nakayama hiroyuki 中山博之

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NAKAYAMA Hiroyuki 中山博之

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Researcher Number	40581062
Other IDs
Affiliation (Current)	2025: 大阪大学, 大学院医学系研究科, 招へい准教授
Affiliation (based on the past Project Information) *help	2022 – 2024: 大阪大学, 大学院医学系研究科, 招へい准教授 2021: 大阪大学, 医学系研究科, 招へい准教授 2020: 大阪大学, 薬学研究科, 准教授 2019: 大阪大学, キャンパスライフ健康支援センター, 招へい准教授 2016 – 2018: 大阪大学, 薬学研究科, 准教授 2011 – 2016: Osaka University, 薬学研究科(研究院), 准教授 2010 – 2012: 大阪大学, 薬学研究科, 准教授
Review Section/Research Field	Principal Investigator Basic Section 53020:Cardiology-related / Cardiovascular medicine / Circulatory organs internal medicine / General pharmacology / General physiology Except Principal Investigator General pharmacology / Basic Section 48030:Pharmacology-related / Pathological medical chemistry
Keywords	Principal Investigator 心不全 / 心肥大 / 細胞死 / カルシウム / マイトファジー / 虚血再灌流 / β受容体 / ダウンレギュレーション / β1アドレナリン受容体 / 循環器・高血圧 … More / 老化 / アドレナリン受容体 / 線維芽細胞 / 心臓老化 / 心筋リモデリング / LRG / 心筋梗塞後リモデリング / 炎症 / マクロファージ / 血管新生 / リモデリング / 心筋梗塞 / ミトコンドリア / 転写因子 / プロテインキナーゼA / カルシウムチャネル / シグナリング / マイクロドメイン / カルモデュリン依存性キナーゼ / チャネル / G蛋白質共役受容体 / イノシトール三リン酸受容体 / カルシウムイオン … More Except Principal Investigator 心筋組織修復 / 心筋炎 / 心筋細胞増殖 / サイトカイン / 心不全 / 炎症 / 心血管・血液 / 治療標的 / 再生治療 / 心筋再生 / 再生 / 心筋 / Moesin / 循環器・高血圧 / STAT3 / 細胞骨格 / 組織修復・再生 / 心臓 / 心筋小胞体タンパク質 / 糖鎖 / STIM-1 / ホスホランバン / GSK3β / NFAT / 大動脈縮窄術 / O-GlcNAc転移酵素 / O-GlcNAc修飾 Less

マイトファジー関連蛋白質の虚血心における役割の解明及び創薬への基礎的検討Principal Investigator
- Principal Investigator
  
  中山博之
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Osaka University
心筋細胞内β受容体リサイクリング機構の解明と心不全創薬への応用Principal Investigator
- Principal Investigator
  
  中山博之
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Osaka University
Molecular mechanisms of cell proliferation of adult mammalian cardiomyocytes
- Principal Investigator
  
  Fujio Yasushi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 48030:Pharmacology-related
- Research Institution
  Osaka University
The role of beta adrenergic signaling in fibroblasts during cardiac senescencePrincipal Investigator
- Principal Investigator
  
  NAKAYAMA Hiroyuki
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Osaka University
The role of leucine-rich alpha2 glycoprotein in cardiac remodelingPrincipal Investigator
- Principal Investigator
  
  Nakayama Hiroyuki
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  General pharmacology
- Research Institution
  Osaka University
The molecular and cellular mechanism of myocardial repair/regeneration
- Principal Investigator
  
  FUJIO Yasushi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General pharmacology
- Research Institution
  Osaka University
Role of glycosylation on the functions of cardiac calcium regulating proteins and ion channels
- Principal Investigator
  
  Asahi Michio
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Osaka Medical College
The functional role of mitochondria innermembrane fusion inhibitor in heartPrincipal Investigator
- Principal Investigator
  
  NAKAYAMA Hiroyuki
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Osaka University
Myocardial inflammation of heart failure as a novel therapeutic target
- Principal Investigator
  
  FUJIO Yasushi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General pharmacology
- Research Institution
  Osaka University
Regulation of L-type calcium channel by intracellular subunit in cardiac hypertrophy and failure.Principal Investigator
- Principal Investigator
  
  NAKAYAMA HIROYUKI
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University
The transcriptional regulation of calcium induced cell death in heartPrincipal Investigator
- Principal Investigator
  
  NAKAYAMA Hiroyuki
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  General physiology
- Research Institution
  Osaka University
心不全におけるイノシトール三リン酸受容体の病態的意義の解明Principal Investigator
- Principal Investigator
  
  中山博之
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University

All 2022 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 Other

All Journal Article Presentation Book

[Book] 臨床薬理学2017
- Author(s)
  中山博之、藤尾慈
- Total Pages
  5
- Publisher
  医学書院
- Data Source
  KAKENHI-PROJECT-17K09576
[Book] 遺伝子医学MOOK別冊細胞死研究の今　–疾患との関わり、創薬に向けてのアプローチ−2013
- Author(s)
  中山博之、大津欣也
- Total Pages
  6
- Publisher
  メディカルドゥ
- Data Source
  KAKENHI-PROJECT-23390212
[Book] 遺伝子医学MOOK別冊細胞死研究の今
- Author(s)
  中山博之, 他
- Publisher
  メディカルドウ
- Data Source
  KAKENHI-PROJECT-23390212
[Journal Article] Rubicon-regulated beta-1 adrenergic receptor recycling protects the heart from pressure overload2022
- Author(s)
  Akazawa Yasuhiro、Taneike Manabu、Ueda Hiromichi、Kitazume-Taneike Rika、Murakawa Tomokazu、Sugihara Ryuta、Yorifuji Hiroki、Nishida Hiroki、Mine Kentaro、Hioki Ayana、Omiya Shigemiki、Nakayama Hiroyuki、Yamaguchi Osamu、Yoshimori Tamotsu、Sakata Yasushi、Otsu Kinya
- Journal Title
  
  Scientific Reports
  
  Volume: 12 Issue: 1 Pages: 41-41
- DOI
  10.1038/s41598-021-03920-6
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02913, KAKENHI-PROJECT-20K08448, KAKENHI-PROJECT-20K08491, KAKENHI-PROJECT-21K08104, KAKENHI-PROJECT-21K21350
[Journal Article] The CalcR-PKA-Yap1 Axis Is Critical for Maintaining Quiescence in Muscle Stem Cells.2019
- Author(s)
  Zhang L, Noguchi YT, Nakayama H, Kaji T, Tsujikawa K, Ikemoto-Uezumi M, Uezumi A, Okada Y, Doi T, Watanabe S, Braun T, Fujio Y, Fukada SI.
- Journal Title
  
  Cell Rep
  
  Volume: 19 Issue: 8 Pages: 2154-63
- DOI
  10.1016/j.celrep.2019.10.057
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19740, KAKENHI-PROJECT-19K22496, KAKENHI-PROJECT-18H02603, KAKENHI-PROJECT-19H04000, KAKENHI-PROJECT-18K19545
[Journal Article] Blockade of NKG2D/NKG2D ligand interaction attenuated cardiac remodeling after myocardial infarction2019
- Author(s)
  Matsumoto, K., Obana, M., Kobayashi, A., Miyagawa, S., Maeda, M., Sakata, Y., Nakayama, H., Sawa, Y., Fujio, Y.
- Journal Title
  
  Cardiovasc. Res.
  
  Volume: 115 Issue: 4 Pages: 765-775
- DOI
  10.1093/cvr/cvy254
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K19545, KAKENHI-PROJECT-18H02603
[Journal Article] Myofibroblast β2 adrenergic signaling amplifies cardiac hypertrophy in mice.2019
- Author(s)
  1.Imaeda A, Tanaka S, Tonegawa K, Fuchigami S, Obana M, Maeda M, Kihara M, Kiyonari H, Conway SJ, Fujio Y, Nakayama H.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 510 Issue: 1 Pages: 149-155
- DOI
  10.1016/j.bbrc.2019.01.070
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09576, KAKENHI-PROJECT-18K19545, KAKENHI-PROJECT-18H02603
[Journal Article] Mitochondrial DNA as an inflammatory mediator in cardiovascular diseases.2018
- Author(s)
  Nakayama H, Otsu K.
- Journal Title
  
  Biochem J.
  
  Volume: 475 Issue: 5 Pages: 839-852
- DOI
  10.1042/bcj20170714
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09576, KAKENHI-PROJECT-15H04822
[Journal Article] Caveolae-specific CaMKII signaling in the regulation of voltage-dependent calcium channel and cardiac hypertrophy.2018
- Author(s)
  Tanaka, S., Fujio, Y., Nakayama, H.
- Journal Title
  
  Front. Physiol.
  
  Volume: 9 Pages: 1081-1081
- DOI
  10.3389/fphys.2018.01081
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K19545, KAKENHI-PROJECT-18H02603
[Journal Article] Adult murine cardiomyocytes exhibit regenerative activity with cell cycle reentry through STAT3 in the healing process of myocarditis.2017
- Author(s)
  Miyawaki, A., Obana, M., Mitsuhara, Y., Orimoto, A., Nakayasu, Y., Yamashita, T., Fukada, S., Maeda, M., Nakayama, H., Fujio, Y.
- Journal Title
  
  Sci. Rep.
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26293054
[Journal Article] Caveolae-specific activation loop between CaMKII and L-type Ca2+ channel aggravates cardiac hypertrophy in α1-adrenergic stimulation.2017
- Author(s)
  Tonegawa K, Otsuka W, Kumagai S, Matsunami S, Hayamizu N, Tanaka S, Moriwaki K, Obana M, Maeda M, Asahi M, Kiyonari H, Fujio Y, Nakayama H.
- Journal Title
  
  Am J Physiol Heart Circ Physiol.
  
  Volume: 312
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460397
[Journal Article] Caveolae-specific activation loop between CaMKII and L-type Ca2+ channel aggravates cardiac hypertrophy in α1 adrenergic stimulation.2017
- Author(s)
  Tonegawa, K., Otsuka, W., Kumagai, S., Matsunami, S., Hayamizu, N., Tanaka, S., Moriwaki, K., Obana, M., Maeda, M., Asahi, M., Kiyonari, H., Fujio, Y., Nakayama, H.
- Journal Title
  
  Am. J. Physiol. Heart Circ. Physiol.
  
  Volume: ３１２ Issue: 3 Pages: H501-H514
- DOI
  10.1152/ajpheart.00601.2016
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26293054, KAKENHI-PROJECT-15K08232
[Journal Article] RORγt-expressing cells attenuate cardiac remodeling after myocardial infarction.2017
- Author(s)
  Enomoto D, Matsumoto K, Yamashita T, Kobayashi A, Maeda M, Nakayama H, Obana M, Fujio Y.
- Journal Title
  
  PLoS One.
  
  Volume: 12 Issue: 8 Pages: e0183584-e0183584
- DOI
  10.1371/journal.pone.0183584
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09576, KAKENHI-PROJECT-15K08232, KAKENHI-PROJECT-15K18987
[Journal Article] Phospholamban inhibition by a single dose administration of locked nucleic acid antisense oligonucleotide improves cardiac contractility in pressure overload-induced systolic dysfunction in mice.2017
- Author(s)
  Morihara, H., Yamamoto, T., Oiwa, H., Tonegawa, K., Tsuchiyama, D., Kawakatsu, I., Obana, M., Maeda, M., Mohri, T., Obika, S., Fujio, Y., Nakayama, H.
- Journal Title
  
  J. Cardiovasc. Pharmacol. Ther.
  
  Volume: 印刷中 Issue: 3 Pages: 273-282
- DOI
  10.1177/1074248416676392
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26293054, KAKENHI-PROJECT-15K15052, KAKENHI-PROJECT-15K08232, KAKENHI-PROJECT-17K09576
[Journal Article] Adult murine cardiomyocytes exhibit regenerative activity with cell cycle reentry through STAT3 in the healing process of myocarditis.2017
- Author(s)
  Miyawaki A, Obana M, Mitsuhara Y, Orimoto A, Nakayasu Y, Yamashita T, Fukada SI, Maeda M, Nakayama H, Fujio Y.
- Journal Title
  
  Sci Rep.
  
  Volume: 7 Issue: 1 Pages: 1407-1407
- DOI
  10.1038/s41598-017-01426-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09576, KAKENHI-PROJECT-15K08232, KAKENHI-PROJECT-15K18987
[Journal Article] 2-aminoethoxydiphenyl borate provides an anti-oxidative effect and mediates cardioprotection during ischemia reperfusion in mice.2017
- Author(s)
  Morihara H, Obana M, Tanaka S, Kawakatsu I, Tsuchiyama D, Mori S, Suizu H, Ishida A, Kimura R, Tsuchimochi I, Maeda M, Yoshimitsu T, Fujio Y, Nakayama H.
- Journal Title
  
  PLoS One.
  
  Volume: 12 Issue: 12 Pages: e0189948-e0189948
- DOI
  10.1371/journal.pone.0189948
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09576, KAKENHI-PROJECT-15K08232, KAKENHI-PROJECT-15K14977
[Journal Article] Moesin is activated in cardiomyocytes in experimental autoimmune myocarditis and mediates cytoskeletal reorganization with protrusion formation2016
- Author(s)
  Akimitsu Miyawaki, Yusuke Mitsuhara, Aya Orimoto, Yusuke Nakayasu, Shin-ichi Tsunoda, Masanori Obana, Makiko Maeda, Hiroyuki Nakayama, Yasuo Yoshioka, Yasuo Tsutsumi, Yasushi Fujio
- Journal Title
  
  The American Journal of Physiology-Heart and Circulatory Physiology
  
  Volume: 311 Issue: 2 Pages: 476-486
- DOI
  10.1152/ajpheart.00180.2016
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16J05326, KAKENHI-PROJECT-26293054, KAKENHI-PROJECT-15K15052, KAKENHI-PROJECT-15K08232, KAKENHI-PROJECT-15K18987
[Journal Article] Macromolecular Degradation Systems and Cardiovascular Aging.2016
- Author(s)
  Nakayama H, Nishida K, Otsu K.
- Journal Title
  
  Circ Res
  
  Volume: 118 Issue: 10 Pages: 1577-92
- DOI
  10.1161/circresaha.115.307495
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K15052
[Journal Article] Myeloid cell-derived LRG attenuates adverse cardiac remodeling after myocardial infarction.2016
- Author(s)
  Kumagai, S., Nakayama, H., Fujiomoto, M., Honda, H., Serada, S., Ishibashi-Ueda, H., Kasai, A., Obana, M., Sawa, Y., Fujio, Y., Naka, T.
- Journal Title
  
  Cardiovasc. Res.
  
  Volume: 109 Issue: 2 Pages: 272-282
- DOI
  10.1093/cvr/cvv273
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26293054, KAKENHI-PROJECT-15K15052
[Journal Article] Persistent increases in Ca(2+) influx through Cav1.2 shortens action potential and causes Ca(2+) overload-induced afterdepolarizations and arrhythmias.2016
- Author(s)
  Zhang X, Ai X, Nakayama H, Chen B, Harris DM, Tang M, Xie Y, Szeto C, Li Y, Li Y, Zhang H, Eckhart AD, Koch WJ, Molkentin JD, Chen X.
- Journal Title
  
  Basic Res Cardiol
  
  Volume: 111 Issue: 1 Pages: 4-4
- DOI
  10.1007/s00395-015-0523-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K15052
[Journal Article] Cardiac specific ablation of STAT3 gene in subacute phase of myocardial infarction exacerbated cardiac remodeling.2015
- Author(s)
  Enomoto, D., Obana, M., Miyawaki, A., Maeda, M., Nakayama, H., Fujio, Y.
- Journal Title
  
  Am. J. Physiol. Heart Circ. Physiol.
  
  Volume: 3０９ Issue: 3 Pages: H471-H480
- DOI
  10.1152/ajpheart.00730.2014
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08232, KAKENHI-PROJECT-15K15052, KAKENHI-PROJECT-26293054
[Journal Article] The Inhibition of N-Glycosylation of Glycoprotein 130 Molecule Abolishes STAT3 Activation by IL-6 Family Cytokines in Cultured Cardiac Myocytes.2014
- Author(s)
  Matsuo R, Morihara H, Mohri T, Murasawa S, Takewaki K, Nakayama H, Maeda M, Fujio Y.
- Journal Title
  
  PLoS One
  
  Volume: 23 Issue: 10 Pages: e111097-e111097
- DOI
  10.1371/journal.pone.0111097
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25670193, KAKENHI-PROJECT-25670387, KAKENHI-PROJECT-25860061, KAKENHI-PROJECT-26293054
[Journal Article] Toll-like receptor 9 protects non-immune cells from stress by modulating mitochondrial ATP synthesis through the inhibition of SERCA2.2014
- Author(s)
  Shintani Y, Drexler HC, Kioka H, Terracciano CM, Coppen SR, Imamura H, Akao M, Nakai J, Wheeler AP, Higo S, Nakayama H, Takashima S, Yashiro K, Suzuki K.
- Journal Title
  
  EMBO Reports
  
  Volume: 15 Issue: 4 Pages: 438-445
- DOI
  10.1002/embr.201337945
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23390212, KAKENHI-PROJECT-24657101, KAKENHI-PROJECT-24790757, KAKENHI-PUBLICLY-25111703, KAKENHI-PROJECT-25461346, KAKENHI-PROJECT-25670387, KAKENHI-PUBLICLY-26115504, KAKENHI-PROJECT-26291027, KAKENHI-PROJECT-26560456, KAKENHI-PROJECT-26860559
[Journal Article] Toll-like receptor 9 protects non-immune cells from stress by modulating mitochondrial ATP synthesis through the inhibition of SERCA22014
- Author(s)
  Shintani Y, Drexler HC, Kioka H, Terracciano CM, Coppen SR, Imamura H, Akao M, Nakai J, Wheeler AP, Higo S, Nakayama H, 他3名
- Journal Title
  
  EMBO Rep
  
  Volume: 15(4) Pages: 438-45
- Data Source
  KAKENHI-PROJECT-23390212
[Journal Article] Genetic modulation of the SERCA activity does not affect the Ca2+ leak from the cardiac sarcoplasmic reticulum.2014
- Author(s)
  Morimoto S, Hongo K, Kusakari Y, Komukai K, Kawai M, O-Uchi J, Nakayama H, Asahi M, Otsu K, Yoshimura M, Kurihara S.
- Journal Title
  
  Cell Calcium.
  
  Volume: 55 Issue: 1 Pages: 17-23
- DOI
  10.1016/j.ceca.2013.10.005
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23390212, KAKENHI-PROJECT-23790255, KAKENHI-PUBLICLY-25136719, KAKENHI-PROJECT-25460397, KAKENHI-PROJECT-25670387
[Journal Article] Genetic modulation of the SERCA activity does not affect the Ca2+ leak from the cardiac sarcoplasmic reticulum2014
- Author(s)
  Morimoto S, Hongo K, Kusakari Y, Komukai K, Kawai M, O-Uchi J, Nakayama H, 他4名
- Journal Title
  
  Cell Calcium
  
  Volume: 55(1) Pages: 17-23
- Data Source
  KAKENHI-PROJECT-23390212
[Journal Article] Autophagy-mediated degradation is necessary for regression of cardiac hypertrophy during ventricular unloading.2013
- Author(s)
  Oyabu J, Yamaguchi O, Hikoso S, Takeda T, Oka T, Murakawa T, Yasui H, Ueda H, Nakayama H, Taneike M, Omiya S, Shah AM, Nishida K, Otsu K.
- Journal Title
  
  Biochemical and Biophysical Research Communication
  
  Volume: 441 Issue: 4 Pages: 787-792
- DOI
  10.1016/j.bbrc.2013.10.135
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390212, KAKENHI-PROJECT-23689042, KAKENHI-PROJECT-25713031
[Journal Article] Genetic polymorphisms of CYP17A1 in steroidogenesis pathway are associated with risk of progression to castration-resistant prostate cancer in Japanese men receiving androgen deprivation therapy2013
- Author(s)
  Yamada, T. Nakayama, M., Shimizu, T., Nonen, S., Nakai, Y., Nishimura, K., Fujio, Y., Okuyama, A., Azuma, J., Nonomura, N
- Journal Title
  
  Int. J. Clin. Oncol
  
  Volume: 18 Pages: 711-717
- Data Source
  KAKENHI-PROJECT-23390057
[Journal Article] Ca2+依存性の心肥大・心筋細胞死誘導シグナル2013
- Author(s)
  中山博之、山口修、藤尾慈
- Journal Title
  
  Clinical Calcium
  
  Volume: 23 Pages: 505-515
- Data Source
  KAKENHI-PROJECT-23390212
[Journal Article] Cathelicidin antimicrobial peptide inhibits fibroblast migration via P2X7 receptor signaling2013
- Author(s)
  Kumagai, S., Matsui, K., Kawaguchi, H., Yamashita, T., Mohri, T., Fujio, Y., Nakayama, H
- Journal Title
  
  Biochem. Biophys. Res. Commun
  
  Volume: 437 Pages: 609-614
- Data Source
  KAKENHI-PROJECT-23390057
[Journal Article] Calcium dependent signaling in cardiac hypertrophy and cell death2013
- Author(s)
  Nakayama H, Fujio Y, Yamaguchi O
- Journal Title
  
  Clin Calcium
  
  Volume: 23(4) Pages: 505-15
- Data Source
  KAKENHI-PROJECT-23390212
[Journal Article] Cathelicidin antimicrobial peptide inhibits fibroblast migration via P2X7 receptor signaling.2013
- Author(s)
  Kumagai, S., Matsui, K., Kawaguchi, H., Yamashita, T., Mohri, T., Fujio, Y., Nakayama, H.
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 437 Issue: 4 Pages: 609-614
- DOI
  10.1016/j.bbrc.2013.07.010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390057, KAKENHI-PROJECT-23390212, KAKENHI-PROJECT-25670193, KAKENHI-PROJECT-25860061
[Journal Article] Ras Homologue Enriched in Brain (Rheb) -dependent mTORC1 Activation Becomes Indispensable for Cardiac Hypertrophic Growth after Early Postnatal Period2013
- Author(s)
  Tamai T, Yamaguchi O, Hikoso S, Takeda T, Taneike M, Oka T, Oyabu J, Murakawa T, Nakayama H, 他6名
- Journal Title
  
  J Biol Chem
  
  Volume: 288(5) Pages: 10176-87
- Data Source
  KAKENHI-PROJECT-23390212
[Journal Article] Genetic polymorphisms of CYP17A1 in steroidogenesis pathway are associated with risk of progression to castration-resistant prostate cancer in Japanese men receiving androgen deprivation therapy2012
- Author(s)
  Takeshi Yamada, Masashi Nakayama, Tomohito Shimizu, Shinpei Nonen, et al.
- Journal Title
  
  Int J Clin Oncol
  
  Volume: (in press) Issue: 4 Pages: 711-718
- DOI
  10.1007/s10147-012-0430-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790515, KAKENHI-PROJECT-23390057, KAKENHI-PROJECT-23390143, KAKENHI-PROJECT-25670193
[Journal Article] Therapeutic administration of IL-11 exhibits the postconditioning effects against ischemia-reperfusion injury via STAT3 in the heart2012
- Author(s)
  Obana, M. Miyamoto, K., Murasawa, S., Iwakura, T., Hayama, A., Yamashita, T., Shiragaki, M., Kumagai, S., Miyawaki, A., Takewaki, K., Matsumiya, G., Maeda, M., Yoshiyama, M., Nakayama, H., Fujio, Y
- Journal Title
  
  Am. J. Physiol. Heart Circ. Physiol
  
  Volume: 303
- Data Source
  KAKENHI-PROJECT-23390057
[Journal Article] Ca2+-mediated pathogenesis in the heart2012
- Author(s)
  Nakayama H
- Journal Title
  
  Nihon Yakurigaku Zasshi
  
  Volume: 140 Pages: 270-274
- NAID
  10031130802
- Data Source
  KAKENHI-PROJECT-23390057
[Journal Article] JAK/STAT signaling in cardiomyogenesis of cardiac stem cells2012
- Author(s)
  Mohri, T., Iwakura, T., Nakayama, H. Fujio, Y
- Journal Title
  
  JAK/STAT
  
  Volume: 1 Pages: 125-130
- Data Source
  KAKENHI-PROJECT-23390057
[Journal Article] Association between osteopontin promoter variants and diastolic dysfunction in hypertensive heart in the Japanese population2011
- Author(s)
  Nakayama, H., Nagai, H., Matsumoto, K., Oguro, R., Sugimoto, K., Kamide, K., Ohishi, M., Katsuya, T., Okamoto, H., Maeda, M., Komamura, K., Azuma, J., Rakugi, H., Fujio, Y
- Journal Title
  
  Hypertension Res
  
  Volume: 34 Pages: 1141-1146
- NAID
  10030276721
- Data Source
  KAKENHI-PROJECT-23390057
[Journal Article] IL-6-mediated Th17 differentiation through RORγt is essential for the initiation of experimental autoimmune myocarditis2011
- Author(s)
  Yamashita, T., Iwakura, T., Matsui, K., Kawaguchi, H., Obana, M., Hayama, A., Maeda, M, Izumi, Y., Komuro, I., Ohsugi, Y., Fujimoto, M., Naka, T., Kishimoto, T., Nakayama, H., Fujio, Y
- Journal Title
  
  Cardiovasc. Res
  
  Volume: 91 Pages: 640-648
- Data Source
  KAKENHI-PROJECT-23390057
[Journal Article] STAT3/Pim-1 signaling pathway plays a crucial role in endothelial differentiation of cardiac resident Sca-1+ cells both in vitro and in vivo2011
- Author(s)
  Iwakura, T., Mohri, T., Hamatani, T., Obana, M., Yamashita, T., Maeda, M., Katakami, N., Kaneto, H., Komuro, I., Azuma, J., Nakayama, H., Fujio, Y
- Journal Title
  
  J. Mol. Cell. Cardiol
  
  Volume: 51 Pages: 207-214
- Data Source
  KAKENHI-PROJECT-23390057
[Journal Article] Glycoprotein130 cytokine signal as a therapeutic target against cardiovascular diseases2011
- Author(s)
  Fujio, Y., Maeda, M., Mohri, M., Obana, M., Iwakura, T., Hayama, A., Yamashita, T., Nakayama, H., Azuma, J
- Journal Title
  
  J. Pharmacol. Sci
  
  Volume: 117 Pages: 213-222
- NAID
  10030453480
- Data Source
  KAKENHI-PROJECT-23390057
[Journal Article] The IP3 receptor Regulates Cardiac Hypertrophy in Response to Select Stimuli2010
- Author(s)
  中山博之
- Journal Title
  
  Circulation Research
  
  Volume: 107 Pages: 659-666
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22890105
[Journal Article] Autophagy-mediated degradation is necessary for regression of cardi ac hypertrophy during ventricular unloading
- Author(s)
  Oyabu J, Yamaguchi O, Hikoso S, Takeda T, Oka T, Murakawa T, Yasui H, Ueda H, Nakayama H, 他5名
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 441(4) Pages: 787-92
- Data Source
  KAKENHI-PROJECT-23390212
[Journal Article] Cathelicidin antimicrobial peptide inhibits fibroblast migration via P2X7 receptor signaling
- Author(s)
  Kumagai S, Matsui K, Kawaguchi H, Yamashita T, Mohri T, Fujio Y, Nakayama H
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 437(4) Pages: 609-14
- Data Source
  KAKENHI-PROJECT-23390212
[Presentation] Runx2発現ミエロイド細胞は梗塞後心筋リモデリングを抑制する新規心保護サブセットである2019
- Author(s)
  松本浩太朗、芦塚萌、熊谷渉平、奥崎大介、尾花理徳、前田真貴子、中山博之、藤尾　慈
- Organizer
  日本薬理学会92回年会
- Data Source
  KAKENHI-PROJECT-18H02603
[Presentation] 成体マウスにおける単核心筋細胞の特性解析2019
- Author(s)
  中安佑介、松井理紗、福山尚希、亀谷祐介、和田祐理子、尾花理徳、前田真貴子、中山博之、藤尾慈
- Organizer
  日本薬理学会92回年会
- Data Source
  KAKENHI-PROJECT-18H02603
[Presentation] ポドサイトにおけるOASISの発現抑制は糖尿病による腎機能の悪化を抑制する2019
- Author(s)
  4.三宅芳明、尾花威徳、山本彩葉、野田竣介、金本聡自、前田真貴子、淺沼克彦、今泉和則、中山博之、藤尾慈
- Organizer
  日本薬理学会92回年会
- Data Source
  KAKENHI-PROJECT-18H02603
[Presentation] CGRRF1の過剰発現は培養心筋細胞の肥大を誘導する2019
- Author(s)
  木下真希、尾花理徳、前田真貴子、中山博之、藤尾慈
- Organizer
  日本薬理学会92回年会
- Data Source
  KAKENHI-PROJECT-18H02603
[Presentation] Blockade of NKG2D / NKG2D Ligand Interaction Attenuated Post-Infarct Myocardial Injury.2018
- Author(s)
  Matsumoto, K., Obana, M., Kobayashi, A.,Kihara, M.,Shioi, G., Miyagawa, S., Maeda, M.,Sakata,Y., Nakayama, H., Sawa, Y.,Fujio, Y.
- Organizer
  American Heart Association Scientific Sessions 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02603
[Presentation] Blockade of NKG2D / NKG2D ligands interaction as a novel therapeutic strategy against heart failure2018
- Author(s)
  Matsumoto. K., Obana. M., Maeda. M., Nakayama. H.,Fujio. Y.
- Organizer
  18th World Congress of Basic And Clinical Pharmacology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02603
[Presentation] 骨髄細胞特異的Runx2の欠損は心筋梗塞後の心筋リモデリングを悪化させる2017
- Author(s)
  芦塚萌　熊谷渉平　柳瀬絵美子　松本浩太朗　尾花理徳　前田真貴子　中山博之　藤尾慈
- Organizer
  第90回日本薬理学会年会
- Place of Presentation
  長崎県長崎市
- Year and Date
  2017-03-15
- Data Source
  KAKENHI-PROJECT-26293054
[Presentation] Moesinは実験的自己免疫性心筋炎モデルにおいて活性化し、仮足形成を伴う組織修復に関与する2017
- Author(s)
  密原佑介　宮脇昭光　折本彩　中安祐介　角田慎一　尾花理徳　前田真貴子　中山博之　吉岡靖雄　堤康央　藤尾慈
- Organizer
  第90回日本薬理学会年会
- Place of Presentation
  長崎県長崎市
- Year and Date
  2017-03-15
- Data Source
  KAKENHI-PROJECT-26293054
[Presentation] eIF4Bは、Pim-1キナーゼの下流における心筋細胞保護因子である2017
- Author(s)
  横山由加里　松本浩太朗　木下真希　尾花理徳　前田真貴子　中山博之　藤尾慈
- Organizer
  第90回日本薬理学会年会
- Place of Presentation
  長崎県長崎市
- Year and Date
  2017-03-15
- Data Source
  KAKENHI-PROJECT-26293054
[Presentation] Myofibroblast-specific deletion of Runx2 improves systolic function and survival in late phase of cardiac remodeling after myocardial infarction.2017
- Author(s)
  Shota Tanaka, Daichi Enomoto, Emiko Yanase, Shohei Kumagai, Masanori Obana, Makiko Maeda, Yasushi Fujio, Hiroyuki Nakayama
- Organizer
  American Heart Association Scientific Sessions 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09576
[Presentation] 心筋炎回復過程における心筋細胞の内因性増殖機構の解析2017
- Author(s)
  折本彩、中安佑介、松井理沙、宮脇昭光、尾花理徳、前田真貴子、中山博之、藤尾慈
- Organizer
  日本薬理学会近畿部会
- Data Source
  KAKENHI-PROJECT-17K09576
[Presentation] 心筋細胞におけるR-spondin1の形態学的機能2017
- Author(s)
  関谷有紀子、尾花理徳、宮脇昭光、松本浩太郎、榎本大智、前田真貴子、中山博之、藤尾慈
- Organizer
  日本薬理学会近畿部会
- Data Source
  KAKENHI-PROJECT-17K09576
[Presentation] 腎線維化病態における転写因子OASISの役割2017
- Author(s)
  守沖瞳、尾花理徳、山本彩葉、金本聡自、前田真貴子、今泉和則、中山博之、藤尾慈
- Organizer
  日本薬理学会近畿部会
- Data Source
  KAKENHI-PROJECT-17K09576
[Presentation] 細胞死抑制因子Dad1の心筋細胞における意義2017
- Author(s)
  木村瑠美、松本浩太郎、森原啓文、尾花理徳、前田真貴子、藤尾慈、中山博之
- Organizer
  日本薬理学会近畿部会
- Data Source
  KAKENHI-PROJECT-17K09576
[Presentation] RORgammatのヘテロ欠損は心筋梗塞後の心筋リモデリングを悪化させる2017
- Author(s)
  榎本大智　尾花理徳　松本浩太朗　前田真貴子　中山博之　藤尾慈
- Organizer
  第90回日本薬理学会年会
- Place of Presentation
  長崎県長崎市
- Year and Date
  2017-03-15
- Data Source
  KAKENHI-PROJECT-26293054
[Presentation] Fibroblast-specific beta2 adrenergic receptor signaling regulates cardiac hypertrophy in mice.2016
- Author(s)
  Kota Tonegawa, Shota Tanaka, Misato Takahashi, Shota Fuchigami, Masanori Obana, Makiko Maeda, Yasushi Sakata, Yasushi Fujio, Hiroyuki Nakayama
- Organizer
  American Heart Association 2016 Scientific Sessions
- Place of Presentation
  New Orleans
- Year and Date
  2016-11-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15052
[Presentation] Adult mammalian hearts restore intrinsic regenerative capacity through signal transducer and activator of transcription 3 in the resolution phase of myocarditis.2016
- Author(s)
  Miyawaki, A., Obana, M., Mitsuhara, Y., Orimoto, A., Nakayasu, Y., Yamashita, T., Fukada, S., Maeda, M., Sakata, Y., Nakayama, H., Fujio, Y.
- Organizer
  American Heart Association Scientific Sessions
- Place of Presentation
  New Orleans. USA.
- Year and Date
  2016-11-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293054
[Presentation] Heterozygous ablation of RORγt gene deteriorates adverse cardiac remodeling after myocardial infarction.2016
- Author(s)
  Enomoto, D., Obana, M., Matsumoto, K., Sakata, Y., Maeda, M., Nakayama, H., Fujio, Y.
- Organizer
  American Heart Association Scientific Sessions
- Place of Presentation
  New Orleans. USA.
- Year and Date
  2016-11-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293054
[Presentation] Heterozygous ablation of RORγt gene deteriorates adverse cardiac remodeling after myocardial infarction2016
- Author(s)
  Daichi Enomoto, Masanori Obana, Kotaro Matsumoto, Yasushi Sakata, Makiko Maeda, Hiroyuki Nakayama, Yasushi Fujio
- Organizer
  American Heart Association 2016 Scientific Sessions
- Place of Presentation
  New Orleans
- Year and Date
  2016-11-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15052
[Presentation] Myeloid cell-specific Runx2 deficiency exacerbates adverse cardiac remodeling after myocardial infarction2016
- Author(s)
  Moe Ashizuka,　Shohei Kumagai, Emiko Yanase, Masanori Obana,　Makiko Maeda, Yasushi Sakata, Hiroyuki Nakayama, Yasushi Fujio
- Organizer
  American Heart Association 2016 Scientific Sessions
- Place of Presentation
  New Orleans
- Year and Date
  2016-11-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15052
[Presentation] Myeloid cell-specific Runx2 deficiency exacerbates adverse cardiac remodeling after myocardial infarction.2016
- Author(s)
  Ashizuka, M.,　Kumagai, S., Yanase, E., Obana, M.,　Maeda, M., Sakata, Y., Nakayama, H., Fujio, Y.
- Organizer
  American Heart Association Scientific Sessions
- Place of Presentation
  New Orleans. USA.
- Year and Date
  2016-11-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293054
[Presentation] 心筋炎病態下におけるSTAT3を介した成体心筋細胞増殖2016
- Author(s)
  宮脇昭光　高家圭紀　密原佑介　山下朋美　尾花理徳　前田真貴子　中山博之　藤尾慈
- Organizer
  第89回日本薬理学会年会
- Place of Presentation
  横浜　パシフィコ横浜
- Year and Date
  2016-03-09
- Data Source
  KAKENHI-PROJECT-26293054
[Presentation] Adult Mammalian Hearts Restore Intrinsic Regenerative Capacity through Signal Transducer and Activator of Transcription 3 in the Resolution Phase of Myocarditis2016
- Author(s)
  Akimitsu Miyawaki, Masanori Obana, Yusuke Mitsuhara, Aya Orimoto, Yusuke Nakayasu, Tomomi Yamashita, So-ichiro Fukada, Makiko Maeda, Yasushi Sakata, Hiroyuki Nakayama, Yasushi Fujio.
- Organizer
  American Heart Association 2016 Scientific Sessions
- Place of Presentation
  New Orleans
- Year and Date
  2016-11-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15052
[Presentation] Fibroblast-specific beta2 adrenergic receptor signaling regulates cardiac hypertrophy in mice.2016
- Author(s)
  Tonegawa, K., Tanaka, S., Takahashi, M., Fuchigami, S., Obana, M., Maeda, M., Sakata, Y., Fujio, Y,. Nakayama, H.
- Organizer
  American Heart Association Scientific Sessions
- Place of Presentation
  New Orleans. USA.
- Year and Date
  2016-11-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293054
[Presentation] Myeloid Cell Derived Leucine Rich α2 Glycoprotein Attenuates Adverse Cardiac Remodeling After Myocardial Infarction.2015
- Author(s)
  4.Kumagai S, Nakayama H, Fujimoto M, Honda H, Serada S, Kasai A, Obana M, Sakata Y, Sawa Y, Naka T, Fujio Y
- Organizer
  American Heart Association Scientific Session 2015
- Place of Presentation
  米国オーランド
- Year and Date
  2015-11-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15052
[Presentation] Blockade of NKG2D/NKG2D Ligands Interaction Attenuated Cardiac Remodeling after Myocardial Infarction2015
- Author(s)
  Kotaro Matsumoto, Masanori Obana, Rina Hashidzume, Yukari Yokoyama,Nakayama, Shigeru Miyagawa, Tomomi Mohri, Makiko Maeda, Yasushi Sakata, Hiroyuki Nakayama, Yoshiki Sawa, Yasushi Fujio
- Organizer
  American Heart Association Scientific Sessions 2015
- Place of Presentation
  Orlando
- Year and Date
  2015-11-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293054
[Presentation] Blockade of NKG2D / NKG2D Ligands Interaction Attenuated Cardiac Remodeling After Myocardial Infarction.2015
- Author(s)
  2.Matsumoto K, Obana M, Hashizume R, Yokoyama Y, Miyagawa S, Mohri T, Maeda M, Nakayama H, Sawa Y, Fujio Y.
- Organizer
  American Heart Association Scientific Session 2015
- Place of Presentation
  米国オーランド
- Year and Date
  2015-11-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15052
[Presentation] Myeloid Cell Derived Leucine Rich α2 Glycoprotein Attenuates AdverseCardiac Remodeling After Myocardial Infarction.2015
- Author(s)
  Shohei Kumagai, Hiroyuki Nakayama, Minoru Fujimoto, Hiromi Honda, Satoshi Serada, Atsushi Kasai, Masanori Obana, Yasushi Sakata, Yoshiki Sawa, Tetsuji Naka, Yasushi Fujio
- Organizer
  American Heart Association Scientific Sessions 2015
- Place of Presentation
  Ｏｒｌａｎｄｏ
- Year and Date
  2015-11-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293054
[Presentation] Adrenergic Receptors β2 and β3 Transduce Differential Signals in Cardiac Fibroblasts.2015
- Author(s)
  3.Tonegawa K, Nakayama H, Igarashi H, Matsunami S, Hayamizu N, Obana M, Maeda M, Fujio Y.
- Organizer
  American Heart Association Scientific Session 2015
- Place of Presentation
  米国オーランド
- Year and Date
  2015-11-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15052
[Presentation] Cardiac STAT3 Activation in Subacute Phase of Myocardial Infarction was Required for the Suppression of Adverse Cardiac Remodeling.2015
- Author(s)
  1.Enomoto D, Obana M, Miyawaki A, Mohri T, Maeda M, Sakata Y, Nakayama H, Fujio Y.
- Organizer
  American Heart Association Scientific Session 2015
- Place of Presentation
  米国オーランド
- Year and Date
  2015-11-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15052
[Presentation] Cardiac STAT3 activation in subacute phase of myocardial infarction was required for the suppression of adverse cardiac remodeling2015
- Author(s)
  Daichi Eonomoto, Masanori Obana, Akimitsu Miyawaki, Makiko Maeda, Hiroyuki Nakayama, Yasushi Fujio
- Organizer
  American Heart Association Scientific Sessions 2015
- Place of Presentation
  Orlando
- Year and Date
  2015-11-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293054
[Presentation] マクロファージ特異的なCD93過剰発現による死細胞貪食の増強は心筋梗塞後の心筋線維化を抑制する2014
- Author(s)
  竹脇佳那，山下朋美，宮本香織，毛利友美，中山博之，藤尾慈
- Organizer
  第87回日本薬理学会年会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-23390057
[Presentation] BIN1の過剰発現は心筋細胞死を介して心筋リモデリングを増悪する2014
- Author(s)
  舎川洸太，松浪佐知，土山大介，中山博之，藤尾慈
- Organizer
  第87回日本薬理学会年会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-23390057
[Presentation] Excessive BIN1 expression results in adeverse remodeling through cardiomyocyte death2014
- Author(s)
  Kota Tonegawa, Sachi Matsunami, Daisuke Tsuchiyama, Hiroyuki Nakayama, Yasushi Fujio
- Organizer
  日本薬理学会
- Place of Presentation
  仙台国際センター（仙台）
- Data Source
  KAKENHI-PROJECT-23390212
[Presentation] L 型カルシウムチャネルβ2a サブユニットのリン酸化は心筋細胞肥大を惹起する2014
- Author(s)
  早水菜穂, 熊谷渉平, 松浪佐知, 中山博之, 藤尾慈
- Organizer
  第87回日本薬理学会年会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-23390057
[Presentation] L型カルシウムチャネルβ2aサブユニットのリン酸化は心筋細胞肥大を惹起する2014
- Author(s)
  早水菜穂，熊谷渉平，松浪佐知，中山博之，藤尾慈
- Organizer
  第87回日本薬理学会年会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-23390057
[Presentation] ミトコンドリア融合阻害因子MIFIによる心病態の増悪機序に関する解析－遺伝子発現プロフィール解析－2014
- Author(s)
  田中翔大, 新谷紀人, 中山博之, 東信太朗, 開菜摘, 舎川洸太, 藤尾慈, 井上直紀, 笠井淳司, 早田敦子, 橋本均, 馬場明道
- Organizer
  第125回日本薬理学会近畿部会
- Place of Presentation
  岡山コンベンションセンター（岡山県岡山市）
- Year and Date
  2014-06-20
- Data Source
  KAKENHI-PROJECT-25670387
[Presentation] Caveolae-specific phosphorylation of L-type calcium channel 2a subunit exaggerates cardiac hypertrophic responses after 1 adrenergic stimulation in mice.2014
- Author(s)
  Hiroyuki Nakayama, Shohei Kumagai, Sachi Matsunami, Nao Hayamizu Wataru Otsuka and Yasushi Fujio.
- Organizer
  Basic Cardiovascular Sciences/American Heart Association
- Place of Presentation
  Paris Las Vegas (ラスベガス）
- Data Source
  KAKENHI-PROJECT-23390212
[Presentation] BIN1 の過剰発現は心筋細胞死を介して心筋リモデリングを増悪する2014
- Author(s)
  舎川洸太, 松浪佐知, 土山大介, 中山博之, 藤尾慈
- Organizer
  第87回日本薬理学会年会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-23390057
[Presentation] Caveolae- specific phosphorylation of L-type calcium channel b2a subunit exaggerates cardiac hypertrophic responses after a1 adrenergic stimulation in mice2014
- Author(s)
  Hiroyuki Nakayama
- Organizer
  American Heart Association
- Place of Presentation
  Las Vegas
- Data Source
  KAKENHI-PROJECT-23390212
[Presentation] マクロファージ特異的なCD93 過剰発現による死細胞貪食の増強は心筋梗塞後の心筋線維化を抑制する2014
- Author(s)
  竹脇佳那, 山下朋美, 宮本香織, 毛利友美, 中山博之, 藤尾慈
- Organizer
  第87回日本薬理学会年会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-23390057
[Presentation] Phosphorylation of L-type Ca2+ channel b2a subunit induces cardiomyocyte hypertrophy2014
- Author(s)
  Nao Hyamizu, Shohei Kumagai, Sachi Matsunami, Hiroyuki Nakayama, Yasushi Fujio
- Organizer
  日本薬理学会
- Place of Presentation
  仙台国際センター（仙台）
- Data Source
  KAKENHI-PROJECT-23390212
[Presentation] Inhibition of P2X7 Receptor Signaling Promotes Adverse Cardiac Remodeling after Myocardial Infarction through Enhanced Cardiac Fibroblast Migration2013
- Author(s)
  Kumagai Shohei, Nakayama Hiroyuki, Miyawaki Akimitsu, Mohri Tomomi, Fujio Yasushi,
- Organizer
  American Heart Association
- Place of Presentation
  ダラス
- Data Source
  KAKENHI-PROJECT-23390212
[Presentation] マクロファージによる死細胞貪食は心筋梗塞後の病態形成を抑制する2013
- Author(s)
  竹脇佳那, 宮本香織, 尾花理徳, 山下朋美, 毛利友美, 中山博之, 藤尾慈
- Organizer
  第124回日本薬理学会近畿部会
- Place of Presentation
  京都
- Year and Date
  2013-11-01
- Data Source
  KAKENHI-PROJECT-23390057
[Presentation] CD4+CD25+ regulatory T cells (Treg cells) migrate into hearts in experimental autoimmune myocarditis (EAM)2013
- Author(s)
  鳥居里衣, 山下朋美, 古谷知佳, 中山博之, 藤尾慈
- Organizer
  第86回日本薬理学会年会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23390057
[Presentation] Inhibition of P2X7 Receptor Signaling Promotes Adverse Cardiac Remodeling after Myocardial Infarction through Enhanced Cardiac Fibroblast Migration2013
- Author(s)
  Shohei Kumagai, Hiroyuki Nakayama, Akimitsu Miyawaki, Tomomi Mohri, Yasushi Fujio
- Organizer
  American Heart Association Scientific Sessions 2013
- Place of Presentation
  Dallas, Texas, USA
- Data Source
  KAKENHI-PROJECT-23390057
[Presentation] The myocardial activation of CaMKIIβ leads to heart failure2013
- Author(s)
  輪島こまゆ, 中山博之, 濱谷辰斗, 松浪佐知, 熊谷渉平, 山下朋美, 藤尾慈
- Organizer
  第86回日本薬理学会年会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23390057
[Presentation] Development of a novel tool for analysis of PKA and CaMKII activities in caveolae microdomain2013
- Author(s)
  松浪佐知, 早水菜穂, 中山博之, 藤尾慈
- Organizer
  第86回日本薬理学会年会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23390057
[Presentation] Deficiency of P2X7 receptor signaling promotes adverse cardiac remodeling after myocardial infarction through enhanced cardiac fibroblast migration2013
- Author(s)
  熊谷渉平, 中山博之, 宮脇昭光, 毛利友美, 藤尾慈
- Organizer
  第21回日本血管生物医学会学術集会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-23390057
[Presentation] Cathelicidin antimicrobial peptide inhibits fibroblasts migration via P2X7 receptor signaling2013
- Author(s)
  熊谷渉平, 中山博之, 松井一樹, 川口晴世, 宮脇昭光, 山下朋美, 藤尾慈
- Organizer
  第86回日本薬理学会年会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23390057
[Presentation] 新規ミトコンドリア融合阻害因子MIFIの心筋特異的過剰発現マウスを用いた生理・病態機能解析2013
- Author(s)
  開菜摘, 新谷紀人 , 東信太朗, 舎川洸太, 中山博之, 藤尾慈, 　井上直紀, 田中翔太, 笠井淳司, 早田敦子, 馬場明道, 橋本均
- Organizer
  第124回日本薬理学会近畿部会
- Place of Presentation
  京都ガーデンパレス（京都）
- Data Source
  KAKENHI-PROJECT-25670387
[Presentation] Regulatory T cells (Tregs) ameliorate myocardial infarction (MI)-induced cardiac remodeling in mice2013
- Author(s)
  多賀詩織, 山下朋美, 中山博之, 藤尾慈
- Organizer
  第86回日本薬理学会年会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23390057
[Presentation] Inhibition of P2X7 receptor signaling promotes adverse cardiac remodeling after myocardial infarction through enhanced cardiac fibroblast migration2013
- Author(s)
  熊谷渉平　中山博之　宮脇昭光　毛利友美　藤尾慈
- Organizer
  日本血管生物医学会
- Place of Presentation
  千里国際阪急ホテル（大阪）
- Data Source
  KAKENHI-PROJECT-23390212
[Presentation] Inhibition of P2X7 Receptor Signaling Promotes Adverse Cardiac Remodeling after Myocardial Infarction through Enhanced Cardiac Fibroblast Migration2013
- Author(s)
  Kumagai, S., Nakayama, H., Miyawaki, A., Mohri, T., Fujio, Y
- Organizer
  The American Heart Association Scientific Sessions 2013
- Place of Presentation
  Dallas, Texas, USA
- Data Source
  KAKENHI-PROJECT-23390057
[Presentation] 虚血再灌流障害に対するIL-11 のpost-conditioning 効果は心筋STAT3 を介する2012
- Author(s)
  宮本香織, 尾花理徳, 前田真貴子, 中山博之, 藤尾慈
- Organizer
  第87回日本薬理学会年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23390057
[Presentation] The ablation of RORγt gene results in advanced cardiac fibrosis after myocardial infarction2012
- Author(s)
  山下朋美, 尾花理徳, 端山明子, 中山博之, 藤尾慈
- Organizer
  第87回日本薬理学会年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23390057
[Presentation] Cardiac-specific overexpression of Runx2 mediates cardiac hypertrophy and dysfunction in mice2012
- Author(s)
  中山　博之
- Organizer
  American Heart Association Basic Cardiovascular Conference
- Place of Presentation
  New Orleans
- Data Source
  KAKENHI-PROJECT-23659110
[Presentation] Treg is Recruited into Myocardium through Th17 Pathway as a Negative Feedback in Autoimmune Myocarditis2012
- Author(s)
  Yamashita, T., Torii, R., Komuro, I., Nakayama, H., Fujio, Y
- Organizer
  The American Heart Association Scientific Sessions 2012
- Place of Presentation
  Los Angeles, California, USA
- Data Source
  KAKENHI-PROJECT-23390057
[Presentation] Calcium-mediated pathogenesis in heart2012
- Author(s)
  中山　博之
- Organizer
  日本薬理学会年回
- Place of Presentation
  京都
- Invited
- Data Source
  KAKENHI-PROJECT-23390212
[Presentation] 実験的自己免疫性心筋炎におけるTSG-6 の役割の検討2012
- Author(s)
  川口晴世, 山下朋美, 鳥居里衣, 中山博之, 藤尾慈
- Organizer
  第87回日本薬理学会年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23390057
[Presentation] オートファジーを免れたミトコンドリアDNAの蓄積は心臓において炎症と心不全を惹起する2012
- Author(s)
  中山博之
- Organizer
  第85回　日本生化学会大会
- Place of Presentation
  福岡
- Invited
- Data Source
  KAKENHI-PROJECT-23390212
[Presentation] 心筋特異的Runx2 過剰発現マウスは心肥大を惹起する2012
- Author(s)
  濱谷辰斗, 中山博之, 松浪佐知, 松尾玲男, 藤尾慈
- Organizer
  第87回日本薬理学会年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23390057
[Presentation] Cardiac-specific Overexpression of Runx2 Mediates Cardiac Hypertrophy and Dysfunction in Mice2012
- Author(s)
  Nakayama, H., Hamatani, T., Kumagai, S., Tonegawa, K., Yamashita, T., Fujio, Y
- Organizer
  Basic Cardiovascular Sciences 2012 Scientific Sessions
- Place of Presentation
  New Orleans, Louisiana, USA
- Data Source
  KAKENHI-PROJECT-23390057
[Presentation] 心筋特異的 Runx2 過剰発現マウスは心肥大を惹起する2012
- Author(s)
  濱谷辰斗、中山博之、松浪佐知、松尾玲男、藤尾慈
- Organizer
  第85回日本薬理学会年会
- Place of Presentation
  京都国際会議場(京都府)
- Year and Date
  2012-03-15
- Data Source
  KAKENHI-PROJECT-23659110
[Presentation] Cathelicidin Antimicrobial Peptide Is Upregulated after Myocarditis and Inhibits Fibroblast Migration via P2x7 Receptor Signaling2011
- Author(s)
  Nakayama, H., Matsui, K., Yamashita, T., Kawaguchi, H., Fujio, Y
- Organizer
  Basic Cardiovascular Sciences 2011 Scientific Sessions
- Place of Presentation
  New Orleans, Louisiana, USA
- Data Source
  KAKENHI-PROJECT-23390057
[Presentation] Th17 Cells Are Indispensable for Cardiac Inflammation in Autoimmune Myocarditis2011
- Author(s)
  Yamashita, Nakayama, H., Fujio, Y
- Organizer
  Basic Cardiovascular Sciences 2011 Scientific Sessions
- Place of Presentation
  New Orleans, Louisiana, USA
- Data Source
  KAKENHI-PROJECT-23390057
[Presentation] Th17 Cells Exhibit Protective Effects against Cardiac Fibrosis after Myocardial Infarction2011
- Author(s)
  Yamashita, T., Obana, M., Hayama, A., Iwakura, T., Komuro, I., Nakayama, H., Fujio, Y
- Organizer
  The American Heart Association Scientific Sessions 2011
- Place of Presentation
  Orlando, Florida, USA
- Data Source
  KAKENHI-PROJECT-23390057
[Presentation] Cathelicidin antimicrobial peptide is up-regulated after myocarditis and inhibits fibroblasts migration via P2X7 receptor signaling2011
- Author(s)
  中山博之, 松井一樹, 川口晴世, 藤尾慈
- Organizer
  第2回Molecular Cardiovascular Conference II
- Place of Presentation
  北海道
- Data Source
  KAKENHI-PROJECT-23390057
[Presentation] Inhibition of Inositol (1,4,5)-trisphosphate Signaling in the Mouse Heart attenuates Cardiac Hypertrophy after GPCR Stimulation.2010
- Author(s)
  中山博之
- Organizer
  American Heart Association Scientific Session
- Place of Presentation
  Chicago (USA)
- Year and Date
  2010-11-15
- Data Source
  KAKENHI-PROJECT-22890105
[Presentation] Calcium Mediated Pathogenesis in Heart2010
- Author(s)
  中山博之
- Organizer
  Cutting Edge Forum
- Place of Presentation
  大阪(招待講演)
- Year and Date
  2010-11-05
- Data Source
  KAKENHI-PROJECT-22890105
[Presentation] Calcium Mediated Cell Death in Heart Failure2010
- Author(s)
  中山博之
- Organizer
  第14回日本心不全学会
- Place of Presentation
  東京(招待講演)
- Year and Date
  2010-10-07
- Data Source
  KAKENHI-PROJECT-22890105
[Presentation] Caveolae-specific phosphorylation of L-type calcium channel beta2a subunit excerbates cardiac hypertrophy
- Author(s)
  Shohei Kumagai, Hiroyuki Nakayama, Nao Hayamizu, Wataru Otsuka, Yasushi Fujio
- Organizer
  American Heart Association, Scientific Sessions 2014
- Place of Presentation
  Chicago, USA
- Year and Date
  2014-11-15 – 2014-11-19
- Data Source
  KAKENHI-PROJECT-26293054
[Presentation] Elucidation of molecular mechanism of cardiomyocyte necrosis induced by reactive oxygen species.
- Author(s)
  土山大介、中山博之、森原啓文、石田瑛子、尾花理徳、前田真貴子、藤尾慈
- Organizer
  第88回日本薬理学会年会
- Place of Presentation
  名古屋
- Year and Date
  2015-03-18 – 2015-03-20
- Data Source
  KAKENHI-PROJECT-26293054
[Presentation] Adrenergic receptors β2 and β3 transduce differential signalsin cardiac fibroblasts.
- Author(s)
  五十嵐裕美、中山博之、松浪佐知、早水菜穂、舎川洸太、尾花理徳、前田真貴子、藤尾慈
- Organizer
  第88回日本薬理学会年会
- Place of Presentation
  名古屋
- Year and Date
  2015-03-18 – 2015-03-20
- Data Source
  KAKENHI-PROJECT-26293054
[Presentation] The properties of cardiac Sca-1+ resident stem cells are altered in response to myocardial inflammation.
- Author(s)
  松原由実、宮脇昭光、榎原正貴、尾花理徳、前田真貴子、中山博之、藤尾慈
- Organizer
  第88回日本薬理学会年会
- Place of Presentation
  名古屋
- Year and Date
  2015-03-18 – 2015-03-20
- Data Source
  KAKENHI-PROJECT-26293054
[Presentation] Cardiac-specific overexpression of Runx2 mediates cardiac hypertrophy and dysfunction in mice
- Author(s)
  中山博之、濱谷辰斗、熊谷渉平、舎川洸太、山下朋美、藤尾慈
- Organizer
  American Heart Association, Basic Cardiovascular Sciences 2012
- Place of Presentation
  (New Orleans, USA
- Data Source
  KAKENHI-PROJECT-23659110
[Presentation] Caveolae-specific phosphorylation of L-type calcium channel b2a subunit exaggerates cardiac hypertrophic responses after a1 adrenergic stimulation in mice
- Author(s)
  Hiroyuki Nakayama, Shohei Kumagai, Sachi Matsunami, Nao Hayamizu, Kota Tonegawa, Wataru Otsuka, Yasushi Fujio
- Organizer
  International Society of Heart Research 日本部会総会
- Place of Presentation
  名古屋
- Year and Date
  2014-11-28 – 2014-11-29
- Data Source
  KAKENHI-PROJECT-26293054
[Presentation] IL-27 negatively regulates murine experimental autoimmune myocarditis (EAM).
- Author(s)
  古谷知佳、宮脇昭光、大谷勇太、尾花理徳、前田真貴子、中山博之、藤尾慈
- Organizer
  第88回日本薬理学会年会
- Place of Presentation
  名古屋
- Year and Date
  2015-03-18 – 2015-03-20
- Data Source
  KAKENHI-PROJECT-26293054
[Presentation] Caveolae-specific phosphorylation of L-type calcium channel b2a subunit exaggerates cardiac hypertrophic responses after a1 adrenergic stimulation in mice.
- Author(s)
  Hiroyuki Nakayama, Shohei Kumagai, Sachi　Matsunami, Nao Hayamizu, Kota Tonegawa, Wataru Otsuka , Yasushi Fujio
- Organizer
  American Heart Association, Basic Cardiovascular Sciences
- Place of Presentation
  Las Vegas, USA
- Year and Date
  2014-07-13 – 2014-07-18
- Data Source
  KAKENHI-PROJECT-26293054
[Presentation] Interleukin 27 induces endothelial differentiation in murine cardiac stem cells
- Author(s)
  田中智大、尾花理徳、前田真貴子、中山博之、藤尾慈
- Organizer
  第88回日本薬理学会年会
- Place of Presentation
  名古屋
- Year and Date
  2015-03-18 – 2015-03-20
- Data Source
  KAKENHI-PROJECT-26293054

1. FUJIO Yasushi (20359839)

# of Collaborated Projects: 5 results

# of Collaborated Products: 84 results
2. ASAHI Michio (10397614)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
3. 種池学 (30609756)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
4. NAKAOKA Yoshikazu (90393214)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. Azuma Naoto (40231914)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. SHINTANI Norihito (10335367)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
7. 毛利友美 (20572960)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
8. 仲哲治 (30303936)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
9. 尾花理徳 (50745883)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
10. 前田真貴子 (70461168)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
11. 村川智一 (50902194)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. Ii Masaaki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. Nakagawa Takatoshi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. Moriwaki Kazumasa

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
15. Ai Tomohiko

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
16. NONEN Shinpei

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. YAMAGUCHI Osamu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 深田宗一朗

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 大津欣也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

nakayama hiroyuki 中山 博之

NAKAYAMA Hiroyuki 中山 博之

Research Projects

Research Products

Co-Researchers

マイトファジー関連蛋白質の虚血心における役割の解明及び創薬への基礎的検討Principal Investigator

Principal Investigator

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Review Section

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心筋細胞内β受容体リサイクリング機構の解明と心不全創薬への応用Principal Investigator

Principal Investigator

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Review Section

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Molecular mechanisms of cell proliferation of adult mammalian cardiomyocytes

Principal Investigator

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Review Section

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The role of beta adrenergic signaling in fibroblasts during cardiac senescencePrincipal Investigator

Principal Investigator

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The role of leucine-rich alpha2 glycoprotein in cardiac remodelingPrincipal Investigator

Principal Investigator

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The molecular and cellular mechanism of myocardial repair/regeneration

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Role of glycosylation on the functions of cardiac calcium regulating proteins and ion channels

Principal Investigator

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The functional role of mitochondria innermembrane fusion inhibitor in heartPrincipal Investigator

Principal Investigator

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Myocardial inflammation of heart failure as a novel therapeutic target

Principal Investigator

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Regulation of L-type calcium channel by intracellular subunit in cardiac hypertrophy and failure.Principal Investigator

Principal Investigator

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The transcriptional regulation of calcium induced cell death in heartPrincipal Investigator

Principal Investigator

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心不全におけるイノシトール三リン酸受容体の病態的意義の解明Principal Investigator

Principal Investigator

Project Period (FY)

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Research Institution

[Book] 臨床薬理学2017

Author(s)

Total Pages

nakayama hiroyuki 中山博之

NAKAYAMA Hiroyuki 中山博之

[Book] 遺伝子医学MOOK別冊細胞死研究の今　–疾患との関わり、創薬に向けてのアプローチ−2013