HARADA Naozumi 原田直純

Researcher Number	40520961
Affiliation (based on the past Project Information) *help	2016 – 2018: 三重大学, 医学系研究科, 特任講師(研究担当) 2012 – 2013: 三重大学, 医学(系)研究科(研究院), リサーチアソシエイト
Review Section/Research Field	Principal Investigator Biomedical engineering/Biological material science Except Principal Investigator Tumor therapeutics
Keywords	Principal Investigator マクロファージ / がんワクチン / リンパ節 / デリバリーシステム / ナノゲル Except Principal Investigator ワクチン / 免疫応答 / 複合免疫療法 / 変異抗原

Development of effective combined immunotherapies by using a novel immune response detection method
- Principal Investigator
  
  Miyahara Yoshihiro
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor therapeutics
- Research Institution
  Mie University
Analysis of immunotransporter function of the hydrophobized polysaccharide-based nanogel and its application to cancer therapyPrincipal Investigator
- Principal Investigator
  
  HARADA Naozumi
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  Mie University

All 2019 2017 2014 2013 2012

All Journal Article Presentation Book Patent

[Book] バイオ医薬品2013
- Author(s)
  原田直純、珠玖洋
- Publisher
  化学同人
- Data Source
  KAKENHI-PROJECT-24650259
[Journal Article] Antigen delivery targeted to tumor-associated macrophages overcomes tumor immune resistance2019
- Author(s)
  Muraoka Daisuke、Seo Naohiro、Hayashi Tae、Tahara Yoshiro、Fujii Keisuke、Tawara Isao、Miyahara Yoshihiro、Okamori Kana、Yagita Hideo、Imoto Seiya、Yamaguchi Rui、Komura Mitsuhiro、Miyano Satoru、Goto Masahiro、Sawada Shin-ichi、Asai Akira、Ikeda Hiroaki、Akiyoshi Kazunari、Harada Naozumi、Shiku Hiroshi
- Journal Title
  
  Journal of Clinical Investigation
  
  Volume: 129 Issue: 3 Pages: 1278-1294
- DOI
  10.1172/jci97642
- NAID
  120006987781
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07222, KAKENHI-PROJECT-18K19584, KAKENHI-PROJECT-18H02559, KAKENHI-PROJECT-18H02872, KAKENHI-PROJECT-18H03328, KAKENHI-PROJECT-18K19474, KAKENHI-PROJECT-16H06369, KAKENHI-PROJECT-16K07168
[Journal Article] Identification of an immunogenic neo-epitope encoded by mouse sarcoma using CXCR3 ligand mRNAs as sensors2017
- Author(s)
  Fujii K, Miyahara Y, Harada N, Muraoka D, Komura M, Yamaguchi R, Yagita H, Nakamura J, Sugino S, Okumura S, Imoto S, Miyano S, Shiku H
- Journal Title
  
  OncoImmunology
  
  Volume: 印刷中 Issue: 5 Pages: e1306617-e1306617
- DOI
  10.1080/2162402x.2017.1306617
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H02775, KAKENHI-PROJECT-16K07168
[Journal Article] Establishment of animal models to analyze the kinetics and distribution of human tumor antigen-specific CD8+ T cells2013
- Author(s)
  Muraoka D, Nishikawa H, Noguchi T, Wang L, Harada N, Sato E, Luescher I, Nakayama E, Kato T, Shiku H
- Journal Title
  
  Vaccine
  
  Volume: 31(17) Issue: 17 Pages: 2110-2118
- DOI
  10.1016/j.vaccine.2013.02.056
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23300354, KAKENHI-PROJECT-24650259, KAKENHI-PROJECT-25430161, KAKENHI-PROJECT-25670553
[Journal Article] Dose-dependent effects of NY-ESO-1 protein vaccine complexed with cholesteryl pullulan (CHP-NY-ESO-1) on immune responses and survival benefits of esophageal cancer patients2013
- Author(s)
  Kageyama S, Wada H, Muro K, Niwa Y, Ueda S, Miyata H, Takiguchi S, Sugino SH, Miyahara Y, Ikeda H, Imai N, Sato E, Yamada T, Osako M, Ohnishi M, Harada N, Hishida T, Doki Y, Shiku H
- Journal Title
  
  Journal of translational medicine
  
  Volume: 5;11 Issue: 1 Pages: 246-246
- DOI
  10.1186/1479-5876-11-246
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23501284, KAKENHI-PROJECT-24390300, KAKENHI-PROJECT-24591939, KAKENHI-PROJECT-24591965, KAKENHI-PROJECT-24650259
[Patent] がん治療用ワクチン製剤2012
- Inventor(s)
  原田直純,村岡大輔,秋吉一成,珠玖洋
- Industrial Property Rights Holder
  三重大学・東京医科歯科大学
- Industrial Property Rights Type
  特許
- Filing Date
  2012-08-30
- Overseas
- Data Source
  KAKENHI-PROJECT-24650259
[Presentation] A Novel Cancer Vaccine with Nanogel-based Antigen Transporter and Sequence-optimized Long Peptide Antigen2014
- Author(s)
  Naozumi Harada1,2, Daisuke Muraoka1,2, Tae Hayashi1,2, Fumiyasu Momose1, Yoshiro Tahara3,4, Shin-ichi Sawada3,4, Kazunari Akiyoshi3,4, and Hiroshi Shiku1
- Organizer
  ITOC-1
- Place of Presentation
  ドイツ　ミュンヘン
- Data Source
  KAKENHI-PROJECT-24650259
[Presentation] A Novel Cancer Vaccine with Nanogel-based Antigen Transporter and Sequence-optimized Long Peptide Antigen2014
- Author(s)
  Harada N, Muraoka D, Hayashi T, Momose F, Tahara Y, Sawada S, Akiyoshi K, Shiku H.
- Organizer
  ITOC-1
- Place of Presentation
  ミュンヘン,ドイツ
- Data Source
  KAKENHI-PROJECT-24650259
[Presentation] CHPナノゲルはロングペプチド抗原をリンパ節内のマクロファージに抗原提示させる2013
- Author(s)
  村岡大輔,原田直純,林妙,百瀬文康,澤田晋一,秋吉一成,珠玖洋
- Organizer
  日本がん免疫学会
- Place of Presentation
  宇部
- Data Source
  KAKENHI-PROJECT-24650259
[Presentation] Macrophage is a good target as antigen presenting cell to induce strong immune responses elicited with administration of vaccination antigen and immunological adjuvant2013
- Author(s)
  Muraoka D, Harada N, Hayashi T, Momose F, Sawada S, Akiyoshi K, Shiku H
- Organizer
  日本免疫学会
- Place of Presentation
  千葉
- Data Source
  KAKENHI-PROJECT-24650259
[Presentation] Peptide Sequence Design and Delivery System Are Critical for the Immunogenicity of Long Peptide-Based Cancer Vaccines2013
- Author(s)
  Daisuke Muraoka1,3, Naozumi Harada1,3, Tae Hayashi1,3, Kazunari Akiyoshi4, and Hiroshi Shiku1,2
- Organizer
  日本癌学会
- Place of Presentation
  横浜市
- Data Source
  KAKENHI-PROJECT-24650259
[Presentation] 抗原デリバリーシステム・CHPナノゲルはワクチン抗原をリンパ節内の抗原提示細胞に高効率輸送しワクチン性能を向上させる2013
- Author(s)
  原田直純,村岡大輔,林妙,澤田晋一,秋吉一成,珠玖洋
- Organizer
  日本DDS学会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-24650259
[Presentation] Peptide Sequence Design and Delivery System Are Critical for the Immunogenicity of Long Peptide-Based Cancer Vaccines2013
- Author(s)
  Muraoka D, Harada N, Hayashi T, Akiyoshi K, Shiku, H.
- Organizer
  日本癌学会
- Place of Presentation
  パシフィコ横浜,横浜
- Data Source
  KAKENHI-PROJECT-24650259
[Presentation] 抗原デリバリーシステム・CHPナノゲルはワクチン抗原をリンパ節内の抗原提示細胞2013
- Author(s)
  原田直純、村岡大輔、林妙、澤田晋一、秋吉一成、珠玖洋
- Organizer
  日本DDS学会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-24650259
[Presentation] マクロファージ指向型がんワクチンの有用性検討2013
- Author(s)
  村岡大輔1,3、原田直純1,3、林妙1,3、百瀬文康1、澤田晋一 4、秋吉一成4、珠玖洋1,2
- Organizer
  日本がん免疫学会
- Place of Presentation
  宇部市
- Data Source
  KAKENHI-PROJECT-24650259
[Presentation] Macrophage is a good target as antigen presenting cell to induce strong immune responses elicted with administration of vaccination antigen and immunological adjuvant2013
- Author(s)
  Daisuke Muraoka1,3, Naozumi Harada1,3, Tae Hayashi1,3, Momose Fumiyasu2, Shin-ichi Sawada4, Kazunari Akiyoshi4, and Hiroshi Shiku1,2
- Organizer
  日本免疫学会
- Place of Presentation
  千葉市
- Data Source
  KAKENHI-PROJECT-24650259
[Presentation] ワクチン抗原のCHPナノゲル複合体化によるリンパ節輸送の促進と抗腫瘍免疫応答の改善2012
- Author(s)
  村岡大輔、原田直純、林妙、吉見公志、澤田晋一、秋吉一成、珠玖洋
- Organizer
  日本がん免疫学会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-24650259
[Presentation] ワクチン抗原のCHPナノゲル複合体化によるリンパ節輸送の促進と抗腫瘍免疫応答の改善2012
- Author(s)
  村岡大輔,原田直純,林妙,吉見公志,澤田晋一,秋吉一成,珠玖洋
- Organizer
  日本がん免疫学会
- Place of Presentation
  北海道大学,札幌.
- Data Source
  KAKENHI-PROJECT-24650259
[Presentation] Control of in vivo spatiotemporal dynamics of antigen and adjuvant by a delivery system CHP nanogel markedly improves the immunogenicity and antitumor efficacy of long peptide cancer vaccine2012
- Author(s)
  Muraoka D, Harada N, Hayashi T, Sawada S, Akiyoshi K, Shiku H.
- Organizer
  the AACR Special Conference, Tumor Immunology : Multidisciplinary Science Driving Basic and Clinical Advances
- Place of Presentation
  マイアミ,米国
- Data Source
  KAKENHI-PROJECT-24650259
[Presentation] ワクチン抗原のCHPナノゲル複合体化によるリンパ節輸送の促進と抗腫瘍免疫応答の改善2012
- Author(s)
  吉見公志,村岡大輔,原田直純,林妙,秋吉一成,珠玖洋
- Organizer
  日本癌学会
- Place of Presentation
  ホテルロイトン札幌,札幌.
- Data Source
  KAKENHI-PROJECT-24650259
[Presentation] ワクチン抗原のCHPナノゲル複合体化によるリンパ節輸送の促進と抗腫瘍免疫応答の改善2012
- Author(s)
  吉見公志、村岡大輔、原田直純、林妙、秋吉一成、珠玖洋
- Organizer
  日本癌学会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-24650259
[Presentation] Long Peptides Complexed with A Novel Delivery Sytem CHP Nanogel Leads to the Improved Vaccine-induced Specific Immune2012
- Author(s)
  Naozumi Harada, Daisuke Muraoka, Tae Hayashi, Koji Yoshimi, Shin-ichi Sawada, Kazunari Akiyoshi and Hiroshi Shiku
- Organizer
  CIMT
- Place of Presentation
  ドイツ
- Data Source
  KAKENHI-PROJECT-24650259
[Presentation] Long Peptides Complexed with A Novel Delivery System CHP Nanogel Leads to the Improved Vaccine-induced Specific Immune Responses with CpG oligo DNA or poly-I2012
- Author(s)
  Harada N, Muraoka D, Hayashi T, Yoshimi K, Sawada S, Akiyoshi K, Shiku H.
- Organizer
  C RNAThe Association for Cancer Immunotherapy (CIMT) 2012 Annual Meeting
- Place of Presentation
  Rheingoldhalle Congress Center, Mainz, Germany.
- Data Source
  KAKENHI-PROJECT-24650259

1. Miyahara Yoshihiro (10582083)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
2. 西川博嘉

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 井元清哉

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 村岡大輔

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

HARADA Naozumi 原田 直純

Research Projects

Research Products

Co-Researchers

Development of effective combined immunotherapies by using a novel immune response detection method

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of immunotransporter function of the hydrophobized polysaccharide-based nanogel and its application to cancer therapyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] バイオ医薬品2013

Author(s)

Publisher

Data Source

[Journal Article] Antigen delivery targeted to tumor-associated macrophages overcomes tumor immune resistance2019

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Identification of an immunogenic neo-epitope encoded by mouse sarcoma using CXCR3 ligand mRNAs as sensors2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Establishment of animal models to analyze the kinetics and distribution of human tumor antigen-specific CD8+ T cells2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Dose-dependent effects of NY-ESO-1 protein vaccine complexed with cholesteryl pullulan (CHP-NY-ESO-1) on immune responses and survival benefits of esophageal cancer patients2013

Author(s)

Journal Title

DOI

Data Source

[Patent] がん治療用ワクチン製剤2012

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Filing Date

Data Source

[Presentation] A Novel Cancer Vaccine with Nanogel-based Antigen Transporter and Sequence-optimized Long Peptide Antigen2014

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] A Novel Cancer Vaccine with Nanogel-based Antigen Transporter and Sequence-optimized Long Peptide Antigen2014

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] CHPナノゲルはロングペプチド抗原をリンパ節内のマクロファージに抗原提示させる2013

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] Macrophage is a good target as antigen presenting cell to induce strong immune responses elicited with administration of vaccination antigen and immunological adjuvant2013

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] Peptide Sequence Design and Delivery System Are Critical for the Immunogenicity of Long Peptide-Based Cancer Vaccines2013

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] 抗原デリバリーシステム・CHPナノゲルはワクチン抗原をリンパ節内の抗原提示細胞に高効率輸送しワクチン性能を向上させる2013

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] Peptide Sequence Design and Delivery System Are Critical for the Immunogenicity of Long Peptide-Based Cancer Vaccines2013

Author(s)

Organizer

HARADA Naozumi 原田直純