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Hikasa Hiroki  日笠 弘基

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HIKASA Hiroki  日笠 弘基

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Researcher Number 40596839
Affiliation (Current) 2025: 産業医科大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help 2017 – 2024: 産業医科大学, 医学部, 准教授
2016 – 2017: 産業医科大学, 医学部, 講師
2015: 九州大学, 生体防御医学研究所, 研究員
2011 – 2014: 九州大学, 生体防御医学研究所, 助教
Review Section/Research Field
Principal Investigator
Basic Section 48040:Medical biochemistry-related / Cell biology / Basic Section 44010:Cell biology-related / Biological Sciences
Keywords
Principal Investigator
Hippo経路 / 病態モデルマウス / IRAK1 / Wnt経路 / 炎症性シグナル / YAP/TAZ制御因子 / 慢性炎症関連疾患 / ヒト化マウス・ヒトIRAK1-Tgマウス / Wnt/β-カテニン / NFκB … More / βーカテニン / 新規シグナル軸 / 炎症性サイトカインIL-1 / シグナル因子の検索 / 活性型ヒトIRAK1発現マウスの樹立 / 慢性炎症 / 体細胞変異体 / IL1-IRAK1-β-カテニン シグナル軸 / 炎症病態モデルマウス / 作用点の解析 / YAP/TAZ制御因子の同定 / スクリーニングシステムの開発 / 生体恒常性の破綻 / Hippo経路エフェクター / 恒常性の破綻 / YAP/TAZの制御機構 / YAP/TAZ活性化機構 / Hippo経路の分子探索 / 腫瘍化と再生 / YAP/TAZ制御機構 / 組織再生 / 腫瘍化 / Hippo 経路 / 活性制御 / YAP/TAZ / YAP/TAZ活性化シグナル / YAP/TAZ阻害剤 / 国際情報交流 New York / TCF3 / 国際情報交換 / TCF / Switch mechanism / TCF proteins / HIPK2 / Wnt Less
  • Research Projects

    (6 results)
  • Research Products

    (37 results)
  • Co-Researchers

    (4 People)
  •  β-カテニンを活性化するヒトIRAK1特異的モチーフの役割と病態との関連Principal Investigator

    • Principal Investigator
      日笠 弘基
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 48040:Medical biochemistry-related
    • Research Institution
      University of Occupational and Environmental Health, Japan
  •  Novel signaling axis triggered by inflammatory cytokine IL-1 and its relation to fibrosis and cancerPrincipal Investigator

    • Principal Investigator
      Hikasa Hiroki
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 48040:Medical biochemistry-related
    • Research Institution
      University of Occupational and Environmental Health, Japan
  •  Searching for signals controlling Hippo pathway effectors YAP/TAZPrincipal Investigator

    • Principal Investigator
      Hikasa Hiroki
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 44010:Cell biology-related
    • Research Institution
      University of Occupational and Environmental Health, Japan
  •  Search for YAP/TAZ-regulating factorsPrincipal Investigator

    • Principal Investigator
      HIKASA Hiroki
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Cell biology
    • Research Institution
      University of Occupational and Environmental Health, Japan
      Kyushu University
  •  YAP/TAZ活性化細胞の同定とそれを標的にした薬剤の開発Principal Investigator

    • Principal Investigator
      日笠 弘基
    • Project Period (FY)
      2013 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      Kyushu University
  •  Regulation of HIPK2 and TCF proteins by Wnt signalingPrincipal Investigator

    • Principal Investigator
      HIKASA Hiroki
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Cell biology
    • Research Institution
      Kyushu University

All 2023 2022 2021 2020 2019 2018 2017 2016 2015 2013 2012 2011 Other

All Journal Article Presentation Book Patent

  • [Book] Wnt signaling2013

    • Author(s)
      Hikasa H and Sokol S Y
    • Total Pages
      454
    • Publisher
      CSH press
    • Data Source
      KAKENHI-PROJECT-23570235
  • [Book] Wnt signaling2013

    • Author(s)
      Hikasa H and Sokol S Y.
    • Publisher
      C.S.H.press.
    • Data Source
      KAKENHI-PROJECT-23570235
  • [Journal Article] N-(3,4-dimethoxyphenethyl)-6-methyl-2,3,4,9-tetrahydro-1H-carbazol-1-amine inhibits bladder cancer progression by suppressing YAP1/TAZ2022

    • Author(s)
      Shiraishi Y, Maehama T, Nishio M, Otani J, Hikasa H, Mak TW, Sasaki T, Honma T, Kondoh Y, Osada H, Yoshida M, Fujisawa M, Suzuki A.
    • Journal Title

      Genes Cells

      Volume: 27(10) Issue: 10 Pages: 602-612

    • DOI

      10.1111/gtc.12979

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K06830, KAKENHI-PROJECT-21H04806, KAKENHI-PROJECT-20K07590, KAKENHI-PROJECT-19H05640
  • [Journal Article] Alantolactone is a natural product that potently inhibits YAP1/TAZ through promotion of reactive oxygen species accumulation.2021

    • Author(s)
      Nakatani K, Maehama T, Nishio M, Otani J, Yamaguchi K, Fukumoto M, Hikasa H, Hagiwara S, Nishina H, Mak TW, Honma T, Kondoh Y, Osada H, Yoshida M, Suzuki A
    • Journal Title

      Cancer Science

      Volume: 112 Issue: 10 Pages: 4303-4316

    • DOI

      10.1111/cas.15079

    • NAID

      120007159906

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-18H05503, KAKENHI-PUBLICLY-20H04905, KAKENHI-PROJECT-21H04806, KAKENHI-PROJECT-20H03381, KAKENHI-PROJECT-20K07572, KAKENHI-PROJECT-20K07590, KAKENHI-PROJECT-21K06830, KAKENHI-PROJECT-20K20661, KAKENHI-PLANNED-17H06412
  • [Journal Article] YAP1 is a potent driver of the onset and progression of oral squamous cell carcinoma2020

    • Author(s)
      Omori Hirofumi、Nishio Miki、Masuda Muneyuki、Miyachi Yosuke、Ueda Fumihito、Nakano Takafumi、Sato Kuniaki、Mimori Koshi、Taguchi Kenichi、Hikasa Hiroki、Nishina Hiroshi、Tashiro Hironori、Kiyono Tohru、Mak Tak Wah、Nakao Kazuwa、Nakagawa Takashi、Maehama Tomohiko、Suzuki Akira
    • Journal Title

      Science Advances

      Volume: 6 Issue: 12 Pages: 3324-3324

    • DOI

      10.1126/sciadv.aay3324

    • NAID

      120006818745

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K06132, KAKENHI-PROJECT-18K06232, KAKENHI-PROJECT-18K08638, KAKENHI-PROJECT-17H01566, KAKENHI-PROJECT-18K15240, KAKENHI-PROJECT-20K09621, KAKENHI-PROJECT-20K20661, KAKENHI-PUBLICLY-20H05039, KAKENHI-PROJECT-17H01400, KAKENHI-PROJECT-19H03715, KAKENHI-PROJECT-20H03381
  • [Journal Article] Endogenous YAP1 activation drives immediate onset of cervical carcinoma in situ in mice.2020

    • Author(s)
      Miki Nishio , Yoko To , Tomohiko Maehama , Yukari Aono , Junji Otani , Hiroki Hikasa , Akihiro Kitagawa , Koshi Mimori , Takehiko Sasaki , Hiroshi Nishina , Shinya Toyokuni , John P Lydon , Kazuwa Nakao , Tak Wah Mak , Tohru Kiyono , Hidetaka Katabuchi , Hironori Tashiro , Akira Suzuki
    • Journal Title

      Cancer science

      Volume: 111 Issue: 10 Pages: 3576-3578

    • DOI

      10.1111/cas.14581

    • NAID

      120006892076

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K07572, KAKENHI-PROJECT-20K07590, KAKENHI-PROJECT-20K09621, KAKENHI-PROJECT-20K20661, KAKENHI-PUBLICLY-20H05039, KAKENHI-PROJECT-17H01400, KAKENHI-PROJECT-19H03715, KAKENHI-PROJECT-20H03381, KAKENHI-PROJECT-18K06132, KAKENHI-PROJECT-18K06232, KAKENHI-PROJECT-16H06276
  • [Journal Article] Hypoxia-inducible factor-1α promotes cell survival during ammonia stress response in ovarian cancer stem-like cells.2017

    • Author(s)
      Kitajima S, Lee KL, Hikasa H, Sun W, Huang RY, Yang H, Matsunaga S, Yamaguchi T, Araki M, Kato H, Poellinger L
    • Journal Title

      Oncotarget.

      Volume: 8 Issue: 70 Pages: 114481-114494

    • DOI

      10.18632/oncotarget.23010

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K07052, KAKENHI-PROJECT-16K21044
  • [Journal Article] Merlin/NF2-Lin28B-let7 is a novel tumor-suppressive pathway that is cell density-dependent and Hippo-independent2016

    • Author(s)
      Hikasa H., Sekido Y. and Suzuki A.
    • Journal Title

      Cell reports

      Volume: 14 Issue: 12 Pages: 2950-2961

    • DOI

      10.1016/j.celrep.2016.02.075

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15K07052
  • [Journal Article] Dysregulated YAP1/TAZ and TGF signaling mediate hepatocarcinogenesis in Mob1a/1b-deficient mice2015

    • Author(s)
      Nishio, M., Sugimachi, K., Goto, H., Wang, J., Morikawa, T., Miyachi, Y., Takano, Y., Hikasa, H., Itoh, T., Suzuki, S.O., Kurihara, H., Aishima, S., Leask, A., Sasaki, T., Nakano, T., Nishina, H., Nishikawa, Y., Sekido, Y., Nakao, K., Shin-ya, K., Mimori, K. and Suzuki, A.
    • Journal Title

      PNAS

      Volume: 113 Issue: 1 Pages: 71-80

    • DOI

      10.1073/pnas.1517188113

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K07052, KAKENHI-PROJECT-15K14947, KAKENHI-PROJECT-15K15107, KAKENHI-PROJECT-15K19026, KAKENHI-PLANNED-15H05899, KAKENHI-PROJECT-26253006, KAKENHI-PROJECT-15H04921, KAKENHI-PROJECT-26670396, KAKENHI-PROJECT-24390092, KAKENHI-PROJECT-15H02536, KAKENHI-PROJECT-26293012
  • [Journal Article] Wnt signaling in vertebrate axis specification2013

    • Author(s)
      Hikasa H and Sokol S Y
    • Journal Title

      Cold Spring Harbor Perspective in Biology

      Volume: 5 (1) Issue: 1 Pages: 197-216

    • DOI

      10.1101/cshperspect.a007955

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23570235
  • [Journal Article] Wnt signaling in vertebrate axis specification2013

    • Author(s)
      Hikasa H and Sokol S Y.
    • Journal Title

      Cold Spring Harbor Perspective in Biology

      Volume: 5(1)

    • Data Source
      KAKENHI-PROJECT-23570235
  • [Journal Article] Phosphorylation of TCF proteins by homeodomain-interacting protein kinase 2.2011

    • Author(s)
      Hikasa H, and Sokol SY.
    • Journal Title

      J.Biol Chem

      Volume: 286 Pages: 12093-120100

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23570235
  • [Journal Article] Phosphorylation of TCF proteins by homeodomain-interacting protein kinase 22011

    • Author(s)
      Hikasa H and Sokol S Y.
    • Journal Title

      J. Biol. Chem.

      Volume: 286(14) Pages: 12093-100

    • Data Source
      KAKENHI-PROJECT-23570235
  • [Journal Article] Regulation of the MDM2-P53 pathway and tumor growth by PICT1 via nucleolar RPL12011

    • Author(s)
      Sasaki M, Kawahara K, Nishio M, Hikasa H and Suzuki A.
    • Journal Title

      Nat. Med.

      Volume: 17(8) Pages: 994-51

    • Data Source
      KAKENHI-PROJECT-23570235
  • [Journal Article] Cancer susceptibility and embryonic lethality in Mob1A/1B double mutant mice

    • Author(s)
      Nishio M, Hikasa H and Suzuki A.
    • Journal Title

      J. Clin. Invest.

      Volume: 122(12) Pages: 4505-18

    • Data Source
      KAKENHI-PROJECT-23570235
  • [Patent] がん遺伝子産物YAP1/TAZ機能調節剤2021

    • Inventor(s)
      日笠弘基、乾雅子、上野光
    • Industrial Property Rights Holder
      日笠弘基、乾雅子、上野光
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2017-218926
    • Filing Date
      2021
    • Acquisition Date
      2022
    • Data Source
      KAKENHI-PROJECT-21K06830
  • [Patent] Wnt/β-カテニン経路の活性化亢進作用を有するタンパク質2021

    • Inventor(s)
      日笠弘基、三村恭弘、乾雅子
    • Industrial Property Rights Holder
      日笠弘基、三村恭弘、乾雅子
    • Industrial Property Rights Type
      特許
    • Filing Date
      2021
    • Acquisition Date
      2024
    • Data Source
      KAKENHI-PROJECT-21K06830
  • [Patent] Wnt/β-カテニン経路の活性化亢進作用を有するタンパク質2019

    • Inventor(s)
      日笠弘基 三村恭弘 乾雅子
    • Industrial Property Rights Holder
      日笠弘基 三村恭弘 乾雅子
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2019-207336
    • Filing Date
      2019
    • Data Source
      KAKENHI-PROJECT-18K06232
  • [Patent] がん遺伝子産物YAP1/TAZ機能調節剤2017

    • Inventor(s)
      日笠 弘基
    • Industrial Property Rights Holder
      日笠 弘基
    • Industrial Property Rights Type
      特許
    • Filing Date
      2017
    • Data Source
      KAKENHI-PROJECT-15K07052
  • [Presentation] IL-1受容体経路因子であるヒトIRAK1のβ-カテニン活性化能は、ヒト特異的モチーフに依存する。2023

    • Author(s)
      日笠弘基、三村恭弘、乾 雅子、大坪孝平、平良眞規
    • Organizer
      第46回日本生物学会
    • Data Source
      KAKENHI-PROJECT-21K06830
  • [Presentation] TLR/IL-1R経路構成因子ヒトIRAK1のマウス肺特異的過剰発現の影響解析2023

    • Author(s)
      三村 恭弘、大坪 孝平、平良 眞規、日笠 弘基
    • Organizer
      第96回生化学学会
    • Data Source
      KAKENHI-PROJECT-21K06830
  • [Presentation] Human interleukin-1 receptor-associated kinase1, a component of TLR/IL-1R pathways, activates b-catenin via its human-specific PPPSP motif.2022

    • Author(s)
      Yasuhiro Mimura, Masako Inui, Kohei Otsubo, Masanori Taira, Hiroki Hikasa*
    • Organizer
      EMBO Workshop: Wnt 2022
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K06830
  • [Presentation] IL-1受容体経路因子であるヒトIRAK1は、そのヒト特異的モチーフを介して、IL-1によるβ-カテニン経路の活性化に寄与する。2022

    • Author(s)
      日笠弘基*、三村恭弘、乾 雅子、大坪孝平、平良眞規
    • Organizer
      第45回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-21K06830
  • [Presentation] IL-1受容体経路因子であるヒトIRAK1はNFκB経路とβ-カテニン経路の同時活性化に 関与する。2021

    • Author(s)
      日笠弘基、三村恭弘、乾 雅子、大坪孝平、平良眞規
    • Organizer
      第94回生化学会
    • Data Source
      KAKENHI-PROJECT-21K06830
  • [Presentation] 多様な腫瘍で過剰発現するIL-1受容体-NFkB経路構成因子IRAK1は、Wnt/b-cateninシグナル経路を活性化する。2021

    • Author(s)
      三村恭弘、乾雅子、平良眞規、大坪孝平、日笠弘基
    • Organizer
      第44回日本分子生物学会
    • Data Source
      KAKENHI-PROJECT-21K06830
  • [Presentation] Toll様受容体/IL-1受容体経路構成因子IRAK1はPPPSPモチーフによるAxin1との相互作用を介してWnt/β-cateninシグナル経路を活性化する2020

    • Author(s)
      三村 恭弘, 乾 雅, 平良 眞規, 大坪 孝平, 日笠 弘基
    • Organizer
      第43回日本分子生物学会
    • Data Source
      KAKENHI-PROJECT-18K06232
  • [Presentation] Toll様受容体/IL-1受容体経路構成因子であるヒトIRAK1はWnt/β-カテニン経路を活性化する2019

    • Author(s)
      三村恭弘、乾雅子、山元 孝佳、大坪 孝平、平良 眞規、日笠 弘基
    • Organizer
      第42回日本分子生物学会
    • Data Source
      KAKENHI-PROJECT-18K06232
  • [Presentation] Hippo経路エフェクターYAP/TAZを制御する因子の同定2018

    • Author(s)
      日笠弘基
    • Organizer
      分子生物学会
    • Data Source
      KAKENHI-PROJECT-18K06232
  • [Presentation] Hippo経路エフェクターYAP/TAZを制御する因子の検索2017

    • Author(s)
      日笠弘基
    • Organizer
      第40回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-15K07052
  • [Presentation] Merlin regulates the biogenesis via Lin28B suppression in a cell density-dependent manner.2015

    • Author(s)
      Hikasa H., Sekido Y. and Suzuki A
    • Organizer
      第38回日本分子生物学会
    • Place of Presentation
      神戸
    • Year and Date
      2015-12-01
    • Data Source
      KAKENHI-PROJECT-15K07052
  • [Presentation] リボソームRNA合成阻害剤はHippo経路エフェクターYAP/TAZ を活性化する2013

    • Author(s)
      日笠弘基
    • Organizer
      日本分子生物学会
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-23570235
  • [Presentation] リボソームRNA合成阻害剤はHippo経路エフェクターYAP/TAZ を活性化する2013

    • Author(s)
      日笠弘基
    • Organizer
      日本分子生物学会
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PUBLICLY-25130709
  • [Presentation] リボソームRNA合成阻害剤はHippo経路エフェクターYAP/TAZを活性化する2013

    • Author(s)
      日笠弘基, 鈴木聡
    • Organizer
      第36回日本分子生物学会年
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-23570235
  • [Presentation] 内在性YAP/TAZ特異的レポーター遺伝子の開発とその応用2012

    • Author(s)
      日笠弘基, 鈴木聡
    • Organizer
      第35回日本分子生物学会年
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-23570235
  • [Presentation] Wnt/HIPK2シグナルによるのTCF3のリン酸化とその機能調節2011

    • Author(s)
      Hikasa H, Suzuki A and Sokol S Y.
    • Organizer
      第7回宮崎サイエンスキャンプ
    • Place of Presentation
      宮崎
    • Data Source
      KAKENHI-PROJECT-23570235
  • [Presentation] The inhibitors for ribosomal RNA synthesis activate the hippo pathway effectors YAP/TAZ

    • Author(s)
      Hikasa Hiroki, Suzuki Akira
    • Organizer
      KEY Forum: From Stem Cells to Organs
    • Place of Presentation
      Kumamoto
    • Year and Date
      2014-09-04 – 2014-09-05
    • Data Source
      KAKENHI-PUBLICLY-25130709
  • [Presentation] リボソームRNAの抑制によるHippo経路エフェクターYAP/TAZ の活性化

    • Author(s)
      日笠弘基、鈴木聡
    • Organizer
      第37回日本分子生物学会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-25 – 2014-11-27
    • Data Source
      KAKENHI-PUBLICLY-25130709
  • 1.  近藤 恭光
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 2.  吉田 稔
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 3.  前濱 朝彦
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 4.  西尾 美希
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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