Sakamoto Naoyuki 坂元直行

Researcher Number	40547981
Other IDs	https://orcid.org/0000-0001-5215-3621
Affiliation (Current)	2025: 朝日大学, 歯学部, 教授
Affiliation (based on the past Project Information) *help	2020 – 2023: 朝日大学, 歯学部, 教授 2016 – 2019: 公益財団法人ルイ・パストゥール医学研究センター, その他部局等, 研究員(移行) 2015: 公益財団法人ルイ・パストゥール医学研究センター, がん免疫医科学, 研究員 2014: 公益財団法人ルイ・パストゥール医学研究センター, その他部局等, 研究員
Review Section/Research Field	Principal Investigator Basic Section 52010:General internal medicine-related / General internal medicine(including psychosomatic medicine) Except Principal Investigator General internal medicine(including psychosomatic medicine)
Keywords	Principal Investigator シンプトンマネジメント / 疾患特異的QOL / 内因性腫瘍抗原 / 免疫チェックポイント阻害剤 / 免疫放射線療法 / 臨床 / 癌 / 進行がん / QOL / 血清サイトカインレベル … More / 免疫機能パラメーター / がん関連症状 / サイトカインプロファイリング / QOL層別化ツール / 末梢血インターフェロンγ産生能 … More Except Principal Investigator 腸内フローラ / 腸内細菌叢 / がん悪液質 / 細胞移入療法 / がん免疫療法 / 免疫チェックポイント阻害剤 Less

The development of integrated symptom management intervention making full use of Immune-radiotherapy plus chemotherapy in patients with advanced cancerPrincipal Investigator
- Principal Investigator
  
  坂元直行
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Asahi University
Development of new therapeutic strategies for cancer cachexia targeting gut microbiota
- Principal Investigator
  
  Ishikawa Takeshi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General internal medicine(including psychosomatic medicine)
- Research Institution
  Kyoto Prefectural University of Medicine
The development of stratification tool to assess disease-specific health-related QOL in patients with advanced incurable cancerPrincipal Investigator
- Principal Investigator
  
  Sakamoto Naoyuki
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General internal medicine(including psychosomatic medicine)
- Research Institution
  Louis Pasteur Center for Medical Research
Development of novel immune cell therapy combined with immune checkpoint inhibitors
- Principal Investigator
  
  Ishikawa Takeshi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General internal medicine(including psychosomatic medicine)
- Research Institution
  Kyoto Prefectural University of Medicine

All 2024 2023 2021 2020 2019 2018 2017 2015 2014

All Journal Article Presentation

[Journal Article] Metformin inhibits TGF-β1-induced epithelial-mesenchymal transition and liver metastasis of pancreatic cancer cells2020
- Author(s)
  Yoshida J, Ishikawa T, Endo Y, Matsumura S, Ota T, Mizushima K, Hirai Y, Oka K, Okayama T, Sakamoto N, Inoue K, Kamada K, Uchiyama K, Takagi T, Naito Y, Itoh Y.
- Journal Title
  
  Oncology Reports
  
  Volume: 44 Issue: 1 Pages: 371-381
- DOI
  10.3892/or.2020.7595
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09314, KAKENHI-PROJECT-20K07787
[Journal Article] Skeletal muscle mass as a predictor of the response to neo-adjuvant chemotherapy in locally advanced esophageal cancer.2019
- Author(s)
  Ota T, Ishikawa T, Endo Y, Matsumura S, Yoshida J, Yasuda T, Okayama T, Inoue K, Dohi O, Yoshida N, Sakamoto N, Kamada K, Uchiyama K, Takagi T, Konishi H, Konishi H, Shiozaki A, Fujiwara H, Kishimoto M, Naito Y, Itoh Y.
- Journal Title
  
  Medical Oncology
  
  Volume: 36(2) Issue: 2
- DOI
  10.1007/s12032-018-1242-0
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09274
[Journal Article] Clinical significance of soluble forms of immune checkpoint molecules in advanced esophageal cancer2019
- Author(s)
  Yoshida J, Ishikawa T, Doi T, Ota T, Yasuda T, Okayama T, Sakamoto N, Inoue K, Dohi O, Yoshida N, Kamada K, Uchiyama K, Takagi T, Konishi H, Naito Y, Itoh Y.
- Journal Title
  
  Medical Oncology
  
  Volume: 36(7) Issue: 7 Pages: 60-60
- DOI
  10.1007/s12032-019-1285-x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09314
[Journal Article] Phase I clinical trial of adoptive transfer of expanded natural killer cells in combination with IgG1 antibody in patients with gastric or colorectal cancer.2018
- Author(s)
  Ishikawa T, Okayama T, Sakamoto N, Ideno M, Oka K, Enoki T, Mineno J, Yoshida N, Katada K, Kamada K, Uchiyama K, Handa O, Takagi T, Konishi H, Kokura S, Uno K, Naito Y, Itoh Y.
- Journal Title
  
  Int J Cancer
  
  Volume: 142 Issue: 12 Pages: 2599-2609
- DOI
  10.1002/ijc.31285
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K01482, KAKENHI-PROJECT-16K09274
[Journal Article] The JAK/STAT pathway is involved in the upregulation of PD-L1 expression in pancreatic cancer cell lines.2017
- Author(s)
  Doi T, Ishikawa T, Okayama T, Oka K, Mizushima K, Yasuda T, Sakamoto N, Katada K, Kamada K, Uchiyama K, Handa O, Takagi T, Naito Y, Itoh Y
- Journal Title
  
  Oncology report
  
  Volume: 37 Issue: 3 Pages: 1545-1554
- DOI
  10.3892/or.2017.5399
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460914
[Journal Article] Tumor inoculation site affects the development of cancer cachexia and muscle wasting.2015
- Author(s)
  Matsuyama T, Ishikawa T, Okayama T, Oka K, Adachi S, Mizushima K, Kimura R, Okajima M, Sakai H, Sakamoto N, Katada K, Kamada K, Uchiyama K, Handa O, Takagi T, Kokura S, Naito Y, Itoh Y.
- Journal Title
  
  Int J Cancer.
  
  Volume: Dec 1;137(11) Issue: 11 Pages: 2558-65
- DOI
  10.1002/ijc.29620
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460914, KAKENHI-PROJECT-25350612
[Journal Article] Phase I clinical trial of autologous NK cell therapy using novel expansion method in patients with advanced digestive cancer.2015
- Author(s)
  Sakamoto N, Ishikawa T, Kokura S, Okayama T, Oka K, Ideno M, Sakai F, Kato A, Tanabe M, Enoki T, Mineno J, Naito Y, Itoh Y, Yoshikawa T.
- Journal Title
  
  J Transl Med.
  
  Volume: Aug 25;13 Issue: 1 Pages: 277-277
- DOI
  10.1186/s12967-015-0632-8
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460914, KAKENHI-PROJECT-25350612
[Journal Article] Cytotoxic T lymphocyte-associated antigen 4 inhibition increases the antitumor activity of adoptive T-cell therapy when carried out with naïve rather than differentiated T cells.2015
- Author(s)
  Ishikawa T, Adachi S, Okayama T, Kokura S
- Journal Title
  
  Oncol Rep.
  
  Volume: 33(5) Issue: 5 Pages: 2545-2552
- DOI
  10.3892/or.2015.3815
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25350612, KAKENHI-PROJECT-26460914
[Presentation] 消化管がんにおけるミスマッチ修復蛋白IHC検査のリアルワールドデータ；免疫療法における個別化医療の実践を目指して2024
- Author(s)
  坂元直行、八木信明、田中秀典、杉江茂幸
- Organizer
  第20回日本消化管学会総会学術集会（GI Week 2024）パネルディスカッション
- Data Source
  KAKENHI-PROJECT-20K07796
[Presentation] 同時性、および異時性多発胃癌の内視鏡的治療と成績2023
- Author(s)
  杉野敏志、中畑由紀、坂元直行
- Organizer
  日本消化器内視鏡学会東海支部第66回例会　シンポジウム１
- Data Source
  KAKENHI-PROJECT-20K07796
[Presentation] ミスマッチ修復蛋白IHC検査のリアルワールドデータが可視化するがん免疫療法における適切な患者選択の重要性2023
- Author(s)
  坂元直行
- Organizer
  日本バイオセラピィ学会　第36回学術集会総会：JSBT会員要望演題第1位「免疫チェックポイント阻害剤のバイオマーカー探索」
- Data Source
  KAKENHI-PROJECT-20K07796
[Presentation] 消化器がんに対する免疫放射線療法の可能性2021
- Author(s)
  坂元　直行
- Organizer
  第25回日本がん分子標的治療学会学術集会（ワークショップ）
- Data Source
  KAKENHI-PROJECT-20K07796
[Presentation] 消化器がんに対する免疫放射線療法の可能性2021
- Author(s)
  坂元直行
- Organizer
  第25回日本がん分子標的治療学会学術集会（ワークショップ）
- Data Source
  KAKENHI-PROJECT-20K07796
[Presentation] 高齢者胃がん診療における治療選択と自己決定への影響因子に関する検討2020
- Author(s)
  中畑由紀、坂元直行、林完成、向井理英子、尾松達司、大洞昭博、小島孝雄、八木信明
- Organizer
  第28回日本消化器関連学会週間（2020 JDDW）
- Data Source
  KAKENHI-PROJECT-20K07796
[Presentation] 進行胃癌に対する放射線療法と免疫チェックポイント阻害による集学的治療の可能性2020
- Author(s)
  坂元直行、林完成、中畑由紀、向井理英子、尾松達司、大洞昭博、小島孝雄、八木信明
- Organizer
  第24回日本がん免疫学会総会
- Data Source
  KAKENHI-PROJECT-20K07796
[Presentation] Metformin inhibits epithelial-mesenchymal transition in human pancreatic cancer cell lines2019
- Author(s)
  Juichiro Yoshida, Takeshi Ishikawa, Yuki Endo, Shinya Matsumura, Takayuki Ota,Katsura Mizushima, Yasuko Hirai, Tetsuya Okayama, Naoyuki Sakamoto, Ken Inoue, Kazuhiro Kamada, Kazuhiko Uchiyama, Tomohisa Takagi, Yuji Naito, Yoshito Ito
- Organizer
  American Association for Cancer Research(AACR) Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09314
[Presentation] 消化器癌に対する抗体薬の治療効果増強および治療抵抗性克服を目指した新たな細胞療法の開発2019
- Author(s)
  石川剛、岡山哲也、坂元直行
- Organizer
  第105回日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-17K09314
[Presentation] Safety and efficacy of high purity and activity NK cells therapy in combination with IgG1 antibody in patients with gastric or colorectal cancer: A phase I clinical trial2018
- Author(s)
  Sakamoto N, Ishikawa T, Okayama T, Ideno M, Oka K, Enoki T, Mineno J, Konishi H, Kokura S, Naito Y, Itoh Y.
- Organizer
  American Association for Cancer Research (AACR) Annual Meeting 2018. https://webcast.aacr.org/s/2018annual/CTPL04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09274
[Presentation] Phase Ⅰ clinical trial of NK cell therapy combined with IgG1 antibody in patients with gastric or colorectal cancer2018
- Author(s)
  坂元直行、石川　剛、岡山哲也、出野美津子、榎　竜嗣、峰野純一、内藤裕二、伊藤義人
- Organizer
  第22回日本がん免疫学会総会
- Data Source
  KAKENHI-PROJECT-16K09274
[Presentation] 抗癌剤は膵癌細胞株のPD-L1発現を増強し、温熱処理は抗癌剤誘導PD-L1発現を抑制する2015
- Author(s)
  土井俊文、石川剛、岡要、安田知代、岡山哲也、坂元直行、鎌田和浩、堅田和弘、内山和彦、半田修、高木智久、内藤裕二、伊藤義人
- Organizer
  第28回日本バイオセラピィ学会学術集会総会
- Place of Presentation
  川越
- Year and Date
  2015-12-03
- Data Source
  KAKENHI-PROJECT-26460914
[Presentation] Elevated levels of plasma VEGF associated with the attenuation of whole blood IFN-γ production and QOL impairment in patients with advanced gastric cancer.2015
- Author(s)
  Naoyuki Sakamoto, Takeshi Ishikawa, Toshihumi Doi, Tetsuya Okayama, Hideyuki Konishi, Satoshi Kokura, Yuji Naito, Yoshito Ito, Toshikazu Yoshikawa
- Organizer
  106th Annual Meeting of the American Association for Cancer Research
- Place of Presentation
  Philadelphia
- Year and Date
  2015-04-20
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460914
[Presentation] The influence of anticancer agents and hyperthermia on PD-L1 expression on human and murine pancreatic cancer cell lines.2015
- Author(s)
  Toshifumi Doi, Tetsuya Okayama, Takeshi Ishikawa, Kaname Oka, Naoyuki Sakamoto, Yuji Naito, Yoshito Itoh
- Organizer
  106th Annual Meeting of the American Association for Cancer Research
- Place of Presentation
  Philadelphia
- Year and Date
  2015-04-20
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460914
[Presentation] The influence of anticancer agents and heat treatment on PD-L1 expression on pancreatic cancer cell lines2015
- Author(s)
  岡要、土井俊文、石川剛、岡山哲也、安田知代、坂元直行、堅田和弘、鎌田和浩、内山和彦、半田修、高木智久、内藤裕二、伊藤義人
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2015-10-09
- Data Source
  KAKENHI-PROJECT-26460914
[Presentation] A novel expansion method for functional natural killer cells and its clinical applicatio.2015
- Author(s)
  Takeshi Ishikawa, Naoyuki Sakamoto, Tetsuya Okayama , Satoshi Kokura, Mitsuko Ideno, Akiko Kato, Tatsuji Enoki,, Masanari Kitagawa, Junichi Mineno, Tomoyo Yasuda, Toshifumi Doi, Yuji Naito, Yoshito Itoh, Toshikazu Yoshikawa
- Organizer
  106th Annual Meeting of the American Association for Cancer Research
- Place of Presentation
  Philadelphia
- Year and Date
  2015-04-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460914
[Presentation] 行・再発消化器がんを対象とした新規培養法を用いた高純度NK細胞療法の第I相臨床試2014
- Author(s)
  坂元直行、石川剛、岡山哲也、出野美津子、榎竜嗣、峰野純一、古倉聡、内藤裕二、伊藤義人、吉川敏一
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2014-09-25
- Data Source
  KAKENHI-PROJECT-26460914
[Presentation] NK細胞を用いた胃癌に対するTrastuzumabの抗腫瘍効果増強についての検討2014
- Author(s)
  岡山哲也, 石川剛, 坂元直行, 古倉聡, 出野美津子, 加藤彰子, 榎竜嗣, 峰野純一, 吉田直久, 鎌田和浩, 堅田和弘, 内山和彦, 半田修, 高木智久, 小西英幸, 八木信明, 内藤裕二, 吉川敏一, 伊藤義人
- Organizer
  第54回日本消化器病学会大会
- Place of Presentation
  神戸
- Year and Date
  2014-10-24
- Data Source
  KAKENHI-PROJECT-26460914
[Presentation] Advantages and clinical application of fibronectin CH296-stimulated T cells in cancer immunotherapy2014
- Author(s)
  Ishikawa T, Kokura S, Okayama T, Sakamoto N, Ideno M, Muraki N, Kato A, Enoki T, Mineno J, Naito Y, Itoh Y, Yoshikawa T.
- Organizer
  105th Annual Meeting of the American Association for Cancer Research
- Place of Presentation
  San Diego, CA
- Year and Date
  2014-04-07
- Data Source
  KAKENHI-PROJECT-26460914
[Presentation] High purity and activity NK cells therapy in patients with advanced gastrointestinal cancer: Phase I study2014
- Author(s)
  Okayama T, Kokura S, Ishikawa T, Sakamoto N, Ideno M, Sakai F, Kato A, Enoki T, Mineno J, Konishi H, Naito Y, Itoh Y, Yoshikawa T.
- Organizer
  105th Annual Meeting of the American Association for Cancer Research
- Place of Presentation
  San Diego, CA
- Year and Date
  2014-04-07
- Data Source
  KAKENHI-PROJECT-26460914
[Presentation] CTLA-4阻害薬は分化型よりも未分化型T細胞を用いた養子免疫療法との併用においてより強い効果を発揮する2014
- Author(s)
  石川剛、足立聡子、岡山哲也、岡要、土井俊文、坂元直行、鎌田和浩、内山和彦、半田修、高木智久、古倉聡、内藤裕二、伊藤義人
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2014-09-25
- Data Source
  KAKENHI-PROJECT-26460914

1. Ishikawa Takeshi (90372846)

# of Collaborated Projects: 4 results

# of Collaborated Products: 21 results
2. 岡山哲也 (30636535)

# of Collaborated Projects: 3 results

# of Collaborated Products: 20 results
3. 内藤裕二 (00305575)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
4. 八木信明 (40536439)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
5. KOKURA Satoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Sakamoto Naoyuki 坂元 直行

Research Projects

Research Products

Co-Researchers

The development of integrated symptom management intervention making full use of Immune-radiotherapy plus chemotherapy in patients with advanced cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of new therapeutic strategies for cancer cachexia targeting gut microbiota

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The development of stratification tool to assess disease-specific health-related QOL in patients with advanced incurable cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of novel immune cell therapy combined with immune checkpoint inhibitors

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Metformin inhibits TGF-β1-induced epithelial-mesenchymal transition and liver metastasis of pancreatic cancer cells2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Skeletal muscle mass as a predictor of the response to neo-adjuvant chemotherapy in locally advanced esophageal cancer.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Clinical significance of soluble forms of immune checkpoint molecules in advanced esophageal cancer2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Phase I clinical trial of adoptive transfer of expanded natural killer cells in combination with IgG1 antibody in patients with gastric or colorectal cancer.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The JAK/STAT pathway is involved in the upregulation of PD-L1 expression in pancreatic cancer cell lines.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Tumor inoculation site affects the development of cancer cachexia and muscle wasting.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Phase I clinical trial of autologous NK cell therapy using novel expansion method in patients with advanced digestive cancer.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cytotoxic T lymphocyte-associated antigen 4 inhibition increases the antitumor activity of adoptive T-cell therapy when carried out with naïve rather than differentiated T cells.2015

Author(s)

Journal Title

DOI

Data Source

[Presentation] 消化管がんにおけるミスマッチ修復蛋白IHC検査のリアルワールドデータ；免疫療法における個別化医療の実践を目指して2024

Author(s)

Organizer

Data Source

[Presentation] 同時性、および異時性多発胃癌の内視鏡的治療と成績2023

Author(s)

Organizer

Data Source

[Presentation] ミスマッチ修復蛋白IHC検査のリアルワールドデータが可視化するがん免疫療法における適切な患者選択の重要性2023

Author(s)

Organizer

Data Source

Sakamoto Naoyuki 坂元直行