SEKIYAMA Kazunari 関山一成

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関山一成セキヤマカズナリ

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Researcher Number	40572764
Other IDs
Affiliation (Current)	2025: 公益財団法人東京都医学総合研究所, 認知症・高次脳機能研究分野, 主任研究員
Affiliation (based on the past Project Information) *help	2015: 公益財団法人東京都医学総合研究所, 認知症・高次脳機能研究分野, 主任研究員 2013 – 2014: 公益財団法人東京都医学総合研究所, 運動・感覚システム研究分野, 研究員
Review Section/Research Field	Principal Investigator Nerve anatomy/Neuropathology
Keywords	Principal Investigator 神経変性 / シヌクレイン / トランスジェニックマウス / α-シヌクレイン / アディポネクチン / シヌクレイノパチー / 神経変性疾患

Adiponectin, anti diabetic adipokine, as a novel therapeutic strategy for synucleinopathies.Principal Investigator
- Principal Investigator
  
  SEKIYAMA Kazunari
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Tokyo Metropolitan Institute of Medical Science

All 2016 2015 2014 2013 Other

All Journal Article Presentation Book

[Book] Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging.2014
- Author(s)
  Takenouchi T, Sekiyama K Tsukimoto M, Iwamaru Y, Takato Takenouchi, Kazunari Sekiyama, Fujita M, Sugama S, Kitani H, Hashimoto M.
- Total Pages
  304
- Publisher
  Elsevier Science
- Data Source
  KAKENHI-PROJECT-25830044
[Journal Article] Insight into the dissociation of behavior from histology in Synucleinopathies and in related neurodegenerative diseases2016
- Author(s)
  Sekiyama K, Takamatsu Y, Koike W, Waragai M, Takenouchi T, Sugama S, Hashimoto M.
- Journal Title
  
  Journal of Alzheimer's Disease
  
  Volume: in press Issue: 3 Pages: 831-841
- DOI
  10.3233/jad-151015
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25640030, KAKENHI-PROJECT-25830044, KAKENHI-PROJECT-25290019, KAKENHI-PROJECT-26640033, KAKENHI-PROJECT-15K09820
[Journal Article] シヌクレイントランスジェニックマウス2015
- Author(s)
  関山一成, 橋本　款.
- Journal Title
  
  細胞
  
  Volume: Vol.47 No.1 Pages: 16-19
- Data Source
  KAKENHI-PROJECT-25830044
[Journal Article] Role of genomics in translational research for Parkinson's disease.2014
- Author(s)
  Sekiyama K, Takamatsu Y, Waragai M, Hashimoto M.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 452(2) Pages: 226-235
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25830044
[Journal Article] Disease-Modifying Effect of Adiponectin in Model of α-Synucleinopathie2014
- Author(s)
  Sekiyama K, Waragai M, Akatsu H, Sugama S, Takenouchi T, Takamatsu Y, Fujita M, Sekigawa A, Rockenstein E, Inoue S, La Spada A, Masliah E, Hashimoto M
- Journal Title
  
  Ann Clin Transl Neurol
  
  Volume: 1 Issue: 7 Pages: 479-489
- DOI
  10.1002/acn3.77
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23249040, KAKENHI-PROJECT-25640030, KAKENHI-PROJECT-25830044, KAKENHI-PROJECT-26640033
[Journal Article] Biomarkers for the diagnosis and management of Parkinson’s disease.2013
- Author(s)
  Waragai M, Sekiyama K, Fujita M, Tokuda T, *Hashimoto M.
- Journal Title
  
  Exp. Opi. Med. Diag.
  
  Volume: 1 Pages: 71-83
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25830044
[Journal Article] Diversity of mitochondrial pathology in a mouse model of axonal degeneration in synucleinopathies2013
- Author(s)
  Sekigawa A
- Journal Title
  
  Oxid Med Cell Longev.
  
  Volume: 2013 Pages: 817807-817807
- DOI
  10.1155/2013/817807
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659462, KAKENHI-PUBLICLY-24111555, KAKENHI-PROJECT-25290019, KAKENHI-PROJECT-25640030, KAKENHI-PROJECT-25830044
[Journal Article] Dual effects of βsynuclein in the pathogenesis of Parkinson's disease2013
- Author(s)
  Akio Sekigawa, Kazunari Sekiyama, Masayo Fujita, Yoshiki Takamatsu, Albert R. La Spada, Elizer Masliah, Makoto Hashimoto
- Journal Title
  
  Annals of Neurology
  
  Volume: 7 Issue: 2 Pages: 306-306
- DOI
  10.1002/ana.23936
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-24111555, KAKENHI-PROJECT-25290019, KAKENHI-PROJECT-25830044
[Presentation] Adiponectin, the anti-diabetic adipokine, has a therapeutic effect in models of α-synucleinopathies.2015
- Author(s)
  Sekiyama K, Waragai M, Takamatsu Y, Hashimoto M.
- Organizer
  ADPD 2015
- Place of Presentation
  フランス、ニース、アクロポリス国際会議場
- Year and Date
  2015-03-21
- Data Source
  KAKENHI-PROJECT-25830044
[Presentation] Role of APPL-1, in adiponectin/insulin-mediated protection against neurodegeneration in a cellular model of α-synucleinopathies.2015
- Author(s)
  Kazunari Sekiyama, Waragai Masaaki, Yoshiki Takamatsu, Makoto Hashimoto.
- Organizer
  第38回日本神経科学大会
- Place of Presentation
  神戸ポートアイランド　兵庫県神戸市
- Year and Date
  2015-07-30
- Data Source
  KAKENHI-PROJECT-25830044
[Presentation] アディポネクチンはα-シヌクレイノパチー細胞モデルのインスリンシグナルを亢進し神経変性の病態を改善する。2014
- Author(s)
  関山一成，高松芳樹，橋本款
- Organizer
  第３７回日本神経科学大会
- Place of Presentation
  パシフィコ横浜　神奈川県横浜市
- Year and Date
  2014-09-13
- Data Source
  KAKENHI-PROJECT-25830044
[Presentation] レビー小体型認知症で見出された変異型βシヌクレインを発現するショウジョウバエは神経変性様表現型を示す。2014
- Author(s)
  高松芳樹、関山一成、本多芳子、児玉亨、橋本款
- Organizer
  第３７回日本神経科学大会
- Place of Presentation
  パシフィコ横浜　神奈川県横浜市
- Year and Date
  2014-09-11
- Data Source
  KAKENHI-PROJECT-25830044
[Presentation] レビー小体型認知症で同定された変異型β シヌクレイン(P123H, V70M) を導入したショウジョウバエの解析.
- Author(s)
  高松芳樹，関川明生，堀内純二郎，関山一成，藤田雅代，児玉亨，齋藤実，橋本款.
- Organizer
  第３６回日本分子生物学会年会
- Place of Presentation
  神戸ポートアイランド
- Data Source
  KAKENHI-PROJECT-25830044
[Presentation] The anti-diabetic hormone, adiponectin, has protective effect on the pathogenesis of in vitro and in vivo models of α-synucleinopathies.
- Author(s)
  Sekiyama K, Fujita M, Sekigawa A, Takamatsu Y, Hashimoto M
- Organizer
  Neuroscinence 2013
- Place of Presentation
  San Diego, 米国
- Data Source
  KAKENHI-PROJECT-25830044
[Presentation] シヌクレイノパチー病態におけるアディポネクチンの治療効果について.
- Author(s)
  関山一成, 藤田雅代, 高松芳樹, 橋本款.
- Organizer
  第３６回日本分子生物学会年会
- Place of Presentation
  神戸ポートアイランド
- Data Source
  KAKENHI-PROJECT-25830044

1. 橋本款

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
2. 井上聰

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

SEKIYAMA Kazunari 関山 一成

関山 一成 セキヤマ カズナリ

Research Projects

Research Products

Co-Researchers

Adiponectin, anti diabetic adipokine, as a novel therapeutic strategy for synucleinopathies.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging.2014

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Insight into the dissociation of behavior from histology in Synucleinopathies and in related neurodegenerative diseases2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] シヌクレイントランスジェニックマウス2015

Author(s)

Journal Title

Data Source

[Journal Article] Role of genomics in translational research for Parkinson's disease.2014

Author(s)

Journal Title

Data Source

[Journal Article] Disease-Modifying Effect of Adiponectin in Model of α-Synucleinopathie2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Biomarkers for the diagnosis and management of Parkinson’s disease.2013

Author(s)

Journal Title

Data Source

[Journal Article] Diversity of mitochondrial pathology in a mouse model of axonal degeneration in synucleinopathies2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Dual effects of βsynuclein in the pathogenesis of Parkinson's disease2013

Author(s)

Journal Title

DOI

Data Source

[Presentation] Adiponectin, the anti-diabetic adipokine, has a therapeutic effect in models of α-synucleinopathies.2015

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Role of APPL-1, in adiponectin/insulin-mediated protection against neurodegeneration in a cellular model of α-synucleinopathies.2015

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] アディポネクチンはα-シヌクレイノパチー細胞モデルのインスリンシグナルを亢進し神経変性の病態を改善する。2014

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] レビー小体型認知症で見出された変異型βシヌクレインを発現するショウジョウバエは神経変性様表現型を示す。2014

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] レビー小体型認知症で同定された変異型β シヌクレイン(P123H, V70M) を導入したショウジョウバエの解析.

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] The anti-diabetic hormone, adiponectin, has protective effect on the pathogenesis of in vitro and in vivo models of α-synucleinopathies.

Author(s)

Organizer

SEKIYAMA Kazunari 関山一成

関山一成セキヤマカズナリ