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shiimura yuki  椎村 祐樹

… Alternative Names

Shiimura Yuki  椎村 祐樹

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Researcher Number 40551297
Other IDs
  • ORCIDhttps://orcid.org/0000-0002-9752-7399
Affiliation (Current) 2025: 久留米大学, 付置研究所, 助教
2025: 京都大学, 医学研究科, 客員研究員
Affiliation (based on the past Project Information) *help 2018 – 2024: 久留米大学, 付置研究所, 助教
2017: 京都大学, 医学研究科, 客員研究員
2016: 京都大学, 医学研究科, 特定研究員
Review Section/Research Field
Principal Investigator
Basic Section 54040:Metabolism and endocrinology-related / Basic Section 43020:Structural biochemistry-related / Functional biochemistry
Except Principal Investigator
Basic Section 43020:Structural biochemistry-related / Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
Keywords
Principal Investigator
構造生物学 / GPCR / グレリン受容体 / 立体構造 / 立体構造認識抗体 / グレリン / 構造解析 / アシルトランスフェラーゼ / グレリンOアシルトランスフェラーゼ / グレリンO-アシルトランスフェラーゼ … More / Cryo-EM / 結晶構造解析 / GHSR / 抗体 / X線結晶構造解析 … More
Except Principal Investigator
クライオ電子顕微鏡 / グレリン受容体 / アレスチン / Gタンパク質 / ケモカイン / クラスA GPCR / バイスシグナリング / 単粒子解析 / バイアスシグナリング / Gタンパク質共役受容体 / 脂肪酸修飾 / 構造解析 / ペプチドホルモン / フェニルアラニン・クラスター / X線結晶構造解析 / オクタン酸 / 脂肪酸 / ギャップ構造 / がん悪液質 / アナモレリン / 結晶構造解析 / 立体構造 / GPCR / グレリン Less
  • Research Projects

    (7 results)
  • Research Products

    (19 results)
  • Co-Researchers

    (5 People)
  •  Structural study of the initial transducer engagement by GPCR

    • Principal Investigator
      堤 尚孝
    • Project Period (FY)
      2024 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 43020:Structural biochemistry-related
    • Research Institution
      Okayama University
  •  膜結合型酵素によるグレリン活性化機構の解明Principal Investigator

    • Principal Investigator
      椎村 祐樹
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 43020:Structural biochemistry-related
    • Research Institution
      Kurume University
  •  グレリン受容体のシグナル伝達選択機構の構造基盤

    • Principal Investigator
      浅田 秀基
    • Project Period (FY)
      2022 – 2025
    • Research Category
      Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
    • Review Section
      Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
    • Research Institution
      Kyoto University
  •  Cryo-EM structure of the ghrelin receptor coupled to an engineered heterotrimeric G proteinPrincipal Investigator

    • Principal Investigator
      Shiimura Yuki
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Fund for the Promotion of Joint International Research (Fostering Joint International Research (A))
    • Review Section
      Basic Section 54040:Metabolism and endocrinology-related
    • Research Institution
      Kurume University
  •  Why is the acyl-modification of ghrelin necessary for activity?

    • Principal Investigator
      Masayasu Kojima
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 43020:Structural biochemistry-related
    • Research Institution
      Kurume University
  •  Crystal Structure Analysis of Ghrelin ReceptorPrincipal Investigator

    • Principal Investigator
      Shiimura Yuki
    • Project Period (FY)
      2018 – 2021
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 54040:Metabolism and endocrinology-related
    • Research Institution
      Kurume University
  •  Establishment of anti-ghrelin receptor antibodies for crystallizationPrincipal Investigator

    • Principal Investigator
      Shiimura Yuki
    • Project Period (FY)
      2016 – 2017
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Functional biochemistry
    • Research Institution
      Kyoto University

All 2024 2023 2022 2021 2020 2019 2018 2016

All Journal Article Presentation Book

  • [Book] 循環器内科2022

    • Author(s)
      佐藤貴弘、井田隆徳、椎村祐樹、児島将康
    • Total Pages
      6
    • Publisher
      科学評論社
    • Data Source
      KAKENHI-PROJECT-20KK0359
  • [Journal Article] Insights Into the Regulation of Offspring Growth by Maternally Derived Ghrelin.2022

    • Author(s)
      Sato T, Ida T, Shiimura Y, Matsui K, Oishi K, Kojima M.
    • Journal Title

      Front Endocrinol (Lausanne)

      Volume: 13 Pages: 852636-852636

    • DOI

      10.3389/fendo.2022.852636

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K06531, KAKENHI-PROJECT-20K08898, KAKENHI-PROJECT-21K05958, KAKENHI-PROJECT-20KK0359
  • [Journal Article] Expression of the ghrelin/growth hormone secretagogue receptor axis and its functional role in promoting tumor growth in primary central nervous system lymphomas2020

    • Author(s)
      Muta Hiroko、Sugita Yasuo、Furuta Takuya、Shiimura Yuki、Ohshima Koichi、Nakashima Kazutaka、Sato Kensaku、Morioka Motohiro、Abe Hideyuki、Nozawa Takanori、Fujii Yukihiko、Kakita Akiyoshi
    • Journal Title

      Neuropathology

      Volume: - Issue: 3 Pages: 232-239

    • DOI

      10.1111/neup.12634

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K16217, KAKENHI-PROJECT-17K10888, KAKENHI-PROJECT-18K08955
  • [Journal Article] The Crystal Structure of Angiotensin II Type 2 Receptor with Endogenous Peptide Hormone2020

    • Author(s)
      Asada Hidetsugu、Inoue Asuka、Ngako Kadji Francois Marie、Hirata Kunio、Shiimura Yuki、Im Dohyun、Shimamura Tatsuro、Nomura Norimichi、Iwanari Hiroko、Hamakubo Takao、Kusano-Arai Osamu、Hisano Hiromi、Uemura Tomoko、Suno Chiyo、Aoki Junken、Iwata So
    • Journal Title

      Structure

      Volume: 28 Issue: 4 Pages: 418-425.e4

    • DOI

      10.1016/j.str.2019.12.003

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K05334, KAKENHI-PROJECT-18K16217, KAKENHI-PROJECT-19H00923, KAKENHI-PROJECT-17K08264, KAKENHI-PROJECT-17K19349, KAKENHI-PROJECT-20K21392, KAKENHI-PLANNED-19H05777, KAKENHI-PROJECT-18H02388
  • [Journal Article] Structure of an antagonist-bound ghrelin receptor reveals possible ghrelin recognition mode2020

    • Author(s)
      Shiimura Yuki、Horita Shoichiro、Hamamoto Akie、Asada Hidetsugu、Hirata Kunio、Tanaka Misuzu、Mori Kenji、Uemura Tomoko、Kobayashi Takuya、Iwata So、Kojima Masayasu
    • Journal Title

      Nature Communications

      Volume: 11 Issue: 1 Pages: 1-9

    • DOI

      10.1038/s41467-020-17554-1

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K06531, KAKENHI-PROJECT-18K16217, KAKENHI-PROJECT-19H00923, KAKENHI-PROJECT-18K08497, KAKENHI-PROJECT-19K20143, KAKENHI-PLANNED-19H05777
  • [Presentation] グレリン受容体のリガンド認識機構および活性化機構の構造学的洞察.2024

    • Author(s)
      椎村祐樹、林到炫、浅田秀基、松井一真、岩田想、児島将康.
    • Organizer
      日本薬学会第144年会.
    • Data Source
      KAKENHI-PROJECT-20KK0359
  • [Presentation] Insights into the structure of the agonist-bound ghrelin receptor.2023

    • Author(s)
      Yuki Shiimura, Dohyun Im, Ryosuke Tany, Ryoji Kise, Hidetsugu Asada, So Iwata, Masuho Ikuo, Masayasu Kojima.
    • Organizer
      第96回日本内分泌学会学術総会.
    • Data Source
      KAKENHI-PROJECT-20KK0359
  • [Presentation] グレリン受容体のリガンド認識機構の構造基盤.2023

    • Author(s)
      椎村祐樹.
    • Organizer
      第27回日本心血管内分泌代謝学会学術総会.
    • Data Source
      KAKENHI-PROJECT-20KK0359
  • [Presentation] 構造情報に基づいたグレリン受容体アゴニストのシグナル活性の比較.2023

    • Author(s)
      椎村祐樹、林到炫、谷猪遼介、浅田秀基、増保生郎、松井一真、岩田想、児島将康.
    • Organizer
      第49回神経内分泌学会.
    • Data Source
      KAKENHI-PROJECT-20KK0359
  • [Presentation] The structural feature of ghrelin receptor.2023

    • Author(s)
      Yuki Shiimura, Dohyun Im, Ryosuke Tany, Hidetsugu Asada, Kazuma Matsui, Masuho Ikuo, So Iwata, Masayasu Kojima.
    • Organizer
      第44回日本肥満学会・第41回日本肥満症治療学会学術集会. 日韓台合同シンポジウム
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20KK0359
  • [Presentation] Structure of an antagonist-bound ghrelin receptor2022

    • Author(s)
      Y. Shiimura, S. Horita, A. Hamamoto, H. Asada, K. Hirata, K. Mori, T. Kobayashi, S. Iwata and M. Kojima
    • Organizer
      Keystone symposia
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20KK0359
  • [Presentation] The cryo-EM structure of an agonist bound ghrelin receptor2022

    • Author(s)
      椎村祐樹、林到炫、朝田秀基、岩田想、児島将康
    • Organizer
      心血管内分泌代謝学会
    • Data Source
      KAKENHI-PROJECT-20KK0359
  • [Presentation] Structure of an antagonist-bound ghrelin receptor2022

    • Author(s)
      Shiimura Yuki, Horita Shoichiro, Hamamoto Akie, Asada Hidetsugu, Hirata Kunio, Mori Kenji, Kobayashi Takuya, Iwata So, Kojima Masayasu
    • Organizer
      Keystone Symposia 2022
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K16217
  • [Presentation] グレリン受容体の立体構造解析2021

    • Author(s)
      椎村祐樹、浅田秀基、岩田想、児島将康
    • Organizer
      心血管内分泌学会
    • Data Source
      KAKENHI-PROJECT-18K16217
  • [Presentation] グレリン受容体のX線結晶構造解析2019

    • Author(s)
      椎村祐樹, 堀田彰一朗, 浅田秀基, 濱本明恵, 田中みすず, 平田邦生, 小林拓也, 岩田想, 児島将康.
    • Organizer
      第15回GPCR研究会
    • Data Source
      KAKENHI-PROJECT-18K16217
  • [Presentation] X線結晶構造解析を基盤とした活性型グレリン認識機構の解明2019

    • Author(s)
      椎村祐樹, 堀田彰一朗, 浅田秀基, 平田邦生, 小林拓也, 児島将康, 岩田想
    • Organizer
      日本薬学会第126回年会
    • Data Source
      KAKENHI-PROJECT-18K16217
  • [Presentation] Establishment of anti-ghrelin receptor antibodies for crystallization2018

    • Author(s)
      Y. Shiimura, S. Horita, H. Asada, T. Kobayashi, S. Iwata, and M. Kojima
    • Organizer
      Keystone symposia on molecular and cellular biology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K18515
  • [Presentation] グレリン受容体の結晶構造解析による活性型グレリン認識機構の解明2018

    • Author(s)
      椎村祐樹, 堀田彰一朗, 浅田秀基, 平田邦生, 小林拓也, 児島将康, 岩田想
    • Organizer
      第91回日本内分泌学会学術総会
    • Data Source
      KAKENHI-PROJECT-18K16217
  • [Presentation] GHSR結晶化にむけた安定化変異体の作製2016

    • Author(s)
      椎村祐樹、小林拓也、児島将康、岩田想
    • Organizer
      第7回ペプチド・ホルモン研究会
    • Place of Presentation
      久留米
    • Year and Date
      2016-09-17
    • Data Source
      KAKENHI-PROJECT-16K18515
  • 1.  堤 尚孝 (70963495)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 2.  Masayasu Kojima (20202062)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 3.  浅田 秀基 (20399041)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  林 到ヒョン (50721883)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  野村 紀通
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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