Yoshizaki Ayumi 吉崎歩

… Alternative Names

YOSHIZAKI Ayumu 吉崎歩

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Researcher Number	40530415
External Links
Affiliation (Current)	2025: 東京大学, 医学部附属病院, 届出研究員
Affiliation (based on the past Project Information) *help	2025: 東京大学, 医学部附属病院, 特任准教授 2023: 東京大学, 医学部附属病院, 特任准教授 2022: 東京大学, 大学院医学系研究科, 特任准教授 2017 – 2022: 東京大学, 医学部附属病院, 講師 2014 – 2015: 東京大学, 医学部附属病院, 講師 … More 2011: 長崎大学, 医学部・歯学部付属病院, 講師 2010: 独立行政法人国立病院機構(長崎医療センター臨床研究センター), 長崎医療センター・皮膚科, 医師 2010: 長崎医療センター, 皮膚科, 医師 2009: 長崎大学, 医学部・歯学部附属病院, 医員 2009: Nagasaki University, 長崎大学病院, 医員 Less
Review Section/Research Field	Principal Investigator Basic Section 53050:Dermatology-related / Dermatology Except Principal Investigator Medium-sized Section 53:Organ-based internal medicine and related fields / Dermatology / Medium-sized Section 19:Fluid engineering, thermal engineering, and related fields / Basic Section 53050:Dermatology-related
Keywords	Principal Investigator 強皮症 / B細胞 / 全身性強皮症 / サイトカイン / 自己免疫疾患 / 自己免疫 / 動物モデル / 自己抗原反応性B細胞 / 超微量タンパク質分析 / 医工連携研究 … More / タンパク質微量分析 / マイクロフルイディクス / 超微量タンパク分析 / マイクロ・ナノデバイス / 免疫 / 膠原病 / 抗原特異性 / 制御性B細胞 / マウスモデル / Th細胞 / T細胞 / 細胞接着分子 … More Except Principal Investigator 強皮症 / 自己免疫 / 自己抗体 / サイトカイン / B細胞 / 自己免疫疾患 / プロテオーム / 全身性強皮症 / マウスモデル / 自己抗原 / 1分子 / 液滴 / ナノ流路 / ナノ流体工学 / IL-17 / IL-6 / 新規治療法開発 / MDA5 / MD5 / モデル動物 / 皮膚筋炎 / マイクロ・ナノデバイス / 皮膚免疫学 / 創傷治癒 / P-selectin / PSGL-1 / 細胞接着分子 Less

独自の網羅的自己抗原アレイを用いた全身性強皮症の病因解明Principal Investigator
- Principal Investigator
  
  吉崎歩
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53050:Dermatology-related
- Research Institution
  The University of Tokyo
B細胞をターゲットとした新たな超微量タンパク質分析法による強皮症の病態解析Principal Investigator
- Principal Investigator
  
  吉崎歩
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53050:Dermatology-related
- Research Institution
  The University of Tokyo
Establishment of a unitary pathogenesis hypothesis for systemic sclerosis based on B cells, IL-6 and IL-17
- Principal Investigator
  
  Sato Shinichi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53050:Dermatology-related
- Research Institution
  The University of Tokyo
Development of a method for single-molecule chemical processing utilizing ultra-small droplets in nanospace and application to cytokine analysis
- Principal Investigator
  
  嘉副裕
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Review Section
  
  Medium-sized Section 19:Fluid engineering, thermal engineering, and related fields
- Research Institution
  Keio University
Identification of a true extracellular autoantigen that cross-reacts with autoantibodies in systemic sclerosis.
- Principal Investigator
  
  Sato Shinichi
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 53:Organ-based internal medicine and related fields
- Research Institution
  The University of Tokyo
Functional analysis of autoantigen-reactive B cells in systemic sclerosis by ultra-sensitive protein analysis using microfluidics.Principal Investigator
- Principal Investigator
  
  Yoshizaki Ayumi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53050:Dermatology-related
- Research Institution
  The University of Tokyo
Innovative approach to anti-MDA5 antibody-positive dermatomyositis; Development of animal models and understanding of pathogenesis
- Principal Investigator
  
  Sato Shinichi
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 53:Organ-based internal medicine and related fields
- Research Institution
  The University of Tokyo
Functional analysis of antigen-specific B cells in systemic sclerosis using micro spacePrincipal Investigator
- Principal Investigator
  
  Yoshizaki Ayumi
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Dermatology
- Research Institution
  The University of Tokyo
Comprehensive analysis of autoantigen-reactive B cell in systemic sclerosis and identification of therapeutic targets
- Principal Investigator
  
  Sato Shinichi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Dermatology
- Research Institution
  The University of Tokyo
The role of regulatory B cells in systemic sclerosisPrincipal Investigator
- Principal Investigator
  
  Yoshizaki Ayumi
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Dermatology
- Research Institution
  The University of Tokyo
Involvement of selectins and their ligands in wound healing
- Principal Investigator
  
  SATO Shinichi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  The University of Tokyo
Cell adhesion molecules regulate fibrotic process in a bleomycin-induced scleroderma model.Principal Investigator
- Principal Investigator
  
  YOSHIZAKI Ayumi
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Dermatology
- Research Institution
  長崎医療センター
   Nagasaki University

[Book] Systemic Sclerosis: Basic and Translational Research2016
- Author(s)
  Yoshizaki A, Sato S
- Total Pages
  6
- Publisher
  Springer Publishing, Inc.
- Data Source
  KAKENHI-PROJECT-26893053
[Book] ガイドライン外来診療20152015
- Author(s)
  吉崎歩、佐藤伸一
- Total Pages
  3
- Publisher
  日経メディカル開発
- Data Source
  KAKENHI-PROJECT-26893053
[Book] Keynote R･A2014
- Author(s)
  吉崎歩
- Total Pages
  6
- Publisher
  先端医学社
- Data Source
  KAKENHI-PROJECT-26893053
[Journal Article] Dual blockade of interleukin-17A and interleukin-17F as a therapeutic strategy for liver fibrosis: Investigating the potential effect and mechanism of brodalumab2024
- Author(s)
  Matsuda Kazuki M.、Kotani Hirohito、Hisamoto Teruyoshi、Kuzumi Ai、Fukasawa Takemichi、Yoshizaki-Ogawa Asako、Sato Shinichi、Yoshizaki Ayumi
- Journal Title
  
  Cytokine
  
  Volume: 178 Pages: 156587-156587
- DOI
  10.1016/j.cyto.2024.156587
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K16258, KAKENHI-PROJECT-22K16259, KAKENHI-PROJECT-22K08425
[Journal Article] The role of B cells in systemic sclerosis2024
- Author(s)
  Fukasawa Takemichi、Yoshizaki‐Ogawa Asako、Sato Shinichi、Yoshizaki Ayumi
- Journal Title
  
  The Journal of Dermatology
  
  Volume: - Issue: 7 Pages: 904-913
- DOI
  10.1111/1346-8138.17134
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K16258, KAKENHI-PROJECT-22K08425, KAKENHI-PROJECT-21H02939
[Journal Article] Autoantibodies to nuclear valosin-containing protein-like protein: systemic sclerosis-specific antibodies revealed by in vitro human proteome2024
- Author(s)
  Matsuda Kazuki M, Fukasawa Takemichi et al.
- Journal Title
  
  Rheumatology
  
  Volume: - Issue: 10 Pages: 2865-2873
- DOI
  10.1093/rheumatology/keae063
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K16258, KAKENHI-PROJECT-22K16259, KAKENHI-PROJECT-22K08425, KAKENHI-PROJECT-21H02939
[Journal Article] Significance of anti-transcobalamin receptor antibodies in cutaneous arteritis revealed by proteome-wide autoantibody screening2023
- Author(s)
  Matsuda K, Kotani H, Yoshizaki A, et al.
- Journal Title
  
  Journal of Autoimmunity
  
  Volume: 135 Pages: 102995-102995
- DOI
  10.1016/j.jaut.2023.102995
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K08425, KAKENHI-PROJECT-22K16259, KAKENHI-PROJECT-21H02939, KAKENHI-PROJECT-21K19472, KAKENHI-PROJECT-22K16258
[Journal Article] Rapid improvement of systemic sclerosis-associated intestinal pseudo-obstruction with intravenous immunoglobulin administration.2023
- Author(s)
  Matsuda KM, Yoshizaki A, Kuzumi A, Toyama S, Awaji K, Miyake T, Sato S.
- Journal Title
  
  Rheumatology (Oxford)
  
  Volume: - Issue: 9 Pages: 3139-3145
- DOI
  10.1093/rheumatology/kead093
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K16259, KAKENHI-PROJECT-21H02939, KAKENHI-PROJECT-21K19472
[Journal Article] The Autoantibody Array Assay: A Novel Autoantibody Detection Method2023
- Author(s)
  Norimatsu Yuta、Matsuda Kazuki Mitsuru、Yamaguchi Kei、Ono Chihiro、Okumura Taishi、Kogo Emi、Kotani Hirohito、Hisamoto Teruyoshi、Kuzumi Ai、Fukasawa Takemichi、Yoshizaki-Ogawa Asako、Goshima Naoki、Sato Shinichi、Yoshizaki Ayumi
- Journal Title
  
  Diagnostics
  
  Volume: 13 Issue: 18 Pages: 2929-2929
- DOI
  10.3390/diagnostics13182929
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K16258, KAKENHI-PROJECT-22K08425, KAKENHI-PROJECT-21H02939
[Journal Article] Comprehensive autoantibody profiling in systemic autoimmunity by a highly-sensitive multiplex protein array2023
- Author(s)
  Kuzumi Ai、Norimatsu Yuta、Matsuda Kazuki M.、Ono Chihiro、Okumura Taishi、Kogo Emi、Goshima Naoki、Fukasawa Takemichi、Fushida Natsumi、Horii Motoki、Yamashita Takashi、Yoshizaki-Ogawa Asako、Yamaguchi Kei、Matsushita Takashi、Sato Shinichi、Yoshizaki Ayumi
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 14 Pages: 1255540-1255540
- DOI
  10.3389/fimmu.2023.1255540
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K16258, KAKENHI-PROJECT-22K16259, KAKENHI-PROJECT-22K08425, KAKENHI-PROJECT-21H02939
[Journal Article] Utility of nailfold capillary assessment for predicting pustulotic arthro-osteitis in palmoplantar pustulosis based on a prospective cohort study2023
- Author(s)
  Fukasawa Takemichi、Yamashita Takashi、Enomoto Atsushi、Toyama Satoshi、Yoshizaki-Ogawa Asako、Tateishi Shoko、Kanda Hiroko、Miyagawa Kiyoshi、Sato Shinichi、Yoshizaki Ayumi
- Journal Title
  
  Journal of the American Academy of Dermatology
  
  Volume: 89 Issue: 5 Pages: 984-991
- DOI
  10.1016/j.jaad.2023.07.1014
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K16258, KAKENHI-PROJECT-23K07055, KAKENHI-PROJECT-21H02939
[Journal Article] Long-term outcomes after rituximab treatment for patients with systemic sclerosis: follow-up of the DESIRES trial with a focus on serum immunoglobulin levels2023
- Author(s)
  Kuzumi A, Ebata S, Fukasawa T, Matsuda KM, Kotani H, Yoshizaki-Ogawa A, Sato S, Yoshizaki A
- Journal Title
  
  JAMA Dermatol
  
  Volume: - Issue: 4 Pages: 374-374
- DOI
  10.1001/jamadermatol.2022.6340
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K16259, KAKENHI-PROJECT-21H02939, KAKENHI-PROJECT-22K16258
[Journal Article] New Era in Systemic Sclerosis Treatment: Recently Approved Therapeutics2022
- Author(s)
  Ebata S, Yoshizaki-Ogawa A, Yoshizaki A.
- Journal Title
  
  Journal of Clinical Medicine
  
  Volume: 11 Issue: 15 Pages: 4631-4631
- DOI
  10.3390/jcm11154631
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K08425, KAKENHI-PROJECT-21H02939, KAKENHI-PROJECT-21K19472
[Journal Article] Autoantibody Landscape Revealed by Wet Protein Array: Sum of Autoantibody Levels Reflects Disease Status2022
- Author(s)
  Matsuda Kazuki M.、Yoshizaki Ayumi、Yamaguchi Kei、Fukuda Eriko、Okumura Taishi、Ogawa Koji、Ono Chihiro、Norimatsu Yuta、Kotani Hirohito、Hisamoto Teruyoshi、Kawanabe Ruriko、Kuzumi Ai、Fukasawa Takemichi、Ebata Satoshi、Miyagawa Takuya、Yoshizaki-Ogawa Asako、Goshima Naoki、Sato Shinichi
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 13 Pages: 893086-893086
- DOI
  10.3389/fimmu.2022.893086
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K16258, KAKENHI-PROJECT-22K16259, KAKENHI-PROJECT-21K19472
[Journal Article] Involvement of Molecular Mechanisms between T/B Cells and IL-23: From Palmoplantar Pustulosis to Autoimmune Diseases2022
- Author(s)
  Fukasawa T, Yoshizaki-Ogawa A, Yoshizaki A.
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 23 Issue: 15 Pages: 8261-8261
- DOI
  10.3390/ijms23158261
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K08425, KAKENHI-PROJECT-22K16258
[Journal Article] Serum C-X-C Chemokine Ligand 1 Levels in Patients with Systemic Sclerosis: Relationship of Clinical and Laboratory Observations to Anti-CD20 Monoclonal Antibody Administration2022
- Author(s)
  Kawanabe R, Yoshizaki A, et al
- Journal Title
  
  Life
  
  Volume: 12 Issue: 5 Pages: 646-646
- DOI
  10.3390/life12050646
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K08425, KAKENHI-PROJECT-22K16258, KAKENHI-PROJECT-22K16259
[Journal Article] Involvement of B cells in the development of systemic sclerosis2022
- Author(s)
  Yoshizaki A, et al.
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 13
- DOI
  10.3389/fimmu.2022.938785
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K08425, KAKENHI-PROJECT-22K16258, KAKENHI-PROJECT-21K19472
[Journal Article] Genital necrosis with cutaneous thrombosis after COVID-19 mRNA vaccination.2022
- Author(s)
  Kuzumi A, Yoshizaki A, Chiba K, Mitsuo S, Matsuda KM, Norimatsu Y, Nagai K, Omatsu J, Miyake T, Sato S.
- Journal Title
  
  J Eur Acad Dermatol Venereol.
  
  Volume: 36 Issue: 3
- DOI
  10.1111/jdv.17837
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K19472, KAKENHI-PROJECT-22K16259
[Journal Article] Single-cell-level protein analysis revealing the roles of autoantigen-reactive B lymphocytes in autoimmune disease and the murine model.2021
- Author(s)
  Fukasawa T, Yoshizaki A, Ebata S, Yoshizaki-Ogawa A, Asano Y, Enomoto A, Miyagawa K, Kazoe Y, Mawatari K, Kitamori T, Sato S.
- Journal Title
  
  Elife
  
  Volume: 10 Pages: 5-5
- DOI
  10.7554/elife.67209
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08787, KAKENHI-PROJECT-20K22925, KAKENHI-PROJECT-20K08100
[Journal Article] Interleukin-31 promotes fibrosis and T helper 2 polarization in systemic sclerosis2021
- Author(s)
  Kuzumi Ai、Yoshizaki Ayumi、Matsuda Kazuki M.、Kotani Hirohito、Norimatsu Yuta、Fukayama Maiko、Ebata Satoshi、Fukasawa Takemichi、Yoshizaki-Ogawa Asako、Asano Yoshihide、Morikawa Kyojiro、Kazoe Yutaka、Mawatari Kazuma、Kitamori Takehiko、Sato Shinichi
- Journal Title
  
  Nature Communications
  
  Volume: 12 Issue: 1 Pages: 5-5
- DOI
  10.1038/s41467-021-26099-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K22925, KAKENHI-PROJECT-21H02939
[Journal Article] Combined immunosuppressive therapy provides favorable prognosis and increased risk of cytomegalovirus reactivation in anti‐melanoma differentiation‐associated gene 5 antibody‐positive dermatomyositis2020
- Author(s)
  Matsuda Kazuki M.、Yoshizaki Ayumi、Kuzumi Ai、Fukasawa Takemichi、Ebata Satoshi、Yoshizaki‐Ogawa Asako、Sato Shinichi
- Journal Title
  
  The Journal of Dermatology
  
  Volume: - Issue: 5 Pages: 483-489
- DOI
  10.1111/1346-8138.15274
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H04239, KAKENHI-PROJECT-18K19532
[Journal Article] Skin thickness score as a surrogate marker of organ involvements in systemic sclerosis: a retrospective observational study.2019
- Author(s)
  Matsuda KM, Yoshizaki A, Kuzumi A, Fukasawa T, Ebata S, Miura S, Toyama T, Yoshizaki A, Sumida H, Asano Y, Oba K, Sato S.
- Journal Title
  
  Arthritis Res Ther
  
  Volume: 21 Issue: 1 Pages: 129-129
- DOI
  10.1186/s13075-019-1919-6
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08787, KAKENHI-PROJECT-17H04239, KAKENHI-PROJECT-19H03907
[Journal Article] Increased expression of aquaporin-1 in dermal fibroblasts and dermal microvascular endothelial cells possibly contributes to skin fibrosis and edema in patients with systemic sclerosis.2019
- Author(s)
  Yamashita T, Asano Y, Saigusa R, Taniguchi T, Nakamura K, Miura S, Toyama T, Takahashi T, Ichimura Y, Hirabayashi M, Yoshizaki A, Miyagaki T, Sugaya M, Sato S.
- Journal Title
  
  J Dermatol Sci
  
  Volume: 93 Issue: 1 Pages: 24-32
- DOI
  10.1016/j.jdermsci.2018.09.007
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10146, KAKENHI-PROJECT-18K19532
[Journal Article] A potential contribution of decreased galectin-7 expression in stratified epithelia to the development of cutaneous and esophageal manifestations in systemic sclerosis.2019
- Author(s)
  Saigusa R, Yamashita T, Miura S, Hirabayashi M, Nakamura K, Miyagawa T, Fukui Y, Yoshizaki A, Sato S, Asano Y.
- Journal Title
  
  Exp Dermatol.
  
  Volume: In press Issue: 5 Pages: 536-542
- DOI
  10.1111/exd.13900
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04239, KAKENHI-PROJECT-19H03680
[Journal Article] Cytokine analysis on a countable number of molecules from living single cells on nanofluidic devices.2019
- Author(s)
  Nakao T, Kazoe Y, Mori E, Morikawa K, Fukasawa T, Yoshizaki A, Kitamori T.
- Journal Title
  
  Analyst
  
  Volume: 144 Issue: 24 Pages: 7200-7208
- DOI
  10.1039/c9an01702j
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08787
[Journal Article] IL-10-Producing Regulatory B Cells Are Decreased in Patients with Atopic Dermatitis.2019
- Author(s)
  Yoshihara Y, Ishiuji Y, Yoshizaki A, Kurita M, Hayashi M, Ishiji T, Nakagawa H, Asahina A, Yanaba K.
- Journal Title
  
  J Invest Dermatol.
  
  Volume: 139 Issue: 2 Pages: 475-478
- DOI
  10.1016/j.jid.2018.08.016
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16324
[Journal Article] Rituximab therapy is more effective than cyclophosphamide therapy for Japanese patients with anti-topoisomerase I-positive systemic sclerosis-associated interstitial lung disease.2019
- Author(s)
  Ebata S, Yoshizaki A, Fukasawa T, Miura S, Takahashi T, Sumida H, Asano Y, Sato S.
- Journal Title
  
  J Dermatol
  
  Volume: 46 Issue: 11 Pages: 1006-1013
- DOI
  10.1111/1346-8138.15079
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08787, KAKENHI-PROJECT-19K08802, KAKENHI-PROJECT-17H04239, KAKENHI-PROJECT-18K19532
[Journal Article] Serum levels of human β-defensin 2: possible association with fibrosis and vasculopathy in patients with systemic sclerosis.2019
- Author(s)
  Kuzumi A, Yoshizaki A, Fukasawa T, Ebata S, Miura S, Yoshizaki A, Sumida H, Asano Y, Sato S.
- Journal Title
  
  J Eur Acad Dermatol Venereol.
  
  Volume: In press Issue: 7
- DOI
  10.1111/jdv.15546
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04239, KAKENHI-PROJECT-17K16324, KAKENHI-PROJECT-18K19532
[Journal Article] Prevention of calpain-dependent degradation of STK38 by MEKK2-mediated phosphorylation.2019
- Author(s)
  A. Enomoto, T. Fukasawa, H. Tsumoto, M. Karube, K. Nakagawa, A. Yoshizaki, S. Sato, Y. Miura, K. Miyagawa.
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 1038-1038
- DOI
  10.1038/s41598-019-52435-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10434, KAKENHI-PROJECT-18K19532
[Journal Article] Fli1 deficiency induces endothelial adipsin expression, contributing to the onset of pulmonary arterial hypertension in systemic sclerosis2019
- Author(s)
  Miyagawa Takuya、Taniguchi Takashi、Saigusa Ryosuke、Fukayama Maiko、Takahashi Takehiro、Yamashita Takashi、Hirabayashi Megumi、Miura Shunsuke、Nakamura Kouki、Yoshizaki Ayumi、Sato Shinichi、Asano Yoshihide
- Journal Title
  
  Rheumatology
  
  Volume: - Issue: 8 Pages: 2005-2015
- DOI
  10.1093/rheumatology/kez517
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H04239, KAKENHI-PROJECT-19H03680
[Journal Article] A potential contribution of trappin-2 to the development of vasculopathy in systemic sclerosis.2019
- Author(s)
  Miyagawa T, Asano Y, Saigusa R, Hirabayashi M, Yamashita T, Taniguchi T, Takahashi T, Nakamura K, Miura S, Yoshizaki A, Miyagaki T, Sato S.
- Journal Title
  
  J Eur Acad Dermatol Venereol.
  
  Volume: In press Issue: 4 Pages: 753-760
- DOI
  10.1111/jdv.15387
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04239, KAKENHI-PROJECT-19H03680, KAKENHI-PROJECT-18K19532
[Journal Article] Prediction of therapeutic response before and during i.v. cyclophosphamide pulse therapy for interstitial lung disease in systemic sclerosis: A longitudinal observational study2018
- Author(s)
  Sumida Hayakazu、Asano Yoshihide、Tamaki Zenshiro、Aozasa Naohiko、Taniguchi Takashi、Toyama Tetsuo、Takahashi Takehiro、Ichimura Yohei、Noda Shinji、Akamata Kaname、Saigusa Ryosuke、Miyazaki Miki、Kuwano Yoshihiro、Yanaba Koichi、Yoshizaki Ayumi、Sato Shinichi
- Journal Title
  
  The Journal of Dermatology
  
  Volume: 45 Issue: 12 Pages: 1425-1433
- DOI
  10.1111/1346-8138.14669
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05366, KAKENHI-PROJECT-17H04239
[Journal Article] Fli1-haploinsufficient dermal fibroblasts promote skin-localized transdifferentiation of Th2-like regulatory T cells2018
- Author(s)
  Saigusa Ryosuke、Asano Yoshihide、Taniguchi Takashi、Hirabayashi Megumi、Nakamura Kouki、Miura Shunsuke、Yamashita Takashi、Takahashi Takehiro、Ichimura Yohei、Toyama Tetsuo、Yoshizaki Ayumi、Trojanowska Maria、Sato Shinichi
- Journal Title
  
  Arthritis Research & Therapy
  
  Volume: 20 Issue: 1 Pages: 23-23
- DOI
  10.1186/s13075-018-1521-3
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04239
[Journal Article] Rapid alteration of serum interleukin-6 levels may predict the reactivity of i.v. cyclophosphamide pulse therapy in systemic sclerosis-associated interstitial lung disease.2018
- Author(s)
  Numajiri H, Yoshizaki A, Fukasawa T, Ebata S, Nakamura K, Yamashita T, Saigusa R, Miura S, Hirabayashi M, Yoshizaki A, Sumida H, Asano Y, Kazoe Y, Mawatari K, Kitamori T, Sato S.
- Journal Title
  
  J Dermatol.
  
  Volume: 45 Issue: 10 Pages: 1221-1224
- DOI
  10.1111/1346-8138.14580
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04239, KAKENHI-PROJECT-17K16324, KAKENHI-PROJECT-17K16325, KAKENHI-PROJECT-18K19532
[Journal Article] Systemic sclerosis complicated with localized scleroderma-like lesions induced by Koebner phenomenon.2018
- Author(s)
  Saigusa R, Asano Y, Yamashita T, Takahashi T, Nakamura K, Miura S, Ichimura Y, Toyama T, Taniguchi T, Sumida H, Tamaki Z, Miyazaki M, Yoshizaki A, Sato S.
- Journal Title
  
  J Dermatol Sci.
  
  Volume: 89 Issue: 3 Pages: 282-289
- DOI
  10.1016/j.jdermsci.2017.12.005
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15544, KAKENHI-PROJECT-17H04239, KAKENHI-PROJECT-16H05366
[Journal Article] An orally-active adiponectin receptor agonist mitigates cutaneous fibrosis, inflammation and microvascular pathology in a murine model of systemic sclerosis2018
- Author(s)
  Yamashita Takashi、Lakota Katja、Taniguchi Takashi、Yoshizaki Ayumi、Sato Shinichi、Hong Wen、Zhou Xingchun、Sodin-Semrl Snezn、Fang Feng、Asano Yoshihide、Varga John
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Issue: 1 Pages: 11843-11843
- DOI
  10.1038/s41598-018-29901-w
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05366, KAKENHI-PROJECT-17K16324, KAKENHI-PROJECT-18K19532
[Journal Article] Serum interleukin-34 levels in patients with systemic sclerosis: Clinical association with interstitial lung disease.2018
- Author(s)
  Kuzumi A, Yoshizaki A, Toyama S, Fukasawa T, Ebata S, Nakamura K, Yamashita T, Saigusa R, Miura S, Hirabayashi M, Yoshizaki A, Asano Y, Sato S.
- Journal Title
  
  J Dermatol.
  
  Volume: 28 Issue: 10 Pages: 314-319
- DOI
  10.1111/1346-8138.14538
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16324
[Journal Article] Fli1 Deficiency Induces CXCL6 Expression in Dermal Fibroblasts and Endothelial Cells, Contributing to the Development of Fibrosis and Vasculopathy in Systemic Sclerosis.2017
- Author(s)
  Taniguchi T, Asano Y, Nakamura K, Yamashita T, Saigusa R, Ichimura Y, Takahashi T, Toyama T, Yoshizaki A, Sato S.
- Journal Title
  
  J Rheumatol.
  
  Volume: 44 Issue: 8 Pages: 1198-1205
- DOI
  10.3899/jrheum.161092
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16323, KAKENHI-PROJECT-17K16324, KAKENHI-PROJECT-16H05366, KAKENHI-PROJECT-17H04239
[Journal Article] Possible pro-inflammatory role of heparin-binding epidermal growth factor-like growth factor in the active phase of systemic sclerosis2017
- Author(s)
  Hirabayashi Megumi、Asano Yoshihide、Yamashita Takashi、Miura Shunsuke、Nakamura Kouki、Taniguchi Takashi、Saigusa Ryosuke、Takahashi Takehiro、Ichimura Yohei、Miyagawa Takuya、Yoshizaki Ayumi、Miyagaki Tomomitsu、Sugaya Makoto、Sato Shinichi
- Journal Title
  
  The Journal of Dermatology
  
  Volume: 45 Issue: 2 Pages: 182-188
- DOI
  10.1111/1346-8138.14088
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04239, KAKENHI-PROJECT-16H05366
[Journal Article] Epithelial Fli1 deficiency drives systemic autoimmunity and fibrosis: Possible roles in scleroderma.2017
- Author(s)
  Takehiro Takahashi, Yoshihide Asano, Koji Sugawara, Kouki Nakamura, Takashi Yamashita, Ryosuke Saigusa, Yohei Ichimura, Tetsuo Toyama, Takashi Taniguchi, Kaname Akamata, Shinji Noda, Ayumi Yoshizaki, Daisuke Tsuruta, Maria Trojanowska, and Shinichi Sato
- Journal Title
  
  Journal of Experimental Medicine
  
  Volume: 214 Issue: 4 Pages: 1129-1151
- DOI
  10.1084/jem.20160247
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H06165, KAKENHI-PROJECT-16K15544, KAKENHI-PROJECT-17K16324, KAKENHI-PROJECT-16H05366, KAKENHI-PROJECT-16H06754
[Journal Article] Contribution of Soluble Forms of Programmed Death 1 and Programmed Death Ligand 2 to Disease Severity and Progression in Systemic Sclerosis2017
- Author(s)
  Fukasawa Takemichi、Yoshizaki Ayumi、Ebata Satoshi、Nakamura Kouki、Saigusa Ryosuke、Miura Syunsuke、Yamashita Takashi、Hirabayashi Megumi、Ichimura Yohei、Taniguchi Takashi、Asano Yoshihide、Shimizu Hisashi、Kazoe Yutaka、Mawatari Kazuma、Kitamori Takehiko、Sato Shinichi
- Journal Title
  
  Arthritis & Rheumatology
  
  Volume: 69 Issue: 9 Pages: 1879-1890
- DOI
  10.1002/art.40164
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16324, KAKENHI-PROJECT-17H04239
[Journal Article] A potential contribution of psoriasin to vascular and epithelial abnormalities and inflammation in systemic sclerosis2017
- Author(s)
  Takahashi T.、Asano Y.、Yamashita T.、Nakamura K.、Saigusa R.、Miura S.、Ichimura Y.、Toyama T.、Hirabayashi M.、Taniguchi T.、Yoshizaki A.、Sato S.
- Journal Title
  
  Journal of the European Academy of Dermatology and Venereology
  
  Volume: 32 Issue: 2 Pages: 291-297
- DOI
  10.1111/jdv.14459
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16324, KAKENHI-PROJECT-16H05366, KAKENHI-PROJECT-16K15544
[Journal Article] Multifaceted contribution of the TLR4-activated IRF5 transcription factor in systemic sclerosis.2016
- Author(s)
  Saigusa R, Asano Y, Taniguchi T, Yamashita T, Ichimura Y, Takahashi T, Toyama T, Yoshizaki A, Sugawara K, Tsuruta D, Taniguchi T, Sato S.
- Journal Title
  
  Proc Natl Acad Sci USA.
  
  Volume: 112 Issue: 49 Pages: 15136-41
- DOI
  10.1073/pnas.1520997112
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26893053, KAKENHI-PROJECT-15H05787
[Journal Article] IL-21 induces regulatory B cell differentiation and immunosuppressive effect through cognate interaction with T cells2015
- Author(s)
  吉崎歩、Tedder F Thomas
- Journal Title
  
  Japanese Journal of Clinical Immunology
  
  Volume: 38 Issue: 1 Pages: 57-64
- DOI
  10.2177/jsci.38.57
- NAID
  130004875952
- ISSN
  0911-4300, 1349-7413
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26893053
[Journal Article] Cutaneous apocrine carcinoma of the scrotum: A case with widespread subcutaneous induration.2015
- Author(s)
  Miyagawa T, Kadono T, Taniguchi T, Nakamura K, Saigusa R, Yoshizaki A, Miyagaki T, Yamada D, Masui Y, Sato S.
- Journal Title
  
  J Dermatol.
  
  Volume: 42 Issue: 8 Pages: 815-7
- DOI
  10.1111/1346-8138.12914
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26893053
[Journal Article] Abnormal B lymphocyte activation and function in systemic sclerosis.2015
- Author(s)
  Yoshizaki A, Sato S.
- Journal Title
  
  Ann Dermatol
  
  Volume: 27 Issue: 1 Pages: 1-9
- DOI
  10.5021/ad.2015.27.1.1
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26893053
[Journal Article] Nucleosome in patients with systemic sclerosis: possible association with immunological abnormalities via abnormal activation of T and B cells2015
- Author(s)
  Yoshizaki A, Taniguchi T, Saigusa R, Fukasawa T, Ebata S, Numajiri H, Nakamura K, Yamashita T, Takahashi T, Toyama T, Asano Y, Tedder TF, Sato S.
- Journal Title
  
  Ann Rheum Dis.
  
  Volume: N/A Issue: 10 Pages: 1858-1865
- DOI
  10.1136/annrheumdis-2015-207405
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26893053
[Journal Article] Age-Dependent Defects of Regulatory B Cells in Wiskott-Aldrich Syndrome Gene Knockout Mice.2015
- Author(s)
  Yokoyama T, Yoshizaki A, Simon KL, Kirby MR, Anderson SM, Candotti F.
- Journal Title
  
  PLoS One.
  
  Volume: 10 Issue: 10 Pages: e0139729-e0139729
- DOI
  10.1371/journal.pone.0139729
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26893053
[Journal Article] Paraneoplastic pemphigus occurring after bendamustine and rituximab therapy for relapsed follicular lymphoma.2015
- Author(s)
  Higo T, Miyagaki T, Nakamura F, Shinohara A, Asano H, Abe H, Senda N, Yoshizaki A, Fukayama M, Kurokawa M.
- Journal Title
  
  Ann Hematol
  
  Volume: 94 Issue: 4 Pages: 683-5
- DOI
  10.1007/s00277-014-2202-1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26893053
[Journal Article] Treatment with rapamycin prevents fibrosis in tight-skin and bleomycin-induced mouse models of systemic sclerosis.2010
- Author(s)
  Yoshizaki A, Yanaba K, Yoshizaki As, Iwata Y, Komura K, Ogawa F, Takenaka M, Shimizu K, Asano Y, Hasegawa M, Fujimoto M, Sato S.
- Journal Title
  
  Arthritis Rheum. 62(8)
  
  Pages: 2476-2487
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791082
[Journal Article] Cell adhesion molecules regulate fibrotic process via Th1/Th2/Th17 cell balance in a bleomycin-induced scleroderma model.2010
- Author(s)
  Ayumi Yoshizaki
- Journal Title
  
  J Immunol
  
  Volume: 185(4) Pages: 2502-2515
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791082
[Journal Article] The Differential Role of L-Selectin and ICAM-1 in Th1-Type and Th2-Type Contact Hypersensitivity2010
- Author(s)
  Ogawa A, Yoshizaki A, et al
- Journal Title
  
  J Invest Dermatol (Ahead of print)(Ahead of print)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791082
[Journal Article] Cell adhesion molecules regulate fibrotic process via Th1/Th2/Th17 cell balance in a bleomycin-induced scleroderma model.2010
- Author(s)
  Yoshizaki A, Yanaba K, Iwata Y, Komura K, Ogawa A, Akiyama Y, Muroi E, Hara T, Ogawa F, Takenaka M, Shimizu K, Hasegawa M, Fujimoto M, T fF Tedder, Sato S.
- Journal Title
  
  J Immunol. 185(4)
  
  Pages: 2502-2515
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791082
[Journal Article] Treatment with rapamycin prevents fibrosis in tight-skin and bleomycin-induced mouse models of systemic sclerosis.2010
- Author(s)
  Ayumi Yoshizaki
- Journal Title
  
  Arthritis Rheum
  
  Volume: 62(8) Pages: 2476-2487
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791082
[Journal Article] Serum CXCL16 concentrations correlate with the extent of skin sclerosis in patients with systemic sclerosis.2009
- Author(s)
  Yanaba K, Yoshizaki A, et al
- Journal Title
  
  J Rheumatol 36(9)
  
  Pages: 1917-1923
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791082
[Journal Article] Olopatadine hydrochloride inhibits scratching behavior induced by a proteinase-activated receptor 2 agonist in mice.2009
- Author(s)
  Yoshizaki A, Sato S.
- Journal Title
  
  J Dermatol Sci. 56(2)
  
  Pages: 136-139
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791082
[Journal Article] Expression patterns of angiopoietin-1, -2, and tie-2 receptor in ulcerative colitis support involvement of the angiopoietin/tie pathway in the progression of ulcerative colitis.2009
- Author(s)
  Yoshizaki A, Nakayama T, Naito S, Sekine I.
- Journal Title
  
  Dig Dis Sci. 54(10)
  
  Pages: 2094-2099
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791082
[Journal Article] Clinical significance of serum HMGB-1 and sRAGE levels in systemic sclerosis : association with disease severity.2009
- Author(s)
  Yoshizaki A, Komura K, Iwata Y, Ogawa F, Hara T, Muroi E, Takenaka M, Shimizu K, Hasegawa M, Fujimoto M, Sato S.
- Journal Title
  
  J Clin Immunol. 29(2)
  
  Pages: 180-189
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791082
[Presentation] Long-term efficacy of rituximab in patients with systemic sclerosis: follow-up of the DESIRES trial with a focus on immunoglobulin levels2024
- Author(s)
  Kuzumi A, Ebata S, Fukasawa T, Sato S, Yoshizaki A
- Organizer
  5th International Conference on Cutaneous Lupus Erythematosus 2023 (ICCLE 2023), ISID2023 Tokyo Satellite Meeting
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02939
[Presentation] The role of B cells in systemic sclerosis2024
- Author(s)
  Yuta Norimatsu, Takemichi Fukasawa, Yoshinori Kabeya, Fukasawa T, Yoshizaki A, Yoshizaki-Ogawa A, Sato S Toyama, Kazuki M Matsuda, Maiko Fukayama, Ai Kuzumi, Satoshi Ebata, Asako Yoshizaki-Ogawa, Haruka Ichimura, Sho Yonezawa, Hiroki Nakano, Makoto Sugaya, Shinichi Sato, and Ayumi Yoshizaki
- Organizer
  5th International Conference on Cutaneous Lupus Erythematosus 2023 (ICCLE 2023), ISID2023 Tokyo Satellite Meeting
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02939
[Presentation] 全身性強皮症における抗Ki抗体と筋症状の関連2024
- Author(s)
  松田和樹、小谷紘史、乗松雄大、遠山聡、佐藤伸一、吉崎歩
- Organizer
  第122回日本皮膚科学会総会
- Data Source
  KAKENHI-PROJECT-21H02939
[Presentation] In vitroヒトプロテオームと生物情報科学の融合による自己抗体オミクス解析2024
- Author(s)
  松田和樹、岩藤和広、小谷紘史、山口圭、奥村大志、小野千紘、内野莉加子、村上有美、松中浩、蔵野信、矢冨裕、岡本耕、森屋恭爾、河野正憲、岡本僚久、庄田宏文、藤尾圭志、五島直樹、吉崎歩、佐藤伸一
- Organizer
  第51回日本臨床免疫学会総会
- Data Source
  KAKENHI-PROJECT-21H02939
[Presentation] 全身性強皮症に対するリツキシマブの長期投与における有効性と血清免疫グロブリンの臨床的意義2024
- Author(s)
  久住藍、江畑慧、深澤毅倫、佐藤伸一、吉崎歩
- Organizer
  第122回日本皮膚科学会総会
- Data Source
  KAKENHI-PROJECT-21H02939
[Presentation] The role of B cells in systemic sclerosis.2023
- Author(s)
  Fukasawa T, Yoshizaki A, Yoshizaki-Ogawa A, Sato S.
- Organizer
  5th International Conference on Cutaneous Lupus Erythematosus 2023.
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K08425
[Presentation] 全身性強皮症における自己抗体の意義2023
- Author(s)
  吉崎　歩
- Organizer
  第122回日本皮膚科学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-22K08425
[Presentation] Novel comprehensive detection method for autoantibodies and its clinical application.2023
- Author(s)
  Yoshizaki A.
- Organizer
  5th International Conference on Cutaneous Lupus Erythematosus 2023.
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K08425
[Presentation] 全身性強皮症の病態2023
- Author(s)
  吉崎　歩
- Organizer
  第122回日本皮膚科学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-22K08425
[Presentation] Long-term efficacy of rituximab in patients with systemic sclerosis: follow-up of the DESIRES trial with a focus on immunoglobulin levels.2023
- Author(s)
  Kuzumi A, Ebata S, Fukasawa T, Sato S, Yoshizaki A.
- Organizer
  5th International Conference on Cutaneous Lupus Erythematosus 2023.
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K08425
[Presentation] 強皮症治療の進歩2019
- Author(s)
  吉崎　歩
- Organizer
  第47回日本臨床免疫学会総会
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08787
[Presentation] Tissue microenvironment maintains tissue-resident B cells during B cell depletion therapy in systemic sclerosis2019
- Author(s)
  Ayumi Yoshizaki, Ai Kuzumi, Takemichi Fukasawa, Satoshi Ebata, Shinichi Sato
- Organizer
  14th Annual Meeting of the Taiwanese Society for Investigative Dermatology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04239
[Presentation] Microenvironment in systemic sclerosis provides a protective niche for tissue-resident B cells during B cell depletion therapy with anti-CD20 antibody2019
- Author(s)
  Ai Kuzumi, Ayumi Yoshizaki, Takemichi Fukasawa, Satoshi Ebata, Yoshihide Asano, Shinichi Sato
- Organizer
  2019 ACR (83th)/ARHP (53th) Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08787
[Presentation] Responses to therapy are determined by effector B cells in systemic sclerosis-associated interstitial lung disease2019
- Author(s)
  Satoshi Ebata, Ayumi Yoshizaki, Takemichi Fukasawa, Kazuma Mawatari, Takehiko Kitamori, Shinichi Sato
- Organizer
  14th Annual Meeting of the Taiwanese Society for Investigative Dermatology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19532
[Presentation] Microenvironment in systemic sclerosis provides a protective niche for tissue-resident B cells during B cell depletion therapy with anti-CD20 antibody2019
- Author(s)
  Ai Kuzumi, Ayumi Yoshizaki, Takemichi Fukasawa, Satoshi Ebata, Yoshihide Asano, Shinichi Sato
- Organizer
  2019 ACR (83th)/ARHP (53th) Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04239
[Presentation] Microenvironment in systemic sclerosis provides a protective niche for tissue-resident B cells during B cell depletion therapy with anti-CD20 antibody2019
- Author(s)
  Ai Kuzumi, Ayumi Yoshizaki, Takemichi Fukasawa, Satoshi Ebata, Yoshihide Asano, Shinichi Sato
- Organizer
  2019 ACR (83th)/ARHP (53th) Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19532
[Presentation] Tissue microenvironment maintains tissue-resident B cells during B cell depletion therapy in systemic sclerosis2019
- Author(s)
  Ayumi Yoshizaki, Ai Kuzumi, Takemichi Fukasawa, Satoshi Ebata, Shinichi Sato
- Organizer
  14th Annual Meeting of the Taiwanese Society for Investigative Dermatology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19532
[Presentation] 全身性強皮症の組織微小環境は、抗CD20交代によるB細胞除去療法において、組織中B細胞のprotective nicheとしてはたらく2019
- Author(s)
  久住藍、吉崎歩、深澤毅倫、江畑慧、佐藤伸一
- Organizer
  第47回日本臨床免疫学会総会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04239
[Presentation] Tissue microenvironment provides a protective niche for tissue-resident B cells during B cell depletion therapy with anti-CD20 antibody in systemic sclerosis2019
- Author(s)
  Kuzumi A, Yoshizaki A, Fukasawa T, Ebata S, Asano Y, Sato S
- Organizer
  16th International Workshop on SCLERODERMA RESEARCH
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04239
[Presentation] Functional elucidation of autoantige-reactive B cells by single cell protein analysis2019
- Author(s)
  Ayumi Yoshizaki
- Organizer
  The 44th Annual Meeting of the Japanese Society for Investigative Dermatology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08787
[Presentation] Responses to therapy are determined by effector B cells in systemic sclerosis-associated interstitial lung disease2019
- Author(s)
  Satoshi Ebata, Ayumi Yoshizaki, Takemichi Fukasawa, Kazuma Mawatari, Takehiko Kitamori, Shinichi Sato
- Organizer
  14th Annual Meeting of the Taiwanese Society for Investigative Dermatology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04239
[Presentation] Serum levels of soluble PD-1 and PD-L2 associate with abnormal immune activation and disease severity in patients with systemic sclerosis.2018
- Author(s)
  Yoshizaki A, Fukasawa T, Ebata S, Yoshizaki A, Kazoe Y, Mawatari K, Kitamori T, Sato S.
- Organizer
  The 5th Eastern Asia Dermatology Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04239
[Presentation] Direct Interaction between Autoreactive B Cells and Endothelial Colony Forming Cells Induces Cytokine Production from B cells through B Cell Receptor and IL-6-JAK2-STAT3 Signaling Pathway, Suppressing Proliferation of Endothelial Colony Forming Cells in Systemic Scleosis2018
- Author(s)
  Fukasawa T, Yoshizaki A, Ebata S, Nakamura K, Asano Y, Kazoe Y, Mawatari K, Kitamori T, Sato S
- Organizer
  2018 ACR (82th)/ARHP (53th) Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16324
[Presentation] Direct Interaction between Autoreactive B Cells and Endothelial Colony Forming Cells Induces Cytokine Production from B cells through B Cell Receptor and IL-6-JAK2-STAT3 Signaling Pathway, Suppressing Proliferation of Endothelial Colony Forming Cells in Systemic Scleosis.2018
- Author(s)
  Fukasawa T, Yoshizaki A, Ebata S, Nakamura K, Asano Y, Kazoe Y, Mawatari K, Kitamori T, Sato S
- Organizer
  2018 ACR (82th)/ARHP (53th) Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04239
[Presentation] Elevated Serum Interleukin-34 Levels Are Correlated with Interstitial Lung isease in Systemic Sclerosis2018
- Author(s)
  Suga H, Kuzumi A, Asano Y, Yoshizaki A, Sato S
- Organizer
  2018 ACR (82th)/ARHP (53th) Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19532
[Presentation] Heterozygote deficiency of the keratinocyte proline-rich protein enhances the skin barrier by increasing lysophosphatidic acid receptor expression.2018
- Author(s)
  Matsumoto A, Yoshizaki A, Nakanishi H, Ishikawa S, Fukayama M, Sato S
- Organizer
  The 5th Eastern Asia Dermatology Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04239
[Presentation] The cytokine profile revealed with the high sensitive microfluidic-ELISA system associates with the efficacy of antibody drugs in psoriasis2018
- Author(s)
  Fukasawa T, Yoshizaki A, Ebata S, Asano Y, Kazoe Y, Mawatari K, Kitamori T, Sato S
- Organizer
  11th Asian Dermatological Congress held in conjunction with the 18th Dubai World Dermatology & Laser Conference and Exhibition-Dubai Derma
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04239
[Presentation] 医工連携研究による単一細胞サイトカイン解析が紐解く、自己抗原特異的B細胞の全身性強皮症における役割2018
- Author(s)
  吉崎　歩
- Organizer
  第46回日本臨床免疫学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-17K16324
[Presentation] Rapid alteration of serum interleukin-6 levels may predict the reactivity of i.v. cyclophosphamide pulse therapy in systemic sclerosis-associated interstitial lung disease.2018
- Author(s)
  Numajiri H, Yoshizaki A, Fukasawa T, Ebata S, Nakamura K, Yamashita T, Saigusa R, Miura S, Hirabayashi M, Yoshizaki A, Sumida H, Asano Y, Kazoe Y, Mawatari K, Kitamori T, Sato S.
- Organizer
  The 5th Eastern Asia Dermatology Congress (EADC2018)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19532
[Presentation] B cell depletion ameliorates tissue fibrosis through regulating macrophage differentiation in a bleomycin-induced systemic sclerosis model mouse.2018
- Author(s)
  Numajiri H, Yoshizaki A, Fukasawa T, Ebata S, Asano Y, Sato S
- Organizer
  2018 The 19th Annual European Congress of Rheumatology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04239
[Presentation] 全身性強皮症における血管障害に対するtopoisomerase I特異的B細胞の役割2018
- Author(s)
  深澤毅倫、吉崎歩、江畑慧、久住藍、平川麻衣子、吉崎麻子、浅野善英、嘉副裕、馬渡和真、北森武彦、佐藤伸一
- Organizer
  第46回日本臨床免疫学会総会
- Data Source
  KAKENHI-PROJECT-18K19532
[Presentation] Single cell analysis revealed that autoantigen-reactive B cells contribute to the development of systemic sclerosis2018
- Author(s)
  Ayumi Yoshizaki
- Organizer
  11th Asian Dermatological Congress held in conjunction with the 18th Dubai World Dermatology & Laser Conference and Exhibition-Dubai Derma
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16324
[Presentation] 全身性強皮症患者における血清IL-34値の検討2018
- Author(s)
  久住藍、吉崎歩、遠山聡、深澤毅倫、江畑慧、中村洸樹、三枝良輔、三浦俊介、吉崎麻子、浅野善英、佐藤伸一
- Organizer
  第46回日本臨床免疫学会総会
- Data Source
  KAKENHI-PROJECT-18K19532
[Presentation] Direct Interaction between Autoreactive B Cells and Endothelial Colony Forming Cells Induces Cytokine Production from B cells through B Cell Receptor and IL-6-JAK2-STAT3 Signaling Pathway, Suppressing Proliferation of Endothelial Colony Forming Cells in Systemic Scleosis2018
- Author(s)
  Fukasawa T, Yoshizaki A, Ebata S, Nakamura K, Asano Y, Kazoe Y, Mawatari K, Kitamori T, Sato S
- Organizer
  2018 ACR (82th)/ARHP (53th) Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19532
[Presentation] The cytokine profile revealed with the high sensitive microfluidic-ELISA system associates with the efficacy of antibody drugs in psoriasis2018
- Author(s)
  Fukasawa T, Yoshizaki A, Ebata S, Asano Y, Kazoe Y, Mawatari K, Kitamori T, Sato S
- Organizer
  11th Asian Dermatological Congress held in conjunction with the 18th Dubai World Dermatology & Laser Conference and Exhibition-Dubai Derma
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16324
[Presentation] Elevated Serum Interleukin-34 Levels Are Correlated with Interstitial Lung isease in Systemic Sclerosis.2018
- Author(s)
  Suga H, Kuzumi A, Asano Y, Yoshizaki A, Sato S
- Organizer
  2018 ACR (82th)/ARHP (53th) Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04239
[Presentation] Elevated Serum Interleukin-34 Levels Are Correlated with Interstitial Lung isease in Systemic Sclerosis2018
- Author(s)
  Suga H, Kuzumi A, Asano Y, Yoshizaki A, Sato S
- Organizer
  2018 ACR (82th)/ARHP (53th) Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16324
[Presentation] B10 cells suppress contact dermatitis in an antigen specific manner2017
- Author(s)
  M Kamata, KM Candando, E Kountikov, A Yoshizaki, T Miyagaki, JM Lykken, JC Poe, S Sato, T Tedder
- Organizer
  2017 SID (76th) Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04239
[Presentation] Single cell analysis revealed that the response to cyclophosphamide therapy is regulated by B cells in systemic sclerosis-associated interstitial lung disease2017
- Author(s)
  Satoshi Ebata, Ayumi Yoshizaki, Takemichi Fukasawa, Takasgi Yamashita, Shunsuke Miura, Ryosuke Saigusa, Megumi Hirabayashi, Asako Yoshizaki, Kaname Akamata, Yoshihide Asano, Yutaka Kazoe, Kazuma Mawatari, Takehiko Kitamori, Shinichi Sato
- Organizer
  2017 ACR (81th)/ARHP (52th) Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16324
[Presentation] Cytokine profile revealed by medical-engineering collaboration study associates with the efficacy of antibody drugs in psoriasis2017
- Author(s)
  Ayumi Yoshizaki
- Organizer
  The 42nd Annual Meeting of the Japanese Society for Investigative Dermatology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16324
[Presentation] Fli1-deficient B cells induce scleroderma-like vascular disorganization via activating pro-angiogenic gene program in dermal microvascular endothelial cells - A possible role in scleroderma vasculopathy2017
- Author(s)
  Ryosuke Saigusa, Yoshihide Asano, Ayumi Yoshizaki, Maria Trojanowska, Shinichi Sato
- Organizer
  2017 SID (76th) Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04239
[Presentation] Distinct B cell cytokine production is determined by B cell autoantigen affinity and is related to its pathogenic role in systemic sclerosis2017
- Author(s)
  Takemichi Fukasawa, Ayumi Yoshizaki, Satoshi Ebata, Kouki Nakamura, Ryosuke Saigusa, Takashi Yamashita, Yoshihide Asano, Yutaka Kazoe, Kazuma Mawatari, Takehiko Kitamori, Shinichi Sato
- Organizer
  The 42nd Annual Meeting of the Japanese Society for Investigative Dermatology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04239
[Presentation] The novel micro-fluidic system reveals the pathogenic roles of vascular endothelium-specific B cells in cutaneous arteritis2017
- Author(s)
  Ayumi Yoshizaki, Kouki Nakamura, Satoshi Ebata, Takemichi Fukasawa, Yoshihide Asano, Yutaka Kazoe, Kazuma Mawatari, Takehiko Kitamori, Shinichi Sato
- Organizer
  The 42nd Annual Meeting of the Japanese Society for Investigative Dermatology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04239
[Presentation] Medical-engineering collaboration brings novel strategies for revealing the pathogenesis of autoimmune diseases2017
- Author(s)
  Ayumi Yoshizaki
- Organizer
  The 42nd Annual Meeting of the Japanese Society for Investigative Dermatology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16324
[Presentation] Regulatory B cells regulate skin and lung fibrosis and immunological abnormalities in a topoisomerase I and complete Freund's adjuvant-induced scleroderma model via an antigen-specific manner2015
- Author(s)
  Ayumi Yoshizaki
- Organizer
  2015 ACR (79th)/ARHP (50th) Annual Meeting
- Place of Presentation
  San Francisco The Moscone Center
- Year and Date
  2015-11-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26893053
[Presentation] 血管炎の新規治療2015
- Author(s)
  吉崎　歩
- Organizer
  第114回日本皮膚科学会総会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2015-05-29
- Invited
- Data Source
  KAKENHI-PROJECT-26893053
[Presentation] Serum levels of soluble PD-1 and PD-L2 correlate with disease severity in systemic sclerosis2015
- Author(s)
  Ayumi Yoshizaki
- Organizer
  2015 SID (74th) Annual Meeting
- Place of Presentation
  Atlanta Hilton Atlanta Hotel
- Year and Date
  2015-05-06
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26893053
[Presentation] 統合単一B細胞解析～留学を終え帰国してから自分自身の独自の研究テーマ模索について～2015
- Author(s)
  吉崎　歩
- Organizer
  第43回日本臨床免疫学会総会
- Place of Presentation
  神戸国際会議場
- Year and Date
  2015-10-22
- Invited
- Data Source
  KAKENHI-PROJECT-26893053
[Presentation] 全身性強皮症に合併した難治性皮膚潰瘍に対するボセンタンの有効性～7例の自験例についての報告～2010
- Author(s)
  吉崎歩、簗場広一、小川麻子、小村一浩、岩田洋平、小川文秀、佐藤伸一
- Organizer
  厚生労働省「強皮症における病因解明と根治的治療法の開発」研究班2009年度班会議・第13回強皮症研究会議
- Place of Presentation
  豊島区・大正製薬(株)本社2号館
- Year and Date
  2010-01-16
- Data Source
  KAKENHI-PROJECT-21791082
[Presentation] 強皮症合併間質性肺炎に対するエンドキサンパルス療法後の維持療法としてミゾリビンを用いた5例2010
- Author(s)
  吉崎歩、宿輪哲生、吉崎麻子、小川文秀、清水和宏、佐藤伸一
- Organizer
  日本皮膚科学会長崎地方会第310回例会
- Place of Presentation
  長崎大学医学部第一講義室
- Year and Date
  2010-04-04
- Data Source
  KAKENHI-PROJECT-21791082
[Presentation] Tight-skin(TSK)マウスおよびブレオマイシン(BLM)誘発強皮症マウスモデルにおけるラパマイシンの効果に関する検討2010
- Author(s)
  吉崎歩、簗場広一、小川麻子、小村一浩、岩田洋平、小川文秀、浅野善英、長谷川稔、藤本学、佐藤伸一
- Organizer
  厚生労働省「強皮症における病因解明と根治的治療法の開発」研究班2009年度班会議・第13回強皮症研究会議
- Place of Presentation
  豊島区・大正製薬(株)本社2号館
- Year and Date
  2010-01-16
- Data Source
  KAKENHI-PROJECT-21791082
[Presentation] CD19 regulates skin and lung fibrosis via Toll-Like receptor signaling in a model of bleomycin-induced scleroderma2009
- Author(s)
  Yoshizaki A, Sato S
- Organizer
  日本研究皮膚科学学会第34回年次学術大会・総会
- Place of Presentation
  福岡市・JALリゾートシーホークホテル福岡
- Year and Date
  2009-12-05
- Data Source
  KAKENHI-PROJECT-21791082
[Presentation] 強皮症との鑑別が難渋した抗アミノアシルtRNA合成酵素(ARS)抗体症候群の一例2009
- Author(s)
  吉崎歩、小川文秀、穐山雄一郎、清水和宏、佐藤伸一、鳥山史
- Organizer
  日本皮膚科学会長崎地方会第308回例会
- Place of Presentation
  佐世保市立総合病院講堂
- Year and Date
  2009-07-19
- Data Source
  KAKENHI-PROJECT-21791082
[Presentation] ブレオマイシン(BLM)誘発強皮症マウスモデルにおける細胞接着分子の役割に関する検討2009
- Author(s)
  吉崎歩、簗場広一、小村一浩、岩田洋平、小川文秀、長谷川稔、藤本学、佐藤伸一
- Organizer
  厚生労働省「強皮症における病因解明と根治的治療法の開発」研究班2008年度班会議・第12回強皮症研究会議(SSc, Scleroderma Study Conference)
- Place of Presentation
  文京区・エーザイ(株)
- Year and Date
  2009-01-17
- Data Source
  KAKENHI-PROJECT-21791082
[Presentation] 強皮症(SSc)合併間質性肺炎(IP)に対するエンドキサンパルス療法後の維持療法としてミゾリビンを用いた2例2009
- Author(s)
  吉崎歩、簗場広一、小村一浩、岩田洋平、小川文秀、長谷川稔、藤本学、佐藤伸一
- Organizer
  厚生労働省「強皮症における病因解明と根治的治療法の開発」研究班2008年度班会議・第12回強皮症研究会議(SSc, Scleroderma Study Conference)
- Place of Presentation
  文京区・エーザイ(株)
- Year and Date
  2009-01-17
- Data Source
  KAKENHI-PROJECT-21791082
[Presentation] 強皮症(SSc)合併間質性肺炎(IP)に対するエンドキサンパルス療法後の維持療法としてミゾリビンを用いた2例2009
- Author(s)
  吉崎歩、小川麻子、簗場広一、小村一浩、小川文秀、佐藤伸一
- Organizer
  第73回日本皮膚科学会東部支部学術大会
- Place of Presentation
  甲府市・甲府富士屋ホテル
- Year and Date
  2009-09-26
- Data Source
  KAKENHI-PROJECT-21791082
[Presentation] 制御性B細胞の分化誘導因子と作用機序に関する検討.
- Author(s)
  吉崎歩、Tedder Thomas
- Organizer
  第42回日本臨床免疫学会総会
- Place of Presentation
  新宿区・京王プラザホテル
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-26893053
[Presentation] Nucleosome, a basic repeating unit of chromatin, in patients with systemic sclerosis: Possible association with immunological abnormalities via anormal activation of T and B cells.
- Author(s)
  Yoshizaki A, Asano Y, Taniguchi T, Saigusa R, Nakamura K, Yamashita T, Takahashi T, Toyama T, Ichimura Y, Tamaki Z, Miyazaki M, Sato S.
- Organizer
  ACR/ARHP Annual Meeting
- Place of Presentation
  Boston Convention & Exhibition Center
- Year and Date
  2014-11-14 – 2014-11-19
- Data Source
  KAKENHI-PROJECT-26893053
[Presentation] Loss of IRF5 ameliorates tissue fibrosis in a murine model of systemic sclerosis.
- Author(s)
  Saigusa R, Asano Y, Tanighchi T, Ichimura Y, Takahashi T, Toyama T, Yoshizaki A, Taniguchi T, Sato S.
- Organizer
  ACR/ARHP Annual Meeting
- Place of Presentation
  Boston Convention & Exhibition Center
- Year and Date
  2014-11-14 – 2014-11-19
- Data Source
  KAKENHI-PROJECT-26893053
[]

1. SATO Shinichi (20215792)

# of Collaborated Projects: 5 results

# of Collaborated Products: 37 results
2. OGAWA Fumihide (10333519)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 北森武彦 (60214821)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
4. 嘉副裕 (20600919)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. SHISHIDO NAOMI

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. ASANO Yoshihide

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
7. 谷口隆志

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 久住藍

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
9. 深澤毅倫

# of Collaborated Projects: 0 results

# of Collaborated Products: 8 results
10. 菅谷誠

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 高橋岳浩

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 榎本敦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Yoshizaki Ayumi 吉崎 歩

YOSHIZAKI Ayumu 吉崎 歩

Research Projects

Research Products

Co-Researchers

独自の網羅的自己抗原アレイを用いた全身性強皮症の病因解明Principal Investigator

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B細胞をターゲットとした新たな超微量タンパク質分析法による強皮症の病態解析Principal Investigator

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Establishment of a unitary pathogenesis hypothesis for systemic sclerosis based on B cells, IL-6 and IL-17

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Development of a method for single-molecule chemical processing utilizing ultra-small droplets in nanospace and application to cytokine analysis

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Identification of a true extracellular autoantigen that cross-reacts with autoantibodies in systemic sclerosis.

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Functional analysis of autoantigen-reactive B cells in systemic sclerosis by ultra-sensitive protein analysis using microfluidics.Principal Investigator

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Innovative approach to anti-MDA5 antibody-positive dermatomyositis; Development of animal models and understanding of pathogenesis

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Functional analysis of antigen-specific B cells in systemic sclerosis using micro spacePrincipal Investigator

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Comprehensive analysis of autoantigen-reactive B cell in systemic sclerosis and identification of therapeutic targets

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The role of regulatory B cells in systemic sclerosisPrincipal Investigator

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Involvement of selectins and their ligands in wound healing

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Cell adhesion molecules regulate fibrotic process in a bleomycin-induced scleroderma model.Principal Investigator

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[Book] Systemic Sclerosis: Basic and Translational Research2016

Author(s)

Total Pages

Yoshizaki Ayumi 吉崎歩

YOSHIZAKI Ayumu 吉崎歩