HONKURA Naoki 本藏直樹

… Alternative Names

Honkura Naoki 本藏直樹

本蔵直樹ホンクラナオキ

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Researcher Number	40518081
Other IDs	https://orcid.org/0000-0002-6018-867X
Affiliation (Current)	2025: 浜松医科大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help	2021 – 2024: 浜松医科大学, 医学部, 准教授 2019 – 2020: 浜松医科大学, 医学部, 助教 2009: 阪大, 生命機能研究科
Review Section/Research Field	Principal Investigator Basic Section 59040:Nutrition science and health science-related / Medium-sized Section 90:Biomedical engineering and related fields / Neurophysiology and muscle physiology Except Principal Investigator Basic Section 53020:Cardiology-related
Keywords	Principal Investigator 非線形光学顕微鏡 / 血管生理学 / 非侵襲生体光イメージング技術 / 生体代謝活動計測 / 多視点同時計測 / ヘモダイナミクス / 生体組織間シグナル伝達 / 生体組織間シグナル伝達機構 / 独立多視点顕微鏡 / 多視点同時記録 / 非侵襲生体光イメージング / 生体臓器間シグナル伝達 … More Except Principal Investigator … More トロンビン活性 / トロンボモジュリン / 可視化解析 / 線溶抑制機能不全 / 止血血栓 / 血栓止血 / 抗凝固薬 / 血管内皮細胞 / 向凝固薬 / トロンビン / トロンビン活性化線溶阻害因子 / 線溶抑制系 / 抗血栓療法 / 疑似血管モデル / リアルタイムイメージング解析 / 時空間的制御機構 / 血栓形成溶解 / 線溶 / 直接経口抗凝固薬 / プラスミノゲン集積 / 活性化血小板 / 線溶反応 / 蛍光顕微鏡 / トロンビン活性化線溶抑制因子 / トロンビン生成 / 血栓形成 / 血小板 / 線維素溶解（線溶） Less

血流分配を担う血管制御因子の非侵襲生体機能計測Principal Investigator
- Principal Investigator
  
  本藏直樹
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Hamamatsu University School of Medicine
Real-time imaging analysis of hemostatic thrombus stabilization and its failure
- Principal Investigator
  
  鈴木優子
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Hamamatsu University School of Medicine
Intravital Imaging for Nutrient Regulation in Vascular Endothelial Cells Interconnected with Local Cells MetabolismPrincipal Investigator
- Principal Investigator
  
  Honkura Naoki
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Hamamatsu University School of Medicine
高次生命現象を担う多臓器間シグナル伝達計測のための独立多視点同時高速画像法の開拓Principal Investigator
- Principal Investigator
  
  本藏直樹
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Review Section
  
  Medium-sized Section 90:Biomedical engineering and related fields
- Research Institution
  Hamamatsu University School of Medicine
Understanding in spatio-temporal regulation mechanism of thrombus formation and dissolution for realization of appropriate antithrombotic therapy
- Principal Investigator
  
  Suzuki Yuko
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Hamamatsu University School of Medicine
Development of intravital multi-field of view imaging for understanding biological communication among organsPrincipal Investigator
- Principal Investigator
  
  Honkura Naoki
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 90:Biomedical engineering and related fields
- Research Institution
  Hamamatsu University School of Medicine
光操作遺伝学を利用した運動制御の研究Principal Investigator
- Principal Investigator
  
  本蔵直樹
- Project Period (FY)
  2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurophysiology and muscle physiology
- Research Institution
  Osaka University

All 2024 2023 2022 2021 2020 2019

All Journal Article Presentation Book

[Book] 量子生命科学ハンドブック2024
- Author(s)
  本藏直樹
- Total Pages
  372
- Publisher
  エヌ・ティー・エス
- ISBN
  9784860438821
- Data Source
  KAKENHI-PROJECT-21K18323
[Book] 量子生命科学ハンドブック2024
- Author(s)
  本藏直樹
- Total Pages
  372
- Publisher
  エヌ・ティー・エス
- ISBN
  9784860438821
- Data Source
  KAKENHI-PROJECT-21H03352
[Journal Article] Visualization of Domain- and Concentration-Dependent Impact of Thrombomodulin on Differential Regulation of Coagulation and Fibrinolysis2023
- Author(s)
  Mochizuki Liina、Sano Hideto、Honkura Naoki、Masumoto Kazuma、Urano Tetsumei、Suzuki Yuko
- Journal Title
  
  Thrombosis and Haemostasis
  
  Volume: 123 Issue: 01 Pages: 016-026
- DOI
  10.1055/s-0042-1757407
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08153, KAKENHI-PROJECT-20K08710, KAKENHI-PROJECT-23K24431
[Journal Article] Pre-administration of a carboxypeptidase inhibitor enhances tPA-induced thrombolysis in mouse microthrombi: Evidence from intravital imaging analysis2022
- Author(s)
  Mathews Nitty Skariah、Suzuki Yuko、Honkura Naoki、Sano Hideto、Iwashita Toshihide、Urano Tetsumei
- Journal Title
  
  Thrombosis Research
  
  Volume: 210 Pages: 78-86
- DOI
  10.1016/j.thromres.2021.12.031
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08577, KAKENHI-PROJECT-19K22959, KAKENHI-PROJECT-21H03352, KAKENHI-PROJECT-21K18323, KAKENHI-PROJECT-21K06947, KAKENHI-PROJECT-20K08710
[Journal Article] Demonstration of Three Distinct High-Molecular-Weight Complexes between Plasminogen Activator Inhibitor Type 1 and Tissue-Type Plasminogen Activator2021
- Author(s)
  Ito Tae、Suzuki Yuko、Sano Hideto、Honkura Naoki、Castellino Francis J.、Urano Tetsumei
- Journal Title
  
  Thrombosis and Haemostasis
  
  Volume: 122 Issue: 03 Pages: 336-343
- DOI
  10.1055/a-1508-7919
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08577, KAKENHI-PROJECT-19K22959, KAKENHI-PROJECT-21H03352, KAKENHI-PROJECT-21K18323, KAKENHI-PROJECT-20K08710
[Journal Article] Fibrinolysis-resistant carbonylated fibrin detected in thrombi attached to the vascular wall of abdominal aortic aneurysms2020
- Author(s)
  Suzuki Yuko、Tanaka Hiroki、Horinouchi Takahiro、Sano Hideto、Honkura Naoki、Unno Naoki、Miwa Soichi、Urano Tetsumei
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 20728-20728
- DOI
  10.1038/s41598-020-77582-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08577, KAKENHI-PROJECT-20K08710, KAKENHI-PROJECT-19K22959, KAKENHI-PROJECT-18K06697
[Journal Article] Activated platelet-based inhibition of fibrinolysis via thrombin-activatable fibrinolysis inhibitor activation system2020
- Author(s)
  Suzuki Yuko、Sano Hideto、Mochizuki Liina、Honkura Naoki、Urano Tetsumei
- Journal Title
  
  Blood Advances
  
  Volume: 4 Issue: 21 Pages: 5501-5511
- DOI
  10.1182/bloodadvances.2020002923
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08577, KAKENHI-PROJECT-20K08710, KAKENHI-PROJECT-19K22959
[Journal Article] Noninvasive intravital imaging techniques: In order to capture genuine physiological responses2019
- Author(s)
  HONKURA Naoki
- Journal Title
  
  Japanese Journal of Thrombosis and Hemostasis
  
  Volume: 30 Issue: 3 Pages: 529-533
- DOI
  10.2491/jjsth.30.529
- NAID
  130007663072
- ISSN
  0915-7441, 1880-8808
- Language
  Japanese
- Data Source
  KAKENHI-PROJECT-19K22959
[Journal Article] Recognition of Plasminogen Activator Inhibitor Type 1 as the Primary Regulator of Fibrinolysis2019
- Author(s)
  Urano T, Suzuki Y, Iwaki T, Sano H, Honkura N, Castellino FJ.
- Journal Title
  
  Curr Drug Targets.
  
  Volume: 20 Issue: 16 Pages: 1695-1701
- DOI
  10.2174/1389450120666190715102510
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10666, KAKENHI-PROJECT-19K08577, KAKENHI-PROJECT-19K22959
[Presentation] Multidimensional nano-scale analyses for in vivo vascular cells2024
- Author(s)
  Naoki Honkura
- Organizer
  The 101st Annual Meeting of The Physiological Society of Japan
- Invited
- Data Source
  KAKENHI-PROJECT-21K18323
[Presentation] Multidimensional nano-scale analyses for in vivo vascular cells2024
- Author(s)
  Naoki Honkura
- Organizer
  The 101st Annual Meeting of The Physiological Society of Japan
- Invited
- Data Source
  KAKENHI-PROJECT-21H03352
[Presentation] 生体組織連続反応を捉えるための顕微技術の開発と応用2023
- Author(s)
  本藏直樹
- Organizer
  第８回血管生物医学会若手研究会
- Data Source
  KAKENHI-PROJECT-21H03352
[Presentation] 生体組織連続反応を捉えるための顕微技術の開発と応用2023
- Author(s)
  本藏直樹
- Organizer
  第８回血管生物医学会若手研究会
- Data Source
  KAKENHI-PROJECT-21K18323
[Presentation] 量子光学を巧みに用いた生体研究2022
- Author(s)
  本藏直樹
- Organizer
  第7回血管生物医学会若手研究会
- Data Source
  KAKENHI-PROJECT-21K18323
[Presentation] 生体顕微鏡を用いたレーザ惹起微小血栓溶解におけるcarboxypeptidase inhibitorの効果2022
- Author(s)
  鈴木優子、Nitty Mathws、佐野秀人、本藏直樹、浦野哲盟
- Organizer
  第44回日本血栓止血学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08577
[Presentation] 量子光学を巧みに用いた生体研究2022
- Author(s)
  本藏直樹
- Organizer
  第7回血管生物医学会若手研究会
- Data Source
  KAKENHI-PROJECT-21H03352
[Presentation] 量子光学を巧みに用いた生体研究2022
- Author(s)
  本藏直樹
- Organizer
  第7回血管生物医学会若手研究会
- Data Source
  KAKENHI-PROJECT-19K22959
[Presentation] 活性化血小板による線維素溶解（線溶）抑制機構2021
- Author(s)
  鈴木優子、望月里衣奈、佐野秀人、本藏直樹、浦野哲盟
- Organizer
  第68回中部日本生理学会
- Data Source
  KAKENHI-PROJECT-19K08577
[Presentation] Spatiotemporal regulation of fibrinolysis via thrombomodulin/thrombin/ TAFI system.2021
- Author(s)
  2.Yuko Suzuki, Hideto Sano, Naoki Honkura, Tetsumei Urano
- Organizer
  第43回日本血栓止血学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-19K08577
[Presentation] 生命を司る血液循環の定量生体イメージング解析2021
- Author(s)
  本藏直樹
- Organizer
  第64回日本神経化学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-21K18323
[Presentation] 生命を司る血液循環の定量生体イメージング解析2021
- Author(s)
  本藏直樹
- Organizer
  第64回日本神経化学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-19K22959
[Presentation] 非線形光学顕微鏡を用いた生体血流イメージング2021
- Author(s)
  本藏直樹
- Organizer
  第46回レーザ顕微鏡研究会
- Invited
- Data Source
  KAKENHI-PROJECT-21K18323
[Presentation] 非線形光学顕微鏡を用いた生体血流イメージング2021
- Author(s)
  本藏直樹
- Organizer
  第46回レーザ顕微鏡研究会
- Invited
- Data Source
  KAKENHI-PROJECT-19K22959
[Presentation] 生体細胞代謝に関与する血管物質交換の定量生体イメージング解析2021
- Author(s)
  本藏直樹
- Organizer
  第60回日本生体医工学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-21H03352
[Presentation] 血管物質交換によって駆動される生体内細胞活動の定量イメージング解析2021
- Author(s)
  本藏直樹
- Organizer
  第44回日本分子生物学会年
- Invited
- Data Source
  KAKENHI-PROJECT-21H03352
[Presentation] 血管物質交換によって駆動される生体内細胞活動の定量イメージング解析2021
- Author(s)
  本藏直樹
- Organizer
  第44回日本分子生物学会年
- Invited
- Data Source
  KAKENHI-PROJECT-19K22959
[Presentation] 非線形光学顕微鏡を用いた生体血流イメージング2021
- Author(s)
  本藏直樹
- Organizer
  第46回レーザ顕微鏡研究会
- Invited
- Data Source
  KAKENHI-PROJECT-21H03352
[Presentation] 生体細胞代謝に関与する血管物質交換の定量生体イメージング解析2021
- Author(s)
  本藏直樹
- Organizer
  第60回日本生体医工学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-19K22959
[Presentation] 血管物質交換によって駆動される生体内細胞活動の定量イメージング解析2021
- Author(s)
  本藏直樹
- Organizer
  第44回日本分子生物学会年
- Invited
- Data Source
  KAKENHI-PROJECT-21K18323
[Presentation] 生命を司る血液循環の定量生体イメージング解析2021
- Author(s)
  本藏直樹
- Organizer
  第64回日本神経化学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-21H03352
[Presentation] 生体細胞代謝に関与する血管物質交換の定量生体イメージング解析2021
- Author(s)
  本藏直樹
- Organizer
  第60回日本生体医工学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-21K18323
[Presentation] 非侵襲・非線形光学顕微鏡を用いた微小循環における物質放出の解明2020
- Author(s)
  本藏直樹
- Organizer
  第97回日本生理学会大会(誌上開催)
- Invited
- Data Source
  KAKENHI-PROJECT-19K22959
[Presentation] Intravital imaging analysis for the substance discharge in microcirculation using noninvasive and nonlinear optical microscopy2020
- Author(s)
  Naoki Honkura
- Organizer
  Gordon Research Conference(GRC): Plasminogen Activation and Extracellular Proteolysis
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22959
[Presentation] 定量画像解析により可能となった機能性血管種区分により同定された微小循環物質放出の仕組み2020
- Author(s)
  本藏直樹
- Organizer
  第93回日本生化学会
- Invited
- Data Source
  KAKENHI-PROJECT-19K22959
[Presentation] 非侵襲・非線形光学顕微鏡を用いた微小循環における物質放出の解明2020
- Author(s)
  本藏直樹
- Organizer
  第97回日本生理学会
- Invited
- Data Source
  KAKENHI-PROJECT-19K22959
[Presentation] コロナ病態の理解に繋が生体血管内皮傷害後の血管障害・修復機構とは？～真実は生体の中でしか分からない～2020
- Author(s)
  本藏直樹
- Organizer
  第6回血管生物若手研究会
- Data Source
  KAKENHI-PROJECT-19K22959
[Presentation] Intravital imaging analysis for the substance discharge in microcirculation with noninvasive optical microscopy2020
- Author(s)
  本藏直樹
- Organizer
  第42回日本血栓止血学会
- Invited
- Data Source
  KAKENHI-PROJECT-19K22959
[Presentation] Intravital imaging analysis for the substance discharge in microcirculation using noninvasive and nonlinear optical microscopy2020
- Author(s)
  本藏直樹
- Organizer
  Gordon Research Conference(GRC): Plasminogen Activation and Extracellular Proteolysis
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22959
[Presentation] Modulation of thrombin generation or thrombin activity on activated platelets surface largely affected TAFI-dependent regulation of fibrinolysis.2020
- Author(s)
  Suzuki Y, Sano H, Honkura N, Urano T
- Organizer
  The XXVII Congress of the International Society on Thrombosis and Hemostasis (ISTH),
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08577
[Presentation] トロンビンによるTAFIの活性化を介した線溶阻害作用のリアルタイムイメージング解析2020
- Author(s)
  鈴木優子，佐野秀人, 本藏直樹, 浦野哲盟
- Organizer
  第82回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08577
[Presentation] Advanced intravital imaging techniques for vessel discrimination and assessment of physiological vascular dynamics in in vivo2019
- Author(s)
  Naoki Honkura
- Organizer
  The 19th Hamamatsu-Kyungpook Joint Medical Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22959
[Presentation] 非線形光学顕微鏡を用いた生体物質交換の解析2019
- Author(s)
  本藏直樹
- Organizer
  第170回 n-bio セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-19K22959
[Presentation] Application of nonlinear optical effects in intravital imaging to reveal functional blood circuit.2019
- Author(s)
  Naoki Honkura
- Organizer
  第27回日本血管生物医学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-19K22959
[Presentation] 非線形光学顕微鏡を用いた生体血管分別法およびその構造機能解析2019
- Author(s)
  本藏直樹
- Organizer
  第66回中部生理学会
- Data Source
  KAKENHI-PROJECT-19K22959
[Presentation] 最尖端生体光学イメージング技術を用いた新規血管分類法と動的な血管機能の評価2019
- Author(s)
  本藏直樹
- Organizer
  第41回日本血栓止血学会学術集会
- Data Source
  KAKENHI-PROJECT-19K22959
[Presentation] Intravital imaging with nonlinear optical effects has shown up functional blood circuit2019
- Author(s)
  Naoki Honkura
- Organizer
  第21回高柳健次郎記念シンポジウム
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22959

1. Suzuki Yuko (20345812)

# of Collaborated Projects: 4 results

# of Collaborated Products: 10 results
2. 佐野秀人 (80623842)

# of Collaborated Projects: 2 results

# of Collaborated Products: 10 results
3. 浦野哲盟 (50193967)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
4. 諸岡七美 (40817110)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. IWAKI Takayuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

HONKURA Naoki 本藏 直樹

Honkura Naoki 本藏 直樹

本蔵 直樹 ホンクラ ナオキ

Research Projects

Research Products

Co-Researchers

血流分配を担う血管制御因子の非侵襲生体機能計測Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Real-time imaging analysis of hemostatic thrombus stabilization and its failure

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Intravital Imaging for Nutrient Regulation in Vascular Endothelial Cells Interconnected with Local Cells MetabolismPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

高次生命現象を担う多臓器間シグナル伝達計測のための独立多視点同時高速画像法の開拓Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Understanding in spatio-temporal regulation mechanism of thrombus formation and dissolution for realization of appropriate antithrombotic therapy

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of intravital multi-field of view imaging for understanding biological communication among organsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

光操作遺伝学を利用した運動制御の研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 量子生命科学ハンドブック2024

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Book] 量子生命科学ハンドブック2024

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Journal Article] Visualization of Domain- and Concentration-Dependent Impact of Thrombomodulin on Differential Regulation of Coagulation and Fibrinolysis2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Pre-administration of a carboxypeptidase inhibitor enhances tPA-induced thrombolysis in mouse microthrombi: Evidence from intravital imaging analysis2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Demonstration of Three Distinct High-Molecular-Weight Complexes between Plasminogen Activator Inhibitor Type 1 and Tissue-Type Plasminogen Activator2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Fibrinolysis-resistant carbonylated fibrin detected in thrombi attached to the vascular wall of abdominal aortic aneurysms2020

Author(s)

Journal Title

DOI

Data Source

HONKURA Naoki 本藏直樹

Honkura Naoki 本藏直樹

本蔵直樹ホンクラナオキ