Ishizu Hirotsugu 石津大嗣

… Alternative Names

Researcher Number	40574588
Affiliation (Current)	2019: 慶應義塾大学, 医学部(信濃町), 助教
Affiliation (based on the past Project Information) *help	2018 – 2019: 慶應義塾大学, 医学部(信濃町), 助教 2017: 慶應義塾大学, 医学部, 助教 2016 – 2017: 東京大学, 大学院理学系研究科(理学部), 助教 2013 – 2015: 東京大学, 理学(系)研究科(研究院), 助教
Review Section/Research Field	Principal Investigator Molecular biology / Biological Sciences Except Principal Investigator Molecular biology / Basic Section 43010:Molecular biology-related
Keywords	Principal Investigator piRNA / Piwi / RNAサイレンシング / RNA silencing / 翻訳 / CRISPR / tj / RNA二次構造 / CRISPR-Cas9 / エピゲノム制御 … More Except Principal Investigator PIWI / piRNA / トランスポゾン / RNAサイレンシング / ショウジョウバエ / Argonaute / 小分子RNA / DNAサイレンシング / ファージ / 病原性 Less

Association between acquisition of virulence factors and Argonaute protein in bacteriaOngoing
- Principal Investigator
  
  三好智博
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43010:Molecular biology-related
- Research Institution
  Matsumoto Dental University
Analysis of piRNA biogenesis pathwayPrincipal InvestigatorOngoing
- Principal Investigator
  
  石津大嗣
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Molecular biology
- Research Institution
  Keio University
  The University of Tokyo
piRNA生合成経路による翻訳制御機構Principal Investigator
- Principal Investigator
  
  石津大嗣
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Proteomic mapping of Yb body in live OSCs via APEX taggingPrincipal Investigator
- Principal Investigator
  
  Ishizu Hirotsugu
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Molecular biology
- Research Institution
  The University of Tokyo
Elucidation of molecular mechanisms of the primary piRNA pathwayPrincipal Investigator
- Principal Investigator
  
  Ishizu Hirotsugu
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Molecular biology
- Research Institution
  The University of Tokyo
piRNAによる染色体構造制御機構の解析Principal Investigator
- Principal Investigator
  
  石津大嗣
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Elucidation of the piRNA pathway and development of novel gene knock-down methodPrincipal Investigator
- Principal Investigator
  
  ISHIZU Hirotsugu
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Molecular biology
- Research Institution
  The University of Tokyo
Elucidation of molecular mechanisms of how piRNAs maintain the germline genome integrity from invasive mobile elements
- Principal Investigator
  
  Siomi Mikiko
- Project Period (FY)
  2013 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Molecular biology
- Research Institution
  The University of Tokyo

All 2017 2016 2015 2014 2013 Other

All Journal Article Presentation

[Journal Article] Use of the CRISPR-Cas9 system for genome editing in cultured Drosophila ovarian somatic cells2017
- Author(s)
  Ishizu H, Sumiyoshi T, Siomi MC
- Journal Title
  
  ScienceDirect
  
  Volume: 126 Pages: 186-192
- DOI
  10.1016/j.ymeth.2017.05.021
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-16H01214, KAKENHI-ORGANIZER-25112001, KAKENHI-PROJECT-17H06111, KAKENHI-PROJECT-17H03632, KAKENHI-PROJECT-16K14666
[Journal Article] Production of Small Non-coding RNAs from the flamenco Locus Is Regulated by the gypsy Retrotransposon of Drosophila melanogaster.2016
- Author(s)
  Miura, T., Yamana Y, Usui, T., Ogawa, H.I., Yamamoto, M.T., and Kusano, K.
- Journal Title
  
  Cryptomeria japonica. Genetics
  
  Volume: 191 Pages: 45-48
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-ORGANIZER-21113001, KAKENHI-PROJECT-22370083, KAKENHI-PROJECT-24390053, KAKENHI-PLANNED-26113004, KAKENHI-PROJECT-25221101
[Journal Article] Piwi modulates chromatin accessibility by regulating multiple factors including histone H1 to repress transposons.2016
- Author(s)
  Iwasaki YW, Murano K, Ishizu H, Shibuya A, Iyoda Y, Siomi MC, Siomi H, Saito K.
- Journal Title
  
  Mol Cell.
  
  Volume: 63 Pages: 408-19
- DOI
  10.1016/j.molcel.2016.06.008
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PUBLICLY-16H01214, KAKENHI-PLANNED-25112005, KAKENHI-PROJECT-25221003, KAKENHI-PROJECT-15H05585, KAKENHI-PROJECT-16K14666, KAKENHI-ORGANIZER-25112001
[Journal Article] Production of Small Noncoding RNAs from the flamenco Locus Is Regulated by the gypsy Retrotransposon of Drosophila melanogaster.2016
- Author(s)
  Guida V, Cernilogar FM, Filograna A, De Gregorio R, Ishizu H, Siomi MC, Schotta G, Bellenchi GC, Andrenacci D.
- Journal Title
  
  Genetics
  
  Volume: 204 Pages: 631-644
- DOI
  10.1534/genetics.116.187922
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-16H01214, KAKENHI-PROJECT-15H05585, KAKENHI-PROJECT-16K14666
[Journal Article] Piwi Modulates Chromatin Accessibility by Regulating Multiple Factors Including Histone H1 to Repress Transposons2016
- Author(s)
  Ito C, Saito Y, Nozawa T, Fujii S, Sawa T, Inoue H, Matsunaga T, Khan S, Akashi S, Hashimoto R, Aikawa C, Takahashi E, Sagara H, Komatsu M, Tanaka K, Akaike T, Nakagawa I, Arimoto H.
- Journal Title
  
  Molecular Cell
  
  Volume: 52 Pages: 1-12
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-25111006, KAKENHI-PROJECT-25221101
[Journal Article] Krimper Enforces an Antisense Bias on piRNA Pools by Binding AGO3 in the Drosophila Germline.2015
- Author(s)
  Sato K, Iwasaki YW (equal contribution), Shibuya A, Carninci P, Tsuchizawa Y, Ishizu H, Siomi MC, Siomi H
- Journal Title
  
  Moleular Cell
  
  Volume: 59 Pages: 553-563
- DOI
  10.1016/j.molcel.2015.06.024
- Peer Reviewed / Open Access / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01473, KAKENHI-PROJECT-25221003, KAKENHI-PROJECT-25221101, KAKENHI-PROJECT-15H05583, KAKENHI-PROJECT-15H05585, KAKENHI-PROJECT-26870112
[Journal Article] Somatic Primary piRNA Biogenesis Driven by cis-Acting RNA Elements and trans-Acting Yb.2015
- Author(s)
  Ishizu H, Iwasaki YW, Hirakata S, Ozaki H, Iwasaki W, Siomi H, Siomi MC
- Journal Title
  
  Cell Reports.
  
  Volume: 12 Pages: 429-40
- DOI
  10.1016/j.celrep.2015.06.035
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PUBLICLY-15H01473, KAKENHI-PROJECT-221S0002, KAKENHI-PLANNED-26113004, KAKENHI-PROJECT-25221003, KAKENHI-PROJECT-25221101, KAKENHI-PROJECT-15H05583, KAKENHI-PROJECT-15H05585, KAKENHI-ORGANIZER-26113001
[Journal Article] Yb integrates piRNA intermediates and processing factors into perinuclear bodies to enhance piRISC assembly2014
- Author(s)
  Murota Y, Ishizu H, Nakagawa S, Iwasaki YW, Shibata S, Kamatani MK, Saito K, Okano H, Siomi H, Siomi MC.
- Journal Title
  
  Cell Rep
  
  Volume: 8 Pages: 103-113
- DOI
  10.1016/j.celrep.2014.05.043
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24500447, KAKENHI-ORGANIZER-25112001, KAKENHI-PLANNED-25112005, KAKENHI-PUBLICLY-25125704, KAKENHI-PROJECT-25221003, KAKENHI-PROJECT-25221101, KAKENHI-PROJECT-25830134, KAKENHI-PROJECT-25840004, KAKENHI-PLANNED-26113004, KAKENHI-PLANNED-26113005, KAKENHI-PROJECT-26711006, KAKENHI-PLANNED-26117007
[Presentation] Role of the RNA helicase, Armitage, in the primary piRNA biogenesis pathway2017
- Author(s)
  Ishizu, H., Kinoshita, T., Siomi, MC
- Organizer
  The 43rd Naito Conference on “NoncodingRNA: Biology, Chemistry, & Diseases”
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03632
[Presentation] Role of the RNA helicase, Armitage, in the primary piRNA biogenesis pathway2017
- Author(s)
  Ishizu, H., Kinoshita, T., Siomi, MC
- Organizer
  The 43rd Naito Conference on “NoncodingRNA: Biology, Chemistry, & Diseases”
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-16H01214
[Presentation] piRNA生合成経路によるmRNA分解制御2017
- Author(s)
  石津大嗣、塩見美喜子
- Organizer
  第19回日本RNA学会年会
- Data Source
  KAKENHI-PUBLICLY-16H01214
[Presentation] piRNA生合成経路によるmRNA分解制御2017
- Author(s)
  石津大嗣、塩見美喜子
- Organizer
  第19回日本RNA学会年会
- Data Source
  KAKENHI-PROJECT-16K14666
[Presentation] Role of the RNA helicase, Armitage, in the primary piRNA biogenesis pathway2017
- Author(s)
  Ishizu, H., Kinoshita, T., Siomi, MC
- Organizer
  The 43rd Naito Conference on “NoncodingRNA: Biology, Chemistry, & Diseases”
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K14666
[Presentation] piRNA生合成経路によるmRNA分解制御2017
- Author(s)
  石津大嗣、塩見美喜子
- Organizer
  第19回日本RNA学会年会
- Data Source
  KAKENHI-PROJECT-17H03632
[Presentation] piRNA生合成過程における中間体RNAの解析2016
- Author(s)
  荒川耕平,石津大嗣,塩見美喜子
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-25221101
[Presentation] Role of the RNA helicase, Armitage, in the primary piRNA biogenesis pathway2016
- Author(s)
  Ishizu, H., Kinoshita, T., Siomi, MC.
- Organizer
  The 2016 joint annual meeting of the RNA Society and the RNA Society of Japan,
- Place of Presentation
  国立京都国際会館（京都府京都市左京区）
- Year and Date
  2016-06-28
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K14666
[Presentation] Analysis of mitochondrial piRNA factors in Drosophila ovarian cells2016
- Author(s)
  Haruna Yamashiro, Horoki Kawamura, Hirotsugu Ishizu, and Mikiko C. Siomi
- Organizer
  RNA2016
- Place of Presentation
  国立京都国際会館（京都府京都市）
- Year and Date
  2016-05-28
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221101
[Presentation] Role of the RNA helicase, Armitage, in the primary piRNA biogenesis pathway2016
- Author(s)
  Ishizu, H., Kinoshita, T., Siomi, MC.
- Organizer
  The 2016 joint annual meeting of the RNA Society and the RNA Society of Japan
- Place of Presentation
  国立京都国際会館（京都府京都市左京区）
- Year and Date
  2016-06-28
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-16H01214
[Presentation] Role of the RNA helicase, Armitage, in the primary piRNA biogenesis pathway2016
- Author(s)
  Ishizu, H., Kinoshita, T., Siomi, MC.
- Organizer
  The 2016 joint annual meeting of the RNA Society and the RNA Society of Japan
- Place of Presentation
  国立京都国際会館（京都府京都市左京区）
- Year and Date
  2016-06-28
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05585
[Presentation] Genic piRNA biogenesis in Drosophila Ovarian Somatic Cells; its molecular mechanism and meaning2016
- Author(s)
  Kohei Arakawa, Hirotsugu Ishizu, Mikiko C Siomi
- Organizer
  CSHA conference on RNA Biology
- Place of Presentation
  蘇州市（中国）
- Year and Date
  2016-11-14
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221101
[Presentation] Elucidation of the primary piRNA pathway in Drosophila ovarian somatic cells2015
- Author(s)
  Hirotsugu Ishizu.
- Organizer
  EMBO/EMBL Symposia
- Place of Presentation
  Heidelberg（Germany）
- Year and Date
  2015-10-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221101
[Presentation] 人工piRNA発現システムを用いたpiRNA生合成機構の解析2015
- Author(s)
  石津大嗣
- Organizer
  第17回日本RNA学会年会
- Place of Presentation
  ホテルライフォート札幌（北海道・札幌市）
- Year and Date
  2015-07-16
- Data Source
  KAKENHI-PROJECT-25221101
[Presentation] Elucidation of the primary piRNA pathway in Drosophila ovarian somatic cells2015
- Author(s)
  Ishizu, H., Siomi, H., Siomi, MC.
- Organizer
  EMBO | EMBL Symposium: The Non-coding Genome
- Place of Presentation
  EMBL Advanced Training Centre (Germany・Heidelberg)
- Year and Date
  2015-10-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05585
[Presentation] piRNA生合成における前駆体RNA認識機構の解析2015
- Author(s)
  石津大嗣
- Organizer
  NGS現場の会第四回研究会
- Place of Presentation
  つくば国際会議場（茨城県・つくば市）
- Year and Date
  2015-07-01
- Invited
- Data Source
  KAKENHI-PROJECT-15H05585
[Presentation] 人工piRNA発現システムを用いたpiRNA生合成機構の解析2014
- Author(s)
  石津　大嗣、岩崎　由香、平形　樹生、福永　津嵩、尾崎　遼、木立　尚孝、岩崎　渉、塩見　春彦、塩見　美喜子
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2014-11-26
- Data Source
  KAKENHI-PUBLICLY-25125704
[Presentation] 人工piRNA発現システムを用いたpiRNA生合成機構の解析2014
- Author(s)
  石津　大嗣、平形　樹生、福永　津嵩、尾崎　遼、木立　尚孝、岩崎　渉、塩見　春彦、塩見　美喜子
- Organizer
  第16回日本RNA学会年会
- Place of Presentation
  ウインクあいち（愛知県名古屋市）
- Year and Date
  2014-07-23
- Data Source
  KAKENHI-PROJECT-25840004
[Presentation] 人工piRNA発現システムを用いたpiRNA生合成機構の解析2014
- Author(s)
  石津　大嗣、平形　樹生、福永　津嵩、尾崎　遼、木立　尚孝、岩崎　渉、塩見　春彦、塩見　美喜子
- Organizer
  第16回日本RNA学会年会
- Place of Presentation
  ウインクあいち（愛知県名古屋市）
- Year and Date
  2014-07-23
- Data Source
  KAKENHI-PUBLICLY-25125704
[Presentation] 人工piRNA発現システムを用いたpiRNA生合成機構の解析2014
- Author(s)
  石津　大嗣、岩崎　由香、平形　樹生、福永　津嵩、尾崎　遼、木立　尚孝、岩崎　渉、塩見　春彦、塩見　美喜子
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2014-11-26
- Data Source
  KAKENHI-PROJECT-25840004
[Presentation] 人工piRNA発現システムを用いたRNAサイレンシング機構の解析2013
- Author(s)
  石津大嗣
- Organizer
  第１５回日本RNA学会年会
- Place of Presentation
  ひめぎんホール (愛媛県)
- Invited
- Data Source
  KAKENHI-PROJECT-25840004
[Presentation] 人工piRNA発現システムを用いたRNAサイレンシング機構の解析2013
- Author(s)
  石津大嗣
- Organizer
  第１５回日本RNA学会年会
- Place of Presentation
  ひめぎんホール（愛媛県）
- Invited
- Data Source
  KAKENHI-PUBLICLY-25125704
[Presentation] primary piRNA生合成に働くcis-elementの探索
- Author(s)
  平形樹生、石津大嗣、塩見美喜子
- Organizer
  第16回日本RNA学会年会
- Place of Presentation
  ウインクあいち（名古屋市）
- Year and Date
  2014-07-23 – 2014-07-25
- Data Source
  KAKENHI-PROJECT-25221101
[Presentation] YbによるpiRNA生合成因子／piRNA前駆体の制御機構
- Author(s)
  室田友紀子、石津大嗣、中川真一、岩崎由香、芝田晋介、鎌谷太陽、齋藤都暁、岡野栄之、塩見春彦、塩見美喜子
- Organizer
  第16回日本RNA学会年会
- Place of Presentation
  ウインクあいち（名古屋市）
- Year and Date
  2014-07-23 – 2014-07-25
- Data Source
  KAKENHI-PROJECT-25221101
[Presentation] Yb integrates piRNA intermediates and processing factors into perinuclear bodies to enhance piRISC assembly
- Author(s)
  Yukiko Murota, Hirotsugu Ishizu, Shinichi Nakagawa, Yuka W. Iwasaki, Shinsuke Shibata, Miharu K. Kamatani, Kuniaki Saito, Hideyuki Okano, Haruhiko Siomi and Mikiko C. Siomi
- Organizer
  JAJRNA Meeting 2014
- Place of Presentation
  University of Technology Sydney（オーストラリア）
- Year and Date
  2014-11-01 – 2014-11-06
- Data Source
  KAKENHI-PROJECT-25221101

1. Siomi Mikiko (20322745)

# of Collaborated Projects: 1 results

# of Collaborated Products: 12 results
2. 三好智博 (60534550)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. IWASAKI Yuka

# of Collaborated Projects: 0 results

# of Collaborated Products: 7 results
4. SATO Kaoru

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. MURANO Kensaku

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 塩見春彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
7. 津村義彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 舘田英典

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 齋藤都暁

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
10. 岩崎渉

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 小松雅明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 芝田晋介

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 岡野栄之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 中川真一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Ishizu Hirotsugu 石津 大嗣

ISHIZU Hirotsugu 石津 大嗣

Research Projects

Research Products

Co-Researchers

Association between acquisition of virulence factors and Argonaute protein in bacteriaOngoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of piRNA biogenesis pathwayPrincipal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

piRNA生合成経路による翻訳制御機構Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Proteomic mapping of Yb body in live OSCs via APEX taggingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of molecular mechanisms of the primary piRNA pathwayPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

piRNAによる染色体構造制御機構の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the piRNA pathway and development of novel gene knock-down methodPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of molecular mechanisms of how piRNAs maintain the germline genome integrity from invasive mobile elements

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Use of the CRISPR-Cas9 system for genome editing in cultured Drosophila ovarian somatic cells2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Production of Small Non-coding RNAs from the flamenco Locus Is Regulated by the gypsy Retrotransposon of Drosophila melanogaster.2016

Author(s)

Journal Title

Data Source

[Journal Article] Piwi modulates chromatin accessibility by regulating multiple factors including histone H1 to repress transposons.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Production of Small Noncoding RNAs from the flamenco Locus Is Regulated by the gypsy Retrotransposon of Drosophila melanogaster.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Piwi Modulates Chromatin Accessibility by Regulating Multiple Factors Including Histone H1 to Repress Transposons2016

Author(s)

Journal Title

Data Source

[Journal Article] Krimper Enforces an Antisense Bias on piRNA Pools by Binding AGO3 in the Drosophila Germline.2015

Author(s)

Journal Title

DOI

Ishizu Hirotsugu 石津大嗣

ISHIZU Hirotsugu 石津大嗣