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TAKEUCHI Toshifumi  竹内 倫文

ORCIDConnect your ORCID iD *help
Researcher Number 40516176
Other IDs
Affiliation (Current) 2025: 公益財団法人微生物化学研究会, 微生物化学研究所, 主任研究員
Affiliation (based on the past Project Information) *help 2025: 公益財団法人微生物化学研究会, 微生物化学研究所, 主任研究員
2023: 公益財団法人微生物化学研究会, 微生物化学研究所, 主任研究員
2018 – 2022: 公益財団法人微生物化学研究会, 微生物化学研究所, 研究員
2017: 公益財団法人微生物化学研究会, 微生物化学研究所, 博士研究員
Review Section/Research Field
Principal Investigator
Basic Section 37020:Chemistry and chemical methodology of biomolecules-related / Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related / Biomolecular chemistry
Keywords
Principal Investigator
天然物 / 構造最適化 / 作用機序解析 / 阻害剤 / エネルギー代謝 / 生理活性物質の探索 / 放線菌 / 化学生物学 / 全合成 / アルドール反応 … More / グラム陽性菌 / 触媒的不斉反応 / ペプチド / フマル酸水和酵素 / 生物活性物質の探索 / がんエネルギー代謝 / 分子プローブ / 天然物質 / 生理活性物質 / 天然物化学 Less
  • Research Projects

    (4 results)
  • Research Products

    (15 results)
  • Co-Researchers

    (1 People)
  •  チアゾリル抗生物質ノカチアシン類の全合成と創薬リード化合物の探索Principal Investigator

    • Principal Investigator
      竹内 倫文
    • Project Period (FY)
      2025 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
    • Research Institution
      Microbial Chemistry Research Foundation
  •  グルタミノリシスを標的とする抗腫瘍化合物の探索と化学生物学的な作用機序解明Principal Investigator

    • Principal Investigator
      竹内 倫文
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 37020:Chemistry and chemical methodology of biomolecules-related
    • Research Institution
      Microbial Chemistry Research Foundation
  •  Screening of glutaminolysis or glutamine metabolism inhibitorsPrincipal Investigator

    • Principal Investigator
      TAKEUCHI Toshifumi
    • Project Period (FY)
      2019 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 37020:Chemistry and chemical methodology of biomolecules-related
    • Research Institution
      Microbial Chemistry Research Foundation
  •  Screening for cancer metabolism inhibitor and identification of their mechanisms of actionPrincipal Investigator

    • Principal Investigator
      TAKEUCHI Toshifumi
    • Project Period (FY)
      2017 – 2018
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Biomolecular chemistry
    • Research Institution
      Microbial Chemistry Research Foundation

All 2022 2021 2019 2018 2017

All Journal Article Presentation

  • [Journal Article] Micromonosporamide A with Glutamine-Dependent Cytotoxicity from Micromonospora sp. MM609M-173N6: Isolation, Stereochemical Determination, and Synthesis2021

    • Author(s)
      Takeuchi Toshifumi、Hatano Masaki、Muramatsu Hideyuki、Kubota Yumiko、Sawa Ryuichi、Igarashi Masayuki
    • Journal Title

      Organic Letters

      Volume: 23 Issue: 20 Pages: 7981-7985

    • DOI

      10.1021/acs.orglett.1c02974

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K05726
  • [Journal Article] Design, Synthesis, and Biological Evaluation of EdAP, a 4′-Ethynyl-2′-Deoxyadenosine 5′-Monophosphate Analog, as a Potent Influenza a Inhibitor2019

    • Author(s)
      Takeuchi Toshifumi、Sriwilaijaroen Nongluk、Sakuraba Ayako、Hayashi Ei、Kamisuki Shinji、Suzuki Yasuo、Ohrui Hiroshi、Sugawara Fumio
    • Journal Title

      Molecules

      Volume: 24 Issue: 14 Pages: 2603-2603

    • DOI

      10.3390/molecules24142603

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K05343, KAKENHI-PROJECT-19K05726, KAKENHI-PROJECT-15H05295
  • [Journal Article] Pyrenocine A induces monopolar spindle formation and suppresses proliferation of cancer cells2019

    • Author(s)
      Myobatake Yusuke、Kamisuki Shinji、Tsukuda Senko、Higashi Tsunehito、Chinen Takumi、Takemoto Kenji、Hachisuka Masami、Suzuki Yuka、Takei Maya、Tsurukawa Yukine、Maekawa Hiroaki、Takeuchi Toshifumi、Matsunaga Tomoko M.、Sahara Hiroeki、Usui Takeo、Matsunaga Sachihiro、Sugawara Fumio
    • Journal Title

      Bioorganic & Medicinal Chemistry

      Volume: 27 Issue: 23 Pages: 115149-115149

    • DOI

      10.1016/j.bmc.2019.115149

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K05343, KAKENHI-PROJECT-18K11654, KAKENHI-PROJECT-19K05726, KAKENHI-ORGANIZER-15H05955, KAKENHI-PLANNED-15H05962, KAKENHI-PROJECT-19H03259
  • [Journal Article] Synthesis of nucleotide analogues, EFdA, EdA and EdAP, and the effect of EdAP on hepatitis B virus replication2019

    • Author(s)
      Kamata Mai、Takeuchi Toshifumi、Hayashi Ei、Nishioka Kazane、Oshima Mizuki、Iwamoto Masashi、Nishiuchi Kota、Kamo Shogo、Tomoshige Shusuke、Watashi Koichi、Kamisuki Shinji、Ohrui Hiroshi、Sugawara Fumio、Kuramochi Kouji
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry

      Volume: 84 Issue: 2 Pages: 217-227

    • DOI

      10.1080/09168451.2019.1673696

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K05343, KAKENHI-PROJECT-19K16326, KAKENHI-PROJECT-19K16672, KAKENHI-PROJECT-19K05726, KAKENHI-PROJECT-17H04085
  • [Journal Article] Direct Catalytic Asymmetric Aldol Reaction of α-Vinyl Acetamide2018

    • Author(s)
      Toshifumi Takeuchi, Naoya Kumagai, Masakatsu Shibasaki
    • Journal Title

      Journal of Organic Chemistry

      Volume: 83 Issue: 10 Pages: 5851-5858

    • DOI

      10.1021/acs.joc.8b00743

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K13261, KAKENHI-PUBLICLY-16H01043, KAKENHI-PROJECT-17H03025
  • [Journal Article] ATP Depletion Assay Led to the Isolation of New 36-Membered Polyol Macrolides Deplelides A and B from Streptomyces sp. MM581-NF152017

    • Author(s)
      Toshifumi Takeuchi , Masaki Hatano, Maya Umekita, Chigusa Hayashi, Shun-ichi Wada, Miho Nagayoshi, Ryuichi Sawa, Yumiko Kubota, Manabu Kawada, Masayuki Igarashi, Masakatsu Shibasaki
    • Journal Title

      Organic Letters

      Volume: 19 Issue: 16 Pages: 4207-7210

    • DOI

      10.1021/acs.orglett.7b01807

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K13261, KAKENHI-PROJECT-15K06888, KAKENHI-PROJECT-15K08013
  • [Presentation] グルタミン依存的な細胞増殖抑制活性を示すマイクロモノスポラミドAの単離・構造決定及び合成2022

    • Author(s)
      竹内 倫文、村松 秀行、波多野 和樹、久保田 由美子、澤 竜一、五十嵐 雅之
    • Organizer
      日本薬学会第142年会
    • Data Source
      KAKENHI-PROJECT-19K05726
  • [Presentation] グルタミン依存的な細胞増殖抑制活性を示すマイクロモノスポラミドA:単離・構造決定及び合成2022

    • Author(s)
      竹内倫文,波多野和樹,村松秀行,久保田由美子,澤竜一,五十嵐雅之
    • Organizer
      第39回メディシナルケミストリーシンポジウム
    • Data Source
      KAKENHI-PROJECT-22K05341
  • [Presentation] グルタミン依存的な細胞増殖抑制活性を示すマイクロモノスポラミドA: 単離・構造決定及び合成2022

    • Author(s)
      竹内 倫文,村松 秀行,波多野 和樹,久保田 由美子,澤 竜一,五十嵐 雅之
    • Organizer
      第39回メディシナルケミストリーシンポジウム
    • Data Source
      KAKENHI-PROJECT-19K05726
  • [Presentation] ATP枯渇活性を有する36員環ポリオール系マクロライド deplelide A及びBの単離・同定2019

    • Author(s)
      竹内倫文,波多野和樹,梅北まや,林千草,和田俊一,永吉美穂,澤竜一,久保田由美子,川田学,五十嵐雅之,柴崎正勝
    • Organizer
      第7回がんと代謝研究会in仙台
    • Data Source
      KAKENHI-PROJECT-19K05726
  • [Presentation] Screening for the identification of cancer metabolism modulators2019

    • Author(s)
      Toshifumi Takeuchi
    • Organizer
      The 10th Japan-Korea Chemical Biology Symposium
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K13261
  • [Presentation] Screening of Cancer Metabolism Inhibitor2019

    • Author(s)
      Toshifumi Takeuchi
    • Organizer
      The Joint Symposium of "10th Korea-Japan Chemical Biology Symposium" and "30th Meeting for New Drug Discovery" in Kanazawa
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K05726
  • [Presentation] Screening of Cancer Metabolism Inhibitor2018

    • Author(s)
      Toshifumi Takeuchi
    • Organizer
      The 9th Japan-Korea Chemical Biology Symposium
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K13261
  • [Presentation] ATP枯渇活性を有する36員環マクロライドdeplelide A及びBの単離・同定2018

    • Author(s)
      竹内 倫文, 波多野 和樹, 梅北 まや, 林 千草, 和田 俊一, 永吉 美穂, 澤 竜一, 久保田 由美子, 川田 学, 五十嵐 雅之, 柴﨑正勝
    • Organizer
      日本薬学会第138年会(金沢)
    • Data Source
      KAKENHI-PROJECT-17K13261
  • [Presentation] がんのエネルギー代謝を標的とする化合物の探索2017

    • Author(s)
      竹内倫文
    • Organizer
      2017年度生命科学系学会合同年次大会,ワークショップ(疾患関連分子の認識技術の革新)
    • Invited
    • Data Source
      KAKENHI-PROJECT-17K13261
  • 1.  KAMISUKI Shinji
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 3 results

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