Fujiwara Kyoko 藤原恭子

… Alternative Names

Researcher Number	40595708
Other IDs
Affiliation (Current)	2021: 日本大学, 歯学部, 准教授
Affiliation (based on the past Project Information) *help	2018 – 2020: 日本大学, 歯学部, 准教授 2010 – 2018: 日本大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Dermatology / Basic Section 50020:Tumor diagnostics and therapeutics-related Except Principal Investigator Pediatric surgery / Clinical oncology / Orthopaedic surgery / Tumor therapeutics / Urology / Digestive surgery / Basic Section 52020:Neurology-related / Basic Section 52040:Radiological sciences-related / Basic Section 56030:Urology-related
Keywords	Principal Investigator 皮膚有棘細胞癌 / マウスモデル / 有棘細胞癌 / ゲノムメチル化 / エピジェネティクス / ゲノムメチル化変異 / エピジェネティック変異 / ヒストン脱メチル化酵素 / 有棘細胞がん / 腫瘍関連遺伝子 … More Except Principal Investigator PIポリアミド / 腎芽腫 / 小児腫瘍学 / ピロール・イミダゾール・ポリアミド / がん / 放射線増感剤 / 肝芽腫 / 機能解析 / メチル化 / DNAメチル化 / 前立腺癌 / アンドロゲン受容体 / 融合遺伝子 / Imprinting 異常 / PI ポリアミド / 小児外科 / 小児固形腫瘍 / インプリンティング遺伝子 / ベックウィズウィードマン症候群 / E-box / MYC / 抗腫瘍効果 / Myc / 抗腫瘍薬 / ポリアミド / E-box配列 / 骨肉腫 / 光増感剤 / ポルフィリン / 細胞増殖能 / プラズマ / 癌 / ミトコンドリア / 酸化ストレス / AGP / 抗がん作用 / ミトコンドリアダイナミクス / オートファジー / カスパーゼ非依存性細胞死 / アポトーシス / アンドロゲン応答遺伝子 / アンドロゲン / ドセタキセル抵抗性 / ABHD2 / 去勢抵抗性 / 医学 / 臨床外科学 / 横紋筋肉腫 / CBI / 肝内胆管癌 / ChB-PIP / アルキル化剤 / 神経芽腫 / DFAT / 分化誘導 / BDNF / 分化誘導療法 / 脱分化脂肪細胞 / RET / Transglutaminase 2 / 分化 / 間葉系幹細胞 / 自己免疫性脳炎 / 神経細胞表面抗体 / パスウェイ解析 / マイクロアレイ / 創薬 / 低酸素細胞 / ピロール・イミダゾールポリアミド(PIP) / ピロールイミダゾールポリアミド Less

Molecular approaches to identify the novel therapeutic targets for the encephalitis associated with neuronal surface antibodies
- Principal Investigator
  
  原誠
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Nihon University
PIポリアミドによる低酸素細胞に対する放射線増感剤の開発
- Principal Investigator
  
  石橋直也
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  Nihon University
去勢抵抗性前立腺がんのアンドロゲン受容体転写協調因子を標的としたポリアミド創薬
- Principal Investigator
  
  高橋悟
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Nihon University
糸状菌由来ポリエチレングリコール誘導体による腫瘍特異的な細胞障害性の機序の解明Principal Investigator
- Principal Investigator
  
  藤原恭子
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Nihon University
Development of the alkylating agent targeting intrahepatic cholangiocarcinoma -specific fusion gene
- Principal Investigator
  
  TAKAGI Keiko
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Nihon University
Examination of differentiation induction new therapy using DFAT in human neuroblastoma
- Principal Investigator
  
  KANEDA Hide
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatric surgery
- Research Institution
  Nihon University
Mechanistic study on tumor-selective killing by plasma
- Principal Investigator
  
  SOMA Masayoshi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor therapeutics
- Research Institution
  Nihon University
Searching for human SCC related gene aberrations by using Gasc1 knockout micePrincipal Investigator
- Principal Investigator
  
  FUJIWARA Kyoko
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Nihon University
The elucidation on androgen signaling pathway in prostate cancer and development of its targeting drug
- Principal Investigator
  
  TAKAHASHI Satoru
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Nihon University
Anti-tumor effect of alkylating pyrrole-imidazole polyamide targeting rhabdomyosarcoma specific fusion gene PAX3-FOXO1
- Principal Investigator
  
  FURUYA Takeshi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatric surgery
- Research Institution
  Nihon University
Analaysys of tumor-associated genes in human pediatric liver tumor and renal tumor using mice at each developmental stage
- Principal Investigator
  
  SUGITO Kiminobu
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatric surgery
- Research Institution
  Nihon University
Searching for tumor associated genes of human nephroblastoma and human hepatoblastoma by analysis of tumor specific genes
- Principal Investigator
  
  KOSHINAGA Tsugumichi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatric surgery
- Research Institution
  Nihon University
Analysis of the alteracion of genome methylation level in human skin squamous cell carcinomaPrincipal Investigator
- Principal Investigator
  
  FUJIWARA Kyoko
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Nihon University
Development of new radiosensitizer for osteosarcoma
- Principal Investigator
  
  YOSHIDA Yukihiro
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Nihon University
Analysis of anti-cancer effect of PI polyamide, which suppress MYC downstream genes
- Principal Investigator
  
  SOMA Masayoshi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Clinical oncology
- Research Institution
  Nihon University
Investigation of Imprinting mechanism between Beckwith-Wiedemann syndrome and Wilms tumor
- Principal Investigator
  
  KOSHINAGA Tsugumiti
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatric surgery
- Research Institution
  Nihon University

All 2017 2016 2015 2014 2013 2012 2011 Other

All Journal Article Presentation

[Journal Article] Tumor-selective mitochondrial network collapse induced by atmospheric gas plasma-activated medium.2016
- Author(s)
  Yoshihiro Suzuki-Karasaki et al.
- Journal Title
  
  Oncotarget
  
  Volume: 6 Pages: 19910-19927
- DOI
  10.18632/oncotarget.7889
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K06883, KAKENHI-PROJECT-15K09750, KAKENHI-PROJECT-15K09792
[Journal Article] Abhydrolase domain containing 2, an androgen target gene, promotes prostate cancer cell proliferation and migration.2016
- Author(s)
  Obinata D, Takada S, Takayama K, Urano T, Ito A, Ashikari D, Fujiwara K, Yamada Y, Murata T, Kumagai J, Fujimura T, Ikeda K, Horie-Inoue K, Homma Y
- Journal Title
  
  Eur J Cancer.
  
  Volume: 57 Pages: 1853-1865
- DOI
  10.1016/j.ejca.2016.01.002
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K15353, KAKENHI-PROJECT-26293223, KAKENHI-PROJECT-15K15073, KAKENHI-PROJECT-15K10610, KAKENHI-PROJECT-15K15581, KAKENHI-PROJECT-16K15496
[Journal Article] Genome-wide screening of aberrant DNA methylation which associated with gene expression in mouse skin cancers.2015
- Author(s)
  Fujiwara K, Ghosh S, Liang P, Morien E, Soma M, Nagase H
- Journal Title
  
  Molecular Carcinogenesis.
  
  Volume: e-pub Pages: 1-11
- DOI
  10.1002/mc.22085
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23300344, KAKENHI-PROJECT-24591637, KAKENHI-ORGANIZER-25112001, KAKENHI-PUBLICLY-25134718, KAKENHI-PUBLICLY-26112517, KAKENHI-PROJECT-26290060, KAKENHI-PROJECT-26462718
[Journal Article] Inhibition of malignant phenotypes of human osteosarcoma cells by a gene silencer Pyrrole-Imidazole polyamide targeting E-box.2014
- Author(s)
  134. Taniguchi M, Nakai Y, Ozaki T, Koshikawa N, Kojima T, Kataba M, Oguni A, Matsuda H, Yoshida Y, Tokuhashi Y, Fukuda N, Ueno T, Soma T, Nagase H.
- Journal Title
  
  FEBS OPEN BIO
  
  Volume: 4 Pages: 328-334
- DOI
  10.1016/j.fob.2014.03.004
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-23300344, KAKENHI-PROJECT-23501278, KAKENHI-PROJECT-23501313, KAKENHI-PUBLICLY-25134718, KAKENHI-PUBLICLY-26112517, KAKENHI-PROJECT-26290060
[Journal Article] Inhibition of malignant phenotypes of human osteosarcoma cells by a gene silencer, a pyrrole-imidazole polyamide, which targets an E-box motif Original Research Article2014
- Author(s)
  Taniguchi M, Fujiwara K, Nakai Y, Ozaki T, Koshikawa N, Toshio K, Kataba M, Oguni A, Matsuda H, Yoshida Y, Tokuhashi Y, Fukuda N, Ueno T, Soma M, Nagase H
- Journal Title
  
  FEBS Open Bio
  
  Volume: (4) Pages: 328-334
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23501313
[Presentation] Development of pyrrole-imidazole polyamide targeting rhabdomyosarcoma2017
- Author(s)
  藤原恭子
- Organizer
  新規バイオ医薬ピロール・イミダゾール（PI）ポリアミドの創薬開発シンポジウム
- Place of Presentation
  日本大学桜門会館
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10930
[Presentation] Analysis of the role of GASC1 in development of skin tumor2016
- Author(s)
  藤原恭子、尾崎由美、照井正、永瀬浩喜、相馬正義
- Organizer
  第9回　日本大学先端バイオフォーラム
- Place of Presentation
  日本大学会館（東京都、千代田区）
- Year and Date
  2016-01-27
- Data Source
  KAKENHI-PROJECT-15K09791
[Presentation] E-box　配列認識PI ポリアミドによる抗腫瘍効果の検討2013
- Author(s)
  藤原恭子
- Organizer
  第22回　日本病態治療研究会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23501313
[Presentation] Genome-wide screening of aberrant DNA methylation which associate with gene expression in skin cancers2013
- Author(s)
  藤原恭子、相馬正義、永瀬浩喜
- Organizer
  第36回分子生物学会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-24591637
[Presentation] E-box 認識PI ポリアミドによる抗腫瘍効果の検討2013
- Author(s)
  藤原恭子
- Organizer
  第22回癌病態治療研究会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23501313
[Presentation] 抗腫瘍効果を持つE-box 認識ピロール・イミダゾール・ポリアミドの開発2013
- Author(s)
  藤原恭子、相馬正義、永瀬浩喜
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23501313
[Presentation] LIT1遺伝子を標的としたPYRROLE-IMIDAZOLE POLYAMIDE(PIP)の抗腫瘍効果の検討2013
- Author(s)
  吉澤信輔,杉藤公信,星玲奈,植草省太,川島弘之,古屋武史,金田英秀,細田利史,大橋研介,池田太郎,越永従道,藤原恭子,相馬正義,永瀬浩喜.
- Organizer
  第113回日本外科学会総会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-22591986
[Presentation] Development of a novel E-box binding PI polyamide inhibiting cell-proliferation2012
- Author(s)
  藤原恭子
- Organizer
  第二回日中がん研究シンポジウム
- Place of Presentation
  千葉
- Data Source
  KAKENHI-PROJECT-23501313
[Presentation] Inhibition of LIT1 Gene Transcriptionby Pyrrole-Imidazole Polyamide in Beckwith-Wiedemann syndrome fibroblast cell lines2012
- Author(s)
  Shinsuke Yoshizawa, Kiminobu Sugito, ShotaUekusa, Hiroyuki Kawashima, ReinaHoshi, Takeshi Furuya, Hide Kaneda, Toshifumi Hosoda, Takayuki Masuko, Taro Ikeda, Tsugumichi Koshinaga, Kyoko Fujiwara, Hiroki Nagase.
- Organizer
  44th International Society of Paediatric Oncology.
- Place of Presentation
  London,England
- Data Source
  KAKENHI-PROJECT-22591986
[Presentation] 皮膚腫瘍における発現変化を伴うゲノムDNAメチル化変異の網羅的スクリーニング2012
- Author(s)
  藤原恭子
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-24591637
[Presentation] Development of a novel E-box binding PI polyamide inhibiting cell-proliferation2012
- Author(s)
  Fujiwara K, Taniguchi M, Soma M and Nagase H
- Organizer
  第2回日中がん研究シンポジウム
- Place of Presentation
  千葉
- Data Source
  KAKENHI-PROJECT-23501313
[Presentation] Inhibition of LIT1 Gene Transcriptionby PI Polyamide(PIP) in Beckwith-Wiedemann syndrome(BWS) fibroblast cell lines2012
- Author(s)
  Shinsuke Yoshizawa, Shota Uekusa, Hiroyuki Kawashima, Kyoko Fujiwara,HirokiNagase
- Organizer
  第71回日本癌学会総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-22591986
[Presentation] Beckwith-Wiedemann症候群細胞株におけるPyrrole-Imidazole Polyamide(P-IPolyamide)によるp57^<KIP2>遺伝子の発現調節2012
- Author(s)
  吉澤信輔,杉藤公信,星玲奈,植草省太,大橋研介,池田太郎,越永従道,藤原恭子,相馬正義
- Organizer
  第49回日本小児外科学会総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22591986
[Presentation] ヒト骨肉腫におけるhTERT 遺伝子を標的とした遺伝子発現抑制薬ピロールイミダゾールポリアミドの開発2011
- Author(s)
  谷口真史、藤原恭子、永瀬浩喜、大幸俊三、吉田行弘、大幸英至、小島敏雄、徳橋泰明
- Organizer
  第26回日本整形外科学会基礎学術集会
- Place of Presentation
  群馬
- Data Source
  KAKENHI-PROJECT-23501313
[Presentation] Beckwith-Wiedemann症候群細胞株におけるPyrrole-Imidazole Polyamide(P-I Polyamide)によるp57KIP2遺伝子の発現調節2011
- Author(s)
  吉澤信輔,杉藤公信,星玲奈,植草省太,大橋研介,池田太郎,越永従道,藤原恭子,相馬正義.
- Organizer
  第53回日本小児血液・がん学会学術集会
- Place of Presentation
  前橋
- Data Source
  KAKENHI-PROJECT-22591986
[Presentation] The oncogenic role of histone demethylase Gasc1 in chemically induced mouse skin tumor
- Author(s)
  藤原恭子、秦由美、相馬正義、永瀬浩喜
- Organizer
  第７３回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜市）
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-24591637

1. KOSHINAGA Tsugumiti (70205376)

# of Collaborated Projects: 5 results

# of Collaborated Products: 4 results
2. SUGITO Kiminobu (10328750)

# of Collaborated Projects: 4 results

# of Collaborated Products: 4 results
3. FURUYA Takeshi (20568539)

# of Collaborated Projects: 4 results

# of Collaborated Products: 2 results
4. NAGASE Hiroki (90322073)

# of Collaborated Projects: 4 results

# of Collaborated Products: 9 results
5. OZAKI Toshinori (40260252)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
6. SOMA Masayoshi (30246855)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
7. FUKUDA Noboru (40267050)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
8. TERUI Tadashi (30172109)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
9. TAKAHASHI Satoru (50197141)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
10. INOUE Satoshi (40251251)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. 植草省太 (70746338)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. 大日方大亮 (20624886)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
13. OOHASHI Kensuke (10526065)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
14. UENO Takahiro (40386008)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
15. YOSHIDA Yukihiro (20201022)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. TAKAYAMA Kenichi (50508075)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
17. TAKAGI Keiko (20339328)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. KANEDA Hide (30598967)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 鈴木良弘 (80206549)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
20. 浅井朋彦 (00386004)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
21. 山口健哉 (00297813)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 浦野友彦 (20334386)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
23. 芦苅大作 (70748053)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
24. 緑川泰 (10292905)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 原誠 (10817224)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 中嶋秀人 (20330095)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. 石橋直也 (40649331)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. 渡部隆義 (60526060)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. 篠崎喜脩 (00766553)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. 西巻はるな (00834152)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. 前林俊也 (20409006)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
32. 前林亜紀 (90451369)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
33. KOSHIKAWA Nobuko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
34. 井上聰

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
35. 堀江公仁子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
36. 池田和博

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Fujiwara Kyoko 藤原 恭子

FUJIWARA Kyouko 藤原 恭子

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糸状菌由来ポリエチレングリコール誘導体による腫瘍特異的な細胞障害性の機序の解明Principal Investigator

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Searching for human SCC related gene aberrations by using Gasc1 knockout micePrincipal Investigator

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Analysis of the alteracion of genome methylation level in human skin squamous cell carcinomaPrincipal Investigator

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Fujiwara Kyoko 藤原恭子

FUJIWARA Kyouko 藤原恭子

[Presentation] E-box　配列認識PI ポリアミドによる抗腫瘍効果の検討2013