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HIGURASHI Norimichi  日暮 憲道

ORCIDConnect your ORCID iD *help
Researcher Number 40568820
Other IDs
Affiliation (Current) 2025: 東京慈恵会医科大学, 医学部, 講師
Affiliation (based on the past Project Information) *help 2017 – 2023: 東京慈恵会医科大学, 医学部, 講師
2013 – 2016: 東京慈恵会医科大学, 医学部, 助教
2010 – 2012: 福岡大学, 医学部, 助手
Review Section/Research Field
Principal Investigator
Pediatrics / Basic Section 52050:Embryonic medicine and pediatrics-related
Keywords
Principal Investigator
遺伝子 / てんかん / 疾患モデルラット / 発達性てんかん性脳症 / モデルラット / 病態 / iPS細胞 / 女性 / 行動解析 / 機能的磁気共鳴画像法 … More / 磁気共鳴画像法 / 移植・再生医療 / 脳波 / 難治てんかん / 小動物MRI / ガンマアミノ酪酸 / 脳神経活動 / てんかん発作 / 磁気共鳴画像 / SCN1A / 創薬 / MRI / 細胞治療 / 脳血液関門 / 小児 / 接着分子 / 血液脳関門 / 免疫 / 疾患モデル動物 / 精神遅滞 Less
  • Research Projects

    (5 results)
  • Research Products

    (111 results)
  • Co-Researchers

    (13 People)
  •  磁気共鳴画像法を活用したドラベ症候群ラットの年齢依存性脳機能病態の解明Principal Investigator

    • Principal Investigator
      日暮 憲道
    • Project Period (FY)
      2021 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52050:Embryonic medicine and pediatrics-related
    • Research Institution
      Jikei University School of Medicine
  •  Research on regional brain activity for future development of cell-based therapy in Dravet syndromePrincipal Investigator

    • Principal Investigator
      HIGURASHI NORIMICHI
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52050:Embryonic medicine and pediatrics-related
    • Research Institution
      Jikei University School of Medicine
  •  Research on Dravet syndrome by using patient-derived iPS cells and a rat modelPrincipal Investigator

    • Principal Investigator
      HIGURASHI NORIMICHI
    • Project Period (FY)
      2014 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Jikei University School of Medicine
  •  Research on PCDH19 female epilepsy by using patient-derived iPS cells and a rat modelPrincipal Investigator

    • Principal Investigator
      HIGURASHI Norimichi
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Pediatrics
    • Research Institution
      Jikei University School of Medicine
      Fukuoka University
  •  Genetic and Clinical Investigation of Japanese Females with PCDH19 AbnormalityPrincipal Investigator

    • Principal Investigator
      HIGURASHI Norimichi
    • Project Period (FY)
      2010 – 2011
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Pediatrics
    • Research Institution
      Fukuoka University

All 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 Other

All Journal Article Presentation Book

  • [Book] 小児科診療増刊号 エキスパートの経験に学ぶ 小児科Decision Making2021

    • Author(s)
      日暮憲道
    • Total Pages
      493
    • Publisher
      診断と治療社
    • Data Source
      KAKENHI-PROJECT-18K07802
  • [Book] てんかん専門医ハンドブック改訂第2版2020

    • Author(s)
      日暮憲道
    • Total Pages
      433
    • Publisher
      診断と治療社
    • Data Source
      KAKENHI-PROJECT-18K07802
  • [Book] クリニシアン2020

    • Author(s)
      日暮憲道
    • Total Pages
      155
    • Publisher
      エーザイ株式会社
    • Data Source
      KAKENHI-PROJECT-18K07802
  • [Book] 日本医師会雑誌 第148巻特別号 指定難病ぺディア(PCDH19関連症候群)2019

    • Author(s)
      日暮憲道
    • Total Pages
      366
    • Publisher
      日本医師会
    • Data Source
      KAKENHI-PROJECT-18K07802
  • [Book] 月間 難病と在宅ケア(小児てんかんの発作の種類を読み解く)2019

    • Author(s)
      日暮憲道
    • Total Pages
      64
    • Publisher
      日本プランニングセンター
    • Data Source
      KAKENHI-PROJECT-18K07802
  • [Book] ぺランパネルによるてんかん治療のストラテジー(児童・小児のてんかんの特徴と治療)2019

    • Author(s)
      日暮憲道
    • Total Pages
      89
    • Publisher
      先端医学社
    • Data Source
      KAKENHI-PROJECT-18K07802
  • [Book] 稀少てんかんの診療指標2017

    • Author(s)
      日暮憲道
    • Total Pages
      276
    • Publisher
      診断と治療社
    • Data Source
      KAKENHI-PROJECT-26461552
  • [Book] 新薬と臨床2017

    • Author(s)
      日暮憲道, 廣瀬伸一
    • Total Pages
      100
    • Publisher
      医薬情報研究所
    • Data Source
      KAKENHI-PROJECT-26461552
  • [Book] 小児科診療増刊号 小児の症候群2016

    • Author(s)
      日暮憲道
    • Total Pages
      416
    • Publisher
      診断と治療社
    • Data Source
      KAKENHI-PROJECT-26461552
  • [Book] 医学のあゆみ てんかんの遺伝子診断2015

    • Author(s)
      日暮憲道
    • Total Pages
      70
    • Publisher
      医歯薬出版
    • Data Source
      KAKENHI-PROJECT-26461552
  • [Book] 遺伝子医学MOOK 27号 iPS細胞を用いた難病研究-臨床病態解明と創薬に向けた研究の最新知見2015

    • Author(s)
      4.日暮憲道, 廣瀬伸一
    • Total Pages
      228
    • Publisher
      メディカル ドゥ
    • Data Source
      KAKENHI-PROJECT-24791095
  • [Book] 遺伝子医学MOOK 27号 iPS細胞を用いた難病研究-臨床病態解明と創薬に向けた研究の最新知見2015

    • Author(s)
      日暮憲道, 廣瀬伸一
    • Total Pages
      228
    • Publisher
      メディカル ドゥ
    • Data Source
      KAKENHI-PROJECT-26461552
  • [Book] 日本臨牀別冊 神経症候群VI2014

    • Author(s)
      日暮憲道, 廣瀬伸一
    • Total Pages
      1000
    • Publisher
      日本臨牀社
    • Data Source
      KAKENHI-PROJECT-24791095
  • [Book] 症例から学ぶ 戦略的てんかん診断・治療2014

    • Author(s)
      日暮憲道,井原由紀子,廣瀬伸一
    • Total Pages
      242
    • Publisher
      南山堂
    • Data Source
      KAKENHI-PROJECT-26461552
  • [Book] 症例から学ぶ 戦略的てんかん診断・治療2014

    • Author(s)
      日暮憲道,井原由紀子,廣瀬伸一
    • Total Pages
      242
    • Publisher
      南山堂
    • Data Source
      KAKENHI-PROJECT-24791095
  • [Book] 子どものけいれん・てんかん 見つけ方・見分け方から治療戦略へ2013

    • Author(s)
      日暮憲道、他
    • Total Pages
      268
    • Publisher
      中山書店
    • Data Source
      KAKENHI-PROJECT-24791095
  • [Book] 稀少難治てんかん診療マニュアル―疾患の特徴と診断のポイント2013

    • Author(s)
      日暮憲道、他
    • Total Pages
      170
    • Publisher
      診断と治療社
    • Data Source
      KAKENHI-PROJECT-24791095
  • [Book] 臨床てんかん学

    • Author(s)
      日暮憲道, 廣瀬伸一
    • Total Pages
      688
    • Publisher
      医学書院
    • Data Source
      KAKENHI-PROJECT-26461552
  • [Journal Article] Developmental changes in brain activity of heterozygous Scn1a knockout rats2023

    • Author(s)
      Tahara Mayu、Higurashi Norimichi、Hata Junichi、Nishikawa Masako、Ito Ken、Hirose Shinichi、Kaneko Takehito、Mashimo Tomoji、Sakuma Tetsushi、Yamamoto Takashi、Okano Hirotaka James
    • Journal Title

      Frontiers in Neurology

      Volume: 14 Pages: 1125089-1125089

    • DOI

      10.3389/fneur.2023.1125089

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K06137, KAKENHI-PROJECT-21K07780, KAKENHI-PROJECT-18KK0307
  • [Journal Article] MERS2型に罹患したX連鎖Charcot-Marie-Tooth病の兄弟例2022

    • Author(s)
      伊藤研、日暮憲道、古河賢太郎、橋口昭大、高嶋博、菊池健二郎
    • Journal Title

      脳と発達

      Volume: 54 Pages: 56-60

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K07780
  • [Journal Article] Genetics and gene therapy in Dravet syndrome2021

    • Author(s)
      Higurashi Norimichi、Broccoli Vania、Hirose Shinichi
    • Journal Title

      Epilepsy & Behavior

      Volume: --- Pages: 108043-108043

    • DOI

      10.1016/j.yebeh.2021.108043

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20H03651, KAKENHI-PROJECT-21K07780
  • [Journal Article] GFAP variant p.Tyr366Cys demonstrated widespread brain cavitation in neonatal Alexander disease2021

    • Author(s)
      Takeuchi H, Higurashi N, Kawame H, Kaname T, Yanagi K, Nonaka Y, Hirotsu T, Matsushima S, Shimizu T, Gomi T, Fukasawa N
    • Journal Title

      Radiol Case Rep

      Volume: 17 Issue: 3 Pages: 771-774

    • DOI

      10.1016/j.radcr.2021.11.066

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K09916, KAKENHI-PROJECT-21K07780
  • [Journal Article] Body temperature predicts recurrent febrile seizures in the same febrile illness2021

    • Author(s)
      Kubota J, Norimichi Higurashi N, Hirano D, Okabe S, Yamauchi K, Kimura R, Numata N, Suzuki T, Kakegawa D
    • Journal Title

      Brain Dev

      Volume: -

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K07802
  • [Journal Article] Impaired neuronal activity and differential gene expression in STXBP1 encephalopathy patient iPSC-derived GABAergic neurons2021

    • Author(s)
      Ichise Eisuke、Chiyonobu Tomohiro、Ishikawa Mitsuru、Tanaka Yasuyoshi、Shibata Mami、Tozawa Takenori、Taura Yoshihiro、Yamashita Satoshi、Yoshida Michiko、Morimoto Masafumi、Higurashi Norimichi、Yamamoto Toshiyuki、Okano Hideyuki、Hirose Shinichi
    • Journal Title

      Human Molecular Genetics

      Volume: - Issue: 14 Pages: 1337-1348

    • DOI

      10.1093/hmg/ddab113

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K17347, KAKENHI-PROJECT-20K16898, KAKENHI-PROJECT-21K07780, KAKENHI-PROJECT-21K07855, KAKENHI-PROJECT-21K07873
  • [Journal Article] Predictors of recurrent febrile seizures during the same febrile illness in children with febrile seizures.2020

    • Author(s)
      Kubota J, Higurashi N, Hirano D, Isono H, Numata H, Suzuki T, Kakegawa D, Ito A, Yoshihashi M, Ito T, Hamano SI.
    • Journal Title

      J Neurol Sci

      Volume: 411 Pages: 116682-116682

    • DOI

      10.1016/j.jns.2020.116682

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K07802
  • [Journal Article] Application of induced pluripotent stem cells in epilepsy2020

    • Author(s)
      Hirose Shinichi、Tanaka Yasuyoshi、Shibata Mami、Kimura Yuichi、Ishikawa Mitsuru、Higurashi Norimichi、Yamamoto Toshiyuki、Ichise Eisuke、Chiyonobu Tomohiro、Ishii Atsushi
    • Journal Title

      Molecular and Cellular Neuroscience

      Volume: 108 Pages: 103535-103535

    • DOI

      10.1016/j.mcn.2020.103535

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K17347, KAKENHI-PROJECT-19K17381, KAKENHI-PROJECT-20H03651, KAKENHI-PROJECT-18K07802, KAKENHI-PROJECT-18K07803, KAKENHI-PROJECT-18K15735
  • [Journal Article] Tatton-Brown-Rahman syndrome with a novel DNMT3A mutation presented severe intellectual disability and autism spectrum disorder2020

    • Author(s)
      Yokoi T, Enomoto Y, Naruto T, Kurosawa K, Higurashi N
    • Journal Title

      Hum Genome Var

      Volume: 2020;7 Issue: 1

    • DOI

      10.1038/s41439-020-0102-6

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K07802
  • [Journal Article] Establishment of human induced pluripotent stem cells derived from skin cells of a patient with Dravet syndrome.2020

    • Author(s)
      Kimura Y, Tanaka Y, Shirasu N, Yasunaga S, Higurashi N, Hirose S.
    • Journal Title

      Stem Cell Res.

      Volume: 47 Pages: 101857-101857

    • DOI

      10.1016/j.scr.2020.101857

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K08828, KAKENHI-PROJECT-20H03651, KAKENHI-PROJECT-18K07802, KAKENHI-PROJECT-18K15735
  • [Journal Article] Classification as autonomic versus sensory seizures.2019

    • Author(s)
      Fisher RS, Cross H, D'Souza C, French JA, Haut S, Higurashi N, Hirsch E, Jansen FE, Peltola J, Moshe SL, Perucca E, Lagae L, Roulet-Perez E, Schulze-Bonhage A, Scheffer IE, Somerville E, Sperling MR, Wiebe S, Yacubian EM, Zuberi S.
    • Journal Title

      Epilepsia

      Volume: 60 Issue: 9 Pages: 2003-2005

    • DOI

      10.1111/epi.16308

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K07802
  • [Journal Article] 2017 International League Against Epilepsy classifications of seizures and epilepsy are steps in the right direction.2019

    • Author(s)
      Fisher RS, Cross H, D'Souza C, French JA, Haut S, Higurashi N, Hirsch E, Jansen FE, Peltola J, Moshe SL, Perucca E, Lagae L, Roulet-Perez E, Schulze-Bonhage A, Scheffer IE, Somerville E, Sperling MR, Wiebe S, Yacubian EM, Zuberi S
    • Journal Title

      Epilepsia

      Volume: 60 Issue: 6 Pages: 1040-1044

    • DOI

      10.1111/epi.15052

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K07802
  • [Journal Article] Generation of D1-1 TALEN isogenic control cell line from Dravet syndrome patient iPSCs using TALEN-mediated editing of the SCN1A gene2018

    • Author(s)
      Tanaka Yasuyoshi、Sone Takefumi、Higurashi Norimichi、Sakuma Tetsushi、Suzuki Sadafumi、Ishikawa Mitsuru、Yamamoto Takashi、Mitsui Jun、Tsuji Hitomi、Okano Hideyuki、Hirose Shinichi
    • Journal Title

      Stem Cell Research

      Volume: 28 Pages: 100-104

    • DOI

      10.1016/j.scr.2018.01.036

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K06924, KAKENHI-PROJECT-26461552, KAKENHI-PROJECT-16K18478, KAKENHI-PROJECT-26860833, KAKENHI-PROJECT-18K07802, KAKENHI-PROJECT-15H02548, KAKENHI-PROJECT-16K15532
  • [Journal Article] Establishment of a human induced stem cell line (FUi002-A) from Dravet syndrome patient carrying heterozygous R1525X mutation in SCN1A gene.2018

    • Author(s)
      Tanaka Y, Higurashi N, Shirasu N, Yasunaga S, Moreira KM, Okano H, Hirose S
    • Journal Title

      Stem Cell Res

      Volume: 31 Pages: 11-15

    • DOI

      10.1016/j.scr.2018.06.008

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K07802, KAKENHI-PROJECT-15H02548, KAKENHI-PROJECT-16K15532, KAKENHI-PROJECT-16H06276
  • [Journal Article] Characteristic phasic evolution of convulsive seizure in PCDH19-related epilepsy.2016

    • Author(s)
      1.Ikeda H, Imai K, Ikeda H, Shigematsu H, Takahashi Y, Inoue Y, Higurashi N, Hirose S
    • Journal Title

      Epileptic Disord

      Volume: 18 Issue: 1 Pages: 26-33

    • DOI

      10.1684/epd.2016.0803

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26461552
  • [Journal Article] Efficacy of antiepileptic drugs for the treatment of Dravet syndrome with different genotypes.2015

    • Author(s)
      Shi XY, Tomonoh Y, Wang WZ, Ishii A, Higurashi N, et al.
    • Journal Title

      Brain Dev

      Volume: 38 Issue: 1 Pages: 40-46

    • DOI

      10.1016/j.braindev.2015.06.008

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26461552, KAKENHI-PROJECT-25670481, KAKENHI-PROJECT-15H02548, KAKENHI-PROJECT-16K15532
  • [Journal Article] Immediate suppression of seizure clusters by corticosteroids in PCDH19 female epilepsy.2015

    • Author(s)
      Higurashi N, Takahashi Y, Kashimada A, Sugawara Y, Sakuma H, Tomonoh Y, Inoue T, Hoshina M, Satomi R, Ohfu M, Itomi K, Takano K, Kirino T, Hirose S.
    • Journal Title

      Seizure

      Volume: 27 Pages: 1-5

    • DOI

      10.1016/j.seizure.2015.02.006

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-24249060, KAKENHI-PROJECT-24791095, KAKENHI-PUBLICLY-25129708, KAKENHI-PROJECT-26461552, KAKENHI-PROJECT-15H02548, KAKENHI-PROJECT-25670481
  • [Journal Article] A patient with an early diagnosis of PCDH19-related epilepsy2015

    • Author(s)
      保科めぐみ,日暮憲道,阿部優作,他
    • Journal Title

      NO TO HATTATSU

      Volume: 47 Issue: 4 Pages: 305-309

    • DOI

      10.11251/ojjscn.47.305

    • NAID

      130005111608

    • ISSN
      0029-0831, 1884-7668
    • Language
      Japanese
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26461552
  • [Journal Article] Clinical utility of neuronal cells directly converted from fibroblasts of patients for neuropsychiatric disorders: studies of lysosomal storage diseases and channelopathy.2015

    • Author(s)
      Kano S, Yuan M, Cardarelli RA, Maegawa G, Higurashi N, et al.
    • Journal Title

      Currrent Molecular Medicine

      Volume: 15 Issue: 2 Pages: 138-145

    • DOI

      10.2174/1566524015666150303110300

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24791095, KAKENHI-PROJECT-26461552, KAKENHI-PROJECT-15H02548
  • [Journal Article] PCDH19-related female-limited epilepsy: further details regarding early clinical features and therapeutic efficacy.2013

    • Author(s)
      Higurashi N, Nakamura M, Sugai M, Ohfu M, Sakauchi M, Sugawara Y, Nakamura K, Kato M, Usui D, Mogami Y, Fujiwara Y, Ito T, Ikeda H, Imai K, Takahashi Y, Nukui M, Inoue T, Okazaki S, Kirino T, Tomonoh Y, Inoue T, Takano K, Shimakawa S, Hirose S.
    • Journal Title

      Epilepsy Res

      Volume: 106 Issue: 1-2 Pages: 191-199

    • DOI

      10.1016/j.eplepsyres.2013.04.005

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24249060, KAKENHI-PROJECT-24791095, KAKENHI-PUBLICLY-25129708
  • [Journal Article] 女性に発症するPCDH19関連てんかんの本邦例における臨床的特徴2013

    • Author(s)
      日暮憲道、他
    • Journal Title

      てんかん治療研究財団研究年報

      Volume: 24 Pages: 79-86

    • Data Source
      KAKENHI-PROJECT-24791095
  • [Journal Article] Current Trends in Dravet syndrome Research.2013

    • Author(s)
      Higurashi N, Uchida T, Hirose S, Okano H.
    • Journal Title

      J Neurol Neurophysiol.

      Volume: 4 Issue: 03 Pages: 152-152

    • DOI

      10.4172/2155-9562.1000152

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24249060, KAKENHI-PROJECT-24791095, KAKENHI-PUBLICLY-25129708
  • [Journal Article] The effect of SCN1A mutations on patient-derived GABAergic neurons: what are the implications for future Dravet syndrome therapeutics?2013

    • Author(s)
      Higurashi N, Okano H, Hirose S.
    • Journal Title

      Future Neurol

      Volume: 8 Issue: 5 Pages: 487-489

    • DOI

      10.2217/fnl.13.34

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24249060, KAKENHI-PROJECT-24791095, KAKENHI-PUBLICLY-25129708, KAKENHI-PROJECT-25670481
  • [Journal Article] A human Dravet syndrome model from patient induced pluripotent stem cells.2013

    • Author(s)
      Higurashi N, Uchida T, Lossin C, Misumi Y, Okada Y, Akamatsu W, Imaizumi Y, Zhang B, Nabeshima K, Mori MX, Katsurabayashi S, Shirasaka Y, Okano H, Hirose S.
    • Journal Title

      Mol Brain

      Volume: 6 Issue: 1 Pages: 19-19

    • DOI

      10.1186/1756-6606-6-19

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22689006, KAKENHI-PROJECT-23570149, KAKENHI-PROJECT-23590699, KAKENHI-PROJECT-23618010, KAKENHI-PROJECT-23689017, KAKENHI-PROJECT-24249060, KAKENHI-PROJECT-24791095, KAKENHI-PUBLICLY-25110730, KAKENHI-PUBLICLY-25129708, KAKENHI-PROJECT-25640038, KAKENHI-PROJECT-25670481
  • [Journal Article] PCDH19 Mutation in Japanese Females with Epilepsy2012

    • Author(s)
      Higurashi N, Shi X, Yasumoto S, Oguni K, Itomi K, Miyamoto A, Shirishi H, Kato T, Makita Y, Hirose S.
    • Journal Title

      Epilepsy Res

      Volume: 99 Issue: 1-2 Pages: 28-37

    • DOI

      10.1016/j.eplepsyres.2011.10.014

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21249062, KAKENHI-PROJECT-22791011, KAKENHI-PROJECT-23591488, KAKENHI-PROJECT-23659529
  • [Journal Article] PCDH19 mutation in Japanese females with epilepsy2011

    • Author(s)
      Higurashi N, Shi X, Yasumoto S, Oguni H, Sakauchi M, Itomi K, Miyamoto A, Shiraishi H, Kato T, Makita Y, Hirose S.
    • Journal Title

      Epilepsy Res

      Volume: 99巻 Pages: 28-37

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22791011
  • [Journal Article] 女性に限定されるてんかんと精神遅滞-本邦患者の特徴とPCDH19遺伝子解析を考慮するポイント2011

    • Author(s)
      日暮憲道、廣瀬伸一
    • Journal Title

      日本小児科学会雑誌

      Volume: 115巻 Pages: 1513-1523

    • NAID

      10029836332

    • Data Source
      KAKENHI-PROJECT-22791011
  • [Journal Article] (総説)女性に限定されるてんかんと精神遅滞-本邦患者の特徴とPCDH19遺伝子解析を考慮するポイント2011

    • Author(s)
      日暮憲道, 廣瀬伸一
    • Journal Title

      日本小児科学会雑誌

      Volume: 115 Pages: 1513-1523

    • Data Source
      KAKENHI-PROJECT-22791011
  • [Presentation] Hyperthermia-induced seizures in infancy affect developmental outcome of Scn1a+/- rats2023

    • Author(s)
      Ken Ito, Norimichi Higurashi, Mayu Tahara, and Hironao James Okano
    • Organizer
      16th Asian and Oceanian Congress of Child Neurology (AOCCN 2023)
    • Data Source
      KAKENHI-PROJECT-21K07780
  • [Presentation] Developmental changes in brain activity in Scn1a knockout rats2023

    • Author(s)
      Higurashi N, Tahara M, Hata J, Nishikawa M, Ito K, Hirose S, Okano HJ.
    • Organizer
      16th Asian and Oceanian Congress of Child Neurology (AOCCN 2023)
    • Data Source
      KAKENHI-PROJECT-21K07780
  • [Presentation] PCDH19欠損誘導興奮性神経細胞の形態・機能特性2023

    • Author(s)
      日暮憲道、石川充、田中泰圭、廣瀬伸一、岡野栄之
    • Organizer
      第65回日本小児神経学術大会
    • Invited
    • Data Source
      KAKENHI-PROJECT-21K07780
  • [Presentation] ILAEによるてんかん症候群の分類と定義2022の要点2023

    • Author(s)
      日暮憲道
    • Organizer
      第56回日本てんかん学会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-21K07780
  • [Presentation] Dravet症候群の病態理解の進歩2023

    • Author(s)
      日暮憲道
    • Organizer
      日本脳神経外科学会第82回学術総会
    • Invited
    • Data Source
      KAKENHI-PROJECT-21K07780
  • [Presentation] Scn1aヘテロ欠損ラットで有熱発作が発達予後に与える影響2023

    • Author(s)
      伊藤研、日暮憲道、田原麻由、岡野ジェームス洋尚、大石公彦
    • Organizer
      第56回日本てんかん学会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-21K07780
  • [Presentation] 小児てんかんとILAE分類の特性を理解しよう2022

    • Author(s)
      日暮憲道
    • Organizer
      第14回てんかん学会東海北陸地方会
    • Invited
    • Data Source
      KAKENHI-PROJECT-21K07780
  • [Presentation] 国際抗てんかん連盟「旧分類」を使うのはやめよう!2022

    • Author(s)
      日暮憲道
    • Organizer
      第55回日本てんかん学会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-21K07780
  • [Presentation] 発作群発を特徴とした乳幼児期発症てんかんに対するナトリウムチャネル阻害剤の治療失敗要因の検討2022

    • Author(s)
      日暮憲道、竹内博一、藤賀由梨香、伊藤研、高見遥、田原麻由
    • Organizer
      第64回日本小児神経学会学術集会
    • Data Source
      KAKENHI-PROJECT-21K07780
  • [Presentation] 小児期に発症するてんかん症候群のILAE分類・定義2022

    • Author(s)
      日暮憲道
    • Organizer
      第55回日本てんかん学会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-21K07780
  • [Presentation] Genetics and age-dependent pathogenesis of Dravet syndrome2022

    • Author(s)
      Higurashi N
    • Organizer
      2022 ILAE-AO ASEPA translation symposium
    • Invited
    • Data Source
      KAKENHI-PROJECT-21K07780
  • [Presentation] 小児てんかんの薬物療法2022

    • Author(s)
      日暮憲道
    • Organizer
      第15回てんかん学会関東甲信越地方会
    • Invited
    • Data Source
      KAKENHI-PROJECT-21K07780
  • [Presentation] てんかん学用語集第6版の改訂作業について2021

    • Author(s)
      日暮憲道
    • Organizer
      第54回日本てんかん学会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-21K07780
  • [Presentation] 新しいてんかん・てんかん発作型国際分類の要点と実際2021

    • Author(s)
      日暮憲道
    • Organizer
      第124回日本小児科学会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-21K07780
  • [Presentation] てんかん診療に役立つ「ナトリウムイオンチャネル」2020

    • Author(s)
      日暮憲道
    • Organizer
      第62回日本小児神経学会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-18K07802
  • [Presentation] iPS細胞を用いた小児神経疾患の革新的創薬を見据えた病態解析  PCDH19関連てんかんの病態解析2020

    • Author(s)
      日暮憲道
    • Organizer
      第62回日本小児神経学会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-18K07802
  • [Presentation] Network and molecular mechanisms of generalized spike-waves in DEEs2020

    • Author(s)
      Higurashi N
    • Organizer
      21st Annual Meeting of Infantile Seizure Society International Symposium (ISSET)
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K07802
  • [Presentation] GABAergic failure in epileptogenesis―Dravet syndrome and more2019

    • Author(s)
      Norimichi Higurashi
    • Organizer
      20th Annual Meeting of Infantile Seizure Society
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K07802
  • [Presentation] 発作型分類2017の改訂意義と邦訳版2019

    • Author(s)
      日暮憲道
    • Organizer
      第53回日本てんかん学会学術総会
    • Invited
    • Data Source
      KAKENHI-PROJECT-18K07802
  • [Presentation] 小児てんかん診療の現状と未来-ゲノム医学のインパクト2019

    • Author(s)
      日暮憲道
    • Organizer
      第41回日本小児遺伝学会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-18K07802
  • [Presentation] 小児てんかん診療update 2019 遺伝子異常によるてんかん2019

    • Author(s)
      日暮憲道
    • Organizer
      第61回日本小児神経学会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-18K07802
  • [Presentation] Research topic for DEE (iPSCs and so on)2018

    • Author(s)
      Higurashi N
    • Organizer
      Korea Epilepsy Congress
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K07802
  • [Presentation] Dravet syndrome-Clinical & Genetics2018

    • Author(s)
      Higurashi N
    • Organizer
      19th International Symposium on Severe Infantile Epilepsies
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K07802
  • [Presentation] 2017発作型分類の概要と実際2018

    • Author(s)
      日暮憲道
    • Organizer
      第60回日本小児神経学会総会
    • Invited
    • Data Source
      KAKENHI-PROJECT-18K07802
  • [Presentation] 前頭葉てんかんが疑われた2例における睡眠時Minor motor eventの臨床的意義2017

    • Author(s)
      日暮憲道、菊池健二郎
    • Organizer
      第59回日本小児神経学会総会
    • Data Source
      KAKENHI-PROJECT-26461552
  • [Presentation] Overview of iPSC research on pediatric neurological diseases.2017

    • Author(s)
      Higurashi N
    • Organizer
      14th Asian and Oceanian Congress of Child Neurology
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26461552
  • [Presentation] 患者神経細胞を用いたDravet症候群の病態・治療研究2017

    • Author(s)
      日暮憲道
    • Organizer
      第51回日本てんかん学会学術総会
    • Invited
    • Data Source
      KAKENHI-PROJECT-26461552
  • [Presentation] PCDH19関連てんかんの最新事情2016

    • Author(s)
      日暮憲道、廣瀬伸一
    • Organizer
      第58回日本小児神経学会総会
    • Place of Presentation
      東京
    • Year and Date
      2016-06-04
    • Invited
    • Data Source
      KAKENHI-PROJECT-26461552
  • [Presentation] PCDH19 Female Epilepsy2016

    • Author(s)
      1.Higurashi N, Hirose S
    • Organizer
      53rd Annual Conference of Indian Academy of Pediatrics (PEDICON), 15th Asia Pacific Congress of Pediatrics (APCP)
    • Place of Presentation
      Hyderabad, India
    • Year and Date
      2016-01-23
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26461552
  • [Presentation] Generation of heterozygous (Pcdh19+/-) female rats as a model for PCDH19-related epilepsy2016

    • Author(s)
      Higurashi N, Takata F, Goto A, Uchida T, Ohmori I, Mashimo T, Kataoka Y, Hirose S
    • Organizer
      第50回日本てんかん学会学術総会
    • Place of Presentation
      静岡
    • Year and Date
      2016-10-08
    • Data Source
      KAKENHI-PROJECT-26461552
  • [Presentation] Immediate suppression of seizure clusters by corticosteroids in PCDH19 female epilepsy.2015

    • Author(s)
      Higurashi N, Takahashi Y, Hirose S
    • Organizer
      13th Asian and Oceanian Congress of Child Neurology (AOCCN 2015)
    • Place of Presentation
      Taipei, Taiwan
    • Year and Date
      2015-05-16
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26461552
  • [Presentation] 左片側の持続性部分てんかんを主徴とし、病初期にラスムッセン脳炎が疑われたがびまん性脳萎縮を呈した慢性脳炎の男児例2015

    • Author(s)
      日暮憲道、折津友隆、高橋幸利、佐久間啓、浜野晋一郎、井田博幸
    • Organizer
      第57回日本小児神経学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2015-05-28
    • Data Source
      KAKENHI-PROJECT-26461552
  • [Presentation] New technologies in epilepsy research2015

    • Author(s)
      Higurashi N
    • Organizer
      The 11th Congress of Asian Society for Pediatric Research (ASPR 2015)
    • Place of Presentation
      Osaka
    • Year and Date
      2015-04-16
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26461552
  • [Presentation] Dravet syndrome research using patient-derived induced pluripotent stem cells—Present findings and future directions.2014

    • Author(s)
      Higurashi N, Hirose S
    • Organizer
      Korea Epilepsy Congress (KEC 2014)
    • Place of Presentation
      ソウル(韓国)
    • Year and Date
      2014-06-14
    • Invited
    • Data Source
      KAKENHI-PROJECT-26461552
  • [Presentation] シンポジウム iPS細胞を用いた小児神経疾患の病態解明への期待とその問題点 ②てんかんの病態研究とその問題点2014

    • Author(s)
      日暮憲道
    • Organizer
      第56回日本小児神経学会総会
    • Place of Presentation
      浜松
    • Year and Date
      2014-05-29
    • Invited
    • Data Source
      KAKENHI-PROJECT-26461552
  • [Presentation] Dravet syndrome research using patient-derived induced pluripotent stem cells—Present findings and future directions.2014

    • Author(s)
      Higurashi N, Hirose S
    • Organizer
      Korea Epilepsy Congress (KEC 2014)
    • Place of Presentation
      ソウル(韓国)
    • Year and Date
      2014-06-14
    • Invited
    • Data Source
      KAKENHI-PROJECT-24791095
  • [Presentation] A Powerful Treatment Option for PCDH19-related Epilepsy.2014

    • Author(s)
      Higurashi N, Hirose S
    • Organizer
      PCDH19 Pediatric Epilepsy Professional and Family Symposium
    • Place of Presentation
      サンフランシスコ(米国)
    • Year and Date
      2014-09-06
    • Invited
    • Data Source
      KAKENHI-PROJECT-24791095
  • [Presentation] シンポジウム:iPS細胞を用いた小児神経疾患の病態解明への期待とその問題点 ②てんかんの病態研究とその問題点2014

    • Author(s)
      日暮憲道
    • Organizer
      第56回日本小児神経学会総会
    • Place of Presentation
      浜松
    • Year and Date
      2014-05-29
    • Invited
    • Data Source
      KAKENHI-PROJECT-24791095
  • [Presentation] High prevalence of autoantibodies to N-methyl-D-aspartate receptor and the efficacy of glucocorticoids in PCDH19-related female-limited epilepsy.2014

    • Author(s)
      Higurashi N, et al.
    • Organizer
      13th International Child Neurology Congress
    • Place of Presentation
      イグアス市(ブラジル)
    • Year and Date
      2014-05-05
    • Data Source
      KAKENHI-PROJECT-24791095
  • [Presentation] Potentials of induced pluripotent stem cell-derived neurons in future drug discovery for Dravet syndrome.2014

    • Author(s)
      Higurashi N, et al.
    • Organizer
      The 7th Takeda Science Foundation Symposium on PharmaSciences
    • Place of Presentation
      大阪
    • Data Source
      KAKENHI-PROJECT-24791095
  • [Presentation] Inflammatory aspects of PCDH19-related epilepsy.2014

    • Author(s)
      Higurashi N, et al.
    • Organizer
      第48回日本てんかん学会
    • Place of Presentation
      東京
    • Year and Date
      2014-10-02
    • Data Source
      KAKENHI-PROJECT-24791095
  • [Presentation] PCDH19関連てんかんにおける発症初期の臨床的特徴と治療効果の検討2013

    • Author(s)
      日暮憲道、他
    • Organizer
      第55回日本小児神経学会学術総会
    • Place of Presentation
      大分市
    • Data Source
      KAKENHI-PROJECT-24791095
  • [Presentation] Modeling Dravet syndrome using induced pluripotent stem cells2013

    • Author(s)
      Higurashi N., et al.
    • Organizer
      Pediatric Academic Societies Annual Meeting 2013
    • Place of Presentation
      米国 ワシントンDC
    • Data Source
      KAKENHI-PROJECT-24791095
  • [Presentation] A new research platform for Dravet syndrome using patient-derived induced pluripotent stem cells2013

    • Author(s)
      Higurashi N., et al.
    • Organizer
      XII Workshop on Neurobiology of Epilepsy (WONOEP 2013)
    • Place of Presentation
      カナダ ケベック州ローレンシャン
    • Data Source
      KAKENHI-PROJECT-24791095
  • [Presentation] 患者由来iPS細胞によるDravet症候群モデルの確立と分化GABA性神経細胞における機能低下2013

    • Author(s)
      日暮憲道、他
    • Organizer
      第47回日本てんかん学会
    • Place of Presentation
      北九州市
    • Data Source
      KAKENHI-PROJECT-24791095
  • [Presentation] Dravet Syndrome or EFMR, What Is The Difference? – Can You Tell The Difference?2012

    • Author(s)
      Higurashi N., et al.
    • Organizer
      International Child Neurology Congress & 11th Asian & Oceanian Congress of Child Neurology
    • Place of Presentation
      オーストラリア ブリスベン
    • Invited
    • Data Source
      KAKENHI-PROJECT-24791095
  • [Presentation] Clinical presentations in early phase of PCDH19-related epilepsy2012

    • Author(s)
      Higurashi N, Hirose S
    • Organizer
      9^<th> Asian and Oceanian Epilepsy Congress
    • Place of Presentation
      フィリピン、マニラ(招待講演)
    • Year and Date
      2012-03-22
    • Data Source
      KAKENHI-PROJECT-22791011
  • [Presentation] Clinical presentations in early phase of PCDH19-related epilepsy2012

    • Author(s)
      Higurashi N, Hirose S.
    • Organizer
      9^<th> Asian and Oceanian Epilepsy Congress
    • Place of Presentation
      Manila
    • Data Source
      KAKENHI-PROJECT-22791011
  • [Presentation] Challenges in The Establishment of A Dravet Syndrome Model Using Patient-Derived iPS Cells.2012

    • Author(s)
      Higurashi N., et al.
    • Organizer
      Korean Epilepsy Congress 2012
    • Place of Presentation
      大韓民国 仁川
    • Invited
    • Data Source
      KAKENHI-PROJECT-24791095
  • [Presentation] 本邦女児てんかん患者におけるPCDH19遺伝子解析の現況2011

    • Author(s)
      日暮憲道, 安元佐和, 廣瀬伸一
    • Organizer
      第53回日本小児神経学会総会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-22791011
  • [Presentation] どのような時に"女性に限定されるてんかんと精神遅滞"を疑うか?2011

    • Author(s)
      日暮憲道、廣瀬伸一
    • Organizer
      小児科学会福岡地方会
    • Place of Presentation
      福岡
    • Year and Date
      2011-10-08
    • Data Source
      KAKENHI-PROJECT-22791011
  • [Presentation] どのような時に"女性に限定されるてんかんと精神遅滞"を疑うか2011

    • Author(s)
      日暮憲道、廣瀬伸一
    • Organizer
      小児科学会福岡地方会
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-22791011
  • [Presentation] 本邦女性てんかん患者におけるMLPA法を用いたプロトカドヘリン19欠失の検索2011

    • Author(s)
      日暮憲道, 臼井大介, 高橋幸利, 廣瀬伸一
    • Organizer
      第45回日本てんかん学会
    • Place of Presentation
      新潟
    • Data Source
      KAKENHI-PROJECT-22791011
  • [Presentation] Epilepsy and Mental Retardation Limited to Females-A Disease with Increasing Significance2011

    • Author(s)
      Higurashi N.
    • Organizer
      The 1^<st> international symposium of Research Institute for the Molecular Pathomechanisms of Epilepsy, Fukuoka University
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-22791011
  • [Presentation] PCDH19 mutations and their phenotype in Japanese females with suspected SCN1A-related epilepsy2010

    • Author(s)
      Higurashi N, Hamachi A, Oguni H, Sakauchi M, Itomi K, Miyamoto A, Shiraishi H, Kato T, Hirose S.
    • Organizer
      第52回日本小児神経学会総会
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-22791011
  • [Presentation] PCDH19 mutations and their phenotype in Japanese females with suspected SCN1A-related epilepsy2010

    • Author(s)
      Higurashi N, Hamachi A, Oguni H, Sakauchi M, Itomi K, Miyamoto A, Shiraishi H, Kato T, Hirose S.
    • Organizer
      11^<th> International Child Neurology Congress
    • Place of Presentation
      Cairo
    • Data Source
      KAKENHI-PROJECT-22791011
  • [Presentation] PCDH19 mutations and their phenotypes in Japanese females with suspected SCN1A-related epilepsy2010

    • Author(s)
      日暮憲道
    • Organizer
      世界小児神経学会議(ICNA)
    • Place of Presentation
      グランド・ハイアット・カイロ(エジプト、カイロ)
    • Year and Date
      2010-05-03
    • Data Source
      KAKENHI-PROJECT-22791011
  • [Presentation] PCDH19 mutations and their phenotypes in Japanese females with suspected SCN1A-related epilepsy2010

    • Author(s)
      日暮憲道
    • Organizer
      第52回小児神経学会総会
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2010-05-21
    • Data Source
      KAKENHI-PROJECT-22791011
  • [Presentation] Modeling Dravet syndrome with patient-derived induced pluripotent stem cells and functional vulnerabilities in differentiated GABAergic neurons.

    • Author(s)
      Higurashi N, et al.
    • Organizer
      第47回日本てんかん学会
    • Place of Presentation
      北九州
    • Data Source
      KAKENHI-PROJECT-24791095
  • [Presentation] PCDH19関連てんかんにおける発症初期の臨床的特徴と治療効果の検討

    • Author(s)
      日暮憲道、他
    • Organizer
      第55回日本小児神経学会総会
    • Place of Presentation
      大分
    • Data Source
      KAKENHI-PROJECT-24791095
  • [Presentation] Dravet症候群とPCDH19関連てんかん―診断・鑑別のポイントと発症病態.

    • Author(s)
      日暮憲道
    • Organizer
      第47回日本てんかん学会
    • Place of Presentation
      北九州
    • Invited
    • Data Source
      KAKENHI-PROJECT-24791095
  • [Presentation] A new research platform for Dravet syndrome using patient-derived induced pluripotent stem cells

    • Author(s)
      Higurashi N, et al.
    • Organizer
      XII. Workshop on Neurobiology of the Epilepsy (WONOEP 2013)
    • Place of Presentation
      ケベック(カナダ)
    • Invited
    • Data Source
      KAKENHI-PROJECT-24791095
  • [Presentation] Early clinical features and treatment efficacy of antiepileptic drugs in Japanese patients with PCDH19-related epilepsy.

    • Author(s)
      Higurashi N, et al.
    • Organizer
      2nd Edition of World Conference on PCDH19
    • Place of Presentation
      ローマ(イタリア)
    • Invited
    • Data Source
      KAKENHI-PROJECT-24791095
  • [Presentation] Research on clinical aspects of PCDH19-related epilepsy and induced pluripotent stem cells from a patient with Dravet syndrome: Present findings and future directions.

    • Author(s)
      Higurashi N, et al.
    • Organizer
      7th IGAKUKEN International Symposium on “Fever, Inflammation, and Epilepsy”
    • Place of Presentation
      東京
    • Invited
    • Data Source
      KAKENHI-PROJECT-24791095
  • [Presentation] Modeling Dravet Syndrome Using Induced Pluripotent Stem Cells.

    • Author(s)
      Higurashi N, et al.
    • Organizer
      Pediatric Academic Societies Annual Meeting (PAS 2013)
    • Place of Presentation
      ワシントンDC(米国)
    • Invited
    • Data Source
      KAKENHI-PROJECT-24791095
  • 1.  TAHARA Mayu
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 2.  TAKANO Yukio
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 3.  MORI Masayuki
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 4.  廣瀬 伸一
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 6 results
  • 5.  要 匡
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 6.  柳 久美子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 7.  曽根 岳史
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 8.  佐久間 哲史
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 9.  井上 隆司
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 10.  柴田 磨己
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 11.  森 泰生
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 12.  安永 晋一郎
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 13.  白須 直人
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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