Ishizu Hirotsugu 石津大嗣

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ISHIZU Hirotsugu 石津大嗣

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Researcher Number	40574588
Other IDs
Affiliation (Current)	2025: 慶應義塾大学, 医学部(信濃町), 講師
Affiliation (based on the past Project Information) *help	2019 – 2023: 慶應義塾大学, 医学部(信濃町), 講師 2018: 慶應義塾大学, 医学部(信濃町), 助教 2017: 慶應義塾大学, 医学部, 助教 2016 – 2017: 東京大学, 大学院理学系研究科(理学部), 助教 2013 – 2015: 東京大学, 理学(系)研究科(研究院), 助教
Review Section/Research Field	Principal Investigator Molecular biology / Biological Sciences / Basic Section 43010:Molecular biology-related Except Principal Investigator Basic Section 43010:Molecular biology-related / Molecular biology
Keywords	Principal Investigator piRNA / RNAサイレンシング / Piwi / レトロトランスポゾン / 翻訳 / RNA silencing / non-coding RNA / MACS / TSC / シングルセルRNA-seq … More / ブラストイド / MERVL / 全能性 / RNA helicase / iCLIP / Armitage / Yb / CLIPPARE / GasZ / Zuc / Armi / 定量プロテオーム解析 / RNA顆粒体 / プロテオーム / APEX / RNA granule / Yb body / 3'UTR / 翻訳制御 / 生殖細胞 / エピゲノム制御 / CRISPR-Cas9 / RNA二次構造 / tj / CRISPR … More Except Principal Investigator 病原性 / ファージ / DNAサイレンシング / プラスミド / DNA複製阻害 / シンバイオシス / 小分子RNA / DNA silencing / Argonaute / small RNA / ショウジョウバエ / RNAサイレンシング / トランスポゾン / piRNA / PIWI Less

全能性幹細胞におけるレトロトランスポゾンMERVLの核内RNA機能解析Principal Investigator
- Principal Investigator
  
  石津大嗣
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43010:Molecular biology-related
- Research Institution
  Keio University
Association between acquisition of virulence factors and Argonaute protein in bacteria
- Principal Investigator
  
  Miyoshi Tomohiro
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43010:Molecular biology-related
- Research Institution
  Matsumoto Dental University
Analysis of piRNA biogenesis pathwayPrincipal Investigator
- Principal Investigator
  
  ISHIZU Hirotsugu
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Molecular biology
- Research Institution
  Keio University
  The University of Tokyo
piRNA生合成経路による翻訳制御機構Principal Investigator
- Principal Investigator
  
  石津大嗣
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Proteomic mapping of Yb body in live OSCs via APEX taggingPrincipal Investigator
- Principal Investigator
  
  Ishizu Hirotsugu
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Molecular biology
- Research Institution
  The University of Tokyo
Elucidation of molecular mechanisms of the primary piRNA pathwayPrincipal Investigator
- Principal Investigator
  
  Ishizu Hirotsugu
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Molecular biology
- Research Institution
  The University of Tokyo
piRNAによる染色体構造制御機構の解析Principal Investigator
- Principal Investigator
  
  石津大嗣
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Elucidation of the piRNA pathway and development of novel gene knock-down methodPrincipal Investigator
- Principal Investigator
  
  ISHIZU Hirotsugu
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Molecular biology
- Research Institution
  The University of Tokyo
Elucidation of molecular mechanisms of how piRNAs maintain the germline genome integrity from invasive mobile elements
- Principal Investigator
  
  Siomi Mikiko
- Project Period (FY)
  2013 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Molecular biology
- Research Institution
  The University of Tokyo

All 2023 2022 2019 2018 2017 2016 2015 2014 2013 Other

All Journal Article Presentation

[Journal Article] Transcription of MERVL retrotransposons is required for preimplantation embryo development2023
- Author(s)
  Sakashita Akihiko、Kitano Tomohiro、Ishizu Hirotsugu、Guo Youjia、Masuda Harumi、Ariura Masaru、Murano Kensaku、Siomi Haruhiko
- Journal Title
  
  Nature Genetics
  
  Volume: 55 Issue: 3 Pages: 484-495
- DOI
  10.1038/s41588-023-01324-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06091, KAKENHI-ORGANIZER-19H05749, KAKENHI-PUBLICLY-22H04700, KAKENHI-PLANNED-19H05753, KAKENHI-PROJECT-23K27370
[Journal Article] T-hairpin structure found in the RNA element involved in piRNA biogenesis2022
- Author(s)
  Takase Naomi、Otsu Maina、Hirakata Shigeki、Ishizu Hirotsugu、Siomi Mikiko C.、Kawai Gota
- Journal Title
  
  RNA
  
  Volume: 28 Issue: 4 Pages: 541-550
- DOI
  10.1261/rna.078967.121
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K15743, KAKENHI-PROJECT-22K06091, KAKENHI-PROJECT-19H05466
[Journal Article] Pro108Ser mutation of SARS-CoV-2 3CLpro reduces the enzyme activity and ameliorates the clinical severity of COVID-192022
- Author(s)
  Abe K, Kabe Y, Uchiyama S, Iwasaki YW, Ishizu H, Uwamino Y, Takenouchi T, Uno S, Ishii M, Maruno T, Noda M, Murata M, Hasegawa N, Saya H, Kitagawa Y, Fukunaga K, Amagai M, Siomi H, Suematsu M, Kosaki K, Keio Donner Project.
- Journal Title
  
  Sci Rep
  
  Volume: 12 Issue: 1 Pages: 1299-1299
- DOI
  10.1038/s41598-022-05424-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-19H05753, KAKENHI-PROJECT-21K06845, KAKENHI-PROJECT-22K06091
[Journal Article] Nuclear RNA export factor variant initiates piRNA-guided co-transcriptional silencing2019
- Author(s)
  Murano, K., Iwasaki Y.W., Ishizu H., Mashiko, A., Shibuya, A., Kondo, S., Adachi, S., Suzuki, S., Saito, K., Natsume, T., Siomi, M.C., Siomi, H.
- Journal Title
  
  The EMBO Journal
  
  Volume: 印刷中 Issue: 17 Pages: 1-20
- DOI
  10.15252/embj.2019102870
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-17H05603, KAKENHI-PROJECT-19H05466, KAKENHI-PUBLICLY-19H05268, KAKENHI-PLANNED-19H05753, KAKENHI-PROJECT-17H03632, KAKENHI-PROJECT-18H02379, KAKENHI-PROJECT-18H02421, KAKENHI-PROJECT-17K08644, KAKENHI-PROJECT-16H06276
[Journal Article] Distinct and collaborative functions of Yb and Armitage in transposon-targeting piRNA biogenesis2019
- Author(s)
  Ishizu, H., Kinoshita, T., Hirakata, S., Komatsuzaki, C., Siomi, M. C.
- Journal Title
  
  Cell Reports
  
  Volume: 印刷中
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H03632
[Journal Article] Requirements for multivalent Yb body assembly in transposon silencing in Drosophila2019
- Author(s)
  Shigeki Hirakata, Hirotsugu Ishizu, Aoi Fujita, Yumiko Tomoe, Mikiko C. Siomi
- Journal Title
  
  EMBO Reports
  
  Volume: 印刷中 Issue: 7
- DOI
  10.15252/embr.201947708
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17J04219, KAKENHI-PROJECT-19H05466, KAKENHI-PROJECT-17H06111, KAKENHI-PROJECT-17H03632, KAKENHI-PROJECT-16H06276
[Journal Article] Armitage determines PiwiーpiRISC processing from precursor formation and quality control to inter‐organelle translocation2019
- Author(s)
  Yamashiro Haruna、Negishi Mayu、Kinoshita Tatsuki、Ishizu Hirotsugu、Ohtani Hitoshi、Siomi Mikiko C
- Journal Title
  
  EMBO reports
  
  Volume: 21 Issue: 2
- DOI
  10.15252/embr.201948769
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H05466, KAKENHI-PROJECT-17H03632, KAKENHI-PROJECT-18J13628, KAKENHI-PROJECT-16H06276
[Journal Article] Distinct and collaborative functions of Yb and Armitage in transposon-targeting piRNA biogenesis2019
- Author(s)
  Hirotsugu Ishizu, Tatsuki Kinoshita, Shigeki Hirakata, Chihiro Komatsuzaki, and Mikiko C. Siomi
- Journal Title
  
  Cell Reports
  
  Volume: 27 Issue: 6 Pages: 1822-1835
- DOI
  10.1016/j.celrep.2019.04.029
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-26113004, KAKENHI-PROJECT-17H06111, KAKENHI-PROJECT-19H05466, KAKENHI-PROJECT-17H03632, KAKENHI-PROJECT-16H06276
[Journal Article] The nucleolar transcriptome regulates Piwi shuttling between the nucleolus and the nucleoplasm2018
- Author(s)
  Mikhaleva, E. A., Leinsoo, T.A., Ishizu, H., Gvozdev, V. A., Klenov, M.S.
- Journal Title
  
  Chromosome Research
  
  Volume: 27 Issue: 1-2 Pages: 141-152
- DOI
  10.1007/s10577-018-9595-y
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03632
[Journal Article] Use of the CRISPR-Cas9 system for genome editing in cultured Drosophila ovarian somatic cells.2017
- Author(s)
  Ishizu H, Sumiyoshi T, Siomi MC
- Journal Title
  
  Methods
  
  Volume: 126 Pages: 186-192
- DOI
  10.1016/j.ymeth.2017.05.021
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-16H01214, KAKENHI-ORGANIZER-25112001, KAKENHI-PROJECT-17H06111, KAKENHI-PROJECT-17H03632, KAKENHI-PROJECT-16K14666
[Journal Article] Production of Small Non-coding RNAs from the flamenco Locus Is Regulated by the gypsy Retrotransposon of Drosophila melanogaster.2016
- Author(s)
  Guida V, Cernilogar FM, Filograna A, De Gregorio R, Ishizu H, Siomi MC, Schotta G, Bellenchi GC, Andrenacci D.
- Journal Title
  
  Genetics
  
  Volume: 204（2） Pages: 631-644
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25221101
[Journal Article] Piwi Modulates Chromatin Accessibility by Regulating Multiple Factors Including Histone H1 to Repress Transposons.2016
- Author(s)
  Iwasaki YW, Murano K, Ishizu H, Shibuya A, Iyoda Y, Siomi MC, Siomi H, Saito K.
- Journal Title
  
  Molecular Cell
  
  Volume: 63 Issue: 3 Pages: 408-419
- DOI
  10.1016/j.molcel.2016.06.008
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-16H01214, KAKENHI-PLANNED-25112005, KAKENHI-PROJECT-25221003, KAKENHI-PROJECT-15H05585, KAKENHI-PROJECT-16K14666, KAKENHI-ORGANIZER-25112001
[Journal Article] Production of Small Noncoding RNAs from the flamenco Locus Is Regulated by the gypsy Retrotransposon of Drosophila melanogaster.2016
- Author(s)
  Guida V, Cernilogar FM, Filograna A, De Gregorio R, Ishizu H, Siomi MC, Schotta G, Bellenchi GC, Andrenacci D.
- Journal Title
  
  Genetics
  
  Volume: 204 Issue: 2 Pages: 631-644
- DOI
  10.1534/genetics.116.187922
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-16H01214, KAKENHI-PROJECT-15H05585, KAKENHI-PROJECT-16K14666
[Journal Article] Piwi Modulates Chromatin Accessibility by Regulating Multiple Factors Including Histone H1 to Repress Transposons2016
- Author(s)
  Iwasaki YW, Murano K, Ishizu H, Shibuya A, Iyoda Y, Siomi MC, Siomi H, Saito K.
- Journal Title
  
  Molecular Cell
  
  Volume: 63 Pages: 1-12
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25221101
[Journal Article] Krimper Enforces an Antisense Bias on piRNA Pools by Binding AGO3 in the Drosophila Germline2015
- Author(s)
  Sato K, Iwasaki YW (equal contribution), Shibuya A, Carninci P, Tsuchizawa Y, Ishizu H, Siomi MC, Siomi H
- Journal Title
  
  Molecular Cell
  
  Volume: 59 Issue: 4 Pages: 553-563
- DOI
  10.1016/j.molcel.2015.06.024
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01473, KAKENHI-PROJECT-25221003, KAKENHI-PROJECT-25221101, KAKENHI-PROJECT-15H05583, KAKENHI-PROJECT-15H05585, KAKENHI-PROJECT-26870112
[Journal Article] Somatic Primary piRNA Biogenesis Driven by cis-Acting RNA Elements and trans-Acting Yb2015
- Author(s)
  Ishizu H, Iwasaki YW, Hirakata S, Ozaki H, Iwasaki W, Siomi H, Siomi MC
- Journal Title
  
  Cell Reports
  
  Volume: 12 Issue: 3 Pages: 429-440
- DOI
  10.1016/j.celrep.2015.06.035
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PUBLICLY-15H01473, KAKENHI-PROJECT-221S0002, KAKENHI-PLANNED-26113004, KAKENHI-PROJECT-25221003, KAKENHI-PROJECT-25221101, KAKENHI-PROJECT-15H05583, KAKENHI-PROJECT-15H05585, KAKENHI-ORGANIZER-26113001
[Journal Article] Yb Integrates piRNA Intermediates and Processing Factors into Perinuclear Bodies to Enhance piRISC Assembly.2014
- Author(s)
  Murota Y, Ishizu H, Nakagawa S, Iwasaki YW, Shibata S, Kamatani MK, Saito K, Okano H, Siomi H, Siomi MC.
- Journal Title
  
  Cell Rep.
  
  Volume: 8 Issue: 1 Pages: 103-113
- DOI
  10.1016/j.celrep.2014.05.043
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24500447, KAKENHI-ORGANIZER-25112001, KAKENHI-PLANNED-25112005, KAKENHI-PUBLICLY-25125704, KAKENHI-PROJECT-25221003, KAKENHI-PROJECT-25221101, KAKENHI-PROJECT-25830134, KAKENHI-PROJECT-25840004, KAKENHI-PLANNED-26113004, KAKENHI-PLANNED-26113005, KAKENHI-PROJECT-26711006, KAKENHI-PLANNED-26117007
[Presentation] マウスES細胞の全能性リプログラミング機構の解明2023
- Author(s)
  石津大嗣
- Organizer
  第46回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-22K06091
[Presentation] Transient MERVL expression regulates the totipotent 2C-like state in murine embryonic stem cells2022
- Author(s)
  Hirotsugu Ishizu
- Organizer
  第45回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-22K06091
[Presentation] ショウジョウバエ卵巣体細胞における一次piRNA整合性経路の解析2019
- Author(s)
  石津大嗣、塩見春彦、塩見美喜子
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17H03632
[Presentation] Role of the RNA hilicase, Armitage, in the primary piRNA biogenesis pathway2019
- Author(s)
  Hirotsugu Ishizu
- Organizer
  Keystone Symposia, Small Regulatory RNAs
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03632
[Presentation] Role of the RNA helicase, Armitage, in the primary piRNA biogenesis pathway2019
- Author(s)
  Hirotsugu Ishizu, Tatsuki Kinoshita, MIkiko C. Siomi
- Organizer
  Keystone symposia, Small Regulatory RNAs
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03632
[Presentation] 一次piRNA生合成経路におけるRNAヘリカーゼArmitageの機能2018
- Author(s)
  石津大嗣
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17H03632
[Presentation] Role of the RNA helicase, Armitage, in the primary piRNA biogenesis pathway2017
- Author(s)
  Ishizu, H., Kinoshita, T., Siomi, MC
- Organizer
  The 43rd Naito Conference on “NoncodingRNA: Biology, Chemistry, & Diseases”
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03632
[Presentation] Role of the RNA helicase, Armitage, in the primary piRNA biogenesis pathway2017
- Author(s)
  Ishizu, H., Kinoshita, T., Siomi, MC
- Organizer
  The 43rd Naito Conference on “NoncodingRNA: Biology, Chemistry, & Diseases”
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-16H01214
[Presentation] piRNA生合成経路によるmRNA分解制御2017
- Author(s)
  石津大嗣、塩見美喜子
- Organizer
  第19回日本RNA学会年会
- Data Source
  KAKENHI-PUBLICLY-16H01214
[Presentation] piRNA生合成経路によるmRNA分解制御2017
- Author(s)
  石津大嗣、塩見美喜子
- Organizer
  第19回日本RNA学会年会
- Data Source
  KAKENHI-PROJECT-16K14666
[Presentation] Role of the RNA helicase, Armitage, in the primary piRNA biogenesis pathway2017
- Author(s)
  Ishizu, H., Kinoshita, T., Siomi, MC
- Organizer
  The 43rd Naito Conference on “NoncodingRNA: Biology, Chemistry, & Diseases”
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K14666
[Presentation] piRNA生合成経路によるmRNA分解制御2017
- Author(s)
  石津大嗣、塩見美喜子
- Organizer
  第19回日本RNA学会年会
- Data Source
  KAKENHI-PROJECT-17H03632
[Presentation] piRNA生合成過程における中間体RNAの解析2016
- Author(s)
  荒川耕平,石津大嗣,塩見美喜子
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-25221101
[Presentation] Role of the RNA helicase, Armitage, in the primary piRNA biogenesis pathway2016
- Author(s)
  Ishizu, H., Kinoshita, T., Siomi, MC.
- Organizer
  The 2016 joint annual meeting of the RNA Society and the RNA Society of Japan,
- Place of Presentation
  国立京都国際会館（京都府京都市左京区）
- Year and Date
  2016-06-28
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K14666
[Presentation] Analysis of mitochondrial piRNA factors in Drosophila ovarian cells2016
- Author(s)
  Haruna Yamashiro, Horoki Kawamura, Hirotsugu Ishizu, and Mikiko C. Siomi
- Organizer
  RNA2016
- Place of Presentation
  国立京都国際会館（京都府京都市）
- Year and Date
  2016-05-28
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221101
[Presentation] Role of the RNA helicase, Armitage, in the primary piRNA biogenesis pathway2016
- Author(s)
  Ishizu, H., Kinoshita, T., Siomi, MC.
- Organizer
  The 2016 joint annual meeting of the RNA Society and the RNA Society of Japan
- Place of Presentation
  国立京都国際会館（京都府京都市左京区）
- Year and Date
  2016-06-28
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-16H01214
[Presentation] Role of the RNA helicase, Armitage, in the primary piRNA biogenesis pathway2016
- Author(s)
  Ishizu, H., Kinoshita, T., Siomi, MC.
- Organizer
  The 2016 joint annual meeting of the RNA Society and the RNA Society of Japan
- Place of Presentation
  国立京都国際会館（京都府京都市左京区）
- Year and Date
  2016-06-28
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05585
[Presentation] Genic piRNA biogenesis in Drosophila Ovarian Somatic Cells; its molecular mechanism and meaning2016
- Author(s)
  Kohei Arakawa, Hirotsugu Ishizu, Mikiko C Siomi
- Organizer
  CSHA conference on RNA Biology
- Place of Presentation
  蘇州市（中国）
- Year and Date
  2016-11-14
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221101
[Presentation] Elucidation of the primary piRNA pathway in Drosophila ovarian somatic cells2015
- Author(s)
  Hirotsugu Ishizu.
- Organizer
  EMBO/EMBL Symposia
- Place of Presentation
  Heidelberg（Germany）
- Year and Date
  2015-10-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221101
[Presentation] 人工piRNA発現システムを用いたpiRNA生合成機構の解析2015
- Author(s)
  石津大嗣
- Organizer
  第17回日本RNA学会年会
- Place of Presentation
  ホテルライフォート札幌（北海道・札幌市）
- Year and Date
  2015-07-16
- Data Source
  KAKENHI-PROJECT-25221101
[Presentation] Elucidation of the primary piRNA pathway in Drosophila ovarian somatic cells2015
- Author(s)
  Ishizu, H., Siomi, H., Siomi, MC.
- Organizer
  EMBO | EMBL Symposium: The Non-coding Genome
- Place of Presentation
  EMBL Advanced Training Centre (Germany・Heidelberg)
- Year and Date
  2015-10-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05585
[Presentation] piRNA生合成における前駆体RNA認識機構の解析2015
- Author(s)
  石津大嗣
- Organizer
  NGS現場の会第四回研究会
- Place of Presentation
  つくば国際会議場（茨城県・つくば市）
- Year and Date
  2015-07-01
- Invited
- Data Source
  KAKENHI-PROJECT-15H05585
[Presentation] 人工piRNA発現システムを用いたpiRNA生合成機構の解析2014
- Author(s)
  石津　大嗣、岩崎　由香、平形　樹生、福永　津嵩、尾崎　遼、木立　尚孝、岩崎　渉、塩見　春彦、塩見　美喜子
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2014-11-26
- Data Source
  KAKENHI-PUBLICLY-25125704
[Presentation] 人工piRNA発現システムを用いたpiRNA生合成機構の解析2014
- Author(s)
  石津　大嗣、平形　樹生、福永　津嵩、尾崎　遼、木立　尚孝、岩崎　渉、塩見　春彦、塩見　美喜子
- Organizer
  第16回日本RNA学会年会
- Place of Presentation
  ウインクあいち（愛知県名古屋市）
- Year and Date
  2014-07-23
- Data Source
  KAKENHI-PROJECT-25840004
[Presentation] 人工piRNA発現システムを用いたpiRNA生合成機構の解析2014
- Author(s)
  石津　大嗣、平形　樹生、福永　津嵩、尾崎　遼、木立　尚孝、岩崎　渉、塩見　春彦、塩見　美喜子
- Organizer
  第16回日本RNA学会年会
- Place of Presentation
  ウインクあいち（愛知県名古屋市）
- Year and Date
  2014-07-23
- Data Source
  KAKENHI-PUBLICLY-25125704
[Presentation] 人工piRNA発現システムを用いたpiRNA生合成機構の解析2014
- Author(s)
  石津　大嗣、岩崎　由香、平形　樹生、福永　津嵩、尾崎　遼、木立　尚孝、岩崎　渉、塩見　春彦、塩見　美喜子
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2014-11-26
- Data Source
  KAKENHI-PROJECT-25840004
[Presentation] 人工piRNA発現システムを用いたRNAサイレンシング機構の解析2013
- Author(s)
  石津大嗣
- Organizer
  第１５回日本RNA学会年会
- Place of Presentation
  ひめぎんホール (愛媛県)
- Invited
- Data Source
  KAKENHI-PROJECT-25840004
[Presentation] 人工piRNA発現システムを用いたRNAサイレンシング機構の解析2013
- Author(s)
  石津大嗣
- Organizer
  第１５回日本RNA学会年会
- Place of Presentation
  ひめぎんホール（愛媛県）
- Invited
- Data Source
  KAKENHI-PUBLICLY-25125704
[Presentation] primary piRNA生合成に働くcis-elementの探索
- Author(s)
  平形樹生、石津大嗣、塩見美喜子
- Organizer
  第16回日本RNA学会年会
- Place of Presentation
  ウインクあいち（名古屋市）
- Year and Date
  2014-07-23 – 2014-07-25
- Data Source
  KAKENHI-PROJECT-25221101
[Presentation] YbによるpiRNA生合成因子／piRNA前駆体の制御機構
- Author(s)
  室田友紀子、石津大嗣、中川真一、岩崎由香、芝田晋介、鎌谷太陽、齋藤都暁、岡野栄之、塩見春彦、塩見美喜子
- Organizer
  第16回日本RNA学会年会
- Place of Presentation
  ウインクあいち（名古屋市）
- Year and Date
  2014-07-23 – 2014-07-25
- Data Source
  KAKENHI-PROJECT-25221101
[Presentation] Yb integrates piRNA intermediates and processing factors into perinuclear bodies to enhance piRISC assembly
- Author(s)
  Yukiko Murota, Hirotsugu Ishizu, Shinichi Nakagawa, Yuka W. Iwasaki, Shinsuke Shibata, Miharu K. Kamatani, Kuniaki Saito, Hideyuki Okano, Haruhiko Siomi and Mikiko C. Siomi
- Organizer
  JAJRNA Meeting 2014
- Place of Presentation
  University of Technology Sydney（オーストラリア）
- Year and Date
  2014-11-01 – 2014-11-06
- Data Source
  KAKENHI-PROJECT-25221101

1. Siomi Mikiko (20322745)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
2. Miyoshi Tomohiro (60534550)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 岩崎由香

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
4. 平形樹生

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 塩見春彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 芝田晋介

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 岡野栄之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Ishizu Hirotsugu 石津 大嗣

ISHIZU Hirotsugu 石津 大嗣

Research Projects

Research Products

Co-Researchers

全能性幹細胞におけるレトロトランスポゾンMERVLの核内RNA機能解析Principal Investigator

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Association between acquisition of virulence factors and Argonaute protein in bacteria

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Analysis of piRNA biogenesis pathwayPrincipal Investigator

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piRNA生合成経路による翻訳制御機構Principal Investigator

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Proteomic mapping of Yb body in live OSCs via APEX taggingPrincipal Investigator

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Elucidation of molecular mechanisms of the primary piRNA pathwayPrincipal Investigator

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piRNAによる染色体構造制御機構の解析Principal Investigator

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Elucidation of the piRNA pathway and development of novel gene knock-down methodPrincipal Investigator

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Elucidation of molecular mechanisms of how piRNAs maintain the germline genome integrity from invasive mobile elements

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[Journal Article] Transcription of MERVL retrotransposons is required for preimplantation embryo development2023

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[Journal Article] T-hairpin structure found in the RNA element involved in piRNA biogenesis2022

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[Journal Article] Pro108Ser mutation of SARS-CoV-2 3CLpro reduces the enzyme activity and ameliorates the clinical severity of COVID-192022

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[Journal Article] Nuclear RNA export factor variant initiates piRNA-guided co-transcriptional silencing2019

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[Journal Article] Distinct and collaborative functions of Yb and Armitage in transposon-targeting piRNA biogenesis2019

Ishizu Hirotsugu 石津大嗣

ISHIZU Hirotsugu 石津大嗣