iwama eiji 岩間映二

… Alternative Names

Iwama Eiji 岩間映二

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Researcher Number	40567343
Other IDs
Affiliation (Current)	2025: 九州大学, 医学研究院, 准教授
Affiliation (based on the past Project Information) *help	2024: 九州大学, 医学研究院, 准教授 2023: 九州大学, 大学院医学研究院呼吸器内科学分野, 准教授 2021 – 2023: 九州大学, 大学病院, 講師 2019 – 2020: 九州大学, 大学病院, 助教 2016 – 2018: 九州大学, 医学研究院, 助教 2015 – 2016: 九州大学, 医学(系)研究科(研究院), 助教
Review Section/Research Field	Principal Investigator Basic Section 50010:Tumor biology-related / Basic Section 53030:Respiratory medicine-related / Tumor diagnostics Except Principal Investigator Tumor therapeutics
Keywords	Principal Investigator 抗体薬物複合体 / HER2 / 非小細胞肺癌 / ダイマー / EGFR遺伝子変異 / EGFR / 二量体形成 / エンドサイトーシス / EGFR遺伝子変異陽性肺癌 / 耐性克服 … More / ダイマー形成 / 遺伝子変異 / 分子標的治療薬 / HER2遺伝子変異 / リキッドバイオプシー / 細胞・組織 / 遺伝子 / 癌 / 活性型遺伝子変異 / C797S / T790M / 第三世代EGFRチロシンキナーゼ阻害剤 / Digital PCR … More Except Principal Investigator 癌幹細胞 / EGFR遺伝子 / 肺癌 / CD44 / ROS / EGFR遺伝子変異 / レドックスバランス / 抗癌剤感受性 / グルタチオン / 非小細胞肺癌 / 上皮成長因子受容体(EGFR) / 活性酸素 / CD44バリアント(CD44v) Less

非小細胞肺癌に対する抗HER2抗体薬物複合体の作用機序解明と治療への応用Principal Investigator
- Principal Investigator
  
  岩間映二
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Kyushu University
Studies on the mechanism of action of antibody-drug conjugates in EGFR mutation-positive lung cancerPrincipal Investigator
- Principal Investigator
  
  Iwama Eiji
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Kyushu University
A study of molecular biology and liquid biopsy for non-small cell lung cancer positive for HER2 mutationsPrincipal Investigator
- Principal Investigator
  
  Iwama Eiji
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Kyushu University
第三世代EGFRチロシンキナーゼ阻害剤耐性遺伝子変異の検出と克服Principal Investigator
- Principal Investigator
  
  岩間映二
- Project Period (FY)
  2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor diagnostics
- Research Institution
  Kyushu University
Functional analysis of cancer stem cell marker CD44v in EGFR-mutated non-small cell lung cancer
- Principal Investigator
  
  Okamoto Isamu
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor therapeutics
- Research Institution
  Kyushu University

All 2023 2022 2020 2019 2018 2017 2016

All Journal Article Presentation

[Journal Article] Mutant forms of EGFR promote HER2 trafficking through efficient formation of HER2-EGFR heterodimers2023
- Author(s)
  Tsutsumi Hirono、Iwama Eiji、Ibusuki Ritsu、Shimauchi Atsushi、Ota Keiichi、Yoneshima Yasuto、Inoue Hiroyuki、Tanaka Kentaro、Nakanishi Yoichi、Okamoto Isamu
- Journal Title
  
  Lung Cancer
  
  Volume: 175 Pages: 101-111
- DOI
  10.1016/j.lungcan.2022.11.018
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K07100
[Journal Article] Longitudinal monitoring of somatic genetic alterations in circulating cell-free DNA during treatment with epidermal growth factor receptor-tyrosine kinase inhibitors.2020
- Author(s)
  Iwama E, Sakai K, Hidaka N, Inoue K, Fujii A, Nakagaki N, Ota K, Toyozawa R, Azuma K, Nakatomi K, Harada T, Hisasue J, Sakata S, Shimose T, Kishimoto J, Nakanishi Y, Nishio K, Okamoto I.
- Journal Title
  
  Cancer
  
  Volume: 126(1) Issue: 1 Pages: 219-227
- DOI
  10.1002/cncr.32481
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K15214
[Journal Article] Genetic Profiling of Non‐Small Cell Lung Cancer at Development of Resistance to First‐ or Second‐Generation EGFR‐TKIs by CAPP‐Seq Analysis of Circulating Tumor DNA2019
- Author(s)
  Otsubo Kohei、Sakai Kazuko、Takeshita Masafumi、Harada Daijiro、Azuma Koichi、Ota Keiichi、Akamatsu Hiroaki、Goto Koichi、Horiike Atsushi、Kurata Takayasu、Nakagaki Noriaki、Nosaki Kaname、Iwama Eiji、Nakanishi Yoichi、Nishio Kazuto、Okamoto Isamu
- Journal Title
  
  The Oncologist
  
  Volume: 24 Issue: 8 Pages: 1022-1026
- DOI
  10.1634/theoncologist.2019-0101
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07271, KAKENHI-PROJECT-18K15214
[Journal Article] Heregulin expression and its clinical implication for patients with EGFR-mutant non-small cell lung cancer treated with EGFR-tyrosine kinase inhibitors.2019
- Author(s)
  Yonesaka K, Iwama E, Hayashi H, Suzuki S, Kato R, Watanabe S, Takahama T, Tanizaki J, Tanaka K, Takeda M, Sakai K, Azuma K, Chiba Y, Atagi S, Nishio K, Okamoto I, Nakagawa K.
- Journal Title
  
  Ｓｃｉｅｎｔｉｆｉｃ rｅｐｏｒｔｓ
  
  Volume: 9(1) Issue: 1 Pages: 19501-19501
- DOI
  10.1038/s41598-019-55939-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K15214
[Journal Article] Exploration of resistance mechanisms for epidermal growth factor receptor-tyrosine kinase inhibitors based on plasma analysis by digital polymerase chain reaction and next-generation sequencing.2018
- Author(s)
  Iwama E, Sakai K, Azuma K, Harada D, Nosaki K, Hotta K, Nishio M, Kurata T, Fukuhara T, Akamatsu H, Goto K, Shimose T, Kishimoto J, Nakanishi Y, Nishio K, Okamoto I.
- Journal Title
  
  Cancer Sci
  
  Volume: 109 Issue: 12 Pages: 3921-3933
- DOI
  10.1111/cas.13820
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07271, KAKENHI-PROJECT-18K15214, KAKENHI-PLANNED-17H06404
[Journal Article] CD44 variant dependent regulation of redox balance in EGFR mutation-positive non-small cell lung cancer: A target for treatment2017
- Author(s)
  Kawano Y., Iwama E., Tsuchihashi K., Shibahara D., Harada T., Tanaka K., Nagano O., Saya H., Nakanishi Y. & Okamoto I.
- Journal Title
  
  Lung Cancer
  
  Volume: 113 Pages: 72-78
- DOI
  10.1016/j.lungcan.2017.09.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K06874
[Presentation] Mutant EGFR affects HER2 dynamics, providing a rationale for HER2-targeted therapy for EGFR-mutated lung cancer2022
- Author(s)
  Hirono Tsutsumi, Eiji Iwama, Ritsu Ibusuki, Yasuto Yoneshima, Kentaro Tanaka, Isamu Okamoto
- Organizer
  第81回日本癌学会学術集会
- Data Source
  KAKENHI-PROJECT-21K07100
[Presentation] EGFR遺伝子変異陽性肺癌治療における大規模前向きリキッドバイオプシー研究2019
- Author(s)
  岩間映二
- Organizer
  第116 回日本内科学会講演会
- Data Source
  KAKENHI-PROJECT-18K15214
[Presentation] EGFR遺伝子変異陽性非小細胞肺癌における、CD44v、EGFRシグナルを介した活性酸素制御2016
- Author(s)
  河野裕子、岡本勇、岩間映二、原田大志、土橋賢司、永野修、佐谷秀行、中西洋一
- Organizer
  がん分子標的治療学会
- Place of Presentation
  大分県別府
- Year and Date
  2016-05-30
- Data Source
  KAKENHI-PROJECT-15K06874
[Presentation] EGFR遺伝子変異陽性非小細胞肺癌における、CD44ｖ、EGFRシグナルを介した活性酸素制御2016
- Author(s)
  河野裕子、岡本勇、岩間映二、原田大志、土橋賢司、永野修、佐谷秀行、中西洋一
- Organizer
  がん分子標的治療学会
- Place of Presentation
  大分県別府
- Year and Date
  2016-05-30
- Data Source
  KAKENHI-PROJECT-15K06874

1. Okamoto Isamu (10411597)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
2. 原田大志 (10380619)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
3. 中西洋一 (20172356)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
4. 田中謙太郎 (00536849)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. KOU Yasuhiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 赤松弘朗

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

iwama eiji 岩間 映二

Iwama Eiji 岩間 映二

Research Projects

Research Products

Co-Researchers

非小細胞肺癌に対する抗HER2抗体薬物複合体の作用機序解明と治療への応用Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Studies on the mechanism of action of antibody-drug conjugates in EGFR mutation-positive lung cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

A study of molecular biology and liquid biopsy for non-small cell lung cancer positive for HER2 mutationsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

第三世代EGFRチロシンキナーゼ阻害剤耐性遺伝子変異の検出と克服Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Functional analysis of cancer stem cell marker CD44v in EGFR-mutated non-small cell lung cancer

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Mutant forms of EGFR promote HER2 trafficking through efficient formation of HER2-EGFR heterodimers2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Longitudinal monitoring of somatic genetic alterations in circulating cell-free DNA during treatment with epidermal growth factor receptor-tyrosine kinase inhibitors.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Genetic Profiling of Non‐Small Cell Lung Cancer at Development of Resistance to First‐ or Second‐Generation EGFR‐TKIs by CAPP‐Seq Analysis of Circulating Tumor DNA2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Heregulin expression and its clinical implication for patients with EGFR-mutant non-small cell lung cancer treated with EGFR-tyrosine kinase inhibitors.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Exploration of resistance mechanisms for epidermal growth factor receptor-tyrosine kinase inhibitors based on plasma analysis by digital polymerase chain reaction and next-generation sequencing.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] CD44 variant dependent regulation of redox balance in EGFR mutation-positive non-small cell lung cancer: A target for treatment2017

Author(s)

Journal Title

DOI

Data Source

[Presentation] Mutant EGFR affects HER2 dynamics, providing a rationale for HER2-targeted therapy for EGFR-mutated lung cancer2022

Author(s)

Organizer

Data Source

[Presentation] EGFR遺伝子変異陽性肺癌治療における大規模前向きリキッドバイオプシー研究2019

Author(s)

Organizer

Data Source

[Presentation] EGFR遺伝子変異陽性非小細胞肺癌における、CD44v、EGFRシグナルを介した活性酸素制御2016

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] EGFR遺伝子変異陽性非小細胞肺癌における、CD44ｖ、EGFRシグナルを介した活性酸素制御2016

iwama eiji 岩間映二

Iwama Eiji 岩間映二