TANAKA YOICHI 田中庸一

… Alternative Names

Yoichi Tanaka 田中庸一

TANAKA Yoichi 田中庸一

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Researcher Number	40525341
Other IDs	https://orcid.org/0000-0002-8949-1293
Affiliation (Current)	2025: 国立医薬品食品衛生研究所, 医薬安全科学部, 室長
Affiliation (based on the past Project Information) *help	2025: 国立医薬品食品衛生研究所, 医薬安全科学部, 室長 2020 – 2023: 国立医薬品食品衛生研究所, 医薬安全科学部, 主任研究官 2017 – 2019: 北里大学, 薬学部, 講師 2015 – 2016: 北里大学, 薬学部, 助教 2010 – 2012: 北里大学, 薬学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 47060:Clinical pharmacy-related / Medical pharmacy Except Principal Investigator Pediatrics
Keywords	Principal Investigator 小児白血病 / 6-メルカプトプリン / 白血病 / L-アスパラギナーゼ / 小児急性リンパ性白血病 / 遺伝子多型 / メルカプトプリン / 小児血液がん / 過敏症 / IgE … More / IgG / 抗体 / アスパラギナーゼ / 濃度 / 代謝物 / DNA-dTG / deoxy thioguanine / LC-MS/MS / NUDT15 / deoxy thioguanosine / DNA / 小児 / 有害事象 / メトトレキセート / 毒性 / 遺伝要因 / 薬剤感受性 / 感受性 / 抗悪性腫瘍薬 / ゲノムワイド関連解析 / 薬物投与量 / MTHFR / ITPA / TPMT / Methylenetetrahydrofolate reductase / Inosine triphosphate pyrophosphatase / Thiopurine S-methyl transferase / ファーマコジェノミクス / 副作用 / ファーマコジェネティクス … More Except Principal Investigator 小児腫瘍学 / ゲノム薬理学 / 薬理ゲノム学 / 遺伝子多型 / 治療毒性 / 白血病 / 小児 Less

NUDT15ハプロタイプによる酵素活性変動の要因と基質薬物の構造による影響の解明Principal Investigator
- Principal Investigator
  
  田中庸一
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  National Institute of Health Sciences
Evaluation of anti-L-asparaginase antibody and difference of antibody production in each patientPrincipal Investigator
- Principal Investigator
  
  Tanaka Yoichi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  National Institute of Health Sciences
Personalized therapy for mercaptopurine by measuring metabolites in DNA in children with leukemiaPrincipal Investigator
- Principal Investigator
  
  Tanaka Yoichi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  National Institute of Health Sciences
  Kitasato University
Elucidation of gene polymorphisms related with adverse events in the treatment of childhood acute lymphoblastic leukemia
- Principal Investigator
  
  Manabe Atsushi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Hokkaido University
  St. Luke's International University
Evaluation of genetic factors for drug sensitivity in childhood leukemia by genome wide association analysisPrincipal Investigator
- Principal Investigator
  
  Yoichi Tanaka
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Kitasato University
Pharmacogenetics of 6-mercaptopurine maintenance therapy for acutelymphoblastic leukemia in JapanesePrincipal Investigator
- Principal Investigator
  
  TANAKA Yoichi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Kitasato University

All 2021 2020 2019 2018 2017 2016 2013 2012 2011

All Journal Article Presentation

[Journal Article] Regional evaluation of childhood acute lymphoblastic leukemia genetic susceptibility loci among Japanese2018
- Author(s)
  Urayama Kevin Y.、Takagi Masatoshi、Kawaguchi Takahisa、Matsuo Keitaro、Tanaka Yoichi、Ayukawa Yoko、Arakawa Yuki、Hasegawa Daisuke、Yuza Yuki、Kaneko Takashi、Noguchi Yasushi、Taneyama Yuichi、Ota Setsuo、Inukai Takeshi、Yanagimachi Masakatsu、Keino Dai、Koike Kazutoshi、Toyama Daisuke、Inazawa Johji 他16名
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Issue: 1 Pages: 789-789
- DOI
  10.1038/s41598-017-19127-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-15H05908, KAKENHI-PROJECT-17H04224, KAKENHI-PROJECT-15K09645, KAKENHI-PROJECT-16K14630, KAKENHI-PROJECT-17K10129, KAKENHI-PROJECT-15K18932
[Journal Article] Interaction between NUDT15 and ABCC4 variants enhances intolerability of 6-mercaptopurine in Japanese patients with childhood acute lymphoblastic leukemia2018
- Author(s)
  Tanaka Y, Nakadate H, Kondoh K, Nakamura K, Koh K, Manabe A
- Journal Title
  
  The Pharmacogenomics Journal
  
  Volume: 18 Issue: 2 Pages: 275-280
- DOI
  10.1038/tpj.2017.12
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K10129, KAKENHI-PROJECT-15K18932
[Journal Article] The activity of the inosine triphosphate pyrophosphatase affects toxicity of 6-mercaptopurine during maintenance therapy for acute lymphoblastic leukemia in Japanese children2012
- Author(s)
  Tanaka Y, Manabe A, Nakadate H, Kondoh K, Nakamura K, Koh K, Utano T, Kikuchi A, Komiyama T
- Journal Title
  
  Leukemia research
  
  Volume: 36 Issue: 5 Pages: 560-564
- DOI
  10.1016/j.leukres.2011.11.015
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790170
[Presentation] 6-メルカプトプリン投与小児白血病患者におけるDNA中 deoxythioguanosineの定量と有害事象との関連性に関する検討2021
- Author(s)
  田中庸一、小野林太郎、足洗美穂、細谷要介、櫻井彩子、渡邊敦、長谷川大輔、斎藤嘉朗
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-18K06756
[Presentation] Efficacy of mercaptopurine sensitivity test after long-term exposure of leukemia cells2020
- Author(s)
  Somazu S, Tanaka Y, Thao N, Keiko Kagami K, Kasai S, Tamai M, Murakami Y, Watanabe A, Akahane K, Sato H, Kojika S, Goi K, Inukai T
- Organizer
  第82会日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-18K06756
[Presentation] Association of NUDT15 gene polymorphism with cellular metabolism of thiopurine in BCP-ALL cell lines2019
- Author(s)
  Shinpei Somazu, Yoichi Tanaka, Masako Abe, Keiko Kagami, Daisuke Harama, Yasushi Murakami, Atsushi Watanabe, Koushi Akahane, Kumiko Goi, Takaya Moriyama, Jun Yang , Takeshi Inukai
- Organizer
  第61回日本小児血液・がん学会学術集会
- Data Source
  KAKENHI-PROJECT-18K06756
[Presentation] NUDT15 genetic variation is the strongest predictive marker of tolerance to 6-mercaptopurine in Japanese childhood ALL patients: A genome-wide association study.2019
- Author(s)
  Tanaka Y, Urayama K, Mori M, Hasegawa D, Noguchi Y, Yanagimachi M, Keino D, Ota S, Akabane K, Hangai M, Kawaguchi T, Takagi M, Koh K, Matsuda F, Manabe A.
- Organizer
  アメリカ血液学会（ASH）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10129
[Presentation] 患者の年齢と肥満度の6-メルカプトプリン投与量への影響2018
- Author(s)
  田中庸一、康　勝好、真部　淳
- Organizer
  第60回日本小児血液・がん学会学術集会
- Data Source
  KAKENHI-PROJECT-17K10129
[Presentation] 1.小児ALLにおける高用量メトトレキサート療法時の薬物クリアランスへ影響を及ぼす因子の検討2018
- Author(s)
  田中庸一、康　勝好、真部　淳
- Organizer
  第80回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-17K10129
[Presentation] NUDT15 ハプロタイプの6-メルカプトプリン感受性への影響2018
- Author(s)
  田中庸一、近藤健介、康　勝好、尾鳥勝也、真部　淳
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-15K18932
[Presentation] 3.Tolerable dose of 6-mercaptopurine and prognostic impact of NUDT15-deficient genotype in childhood acute lymphoblastic leukemia2018
- Author(s)
  Tanaka Y, Kato M, Arakawa Y, Hasegawa D, Fujimura J, Keino D, Sato A, Ueda T, Taneyama Y, Takagi M, Yamamoto M, Matsuoka M, Hino M, Hori H, Koh K, Moriyama T, Yeoh A, Yang JJ, Manabe A.
- Organizer
  60th ASH Annual Meeting & Exposition
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10129
[Presentation] The association between plasma methotrexate concentration and genetic variant in high-dose methotrexate therapy for childhood acute lymphoblastic leukemia2017
- Author(s)
  Yoichi Tanaka, Kevin Urayama, Makiko Mori, Daisuke Hasegawa, Koshi Akahane, Setsuo Ota, Katsuyoshi Koh, Atsushi Manabe
- Organizer
  第５９回日本小児血液・がん学会学術集会
- Data Source
  KAKENHI-PROJECT-15K18932
[Presentation] 日本人小児ALLのL-アスパラギナーゼアレルギー発現におけるNFATC2 rs6021191多型の影響2016
- Author(s)
  田中庸一、Kevin Urayama、森麻希子、長谷川大輔、石丸紗恵、寺田和樹、柳町昌克、太田節雄、高橋浩之、外山大輔、慶野　大、森脇浩一、高木正稔、藤村純也、関中悠仁、中村こずえ、佐藤雄也、小原　明、康　勝好、真部　淳
- Organizer
  第58回日本小児血液・がん学会学術集会
- Place of Presentation
  品川プリンスホテル（東京都港区）
- Year and Date
  2016-12-15
- Data Source
  KAKENHI-PROJECT-15K18932
[Presentation] The association between L-asparaginase hypersensitivity and genetic variants in Japanese childhood ALL patients2016
- Author(s)
  Tanaka Y, Urayama KY, Kawaguchi T, Mori M, Hasegawa D, Ishimaru S, Taneyama Y, Terada K, Yanagimachi M, Ota S, Takahashi H, Inukai T, Toyama D, Keino D, Moriwaki K, Takagi M, Fujimura J, Sekinaka Y, Nakamura K, Sato Y et al
- Organizer
  ASH annual meeting 2016
- Place of Presentation
  サンディエゴ（アメリカ合衆国）
- Year and Date
  2016-12-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18932
[Presentation] MRP4遺伝子多型の小児急性リンパ性白血病に対する維持療法の臨床経過への影響2013
- Author(s)
  田中　庸一
- Organizer
  日本薬学会第133年会
- Place of Presentation
  横浜市
- Data Source
  KAKENHI-PROJECT-22790170
[Presentation] 小児急性リンパ性白血病の維持療法における副作用発現および投与量へのMRP4遺伝子多型の影響2013
- Author(s)
  田中庸一
- Organizer
  日本薬学会第133年会
- Place of Presentation
  横浜
- Year and Date
  2013-03-29
- Data Source
  KAKENHI-PROJECT-22790170
[Presentation] 小児急性リンパ性白血病の維持療法における副作用発現および投与量へのMRP4遺伝子多型の影響2012
- Author(s)
  田中　庸一
- Organizer
  第５４回日本小児血液・がん学会
- Place of Presentation
  横浜市
- Data Source
  KAKENHI-PROJECT-22790170
[Presentation] MRP4 遺伝子多型の小児急性リンパ性白血病に対する維持療法の臨床経過への影響2012
- Author(s)
  田中庸一
- Organizer
  第54回日本小児血液・がん学会学術集会
- Place of Presentation
  横浜
- Year and Date
  2012-12-02
- Data Source
  KAKENHI-PROJECT-22790170
[Presentation] 小児リンパ性白血病治療におけるMethylenetetrahydrofolate reductase遺伝子解析の有用性2012
- Author(s)
  田中庸一
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌
- Year and Date
  2012-03-31
- Data Source
  KAKENHI-PROJECT-22790170
[Presentation] 小児リンパ性白血病治療におけるMethylenetetrahydrofolate reductase遺伝子解析の有用性2012
- Author(s)
  田中庸一
- Organizer
  日本薬学会第132年会
- Place of Presentation
  北海道札幌市
- Year and Date
  2012-03-31
- Data Source
  KAKENHI-PROJECT-22790170
[Presentation] TPMT, ITPA, MTHFR polymorphisms influence on 6-mercaptopurine toxicities in maintenance chemotherapy for childhood acute lymphoblastic leukemia2011
- Author(s)
  Yoichi Tanaka, Atsushi Manabe, Tomoyuki Utano, Takako Komiyama
- Organizer
  5^<th> St.Jude-VIVA Forum in Pediatric Oncology 2011
- Place of Presentation
  シンガポール
- Year and Date
  2011-03-21
- Data Source
  KAKENHI-PROJECT-22790170
[Presentation] MTHFR polymorphisms influence on 6-mercaptopurine toxicities in maintenance chemotherapy for childhood acute lymphoblastic leukemia2011
- Author(s)
  Tanaka Y, TPMT, ITPA
- Organizer
  St. Jude-VIVA Forum in Pediatric Oncology
- Place of Presentation
  シンガポール
- Year and Date
  2011-03-21
- Data Source
  KAKENHI-PROJECT-22790170
[Presentation] 急性リンパ性白血病の維持療法における6-メルカプトプリン関連副作用発現へのTPMT,ITPA,MTHFR遺伝子型の影響2011
- Author(s)
  田中庸一
- Organizer
  第53回日本小児血液・がん学会学術集会
- Place of Presentation
  前橋
- Year and Date
  2011-11-27
- Data Source
  KAKENHI-PROJECT-22790170
[Presentation] 急性リンパ性白血病の維持療法における6-メルカプトプリン関連副作用発現へのTPMT,ITPA,MTHFR遺伝子型の影響2011
- Author(s)
  田中庸一
- Organizer
  第53回日本小児血液・がん学会学術集会
- Place of Presentation
  群馬県前橋市
- Year and Date
  2011-11-27
- Data Source
  KAKENHI-PROJECT-22790170

1. Manabe Atsushi (20292849)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
2. 浦山ケビン (60726850)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. 稲澤譲治

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

TANAKA YOICHI 田中 庸一

Yoichi Tanaka 田中 庸一

TANAKA Yoichi 田中 庸一

Research Projects

Research Products

Co-Researchers

NUDT15ハプロタイプによる酵素活性変動の要因と基質薬物の構造による影響の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Evaluation of anti-L-asparaginase antibody and difference of antibody production in each patientPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Personalized therapy for mercaptopurine by measuring metabolites in DNA in children with leukemiaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of gene polymorphisms related with adverse events in the treatment of childhood acute lymphoblastic leukemia

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Evaluation of genetic factors for drug sensitivity in childhood leukemia by genome wide association analysisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Pharmacogenetics of 6-mercaptopurine maintenance therapy for acutelymphoblastic leukemia in JapanesePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Regional evaluation of childhood acute lymphoblastic leukemia genetic susceptibility loci among Japanese2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Interaction between NUDT15 and ABCC4 variants enhances intolerability of 6-mercaptopurine in Japanese patients with childhood acute lymphoblastic leukemia2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The activity of the inosine triphosphate pyrophosphatase affects toxicity of 6-mercaptopurine during maintenance therapy for acute lymphoblastic leukemia in Japanese children2012

Author(s)

Journal Title

DOI

Data Source

[Presentation] 6-メルカプトプリン投与小児白血病患者におけるDNA中 deoxythioguanosineの定量と有害事象との関連性に関する検討2021

Author(s)

Organizer

Data Source

[Presentation] Efficacy of mercaptopurine sensitivity test after long-term exposure of leukemia cells2020

Author(s)

Organizer

Data Source

[Presentation] Association of NUDT15 gene polymorphism with cellular metabolism of thiopurine in BCP-ALL cell lines2019

Author(s)

Organizer

Data Source

[Presentation] NUDT15 genetic variation is the strongest predictive marker of tolerance to 6-mercaptopurine in Japanese childhood ALL patients: A genome-wide association study.2019

Author(s)

Organizer

Data Source

[Presentation] 患者の年齢と肥満度の6-メルカプトプリン投与量への影響2018

Author(s)

Organizer

Data Source

[Presentation] 1.小児ALLにおける高用量メトトレキサート療法時の薬物クリアランスへ影響を及ぼす因子の検討2018

Author(s)

Organizer

TANAKA YOICHI 田中庸一

Yoichi Tanaka 田中庸一

TANAKA Yoichi 田中庸一