
- DOI
  10.1021/acs.joc.8b00743
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K13261, KAKENHI-PUBLICLY-16H01043, KAKENHI-PROJECT-17H03025
[Journal Article] ATP Depletion Assay Led to the Isolation of New 36-Membered Polyol Macrolides Deplelides A and B from Streptomyces sp. MM581-NF152017
- Author(s)
  Toshifumi Takeuchi , Masaki Hatano, Maya Umekita, Chigusa Hayashi, Shun-ichi Wada, Miho Nagayoshi, Ryuichi Sawa, Yumiko Kubota, Manabu Kawada, Masayuki Igarashi, Masakatsu Shibasaki
- Journal Title
  
  Organic Letters
  
  Volume: 19 Issue: 16 Pages: 4207-7210
- DOI
  10.1021/acs.orglett.7b01807
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K13261, KAKENHI-PROJECT-15K06888, KAKENHI-PROJECT-15K08013
[Presentation] グルタミン依存的な細胞増殖抑制活性を示すマイクロモノスポラミドAの単離・構造決定及び合成2022
- Author(s)
  竹内倫文、村松秀行、波多野和樹、久保田由美子、澤竜一、五十嵐雅之
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-19K05726
[Presentation] グルタミン依存的な細胞増殖抑制活性を示すマイクロモノスポラミドA：単離・構造決定及び合成2022
- Author(s)
  竹内倫文，波多野和樹，村松秀行，久保田由美子，澤竜一，五十嵐雅之
- Organizer
  第39回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-22K05341
[Presentation] グルタミン依存的な細胞増殖抑制活性を示すマイクロモノスポラミドA：単離・構造決定及び合成2022
- Author(s)
  竹内倫文，村松秀行，波多野和樹，久保田由美子，澤竜一，五十嵐雅之
- Organizer
  第39回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-19K05726
[Presentation] ATP枯渇活性を有する36員環ポリオール系マクロライド deplelide A及びBの単離・同定2019
- Author(s)
  竹内倫文，波多野和樹，梅北まや，林千草，和田俊一，永吉美穂，澤竜一，久保田由美子，川田学，五十嵐雅之，柴崎正勝
- Organizer
  第7回がんと代謝研究会in仙台
- Data Source
  KAKENHI-PROJECT-19K05726
[Presentation] Screening for the identification of cancer metabolism modulators2019
- Author(s)
  Toshifumi Takeuchi
- Organizer
  The 10th Japan-Korea Chemical Biology Symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K13261
[Presentation] Screening of Cancer Metabolism Inhibitor2019
- Author(s)
  Toshifumi Takeuchi
- Organizer
  The Joint Symposium of "10th Korea-Japan Chemical Biology Symposium" and "30th Meeting for New Drug Discovery" in Kanazawa
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K05726
[Presentation] Screening of Cancer Metabolism Inhibitor2018
- Author(s)
  Toshifumi Takeuchi
- Organizer
  The 9th Japan-Korea Chemical Biology Symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K13261
[Presentation] ATP枯渇活性を有する36員環マクロライドdeplelide A及びBの単離・同定2018
- Author(s)
  竹内倫文, 波多野和樹, 梅北まや, 林千草, 和田俊一, 永吉美穂, 澤竜一, 久保田由美子, 川田学, 五十嵐雅之, 柴﨑正勝
- Organizer
  日本薬学会第138年会（金沢）
- Data Source
  KAKENHI-PROJECT-17K13261
[Presentation] がんのエネルギー代謝を標的とする化合物の探索2017
- Author(s)
  竹内倫文
- Organizer
  2017年度生命科学系学会合同年次大会，ワークショップ（疾患関連分子の認識技術の革新）
- Invited
- Data Source
  KAKENHI-PROJECT-17K13261

1. KAMISUKI Shinji

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results

TAKEUCHI Toshifumi 竹内 倫文

Research Projects

Research Products

Co-Researchers

チアゾリル抗生物質ノカチアシン類の全合成と創薬リード化合物の探索Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

グルタミノリシスを標的とする抗腫瘍化合物の探索と化学生物学的な作用機序解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Screening of glutaminolysis or glutamine metabolism inhibitorsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Screening for cancer metabolism inhibitor and identification of their mechanisms of actionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Micromonosporamide A with Glutamine-Dependent Cytotoxicity from Micromonospora sp. MM609M-173N6: Isolation, Stereochemical Determination, and Synthesis2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Design, Synthesis, and Biological Evaluation of EdAP, a 4′-Ethynyl-2′-Deoxyadenosine 5′-Monophosphate Analog, as a Potent Influenza a Inhibitor2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Pyrenocine A induces monopolar spindle formation and suppresses proliferation of cancer cells2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Synthesis of nucleotide analogues, EFdA, EdA and EdAP, and the effect of EdAP on hepatitis B virus replication2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Direct Catalytic Asymmetric Aldol Reaction of α-Vinyl Acetamide2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] ATP Depletion Assay Led to the Isolation of New 36-Membered Polyol Macrolides Deplelides A and B from Streptomyces sp. MM581-NF152017

Author(s)

Journal Title

DOI

Data Source

[Presentation] グルタミン依存的な細胞増殖抑制活性を示すマイクロモノスポラミドAの単離・構造決定及び合成2022

Author(s)

Organizer

Data Source

[Presentation] グルタミン依存的な細胞増殖抑制活性を示すマイクロモノスポラミドA：単離・構造決定及び合成2022

Author(s)

Organizer

Data Source

[Presentation] グルタミン依存的な細胞増殖抑制活性を示すマイクロモノスポラミドA： 単離・構造決定及び合成2022

Author(s)

Organizer

Data Source

[Presentation] ATP枯渇活性を有する36員環ポリオール系マクロライド deplelide A及びBの単離・同定2019

Author(s)

Organizer

Data Source

[Presentation] Screening for the identification of cancer metabolism modulators2019

Author(s)

Organizer

Data Source

[Presentation] Screening of Cancer Metabolism Inhibitor2019

Author(s)

TAKEUCHI Toshifumi 竹内倫文

[Presentation] グルタミン依存的な細胞増殖抑制活性を示すマイクロモノスポラミドA：単離・構造決定及び合成2022