Chiyonobu Tomohiro 千代延友裕

… Alternative Names

CHIYONOBU Tomohiro 千代延友裕

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Researcher Number	40571659
Other IDs
Affiliation (Current)	2025: 京都府立医科大学, 医学(系)研究科(研究院), 講師
Affiliation (based on the past Project Information) *help	2025: 京都府立医科大学, 医学(系)研究科(研究院), 講師 2021 – 2023: 京都府立医科大学, 医学(系)研究科(研究院), 講師 2013 – 2020: 京都府立医科大学, 医学(系)研究科(研究院), 助教
Review Section/Research Field	Principal Investigator Basic Section 52050:Embryonic medicine and pediatrics-related / Pediatrics / Neurochemistry/Neuropharmacology Except Principal Investigator Basic Section 52050:Embryonic medicine and pediatrics-related / Embryonic/Neonatal medicine
Keywords	Principal Investigator STXBP1 / iPS細胞 / ショウジョウバエ / てんかん性脳症 / αシヌクレイン / リボソーム病 / リボソーム / 神経発達症 / 精神運動発達遅滞 / SCN1A … More / syntaxin-1 / 発達遅滞 / PIGW / STXBPI … More Except Principal Investigator 小児難治てんかん / ゲノム編集 / iPS細胞 / mTOR / AKT3 / ルテオリン / 神経凝集体 / 神経分化 / インターロイキン6 / iPS 細胞 Less

機能獲得型変異による難治てんかんに対するアレル特異的サイレンシング治療の検証Principal Investigator
- Principal Investigator
  
  千代延友裕
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Kyoto Prefectural University of Medicine
Molecular pathology investigation for targeted therapy of intractable pediatric epilepsy via mTOR pathway hyperactivation
- Principal Investigator
  
  森本昌史
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Kyoto Prefectural University of Medicine
Search for targeted therapies for alpha-synuclein-induced neurotoxicity in STXBP1 encephalopathyPrincipal Investigator
- Principal Investigator
  
  Chiyonobu Tomohiro
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Kyoto Prefectural University of Medicine
Uncovering the pathophysiological mechanisms of neurodevelopmental disorders associated with ribosomopathies using DrosophilaPrincipal Investigator
- Principal Investigator
  
  Chiyonobu Tomohiro
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Kyoto Prefectural University of Medicine
Drug discovery study improves the outcomes of epileptic encephalopathyPrincipal Investigator
- Principal Investigator
  
  CHIYONOBU Tomohiro
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Kyoto Prefectural University of Medicine
Modeling the neural impact of maternal immune modulation using human induced pluripotent stem cells.
- Principal Investigator
  
  MASAFUMI MORIMOTO
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Embryonic/Neonatal medicine
- Research Institution
  Kyoto Prefectural University of Medicine
Modeling the neuronal phenotype of epileptic encephalopathy using patient-derived iPSCsPrincipal Investigator
- Principal Investigator
  
  CHIYONOBU Tomohiro
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Kyoto Prefectural University of Medicine

All 2024 2023 2021 2020 2019 2017 2016 2015 2014 Other

All Journal Article Presentation

[Journal Article] α-Synuclein pathology in Drosophila melanogaster is exacerbated by haploinsufficiency of Rop: connecting STXBP1 encephalopathy with α-synucleinopathies2024
- Author(s)
 Matsuoka Taro、Yoshida Hideki、Kasai Takashi、Tozawa Takenori、Iehara Tomoko、Chiyonobu Tomohiro
- Journal Title
 
 Human Molecular Genetics
 
 Volume: - Issue: 15 Pages: 1328-1338
- DOI
 10.1093/hmg/ddae073
- Peer Reviewed
- Data Source
 KAKENHI-PROJECT-21K07855
[Journal Article] Impaired neuronal activity and differential gene expression in STXBP1 encephalopathy patient iPSC-derived GABAergic neurons2021
- Author(s)
  Ichise Eisuke、Chiyonobu Tomohiro、Ishikawa Mitsuru、Tanaka Yasuyoshi、Shibata Mami、Tozawa Takenori、Taura Yoshihiro、Yamashita Satoshi、Yoshida Michiko、Morimoto Masafumi、Higurashi Norimichi、Yamamoto Toshiyuki、Okano Hideyuki、Hirose Shinichi
- Journal Title
  
  Human Molecular Genetics
  
  Volume: - Issue: 14 Pages: 1337-1348
- DOI
  10.1093/hmg/ddab113
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K17347, KAKENHI-PROJECT-20K16898, KAKENHI-PROJECT-21K07780, KAKENHI-PROJECT-21K07855, KAKENHI-PROJECT-21K07873
[Journal Article] A novel Drosophila model for neurodevelopmental disorders associated with Shwachman-Diamond syndrome2020
- Author(s)
  Takai Akari、Chiyonobu Tomohiro、Ueoka Ibuki、Tanaka Ryo、Tozawa Takenori、Yoshida Hideki、Morimoto Masafumi、Hosoi Hajime、Yamaguchi Masamitsu
- Journal Title
  
  Neuroscience Letters
  
  Volume: 739 Pages: 135449-135449
- DOI
  10.1016/j.neulet.2020.135449
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07796
[Journal Article] Novel genetic link between the ATP-binding cassette subfamily A gene and hippo gene in Drosophila.2020
- Author(s)
  Ueoka I, Takai A, Chiyohobu T, Yoshida H and Yamaguchi M.
- Journal Title
  
  Exp. Cell Res.
  
  Volume: 386 Issue: 2 Pages: 111733-111733
- DOI
  10.1016/j.yexcr.2019.111733
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07500, KAKENHI-PROJECT-19K06659, KAKENHI-PROJECT-18K07796
[Journal Article] Investigating Developmental and Epileptic Encephalopathy Using Drosophila melanogaster2020
- Author(s)
  Takai Akari、Yamaguchi Masamitsu、Yoshida Hideki、Chiyonobu Tomohiro
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 21 Issue: 17 Pages: 6442-6442
- DOI
  10.3390/ijms21176442
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07796
[Journal Article] Identification of novel BCL11A variants in patients with epileptic encephalopathy: Expanding the phenotypic spectrum2017
- Author(s)
  Yoshida M.、Nakashima M.、Okanishi T.、Kanai S.、Fujimoto A.、Itomi K.、Morimoto M.、Saitsu H.、Kato M.、Matsumoto N.、Chiyonobu T.
- Journal Title
  
  Clinical Genetics
  
  Volume: 93 Issue: 2 Pages: 368-373
- DOI
  10.1111/cge.13067
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05160, KAKENHI-PROJECT-15K09628
[Journal Article] Luteolin attenuates interleukin-6-mediated astrogliosis in human iPSC-derived neural aggregates: A candidate preventive substance for maternal immune activation-induced abnormalities2017
- Author(s)
  Zuiki Masashi、Chiyonobu Tomohiro、Yoshida Michiko、Maeda Hiroshi、Yamashita Satoshi、Kidowaki Satoshi、Hasegawa Tatsuji、Gotoh Hitoshi、Nomura Tadashi、Ono Katsuhiko、Hosoi Hajime、Morimoto Masafumi
- Journal Title
  
  Neuroscience Letters
  
  Volume: 653 Pages: 296-301
- DOI
  10.1016/j.neulet.2017.06.004
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K18010, KAKENHI-PROJECT-15K09719
[Journal Article] Mislocalization of syntaxin-1 and impaired neurite growth observed in a human iPSC model for STXBP1-related epileptic encephalopathy.2016
- Author(s)
  Yamashita S, Chiyonobu T, Yoshida M, Maeda H, Zuiki M, Kidowaki S, Isoda K, Morimoto M, Kato M, Saitsu H, Matsumoto N, Nakahata T, Saito MK, Hosoi H
- Journal Title
  
  Epilepsia
  
  Volume: 57 Issue: 4
- DOI
  10.1111/epi.13338
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09628, KAKENHI-ORGANIZER-24118001, KAKENHI-PLANNED-24118007
[Journal Article] Establishment of isogenic iPSCs from an individual with SCN1A mutation mosaicism as a model for investigating neurocognitive impairment in Dravet syndrome.2016
- Author(s)
  Maeda H, Chiyonobu T, Yoshida M, Yamashita S, Zuiki M, Kidowaki S, Isoda K, Yamakawa K, Morimoto M, Nakahata T, Saito MK, Hosoi H.
- Journal Title
  
  J Hum Genet.
  
  Volume: 印刷中 Issue: 6 Pages: 565-569
- DOI
  10.1038/jhg.2016.5
- NAID
  40020857171
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26670498, KAKENHI-PROJECT-15K09628
[Journal Article] Glycosylphosphatidylinositol (GPI) anchor deficiency caused by mutations in PIGW is associated with West syndrome and hyperphosphatasia with mental retardation syndrome.2014
- Author(s)
  Chiyonobu T, Inoue N, Morimoto M, Kinoshita T, Murakami Y
- Journal Title
  
  Journal of Medical Genetics
  
  Volume: 51 Pages: 203-207
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25870617
[Presentation] alpha-Synuclein pathology is exacerbated by haploinsufficiency of Rop, the STXBP1 homolog in Drosophila melanogaster.2023
- Author(s)
  Matsuoka T, Yoshida H, Kasai T, Tozawa T, Chiyonobu T.
- Organizer
  日本人類遺伝学会第68回大会
- Data Source
  KAKENHI-PROJECT-21K07855
[Presentation] alpha-Synuclein pathology in Drosophila melanogaster is exacerbated by haploinsufficiency of Rop: Connecting STXBP1 encephalopathy with alpha-synucleinopathies.2023
- Author(s)
  Matsuoka T, Yoshida H, Kasai T, Tozawa T, Chiyonobu T.
- Organizer
  American Society of Human Genetics Annual Meeting 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07855
[Presentation] Impaired activity and differential gene expression in STXBP1 encepalopathy patient iPSC-derived GABAergic neurons.2021
- Author(s)
  Ichise E, Chiyonobu T, Ishikawa M, Tanaka Y, Shibata M, Tozawa T, Yamashita S, Yoshida M, Morimoto M, Higurashi N, Yamamoto T, Okano H, Hirose S.
- Organizer
  日本人類遺伝学会第66回大会
- Data Source
  KAKENHI-PROJECT-21K07855
[Presentation] Functional and transcriptomic analysis of STXBP1 encephalopathy iPSC-derived GABAergic neurons.2021
- Author(s)
  Ichise E, Chiyonobu T, Ishikawa M, Tanaka Y, Tozawa T, Yamashita S, Yoshida M, Higurashi N, Yamamoto T, Okano H, Hirose S.
- Organizer
  第63回日本小児神経学会学術集会
- Data Source
  KAKENHI-PROJECT-21K07855
[Presentation] ショウジョウバエを用いた神経発達症研究－リボソーム病への応用－2020
- Author(s)
  高井あかり、千代延友裕、上岡伊吹、田中領、戸澤雄紀、吉田英樹、森本昌史、山口政光
- Organizer
  第62回日本小児神経学会学術集会
- Data Source
  KAKENHI-PROJECT-18K07796
[Presentation] ショウジョウバエモデルで明らかにしたALS，CMT，ASDへのHippo遺伝子の関与2020
- Author(s)
  山口政光、東裕美子、櫛村由紀恵、上岡伊吹、高井あかり、吉田英樹、千代延友裕、徳田隆彦
- Organizer
  第72回日本細胞生物学会
- Data Source
  KAKENHI-PROJECT-18K07796
[Presentation] ショウジョウバエモデルを用いたリボソーム生合成異常による神経発達症の病態解析2019
- Author(s)
  高井あかり、千代延友裕、上岡伊吹、山口瑞季、田中領、吉田英樹、山口政光
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18K07796
[Presentation] ルテオリンはIL-6による神経分化障害を改善するーヒトiPS細胞を用いた母体炎症による胎児脳障害の治療探索2017
- Author(s)
  瑞木匡、千代延友裕、前田裕史、山下哲史、吉田路子、長谷川龍志、森本昌史
- Organizer
  第59回日本小児神経学会学術集会
- Data Source
  KAKENHI-PROJECT-15K09719
[Presentation] A human iPSC model of STXBP1-related epileptic encephalopathy uncovers specific neural dysfunctions.2017
- Author(s)
  Yamashita S, Chiyonobu T, Yoshida M, Maeda H, Zuiki M, Kidowaki S, Isoda K, Kato M, Saitsu H, Matsumoto N, Morimoto M
- Organizer
  14th Asian and Oceanian Congress of Child Neurology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09628
[Presentation] Establishment of isogenic iPSCs from an individual with SCN1A mutation mosaicism as a model for investigating neurocognitive impairment in Dravet syndrome.2016
- Author(s)
  Chiyonobu T, Maeda H, Yoshida M, Yamashita S, Zuiki M, Nakahata T, Saito MK, Morimoto M.
- Organizer
  The 14th International Child Neurology Congress.
- Place of Presentation
  Amsterdam, the Netherlands.
- Year and Date
  2016-05-01
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09628
[Presentation] SCN1A変異モザイク個人由来iPS細胞の樹立と病態解析への応用．2016
- Author(s)
  前田裕史, 千代延友裕，吉田路子, 山下哲史, 瑞木匡，木戸脇智志，磯田賢一，森本昌史．
- Organizer
  第50回日本てんかん学会学術集会
- Place of Presentation
  静岡
- Year and Date
  2016-10-07
- Data Source
  KAKENHI-PROJECT-15K09628
[Presentation] Modeling the cellular phenotype of STXBP1-related epileptic encephalopathy using iPSC.2016
- Author(s)
  Yamashita S, Chiyonobu T, Yoshida M, Maeda H, Zuiki M, Kato M, Saitsu H, Matsumoto N, Nakahata T, Saito MK, Morimoto M.
- Organizer
  The 14th International Child Neurology Congress.
- Place of Presentation
  Amsterdam, the Netherlands.
- Year and Date
  2016-05-01
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09628
[Presentation] Modeling the cellular phenotype of STXBP1-related epileptic encephalopathy using iPSC.2016
- Author(s)
  Yamashita S, Chiyonobu T, Yoshida M, Maeda H, Zuiki M, Kidowaki S, Isoda K, Morimoto M, Kato M, Saitsu H, Matsumoto N, Nakahata T, Saito MK, Hosoi H.
- Organizer
  第58回日本小児神経学会学術集会
- Place of Presentation
  東京
- Year and Date
  2016-06-02
- Data Source
  KAKENHI-PROJECT-15K09628
[Presentation] Modeling the neural impact of maternal immune activation using human induced pluripotent stem cells.2016
- Author(s)
  Zuiki M, Chiyonobu T, Yoshida M, Kidowaki S, Yamashita S, Hasegawa T, Morimoto M.
- Organizer
  The 14th International Child Neurology Congress
- Place of Presentation
  Amsterdam, the Netherlands
- Year and Date
  2016-05-01
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09719
[Presentation] Refractory epileptic encephalopathy in a case with cardio-facio-cutaneous syndrome caused by MAP2K1 mutation.2015
- Author(s)
  Chiyonobu T, Kato M, Maeda H, Kidowaki S, Yamashita S, Zuiki M, Morimoto M, Nakashima M, Matsumoto N, Hosoi H
- Organizer
  The 13th Asian and Oceanian Congress of Child Neurology
- Place of Presentation
  Taipei, Taiwan
- Year and Date
  2015-05-14
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09628
[Presentation] Mislocalization of syntaxin-1 and impaired neurite growth observed in a human iPSC model for STXBP1-related epileptic encephalopathy.2015
- Author(s)
  Yamashita S, Chiyonobu T, Yoshida M, Maeda H, Zuiki M, Kidowaki S, Isoda K, Morimoto M, Kato M, Saitsu H, Matsumoto N, Nakahata T, Saito MK, Hosoi H
- Organizer
  Society for Neuroscience 45th Annual Meeting
- Place of Presentation
  Chicago, USA
- Year and Date
  2015-10-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09628
[Presentation] Isogenic iPSCs from an individual with SCN1A mutation mosaicism revealed aberrant dopamine levels in Dravet syndrome neurons.2015
- Author(s)
  Maeda H, Chiyonobu T, Yoshida M, Yamashita S, Zuiki M, Kidowaki S, Isoda K, Morimoto M, Nakahata T, Saito MK, Hosoi H
- Organizer
  Society for Neuroscience 45th Annual Meeting
- Place of Presentation
  Chicago, USA
- Year and Date
  2015-10-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09628
[Presentation] Inherited GPI anchor deficiency is associated with West syndrome.
- Author(s)
  Chiyonobu T, Inoue N, Morimoto M, Kinoshita T, Murakami Y
- Organizer
  The 16th Annual Meeting of Infantile Seizure Society
- Place of Presentation
  Cappadocia, Turkey
- Year and Date
  2014-06-23 – 2014-06-25
- Data Source
  KAKENHI-PROJECT-25870617
[Presentation] Inherited GPI anchor deficiency: biochemical, molecular, and clinical presentation of a patient with PIGW mutation.
- Author(s)
  Chiyonobu T, Inoue N, Morimoto M, Kinoshita T, Murakami Y
- Organizer
  American Society of Human Genetics 64th Annual Meeting
- Place of Presentation
  San Diego, CA, USA
- Year and Date
  2014-10-18 – 2014-10-22
- Data Source
  KAKENHI-PROJECT-25870617

1. MASAFUMI MORIMOTO (10285265)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
2. 吉田英樹 (30570600)

# of Collaborated Projects: 2 results

# of Collaborated Products: 10 results
3. 笠井高士 (70516062)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
4. 石川充 (10613995)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. YOSHIDA Michiko

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
6. YAMASHITA Satoshi

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
7. MAEDA Hiroshi

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
8. ZUIKI Masashi

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
9. 柴田磨己

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 山口政光

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 才津浩智

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 中畑龍俊

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Chiyonobu Tomohiro 千代延 友裕

CHIYONOBU Tomohiro 千代延 友裕

Research Projects

Research Products

Co-Researchers

機能獲得型変異による難治てんかんに対するアレル特異的サイレンシング治療の検証Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular pathology investigation for targeted therapy of intractable pediatric epilepsy via mTOR pathway hyperactivation

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Search for targeted therapies for alpha-synuclein-induced neurotoxicity in STXBP1 encephalopathyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Uncovering the pathophysiological mechanisms of neurodevelopmental disorders associated with ribosomopathies using DrosophilaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Drug discovery study improves the outcomes of epileptic encephalopathyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Modeling the neural impact of maternal immune modulation using human induced pluripotent stem cells.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Modeling the neuronal phenotype of epileptic encephalopathy using patient-derived iPSCsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] α-Synuclein pathology in <i>Drosophila melanogaster</i> is exacerbated by haploinsufficiency of <i>Rop</i>: connecting <i>STXBP1</i> encephalopathy with α-synucleinopathies2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Impaired neuronal activity and differential gene expression in STXBP1 encephalopathy patient iPSC-derived GABAergic neurons2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A novel Drosophila model for neurodevelopmental disorders associated with Shwachman-Diamond syndrome2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Novel genetic link between the ATP-binding cassette subfamily A gene and hippo gene in Drosophila.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Investigating Developmental and Epileptic Encephalopathy Using Drosophila melanogaster2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Identification of novel BCL11A variants in patients with epileptic encephalopathy: Expanding the phenotypic spectrum2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Luteolin attenuates interleukin-6-mediated astrogliosis in human iPSC-derived neural aggregates: A candidate preventive substance for maternal immune activation-induced abnormalities2017

Author(s)

Journal Title

Chiyonobu Tomohiro 千代延友裕

CHIYONOBU Tomohiro 千代延友裕