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Ishizu Hirotsugu  石津 大嗣

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ISHIZU Hirotsugu  石津 大嗣

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Researcher Number 40574588
Affiliation (Current) 2019: 慶應義塾大学, 医学部(信濃町), 助教
Affiliation (based on the past Project Information) *help 2018 – 2019: 慶應義塾大学, 医学部(信濃町), 助教
2017: 慶應義塾大学, 医学部, 助教
2016 – 2017: 東京大学, 大学院理学系研究科(理学部), 助教
2013 – 2015: 東京大学, 理学(系)研究科(研究院), 助教
Review Section/Research Field
Principal Investigator
Molecular biology / Biological Sciences
Except Principal Investigator
Molecular biology / Basic Section 43010:Molecular biology-related
Keywords
Principal Investigator
piRNA / Piwi / RNAサイレンシング / RNA silencing / 翻訳 / CRISPR / tj / RNA二次構造 / CRISPR-Cas9 / エピゲノム制御 … More / 生殖細胞 / 翻訳制御 / 3'UTR / Yb body / RNA granule / APEX / プロテオーム / RNA顆粒体 / 定量プロテオーム解析 / Armi / Armitage / iCLIP / RNA helicase … More
Except Principal Investigator
PIWI / piRNA / トランスポゾン / RNAサイレンシング / ショウジョウバエ / Argonaute / 小分子RNA / DNAサイレンシング / ファージ / 病原性 Less
  • Research Projects

    (8 results)
  • Research Products

    (33 results)
  • Co-Researchers

    (14 People)
  •  Association between acquisition of virulence factors and Argonaute protein in bacteriaOngoing

    • Principal Investigator
      三好 智博
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 43010:Molecular biology-related
    • Research Institution
      Matsumoto Dental University
  •  Analysis of piRNA biogenesis pathwayPrincipal InvestigatorOngoing

    • Principal Investigator
      石津 大嗣
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Molecular biology
    • Research Institution
      Keio University
      The University of Tokyo
  •  piRNA生合成経路による翻訳制御機構Principal Investigator

    • Principal Investigator
      石津 大嗣
    • Project Period (FY)
      2016 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokyo
  •  Proteomic mapping of Yb body in live OSCs via APEX taggingPrincipal Investigator

    • Principal Investigator
      Ishizu Hirotsugu
    • Project Period (FY)
      2016 – 2017
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Molecular biology
    • Research Institution
      The University of Tokyo
  •  Elucidation of molecular mechanisms of the primary piRNA pathwayPrincipal Investigator

    • Principal Investigator
      Ishizu Hirotsugu
    • Project Period (FY)
      2015 – 2016
    • Research Category
      Grant-in-Aid for Young Scientists (A)
    • Research Field
      Molecular biology
    • Research Institution
      The University of Tokyo
  •  piRNAによる染色体構造制御機構の解析Principal Investigator

    • Principal Investigator
      石津 大嗣
    • Project Period (FY)
      2013 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokyo
  •  Elucidation of the piRNA pathway and development of novel gene knock-down methodPrincipal Investigator

    • Principal Investigator
      ISHIZU Hirotsugu
    • Project Period (FY)
      2013 – 2014
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Molecular biology
    • Research Institution
      The University of Tokyo
  •  Elucidation of molecular mechanisms of how piRNAs maintain the germline genome integrity from invasive mobile elements

    • Principal Investigator
      Siomi Mikiko
    • Project Period (FY)
      2013 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (S)
    • Research Field
      Molecular biology
    • Research Institution
      The University of Tokyo

All 2017 2016 2015 2014 2013 Other

All Journal Article Presentation

  • [Journal Article] Use of the CRISPR-Cas9 system for genome editing in cultured Drosophila ovarian somatic cells2017

    • Author(s)
      Ishizu H, Sumiyoshi T, Siomi MC
    • Journal Title

      ScienceDirect

      Volume: 126 Pages: 186-192

    • DOI
      10.1016/j.ymeth.2017.05.021
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PUBLICLY-16H01214, KAKENHI-ORGANIZER-25112001, KAKENHI-PROJECT-17H06111, KAKENHI-PROJECT-17H03632, KAKENHI-PROJECT-16K14666
  • [Journal Article] Production of Small Non-coding RNAs from the flamenco Locus Is Regulated by the gypsy Retrotransposon of Drosophila melanogaster.2016

    • Author(s)
      Miura, T., Yamana Y, Usui, T., Ogawa, H.I., Yamamoto, M.T., and Kusano, K.
    • Journal Title

      Cryptomeria japonica. Genetics

      Volume: 191 Pages: 45-48

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-ORGANIZER-21113001, KAKENHI-PROJECT-22370083, KAKENHI-PROJECT-24390053, KAKENHI-PLANNED-26113004, KAKENHI-PROJECT-25221101
  • [Journal Article] Piwi modulates chromatin accessibility by regulating multiple factors including histone H1 to repress transposons.2016

    • Author(s)
      Iwasaki YW, Murano K, Ishizu H, Shibuya A, Iyoda Y, Siomi MC, Siomi H, Saito K.
    • Journal Title

      Mol Cell.

      Volume: 63 Pages: 408-19

    • DOI
      10.1016/j.molcel.2016.06.008
    • Peer Reviewed / Open Access / Acknowledgement Compliant
    • Data Source
      KAKENHI-PUBLICLY-16H01214, KAKENHI-PLANNED-25112005, KAKENHI-PROJECT-25221003, KAKENHI-PROJECT-15H05585, KAKENHI-PROJECT-16K14666, KAKENHI-ORGANIZER-25112001
  • [Journal Article] Production of Small Noncoding RNAs from the flamenco Locus Is Regulated by the gypsy Retrotransposon of Drosophila melanogaster.2016

    • Author(s)
      Guida V, Cernilogar FM, Filograna A, De Gregorio R, Ishizu H, Siomi MC, Schotta G, Bellenchi GC, Andrenacci D.
    • Journal Title

      Genetics

      Volume: 204 Pages: 631-644

    • DOI
      10.1534/genetics.116.187922
    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-16H01214, KAKENHI-PROJECT-15H05585, KAKENHI-PROJECT-16K14666
  • [Journal Article] Piwi Modulates Chromatin Accessibility by Regulating Multiple Factors Including Histone H1 to Repress Transposons2016

    • Author(s)
      Ito C, Saito Y, Nozawa T, Fujii S, Sawa T, Inoue H, Matsunaga T, Khan S, Akashi S, Hashimoto R, Aikawa C, Takahashi E, Sagara H, Komatsu M, Tanaka K, Akaike T, Nakagawa I, Arimoto H.
    • Journal Title

      Molecular Cell

      Volume: 52 Pages: 1-12

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-25111006, KAKENHI-PROJECT-25221101
  • [Journal Article] Krimper Enforces an Antisense Bias on piRNA Pools by Binding AGO3 in the Drosophila Germline.2015

    • Author(s)
      Sato K, Iwasaki YW (equal contribution), Shibuya A, Carninci P, Tsuchizawa Y, Ishizu H, Siomi MC, Siomi H
    • Journal Title

      Moleular Cell

      Volume: 59 Pages: 553-563

    • DOI
      10.1016/j.molcel.2015.06.024
    • Peer Reviewed / Open Access / Acknowledgement Compliant / Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-15H01473, KAKENHI-PROJECT-25221003, KAKENHI-PROJECT-25221101, KAKENHI-PROJECT-15H05583, KAKENHI-PROJECT-15H05585, KAKENHI-PROJECT-26870112
  • [Journal Article] Somatic Primary piRNA Biogenesis Driven by cis-Acting RNA Elements and trans-Acting Yb.2015

    • Author(s)
      Ishizu H, Iwasaki YW, Hirakata S, Ozaki H, Iwasaki W, Siomi H, Siomi MC
    • Journal Title

      Cell Reports.

      Volume: 12 Pages: 429-40

    • DOI
      10.1016/j.celrep.2015.06.035
    • Peer Reviewed / Open Access / Acknowledgement Compliant
    • Data Source
      KAKENHI-PUBLICLY-15H01473, KAKENHI-PROJECT-221S0002, KAKENHI-PLANNED-26113004, KAKENHI-PROJECT-25221003, KAKENHI-PROJECT-25221101, KAKENHI-PROJECT-15H05583, KAKENHI-PROJECT-15H05585, KAKENHI-ORGANIZER-26113001
  • [Journal Article] Yb integrates piRNA intermediates and processing factors into perinuclear bodies to enhance piRISC assembly2014

    • Author(s)
      Murota Y, Ishizu H, Nakagawa S, Iwasaki YW, Shibata S, Kamatani MK, Saito K, Okano H, Siomi H, Siomi MC.
    • Journal Title

      Cell Rep

      Volume: 8 Pages: 103-113

    • DOI
      10.1016/j.celrep.2014.05.043
    • Peer Reviewed / Open Access / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-24500447, KAKENHI-ORGANIZER-25112001, KAKENHI-PLANNED-25112005, KAKENHI-PUBLICLY-25125704, KAKENHI-PROJECT-25221003, KAKENHI-PROJECT-25221101, KAKENHI-PROJECT-25830134, KAKENHI-PROJECT-25840004, KAKENHI-PLANNED-26113004, KAKENHI-PLANNED-26113005, KAKENHI-PROJECT-26711006, KAKENHI-PLANNED-26117007
  • [Presentation] Role of the RNA helicase, Armitage, in the primary piRNA biogenesis pathway2017

    • Author(s)
      Ishizu, H., Kinoshita, T., Siomi, MC
    • Organizer
      The 43rd Naito Conference on “NoncodingRNA: Biology, Chemistry, & Diseases”
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H03632
  • [Presentation] Role of the RNA helicase, Armitage, in the primary piRNA biogenesis pathway2017

    • Author(s)
      Ishizu, H., Kinoshita, T., Siomi, MC
    • Organizer
      The 43rd Naito Conference on “NoncodingRNA: Biology, Chemistry, & Diseases”
    • Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-16H01214
  • [Presentation] piRNA生合成経路によるmRNA分解制御2017

    • Author(s)
      石津大嗣、塩見美喜子
    • Organizer
      第19回日本RNA学会年会
    • Data Source
      KAKENHI-PUBLICLY-16H01214
  • [Presentation] piRNA生合成経路によるmRNA分解制御2017

    • Author(s)
      石津大嗣、塩見美喜子
    • Organizer
      第19回日本RNA学会年会
    • Data Source
      KAKENHI-PROJECT-16K14666
  • [Presentation] Role of the RNA helicase, Armitage, in the primary piRNA biogenesis pathway2017

    • Author(s)
      Ishizu, H., Kinoshita, T., Siomi, MC
    • Organizer
      The 43rd Naito Conference on “NoncodingRNA: Biology, Chemistry, & Diseases”
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K14666
  • [Presentation] piRNA生合成経路によるmRNA分解制御2017

    • Author(s)
      石津大嗣、塩見美喜子
    • Organizer
      第19回日本RNA学会年会
    • Data Source
      KAKENHI-PROJECT-17H03632
  • [Presentation] piRNA生合成過程における中間体RNAの解析2016

    • Author(s)
      荒川 耕平,石津 大嗣,塩見 美喜子
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県 横浜市)
    • Year and Date
      2016-11-30
    • Data Source
      KAKENHI-PROJECT-25221101
  • [Presentation] Role of the RNA helicase, Armitage, in the primary piRNA biogenesis pathway2016

    • Author(s)
      Ishizu, H., Kinoshita, T., Siomi, MC.
    • Organizer
      The 2016 joint annual meeting of the RNA Society and the RNA Society of Japan,
    • Place of Presentation
      国立京都国際会館(京都府京都市左京区)
    • Year and Date
      2016-06-28
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K14666
  • [Presentation] Analysis of mitochondrial piRNA factors in Drosophila ovarian cells2016

    • Author(s)
      Haruna Yamashiro, Horoki Kawamura, Hirotsugu Ishizu, and Mikiko C. Siomi
    • Organizer
      RNA2016
    • Place of Presentation
      国立京都国際会館(京都府 京都市)
    • Year and Date
      2016-05-28
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25221101
  • [Presentation] Role of the RNA helicase, Armitage, in the primary piRNA biogenesis pathway2016

    • Author(s)
      Ishizu, H., Kinoshita, T., Siomi, MC.
    • Organizer
      The 2016 joint annual meeting of the RNA Society and the RNA Society of Japan
    • Place of Presentation
      国立京都国際会館(京都府京都市左京区)
    • Year and Date
      2016-06-28
    • Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-16H01214
  • [Presentation] Role of the RNA helicase, Armitage, in the primary piRNA biogenesis pathway2016

    • Author(s)
      Ishizu, H., Kinoshita, T., Siomi, MC.
    • Organizer
      The 2016 joint annual meeting of the RNA Society and the RNA Society of Japan
    • Place of Presentation
      国立京都国際会館(京都府京都市左京区)
    • Year and Date
      2016-06-28
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H05585
  • [Presentation] Genic piRNA biogenesis in Drosophila Ovarian Somatic Cells; its molecular mechanism and meaning2016

    • Author(s)
      Kohei Arakawa, Hirotsugu Ishizu, Mikiko C Siomi
    • Organizer
      CSHA conference on RNA Biology
    • Place of Presentation
      蘇州市(中国)
    • Year and Date
      2016-11-14
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25221101
  • [Presentation] Elucidation of the primary piRNA pathway in Drosophila ovarian somatic cells2015

    • Author(s)
      Hirotsugu Ishizu.
    • Organizer
      EMBO/EMBL Symposia
    • Place of Presentation
      Heidelberg(Germany)
    • Year and Date
      2015-10-18
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25221101
  • [Presentation] 人工piRNA発現システムを用いたpiRNA生合成機構の解析2015

    • Author(s)
      石津大嗣
    • Organizer
      第17回日本RNA学会年会
    • Place of Presentation
      ホテルライフォート札幌(北海道・札幌市)
    • Year and Date
      2015-07-16
    • Data Source
      KAKENHI-PROJECT-25221101
  • [Presentation] Elucidation of the primary piRNA pathway in Drosophila ovarian somatic cells2015

    • Author(s)
      Ishizu, H., Siomi, H., Siomi, MC.
    • Organizer
      EMBO | EMBL Symposium: The Non-coding Genome
    • Place of Presentation
      EMBL Advanced Training Centre (Germany・Heidelberg)
    • Year and Date
      2015-10-18
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H05585
  • [Presentation] piRNA生合成における前駆体RNA認識機構の解析2015

    • Author(s)
      石津大嗣
    • Organizer
      NGS現場の会第四回研究会
    • Place of Presentation
      つくば国際会議場(茨城県・つくば市)
    • Year and Date
      2015-07-01
    • Invited
    • Data Source
      KAKENHI-PROJECT-15H05585
  • [Presentation] 人工piRNA発現システムを用いたpiRNA生合成機構の解析2014

    • Author(s)
      石津 大嗣、岩崎 由香、平形 樹生、福永 津嵩、尾崎 遼、木立 尚孝、岩崎 渉、塩見 春彦、塩見 美喜子
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2014-11-26
    • Data Source
      KAKENHI-PUBLICLY-25125704
  • [Presentation] 人工piRNA発現システムを用いたpiRNA生合成機構の解析2014

    • Author(s)
      石津 大嗣、平形 樹生、福永 津嵩、尾崎 遼、木立 尚孝、岩崎 渉、塩見 春彦、塩見 美喜子
    • Organizer
      第16回日本RNA学会年会
    • Place of Presentation
      ウインクあいち(愛知県名古屋市)
    • Year and Date
      2014-07-23
    • Data Source
      KAKENHI-PROJECT-25840004
  • [Presentation] 人工piRNA発現システムを用いたpiRNA生合成機構の解析2014

    • Author(s)
      石津 大嗣、平形 樹生、福永 津嵩、尾崎 遼、木立 尚孝、岩崎 渉、塩見 春彦、塩見 美喜子
    • Organizer
      第16回日本RNA学会年会
    • Place of Presentation
      ウインクあいち(愛知県名古屋市)
    • Year and Date
      2014-07-23
    • Data Source
      KAKENHI-PUBLICLY-25125704
  • [Presentation] 人工piRNA発現システムを用いたpiRNA生合成機構の解析2014

    • Author(s)
      石津 大嗣、岩崎 由香、平形 樹生、福永 津嵩、尾崎 遼、木立 尚孝、岩崎 渉、塩見 春彦、塩見 美喜子
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2014-11-26
    • Data Source
      KAKENHI-PROJECT-25840004
  • [Presentation] 人工piRNA発現システムを用いたRNAサイレンシング機構の解析2013

    • Author(s)
      石津大嗣
    • Organizer
      第15回日本RNA学会年会
    • Place of Presentation
      ひめぎんホール (愛媛県)
    • Invited
    • Data Source
      KAKENHI-PROJECT-25840004
  • [Presentation] 人工piRNA発現システムを用いたRNAサイレンシング機構の解析2013

    • Author(s)
      石津大嗣
    • Organizer
      第15回日本RNA学会年会
    • Place of Presentation
      ひめぎんホール(愛媛県)
    • Invited
    • Data Source
      KAKENHI-PUBLICLY-25125704
  • [Presentation] primary piRNA生合成に働くcis-elementの探索

    • Author(s)
      平形樹生、石津大嗣、塩見美喜子
    • Organizer
      第16回日本RNA学会年会
    • Place of Presentation
      ウインクあいち(名古屋市)
    • Year and Date
      2014-07-23 – 2014-07-25
    • Data Source
      KAKENHI-PROJECT-25221101
  • [Presentation] YbによるpiRNA生合成因子/piRNA前駆体の制御機構

    • Author(s)
      室田友紀子、石津大嗣、中川真一、岩崎由香、芝田晋介、鎌谷太陽、齋藤都暁、岡野栄之、塩見春彦、塩見美喜子
    • Organizer
      第16回日本RNA学会年会
    • Place of Presentation
      ウインクあいち(名古屋市)
    • Year and Date
      2014-07-23 – 2014-07-25
    • Data Source
      KAKENHI-PROJECT-25221101
  • [Presentation] Yb integrates piRNA intermediates and processing factors into perinuclear bodies to enhance piRISC assembly

    • Author(s)
      Yukiko Murota, Hirotsugu Ishizu, Shinichi Nakagawa, Yuka W. Iwasaki, Shinsuke Shibata, Miharu K. Kamatani, Kuniaki Saito, Hideyuki Okano, Haruhiko Siomi and Mikiko C. Siomi
    • Organizer
      JAJRNA Meeting 2014
    • Place of Presentation
      University of Technology Sydney(オーストラリア)
    • Year and Date
      2014-11-01 – 2014-11-06
    • Data Source
      KAKENHI-PROJECT-25221101
  • 1.  Siomi Mikiko (20322745)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 12 results
  • 2.  三好 智博 (60534550)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 3.  IWASAKI Yuka
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 7 results
  • 4.  SATO Kaoru
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 5.  MURANO Kensaku
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 6.  塩見 春彦
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 4 results
  • 7.  津村 義彦
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 8.  舘田 英典
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 9.  齋藤 都暁
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 10.  岩崎 渉
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 11.  小松 雅明
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 12.  芝田 晋介
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 13.  岡野 栄之
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 14.  中川 真一
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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