Seino Manabu 清野学

… Alternative Names

SEINO Manabu 清野学

Less

Researcher Number	40594320
Other IDs
Affiliation (Current)	2025: 山形大学, 医学部, 講師
Affiliation (based on the past Project Information) *help	2021 – 2024: 山形大学, 医学部, 講師 2016 – 2020: 山形大学, 医学部, 助教 2015 – 2016: 山形大学, 医学部, 医員
Review Section/Research Field	Principal Investigator Obstetrics and gynecology / Basic Section 56040:Obstetrics and gynecology-related Except Principal Investigator Basic Section 56040:Obstetrics and gynecology-related / Obstetrics and gynecology
Keywords	Principal Investigator パクリタキセル / 卵巣癌 / 化学療法抵抗性 / 活性酸素種 / 治療抵抗性 / 卵巣明細胞癌 / スルファサラジン / フェロトーシス / グルタチオン / 明細胞癌 … More / アスパラギン酸 / メタボローム解析 / 化学療法耐性 / JNK / c-Jun / JNK阻害薬 / がん幹細胞 / 卵巣がん … More Except Principal Investigator 卵巣癌 / 抗がん剤耐性 / メタボローム解析 / 腹膜播種 / アミノ酸代謝 / パクリタキセル / パクリタキセル耐性 / ポリアミン経路 / 腹水 / 抗腫瘍免疫能 / 薬剤感受性 / がんの発生 / ポリアミン代謝経路 / トランスクリプトーム / オミクス解析 / ポリアミン / メタボローム / xenograftモデル / オルガノイド / PDX / アスパラギン代謝経路 / PDXオルガノイド / 抗がん剤 / 卵巣がん / circulating tumor cell / 細胞接着 / 細胞サイズ / 腫瘍形成 / 細胞膜受容体 / 細胞骨格 / RNA sequence / 腫瘍増殖 / ハニカム膜 / 生殖内分泌学 / 分子生物学 / 婦人科腫瘍学 / エストロゲン / エストロゲン受容体 / 核内受容体転写補助因子 / Ncoa6 / 転写補助因子 / 子宮内膜 / 子宮体癌 / 脱落膜化 / 子宮体部漿液性腺癌 / フェロトーシス / スルファサラジン / 子宮体部漿液性癌 Less

アミノ酸代謝リプログラミングを標的とした卵巣癌転移機構の解明と新規治療法の開発
- Principal Investigator
  
  永瀬智
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Yamagata University
Establishment of a novel therapeutic strategy for drug-resistant ovarian cancer focusing on the glutathione synthesis pathwayPrincipal Investigator
- Principal Investigator
  
  Seino Manabu
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Yamagata University
Development of Novel Therapies for Ovarian Cancer by Targeting the Polyamine Metabolic Pathway
- Principal Investigator
  
  OHTA TSUYOSHI
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Yamagata University
Development of Novel Therapeutic Methods Based on Metabolomic and Genetic Analysis for the Control of Ovarian Cancer Cachexia
- Principal Investigator
  
  Nagase Satoru
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Yamagata University
Novel therapeutic development based on metabolomic analysis to overcome the recurrent ovarian cancer with anti-cancer drug resistance
- Principal Investigator
  
  Nagase Satoru
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Yamagata University
Development of new treatment and diagnostic method for ovarian cancer using biocompatible porous membrane (honeycomb films)
- Principal Investigator
  
  OTA TSUYOSHI
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Yamagata University
Metabolomic analysis for discovering new therapeutic target of ovarian cancer cells treated with paclitaxelPrincipal Investigator
- Principal Investigator
  
  Seino Manabu
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Yamagata University
The functional analysis of the nuclear receptor coactivator-6 (Ncoa6) which may modulate the estrogen sensitivity in the human endometrium and involves in the development of endometrial cancer.
- Principal Investigator
  
  Kawagoe Jun
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Yamagata University
Development of novel therapeutic strategies based on metabolomics analysis of uterine serous carcinoma
- Principal Investigator
  
  Nagase Satoru
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Yamagata University
The study for chemoresistance of ovarian cancer to notice c-Jun signaling pathwayPrincipal Investigator
- Principal Investigator
  
  SEINO Manabu
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Yamagata University

All 2023 2022 2021 2020 2018 2017 2016 2015

All Journal Article Presentation

[Journal Article] Mechanism of Cell Death by Combined Treatment with an xCT Inhibitor and Paclitaxel: An Alternative Therapeutic Strategy for Patients with Ovarian Clear Cell Carcinoma2023
- Author(s)
  Idei Urara、Ohta Tsuyoshi、Yamatani Hizuru、Seino Manabu、Nagase Satoru
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 24 Issue: 14 Pages: 11781-11781
- DOI
  10.3390/ijms241411781
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K09440
[Journal Article] xCT inhibitor sulfasalazine depletes paclitaxel-resistant tumor cells through ferroptosis in uterine serous carcinoma.2020
- Author(s)
  Sugiyama A, Ohta T, Obata M, Takahashi K, Seino M, Nagase S.
- Journal Title
  
  Oncol Lett.
  
  Volume: 20(3) Issue: 3 Pages: 2689-2700
- DOI
  10.3892/ol.2020.11813
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09217
[Journal Article] Time-staggered inhibition of JNK effectively sensitizes chemoresistant ovarian cancer cells to cisplatin and paclitaxel2016
- Author(s)
  Seino M, Okada M, Sakaki H, Takeda H, Watarai H, Suzuki S, Seino S, Kuramoto K, Ohta T, Nagase S, Kurachi H, Kitanaka C
- Journal Title
  
  Oncology Reports
  
  Volume: 35 Issue: 1 Pages: 593-601
- DOI
  10.3892/or.2015.4377
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K20125, KAKENHI-PROJECT-26830065, KAKENHI-PROJECT-15K18437, KAKENHI-PROJECT-16K18410
[Journal Article] The novel JNK inhibitor AS602801 inhibits cancer stem cells in vitro and in vivo.2016
- Author(s)
  Okada M, Kuramoto K, Takeda H, Watarai H, Sakaki H, Seino S, Seino M, Suzuki S, Kitanaka C.
- Journal Title
  
  Oncotarget
  
  Volume: 19 Issue: 19 Pages: 27021-27032
- DOI
  10.18632/oncotarget.8395
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26830065, KAKENHI-PROJECT-15H04946, KAKENHI-PROJECT-15K18437, KAKENHI-PROJECT-15K20125, KAKENHI-PROJECT-16K07160, KAKENHI-PROJECT-16K18410
[Journal Article] GSKJ4, A Selective Jumonji H3K27 Demethylase Inhibitor, Effectively Targets Ovarian Cancer Stem Cells.2015
- Author(s)
  Sakaki H, Okada M, Kuramoto K, Takeda H, Watarai H, Suzuki S, Seino S, Seino M, Ohta T, Nagase S, Kurachi H, Kitanaka C.
- Journal Title
  
  Anticancer Res
  
  Volume: 35 Pages: 6607-6614
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K10699
[Journal Article] GSKJ4, A Selective Jumonji H3K27 Demethylase Inhhibitor, Effectively Targets Ovarian Cancer Stem Cells2015
- Author(s)
  Sakaki H, Okada M, Kuramoto K, Takeda H, Watarai H, Suzuki S, Seino S, Seino M, Ohta T, Nagase S, Kurachi H, Kitanaka C
- Journal Title
  
  Anticancer Res.
  
  Volume: 35 Pages: 6607-6614
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K20125
[Presentation] グルタチオン代謝経路阻害剤とpaclitaxelの併用による細胞死誘導機構に関する検討2023
- Author(s)
  出井麗、太田剛、伊藤泰史、堀川翔太、榊宏諭、清野学、永瀬智
- Organizer
  第75回日本産科婦人科学会学術講演会
- Data Source
  KAKENHI-PROJECT-21K09440
[Presentation] 卵巣癌の腹水メタボローム解析に関する検討2023
- Author(s)
  堀川翔太、立花由花、奥井陽介、榊宏諭、清野学、太田剛、永瀬智
- Organizer
  第75回日本産科婦人科学会学術講演会
- Data Source
  KAKENHI-PROJECT-21K09532
[Presentation] 卵巣癌の腹水メタボローム解析に関する検討2023
- Author(s)
  堀川　翔太、奥井　陽介、立花　由花、榊　宏諭、清野　学、太田　剛、永瀬　智
- Organizer
  第75回日本産科婦人科学会学術講演会
- Data Source
  KAKENHI-PROJECT-21K09532
[Presentation] メタボロミクスによる卵巣癌組織と生体試料における代謝経路に関する検討2023
- Author(s)
  太田　剛、立花　由花、堀川　翔太、奥井　陽介、榊　宏諭、清野　学、砂村　真琴、杉本　昌弘、永瀬　智
- Organizer
  第65回日本婦人科腫瘍学会学術講演会
- Data Source
  KAKENHI-PROJECT-21K09532
[Presentation] メタボロミクスによる卵巣癌組織と生体試料における代謝経路に関する検討2023
- Author(s)
  太田　剛、立花　由花、堀川　翔太、奥井　陽介、榊　宏諭、清野　学、砂村　真琴、杉本　昌弘、永瀬　智
- Organizer
  第65回日本婦人科腫瘍学会学術講演会
- Data Source
  KAKENHI-PROJECT-21K09509
[Presentation] グルタチオン代謝経路阻害剤とpaclitaxelの併用による細胞死誘導機構に関する検討2022
- Author(s)
  出井麗、太田剛、伊藤泰史、堀川翔太榊宏諭、清野学、永瀬智
- Organizer
  第74回日本産科婦人科学会学術講演会
- Data Source
  KAKENHI-PROJECT-21K09440
[Presentation] パクリタキセル長期暴露卵巣癌細胞におけるアスパラギン代謝経路に関する研究2021
- Author(s)
  鈴木百合子、清野学、太田剛、永瀬智
- Organizer
  第62回日本婦人科腫瘍学会学術講演会
- Data Source
  KAKENHI-PROJECT-18K09217
[Presentation] 卵巣癌および子宮体癌患者における酸化ストレスに関する検討2021
- Author(s)
  清野学、太田剛、永瀬智
- Organizer
  第62回日本婦人科腫瘍学会学術講演会
- Data Source
  KAKENHI-PROJECT-18K09217
[Presentation] 子宮体癌細胞株に対するスルファサラジンおよびシスプラチンの併用効果の検討2020
- Author(s)
  髙橋可菜子、太田剛、清野学、永瀬智
- Organizer
  第19回日本婦人科がん分子標的研究会
- Data Source
  KAKENHI-PROJECT-18K09217
[Presentation] xCT inhibitor sulfasalazine enhances the efficacy of cisplatin in human uterine serous carcinoma2020
- Author(s)
  Kanako Takahashi, Manabu Seino, Urara Idei, Tsuyoshi Oota, Satoru Nagase
- Organizer
  第72回日本産科婦人科学会学術講演会
- Data Source
  KAKENHI-PROJECT-18K09217
[Presentation] Low-dose paclitaxel induces asparagine synthetase expression and increases cell proliferation in ovarian cancer cells2020
- Author(s)
  Manabu Seino, Tsuyoshi Ohta, Yousuke Okui, Yuriko Suzuki, Takeshi Sudou, Satoru Nagase
- Organizer
  第72回日本産科婦人科学会学術講演会
- Data Source
  KAKENHI-PROJECT-18K09217
[Presentation] Metabolomic analysis of ovarian cancer cells treated with paclitaxel2018
- Author(s)
  Manabu Seino
- Organizer
  17th Biennial Meeting of the International Gynecologic Cancer Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16826
[Presentation] 子宮体部漿液性腺癌細胞株におけるスルファサラジンによるパクリタキセル抵抗性解除機構に関する検討2017
- Author(s)
  杉山晶子,太田剛,榊宏諭,清野学,須藤毅,永瀬智.
- Organizer
  第69回日本産科婦人科学会
- Data Source
  KAKENHI-PROJECT-15K10699
[Presentation] Metabolomic analysis of uterine serous carcinoma with acquired resistance to paclitaxel.2017
- Author(s)
  Seino M, Ohta T, Sugiyama A, Sakaki H, Sudo T, Nagase S.
- Organizer
  The 5th Biennial Meeting of Asian Society of Gynecologic Oncology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10699
[Presentation] 子宮体部漿液性癌のタキサン耐性獲得に関するメタボローム解析2017
- Author(s)
  清野学,太田剛,杉山晶子,榊宏諭,須藤毅,永瀬智.
- Organizer
  第69回日本産科婦人科学会
- Data Source
  KAKENHI-PROJECT-15K10699
[Presentation] Requirement of JNK Signaling for Self-renewal and Tumor-initiating Capacity of Ovarian Cancer Stem Cells2015
- Author(s)
  Seino M, Okada M, Shibuya K, Seino S, Suzuki S, Takeda H, Ohta T, Kurachi H, Ito K, Nagase S, Kitanaka C
- Organizer
  American Association for Cancer Research Annual Meeting
- Place of Presentation
  アメリカ（フィラデルフィア）
- Year and Date
  2015-04-21
- Data Source
  KAKENHI-PROJECT-15K20125

1. OTA TSUYOSHI (50375341)

# of Collaborated Projects: 8 results

# of Collaborated Products: 17 results
2. Nagase Satoru (00292326)

# of Collaborated Projects: 8 results

# of Collaborated Products: 17 results
3. Kawagoe Jun (60375342)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 鈴木史彦 (20400343)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. 榊宏諭 (80744458)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. WATANABE Norikazu

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. OKADA Masashi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Seino Manabu 清野 学

SEINO Manabu 清野 学

Research Projects

Research Products

Co-Researchers

アミノ酸代謝リプログラミングを標的とした卵巣癌転移機構の解明と新規治療法の開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Establishment of a novel therapeutic strategy for drug-resistant ovarian cancer focusing on the glutathione synthesis pathwayPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of Novel Therapies for Ovarian Cancer by Targeting the Polyamine Metabolic Pathway

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of Novel Therapeutic Methods Based on Metabolomic and Genetic Analysis for the Control of Ovarian Cancer Cachexia

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Novel therapeutic development based on metabolomic analysis to overcome the recurrent ovarian cancer with anti-cancer drug resistance

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of new treatment and diagnostic method for ovarian cancer using biocompatible porous membrane (honeycomb films)

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Metabolomic analysis for discovering new therapeutic target of ovarian cancer cells treated with paclitaxelPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The functional analysis of the nuclear receptor coactivator-6 (Ncoa6) which may modulate the estrogen sensitivity in the human endometrium and involves in the development of endometrial cancer.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of novel therapeutic strategies based on metabolomics analysis of uterine serous carcinoma

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The study for chemoresistance of ovarian cancer to notice c-Jun signaling pathwayPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Mechanism of Cell Death by Combined Treatment with an xCT Inhibitor and Paclitaxel: An Alternative Therapeutic Strategy for Patients with Ovarian Clear Cell Carcinoma2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] xCT inhibitor sulfasalazine depletes paclitaxel-resistant tumor cells through ferroptosis in uterine serous carcinoma.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Time-staggered inhibition of JNK effectively sensitizes chemoresistant ovarian cancer cells to cisplatin and paclitaxel2016

Author(s)

Journal Title

DOI

Data Source

Seino Manabu 清野学

SEINO Manabu 清野学

[Presentation] グルタチオン代謝経路阻害剤とpaclitaxelの併用による細胞死誘導機構に関する検討2022