YAKUSHIJI Fumika 薬師寺文華

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Yakushiji Fumika 薬師寺文華

薬師寺文華ヤクシジフミカ

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Researcher Number	40548476
Other IDs
Affiliation (Current)	2025: 長崎大学, 医歯薬学総合研究科(薬学系), 教授
Affiliation (based on the past Project Information) *help	2021 – 2023: 北海道大学, 薬学研究院, 准教授 2018 – 2020: 北海道大学, 薬学研究院, 講師 2016: 北海道大学, 薬学研究院, 講師 2009 – 2012: Tokyo University of Pharmacy and Life Science, 薬学部, 助教
Review Section/Research Field	Principal Investigator Drug development chemistry / Basic Section 37030:Chemical biology-related / Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related Except Principal Investigator Medium-sized Section 47:Pharmaceutical sciences and related fields
Keywords	Principal Investigator ヒストンメチル化 / ケミカルエピジェネティクス / アミノ酸残基選択的化学修飾 / ドライバー遺伝子変異 / RNAポリメラーゼ / ハイブリッド / タンパク質化学修飾 / メチオニン / ヒストン変異体 / エピゲノム創薬 … More / 低分子化合物 / リジンメチル化 / ヒストン / エピジェネティクス / スクリーニング / ヒストン変異 / ポリコーム抑制複合体２ / ホロマイシン / ミキソピロニン / RNA ポリメラーゼ / ホロチン / 抗菌活性剤 / 分子モデリング / 機能性分子 / Thiomarinol / Myxopyronin / Holothin / 抗菌活性 … More Except Principal Investigator 創薬化学 / アトロプ異性体 / チオアミド / アミド / 軸不斉 / アトロプ異性 / 活性配座 Less

Artificial post-translational modifications at a mutated amino acid residue for alteration of the protein functionPrincipal Investigator
- Principal Investigator
  
  薬師寺文華
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 37030:Chemical biology-related
- Research Institution
  Hokkaido University
Chemical epigenetics for targeting driver mutationsPrincipal Investigator
- Principal Investigator
  
  Yakushiji Fumika
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  Hokkaido University
Development of a quick and simple search method for active conformations with amplification and memory of active conformations as the key concept
- Principal Investigator
  
  Ichikawa Satoshi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  Hokkaido University
Chemical epigenetics of histone mutations in cancer: development of lysine methyltransferase modulatorsPrincipal Investigator
- Principal Investigator
  
  Yakushiji Fumika
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  Hokkaido University
機能性ホロチン分子に着目した新規ハイブリッド型抗菌剤創製研究Principal Investigator
- Principal Investigator
  
  薬師寺文華
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  Tokyo University of Pharmacy and Life Science
Natural Product Hybrids : Design, Synthesis and Evaluation of Novel Antimicrobial AgentsPrincipal Investigator
- Principal Investigator
  
  YAKUSHIJI Fumika
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Drug development chemistry
- Research Institution
  Tokyo University of Pharmacy and Life Science

All 2023 2022 2021 2020 2019 2018 2013 2012 2011 2010 2009

All Journal Article Presentation Patent

[Journal Article] Synthetic Modifications of Histones and Their Functional Evaluation2022
- Author(s)
  Moe Toyobe, Fumika Yakushiji
- Journal Title
  
  Chem. Asian J.
  
  Volume: 17 Issue: 13
- DOI
  10.1002/asia.202200197
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K06988
[Journal Article] Polycomb Repressive Complex 2: Modulator Development for Functional Regulation of a Multiprotein Complex by Using Structural Information2019
- Author(s)
  Yasuaki Tokodai, Fumika Yakushiji
- Journal Title
  
  ChemBioChem
  
  Volume: 20 Issue: 16 Pages: 2046-2053
- DOI
  10.1002/cbic.201900212
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K06988
[Journal Article] Development of positive modulators of histone H3K27 methylation2018
- Author(s)
  Tokodai, Yasuaki; Yakushiji, Fumika; Sengoku, Toru; Katsuyama, Akira; Ichikawa, Satoshi
- Journal Title
  
  Peptide Science
  
  Volume: 1 Pages: 14-14
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K18913
[Journal Article] Novel Hybrid-Type Antimicrobial Agents Targeting the Switch Region of Bacterial RNA Polymerase2013
- Author(s)
  Yakushiji, F.; Miyamoto, Y.; Kunoh, Y.; Okamoto, R.; Nakaminami, H.; Yamazaki, Y.; Noguchi, N.; Hayashi, Y.
- Journal Title
  
  ACS Medicinal Chemistry Letters
  
  Volume: 4 Issue: 2 Pages: 220-224
- DOI
  10.1021/ml300350p
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790142
[Journal Article] Synthesis and Structure-Activity Relationship Study of Antimicrotubule Agents Phenylahistin Derivatives with a Didehydropiperazine-2,5-dione Structure2012
- Author(s)
  Y.Yamazaki
- Journal Title
  
  Journal of Medicinal Chemistry
  
  Volume: 55 Issue: 3 Pages: 1056-1071
- DOI
  10.1021/jm2009088
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-23102013, KAKENHI-PROJECT-23390029, KAKENHI-PROJECT-23790142, KAKENHI-PROJECT-23790143
[Journal Article] Negamycin Analogue with Readthrough-Promoting Activity as a Potential Drug Candidate for Duchenne Muscular Dystrophy2012
- Author(s)
  Akihiro Taguchi, Masataka Shiozuka, Ryoichi Matsuda, Yoshiaki Nonomura, Yoshiaki Kiso, Yuri Yamazaki, Fumika Yakushiji, Yoshio Hayashi et al.
- Journal Title
  
  ACS Med. Chem. Lett.
  
  Volume: 3 Issue: 2 Pages: 118-122
- DOI
  10.1021/ml200245t
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790142, KAKENHI-PROJECT-23790143
[Journal Article] Development of a solidsupported biotinylation reagent for efficient biotin labeling of SH groups on small molecules2012
- Author(s)
  Kentarou Fukumoto, Kumi Adachi, Akihiro Kajiyama, Yuri Yamazaki, Fumika Yakushiji, Yoshio Hayashi
- Journal Title
  
  Tetrahedron Lett
  
  Volume: 53 Issue: 5 Pages: 535-538
- DOI
  10.1016/j.tetlet.2011.11.089
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659059, KAKENHI-PROJECT-23790142, KAKENHI-PROJECT-23790143
[Journal Article] Water-Soluble Prodrug of Antimicrotubule Agent Plinabulin : Effective strategy with Click Chemistry2011
- Author(s)
  Fumika Yakushiji, Yoshio Hayashi, 他4人
- Journal Title
  
  Chemistry-A European Journal
  
  Volume: 17 Issue: 45 Pages: 12587-12590
- DOI
  10.1002/chem.201102293
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390029, KAKENHI-PROJECT-23790142
[Journal Article] Tubulin photoaffinity labeling study with a plinabulin chemical probe possessing a biotin tag at the oxazole2011
- Author(s)
  Yamazaki Y., Kido Y., Hidaka K., Yasui H., Kiso Y., Yakushiji F., Hayashi Y.
- Journal Title
  
  Bioorg.Med.Chem. 19
  
  Pages: 595-602
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21890262
[Journal Article] Tubulin photoaffinity labeling study with a plinabulin chemical probe possessing a biotin tag at the oxazole2011
- Author(s)
  Yamazaki, Y., Kido, Y., Hidaka, K., Yasui, H., Kiso, Y., Yakushiji, F., Hayashi, Y.
- Journal Title
  
  Bioorganic Medicinal Chemistry
  
  Volume: 19 Pages: 595-602
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21890262
[Journal Article] 温故知新：アミド結合形成の新展開2011
- Author(s)
  薬師寺文華
- Journal Title
  
  有機合成化学協会誌
  
  Volume: 69 Pages: 715-716
- NAID
  10028294191
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790142
[Journal Article] Total Synthesis of (+)-Negamycin and Its 5-epi-Derivative2010
- Author(s)
  Shigenobu Nishiguchi, Magne O.Sydnes, Akihiro Taguchi, Thomas Regnier, Tetsuya Kajimoto, Manabu Node, Yuri Yamazaki, Fumika Yakushiji, Yoshiaki Kiso, Yoshio Hayashi
- Journal Title
  
  Tetrahedron 66
  
  Pages: 314-320
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21890262
[Journal Article] Total Synthesis of (+)-Negamycin and Its 5-epi-Derivative2010
- Author(s)
  Nishiguchi S., Sydnes O.M., Taguchi A., Regnier T., Kajimoto T., Node M., Yamazaki Y., Yakushiji F., Kiso Y., Hayashi Y.
- Journal Title
  
  Tetrahedron 66
  
  Pages: 314-320
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21890262
[Patent] ミキソピロニン誘導体含有抗菌剤2011
- Inventor(s)
  薬師寺文華
- Industrial Property Rights Holder
  薬師寺文華,林良雄
- Industrial Property Number
  2011-070428
- Filing Date
  2011-03-28
- Data Source
  KAKENHI-PROJECT-21890262
[Patent] ミキソピロニン誘導体含有抗菌剤2011
- Inventor(s)
  薬師寺文華
- Industrial Property Rights Holder
  薬師寺文華、林良雄
- Filing Date
  2011-03-31
- Data Source
  KAKENHI-PROJECT-21890262
[Patent] Plinabulin Prodrug Analogs and Therapeutic Uses Thereof2010
- Inventor(s)
  薬師寺文華、林良雄
- Industrial Property Rights Holder
  Yakushiji, F.; Hayashi, Y.; Yamazaki, Y.; Hironari, T.; Lloyd, K.; Reisman, J.; Palladino, M.; Melnick, E.R.
- Filing Date
  2010-09-23
- Overseas
- Data Source
  KAKENHI-PROJECT-21890262
[Presentation] ヒストンメチル化修飾制御化合物の創製研究2023
- Author(s)
  薬師寺文華
- Organizer
  第97回日本薬理学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-23K04956
[Presentation] ケミカルエピジェネティクスを基盤とした創薬研究2023
- Author(s)
  薬師寺文華
- Organizer
  日本薬学会第143年会
- Invited
- Data Source
  KAKENHI-PROJECT-19K06988
[Presentation] ヒストンメチル化酵素複合体を標的としたケミカルエピジェネティクス研究2023
- Author(s)
  薬師寺文華
- Organizer
  日本女性科学者の会新春シンポジウム2023
- Invited
- Data Source
  KAKENHI-PROJECT-19K06988
[Presentation] メチオニン残基選択的化学修飾法によるPRC2ヒストンメチル化能の制御2022
- Author(s)
  豊邉萌, 市川聡, 薬師寺文華
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-19K06988
[Presentation] 有機合成化学を基盤とした新規生物活性化合物の創製研究2022
- Author(s)
  薬師寺文華
- Organizer
  日本薬学会北海道支部第148例会
- Invited
- Data Source
  KAKENHI-PROJECT-19K06988
[Presentation] Development of PPI inhibitors for epigenetic regulation2022
- Author(s)
  Fumika Yakushiji
- Organizer
  第2回GSD/GI-CoRE国際シンポジウム
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06988
[Presentation] ヒストンメチル化酵素複合体の機能制御を指向した分子創製研究2021
- Author(s)
  薬師寺文華
- Organizer
  日本薬学会第141年会
- Invited
- Data Source
  KAKENHI-PROJECT-19K06988
[Presentation] Development of novel small molecules for medicinal chemistry research2020
- Author(s)
  Fumika Yakushiji
- Organizer
  7th SNU Mini-Symposium on Medicinal Chemistry
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06988
[Presentation] ヒストン修飾酵素複合体の機能制御を指向したケミカルエピジェネティクス研究2020
- Author(s)
  薬師寺文華
- Organizer
  第93回日本生化学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-19K06988
[Presentation] Development of positive modulators of the histone methyltransferase complex PRC22019
- Author(s)
  Fumika Yakushiji, Yasuaki Tokodai, Satoshi Ichikawa
- Organizer
  Gordon Research Conference (High Throughput Chemistry and Chemical Biology)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06988
[Presentation] ヒストンメチル化酵素複合体 PRC2 構成因子 EZH2-EED 相互作用阻害剤の創製研究2019
- Author(s)
  薬師寺文華, 塩田勇介, 加藤いづみ, 岡田ゆかり, 堀内正隆, 児玉耕太, 勝山彬, 松田彰, 前仲勝実, 市川聡
- Organizer
  第13回日本エピジェネティクス研究会年会
- Data Source
  KAKENHI-PROJECT-19K06988
[Presentation] Development of novel small molecules that disrupt the EZH2-EED interaction2019
- Author(s)
  Fumika Yakushiji, Yusuke Shioda, Izumi Kato, Masataka Horiuchi, Akira Matsuda, Katsumi Maenaka, Satoshi Ichikawa
- Organizer
  The 14th International Conference on Cutting-Edge Organic Chemistry in Asia
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06988
[Presentation] タンパク質複合体の機能制御を指向した分子創製研究2019
- Author(s)
  薬師寺文華
- Organizer
  第51回若手ペプチド夏の勉強会
- Invited
- Data Source
  KAKENHI-PROJECT-19K06988
[Presentation] ヒストンメチル化酵素複合体 PRC2 活性促進剤の創製研究2019
- Author(s)
  薬師寺文華, 戸子臺泰光, 仙石徹, 勝山彬, 市川聡
- Organizer
  日本ケミカルバイオロジー学会　第14回年会
- Data Source
  KAKENHI-PROJECT-19K06988
[Presentation] ヒストンH3K27メチル化酵素複合体PRC2活性化剤の創製研究2019
- Author(s)
  戸子臺泰光、薬師寺文華、仙谷徹、勝山彬、市川聡
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-16K18913
[Presentation] Development of positive modulators of histone H3K27 methylation2018
- Author(s)
  Yasuaki Tokodai, Fumika Yakushiji, Toru Sengoku, Akira Katsuyama, Satoshi Ichikawa
- Organizer
  10th International Peptide Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K18913
[Presentation] PRC2アロステリックアクティベーターの創製研究2018
- Author(s)
  戸子臺泰光、薬師寺文華、市川聡
- Organizer
  日本薬学会北海道支部第145回例会
- Data Source
  KAKENHI-PROJECT-16K18913
[Presentation] ペプチドを基盤としたヒストン H3K27 メチル化モジュレーターの創製研究2018
- Author(s)
  薬師寺文華、戸子臺泰光、市川聡
- Organizer
  日本ケミカルバイオロジー学会第 13 回年会
- Data Source
  KAKENHI-PROJECT-16K18913
[Presentation] ヒストン H3K27 メチル化モジュレーターの創製研究2018
- Author(s)
  薬師寺文華、戸子臺泰光、市川聡
- Organizer
  第12回日本エピジェネティクス研究会年会
- Data Source
  KAKENHI-PROJECT-16K18913
[Presentation] パラジウム触媒を用いた 3－アリール－4－ヒドロキシクマリンの効率的合成法の開発2013
- Author(s)
  薬師寺文華, 原茂正子, 宮寺友香里, 高山健太郎, 林良雄
- Organizer
  日本薬学会　第１３３年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23790142
[Presentation] C3-Selective arylation of 4-hydroxycoumarins with palladium catalysts2013
- Author(s)
  Fumika Yakushiji, Masako Haramo, Yukari Miyadera, Yoshio Hayashi
- Organizer
  245^<th> ACS National meeting & Exposition
- Place of Presentation
  New Orleans, USA
- Data Source
  KAKENHI-PROJECT-23790142
[Presentation] 細菌性 RNA ポリメラーゼを標的とした新規ハイブリッド型抗菌剤の創製研究2012
- Author(s)
  薬師寺文華，宮本裕子，久能佑樹，岡本玲子，山崎有理，林良雄
- Organizer
  第３０回メディシナルケミストリーシンポジウム
- Place of Presentation
  船堀
- Data Source
  KAKENHI-PROJECT-23790142
[Presentation] 位置選択的 C-H 活性化型アリール化反応による３－アリール－４－ヒドロキシクマリンの合成2012
- Author(s)
  薬師寺文華, 原茂正子, 宮寺友香里, 高山健太郎, 林良雄
- Organizer
  第３８回反応と合成の進歩シンポジウム
- Place of Presentation
  船堀
- Data Source
  KAKENHI-PROJECT-23790142
[Presentation] Design, Synthesis and Biological Evaluation of Hybrid-Type Derivatives of Myxopyronin as Inhibitors of Bacterial RNA Polymerase2012
- Author(s)
  Fumika Yakushiji, Reiko Okamoto, Yuki Kunoh, Yuko Miyamoto, Yuri Yamazaki, and Yoshio Hayashi
- Organizer
  ACS National Meeting & Exposition
- Place of Presentation
  San Diego, USA
- Data Source
  KAKENHI-PROJECT-23790142
[Presentation] Novel Hybrid-type Derivatives of Myxopyronin targetting the Bacterial Infections2012
- Author(s)
  Fumika Yakushiji, Yuki Kunoh, Yuko Miyamoto, Yuri Yamazaki, Yoshio Hayashi
- Organizer
  22nd International Symposium on Medicinal Chemistry
- Place of Presentation
  ベルリン
- Data Source
  KAKENHI-PROJECT-23790142
[Presentation] 機能性ホロチン分子に着目したハイブリッド型 RNA ポリメラーゼ阻害剤創製研究2012
- Author(s)
  薬師寺　文華
- Organizer
  有機合成薬学シンポジウム(招待講演)
- Place of Presentation
  徳島
- Data Source
  KAKENHI-PROJECT-23790142
[Presentation] ハイブリッド型ミキソピロニン類縁体による新世代抗菌活性剤創製研究2011
- Author(s)
  薬師寺文華,岡本玲子,久能佑樹,宮本裕子,山崎有理,林良雄
- Organizer
  第131回日本薬学会年会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-21890262
[Presentation] Huisgen反応を利用した血管遮断剤Plinabulin水溶性プロドラッグの創製2011
- Author(s)
  田中達也,薬師寺文華,岩橋孝祐,山崎有理,林良雄
- Organizer
  第131回日本薬学会年会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-21890262
[Presentation] 固相担持型SH基特異的ビオチニル化試薬の合成と低分子化合物への効率的ビオチン標識2011
- Author(s)
  足立久美, 福元謙太郎, 山崎有理, 薬師寺文華, 林良雄
- Organizer
  第131回日本薬学会年会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-21890262
[Presentation] 分子平面性を強化したDidehydro Tryprostatin誘導体の合成とその生物活性2011
- Author(s)
  篠崎雄希, 山本美彦, 嶽野遙, 山崎有理, 薬師寺文華, 林良雄
- Organizer
  第131回日本薬学会年会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-21890262
[Presentation] Design, Synthesis and Biological Evaluation of Novel Hybrid-Type Derivatives of Myxopyronin B as Antibacterial Agents2011
- Author(s)
  Fumika Yakushiji, Reiko Okamoto, Yuuki Kunoh, Yuko Miyamoto, Yuri Yamazaki, and Yoshio Hayashi
- Organizer
  23rd International Congress of Heterocyclic Chemistry
- Place of Presentation
  Glasgow, UK
- Data Source
  KAKENHI-PROJECT-23790142
[Presentation] Novel Hybrid Type Analogues of Myxopyronin B as Antimicrobial Agents2011
- Author(s)
  Fumika Yakushiji, Reiko Okamoto, Yuki Kunoh, Yuko Miyamoto, Yuri Yamazaki and Yoshio Hayashi
- Organizer
  8th AFMC International Medicinal Chemistry Symposium
- Place of Presentation
  Tokyo, Japan
- Data Source
  KAKENHI-PROJECT-23790142
[Presentation] ハイブリッド型ミキソピロニン類縁体の合成研究2010
- Author(s)
  薬師寺文華, 岡本玲子, 山崎有理, 林良雄
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-21890262
[Presentation] 「ハイブリッド型ミキソピロニン類縁体の合成研究2010
- Author(s)
  薬師寺文華,岡本玲子,山崎有理,林良雄
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-21890262
[Presentation] 新世代抗菌剤開発を指向したハイブリッド型ミキソピロニン類縁体の合成研究2010
- Author(s)
  薬師寺文華,岡本玲子,山崎有理,林良雄
- Organizer
  第29回メディシナルケミストリーシンポジウム
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-21890262
[Presentation] First Total Syntheses of Thiomarinols A and B2010
- Author(s)
  Fumika Yakushiji, Masahiro Yoshida, Jacques Maddaluno, Yoshio Hayashi, Kozo Shishido
- Organizer
  18th IUPAC International Conference on Organic Synthesis
- Place of Presentation
  ノルウェー、ベルゲン
- Data Source
  KAKENHI-PROJECT-21890262
[Presentation] Total Synthesis of Thiomarinols A and B2010
- Author(s)
  Fumika Yakushiji, Masahiro Yoshida, Jacques Maddaluno, Yoshio Hayashi, Kozo Shishido
- Organizer
  ACS Spring 2010 National Meeting & Exposition
- Place of Presentation
  San Francisco, USA
- Data Source
  KAKENHI-PROJECT-21890262
[Presentation] Total Synthesis of Thiomarinols A and B'2010
- Author(s)
  Yakushiji F., Yoshida M., Maddaluno J., Hayashi Y., Shishido K.
- Organizer
  ACS Spring 2010 National Meeting & Exposition
- Place of Presentation
  San Francisco, USA
- Data Source
  KAKENHI-PROJECT-21890262
[Presentation] First Total Syntheses of Thiomarinols A and B'2010
- Author(s)
  Yakushiji F., Yoshida M., Maddaluno J., Hayashi Y., Shishido K.
- Organizer
  18th IUPAC International Conference on Organic Synthesis
- Place of Presentation
  Bergen, Norway
- Data Source
  KAKENHI-PROJECT-21890262
[Presentation] 微小管重合阻害剤Plinabulinにおける水溶性プロドラッグの創製2010
- Author(s)
  薬師寺文華,田中達也,岩橋孝祐,山崎有理,林良雄
- Organizer
  第29回メディシナルケミストリーシンポジウム
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-21890262
[Presentation] 新世代抗菌剤開発を目的としたハイブリッド型ミキソピロニン誘導体合成研究2010
- Author(s)
  薬師寺文華, 岡本玲子, 山崎有理, 林良雄
- Organizer
  第9回国際バイオEXPO
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-21890262
[Presentation] ポリケチド由来生理活性天然物の全合成研究2009
- Author(s)
  薬師寺文華
- Organizer
  関東ペプチド研究会
- Place of Presentation
  東京医科歯科大学
- Year and Date
  2009-05-26
- Data Source
  KAKENHI-PROJECT-21890262
[Presentation] チオマリノールA及びBの全合成2009
- Author(s)
  薬師寺文華, 吉田昌裕, Jacques Maddaluno, 林良雄, 宍戸宏造
- Organizer
  第35回反応と合成の進歩シンポジウム
- Place of Presentation
  金沢
- Data Source
  KAKENHI-PROJECT-21890262
[Presentation] Synthesis of(+)-Negamycin and Derivatives2009
- Author(s)
  Fumika Yakushiji, Shigenobu Nishiguchi, Magne O.Sydnes, Akihiro Taguchi, Thomas Regnier, Tetsuya Kajimoto, Manabu Node, Yoshiaki Kiso, Yuri Yamazaki, Yoshio Hayashi
- Organizer
  3^<rd> Asia-Pasific International Peptide Synposium
- Place of Presentation
  Jeju, KOREA
- Data Source
  KAKENHI-PROJECT-21890262
[Presentation] Synthesis of (+)-Negamycin and Derivatives2009
- Author(s)
  Yakushiji F., Nishiguchi S., Sydnes O.M., Taguchi A., Regnier T., Kajimoto T., Node M., Kiso Y., Yamazaki Y., Hayashi Y.
- Organizer
  3^<rd> Asia-Pasific International Peptide Synposium
- Place of Presentation
  Jeju, KOREA
- Data Source
  KAKENHI-PROJECT-21890262

1. Ichikawa Satoshi (60333621)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 勝山彬 (20824709)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 林良雄

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

YAKUSHIJI Fumika 薬師寺 文華

Yakushiji Fumika 薬師寺 文華

薬師寺 文華 ヤクシジ フミカ

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Artificial post-translational modifications at a mutated amino acid residue for alteration of the protein functionPrincipal Investigator

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Chemical epigenetics for targeting driver mutationsPrincipal Investigator

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Development of a quick and simple search method for active conformations with amplification and memory of active conformations as the key concept

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Chemical epigenetics of histone mutations in cancer: development of lysine methyltransferase modulatorsPrincipal Investigator

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機能性ホロチン分子に着目した新規ハイブリッド型抗菌剤創製研究Principal Investigator

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Natural Product Hybrids : Design, Synthesis and Evaluation of Novel Antimicrobial AgentsPrincipal Investigator

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[Journal Article] Synthetic Modifications of Histones and Their Functional Evaluation2022

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[Journal Article] Polycomb Repressive Complex 2: Modulator Development for Functional Regulation of a Multiprotein Complex by Using Structural Information2019

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[Journal Article] Development of positive modulators of histone H3K27 methylation2018

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[Journal Article] Novel Hybrid-Type Antimicrobial Agents Targeting the Switch Region of Bacterial RNA Polymerase2013

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[Journal Article] Synthesis and Structure-Activity Relationship Study of Antimicrotubule Agents Phenylahistin Derivatives with a Didehydropiperazine-2,5-dione Structure2012

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[Journal Article] Negamycin Analogue with Readthrough-Promoting Activity as a Potential Drug Candidate for Duchenne Muscular Dystrophy2012

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[Journal Article] Development of a solidsupported biotinylation reagent for efficient biotin labeling of SH groups on small molecules2012

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[Journal Article] Water-Soluble Prodrug of Antimicrotubule Agent Plinabulin : Effective strategy with Click Chemistry2011

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YAKUSHIJI Fumika 薬師寺文華

Yakushiji Fumika 薬師寺文華

薬師寺文華ヤクシジフミカ

[Journal Article] 温故知新：アミド結合形成の新展開2011