HARA YOSHINOBU 原芳伸

… Alternative Names

Hara Yoshinobu 原芳伸

HARA Yoshinobu 原芳信

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Researcher Number	40558467
Other IDs	https://orcid.org/0000-0001-6339-5116
Affiliation (Current)	2025: 北里大学, 医学部, 講師
Affiliation (based on the past Project Information) *help	2020 – 2023: 北里大学, 医学部, 講師 2016: 北里大学, 医学部, 助教 2013: 北里大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 46020:Anatomy and histopathology of nervous system-related Except Principal Investigator Neurophysiology / General neuroscience / Neurochemistry/Neuropharmacology / Nerve anatomy/Neuropathology
Keywords	Principal Investigator リーリンシグナル / サイトへジン２ / Arf6 / 脳層形成 / 細胞内小胞輸送 / 神経細胞移動 / FRMD4A / サイトへジン2 / ApoER2 / リーリン / N-カドヘリン / 低分子量Gタンパク質 … More Except Principal Investigator … More 神経可塑性 / アクアポリン / 羊水過多 / 腎臓欠失 / 不正咬合 / 歯数過剰 / 合指多指症 / シナプス / 腎臓欠損 / リン酸化 / ノックアウトマウス / 樹状突起 / グリシン / GABA / 細胞骨格 / 低分子量G蛋白質 / 低分子量GTP結合蛋白質 / シナプス可塑性 / 足場タンパク質 / シナプス後肥厚部 / 低分子量GTP結合タンパク質 / 抑制性シナプス Less

移動神経細胞におけるサイトへジン2-Arf6小胞輸送経路活性化制御機構の解明Principal Investigator
- Principal Investigator
  
  原芳伸
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 46020:Anatomy and histopathology of nervous system-related
- Research Institution
  Kitasato University
Functional analysis of Cytohesin2-Arf6 mediated vesicular transport pathway in neuronal migrationPrincipal Investigator
- Principal Investigator
  
  Hara Yoshinobu
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 46020:Anatomy and histopathology of nervous system-related
- Research Institution
  Kitasato University
Participation of LRP4 receptor which is indispensable to neuromuscular junctions in central nervous system
- Principal Investigator
  
  TANAHASHI Hiroshi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurophysiology / General neuroscience
- Research Institution
  Shinshu University
Participation of LRP4 postsynaptic density protein in higher nerve function
- Principal Investigator
  
  TANAHASHI Hiroshi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Shinshu University
Functional analysis of the BRAG3-Arf6 pathway in the inhibitory synapse
- Principal Investigator
  
  SAKAGAMI Hiroyuki
- Project Period (FY)
  2010 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Kitasato University

All 2024 2023 2022 2021 2016 2014 2013 2012 2011 2010 Other

All Journal Article Presentation

[Journal Article] ADP Ribosylation Factor 4 (Arf4) Regulates Radial Migration through N-Cadherin Trafficking during Cerebral Cortical Development2023
- Author(s)
  Hara Yoshinobu、Katsuyama Takehiko、Fukaya Masahiro、Sugawara Takeyuki、Shiroshima Tomoko、Sadakata Tetsushi、Osumi Noriko、Sakagami Hiroyuki
- Journal Title
  
  eneuro
  
  Volume: 10 Issue: 11 Pages: 0125-23
- DOI
  10.1523/eneuro.0125-23.2023
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K05994, KAKENHI-PROJECT-22K19322
[Journal Article] Cytohesin-2 mediates group I metabotropic glutamate receptor-dependent mechanical allodynia through the activation of ADP ribosylation factor 6 in the spinal cord.2021
- Author(s)
  Ito A, Fukaya M, Sugawara T, Hara Y, Okamoto H, Yamauchi J and Sakagami H.
- Journal Title
  
  Neurobiology of Disease
  
  Volume: 159 Pages: 1-19
- DOI
  10.1016/j.nbd.2021.105466
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K22962, KAKENHI-PROJECT-20K06861, KAKENHI-PROJECT-20K06897
[Journal Article] Polyhydramnios in Lrp4 knockout mice with bilateral kidney agenesis: Defects in the pathways of amniotic fluid clearance.2016
- Author(s)
  Tanahashi, H.;Tian, Q.B.; Hara, Y.;Sakagami, H.;Endo, S.;Suzuki, T.
- Journal Title
  
  Sci Rep
  
  Volume: 6 Issue: 1 Pages: 20241-20241
- DOI
  10.1038/srep20241
- NAID
  120007100143
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-221S0003, KAKENHI-PUBLICLY-26115532, KAKENHI-PROJECT-15H03103, KAKENHI-PROJECT-15H04672, KAKENHI-PROJECT-26430014
[Journal Article] EFA6A, a gunanine nucleotide exchange factor for Arf6, interacts with sorting nexin-1 and regulates neurite outgrowth2014
- Author(s)
  Fukaya M, Fukushima D, Hara Y, Sakagami H
- Journal Title
  
  J. Neurochem
  
  Volume: 129 Issue: 1 Pages: 21-36
- DOI
  10.1111/jnc.12524
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300114, KAKENHI-PROJECT-25640025
[Journal Article] Endosomal localization of FIP3/Arfophilin-1 and its involvement in dendritic formation of mouse hippocampal neurons.2014
- Author(s)
  Yazaki Y, Hara Y, Tamaki H, Fukaya M, Sakagami H.
- Journal Title
  
  Brain Research
  
  Volume: 1557 Pages: 55-65
- DOI
  10.1016/j.brainres.2014.02.018
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300114, KAKENHI-PROJECT-25640025
[Journal Article] Endosomal localization of FIP3/Arfophilin-1 and its involvement in dendritic formation of mouse hippocampal neurons2014
- Author(s)
  Yazaki Y, Hara Y, Tamaki H, Fukaya M, Sakagami H
- Journal Title
  
  Brain Res
  
  Volume: 1557 Pages: 55-65
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300114
[Journal Article] Distinct synaptic localization patterns of brefeldin A-resistant guanine nucleotide exchange factors BRAG2 and BRAG3 in the mouse retina2013
- Author(s)
  Sakagami H, Katsumata O, Hara Y, Tamaki H, Watanabe M, Harvey RJ, Fukaya M
- Journal Title
  
  J. Comp. Neurol
  
  Volume: 521 Issue: 4 Pages: 860-876
- DOI
  10.1002/cne.23206
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300114, KAKENHI-PROJECT-23659101, KAKENHI-PROJECT-23700416, KAKENHI-PROJECT-24220007, KAKENHI-PROJECT-25640025
[Journal Article] Type I phosphatidylinositol 4-phosphate 5-kinase γ is required for neuronal migration in the mouse developing cerebral cortex2013
- Author(s)
  Hara Y, Fukaya M, Tamaki H, Sakagami H
- Journal Title
  
  Eur. J. Neurosci
  
  Volume: 38 Issue: 5 Pages: 2659-2671
- DOI
  10.1111/ejn.12286
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300114, KAKENHI-PROJECT-25640025
[Journal Article] Pilt is a coiled-coil domain-containing protein that localizes at the trans-Golgi complex and regulates its structure2012
- Author(s)
  Tamaki H, Sanda M, Katsumata O, Hara Y, Fukaya M, Sakagami H
- Journal Title
  
  FEBS Lett
  
  Volume: 586 Issue: 19 Pages: 3064-3070
- DOI
  10.1016/j.febslet.2012.07.051
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300114, KAKENHI-PROJECT-23659101, KAKENHI-PROJECT-23700416
[Journal Article] SynArfGEF is a guanine nucleotide exchage factor for Arf6 and localizes preferentially at post-synaptic specialization of inhibitory synapses.2011
- Author(s)
  Fukaya M, Kamata A, Hara Y, Tamaki H, Katsumata O, Ito N, Takeda S, Hata Y, Suzuki T, Watanabe M, Harvey RJ, Sakagami H.
- Journal Title
  
  Journal of Neurochemistry
  
  Volume: (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300114
[Journal Article] SynArfGEF is a guanine nucleotide exchange factor for Arf6 and localizes preferentially at post-synaptic specializations of inhibitory synapses2011
- Author(s)
  Fukaya, M.; Kamata, A.; Hara, Y., et al
- Journal Title
  
  Journal of Neurochemistry
  
  Volume: 116(6) Issue: 6 Pages: 1122-1137
- DOI
  10.1111/j.1471-4159.2010.07167.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19100005, KAKENHI-PROJECT-21500347, KAKENHI-PROJECT-22300114, KAKENHI-PROJECT-23659101
[Journal Article] Vezatin, a potential target for ADP-ribosylation factor 6, regulates the dendritic formation of hippocampal neurons2010
- Author(s)
  Sanda M, Ohara N, Kamata A, Hara Y, Tamaki H, Sukegawa J, Yanagisawa T, Fukunaga K, Kondo H, Sakagami H
- Journal Title
  
  Neurosci. Res
  
  Volume: 67(2) Issue: 2 Pages: 126-136
- DOI
  10.1016/j.neures.2010.02.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300114
[Journal Article] Vezatin, a potential target for ADP-ribosylation factor 6, regulates the dendritic formation of hippocampal neurons.2010
- Author(s)
  Sanda M, Ohara N, Kamata A, Hara Y, Tamaki H, Sukegawa J, Yanagisawa T, Fukunaga K, Kondo H, Sakagami H.
- Journal Title
  
  Neurosci.Research
  
  Volume: 67 Pages: 126-136
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300114
[Journal Article] Comprehensive behavioral analysis of calcium/calmodulin-dependent protein kinase IV knockout mice.2010
- Author(s)
  Takao K, Tanda K, Nakamura K, Kasahara J, Nakao K, Katsuki M, Nakanishi K, Yamasaki N, Toyama K, Adachi M, Umeda M, Araki T, Fukunaga K, Kondo H, Sakagami H, Miyakawa T.
- Journal Title
  
  PLoS ONE
  
  Volume: 5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300114
[Journal Article] Comprehensive behavioral analysis of calcium/calmodulin-dependent protein kinase IV knockout mice2010
- Author(s)
  Takao K, Tanda K, Nakamura K, Kasahara J, Nakao K, Katsuki M, Nakanishi K, Yamasaki N, Toyama K, Adachi M, Umeda M, Araki T, Fukunaga K, Kondo H, Sakagami H, Miyakawa T
- Journal Title
  
  PLoS ONE
  
  Volume: Vol.5, No.3 Issue: 3 Pages: e9460-e9460
- DOI
  10.1371/journal.pone.0009460
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21300121, KAKENHI-PROJECT-22300114
[Journal Article] Identification and characterization of PRG-1 as a neuronal calmodulin-binding protein.2010
- Author(s)
  Tokumitsu H, Hatano N, Tsuchiya M, Yurimoto S, Fujimoto T, Ohara N, Kobayashi R, Sakagami H.
- Journal Title
  
  Biochem Journal
  
  Volume: 43 Pages: 81-91
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300114
[Journal Article] Identification and characterization of PRG-1 as a neuronal calmodulin-binding protein2010
- Author(s)
  Tokumitsu H, Hatano N, Tsuchiya M, Yurimoto S, Fujimoto T, Ohara N, Kobayashi R, Sakagami H
- Journal Title
  
  Biochem J
  
  Volume: 43 Issue: 1 Pages: 81-91
- DOI
  10.1042/bj20100637
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300114
[Presentation] 胎児大脳皮質FRMD4A（FERM domain-containing protein 4A）の発現・局在・機能解析2024
- Author(s)
  原芳伸，吉田大我，阪上洋行
- Organizer
  第129回日本解剖学会・全国学術集会
- Data Source
  KAKENHI-PROJECT-23K05994
[Presentation] 低分子量Gタンパク質Arf4は逆行性小胞輸送を介して神経細胞移動を制御する2023
- Author(s)
  原芳伸、阪上洋行
- Organizer
  第128回日本解剖学会総会・全国学術集会
- Data Source
  KAKENHI-PROJECT-20K06897
[Presentation] 神経細胞移動における低分子量Gタンパク質Arf4およびArf5の機能的役割2022
- Author(s)
  原芳伸，阪上洋行
- Organizer
  日本解剖学会第127回全国学術集会
- Data Source
  KAKENHI-PROJECT-20K06897
[Presentation] 神経細胞移動における低分子量Gタンパク質Arf4およびArf5の機能的役割2022
- Author(s)
  原芳伸、阪上洋行
- Organizer
  第127回日本解剖学会総会・全国学術集会
- Data Source
  KAKENHI-PROJECT-20K06897
[Presentation] Arf４は逆行性輸送を介して神経細胞移動を制御する2022
- Author(s)
  原芳伸，阪上洋行
- Organizer
  日本解剖学会第110回関東支部学術集会
- Data Source
  KAKENHI-PROJECT-20K06897
[Presentation] 移動神経細胞における低分子量Gタンパク質Arf4の機能的役割2021
- Author(s)
  原芳伸，阪上洋行
- Organizer
  日本解剖学会第109回関東支部学術集会
- Data Source
  KAKENHI-PROJECT-20K06897
[Presentation] 脳層形成における低分子量GTP 結合タンパク質Arf6の機能的役割2014
- Author(s)
  原芳伸、深谷昌弘、阪上洋行
- Organizer
  第119回日本解剖学会総会・全国学術集会
- Place of Presentation
  自治医大
- Year and Date
  2014-03-29
- Data Source
  KAKENHI-PROJECT-22300114
[Presentation] Expression and functional roles of phosphatidylinositol 4-phosphate 5-kinase (PIP5K) γ in the developing cerebral cortex.2013
- Author(s)
  原　芳伸
- Organizer
  第117回日本解剖学会総会・全国学術集会
- Place of Presentation
  香川
- Data Source
  KAKENHI-PROJECT-22300114
[Presentation] Expression and functional roles of phosphatidylinositol 4-phosphate 5-kinase (PIP5K) γ in the developing cerebral cortex2012
- Author(s)
  原芳伸、阪上洋行
- Organizer
  欧州神経科学会
- Place of Presentation
  バルセロナ
- Year and Date
  2012-07-15
- Data Source
  KAKENHI-PROJECT-22300114
[Presentation] DISTINCT LOCALIZATION OF THE BRAG/IQSEC FAMILY OF GUANINE NUCLEOTIDE EXCHANGE FACTORS FOR ARF6 IN THE MOUSE RETINA2012
- Author(s)
  阪上洋行、原芳伸、深谷昌弘
- Organizer
  欧州神経科学会議
- Place of Presentation
  バルセロナ
- Year and Date
  2012-07-15
- Data Source
  KAKENHI-PROJECT-22300114
[Presentation] 成体マウス脳におけるARF6活性化因子BRAG2/IQSEC1の細胞内局在解析2012
- Author(s)
  深谷昌弘、原芳伸、阪上洋行
- Organizer
  第117回日本解剖学会総会・全国学術集会
- Place of Presentation
  山梨大学(山梨県)
- Year and Date
  2012-03-28
- Data Source
  KAKENHI-PROJECT-22300114
[Presentation] 大脳皮質層形成におけるホスファチジルイノシトール4-リン酸5キナーゼの機能解析2012
- Author(s)
  原芳伸、阪上洋行
- Organizer
  第117回日本解剖学会総会・全国学術集会
- Place of Presentation
  山梨大学(山梨県)
- Year and Date
  2012-03-26
- Data Source
  KAKENHI-PROJECT-22300114
[Presentation] Expression and functional roles of phosphatidylinositol 4-phosphate 5-kinase (PIP5K) γ in the developing cerebral cortex.2012
- Author(s)
  原　芳伸
- Organizer
  第8回欧州神経科学大会(FENS2012)
- Place of Presentation
  バルセロナ、スペイン
- Data Source
  KAKENHI-PROJECT-22300114
[Presentation] 成熟期マウス脳におけるBRAG2/GEP100の細胞内局在解析2011
- Author(s)
  深谷昌弘、原芳伸、阪上洋行
- Organizer
  第34回日本神経科学会
- Place of Presentation
  パシフィコ横浜(神奈川県)
- Year and Date
  2011-09-17
- Data Source
  KAKENHI-PROJECT-22300114
[Presentation] 大脳皮質形成におけるホスファチジルイノシトール4-リン酸5キナーゼの機能解析2011
- Author(s)
  原芳伸、西村伸彦、深谷昌弘、玉木英明、阪上洋行
- Organizer
  第99回日本解剖学関東支部学術集会
- Place of Presentation
  日本大学松戸歯学部(千葉県)
- Year and Date
  2011-10-15
- Data Source
  KAKENHI-PROJECT-22300114
[Presentation] 大脳皮質層形成におけるPIP5Kgammaの発現機能解析2011
- Author(s)
  原芳伸、西村伸彦、阪上洋行
- Organizer
  第34回日本神経科学会
- Place of Presentation
  パシフィコ横浜(神奈川県)
- Year and Date
  2011-09-15
- Data Source
  KAKENHI-PROJECT-22300114
[Presentation] 低分子量G蛋白質ARF6特異的グアニンヌクレオチド交換因子GEP100/BRAG2の神経系における発現と樹状突起形成への機能関与2010
- Author(s)
  阪上洋行、小原直樹
- Organizer
  第33回日本神経科学大会
- Place of Presentation
  神戸コンベンションセンター、神戸市、兵庫県
- Year and Date
  2010-09-02
- Data Source
  KAKENHI-PROJECT-22300114
[Presentation] 脳層形成における低分子量GTP結合タンパク質Arf6の機能的役割
- Author(s)
  原芳伸、阪上洋行
- Organizer
  第119回日本解剖学会総会・全国学術集会
- Place of Presentation
  自治医科大学
- Data Source
  KAKENHI-PROJECT-22300114
[Presentation] Phosphatidylinositol 4-phosphate kinase 5g は大脳皮質層形成において神経細胞の移動を制御する
- Author(s)
  原芳伸、深谷昌弘、阪上洋行
- Organizer
  第３６回日本神経科学大会
- Place of Presentation
  京都国際会議場
- Data Source
  KAKENHI-PROJECT-22300114

1. SAKAGAMI Hiroyuki (90261528)

# of Collaborated Projects: 3 results

# of Collaborated Products: 24 results
2. TANAHASHI Hiroshi (90236654)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. SUZUKI Tatsuo (80162965)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. TAMAKI Hideaki (30155246)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
5. TAKAO Keizo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 深谷昌弘

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 鈴木匡子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 鈴木道雄

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 宮川剛

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 遠山桂子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 伊藤諭子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

HARA YOSHINOBU 原 芳伸

Hara Yoshinobu 原 芳伸

HARA Yoshinobu 原 芳信

Research Projects

Research Products

Co-Researchers

移動神経細胞におけるサイトへジン2-Arf6小胞輸送経路活性化制御機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Functional analysis of Cytohesin2-Arf6 mediated vesicular transport pathway in neuronal migrationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Participation of LRP4 receptor which is indispensable to neuromuscular junctions in central nervous system

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Participation of LRP4 postsynaptic density protein in higher nerve function

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Functional analysis of the BRAG3-Arf6 pathway in the inhibitory synapse

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] ADP Ribosylation Factor 4 (Arf4) Regulates Radial Migration through N-Cadherin Trafficking during Cerebral Cortical Development2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cytohesin-2 mediates group I metabotropic glutamate receptor-dependent mechanical allodynia through the activation of ADP ribosylation factor 6 in the spinal cord.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Polyhydramnios in Lrp4 knockout mice with bilateral kidney agenesis: Defects in the pathways of amniotic fluid clearance.2016

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] EFA6A, a gunanine nucleotide exchange factor for Arf6, interacts with sorting nexin-1 and regulates neurite outgrowth2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Endosomal localization of FIP3/Arfophilin-1 and its involvement in dendritic formation of mouse hippocampal neurons.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Endosomal localization of FIP3/Arfophilin-1 and its involvement in dendritic formation of mouse hippocampal neurons2014

Author(s)

Journal Title

Data Source

[Journal Article] Distinct synaptic localization patterns of brefeldin A-resistant guanine nucleotide exchange factors BRAG2 and BRAG3 in the mouse retina2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Type I phosphatidylinositol 4-phosphate 5-kinase γ is required for neuronal migration in the mouse developing cerebral cortex2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Pilt is a coiled-coil domain-containing protein that localizes at the trans-Golgi complex and regulates its structure2012

Author(s)

Journal Title

DOI

HARA YOSHINOBU 原芳伸

Hara Yoshinobu 原芳伸

HARA Yoshinobu 原芳信