IMAMURA Hiroshi 今村比呂志

Researcher Number	40552485
Other IDs
Affiliation (Current)	2025: 長浜バイオ大学, バイオサイエンス学部, 助教
Affiliation (based on the past Project Information) *help	2022 – 2025: 長浜バイオ大学, バイオサイエンス学部, 助教 2021: 立命館大学, 生命科学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related Except Principal Investigator Basic Section 28010:Nanometer-scale chemistry-related
Keywords	Principal Investigator 抗体 / 変性 / 凝集 / 物理劣化 / 蛋白質医薬品 Except Principal Investigator メゾスケール凝集 / 相互作用ポテンシャル / 不均一凝集 / 小角散乱 / ペアポテンシャル / 治療薬徐放作用 / 高分子ナノミセル

医薬品抗体の変性構造の解明Principal Investigator
- Principal Investigator
  
  今村比呂志
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
- Research Institution
  Nagahama Institute of Bio-Science and Technology
Study on the origin of sustained drug releasability of polymeric nanomicelles based on clarifying the interaction potential surface
- Principal Investigator
  
  森田剛
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 28010:Nanometer-scale chemistry-related
- Research Institution
  Chiba University
Studies for early prediction of physical degradation of therapeutic proteinsPrincipal Investigator
- Principal Investigator
  
  今村比呂志
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
- Research Institution
  Nagahama Institute of Bio-Science and Technology
  Ritsumeikan University

All 2024 2023 2022 2021

All Journal Article Presentation Book

[Book] タンパク質の構造解析手法とIn silicoスクリーニングへの応用事例2023
- Author(s)
  墨智成、今村比呂志
- Total Pages
  530
- Publisher
  技術情報協会
- ISBN
  9784861049712
- Data Source
  KAKENHI-PROJECT-21K06503
[Book] 品質評価のカギをにぎる　バイオ医薬品の分析法 (津本、石井、内山、本田編)2022
- Author(s)
  本田真也、今村比呂志
- Total Pages
  180
- Publisher
  じほう
- ISBN
  4840754608
- Data Source
  KAKENHI-PROJECT-21K06503
[Journal Article] A student experiment to realize protein charge via ion-exchange chromatography of lysozyme and Nakamura effect2024
- Author(s)
  今村比呂志、神村麻友、川瀬雅也
- Journal Title
  
  Seibutsu-kogaku Kaishi
  
  Volume: 102 Issue: 2 Pages: 67-75
- DOI
  10.34565/seibutsukogaku.102.2_67
- ISSN
  0919-3758, 2435-8630
- Year and Date
  2024-02-25
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K06503
[Journal Article] Mechanistic Modeling of Amyloid Oligomer and Protofibril Formation in Bovine Insulin2024
- Author(s)
  Yuzu Keisuke、Imamura Hiroshi、Nozaki Takuro、Fujii Yuki、Badawy Shaymaa Mohamed Mohamed、Morishima Ken、Okuda Aya、Inoue Rintaro、Sugiyama Masaaki、Chatani Eri
- Journal Title
  
  Journal of Molecular Biology
  
  Volume: 436 Issue: 6 Pages: 168461-168461
- DOI
  10.1016/j.jmb.2024.168461
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06503, KAKENHI-PROJECT-22KJ2255, KAKENHI-PROJECT-19KK0071, KAKENHI-PROJECT-20H03224
[Journal Article] Energy Transfer on Cytoskeleton of Red Blood Cell Ghosts and their Efficiency Control by KCl Concentration‐induced Cell Shrinkage2024
- Author(s)
  Hiroe Haruka、Kawamoto Masashi、Imamura Hiroshi、Koshiyama Tomomi
- Journal Title
  
  Chemistry - A European Journal
  
  Volume: 30 Issue: 18
- DOI
  10.1002/chem.202303749
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06503, KAKENHI-PROJECT-22K05133
[Journal Article] Mechanistic modeling of amyloid oligomer and protofibril formation2023
- Author(s)
  Yuzu Keisuke、Imamura Hiroshi、Nozaki Takuro、Fujii Yuki、Mohamed Badawy Shaymaa Mohamed、Morishima Ken、Okuda Aya、Inoue Rintaro、Sugiyama Masaaki、Chatani Eri
- Journal Title
  
  bioRxiv
  
  Volume: -
- DOI
  10.1101/2023.09.02.556028
- Open Access
- Data Source
  KAKENHI-PROJECT-21K06503
[Journal Article] Phone2SAS: 3D scanning by smartphone aids the realization of small-angle scattering2023
- Author(s)
  Imamura Hiroshi
- Journal Title
  
  Biophysics and Physicobiology
  
  Volume: 20 Issue: 2 Pages: n/a
- DOI
  10.2142/biophysico.bppb-v20.0021
- ISSN
  2189-4779
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06503
[Journal Article] Cue to Acid-Induced Long-Range Conformational Changes in an Antibody Preceding Aggregation: The Structural Origins of the Subpeaks in Kratky Plots of Small-Angle X-ray Scattering2023
- Author(s)
  Imamura Hiroshi、Honda Shinya
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 24 Issue: 15 Pages: 12042-12042
- DOI
  10.3390/ijms241512042
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06503
[Journal Article] Molecular mechanism of the common and opposing cosolvent effects of fluorinated alcohol and urea on a coiled coil protein2023
- Author(s)
  Nakata Noa、Okamoto Ryuichi、Sumi Tomonari、Koga Kenichiro、Morita Takeshi、Imamura Hiroshi
- Journal Title
  
  Protein Science
  
  Volume: 32 Issue: 10
- DOI
  10.1002/pro.4763
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06503, KAKENHI-PROJECT-20K05431, KAKENHI-PROJECT-18KK0151, KAKENHI-PROJECT-20H02696, KAKENHI-PROJECT-23K23156
[Journal Article] Expression and characterization of C-terminal truncated mutants of γ-glutamyltranspeptidase II (PaGGTII) from Pseudomonas aeruginosa PAO12023
- Author(s)
  Wang Xinjia、Hatta Seiji、Matsui Daisuke、Imamura Hiroshi、Wakayama Mamoru
- Journal Title
  
  Protein Expression and Purification
  
  Volume: 210 Pages: 106321-106321
- DOI
  10.1016/j.pep.2023.106321
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K06503, KAKENHI-PROJECT-22K05395
[Journal Article] Getting Smaller by Denaturation: Acid-Induced Compaction of Antibodies2023
- Author(s)
  Imamura Hiroshi、Ooishi Ayako、Honda Shinya
- Journal Title
  
  The Journal of Physical Chemistry Letters
  
  Volume: 14 Issue: 16 Pages: 3898-3906
- DOI
  10.1021/acs.jpclett.3c00258
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06503
[Journal Article] タンパク質は疎水効果で安定化しているのか？2023
- Author(s)
  墨智成、今村比呂志
- Journal Title
  
  月刊「細胞」
  
  Volume: 55 Pages: 104-107
- Data Source
  KAKENHI-PROJECT-21K06503
[Journal Article] Modification of liposomes composed of a cationic lipid TMAG and an anionic lipid DSPG with a PEGylated lipid based on the investigation of lipid structures2023
- Author(s)
  Hohokabe Miyuki、Higashi Kenjirou、Yamada Yurina、Fujimoto Taiki、Tokumoto Taisei、Imamura Hiroshi、Morita Takeshi、Ueda Keisuke、Limwikrant Waree、Moribe Kunikazu
- Journal Title
  
  Colloids and Surfaces A: Physicochemical and Engineering Aspects
  
  Volume: 661 Pages: 130891-130891
- DOI
  10.1016/j.colsurfa.2022.130891
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06503, KAKENHI-PROJECT-22K06545, KAKENHI-PROJECT-23K23156
[Journal Article] タンパク質は疎水効果で安定化しているのか2023
- Author(s)
  墨智成、今村比呂志
- Journal Title
  
  アグリバイオ (月刊「細胞」 vol. 55, 104の同記事の紹介・転載)
  
  Volume: 7 Pages: 372-377
- Data Source
  KAKENHI-PROJECT-21K06503
[Journal Article] Improvement of Protein Solubility in Macromolecular Crowding during Myoglobin Evolution2022
- Author(s)
  Isogai Yasuhiro、Imamura Hiroshi、Sumi Tomonari、Shirai Tsuyoshi
- Journal Title
  
  Biochemistry
  
  Volume: 61 Issue: 15 Pages: 1543-1547
- DOI
  10.1021/acs.biochem.2c00166
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K05431, KAKENHI-PROJECT-21K06503, KAKENHI-PROJECT-18KK0151, KAKENHI-PROJECT-23K21721
[Journal Article] Disaggregation of Asphaltene Aggregates in Solutions Depending upon Affinity Indices of the Hansen Solubility Parameter Using Ultrasmall-, Small-, and Wide-Angle X-ray Scattering2022
- Author(s)
  Morita Takeshi、Morimoto Masato、Shibuta Satoshi、Imamura Hiroshi、Yamamoto Hideki、Tykwinski Rik R.、Scott David E.、Stryker Jeffrey M.、Suzuki Teruo、Tanaka Ryuzo
- Journal Title
  
  Energy & Fuels
  
  Volume: 36 Issue: 17 Pages: 10043-10051
- DOI
  10.1021/acs.energyfuels.2c01668
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06503
[Journal Article] Molecular evolution of myoglobin upon land-to-sea transition of seals traced by the structure factor of small-angle X-ray scattering2022
- Author(s)
  Imamura Hiroshi、Sumi Tomonari、Shirai Tsuyoshi、Isogai Yasuhiro
- Journal Title
  
  Photon Factory Activity Report 2021
  
  Volume: 39 Pages: 62-62
- Open Access
- Data Source
  KAKENHI-PROJECT-21K06503
[Journal Article] Small-angle X-ray scattering data of a guanine-rich DNA derived from the promoter region of c-MYC gene in solution2022
- Author(s)
  Miyauchi Kohei、Imamura Hiroshi、Yamaoki Yudai、Kato Minoru
- Journal Title
  
  Data in Brief
  
  Volume: 42 Pages: 108285-108285
- DOI
  10.1016/j.dib.2022.108285
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06503
[Journal Article] Nano-Microscopy of Therapeutic Antibody Aggregates in Solution2022
- Author(s)
  Senga Yukako、Ogura Toshihiko、Imamura Hiroshi、Honda Shinya
- Journal Title
  
  Methods in Molecular Biology
  
  Volume: 2313 Pages: 219-239
- DOI
  10.1007/978-1-0716-1450-1_13
- ISBN
  9781071614495, 9781071614501
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K15105, KAKENHI-PROJECT-21K06503, KAKENHI-PROJECT-19H03363
[Journal Article] Peptide modification on the interior surface of red blood cell ghosts for construction of catalytic reactors2022
- Author(s)
  Matsumoto Honoka、Okuichi Kentaro、Imamura Hiroshi、Yasuhara Kazuma、Kato Minoru、Koshiyama Tomomi
- Journal Title
  
  Chemical Communications
  
  Volume: 58 Issue: 87 Pages: 12220-12223
- DOI
  10.1039/d2cc05013g
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K06503, KAKENHI-PROJECT-22K05133, KAKENHI-PROJECT-21K19007, KAKENHI-PUBLICLY-21H05883
[Journal Article] Getting Smaller by Denaturation: Acid-Induced Compaction of Antibodies2022
- Author(s)
  Imamura Hiroshi、Ooishi Ayako、Honda Shinya
- Journal Title
  
  bioRxiv
  
  Volume: -
- DOI
  10.1101/2022.09.19.508607
- Open Access
- Data Source
  KAKENHI-PROJECT-21K06503
[Journal Article] Effect of backbone circularization on colloidal stability: Compaction of unfolded structures improves aggregation resistance of granulocyte colony-stimulating factor2021
- Author(s)
  Shibuya Risa、Miyafusa Takamitsu、Imamura Hiroshi、Ooishi Ayako、Honda Shinya
- Journal Title
  
  International Journal of Pharmaceutics
  
  Volume: 605 Pages: 120774-120774
- DOI
  10.1016/j.ijpharm.2021.120774
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K06503, KAKENHI-PROJECT-19H03363
[Journal Article] Water Depletion Enhanced by Halogenation of Benzene2021
- Author(s)
  Shibuta Satoshi、Imamura Hiroshi、Shibuta Kota、Judai Ken
- Journal Title
  
  The Journal of Physical Chemistry B
  
  Volume: 125 Issue: 31 Pages: 8855-8861
- DOI
  10.1021/acs.jpcb.1c03187
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K06503
[Journal Article] Solution structure and aggregates of backbone-circularized granulocyte colony-stimulating factor by SAXS2021
- Author(s)
  Shibuya Risa、Miyafusa Takamitsu、Imamura Hiroshi、Ooishi Ayako、Honda Shinya
- Journal Title
  
  Photon Factory Activity Report 2020
  
  Volume: - Pages: 194-194
- Open Access
- Data Source
  KAKENHI-PROJECT-21K06503
[Journal Article] Common and unique strategies of myoglobin evolution for deep-sea adaptation of diving mammals2021
- Author(s)
  Isogai Yasuhiro, Imamura Hiroshi, Nakae Setsu, Sumi Tomonari, Takahashi Ken-ichi, Shirai Tsuyoshi
- Journal Title
  
  iScience
  
  Volume: 24 Issue: 8 Pages: 102920-102920
- DOI
  10.1016/j.isci.2021.102920
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K05431, KAKENHI-PROJECT-21K06503, KAKENHI-PROJECT-23K21721
[Journal Article] Changes in Crystal Structure and Battery Performance of MIL-101 (Fe) upon Introduction of Substituent NH<sub>2</sub>2021
- Author(s)
  Shimizu Takeshi、Murakami Ayako、Yamamura Misaki、Imamura Hiroshi、Yamagishi Hirona、Yamamoto Yusaku
- Journal Title
  
  Memoirs of the SR Center Ritsumeikan University
  
  Volume: 23 Issue: 0 Pages: 15-18
- DOI
  10.34521/srmemoirs.23.0_15
- NAID
  130008077230
- ISSN
  1345-1650, 2435-7634
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06503
[Journal Article] Water‐mediated interactions destabilize proteins2021
- Author(s)
  Sumi Tomonari, Imamura Hiroshi
- Journal Title
  
  Protein Science
  
  Volume: 30 Issue: 10 Pages: 2132-2143
- DOI
  10.1002/pro.4168
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K05431, KAKENHI-PROJECT-21K06503, KAKENHI-PROJECT-18KK0151
[Presentation] 変性して小さくなる蛋白質の発見: SEC-SAXS法による抗体の変性構造の解析2024
- Author(s)
  今村比呂志
- Organizer
  PF研究会「物質・生命研究における小角散乱法の展開：現状と展望のための討論会」
- Data Source
  KAKENHI-PROJECT-21K06503
[Presentation] Antibody can be Smaller by Denaturation2023
- Author(s)
  Imamura Hiroshi、Ooishi Ayako、Honda Shinya
- Organizer
  International Congress on Pure and Applied Chemistry (ICPAC Bali 2023)
- Invited
- Data Source
  KAKENHI-PROJECT-21K06503
[Presentation] 抗体の変性によるコンパクト化と理想的球状化2023
- Author(s)
  今村比呂志, 大石郁子, 本田真也
- Organizer
  第61回日本生物物理学会年会
- Data Source
  KAKENHI-PROJECT-21K06503
[Presentation] Water-mediated Interactions Destabilize Proteins2023
- Author(s)
  Sumi Tomonari、Imamura Hiroshi
- Organizer
  International Congress on Pure and Applied Chemistry (ICPAC Bali 2023)
- Invited
- Data Source
  KAKENHI-PROJECT-21K06503
[Presentation] 抗体の不思議な構造変化：酸性溶液中では天然構造よりも小さくコンパクトな球状構造になる2023
- Author(s)
  今村比呂志, 大石郁子, 本田真也
- Organizer
  第2回日本抗体学会
- Data Source
  KAKENHI-PROJECT-21K06503
[Presentation] Myoglobin evolution in Paleozoic era2023
- Author(s)
  Y. Isogai, A. Tsuneshige, M. Mori, M. Yoshida, H. Imamura, T. Shirai
- Organizer
  第61回日本生物物理学会年会
- Data Source
  KAKENHI-PROJECT-21K06503
[Presentation] ウシ由来インスリンのアミロイドオリゴマーおよびプロトフィブリル形成のモデリング2023
- Author(s)
  柚佳祐, 今村比呂志, 野崎拓郎, 藤井悠生, 守島健, 奥田綾, 井上倫太郎, 杉山正明, 茶谷絵理
- Organizer
  第61回日本生物物理学会年会
- Data Source
  KAKENHI-PROJECT-21K06503
[Presentation] ウシ由来インスリンのアミロイド核形成に見られるオリゴマーおよびプロトフィブリル形成機構2023
- Author(s)
  柚佳祐, 今村比呂志, 野崎拓郎, 藤井悠生, 守島健, 奥田綾, 井上倫太郎, 杉山正明, 茶谷絵理
- Organizer
  第23回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-21K06503
[Presentation] アミロイド核形成段階におけるオリゴマーおよびプロトフィブリルの形成機構2023
- Author(s)
  柚佳祐、今村比呂志、野崎拓郎、藤井悠生、守島健、奥田綾、井上倫太郎、杉山正明、茶谷絵理
- Organizer
  第14回タンパク質の異常凝集とその防御・修復機構に関する研究会
- Data Source
  KAKENHI-PROJECT-21K06503
[Presentation] バイオ医薬品タンパク質の変性と凝集問題2023
- Author(s)
  今村比呂志
- Organizer
  高分子学会高分子計算機科学研究会
- Invited
- Data Source
  KAKENHI-PROJECT-21K06503
[Presentation] 疎水性及び親水性物質水溶液に共通する欠乏構造2023
- Author(s)
  澁田諭, 今村比呂志, 澁田宏太, 十代健
- Organizer
  第17回日本分子科学討論会
- Data Source
  KAKENHI-PROJECT-21K06503
[Presentation] 抗体の分子内凝集～変性して小さくなるタンパク質の発見2023
- Author(s)
  今村比呂志, 大石郁子, 本田真也
- Organizer
  第23回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-21K06503
[Presentation] Antibody proteins can be smaller by denaturation (変性して小さくなる蛋白質)2022
- Author(s)
  Imamura Hiroshi、Ooishi Ayako、Honda Shinya
- Organizer
  第60回日本生物物理学会年会
- Data Source
  KAKENHI-PROJECT-21K06503
[Presentation] 抗体の非標準構造2022
- Author(s)
  今村比呂志、大石郁子、本田真也
- Organizer
  第1回日本抗体学会
- Data Source
  KAKENHI-PROJECT-21K06503
[Presentation] 変性剤によって不安定化された免疫グロブリンGのタンパク質間相互作用のラマン分光解析2022
- Author(s)
  森本莉緒、中尾俊樹、今村比呂志、加藤稔
- Organizer
  第1回日本抗体学会
- Data Source
  KAKENHI-PROJECT-21K06503
[Presentation] ミニタンパク質Trp-cageとその変異体の構造安定性に及ぼす圧力効果2022
- Author(s)
  大池裕登、中尾俊樹、今村比呂志、加藤稔
- Organizer
  第63回高圧討論会
- Data Source
  KAKENHI-PROJECT-21K06503
[Presentation] 分子動力学法による自己集合性ペプチドの配列最適化2022
- Author(s)
  佐藤宏哉、笠原浩太、今村比呂志、高橋卓也
- Organizer
  第22回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-21K06503
[Presentation] Evolution of protein solubility in macromolecular crowding2022
- Author(s)
  Isogai Yasuhiro、Imamura Hiroshi、Sumi Tomonari、Shirai Tsuyoshi
- Organizer
  第60回日本生物物理学会年会
- Data Source
  KAKENHI-PROJECT-21K06503
[Presentation] ミニタンパク質Trp-cageの圧力構造変化に関する断片ペプチドを用いたFTIR研究2022
- Author(s)
  大池裕登、中尾俊樹、今村比呂志、加藤稔
- Organizer
  第44回溶液化学シンポジウム
- Data Source
  KAKENHI-PROJECT-21K06503
[Presentation] FTIR法によるc-MYC遺伝子のG4構造-coil構造転移における温度-圧力-自由エネルギー地形図2022
- Author(s)
  宮内滉平、山置佑大、今村比呂志、中尾俊樹、加藤稔
- Organizer
  第63回高圧討論会
- Data Source
  KAKENHI-PROJECT-21K06503
[Presentation] 蛋白質の分子進化とバイオ医薬品における凝集問題2022
- Author(s)
  今村比呂志
- Organizer
  Sメンブレン第2回若手教員交流会・生体分子化学合同勉強会講演会 (群馬大学)
- Invited
- Data Source
  KAKENHI-PROJECT-21K06503
[Presentation] Sequence optimization of self-assembly peptides by using MD simulations2022
- Author(s)
  Sato Koya、Kasahara Kota、Imamura Hiroshi、Takahashi Takuya
- Organizer
  第60回日本生物物理学会年会
- Data Source
  KAKENHI-PROJECT-21K06503
[Presentation] ポリマー添加による分子量に応じたコロイド分散系の安定性2022
- Author(s)
  大坂佳弘、岡本隆一、墨智成、甲賀研一郎、今村比呂志、白井剛、磯貝泰弘
- Organizer
  第36回分子シミュレーション討論会
- Data Source
  KAKENHI-PROJECT-21K06503
[Presentation] 小角X線散乱法によるc-MYC遺伝子プロモーターのグアニン四重鎖構造とコイル構造の観測2022
- Author(s)
  宮内滉平、山置佑大、今村比呂志、加藤稔
- Organizer
  2021年度量子ビームサイエンスフェスタ
- Data Source
  KAKENHI-PROJECT-21K06503
[Presentation] Cytochrome cの圧力誘起リフォールディングにおけるクラウディング効果2021
- Author(s)
  青山実伽子、今村比呂志、加藤稔
- Organizer
  第62回高圧討論会
- Data Source
  KAKENHI-PROJECT-21K06503
[Presentation] タンパク質のポリペプチド主鎖環状化による凝集抑制効果2021
- Author(s)
  渋谷理紗、宮房孝光、今村比呂志、大石郁子、本田真也
- Organizer
  産業技術総合研究所LS-BT合同研究発表会
- Data Source
  KAKENHI-PROJECT-21K06503
[Presentation] Early aggregation kinetics preceding the nucleation in distinct amyloid formation pathways between bovine and human insulin2021
- Author(s)
  柚佳祐、今村比呂志、野崎拓郎、藤井悠生、守島健、奥田綾、井上倫太郎、杉山正明、茶谷絵理
- Organizer
  第21回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-21K06503
[Presentation] Early aggregation kinetics upon the amyloid nucleation of bovine and human insulin2021
- Author(s)
  柚佳祐、今村比呂志、野崎拓郎、藤井悠生、守島健、奥田綾、井上倫太郎、杉山正明、茶谷絵理
- Organizer
  第59回日本生物物理学会年会
- Data Source
  KAKENHI-PROJECT-21K06503
[Presentation] アミロイド核形成に先立つインスリンの由来種に依存した初期凝集メカニズム2021
- Author(s)
  柚佳祐、今村比呂志、野崎拓郎、藤井悠生、守島健、奥田綾、井上倫太郎、杉山正明、富永圭介、茶谷絵理
- Organizer
  第94回日本生化学大会
- Data Source
  KAKENHI-PROJECT-21K06503
[Presentation] FTIR study of pressure-induced denaturation of the guanine quadruplex of the c-MYC gene2021
- Author(s)
  宮内滉平、山置佑大、今村比呂志、加藤稔
- Organizer
  第59回日本生物物理学会年会
- Data Source
  KAKENHI-PROJECT-21K06503
[Presentation] インスリンの由来種に依存したアミロイド核形成に先立つ初期凝集メカニズム2021
- Author(s)
  柚佳祐、今村比呂志、野崎拓郎、藤井悠生、守島健、奥田綾、井上倫太郎、杉山正明、茶谷絵理
- Organizer
  神戸大学研究基盤センター若手フロンティア研究会
- Data Source
  KAKENHI-PROJECT-21K06503
[Presentation] FTIR法によるミニタンパク質Trp-cageの立体構造に及ぼす温度・圧力効果2021
- Author(s)
  大池裕登、今村比呂志、加藤稔
- Organizer
  第62回高圧討論会
- Data Source
  KAKENHI-PROJECT-21K06503
[Presentation] ミニタンパク質Trp-cageの温度・圧力に対する構造安定性に関するFTIR研究2021
- Author(s)
  大池裕登、今村比呂志、加藤稔
- Organizer
  第43回溶液化学シンポジウム
- Data Source
  KAKENHI-PROJECT-21K06503
[Presentation] α-Chymotrypsinogen Aの圧力・温度軸変性自由エネルギー地形に関するFTIR/蛍光分光研究2021
- Author(s)
  矢嶋剛士、森下司、今村比呂志、加藤稔
- Organizer
  第62回高圧討論会
- Data Source
  KAKENHI-PROJECT-21K06503
[Presentation] 蛋白質天然変性領域における電荷分布が液-液相分離現象に及ぼす影響に関する理論的検討2021
- Author(s)
  笠原浩太、寺澤裕樹、沖川純也、今村比呂志、肥後順一、加藤稔、高橋卓也
- Organizer
  第21回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-21K06503
[Presentation] c-MYC遺伝子のグアニン四重鎖構造の安定性に及ぼす圧力効果のFTIR研究2021
- Author(s)
  宮内滉平、山置佑大、今村比呂志、加藤稔
- Organizer
  第62回高圧討論会
- Data Source
  KAKENHI-PROJECT-21K06503
[Presentation] SEC-SAXS法による溶液中の抗体変性構造の分離観測2021
- Author(s)
  今村比呂志、中原大貴、金子真実、加藤稔
- Organizer
  第21回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-21K06503

1. 森田剛 (80332633)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 墨智成 (40345955)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
3. 東顕二郎 (40451760)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 千賀由佳子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

IMAMURA Hiroshi 今村 比呂志

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医薬品抗体の変性構造の解明Principal Investigator

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Study on the origin of sustained drug releasability of polymeric nanomicelles based on clarifying the interaction potential surface

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Studies for early prediction of physical degradation of therapeutic proteinsPrincipal Investigator

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[Book] タンパク質の構造解析手法とIn silicoスクリーニングへの応用事例2023

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[Book] 品質評価のカギをにぎる バイオ医薬品の分析法 (津本、石井、内山、本田編)2022

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[Journal Article] A student experiment to realize protein charge via ion-exchange chromatography of lysozyme and Nakamura effect2024

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[Journal Article] Mechanistic Modeling of Amyloid Oligomer and Protofibril Formation in Bovine Insulin2024

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[Journal Article] Energy Transfer on Cytoskeleton of Red Blood Cell Ghosts and their Efficiency Control by KCl Concentration‐induced Cell Shrinkage2024

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[Journal Article] Mechanistic modeling of amyloid oligomer and protofibril formation2023

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[Journal Article] Phone2SAS: 3D scanning by smartphone aids the realization of small-angle scattering2023

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[Journal Article] Cue to Acid-Induced Long-Range Conformational Changes in an Antibody Preceding Aggregation: The Structural Origins of the Subpeaks in Kratky Plots of Small-Angle X-ray Scattering2023

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[Journal Article] Molecular mechanism of the common and opposing cosolvent effects of fluorinated alcohol and urea on a coiled coil protein2023

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[Journal Article] Expression and characterization of C-terminal truncated mutants of γ-glutamyltranspeptidase II (PaGGTII) from Pseudomonas aeruginosa PAO12023

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[Journal Article] Getting Smaller by Denaturation: Acid-Induced Compaction of Antibodies2023

IMAMURA Hiroshi 今村比呂志

[Book] 品質評価のカギをにぎる　バイオ医薬品の分析法 (津本、石井、内山、本田編)2022