KUBOTA Naoko 窪田直子

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Kubota Naoko 窪田直子

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Researcher Number	40569810
Other IDs
Affiliation (Current)	2025: 鹿児島大学, 医歯学総合研究科, 客員研究員
Affiliation (based on the past Project Information) *help	2021 – 2023: 鹿児島大学, 医歯学総合研究科, 客員研究員 2020: 鹿児島大学, 医歯学域歯学系, 助教 2016 – 2018: 鹿児島大学, 医歯学域歯学系, 助教 2012 – 2014: 鹿児島大学, 医歯(薬)学総合研究科, 助教
Review Section/Research Field	Principal Investigator Basic Section 57070:Developmental dentistry-related / Orthodontics/Pediatric dentistry / Tumor biology
Keywords	Principal Investigator ヒト乳歯歯髄細胞 / アルカリホスファターゼ / 遺伝子工学的手法 / piggybacシステム / CRISPR/Cas9 / PiggyBacシステム / 生体内遺伝子導入 / 遺伝子工学的処理 / Oct-3/4 / 癌幹細胞

ヒト乳歯歯髄細胞への分子生物学的介入による幹細胞誘導とそれを用いた機能解析Principal Investigator
- Principal Investigator
  
  窪田直子
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57070:Developmental dentistry-related
- Research Institution
  Kagoshima University
Functional analysis of alkaline phosphatase, a stem cell marker, using human deciduous dental pulp cells derived from the patient with Hypophosphatasia (HPP)Principal Investigator
- Principal Investigator
  
  Kubota Naoko
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57070:Developmental dentistry-related
- Research Institution
  Kagoshima University
Development of gene transfer to peripheral tissues surrounding tooth (GTPT) for the tissue around the root forming apex of juvenile mice and its applicationPrincipal Investigator
- Principal Investigator
  
  Kubota Naoko
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthodontics/Pediatric dentistry
- Research Institution
  Kagoshima University
Oct-3/4, a member of the family of POU-domain transcriptional factors can be the promising markers for cancer stem cells.Principal Investigator
- Principal Investigator
  
  KUBOTA Naoko
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor biology
- Research Institution
  Kagoshima University

All 2022 2021 2020 2019 2018 2017 2016 2014 2013 2012 Other

All Journal Article Presentation

[Journal Article] The Role of Genetically Modified Human Feeder Cells in Maintaining the Integrity of Primary Cultured Human Deciduous Dental Pulp Cells.2022
- Author(s)
  Ibano N、Inada E、Otake S、Kiyokawa Y、Sakata K、Sato M、Kubota N、Noguchi H、Iwase Y、Murakami T、Sawami T、Kakihara Y、Maeda T、Terunuma M、Terao Y、Saitoh I
- Journal Title
  
  Journal of Clinical Medicine
  
  Volume: 11 Issue: 20 Pages: 6087-6087
- DOI
  10.3390/jcm11206087
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K10165, KAKENHI-PROJECT-21K19537, KAKENHI-PROJECT-20H03745, KAKENHI-PROJECT-20K10009, KAKENHI-PROJECT-20K10210, KAKENHI-PROJECT-23K24535
[Journal Article] RNA analysis based on a small number of manually isolated fixed cells (RNA-snMIFxC) to profile stem cells from human deciduous tooth-derived dental pulp cells2021
- Author(s)
  Inada E, Saitoh I, Kubota N, Iwase Y, Kiyokawa Y, Noguchi H, Yamasaki Y, Sato M
- Journal Title
  
  Biological Procedure Online
  
  Volume: 23 Issue: 1 Pages: 12-12
- DOI
  10.1186/s12575-021-00149-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K06372, KAKENHI-PROJECT-20H03745, KAKENHI-PROJECT-20K10210, KAKENHI-PROJECT-21K10165, KAKENHI-PROJECT-21K19537
[Journal Article] Tissue-nonspecific alkaline phosphatase, a possible mediator of cell maturation: Towards a new paradigm2021
- Author(s)
  Sato M, Saitoh I, Kiyokawa, Iwase Y, Kubota N, Ibano N, Noguchi H, Yamasaki Y, Inada E
- Journal Title
  
  Cells
  
  Volume: 10 Issue: 12 Pages: 3338-3338
- DOI
  10.3390/cells10123338
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K06372, KAKENHI-PROJECT-20H03745, KAKENHI-PROJECT-20K10009, KAKENHI-PROJECT-20K10210, KAKENHI-PROJECT-21K10165, KAKENHI-PROJECT-21K19537
[Journal Article] Drug-induced naive iPS cells exhibit better performance than primed iPS cells with respect to the ability to differentiate into pancreatic β-cell lineage2020
- Author(s)
  Kiyokawa Y, Sato M, Noguchi H, Inada E, Iwase Y, Kubota N, Sawami T, Terunuma M, Maeda T, Hayasaki H, Saitoh I
- Journal Title
  
  Journal of Clinical Medicine
  
  Volume: 9 Issue: 9 Pages: 2838-2838
- DOI
  10.3390/jcm9092838
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K06372, KAKENHI-PROJECT-20K10210, KAKENHI-PROJECT-18KK0258, KAKENHI-PROJECT-17H04412, KAKENHI-PROJECT-20H03745, KAKENHI-PROJECT-18K09839
[Journal Article] Repeated human deciduous tooth-derived dental pulp cell reprogramming factor transfection yields multipotent intermediate cells with enhanced iPS cell formation capability2019
- Author(s)
  Soda Miki、Saitoh Issei、Murakami Tomoya、Inada Emi、Iwase Yoko、Noguchi Hirofumi、Shibasaki Shinji、Kurosawa Mie、Sawami Tadashi、Terunuma Miho、Kubota Naoko、Terao Yutaka、Ohshima Hayato、Hayasaki Haruaki、Sato Masahiro
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 1490-1490
- DOI
  10.1038/s41598-018-37291-2
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09839, KAKENHI-PROJECT-16H05404, KAKENHI-PROJECT-17H04366, KAKENHI-PROJECT-16K10436, KAKENHI-PROJECT-16K11810, KAKENHI-PROJECT-17K11956, KAKENHI-PROJECT-17K17318, KAKENHI-PROJECT-17K11953, KAKENHI-PROJECT-19K06372, KAKENHI-PROJECT-17K11957, KAKENHI-PROJECT-17H04412
[Journal Article] Increased Expression of Cell Surface SSEA-1 is Closely Associated with Na?ve-Like Conversion from Human Deciduous Teeth Dental Pulp Cells-Derived iPS Cells2019
- Author(s)
  Inada Emi、Saitoh Issei、Kubota Naoko、Iwase Yoko、Murakami Tomoya、Sawami Tadashi、Yamasaki Youichi、Sato Masahiro
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 20 Issue: 7 Pages: 1651-1651
- DOI
  10.3390/ijms20071651
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09839, KAKENHI-PROJECT-16K11810, KAKENHI-PROJECT-17K11956, KAKENHI-PROJECT-17K17318, KAKENHI-PROJECT-19K06372, KAKENHI-PROJECT-17K11957, KAKENHI-PROJECT-17H04412
[Journal Article] Intrapancreatic Parenchymal Injection of Cells as a Useful Tool for Allowing a Small Number of Proliferative Cells to Grow In Vivo.2017
- Author(s)
  Sato M, Saitoh I, Murakami T, Kubota N, Nakamura S, Watanabe S, Inada E
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 18 Issue: 8 Pages: 1678-1678
- DOI
  10.3390/ijms18081678
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K11810, KAKENHI-PROJECT-16K15063, KAKENHI-PROJECT-17K17318, KAKENHI-PROJECT-16H05049, KAKENHI-PROJECT-15K07695
[Journal Article] Alkaline phosphatase and OCT-3/4 as useful markers for predicting susceptibility of human deciduous teeth-derived dental pulp cells to reprogramming factor-induced iPS cells2016
- Author(s)
  Inada E, Saitoh I, Miura H, Ohtsuka M, Murakami T, Sawami T, Yamasaki Y, Watanabe S, Aoki R, Sato M
- Journal Title
  
  Journal of Investigative and Clinical Dentistry
  
  Volume: - Issue: 4 Pages: 1-11
- DOI
  10.1111/jicd.12236
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15J03924, KAKENHI-PROJECT-25463192, KAKENHI-PROJECT-15K07695, KAKENHI-PROJECT-16K11810
[Journal Article] Morphological differences of facial soft tissue contours from child to adult of Japanese males: A three-dimensional cross-sectional study.2014
- Author(s)
  Murakami D, Inada E, Saitoh I, Takemoto Y, Morizono K, Kubota N, Iwasaki T, Oku T, Yamasaki Y
- Journal Title
  
  Archives of Oral Biology
  
  Volume: 59 Issue: 12 Pages: 1391-1399
- DOI
  10.1016/j.archoralbio.2014.08.004
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24501317, KAKENHI-PROJECT-24792298, KAKENHI-PROJECT-25463192, KAKENHI-PROJECT-25463193
[Journal Article] Hela Cells Consist of Two Cell Types, as Evidenced by Cytochemical Staining for Alkaline Phosphatase Activity: A Possible Model for Cancer Stem Cell Study2013
- Author(s)
  Masahiro Sato, Naoko Kubota, Emi Inada, Issei Saitoh, Masato Ohtsuka,Shingo Nakamura, Takayuki Sakurai and Satoshi Watanabe
- Journal Title
  
  Advances in Stem Cells
  
  Volume: Article ID 208514 Pages: 208514-208514
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24501317
[Journal Article] Hela cells consist of two cell types, as evidenced by cytochemical staining for alkaline phosphatase activity: A possible model for cancer stem cell study.2013
- Author(s)
  Sato　M, Kubota N, Inada E, Saitoh I, Ohtsuka M, Nakamura S, Sakurai T, Watanabe S
- Journal Title
  
  Advances in Stem Cells
  
  Volume: 2013 Pages: 15-15
- DOI
  10.5171/2013.208514
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592892, KAKENHI-PROJECT-23593038, KAKENHI-PROJECT-23700562, KAKENHI-PROJECT-24501317, KAKENHI-PROJECT-24580411, KAKENHI-PROJECT-25463192, KAKENHI-PLANNED-22133002
[Journal Article] Mosaic Expression of Pluripotency-Related Proteins Oct-3/4 and Alkaline Phosphatase in Human Pancreatic Carcinoma Cell PANC-12013
- Author(s)
  Sato M, Maeda S, Inada E, Saitoh I, Kubota N
- Journal Title
  
  Advanced Studies in Biology
  
  Volume: 5 Pages: 157-172
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24501317
[Journal Article] Mosaic Expression of Pluripotency-Related Proteins Oct-3/4 and Alkaline Phosphatase in Human Pancreatic Carcinoma Cell PANC-12013
- Author(s)
  Masahiro Sato, Shin-ichi Maeda, Emi Inada, Issei Saitoh, Naoko Kubota
- Journal Title
  
  Advanced Studies in Biology
  
  Volume: ５ Pages: 157-172
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24501317
[Presentation] 初期胚特異的糖鎖抗原SSEA-1は乳歯歯髄細胞由来iPS細胞の高度未分化状態を特定するマーカーとして有用である2018
- Author(s)
  稲田絵美, 齊藤一誠, 窪田直子, 村上智哉, 澤味規, 松枝一成, 早崎治明, 山崎要一
- Organizer
  第56回日本小児歯科学会
- Data Source
  KAKENHI-PROJECT-16K11810
[Presentation] 少数個の増殖性細胞の体内増殖を可能とする新規マウス膵臓内細胞移植法2017
- Author(s)
  佐藤正宏、齋藤一誠、村上智哉、窪田直子、中村伸吾、渡部聡、稲田絵美
- Organizer
  第40回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-16K11810
[Presentation] ヒト乳歯歯髄由来iPS細胞樹立におけるフィーダー細胞選択の重要性2013
- Author(s)
  村上智哉, 齊藤一誠, 稲田絵美, 岩瀬陽子, 長谷川大子, 窪田直子, 松本祐子, 大島邦子, 岡暁子, 山崎要一, 早崎治明
- Organizer
  第５１回日本小児歯科学会
- Place of Presentation
  岐阜
- Data Source
  KAKENHI-PROJECT-24501317
[Presentation] 小児の口呼吸における関連因子の抽出と口唇閉鎖力との関連性についての先行研究2012
- Author(s)
  村上大輔稲田絵美, 齊藤一誠, 海原康孝, 奥猛志, 岩崎智憲, 長谷川大子, 深水篤, 佐藤秀夫, 武元嘉彦, 窪田直子, 伊藤千晶, 乃村俊樹, 田中みゆき, 井形紀子, 香西克之, 山崎要一
- Organizer
  第５０回日本小児歯科学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24501317
[Presentation] piggyBac-transposon-mediated gene-delivery efficiently generates stable transfectants from HDDPCs and HDDPC-derived-iPSCs.
- Author(s)
  Soda M, Saitoh I, Inada E, Murakami T, Iwase Y, Kubota N, Sawami T, Matsumoto Y, Yamasaki Y, Hayasaki H, Ohshima H, Sato M
- Organizer
  IADR
- Place of Presentation
  Boston (America)
- Year and Date
  2015-03-11 – 2015-03-14
- Data Source
  KAKENHI-PROJECT-24501317
[Presentation] PiggyBacトランスポゾンによるヒト乳歯髄細胞からの遺伝子導入安定株の効率的取得
- Author(s)
  稲田絵美，齊藤一誠，窪田直子，松本祐子，村上智哉，澤味規，山﨑要一
- Organizer
  第５２回日本小児歯科学会
- Place of Presentation
  東京都（品川区立総合区民会館）
- Year and Date
  2014-05-16 – 2014-05-17
- Data Source
  KAKENHI-PROJECT-24501317

1. SATO Masahiro (30287099)

# of Collaborated Projects: 4 results

# of Collaborated Products: 14 results
2. NOGUCHI Hirofumi (50378733)

# of Collaborated Projects: 4 results

# of Collaborated Products: 2 results
3. SAITOH Issei (90404540)

# of Collaborated Projects: 4 results

# of Collaborated Products: 15 results
4. INADA Emi (30448568)

# of Collaborated Projects: 4 results

# of Collaborated Products: 15 results
5. SAITOH Yoko (30404487)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results

KUBOTA Naoko 窪田 直子

Kubota Naoko 窪田 直子

Research Projects

Research Products

Co-Researchers

ヒト乳歯歯髄細胞への分子生物学的介入による幹細胞誘導とそれを用いた機能解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Functional analysis of alkaline phosphatase, a stem cell marker, using human deciduous dental pulp cells derived from the patient with Hypophosphatasia (HPP)Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of gene transfer to peripheral tissues surrounding tooth (GTPT) for the tissue around the root forming apex of juvenile mice and its applicationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Oct-3/4, a member of the family of POU-domain transcriptional factors can be the promising markers for cancer stem cells.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] The Role of Genetically Modified Human Feeder Cells in Maintaining the Integrity of Primary Cultured Human Deciduous Dental Pulp Cells.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] RNA analysis based on a small number of manually isolated fixed cells (RNA-snMIFxC) to profile stem cells from human deciduous tooth-derived dental pulp cells2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Tissue-nonspecific alkaline phosphatase, a possible mediator of cell maturation: Towards a new paradigm2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Drug-induced naive iPS cells exhibit better performance than primed iPS cells with respect to the ability to differentiate into pancreatic β-cell lineage2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Repeated human deciduous tooth-derived dental pulp cell reprogramming factor transfection yields multipotent intermediate cells with enhanced iPS cell formation capability2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Increased Expression of Cell Surface SSEA-1 is Closely Associated with Na?ve-Like Conversion from Human Deciduous Teeth Dental Pulp Cells-Derived iPS Cells2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Intrapancreatic Parenchymal Injection of Cells as a Useful Tool for Allowing a Small Number of Proliferative Cells to Grow In Vivo.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Alkaline phosphatase and OCT-3/4 as useful markers for predicting susceptibility of human deciduous teeth-derived dental pulp cells to reprogramming factor-induced iPS cells2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Morphological differences of facial soft tissue contours from child to adult of Japanese males: A three-dimensional cross-sectional study.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Hela Cells Consist of Two Cell Types, as Evidenced by Cytochemical Staining for Alkaline Phosphatase Activity: A Possible Model for Cancer Stem Cell Study2013

Author(s)

Journal Title

Data Source

[Journal Article] Hela cells consist of two cell types, as evidenced by cytochemical staining for alkaline phosphatase activity: A possible model for cancer stem cell study.2013

Author(s)

KUBOTA Naoko 窪田直子

Kubota Naoko 窪田直子