Mizuguchi Mariko 水口真理子

Researcher Number	40581541
Other IDs
Affiliation (Current)	2025: 麻布大学, 生命・環境科学部, 准教授
Affiliation (based on the past Project Information) *help	2024: 麻布大学, 生命・環境科学部, 准教授 2017 – 2022: 琉球大学, 医学(系)研究科(研究院), 助教
Review Section/Research Field	Principal Investigator Basic Section 54010:Hematology and medical oncology-related / Tumor biology
Keywords	Principal Investigator ATL / HTLV-1 / Foxp3 / FOXP3 / OX40L / OX40 / DNA複製

リンパ節に局在するATL細胞の増殖機構の解明Principal Investigator
- Principal Investigator
  
  水口真理子
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Azabu University
Roles of OX40/OX40L in ATLPrincipal Investigator
- Principal Investigator
  
  Mizuguchi Mariko
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  University of the Ryukyus
Mechanisms of aberrant DNA replication in adult T-cell leukemia/lymphomaPrincipal Investigator
- Principal Investigator
  
  Mizuguchi Mariko
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor biology
- Research Institution
  University of the Ryukyus

All 2022 2021 2020 2019 2018 2017

All Journal Article Presentation

[Journal Article] A protective role of HTLV-1 gp46-specific neutralizing and antibody-dependent cellular cytotoxicity-inducing antibodies in progression to adult T-cell leukemia (ATL)2022
- Author(s)
  Tanaka Yuetsu、Tanaka Reiko、Imaizumi Naoki、Mizuguchi Mariko、Takahashi Yoshiaki、Hayashi Masaki、Miyagi Takashi、Uchihara Junnosuke、Ohshiro Kazuiku、Masuzaki Hiroaki、Fukushima Takuya
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 13 Pages: 1-9
- DOI
  10.3389/fimmu.2022.921606
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08912, KAKENHI-PROJECT-19K08843
[Journal Article] Elevation of the Plasma Levels of TNF Receptor 2 in Association with Those of CD25, OX40, and IL-10 and HTLV-1 Proviral Load in Acute Adult T-Cell Leukemia2022
- Author(s)
  Megumi Kato, Naoki Imaizumi, Reiko Tanaka, Mariko Mizuguchi, Masaki Hayashi, Takashi Miyagi, Junnosuke Uchihara, Kazuiku Ohshiro, Junpei Todoroki, Kennosuke Karube, Hiroaki Masuzaki, Yuetsu Tanaka, Takuya Fukushima
- Journal Title
  
  Viruses
  
  Volume: 14 Issue: 4 Pages: 751-751
- DOI
  10.3390/v14040751
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08843, KAKENHI-PROJECT-20K08912
[Journal Article] Acute type adult T-cell leukemia cells proliferate in the lymph nodes rather than in peripheral blood2022
- Author(s)
  Mariko Mizuguchi, Mitsuyoshi Takatori, Shugo Sakihama, Manami Yoshita-Takahashi, Naoki Imaizumi, Yoshiaki Takahashi, Hiroo Hasegawa, Kennosuke Karube, Takuya Fukushima, Masataka Nakamura, Yuetsu Tanaka
- Journal Title
  
  Cancer Gene Therapy
  
  Volume: - Issue: 11 Pages: 1570-1577
- DOI
  10.1038/s41417-022-00475-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08843, KAKENHI-PROJECT-23K24233
[Journal Article] Promoter CpG methylation inhibits Kr?ppel-like factor 2 (KLF2)-Mediated repression of hTERT gene expression in human T-cells2021
- Author(s)
  Mizuguchi Mariko、Hara Toshifumi、Yoshita-Takahashi Manami、Kohda Takashi、Tanaka Yuetsu、Nakamura Masataka
- Journal Title
  
  Biochemistry and Biophysics Reports
  
  Volume: 26 Pages: 100984-100984
- DOI
  10.1016/j.bbrep.2021.100984
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07698, KAKENHI-PROJECT-19K08843
[Journal Article] Conservation of a Neutralization Epitope of Human T-cell Leukemia Virus Type 1 (HTLV-1) among Currently Endemic Clinical Isolates in Okinawa, Japan2020
- Author(s)
  Mizuguchi M, Takahashi Y, Tanaka R, Fukushima T, Tanaka Y.
- Journal Title
  
  Pathogens
  
  Volume: 9 Issue: 2 Pages: 82-82
- DOI
  10.3390/pathogens9020082
- NAID
  120006937798
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08843, KAKENHI-PROJECT-19K10602
[Journal Article] ER-resident sensor PERK is essential for mitochondrial thermogenesis in brown adipose tissue.2020
- Author(s)
  Kato H, Okabe K, Miyake M, Hattori K, Fukaya T, Tanimoto K, Beini S, Mizuguchi M, Torii S, Arakawa S, Ono M, Saito Y, Sugiyama T, Funatsu T, Sato K, Shimizu S, Oyadomari S, Ichijo H, Kadowaki H, Nishitoh H.
- Journal Title
  
  Life science alliance
  
  Volume: 3 Issue: 3 Pages: 201900576-201900576
- DOI
  10.26508/lsa.201900576
- NAID
  120006980545
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06210, KAKENHI-PROJECT-18K06222, KAKENHI-PROJECT-19K08843, KAKENHI-PLANNED-15H05931, KAKENHI-PLANNED-17H06414, KAKENHI-PLANNED-17H06419, KAKENHI-PUBLICLY-18H04699, KAKENHI-PROJECT-17H01533, KAKENHI-PROJECT-18H02973, KAKENHI-PROJECT-19H02853, KAKENHI-PROJECT-17K09862, KAKENHI-PROJECT-18K06916, KAKENHI-PROJECT-18K19469, KAKENHI-PROJECT-20K07353, KAKENHI-PROJECT-18H03995, KAKENHI-PUBLICLY-20H05314, KAKENHI-ORGANIZER-17H06413
[Presentation] ATL感染病態進行に対する抗HTLV-1 gp46中和およびADCC抗体の制御的役割.2022
- Author(s)
  田中勇悦, 田中礼子, 今泉直樹, 水口真理子, 高橋良明, 福島卓也
- Organizer
  第8回日本HTLV-1学会
- Data Source
  KAKENHI-PROJECT-19K08843
[Presentation] ATLにおけるOX40/OX40Lの役割.2022
- Author(s)
  水口真理子, 高橋良明, 田中礼子, 今泉直樹, 山下暁朗, 福島卓也, 田中勇悦
- Organizer
  第8回日本HTLV-1学会
- Data Source
  KAKENHI-PROJECT-19K08843
[Presentation] 拡大培養NK細胞とヒト化HTLV-1中和単クロン抗体を介したADCCによる自家HTLV-1産生細胞の駆逐.2021
- Author(s)
  田中勇悦, 田中礼子, 水口真理子, 高橋良明, 浦野恵美子, 保富康宏, 福島卓也
- Organizer
  第7回日本HTLV-1学術集会
- Data Source
  KAKENHI-PROJECT-19K08843
[Presentation] 急性型ATL患者の末梢ATL細胞は増殖しない.2021
- Author(s)
  水口真理子, 高鳥光徳, 崎浜秀悟, 髙橋真奈美, 今泉直樹, 高橋良明, 長谷川寛雄, 加留部謙之輔, 福島卓也, 中村正孝, 田中勇悦
- Organizer
  第7回日本HTLV-1学術集会
- Data Source
  KAKENHI-PROJECT-19K08843
[Presentation] ATLバイオマーカーとしての可溶性TNF受容体2型抗原：可溶性CD25・OX40量との相関性と自然免疫系からの放出.2021
- Author(s)
  加藤愛美, 田中礼子, 水口真理子, 今泉直樹,田中勇悦, 福島卓也
- Organizer
  第7回日本HTLV-1学術集会
- Data Source
  KAKENHI-PROJECT-19K08843
[Presentation] 新規HTLV-1中和モノクローナル抗体の作製.2021
- Author(s)
  高橋良明, 志田壽利, 宮城拓也, 田中礼子, 水口真理子, 田中勇悦
- Organizer
  第7回日本HTLV-1学術集会
- Data Source
  KAKENHI-PROJECT-19K08843
[Presentation] 新規HTLV-1エンベロープ高発現型組換え弱毒ワクシニアウイルスによるHTLV-1中和抗体の誘導2019
- Author(s)
  高橋良明、志田壽利、田中礼子、水口真理子、田中勇悦
- Organizer
  第6回日本HTLV-1学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08843
[Presentation] ウサギ胸腺細胞の顕著なHTLV-1感染感受性：ウサギ化マウスの作出に向けて2019
- Author(s)
  田中礼子、水口真理子、高橋良明、田中勇悦
- Organizer
  第6回日本HTLV-1学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08843
[Presentation] HTLV-1母子感染予防ワクチン開発への挑戦2019
- Author(s)
  田中礼子、水口真理子、高橋良明、田中勇悦
- Organizer
  第72回日本細菌学会九州支部総会　第56回日本ウイルス学会九州支部総会
- Data Source
  KAKENHI-PROJECT-19K08843
[Presentation] HTLV-1感染細胞におけるKruppel-like factor 2（KLF2）を介したhTERT遺伝子の発現制御機構2019
- Author(s)
  水口真理子、原敏文、高橋真奈美、幸田尚、田中勇悦、福島卓也、中村正孝
- Organizer
  第72回日本細菌学会九州支部総会　第56回日本ウイルス学会九州支部総会
- Data Source
  KAKENHI-PROJECT-19K08843
[Presentation] ヒトT細胞白血病ウイルス（HTLV-1）臨床分離株における広域中和エピトープの保存2019
- Author(s)
  水口真理子、高橋良明、田中礼子、福島卓也、田中勇悦
- Organizer
  第6回日本HTLV-1学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08843
[Presentation] HTLV-1感染後のPBMCにおける抗HTLV-1中和単クロン抗体による感染制御2019
- Author(s)
  田中勇悦、田中礼子、水口真理子、高橋良明
- Organizer
  第6回日本HTLV-1学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08843
[Presentation] ATL白血病細胞の多くはFoxP3抗原を発現する2018
- Author(s)
  田中　勇悦、高橋　良明、水口　真理子、田中　礼子、福島　卓也
- Organizer
  第5回日本HTLV-1学会学術集会
- Data Source
  KAKENHI-PROJECT-17K14988
[Presentation] 抗体を介したマクロファージによるHTLV-1感染制御2018
- Author(s)
  高橋　良明、清水　衡、宮城　拓也、水口　真理子、田中　礼子、田中　勇悦
- Organizer
  第5回日本HTLV-1学会学術集会
- Data Source
  KAKENHI-PROJECT-17K14988
[Presentation] HTLV-1 TaxによるDNA複製異常誘導機構の解析2018
- Author(s)
  水口　真理子、中村　正孝、高橋　良明、田中　礼子、田中　勇悦
- Organizer
  第5回日本HTLV-1学会学術集会
- Data Source
  KAKENHI-PROJECT-17K14988
[Presentation] HTLV-1感染防御ヒト単クロン抗体の作出の試み：1細胞単離ロボットの応用2018
- Author(s)
  田中　礼子、高橋　良明、水口　真理子、福島　卓也、立松　健司、黒田　俊一、田中　勇悦
- Organizer
  第5回日本HTLV-1学会学術集会
- Data Source
  KAKENHI-PROJECT-17K14988
[Presentation] HTLV-1感染細胞におけるhTERT遺伝子の発現制御機構の解析2017
- Author(s)
  水口　真理子、原　敏文、高橋　真奈美、田中　勇悦、福島　卓也、中村　正孝
- Organizer
  第4回日本HTLV-1学会学術集会
- Data Source
  KAKENHI-PROJECT-17K14988

1. 田中勇悦 (30163588)

# of Collaborated Projects: 1 results

# of Collaborated Products: 15 results
2. 福島卓也 (40336160)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 山岸誠 (90625261)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. TORII Satoru

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 益崎裕章

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 原敏文

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Mizuguchi Mariko 水口 真理子

Research Projects

Research Products

Co-Researchers

リンパ節に局在するATL細胞の増殖機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Roles of OX40/OX40L in ATLPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mechanisms of aberrant DNA replication in adult T-cell leukemia/lymphomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] A protective role of HTLV-1 gp46-specific neutralizing and antibody-dependent cellular cytotoxicity-inducing antibodies in progression to adult T-cell leukemia (ATL)2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Elevation of the Plasma Levels of TNF Receptor 2 in Association with Those of CD25, OX40, and IL-10 and HTLV-1 Proviral Load in Acute Adult T-Cell Leukemia2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Acute type adult T-cell leukemia cells proliferate in the lymph nodes rather than in peripheral blood2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Promoter CpG methylation inhibits Kr?ppel-like factor 2 (KLF2)-Mediated repression of hTERT gene expression in human T-cells2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Conservation of a Neutralization Epitope of Human T-cell Leukemia Virus Type 1 (HTLV-1) among Currently Endemic Clinical Isolates in Okinawa, Japan2020

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] ER-resident sensor PERK is essential for mitochondrial thermogenesis in brown adipose tissue.2020

Author(s)

Journal Title

DOI

NAID

Data Source

[Presentation] ATL感染病態進行に対する抗HTLV-1 gp46中和およびADCC抗体の制御的役割.2022

Author(s)

Organizer

Data Source

[Presentation] ATLにおけるOX40/OX40Lの役割.2022

Author(s)

Organizer

Data Source

[Presentation] 拡大培養NK細胞とヒト化HTLV-1中和単クロン抗体を介したADCCによる自家HTLV-1産生細胞の駆逐.2021

Author(s)

Organizer

Data Source

[Presentation] 急性型ATL患者の末梢ATL細胞は増殖しない.2021

Author(s)

Organizer

Data Source

[Presentation] ATLバイオマーカーとしての可溶性TNF受容体2型抗原：可溶性CD25・OX40量との相関性と自然免疫系からの放出.2021

Author(s)

Organizer

Data Source

[Presentation] 新規HTLV-1中和モノクローナル抗体の作製.2021

Author(s)

Organizer

Data Source

[Presentation] 新規HTLV-1エンベロープ高発現型組換え弱毒ワクシニアウイルスによるHTLV-1中和抗体の誘導2019

Author(s)

Mizuguchi Mariko 水口真理子