Yotsumoto Fusanori 四元房典

… Alternative Names

四元房典ヨツモトフサノリ

YOTSUMOTO Fusanori 四元房典

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Researcher Number	40533089
Other IDs
Affiliation (Current)	2025: 福岡大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2025: 福岡大学, 医学部, 教授 2019 – 2020: 福岡大学, 医学部, 准教授 2018: 福岡大学, 医学部, 講師 2016: 福岡大学, 医学部, 講師 2014: 福岡大学, 医学部, 講師 2010 – 2011: 福岡大学, 医学部, 講師
Review Section/Research Field	Principal Investigator Basic Section 56040:Obstetrics and gynecology-related / Laboratory medicine Except Principal Investigator Basic Section 56040:Obstetrics and gynecology-related / Obstetrics and gynecology
Keywords	Principal Investigator 腫瘍検査学 / 乳癌 / HB-EGF Except Principal Investigator microRNA / 卵巣癌 / micro RNA / DDS / ウルトラファインバブル / 核酸医薬 / 診断マイクロアレイ … More / マイクロRNA / microRNA array / miR-135a-3p / miRNA / BK-UM / HB-EGF / バイオマーカー Less

統合転写プロファイルとマルチモーダルAI分析を用いたEAOC予測診断システムの構築Principal Investigator
- Principal Investigator
  
  四元房典
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Fukuoka University
Development of nucleic acid drug for intractable ovarian cancer using drug delivery system(DDS) by ultra fine bubble
- Principal Investigator
  
  Miyamoto Shingo
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Fukuoka University
Searching gene to manufacture the companion diagnostic agent targeting the HB-EGF.
- Principal Investigator
  
  Miyamoto Shingo
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Fukuoka University
Application for genes involved in regulation of HB-EGF expression as diagnostic markers and target molecules for breast cancerPrincipal Investigator
- Principal Investigator
  
  YOTSUMOTO Fusanori
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Laboratory medicine
- Research Institution
  Fukuoka University

All 2018 2017 2015 2014 2011 2010 Other

All Journal Article Presentation

[Journal Article] BK-UM in patients with recurrent ovarian cancer or peritoneal cancer: a first-in-human phase-I study.2017
- Author(s)
  Miyamoto S, Yotsumoto F,他３０名、 Iwamoto R, Mekada E.
- Journal Title
  
  BMC Cancer.
  
  Volume: 17 Issue: 1 Pages: 89-97
- DOI
  10.1186/s12885-017-3071-5
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26250033, KAKENHI-PROJECT-26293362, KAKENHI-PROJECT-15K07046
[Journal Article] Pre-clinical study of BK-UM, a novel inhibitor of HB-EGF, for ovarian cancer therapy.2014
- Author(s)
  Nam SO, Yotsumoto F, Miyata K, Suzaki Y, Yagi H, Odawara T, Manabe S, Ishikawa T, Kuroki M, Mekada E, Miyamoto S
- Journal Title
  
  Anticancer Research
  
  Volume: 34 Pages: 4615-4620
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26293362
[Journal Article] Contribution of transcription factor, SP1, to the promotion of HB-EGF expression in defense mechanism against the treatment of irinotecan in ovarian clear cell carcinoma.2014
- Author(s)
  Miyata K, Yotsumoto F, Nam SO, Odawara T, Manabe S, Ishikawa T, Itamochi H, Kigawa J, Takada S, Asahara H, Kuroki M, Miyamoto S
- Journal Title
  
  Cancer Medicine
  
  Volume: 3 Issue: 5 Pages: 1159-1169
- DOI
  10.1002/cam4.301
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26293362, KAKENHI-PROJECT-26670731
[Journal Article] Proteolytic activation of heparin-binding EGF-like growth factor by membrane-type matrix metalloproteinase-1 in ovarian carcinoma cells2011
- Author(s)
  Koshikawa N, Mizushima H, Minegishi T, Eguchi F, Yotsumoto F, Nabeshima K, Miyamoto S, Mekada E, Seiki M
- Journal Title
  
  Cancer Science
  
  Volume: Vol.102 Pages: 111-116
- NAID
  10029288679
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790536
[Journal Article] A Novel Anti-Human HB-EGF Monoclonal Antibody with Multiple Anti-Tumor Mechanisms Against Ovarian Cancer Cells2011
- Author(s)
  Miyamoto S, Iwamoto R, Furuya A, Takahashi K, Sasaki Y, Ando H, Yotsumoto F, Yoneda T, Hamaoka M, Yagi H, Murakami T, Hori S, Shitara K, Mekada E
- Journal Title
  
  Clinical Cancer Research
  
  Volume: Vol.17 Pages: 6733-6741
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790536
[Journal Article] Antitumor effects of CRM197, a specific inhibitor of HB-EGF, in T-cell acute lymphoblastic leukemia2011
- Author(s)
  Kunami N, Yotsumoto F, Ishitsuka K, Fukami T, Odawara T, Manabe S, Ishikawa T, Tamura K, Kuroki M, Miyamoto S
- Journal Title
  
  Anticancer Research
  
  Volume: Vol.31 Pages: 2483-2488
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790536
[Journal Article] A possible clinical adaptation of CRM197 in combination with conventional chemotherapeutic agents for ovarian cancer2011
- Author(s)
  Tsujioka H, Fukami T, Yotsumoto F, Ueda T, Hikita S, Takahashi Y, Kondo H, Kuroki M, Miyamoto S
- Journal Title
  
  Anticancer Research
  
  Volume: Vol.31 Pages: 2461-2465
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790536
[Journal Article] Assessment of HB-EGF levels in peritoneal fluid and serum of ovarian cancer patients using ELISA2011
- Author(s)
  Hikita S, Yotsumoto F, Fukami T, Horiuchi S, Sanui A, Miyata K, Nam S, Tsujioka H, Ueda T, Shirota K, Yoshizato T, Maeda K, Ishikawa T, Okuno Y, Kuroki M, Mekada E, Miyamoto S
- Journal Title
  
  Anticancer Research
  
  Volume: 31 Pages: 2553-2559
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790536
[Journal Article] Assessment of HB-EGF levels in peritoneal fluid and serum of ovarian cancer patients using ELISA2011
- Author(s)
  Hikita S, Yotsumoto F, Fukami T, Horiuchi S, Sanui A, Miyata K, Nam SO, Tsujioka H, Ueda T, Shirota K, Yoshizato T, Maeda K, Ishikawa T, Okuno Y, Kuroki M, Mekada E, Miyamoto S
- Journal Title
  
  Anticancer Research
  
  Volume: Vol.31 Pages: 2553-2559
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790536
[Journal Article] HB-EGF orchestrates the complex signals involved in triple-negative and trastuzumab-resistant breast cancer2010
- Author(s)
  Yotsumoto F, Oki E, Tokunaga E, Maehara Y, Kuroki M, Miyamoto S
- Journal Title
  
  International Journal of Cancer
  
  Volume: Vol.127 Pages: 2707-2717
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790536
[Journal Article] Apoptosis as a possiblecandidate mechanism for removal of tamoxifen-related endometrial cells with KRAS mutations2010
- Author(s)
  Tsujioka H, Hachisuga T, Hikita S, Ueda T, Yotsumoto F, Shirota K, Yoshizato T, Kawarabayashi T, Kuroki M, Miyamoto S
- Journal Title
  
  Anticancer Research
  
  Volume: Vol.30 Pages: 3119-3123
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790536
[Journal Article] Emerging strategies for ErbB ligand-based targeted therapy for cancer2010
- Author(s)
  Tsujioka H, Yotsumoto F, Shirota K, Horiuchi S, Yoshizato T, Kuroki M, Miyamoto S
- Journal Title
  
  Anticancer Research
  
  Volume: Vol.30 Pages: 3107-3112
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790536
[Journal Article] Amphiregulin regulates the activation of ERK and Akt through epidermal growth factor receptor and HER3 signals involved in the progression of pancreatic cancer2010
- Author(s)
  Yotsumoto F, Fukami T, Yagi H, Funakoshi A, Yoshizato T, Kuroki M, Miyamoto S
- Journal Title
  
  Cancer Science
  
  Volume: Vol.101 Pages: 2351-2360
- NAID
  10027833378
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790536
[Journal Article] Amphiregulin regulates the activation of ERK and Akt through epidermal growth factor receptor and HER3 signals involved in the progression of pancreatic cancer.2010
- Author(s)
  Yotsumoto F, Fukami T, Yagi H, Funakoshi A, Yoshizato T, Kuroki M, Miyamoto S.
- Journal Title
  
  Cancer Science
  
  Volume: 101 Pages: 2351-2360
- NAID
  10027833378
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790536
[Journal Article] HB-EGF orchestrates the complex signals involved in triple-negative and trastuzumab-resistant breast cancer.2010
- Author(s)
  Yotsumoto F, Oki E, Tokunaga E, Maehara Y, Kuroki M, Miyamoto S.
- Journal Title
  
  International Journal of Cancer
  
  Volume: 127 Pages: 2707-2717
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790536
[Journal Article] HB-EGF inhibition in combination with various anticancer agents enhances its antitumor effects in gastric cancer2010
- Author(s)
  Sanui A, Yotsumoto F, Tsujioka H, Fukami T, Horiuchi S, Shirota K, Yoshizato T, Kawarabayashi T, Kuroki M, Miyamoto S
- Journal Title
  
  Anticancer Research
  
  Volume: Vol.30 Pages: 3143-3149
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790536
[Journal Article] HB-EGF inhibition in combination with various anticancer agents enhances its antitumor effects in gastric cancer.2010
- Author(s)
  Sanui A, Yotsumoto F, Tsujioka H, Fukami T, Horiuchi S, Shirota K, Yoshizato T, Kawarabayashi T, Kuroki M, Miyamoto S.
- Journal Title
  
  Anticancer Research
  
  Volume: 30 Pages: 3143-3149
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790536
[Journal Article] Apoptosis as a possible candidate mechanism for removal of tamoxifen-related endometrial cells with KRAS mutations.2010
- Author(s)
  Tsujioka H, Hachisuga T, Hikita S, Ueda T, Yotsumoto F, Shirota K, Yoshizato T, Kawarabayashi T, Kuroki M, Miyamoto S.
- Journal Title
  
  Anticancer Research
  
  Volume: 30 Pages: 3119-3123
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790536
[Journal Article] Emerging strategies for ErbB ligand-based targeted therapy for cancer.2010
- Author(s)
  Tsujioka H, Yotsumoto F, Shirota K, Horiuchi S, Yoshizato T, Kuroki M, Miyamoto S.
- Journal Title
  
  Anticancer Research
  
  Volume: 30 Pages: 3107-3112
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790536
[Presentation] 再発卵巣癌の予後予測バイオマーカーとしての血中HB-EGFの有用性2018
- Author(s)
  深川怜史、井槌大介、勝田隆博、南　星旭、四元房典、宮原大輔、城田京子、宮本新吾
- Organizer
  日本産科婦人科学会第70回学術講演会
- Data Source
  KAKENHI-PROJECT-18K09242
[Presentation] 卵巣癌予後予測因子としての microRNA の解析2015
- Author(s)
  深川怜史、宮田康平、四元房典、黒木政秀、安永晋一郎、宮本新吾
- Organizer
  日本癌学会
- Place of Presentation
  (名古屋)名古屋国際会議場
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-26293362
[Presentation] 卵巣癌における予後予測および薬剤感受性に関わるmicroRNA2015
- Author(s)
  四元房典、深川怜史、宮田康平、南　星旭、安永晋一郎、黒木政秀、宮本新吾
- Organizer
  第14回日本婦人科がん分子標的研究会学術集会
- Place of Presentation
  (松本) 美ケ原温泉ホテル翔峰
- Year and Date
  2015-07-18
- Data Source
  KAKENHI-PROJECT-26293362
[Presentation] 卵巣癌予後予測因子としてのmicroRNAの検索2015
- Author(s)
  深川怜史、宮田康平、南星旭、四元房典、宮本新吾
- Organizer
  第67回日本産婦人科学会学術集会
- Place of Presentation
  (横浜)パシフィコ横浜
- Year and Date
  2015-04-09
- Data Source
  KAKENHI-PROJECT-26293362
[Presentation] 癌治療標的分子HB-EGFの翻訳制御にかかわる分子の同定2014
- Author(s)
  宮田康平、四元房典、深川怜史、南星旭、黒木政秀、宮本新吾
- Organizer
  第18回バイオ治療法研究会学術集会
- Place of Presentation
  高松
- Year and Date
  2014-12-13
- Data Source
  KAKENHI-PROJECT-26293362
[Presentation] Antitumor effect of intravenous injection of an HB-EGF inhibitor, CRM197, in triple negative breast cancer
- Author(s)
  Satoshi Fukagawa, Sung Ouk Nam, Fusanori Yotsumoto, Kohei Miyata, Masahide Kuroki, Shingo Miyamoto
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-26293362
[Presentation] Regulation of HB-EGF expression via a translational regulator, RBM8A.
- Author(s)
  Miyata K, Yotsumoto F, Nam SO, Fukagawa S, Kuroki M, Miyamoto S
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-26293362

1. Miyamoto Shingo (40209945)

# of Collaborated Projects: 2 results

# of Collaborated Products: 9 results
2. 深川怜史 (20772453)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
3. 鍋島一樹 (40189189)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 八木裕史 (70623552)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. 立花克郎 (40271605)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 目加田英輔

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 岩本亮

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Yotsumoto Fusanori 四元 房典

四元 房典 ヨツモト フサノリ

YOTSUMOTO Fusanori 四元 房典

Research Projects

Research Products

Co-Researchers

統合転写プロファイルとマルチモーダルAI分析を用いたEAOC予測診断システムの構築Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of nucleic acid drug for intractable ovarian cancer using drug delivery system(DDS) by ultra fine bubble

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Searching gene to manufacture the companion diagnostic agent targeting the HB-EGF.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Application for genes involved in regulation of HB-EGF expression as diagnostic markers and target molecules for breast cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] BK-UM in patients with recurrent ovarian cancer or peritoneal cancer: a first-in-human phase-I study.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Pre-clinical study of BK-UM, a novel inhibitor of HB-EGF, for ovarian cancer therapy.2014

Author(s)

Journal Title

Data Source

[Journal Article] Contribution of transcription factor, SP1, to the promotion of HB-EGF expression in defense mechanism against the treatment of irinotecan in ovarian clear cell carcinoma.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Proteolytic activation of heparin-binding EGF-like growth factor by membrane-type matrix metalloproteinase-1 in ovarian carcinoma cells2011

Author(s)

Journal Title

NAID

Data Source

[Journal Article] A Novel Anti-Human HB-EGF Monoclonal Antibody with Multiple Anti-Tumor Mechanisms Against Ovarian Cancer Cells2011

Author(s)

Journal Title

Data Source

[Journal Article] Antitumor effects of CRM197, a specific inhibitor of HB-EGF, in T-cell acute lymphoblastic leukemia2011

Author(s)

Journal Title

Data Source

[Journal Article] A possible clinical adaptation of CRM197 in combination with conventional chemotherapeutic agents for ovarian cancer2011

Author(s)

Journal Title

Data Source

[Journal Article] Assessment of HB-EGF levels in peritoneal fluid and serum of ovarian cancer patients using ELISA2011

Author(s)

Journal Title

Data Source

[Journal Article] Assessment of HB-EGF levels in peritoneal fluid and serum of ovarian cancer patients using ELISA2011

Author(s)

Journal Title

Data Source

[Journal Article] HB-EGF orchestrates the complex signals involved in triple-negative and trastuzumab-resistant breast cancer2010

Author(s)

Journal Title

Data Source

[Journal Article] Apoptosis as a possiblecandidate mechanism for removal of tamoxifen-related endometrial cells with KRAS mutations2010

Author(s)

Journal Title

Data Source

[Journal Article] Emerging strategies for ErbB ligand-based targeted therapy for cancer2010

Author(s)

Journal Title

Yotsumoto Fusanori 四元房典

四元房典ヨツモトフサノリ

YOTSUMOTO Fusanori 四元房典